@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ58: (2017-11-25 )
MFFAVITLFPEMFEAITAYGISGRAAKRDIVQVTCINPRDFAEGSYRRVDERPFGGGPGMVMMAEPLAKAINHAKQLASQAGCVHVPVVYMSPQGKTLNEQAVQQFVDYDGLIVLCGRYEGVDERLIQHYVDQEWSIGDYVLSGGELPAMVLLDSIIRRLPNVMSDEQSAIQDSFVDGLLDCPQYTKPDQFEGLDVPEILKSGHHANIEKWRFLQRYQRTLERRPELIEQVTLTKQQKKWLSDEQG
Atome Classification :
(63 SA)
--.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130---..----......140.......150.......160.......170.....-.--.180.......190.......200.......210.......220....-...230---........240....--------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--M
F
F
A
V
I
T
L
F
P
E
M
F
E
A
I
T
AYGISGRAAK
R
D
I
V
Q
V
T
CI
N
P
R
DFAEGSYRRVDERPFGGGP
G
M
V
M
M
A
E
P
L
A
K
A
I
N
H
A
K
Q
L
A
SQAG
C
V
H
V
P
V
V
Y
MSPQGKTL
N
E
Q
A
V
Q
Q
F
VDYD
G
L
I
V
L
CGRYE
G
V
D
E
R
L
I
Q
H
Y
V----DQ----EWSIG
D
Y
V
LSGGE
L
P
A
M
V
L
L
D
S
I
I
R
R
L
P
N
V
MS
D
E
Q
S
A
I
Q
D
S
F
V
D
-
G
--
L
LDCPQYTKPDQFEGL
D
V
P
E
I
L
KSGHHA
N
I
E
K
W
R
F
L
Q
R
Y
Q
R
T
L
E
R
R
P
E
-
L
I
E
Q
V
----
T
L
T
K
Q
Q
K
K
WLSDEQG--------
53
PsiBlast_CBE
96.08
52%
-170
- C6 -
-
4H3Y
1
TRMD_PARP8
A:
[22-267]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
V
----
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
-
L
I
V
Q
A
R
K
N
K
L
L
S
R
A
D
E
A
W
L
A
------------
51
PsiBlast_CBE
94.33
52%
-166
- C6 -
-
4H3Z
2
TRMD_PARP8
A:
[22-267]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
V
----
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
------
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
-
L
I
V
Q
A
R
K
N
K
L
L
S
R
A
D
E
A
W
L
A
------------
52
PsiBlast_CBE
94.09
52%
-166
- C6 -
-
4H3Y
1
TRMD_PARP8
B:
[22-267]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
V
----
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
-
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
-
L
I
V
Q
A
R
K
N
K
L
L
S
R
A
D
E
A
W
L
A
------------
36
PsiBlast_CBE
93.42
53%
-169
- C6 -
-
4MCC
2
TRMD_HAEIN
B:
[1-242]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
--------
3
PsiBlast_PDB
93.28
53%
-166
- C6 -
-
1UAL
1
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
41
PsiBlast_CBE
92.94
53%
-155
- C6 -
-
4YVK
2
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
---------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
40
PsiBlast_CBE
92.71
53%
-153
- C6 -
-
4YVK
2
TRMD_HAEIN
B:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
30
PsiBlast_CBE
92.62
53%
-167
- C6 -
-
4YQK
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
38
PsiBlast_CBE
92.55
53%
-156
- C6 -
-
4MCB
2
TRMD_HAEIN
B:
[1-242]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
--------
2
PsiBlast_PDB
92.41
53%
-164
- C6 -
-
1UAK
-
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
35
PsiBlast_CBE
92.33
53%
-163
- C6 -
-
4MCD
1
TRMD_HAEIN
A:
[1-242]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
--------
60
HHSearch
92.28
52%
-164
- C6 -
-
4H3Z
2
TRMD_PARP8
A:
[22-269]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
V
----
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
------
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
V
Q
A
R
K
N
K-
L
L
S
R
A
D
E
A
W
L
A
S
L
----------
4
PsiBlast_PDB
92.28
53%
-151
- C6 -
-
1UAM
1
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
--
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
23
PsiBlast_CBE
92.27
53%
-162
- C6 -
-
4YQS
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
43
PsiBlast_CBE
92.21
53%
-154
- C6 -
-
4YVJ
2
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
---------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
58
HHSearch
92.16
55%
-156
- C6 -
-
4MCB
2
TRMD_HAEIN
B:
[1-241]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
1
PsiBlast_PDB
92.07
53%
-167
- C6 -
-
1UAJ
-
TRMD_HAEIN
A:
[1-241]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
20
PsiBlast_PDB
92.04
53%
-166
- C6 -
-
4YQC
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
22
PsiBlast_CBE
92.02
53%
-164
- C6 -
-
4YQT
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
59
HHSearch
92.01
55%
-158
- C6 -
-
4YQD
1
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
----
G
E
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--
A
S
A
---
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
34
PsiBlast_CBE
92.00
53%
-163
- C6 -
-
4YQ8
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
---------
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
18
PsiBlast_PDB
91.95
53%
-162
- C6 -
-
4YQA
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
31
PsiBlast_CBE
91.91
53%
-166
- C6 -
-
4YQJ
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
26
PsiBlast_CBE
91.90
53%
-165
- C6 -
-
4YQP
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
42
PsiBlast_CBE
91.88
53%
-155
- C6 -
-
4YVJ
2
TRMD_HAEIN
B:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
32
PsiBlast_CBE
91.86
53%
-166
- C6 -
-
4YQI
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
25
PsiBlast_CBE
91.86
53%
-166
- C6 -
-
4YQQ
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
9
PsiBlast_PDB
91.78
53%
-168
- C6 -
-
4YQ0
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
48
PsiBlast_CBE
91.77
53%
-157
- C6 -
-
4YQD
1
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--
A
S
A
---
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
45
PsiBlast_CBE
91.74
53%
-162
- C6 -
-
4YVI
2
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
6
PsiBlast_PDB
91.69
53%
-163
- C6 -
-
4YPX
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
50
PsiBlast_CBE
91.58
52%
-165
- C6 -
-
4H3Z
2
TRMD_PARP8
B:
[22-267]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
V
----
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
-
L
I
V
Q
A
R
K
N
K
L
L
S
R
A
D
E
A
W
L
A
------------
49
PsiBlast_CBE
91.51
53%
-168
- C6 -
-
3AXZ
1
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
-----------
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
27
PsiBlast_CBE
91.47
53%
-162
- C6 -
-
4YQO
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
13
PsiBlast_PDB
91.47
53%
-155
- C6 -
-
4YQ4
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
8
PsiBlast_PDB
91.44
53%
-163
- C6 -
-
4YPZ
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
5
PsiBlast_PDB
91.36
53%
-166
- C6 -
-
4YPW
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
7
PsiBlast_PDB
91.35
53%
-159
- C6 -
-
4YPY
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
33
PsiBlast_CBE
91.34
53%
-165
- C6 -
-
4YQG
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
15
PsiBlast_PDB
91.34
53%
-162
- C6 -
-
4YQ6
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
10
PsiBlast_PDB
91.26
53%
-161
- C6 -
-
4YQ1
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
---------
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
44
PsiBlast_CBE
91.12
53%
-153
- C6 -
-
4YVI
2
TRMD_HAEIN
B:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
K
Q
A
S
A
E
E
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
54
PsiBlast_CBE
91.00
51%
-166
- C6 -
-
1P9P
1
TRMD_ECOLI
A:
[7-245]
--
M
W
I
G
I
I
S
L
F
P
E
M
F
R
A
I
T
D
Y
G
V
T
G
R
A
V
K
N
G
L
L
S
I
Q
S
W
S
P
R
D
F
T
H
D
R
H
R
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
A
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
A
G
V
S
E
L
A
T
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
V
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
S
G
G
E
L
P
A
M
T
L
I
D
S
V
S
R
F
I
P
G
V
L
G
-----------
E
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
M
E
V
P
P
V
L
L
S
G
N
H
A
E
I
R
R
W
R
L
K
Q
S
L
G
R
T
W
L
R
R
P
E
-
L
L
E
N
L
----
A
L
T
E
E
Q
A
R
L
L
A
E
-----------
28
PsiBlast_CBE
90.93
53%
-166
- C6 -
-
4YQN
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
24
PsiBlast_CBE
90.80
53%
-160
- C6 -
-
4YQR
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
17
PsiBlast_PDB
90.76
53%
-160
- C6 -
-
4YQ9
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
16
PsiBlast_PDB
90.70
53%
-162
- C6 -
-
4YQ7
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
19
PsiBlast_PDB
90.64
53%
-158
- C6 -
-
4YQB
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
12
PsiBlast_PDB
90.62
53%
-162
- C6 -
-
4YQ3
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
21
PsiBlast_CBE
90.61
53%
-160
- C6 -
-
5D9F
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
-----------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
14
PsiBlast_PDB
90.58
53%
-161
- C6 -
-
4YQ5
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
---------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
29
PsiBlast_CBE
90.16
53%
-161
- C6 -
-
4YQL
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
--------
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
46
PsiBlast_CBE
90.15
53%
-160
- C6 -
-
4YVH
1
TRMD_HAEIN
A:
[21-261]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
--------
D
S
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
11
PsiBlast_PDB
90.12
53%
-158
- C6 -
-
4YQ2
1
TRMD_HAEIN
A:
[9-249]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
------------
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
---------
61
HHSearch
89.65
52%
-162
- C6 -
-
4H3Z
2
TRMD_PARP8
B:
[22-269]
--
M
Q
F
D
I
V
T
L
F
P
D
M
F
R
A
L
T
D
W
G
I
T
S
R
A
A
K
Q
E
R
Y
G
L
R
T
W
N
P
R
D
F
T
T
D
N
Y
R
T
I
D
D
R
P
Y
G
G
G
P
G
M
V
M
L
A
R
P
L
E
D
A
I
N
A
A
K
A
A
Q
A
E
Q
G
I
G
G
A
R
V
V
M
M
S
P
Q
G
A
T
L
N
H
D
K
V
M
R
F
A
A
E
P
G
L
I
L
L
C
G
R
Y
E
A
I
D
Q
R
L
I
D
R
V
V
----
D
E
----
E
V
S
L
G
D
F
V
L
S
G
G
E
L
P
A
M
A
L
I
D
A
V
V
R
H
L
P
G
V
L
N
D
A
Q
S
A
V
Q
D
S
F
V
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
E
Y
D
G
V
R
V
P
D
V
L
L
G
G
H
H
A
E
I
E
Q
W
R
R
R
E
A
L
R
N
T
W
L
K
R
P
D
L
I
V
Q
A
R
K
N
K-
L
L
S
R
A
D
E
A
W
L
A
S
L
----------
39
PsiBlast_CBE
86.67
53%
-172
- C6 -
-
4MCB
2
TRMD_HAEIN
A:
[1-219]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
-
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
------------------------------------
37
PsiBlast_CBE
84.77
53%
-173
- C6 -
-
4MCC
1
TRMD_HAEIN
A:
[1-219]
--
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
G
----
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
G
----------------
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
------------------------------------
81
Fugue
82.78
55%
26
* C6 *
-
1UAL
1
TRMD_HAEIN
A:
[19-270]
SH
M
W
I
G
V
I
S
L
F
P
E
M
F
K
A
I
T
E
F
G
V
T
G
R
A
V
K
H
N
L
L
K
V
E
C
W
N
P
R
D
F
T
F
D
K
H
K
T
V
D
D
R
P
Y
G
G
G
P
G
M
L
M
M
V
Q
P
L
R
D
A
I
H
T
A
K
A
A
A
G
E
----
G
A
K
V
I
Y
L
S
P
Q
G
R
K
L
D
Q
G
G
V
T
E
L
A
Q
N
Q
K
L
I
L
V
C
G
R
Y
E
G
I
D
E
R
L
I
Q
T
E
I
----
D
E
----
E
W
S
I
G
D
Y
V
L
T
G
G
E
L
P
A
M
T
L
I
D
A
V
A
R
F
I
P
G
V
L
S
---------
F
A
D
-
G
--
L
L
D
C
P
H
Y
T
R
P
E
V
L
E
G
L
T
V
P
P
V
L
M
S
G
H
H
E
E
I
R
K
W
R
L
K
Q
S
L
Q
R
T
W
L
R
R
P
E
-
L
L
E
G
L
----
A
L
T
D
E
Q
R
K
L
L
K
E
A
Q
A
E
H
N
S
L
EHH
65
HHSearch
80.29
40%
-173
- C6 -
-
4IG6
1
TRMD_ANAPZ
A:
[22-243]
--
M
I
F
N
V
L
T
I
F
P
Q
M
F
P
G
P
L
G
V
S
N
L
G
S
A
L
K
K
G
L
W
T
L
N
V
F
D
I
R
A
F
A
N
N
K
H
N
T
V
D
D
T
P
Y
G
G
G
P
G
M
L
L
R
A
D
V
L
G
R
C
I
D
E
V
L
S
L
-----
H
P
N
T
K
L
M
F
T
S
P
R
G
V
S
F
T
Q
D
I
A
R
Q
T
M
N
F
D
N
I
T
L
L
C
G
R
F
E
G
I
D
E
R
V
V
D
F
Y
K
----
L
Q
----
E
V
S
I
G
D
Y
V
L
S
G
G
E
L
A
A
M
V
I
I
D
T
C
V
R
M
V
P
G
V
I
G
N
A
E
S
L
K
Q
E
S
M
E
--
G
--
S
L
E
Y
P
Q
Y
T
R
P
A
S
W
K
G
M
E
V
P
E
V
L
L
T
G
N
H
G
E
I
E
K
W
R
R
N
A
S
L
S
I
T
A
A
R
R
P
D
-
L
L
------------------------------
55
PsiBlast_CBE
80.26
39%
-169
- C6 -
-
4IG6
1
TRMD_ANAPZ
A:
[22-243]
--
M
I
F
N
V
L
T
I
F
P
Q
M
F
P
G
P
L
G
V
S
N
L
G
S
A
L
K
K
G
L
W
T
L
N
V
F
D
I
R
A
F
A
N
N
K
H
N
T
V
D
D
T
P
Y
G
G
G
P
G
M
L
L
R
A
D
V
L
G
R
C
I
D
E
V
L
S
L
H
P
-----
N
T
K
L
M
F
T
S
P
R
G
V
S
F
T
Q
D
I
A
R
Q
T
M
N
F
D
N
I
T
L
L
C
G
R
F
E
G
I
D
E
R
V
V
D
F
Y
K
----
L
Q
----
E
V
S
I
G
D
Y
V
L
S
G
G
E
L
A
A
M
V
I
I
D
T
C
V
R
M
V
P
G
V
I
G
N
A
E
S
L
K
Q
E
S
-
M
E
-
G
--
S
L
E
Y
P
Q
Y
T
R
P
A
S
W
K
G
M
E
V
P
E
V
L
L
T
G
N
H
G
E
I
E
K
W
R
R
N
A
S
L
S
I
T
A
A
R
R
P
D
-
L
L
------------------------------
57
PsiBlast_CBE
78.98
36%
-162
- C6 -
-
3QUV
3
?
A:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
P
V
R
-
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
---
E
I
C
T
S
E
T
L
L
V
V
P
----
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
A
----
T
R
M
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
-------------AS
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
-
L
L
------------------------------
56
PsiBlast_CBE
75.95
36%
-145
- C6 -
-
3QUV
2
?
B:
[5-231]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
P
V
R
-
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
---
E
I
C
T
S
E
T
L
L
V
V
P
----
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
A
----
T
R
M
R
V
R
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
A
L
S
A
---------AS
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
-
L
L
------------------------------
67
HHSearch
74.89
38%
-144
- C6 -
-
3QUV
2
?
B:
[5-233]
--
M
K
I
D
V
V
T
I
F
P
E
Y
L
Q
-
P
V
R
Q
S
L
P
G
K
A
I
D
A
G
L
V
D
V
A
V
H
D
L
R
R
W
T
H
D
V
H
K
S
V
D
D
S
P
Y
G
G
G
P
G
M
V
M
K
P
T
V
W
G
D
A
L
D
E
I
C
T
-------
S
E
T
L
L
V
V
P
T
P
A
G
Y
P
F
T
Q
E
T
A
W
Q
W
S
T
E
D
H
L
V
I
A
C
G
R
Y
E
G
I
D
Q
R
V
A
D
D
A
A
T
R
M
R
V
R
----
E
V
S
I
G
D
Y
V
L
N
G
G
E
A
A
A
L
V
I
I
E
A
V
L
R
L
V
P
G
V
L
G
N
A
L
S
A
-------A
S
--
L
L
E
G
P
S
Y
T
R
P
P
S
W
R
G
M
D
V
P
P
V
L
L
S
G
D
H
A
K
I
A
A
W
R
A
E
Q
S
R
Q
R
T
I
E
R
R
P
D
-
L
L
G
F
----------------------------