@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ82: (2017-11-25 )
MDKQIIFEDEHIRAIFLQGDSNTLVLSFGDLITRASGLSINAEKSLIKYQYNVIGVMPKQKSWFPKASMVELAKVILPIIQRFKNIVGYGGSMGGYAAIKYSNLLNMNRIIAFVPQYSIDPEQVEDRRYAEFFDAVANNDMQIQPQDVDASREYIIVYDPYFSIDREHYLKIKEILPSLHTIHLPFTGHEALSVLASSSLLHDFIEHEFDETYFYQQVRKIKKQSKFYYRNVLANVLTYHDSMLLKILRQNDFQLDERYLDNPLKQAVTRSLIKTKQATEQDFQKLGIKIQYSQQAKNPKKGFKNQFDAILVFNLINLKLETYAVDVVLANPSYLIPIVAGHTGVVQIELNNELYLLGMNDRKIIKLFKQGDALTSDMSPFVIKQYSDFFALSYKQLNLNCDKQGVCDYVESSIQPSQQFVLTSY
Atome Classification :
(20 SA)
-----------------------------------------------------------........--.10------------.......-.-----.-----20-.------......--------..30-------------.......--------..40-.........--50.------...-..----..60-.---------.---.----------------------------.-.--------.------.-------------.----.70.......---.80----.-----.-----......--------------------.90.------......-.-----100...-------------.---...110.-..--------------....120...----.-------------------------------.-----.------------.130----------------.--.-.-----------------..---.----------..140---..--.-----.-...-----.---150....-....160..-....--.170....--.----.----.180..--.....190.-......-200..---...----.---------.210.....---------..220....---...230-..-----.....240--..--.....250......----.260....------...270...---....280....-...290...--.....300.....-..310......--.320.......330.......-----340..--------.....350........360...--....370...-...-.380.......390....------...400....-...410----.......420--....----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------MDK
Q
I
I
F
E--DE-------------
H
I
R
A
I
F
L
-Q-----G-----D--S------
N
T
L
V
L
S
--------
F
G
D
--------------
L
I
TRASG--------
L
S
I--NAEK
S
L
I
K
Y
--
Q
Y
N
------
V
I
G
-VM----PKQ--K---------S---W----------------------------F-P--------
K
------
A
-------------
S
----
M
V
E
L
A
K
V
I
L
P
---
I
I
-----
Q
-----
R
-----
F
K
N
I
VG--------------------YGGS------MGG
Y
A
A
-
I
-----
K
Y
S
N
LL-------------N---
M
N
R
I
I
A
F-VP--------------QYSI
D
P
E
Q
V
E
----
D
-------------------------------
R
-----
R
------------
Y
A
E
-----------------
F
--
F
-
D
-----------------
A
V---A----------NND
M
----
Q
I
--Q-----P-QDV-----D---A-SR
E
Y
I
-
I
V
YDPYFSI-
D
R
E
H
--
Y
L
K
I
K
E
IL--P----S----L
H
T
I
H
L--PFT
G
H
E
A
L
S
-
V
L
A
S
S
S
-
L
L
H
D
F
---
I
E
H
----E---------F
D
E
T
Y
F
Y
Q
Q
---------
V
R
K
I
K
K
Q
S
K
---
F
Y
Y
R
N
V
-
L
A
-----
N
V
L
T
Y
H
D
S
--
M
L
--
L
K
I
L
R
QNDF
Q
L
D
E
R
----
Y
LD
N
P
L
K
Q
------
A
V
T
R
S
L
I
KT---K
Q
A
T
E
Q
D
F
Q
KL-
G
I
K
I
-
Q
YSQ--QAKNPKKGFKNQF-D
A
I
L
V
F
N
L
IN
L
--
K
L
E
T
Y
A
V
D
V
V
LANP
S
Y
L
I
P
I
V-----AGH
T
G
--------
V
V
Q
I
E
LN-N
E
L
Y
L
L
GMN
D
R
K
I
I
--
K
L
F
KQGDALT-SDM-
S
P
F
V
I
K
Q
Y
S
D
F
F
A
L
S
Y
K
Q
------LNLNCDKQ
G
V
-
C
D
Y
V
E
S
----SIQPS
Q
Q
F
V
---LTSY----------------------------
50
Fugue
57.00
17%
-9
- C2 -
-
5LGR
5
CARM1_MOUSE
B:
[9-351]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
--------
F
S
E
--
R
T
E
E
S
S
A
V
Q
--
Y
F
Q
------
F
Y
G
-
Y
L
----
S
Q
Q
--
Q
---------
N
---
M
----------------------------
M
-
Q
D-------
Y
------
V
-------------
R
----
T
G
T
Y
Q
R
A
I
L
Q
---
N
H
-----
T
-----
D
-----
F
K
D
K
I
V
--------------------
L
D
V
G
------
C
G
S
G
I
L
-
S
-----
F
F
A
A
Q
A
-------------
G
---
A
R
K
I
Y
A
V
E
A
S
--------------
T
M
A
Q
H
A
E
V
L
V
----
K
-------------------------------
S
NNLTD
R
------------
I
V
V
-----------------
I
--
P
-
G
-----------------
K
V
---
E
----------
E
V
S
L
--------------
P
-
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Q
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-----
D
---
I
-
I
I
S
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P
-
M
G
Y
M
L
F
N
E
R
-
M
L
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--
Y
L
H
A
K
K
Y
L
--
K
----
P
----
S
G
N
M
F
---
P
T
I
G
D
V
H
L
A
-
P
F
T
------------------------------
D
E
Q
L
Y
M
E
Q
---------
F
T
K
A
N
F
W
Y
Q
---
P
S
F
H
G
V
D
L
S
-----
A
L
R
G
A
A
V
D
--
E
Y
--
F
R
Q
P
V
V
D
T
F
D
I
R
I
L
----
M
A
K
S
------------
V
K
Y
T
V
N
F
---
L
E
A
K
E
G
D
L
H
R
I
-
E
I
P
F
-
K
F
H
M
--
L
H
S
G
L
V
H
G
L
A
F
W
F
-
D
V
A
F
I
G
S
I
M
T
V
--
W
L
S
T
A
P
T
E
P
L
-----------------
T
H
W
Y
--------
Q
V
R
C
L
F
Q
-
S
P
L
F
A
--------------
K
A
G
D
T
L
S
-
G
T
C
-
L
L
I
A
N
K
R
Q
S
Y
D
I
S
I
V
A
Q
V
-----------
D
Q
T
G
S
-----
K
S
----
S
N
L
L
D
L
K
N
P
---
F
F
R
Y
----------------------------
44
Fugue
54.86
17%
13
- C4 -
-
5H9X
-
?
A:
[24-444]
------------------------------------------------A
D
F
T
Q
G
A
D
V
S
G
N
N
V
T
L
W
F
K
--
S
S
VNTT
W
V
-------
D
V
H
Y
K
V
N
-
S
-----
G
-----
V
--
Q
------
Q
N
V
R
M
S
--------
F
N
A
--------------
G
A
A
R
F
E
H
--------
T
I
L
--
T
A
A
Q
A
E
I
E
Y
--
F
F
T
------
Y
N
N
-
G
V
----
P
A
Y
--
D
---------
T
T
T
F
T
----------------------------
Y
-
R
--------
T
------
N
-------------
S
----
I
Y
S
I
P
A
S
S
I
P
---
Q
P
-----
S
-----
E
G
G
V
S
-
L
K
V
M
N
G
--------------------
T
G
G
A
YTDDQ
I
Y
W
G
V
I
G
-
I
N
PVNG
K
W
S
Y
L
D
-------------
L
---
A
G
R
L
L
P
I
-
S
S
--------------
D
L
N
N
A
P
G
H
L
T
K
D--
G
-------------------------------
I
-----
N
------------
Y
A
N
-----------------
I
--
Y
-
H
-----------------
K
I
---
S
----------
D
A
N
W
----
V
N
--
L
-----
P
-
K
-
I
-----
E
---
S
-
G
R
L
F
L
-
S
V
G
S
P
L
Y
-----------------------------
M
K
T
F
D
D
--
G
F
A
G
P
D
L
N
N
P
T
D
P
N
L
N
-
I
I
F
D
F
---
V
E
F
----
T
---------
V
D
K
D
G
Y
H
G
N
---------
T
T
R
V
D
-
Q
F
G
---
F
P
I
Q
H
R
-
L
V
-----
N
L
A
G
N
Y
D
R
--
T
V
--
G
E
L
E
S
E
T
R
S
G
L
F
A
K
----
Y
V
N
E
-------------------------
V
P
Y
E
F
K
S
L
-
G
T
L
Q
-
A
P
Y
R
--
I
L
S
P
M
K
G
P
F
Q
E
G
G
-
A
Y
E
N
Y
F
A
G
Y
S
-----
S
I
S
T
Q
D
I
L
L
G
V
G
------------
E
A
S
N
P
--------
E
V
C
A
A
L
N
-
R
H
V
Y
T
E
P
D
N
W
N
R
V
D
--
Q
Y
Y
Q
A
A
P
A
---
N
Y
Y
-
A
K
F
W
H
D
H
S
I
D
G
L
A
Y
G
F
C
Y
------
D
D
V
N
----
G
Q
-
A
A
Y
L
E
V
----
G
-
D
P
K
G
L
I
V
---
R
V
G
W
----------------------------
23
HHSearch
53.18
14%
-40
- C8 -
-
3DKR
-
?
A:
[19-231]
--------------------------------------------------------------------------------------------------
E
-----
G
--
T
------
D
T
G
V
V
L
--------
L
H
A
--------------
Y
T
G
S
P
N
D
--------
M
N
F
---
M
A
R
A
L
Q
R
S
--
G
Y
G
------
V
Y
V
-
P
L
----
F
S
G
--
H
GT-------
V
---
E
----------------------------
P
-
L
D
I
L
T
----
K
------
G
-------------
N
P
D
I
W
W
A
E
S
S
A
A
V
A
H
---
M
T
-----
A
-----
K
-----
Y
A
K
V
F
V
--------------------
F
G
L
S
------
L
G
G
I
F
A
-
M
-----
K
A
L
E
T
L
-------------
P
GI-
T
A
G
G
V
F
S
-
S
P
--------------
I
L
P
G
K
H
H
L
V
P
G
---
F
-------------------------------
L
-----
K
------------
Y
A
E
-----------------
Y
--
M
-
N
R
L
A
GKSDE
S
T
Q
I
L
A
Y
L
P
G
Q
---
L
A
A
--------
I
D
Q
F
----
A
T
--
T
-----
V
A
A
D
L
N----
L
---
V
-
K
Q
P
T
F
-
I
G
Q
A
G
Q
D
E
L
V
D
G
R
L
--
A
Y
Q
L
R
D
A
L
--
I
NAA-
R
----
V
D
F
H
W
Y
--
D
D
A
K
H
V
I
T
V
-
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
52.59
16%
-53
- C8 -
-
4H0C
3
?
A:
[21-196]
-----------------------------------------------------------------------------------------------------------
A
------
K
K
A
V
V
M
--------
L
H
G
--------------
R
G
G
T
A
A
D
--------
I
-
I
--
S
L
Q
K
V
L
K
L
D
--
E
M
A
------
I
Y
A
-
P
Q
----
A
T
N
--
N
---------
S
---
W
----------------------------
Y
-
P
--------
Y
------
S
FMAPVQQNQ
P
A
L
D
S
----
A
L
A
L
V
G
E
V
V
A
---
E
I
-----
E
A
Q
GI-
P
-----
A
E
Q
I
Y
F
--------------------
A
G
F
S
------
Q
G
A
C
L
T
-
L
-----
E
Y
T
T
R
N
-------------
A
RK-
Y
G
G
I
I
A
F
-
T
G
--------------
G
L
I
G
Q
E
L
A
I
G
--------------------------------------------------------------------------------------------------------------------
N
Y
----------------
K
G
D
-----
F
---
K
-
Q
T
P
V
F
-
I
S
T
G
N
P
D
P
H
V
P
V
S
R
--
V
Q
E
S
V
T
I
L
--
E
----
D
M
NAA
V
S
Q
V
V
Y
--
P
G
R
P
H
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
50.78
16%
-51
- C8 -
-
4H0C
2
?
B:
[21-196]
-----------------------------------------------------------------------------------------------------------
A
------
K
K
A
V
V
M
--------
L
H
G
--------------
R
G
G
T
A
A
D
--------
I
-
I
--
S
L
Q
K
V
L
K
L
D
--
E
M
A
------
I
Y
A
-
P
Q
----
A
T
N
--
N
---------
S
---
W
----------------------------
Y
-
P
--------
Y
------
S
FMAPVQQNQ
P
A
L
D
S
----
A
L
A
L
V
G
E
V
V
A
---
E
I
-----
E
A
Q
GI-
P
-----
A
E
Q
I
Y
F
--------------------
A
G
F
S
------
Q
G
A
C
L
T
-
L
-----
E
Y
T
T
R
N
-------------
A
RK-
Y
G
G
I
I
A
F
-
T
G
--------------
G
L
I
G
Q
E
L
A
I
G
--------------------------------------------------------------------------------------------------------------------
N
Y
----------------
K
G
D
-----
F
---
K
-
Q
T
P
V
F
-
I
S
T
G
N
P
D
P
H
V
P
V
S
R
--
V
Q
E
S
V
T
I
L
--
E
----
D
M
NAA
V
S
Q
V
V
Y
--
P
G
R
P
H
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
50.20
18%
30
- C6 -
-
5F86
1
RUMI_DROME
A:
[30-394]
-------------------------------------------------------N
E
D
E
F
S
F
K
I
R
R
Q
--
I
E
-------------
K
A
N
A
D
Y
K
-
P
CSSDP
Q
-----
D
--
S
DCSCH
A
N
V
L
K
R
D
--------
L
A
P
--------------
Y
--
K
S
T
G
--------
V
T
R
--
Q
M
I
E
S
S
A
R
Y
G
T
K
Y
K
------
I
Y
G
H
R
L
----
Y
R
D
--
A
---------
N
---
C
----------------------------
M
-
F
--------
P
------
A
-------------
R
----
C
E
G
I
E
H
F
L
L
P
---
L
V
-----
A
-----
T
----------------------------------------------------------
L
P
-------------
D
---
M
D
L
I
I
N
T
---------------------------------------------------------------
R
-----
D
------------
Y
P
Q
-----------------
L
--
N
-
A
-----------------
A
W
---
G
----------
N
A
---------------------------------------
A
G
G
P
V
F
S
F
-
S
K
T
K
----
E
Y
R
D
I
M
--
Y
----
P
----
A
W
T
F
W
A
GG
P
A
T
K
L
H
P
R
G
-
I
-
G
R
W
D
-
Q
M
R
E
K
---
L
E
K
----
R
---------
A
A
A
I
P
W
S
Q
---------------
K
R
S
L
---
G
F
F
R
G
S
-
R
T
-----
S
---
D
E
R
D
--
S
L
--
I
L
L
S
R
R
N
P
E
L
V
E
A
Q
----
Y
T
K
N
Q
-
G
W
------
K
S
P
K
D
T
L
D
A
---
P
A
A
D
E
V
S
F
E
D
H
C
K
Y
K
Y
-
L
F
N
F
--
R
G
V
A
A
S
F
R
L
K
H
L
F
L
C
K
S
L
V
F
H
V
G
D
E
--
W
Q
E
F
F
Y
D
Q
L
-------------------
K
P
W
--------
V
H
Y
V
P
L
K
-
S
--
Y
P
S
Q
Q
E
Y
E
H
I
L
--
S
F
F
K
K
N
D
A
L
A
-
Q
E
I
-
A
----
Q
R
G
Y
D
F
I
W
E
H
L
R
M
------
K
D
I
K
C
Y
W
R
K
L
-
L
K
R
Y
V
K
L
LQ
Y
E
V
K
P
E
D
Q
L
I
---
Y
I
G
P
----------------------------
32
HHSearch
48.89
15%
-14
- C8 -
-
3FSG
1
?
C:
[48-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Q
Y
Q
------
R
I
Y
-
L
D
----
L
P
G
MG
N
---------
S
---
D
----------------------------
P
I
S
--------
P
------
S
-------------
T
----
S
D
N
V
L
E
T
L
I
E
---
A
I
-----
E
EII--
G
-----
A
R
R
F
I
L
--------------------
Y
G
H
S
------
Y
G
G
Y
L
A
-
Q
-----
A
I
A
F
H
L
-------------
K
DQ-
T
L
G
V
F
L
T
-
C
P
--------------
V
I
T
A
D
H
S
K
R
L
T---
G
KHINILEEDINPVEN----------------
K
EYFA-
D
FLSMNVIINNQA
W
H
D
-----------------
Y
--
Q
-
N
LIIPGLQKED-------
K
T
---
F
----------
I
D
Q
L
QNNY
S
F
--
T
-----
F
E
E
K
L
-----
K
NIN
Y
-
Q
F
P
F
K
-
I
M
V
G
R
N
D
Q
V
V
G
Y
Q
E
--
Q
L
K
L
I
N
H
N
--
E
----
N
----
G
E
I
V
L
L
--
N
R
T
G
H
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
48.13
15%
-11
- C8 -
-
3FSG
4
?
A:
[48-249]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Q
Y
Q
------
R
I
Y
-
L
D
----
L
P
G
MG
N
---------
S
---
D
----------------------------
P
I
S
--------
P
------
S
-------------
T
----
S
D
N
V
L
E
T
L
I
E
---
A
I
-----
E
E
I
I--
G
-----
A
R
R
F
I
L
--------------------
Y
G
H
S
------
Y
G
G
Y
L
A
-
Q
-----
A
I
A
F
H
L
-------------
K
DQ-
T
L
G
V
F
L
T
-
C
P
--------------
V
I
T
A
D
H
S
K
R
L
T
---
G
K
H
I
N
ILE
E
D
I
N
P
V
E
N----------------
K
EY
F
A
-
D
F
L
S
M
NVIIN
N
Q
A
W
H
D
-----------------
Y
--
Q
-
N
LI
I
P
G
L
Q
K
ED-------
K
T
---
F
----------
I
D
Q
L
Q
N
N
Y
S
F
--
T
-----
F
E
E
K
L
-----
K
N
IN
Y
-
Q
F
P
F
K
-
I
M
V
G
R
N
D
Q
V
V
G
Y
Q
E
--
Q
L
K
L
I
N
H
N
--
E
----
N
----
G
E
I
V
L
L
--
N
R
T
G
H
N
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
47.72
11%
-14
- C8 -
-
2JBW
-
DHPON_PAENI
D:
[132-347]
---------------------------------------------------------------
L
V
V
D
--
G
I
-------------
P
M
P
V
Y
V
R
I
P
-----
E
-----
G
PG
P
------
H
P
A
V
I
M
--------
L
G
G
--------------
L
E
S
T
K
E
E
--------
S
F
---
Q
M
E
N
L
V
L
D
R
--
G
M
A
------
T
A
T
-
F
D
----
G
P
G
--
Q
GE-------
M
---
F
----------------------------
E
-
Y
KRI-----
A
------
G
-------------
D
----
Y
E
K
Y
T
S
A
V
V
D
---
L
L
-----
T
-----
K
LEAIR
N
D
A
I
G
V
--------------------
L
G
R
S
------
L
G
G
N
Y
A
-
L
-----
K
S
A
A
C
E
P------------
R
---
L
A
A
C
I
S
W
-
G
G
--------------
F
S
D
L
D
Y
W
D
L
E
TPLT
K
-------------------------------
E
-----
S
------------
W
K
Y
-----------------
V
SK
V
-
D
TLEEAR-----------
L
H
---
V
----------
H
A
A
L
----
E
T
--
R
-----
D
-
V
L
S
-----
Q
---
I
-
A
C
P
T
Y
-
I
L
H
G
V
H
D
E
V
-
P
L
S
F
--
V
D
T
V
L
E
L
V
--
P
AE--
H
----
L
N
L
V
V
E
--
K
D
G
D
H
C
C
H
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
47.36
13%
-12
* C4 *
-
1DHP
-
DAPA_ECOLI
A:
[1-292]
-----------------------------------------------------------
M
F
T
G
S
I
V
A
-------------------------------------------------
I
V
T
P
--------
M
------------------
D
E
K
G
N
--------
V
C
R
--
A
S
L
K
K
L
I
D
Y
--
H
V
A
S
GTSAI
V
S
V
-
G
T
----
T
G
E
--
S
---------
A
---
T
----------------------------
L
-
N
--------
H
------
D
-------------
E
----
H
A
D
V
V
M
M
T
L
D
---
L
A
-----
D
-----
G
-----
R
I
P
V
I
A
--------------------
G
T
G
A
------
N
A
T
A
E
A
-
I
-----
S
L
T
Q
R
F
-------------
N
DSG
I
V
G
C
L
T
V
-
T
P
--------------
Y
Y
N
R
P
S
Q
E
G
L
----
Y
-------------------------------
Q
-----
H
------------
F
K
A
-----------------
I
--
A
-
E
-----------------
H
T
---
D
-----------
L
P
-----------------------------------
Q
-
I
L
Y
N
V
---------------------
P
----
S
----
R
T
G
C
D
L
--
L
---
P
E
T
V
G
-
R
L
A
K
V
K
-
N
I
I
G
I
---
K
E
A
----
T
---------
G
N
----
L
T
R
---------
V
N
Q
I
K
E
L
V
S
---
D
D
F
-----------
V
L
L
S
G
D
D
A
--
S
A
--
L
D
F
M
Q
L
G
---------------------------
G
H
G
V
I
S
V
------
T
A
N
V
A
A
R
D
-
M
A
Q
M
-
C
K
L
A
--
A
E
G
H
F
A
E
A
R
V
I
N
Q
-
R
L
M
P
L
H
N
K
L
F
V
--
E
P
N
P
I
P
V
K
W
A
C
K
E
---------------------------------------
L
G
L
V
A
T
D
T
L
--
R
L
P
M
T
P
I
T
------------
D
S
G
R
E
T
V
R
A
A
L
K
H
------
A
G
L
L
-------------------------------------------------------------
33
HHSearch
47.14
15%
-5
* C8 *
-
3BDI
2
?
A:
[25-189]
--------------------------------------------------------------------------------------------------------
S
--
N
------
R
R
S
I
A
L
--------
F
H
G
--------------
Y
S
F
T
S
M
D
--------
W
D
K
A-
D
L
F
N
N
Y
S
K
I
--
G
Y
N
------
V
Y
A
-
P
D
----
Y
P
G
--
F
---------
G
---
R
----------------------------
S
-
A
SSEKYGID
R
------
G
-------------
D
----
L
K
H
A
A
E
F
I
R
D
---
Y
L
-----
K
A
N
---
G
-----
V
A
R
S
V
I
--------------------
M
G
A
S
------
M
G
G
G
M
V
-
I
-----
M
T
T
L
Q
Y
-------------
P
DI-
V
D
G
I
I
A
V
-
A
P
--------------
A
W
V
E
S
L
K
------------------------------------------------------------
G
-----------------------------------------
D
-----------------------------------
M
K
-----
K
---
I
-
R
Q
K
T
L
-
L
V
W
G
S
K
D
H
V
V
P
I
A
L
--
S
K
E
Y
A
S
I
I
--
S
----
G
----
S
R
L
E
I
V
--
E
G
S
G
H
P
V
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
46.90
11%
8
- C8 -
-
1THT
-
LUXD_VIBHA
A:
[17-303]
---------------------------------------------------------------------
G
Q
-------------
E
L
H
V
W
E
T
-
P
-----
P
K
ENVP
F
--
K
------
N
N
T
I
L
I
--------
A
S
G
--------------
F
A
R
R
M
D
H
--------
F
A
---
G
L
A
E
Y
L
S
T
N
--
G
F
H
------
V
F
R
-
Y
D
----
S
L
H
--
H
V-------------------------------------------
E
---------------
F
-------------
T
----
M
T
T
G
K
N
S
L
C
T
V
Y
H
W
L
-----
Q
T
K
---
G
-----
T
Q
N
I
G
L
--------------------
I
A
A
S
------
L
S
A
R
V
A
-
Y
-----
E
V
I
S
D
L
-------------
E
---
L
S
F
L
I
T
A
-
V
G
--------------
V
V
N
L
R
D
T
L
E
K
A
L
--
G
-------------------------------
F
-----
D
------------
Y
L
S
LPIDELPNDLDFEGHKL
G
--
S
-
E
-----------------
V
F
---
V
----------
R
D
C
F
----
E
H
HW
D
T
L
D
S
T
L
-
D
K
V
-----
A
---
N
T
S
V
P
L
I
-
A
F
T
A
N
N
D
D
W
V
K
Q
E
E
--
V
Y
D
M
L
A
H
I
RT
G
----
H
----
C
K
L
Y
S
L
--
L
G
S
S
H
D
L
G
E
-
N
L
V
V
L
R
N
F
Y
Q
S
V
T
K
A
A
I
A
M
D
G
G
S
LEID
V
D
F
I
E
P
D
F
E
Q
L
T
I
A
---------
T
V
N
E
R
R
L
K
A
---
E
I
E
N
R
T
-
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
46.73
15%
-38
- C8 -
-
5AO9
12
?
A:
[68-251]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Y
F
A
G
R
--
G
M
V
------
A
M
A
-
A
D
----
Y
R
V
--
G
---------
S
---
R
----------------------------
H
-
N
--------
V
K
V
A
D
C
V
A
-------------
D
----
A
K
S
A
I
R
W
V
R
Q
---
H
A
-----
A
ELGV-
D
-----
P
Q
K
I
V
A
--------------------
S
G
G
S
------
A
G
G
H
L
A
-
A
-----
C
T
V
M
V
P
DLEAPEEDHTISS
Q
---
A
N
A
A
I
L
F
-
N
P
--------------
V
L
I
L
S
R
E
G
L
K
P---
R
-------------------------------
Q
-----
D
------------
W
E
E
-----------------
R
--
L
-
R
-----------------
E
R
---
L
----------
G
T
E
P
K---
A
V
--
S
-----
P
Y
H
H
I
R----
A
---
G
-
L
P
P
M
I
-
I
F
H
G
T
A
D
N
T
V
P
F
E
T
--
I
R
L
F
A
E
A
M
--
K
K
A
GN
R
----
C
E
L
V
P
F
--
E
G
A
A
H
G
F
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
46.30
11%
-12
- C8 -
-
2JBW
-
DHPON_PAENI
B:
[132-347]
---------------------------------------------------------------
L
V
V
D
--
G
I
-------------
P
M
P
V
Y
V
R
I
P
-----
E
-----
G
P
G
P
------
H
P
A
V
I
M
--------
L
G
G
--------------
L
E
S
T
K
E
E
--------
S
F
---
Q
M
E
N
L
V
L
D
R
--
G
M
A
------
T
A
T
-
F
D
----
G
P
G
--
Q
GE-------
M
---
F
----------------------------
E
-
Y
KRI-----
A
------
G
-------------
D
----
Y
E
K
Y
T
S
A
V
V
D
---
L
L
-----
T
-----
K
LEAIR
N
D
A
I
G
V
--------------------
L
G
R
S
------
L
G
G
N
Y
A
-
L
-----
K
S
A
A
C
E
P------------
R
---
L
A
A
C
I
S
W
-
G
G
--------------
F
S
D
L
D
Y
W
D
L
E
T
P
L
T
K
-------------------------------
E
-----
S
------------
W
K
Y
-----------------
V
S
K
V
-
D
T
L
E
E
A
R
-----------
L
H
---
V
----------
H
A
A
L
----
E
T
--
R
-----
D
-
V
L
S
-----
Q
---
I
-
A
C
P
T
Y
-
I
L
H
G
V
H
D
E
V
-
P
L
S
F
--
V
D
T
V
L
E
L
V
--
P
AE--
H
----
L
N
L
V
V
E
--
K
D
G
D
H
C
C
H
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
46.21
11%
-9
- C8 -
-
3H04
-
?
A:
[12-251]
------------------------------------------------------------------
D
--
A
F
-------------
A
L
P
Y
T
I
I
-
K
-----
A
K----
N
QP
T
------
K
G
V
I
V
Y
--------
I
H
G
--------------
G
G
L
M
F
G
K
--------
A
N
D
LS
P
Q
Y
I
D
I
L
T
E
--
H
Y
D
------
L
I
Q
-
L
S
----
Y
R
L
--
L
---------
P
---
E
----------------------------
V
-
S
--------
L
------
D
-------------
C
I
---
I
E
D
V
Y
A
S
F
D
A
---
I
Q
-----
S
Q
Y
---
S
-----
N
C
P
I
F
T
--------------------
F
G
R
S
------
S
G
A
Y
L
S
-
L
-----
L
I
A
R
D
R
-------------
D
---
I
D
G
V
I
D
F
-
Y
G
--------------
Y
S
R
I
N
T
E
P
F
K
T
---
T
NSYY
A
K
I
A
Q
S
I
N
E
T
M
I
A
Q
L
TSPTPVVQDQIA
Q
-----
R
------------
F
L
I
Y
----------------
V
--
Y
-
A
-----------------
R
G
T
GK
W
I
N
M
I
NIADYT
D
S
K
Y
----
N
I
--
A
-----
P
-
D
E
L
-----
K
---
T
-
L
P
P
V
F
-
I
A
H
C
N
G
D
Y
D
V
P
V
E
E
--
S
E
H
I
M
N
H
V
--
P
----
H
----
S
T
F
E
R
V
--
N
K
N
E
H
D
F
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
45.37
10%
-97
* C6 *
-
2JK8
1
BEPA_BARHE
A:
[12-302]
---------------------------------------------------------------------
E
I
-------------
I
S
P
H
H
Y
V
-
Y
-----
P
-----
N
--
T
------
T
T
L
K
N
K
--------
Y
G
-----------------
I
K
N
L
N
--------
A
F
L
--
E
K
C
S
H
D
T
A
K
--
A
M
I
------
N
L
R
-
E
E
----
S
L
P
--
E
---------
Y
--------------------------------
F
-
D
--------
T
------
A
-------------
Y
----
L
C
H
I
H
Q
Q
L
F
K
---
N
T
-----
F
-----
E
-----
W
--------------------------------------
A
G
Y
-
L
-----
R
H
I
P
F
T
-------------
F
---
A
D
G
T
T
A
A
-
M
P
--------------
E
M
K
R
T
G
W
K
N
A
----
F
-------------------------------
A
-----
I
------------
G
D
E
-----------------
I
--
Q
-
E
-----------------
G
L
---
Q
----------
R
L
D
Q
----
T
L
--
A
-----
E
-
K
N
N
-----
L
---
Q
-
G
L
T
-------------
R
E
E
F
--
N
S
E
A
I
E
L
F
--
N
----
S
----
L
N
Q
L
H
P
--
F
R
E
G
N
G
R
T
Q
-
R
L
F
F
E
N
-
L
A
K
A
A
------------------------------------------------------
G
H
-
Q
L
-----
N
F
S
L
I
T
K
E
--
R
M
--
M
V
A
S
V
A
V
A
E
N
G
D
L
E
----
P
M
Q
H
L
F
E
D
------
I
S
N
P
E
K
I
R
L
---
L
K
E
F
M
H
T
M
K
N
T
-
G
----------------------------------
R
--
N
V
N
D
R
P
V
M
V
A
K
E
G
E
T
Y
T
G
T
Y
R
-----
G
A
G
L
E
--------
G
F
A
L
N
V
K
-
G
-------------------------------
A
Y
I
I
G
N
I
D
H
L
P
P
E
Q
L
K
I
------
L
K
----------------------
P
G
D
K
I
T
---
F
T
A
P
K---------------------------
47
Fugue
45.01
16%
-3
- C3 -
-
5SVD
-
NOP9_YEAST
A:
[5-589]
QMFF
G
V
L
D
R
E
E
L
E
Y
F
K
Q
A
E
S
T
L
Q
L
DAFEA
P
E
E
K
F
Q
F
V
T
S
I
I
E
E
A
KGK
E
L
K
L
V
T
SQIT
S
K
L
M
E
R
V
I
L
E
CD
E
T
-------------
Q
L
K
D
I
F
Q
-
S
-----
F
-----
N
--
G
------
V
F
F
G
L
S
C
H
K
Y
A
S
H
V
L
E
T
--------------
L
F
V
R
S
A
A
--------
L
V
E
--
R
E
L
L
T
Y
V
T
M
--
E
N
M
------
F
L
F
-
M
L
N
E
L
K
P
H
L
--
K
---------
T
---
M
----------------------------
M
-
N
--------
H
------
Q
-------------
Y
----
A
S
H
V
L
R
L
L
I
L
---
I
L
S
SKTL
P
-----
V
-----
Y
Q
T
P
E
S
--------------------
F
K
S
E
------
L
R
D
I
I
T
-
T
-----
L
Y
K
G
F
T
-------------
N
---
G
A
E
------
S
--------------
R
S
D
I
S
Q
S
T
I
T
----
K
F
------------------------------
R
-----
E
------------
Y
S
V
-----------------
D
--
K
-
V
-----------------
A
S
---
P
----------
V
I
Q
L
----
I
I
--
Q
-----
V
-
E
G
I
F----
D
---
R
-
D
R
S
F
W
R
L
V
F
N
T
A
D
E
K
-
D
P
K
E
--
E
S
F
L
E
Y
L
L
--
S
----
D
------------
P
V
G
S
H
F
L
E
N
-
V
I
G
S
A
R
---
L
K
Y
---
V
E
R
----
L
---------
Y
-
R
L
Y
M
K
D
R
---------
I
V
K
L
A
K
R
D
T
T
G
A
F
V
V
R
A
L
-
L
E
H
LK
E
K
D
V
K
Q
I
L
D
A
--
V
V
PE
L
S
M
L
L
N
S
N
M
D
F
G
T
A
----
I
I
N
T
S
N
K
Q
GGYL
R
D
D
V
I
A
Q
L
I
Q
K
YYP
E
K
S
D
A
K
N
I
L
E
S
-
C
L
L
L
-
S
A
S
T
LG
N
T
R
D
D
W
P
T
A
E
E
R
R
-
R
S
V
F
L
E
Q
L
I
D
Y
D
D
K
F
L
N
I
T
I
D
S
M
L
A
L
P
E
E
R
L
I
Q
M
-----
C
Y
H
G
V
--------
F
S
H
V
V
E
H
V
L
Q
T
T
R
V
D
I
I
K
R
K
M
L
L
N
I
L
S
K
E
S
V
N
L
A
-
C
N
V
Y
G
S
H
I
M
D
K
L
W
E
F
T
A
K
L
T
L
Y
------
K
E
R
I
A
R
A
L
V
L
E
T
E
K
V
K
N
----
S
I
Y
G
R
Q
V
W
K
N
W
K
L
E
L
Y
V
RK
M
W
D
W
K
K
L
I
K
E
Q
E
F
E
I
F
P--------
41
Fugue
42.64
14%
5
- C4 -
-
1SMA
-
?
A:
[1-588]
-----------------------------------------------------------
M
R
K
E
A
I
H
H
--
R
S
TDNFAYAYDSE
T
L
H
L
R
L
Q
T
K
-
K
-----
N
-----
D
--
V
------
D
H
V
E
L
L
--------
F
G
D
PYEWHDG
A
W
Q
F
Q
T
M
P
M
R
K
T
G
S
DGL
F
D
Y
W
L
A
E
V
--
K
P
P
Y
R
R
L
R
Y
--
G
F
V
------
L
R
A
--
G
----
G
E
K
--
L
---------
V
---
Y
T
EKGFYH
E
A
P
S
DDTAY
Y
F
C
FPFLHRVDL
F
-
Q
--------
A
------
P
-------------
D
----
W
V
K
D
T
V
W
Y
Q
I
---
F
P
-----
E
-----
R
-----
F
A
N
G
N
P
AISPKGARPWGSEDPTPTSF
F
G
G
D
------
L
Q
G
I
I
D
H
L
-----
D
Y
L
A
D
L
-------------
G
---
I
T
-
G
I
Y
L
-
T
P
IFRAPSNHKYDTAD
Y
F
E
I
D
P
H
F
G
D
----
K
-------------------------------
E
-----
T
------------
L
K
T
-----------------
L
--
V
-
K
-----------------
R
C
---
H
----------
E
K
G
I
----
R
V
--
M
-----
L
-
D
A
V
FNHCG
Y
---
E
-
F
A
P
F
Q
-
D
V
L
K
N
G
A
A
S
-
R
Y
K
D
--
W
F
H
I
R
E
F
P
--
L
----
Q
----
T
E
P
R
P
N
--
Y
D
T
F
A
F
-
V
P
-
H
M
P
K
L
N
-
T
A
H
P
E
---
V
K
R
----
Y
---------
L
L
D
V
A
T
Y
W
I
R
E
FDID
G
W
R
L
D
V
A
N
E
I
D
H
---
Q
F
W
R
E
F
-
R
Q
-----
A
V
K
A
L
K
P
D
V
Y
I
L
--
G
E
I
W
H
D
A
M
P
W
L
R
G
D
QFDA
V
M
N
Y
P
L
A
D
------
A
A
L
R
F
F
A
K
E
---
D
M
S
A
S
E
F
A
D
R
L
-
M
H
V
L
H
S
Y
P
K
--
Q
V
N
E
A
A
F
N
L
L
G
S
H
-
D
T
P
R
L
L
T
V
C
G
G
--
D
V
R
K
V
K
L
L
F
L
F
Q
L
T
F
T
G
S
P
C
I
Y
Y
G
D
E
I
G
M
T
G
G
N
DPECRK
C
M
V
W
D
P
E
-
K
Q
N
K
E
L
Y
E
H
V
K
Q
L
I
--
A
L
R
K
Q
Y
R
A
L
R
R
G
D
V
-
A
F
L
T
A
D
D
E
V
N
H
L
V
Y
A
K
T
D
GN
E
T
V
M
I
I
I
N
R
S
N
E
A
A
-
E
I
P
M
P
I
----
D
A
-
R
G
K
W
L
V
---
N
L
L
T
GERFAAEAETLC
V
S
L
P
PY
G
F
V
L
Y
A
V
E
S
W
16
PsiBlast_PDB
42.43
24%
-41
- C5 -
-
2AG6
1
SYY_METJA
A:
[29-135]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
A
L
-
I
G
F
E
P
S
G
K
I
-
H
L
G
H
--
Y
L
Q
I
K
K
M
----------------
I
D
L
--
Q
N
A
G
F
D
I
I
I
-
L
L
A
D
----
L
H
A
Y
---
L
N
Q
KG--
E
---------
L
D
E
---------------
I
R
K
I
G
D
Y
N
K
---
K
V
F
E
A
M
---------------
G
--
L
K
--
A
K
Y
V
Y
G
S
S
F
Q
L
D
K
D
----
Y
T
L
N
V
Y
R
L
------
A
L
K
T
T
L
K
R
A
---
R
R
S
M
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
42.25
10%
-14
- C8 -
-
3FCX
-
ESTD_HUMAN
A:
[44-264]
-----------------------------------------------------------------------------------------------------------
K
------
C
P
A
L
Y
W
--------
L
S
G
--------------
L
T
C
T
E
Q
N
--------
F
I
S
KS
G
Y
H
Q
S
A
S
E
H
--
G
L
V
------
V
I
A
-
P
D
----
T
S
P
--
R
GCNIFGTGA
G
---
F
----------------------------
Y
-
V
--------
D
------
A
TEDPWKTNYR---
M
----
Y
S
Y
V
T
E
E
L
P
Q
---
L
I
-----
N
A
N
FPV
D
-----
P
Q
R
M
S
I
--------------------
F
G
H
S
------
M
G
G
H
G
A
-
L
-----
I
C
A
L
K
N
PG-----------
K
---
Y
K
S
V
S
A
F
-
A
P
--------------
I
C
N
P
V
L
C
P
W
G
----
K
-------------------------------
K
-----
A
------------
F
S
G
-----------------
Y
--
L
G------------------
S
K
---
W
----------
K
A
Y
D
----
A
T
--
H
L
----
V
-
K
S
Y
P-----------
L
D
I
L
-
I
D
Q
G
K
D
D
Q
F
L
L
D
G
Q
LL
P
D
N
F
I
A
A
C
--
T
----
E
K
KI
P
V
V
F
R
L
Q
--
E
D
Y
D
H
S
Y
Y
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------