@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ84: (2017-11-25 )
MSDLSYVNEHSDAWQTYLAQIDRVAPYLEHLADYIDTLKRPKRALIVDVPIVMDDGSIQHFEGYRVQHNLSRGPGKGGVRYHPNVDLNEVMALSAWMTIKTAVLNLPFGGAKGGIRVDPRKLSNRELERLTRRYTTEIGHIIGPQKDIPAPDVGTNANIMGWMMDTYSTSQGHTVTGVVTGKPVHLGGSLGRVKATGRGVFVTGREVAAKINLPIEGAKVAVQGFGNVGSEAAFLFVESKAKITHVQDHTGTIFNADGIDLVALRDHVNANQGVGGFAGAQAIADEDFWTAEVDIIIPAALEGQITVERAEKLKAKLILEGANGPTYPKAEDVLVERGIVVVPDVVCNAGGVTVSYFEWVQDMASYFWSEEEINERLDKLMVQAMDDVWNTANKNACTLRTAAYILACERILKARKERGIFPG
Atome Classification :
(21 SA)
.........10.---.......20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.........150.......160.......170.---......180.......190.......200----.........210.-......220........230......-.240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
D
L
S
Y
V
N
EH
S
D
---
A
W
Q
T
Y
L
A
Q
I
D
R
V
A
P
Y
L
E
H
L
A
D
Y
I
D
T
LKRPK
R
A
L
I
V
DV
P
I
V
MDDGS
I
Q
H
FE
G
Y
R
V
QHNLSRGPGKGG
V
R
YHPNV
D
L
N
E
V
M
A
L
S
A
W
M
T
I
K
T
A
V
LNLPFGGAKG
G
I
R
V
D
P
R
KL
S
N
R
E
L
E
R
L
T
R
R
Y
T
T
E
I
G
H
--IIGPQKDIPAPDVGTNA
N
I
M
G
W
M
MDTYSTSQG
H
---
T
V
T
G
V
VTGK
P
V
HLGGSLG
R
V
K
ATG
R
G
V
------
F
V
TG
R
E
V
A
A
K
INL-PIEG
A
K
V
-
A
V
QGFGNVGS
E
A
A
F
L
F
V
E-SK
A
K
I
T
H
VQDHTG
T
I
FNADG
I
D
L
V
A
L
RDHVNANQGVGGFAG
A
Q
A
IADEDF
W
T
A
E
V
D
I
I
I
PAALE
G
Q
I
T
V
E
R
A
E
K
L
K
A
K
L
I
L
EGANGPTYP
K
A
E
D
V
L
V
ERG
I
V
V
V
P
D
VVCNAGG
V
T
V
S
Y
F
E
W
V
Q
D
M
A
S
YFW
S
E
E
E
I
N
E
R
L
D
K
L
M
V
Q
A
M
D
D
V
W
NTANK
N
A
C
T
L
R
T
A
A
Y
I
L
A
C
E
R
I
L
K
A
R
K
ERGIFPG
30
PsiBlast_CBE
95.69
58%
-93
- C8 -
-
3AOG
1
?
I:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
32
PsiBlast_CBE
95.35
58%
-96
- C8 -
-
3AOG
2
?
G:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
2
PsiBlast_PDB
95.21
58%
-92
- C8 -
-
3AOE
3
?
A:
[6-424]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
34
PsiBlast_CBE
95.03
58%
-94
- C8 -
-
3AOG
4
?
E:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
116
HHSearch
94.89
63%
-85
- C8 -
-
4XGI
3
?
C:
[23-436]
--------
D
D
L
G
---
P
W
G
N
Y
L
Q
Q
V
D
R
V
A
P
Y
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
--
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
---
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
------
F
V
V
G
C
E
A
A
K
K
K
G
V
-
E
I
E
G
A
R
I
-
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
E
-
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
G
V
A
G
F
E
G
A
E
P
M
P
N
D
E
F
W
T
V
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
------
W
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
L
Y
P
-
3
PsiBlast_PDB
94.73
58%
-94
- C8 -
-
3AOG
4
?
A:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
37
PsiBlast_CBE
94.66
58%
-92
- C8 -
-
3AOG
4
?
B:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
29
PsiBlast_CBE
94.17
58%
-95
- C8 -
-
3AOG
1
?
J:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
115
HHSearch
94.16
59%
-92
- C8 -
-
3AOE
3
?
B:
[5-424]
--
P
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
26
PsiBlast_CBE
93.99
58%
-93
- C8 -
-
3AOE
3
?
B:
[6-424]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
36
PsiBlast_CBE
93.70
58%
-95
- C8 -
-
3AOG
4
?
C:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
33
PsiBlast_CBE
93.67
58%
-93
- C8 -
-
3AOG
4
?
F:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
35
PsiBlast_CBE
93.64
58%
-92
- C8 -
-
3AOG
4
?
D:
[22-440]
---
L
S
Y
L
G
K
D
G
G
---
P
W
E
I
F
T
E
Q
V
D
R
V
V
P
Y
L
G
R
L
A
P
L
A
E
S
L
K
R
P
K
R
V
L
I
V
D
V
P
V
R
L
D
D
G
S
V
A
Y
F
E
G
Y
R
V
H
H
N
T
A
R
G
P
A
K
G
G
V
R
Y
H
P
E
V
T
L
S
E
V
M
A
L
A
G
W
M
T
I
K
N
A
A
V
G
L
P
Y
G
G
G
K
G
G
I
R
V
D
P
R
K
L
S
P
G
E
L
E
R
L
T
R
R
Y
T
S
E
I
G
I
--
L
L
G
P
D
R
D
I
P
A
P
D
V
N
T
G
E
R
E
M
A
W
M
M
D
T
Y
S
M
N
V
G
R
---
T
V
P
G
V
V
T
G
K
P
I
A
L
G
G
S
L
G
R
R
D
A
T
G
R
G
V
------
F
I
T
A
A
A
A
A
E
K
I
G
L
-
Q
V
E
G
A
R
V
-
A
I
Q
G
F
G
N
V
G
N
A
A
A
R
A
F
H
D
-
H
G
A
R
V
V
A
V
Q
D
H
T
G
T
V
Y
N
E
A
G
I
D
P
Y
D
L
L
R
H
V
Q
E
F
G
G
V
R
G
Y
P
K
A
E
P
L
P
A
A
D
F
W
G
L
P
V
E
F
L
V
P
A
A
L
E
K
Q
I
T
E
Q
N
A
W
R
I
R
A
R
I
V
A
E
G
A
N
G
P
T
T
P
A
A
D
D
I
L
L
E
K
G
V
L
V
V
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
F
N
S
Y
F
W
T
E
E
E
I
N
A
R
L
E
R
V
L
R
N
A
F
E
A
V
W
Q
V
A
Q
E
K
K
I
P
L
R
T
A
A
Y
V
V
A
A
T
R
V
L
E
A
R
A
L
R
G
L
Y
P
-
23
PsiBlast_CBE
85.24
63%
10
- C8 -
-
4XGI
3
?
D:
[21-436]
---------
H
A
D
DLG
P
W
G
N
Y
L
Q
Q
V
D
R
V
A
P
Y
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
--
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
---
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
------
F
V
V
G
C
E
A
A
K
K
K
G
V
-
E
I
E
G
A
R
I
-
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
E
-
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
G
V
A
G
F
E
G
A
E
P
M
P
N
D
E
F
W
T
V
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
-------
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
L
Y
P
-
128
HHSearch
85.15
43%
-87
- C8 -
-
3K92
1
DHE2_BACSU
A:
[14-424]
---------
A
L
N
---
L
F
L
S
T
Q
T
I
I
K
E
A
L
R
K
L
G
Y
P
G
D
M
Y
E
L
M
K
E
P
Q
R
M
L
T
V
R
I
P
V
K
M
D
N
G
S
V
K
V
F
T
G
Y
R
S
Q
H
N
D
A
V
G
P
T
K
G
G
V
R
F
H
P
E
V
N
E
E
K
V
K
A
L
S
I
W
M
T
L
K
C
G
I
A
N
L
P
Y
G
G
G
K
G
G
I
I
C
D
P
R
T
M
S
F
G
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
--
I
V
G
P
T
K
D
I
P
A
P
D
V
Y
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
L
R
E
F
---
D
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
Q
G
R
E
T
A
T
A
Q
G
V
------
T
I
C
I
E
E
A
V
K
K
K
G
I
-
K
L
Q
N
A
R
I
-
I
I
Q
G
F
G
N
A
G
S
F
L
A
K
F
M
H
D
-
A
G
A
K
V
I
G
I
S
D
A
N
G
G
L
Y
N
P
D
G
L
D
I
P
Y
L
L
D
K
R
D
S
F
G
M
V
T
N
L
F
T
-
D
V
I
T
N
E
E
L
L
E
K
D
C
D
I
L
V
P
A
A
I
S
N
Q
I
T
A
K
N
A
H
N
I
Q
A
S
I
V
V
E
R
A
N
G
P
T
T
I
D
A
T
K
I
L
N
E
R
G
V
L
L
V
P
D
I
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
Y
Y
W
S
E
E
E
V
A
E
K
L
R
S
V
M
V
S
S
F
E
T
I
Y
Q
T
A
A
T
H
K
V
D
M
R
L
A
A
Y
M
T
G
I
R
K
S
A
E
A
S
R
F
R
G
W
V
--
24
PsiBlast_CBE
84.47
63%
6
- C8 -
-
4XGI
3
?
C:
[21-436]
---------
H
A
D
DLG
P
W
G
N
Y
L
Q
Q
V
D
R
V
A
P
Y
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
--
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
---
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
------
F
V
V
G
C
E
A
A
K
K
K
G
V
-
E
I
E
G
A
R
I
-
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
E
-
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
G
V
A
G
F
E
G
A
E
P
M
P
N
D
E
F
W
T
V
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
------
W
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
L
Y
P
-
117
HHSearch
84.42
52%
-29
* C8 *
-
2TMG
-
DHE3_THEMA
B:
[4-411]
-----------
S
---
L
Y
E
M
A
V
E
Q
F
N
R
A
A
S
L
M
D
L
E
S
D
L
A
E
V
L
R
R
P
K
R
V
L
I
V
E
F
P
V
R
M
D
D
G
H
V
E
V
F
T
G
Y
R
V
Q
H
N
V
A
R
G
P
A
K
G
G
I
R
Y
H
P
D
V
T
L
D
E
V
K
A
L
A
F
W
M
T
W
K
T
A
V
M
N
L
P
F
G
G
G
K
G
G
V
R
V
D
P
K
K
L
S
R
R
E
L
E
R
L
S
R
R
F
F
R
E
I
Q
V
--
I
I
G
P
Y
N
D
I
P
A
P
D
V
N
T
N
A
D
V
I
A
W
Y
M
D
E
Y
E
M
N
V
G
H
---
T
V
L
G
I
V
T
G
K
P
V
E
L
G
G
S
K
G
R
E
E
A
T
G
R
G
V
------
K
V
C
A
G
L
A
M
D
V
L
G
I
-
D
P
K
K
A
T
V
-
A
V
Q
G
F
G
N
V
G
Q
F
A
A
L
L
I
S
Q
E
L
G
S
K
V
V
A
V
S
D
S
R
G
G
I
Y
N
P
E
G
F
D
V
E
E
L
I
R
Y
K
K
E
H
G
T
V
V
T
Y
P
K
G
E
R
I
T
N
E
E
L
L
E
L
D
V
D
I
L
V
P
A
A
L
E
G
A
I
H
A
G
N
A
E
R
I
K
A
K
A
V
V
E
G
A
N
G
P
T
T
P
E
A
D
E
I
L
S
R
R
G
I
L
V
V
P
D
I
L
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
D
L
Q
S
F
F
W
D
L
D
Q
V
R
N
A
L
E
K
M
M
K
G
A
F
N
D
V
M
K
V
K
E
K
Y
N
V
D
M
R
T
A
A
Y
I
L
A
I
D
R
V
A
Y
A
T
K
K
R
-----
1
PsiBlast_PDB
84.38
63%
9
- C8 -
-
4XGI
3
?
A:
[21-436]
---------
H
A
D
DLG
P
W
G
N
Y
L
Q
Q
V
D
R
V
A
P
Y
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
--
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
---
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
------
F
V
V
G
C
E
A
A
K
K
K
G
V
-
E
I
E
G
A
R
I
-
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
E
-
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
G
V
A
G
F
E
G
A
E
P
M
P
N
D
E
F
W
T
V
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
------
W
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
L
Y
P
-
25
PsiBlast_CBE
84.34
63%
9
- C8 -
-
4XGI
3
?
B:
[21-436]
---------
H
A
D
DLG
P
W
G
N
Y
L
Q
Q
V
D
R
V
A
P
Y
L
G
S
L
S
R
W
I
E
T
L
K
R
P
K
R
I
L
I
V
D
V
P
I
E
L
D
N
G
T
V
A
H
F
E
G
Y
R
V
Q
H
N
V
S
R
G
P
G
K
G
G
V
R
Y
H
Q
D
V
T
L
S
E
V
M
A
L
S
A
W
M
S
V
K
N
A
A
V
N
V
P
Y
G
G
A
K
G
G
I
R
V
D
P
R
K
L
S
R
G
E
L
E
R
V
T
R
R
Y
T
S
E
I
G
I
--
I
I
G
P
N
T
D
I
P
A
P
D
V
N
T
N
E
Q
I
M
A
W
M
M
D
T
Y
S
M
N
Q
G
Q
---
T
A
T
G
V
V
T
G
K
P
I
S
L
G
G
S
L
G
R
K
E
A
T
G
R
G
V
------
F
V
V
G
C
E
A
A
K
K
K
G
V
-
E
I
E
G
A
R
I
-
A
V
Q
G
F
G
N
V
G
G
I
A
A
K
L
F
Q
E
-
A
G
A
K
V
I
A
V
Q
D
H
T
G
T
I
H
Q
P
A
G
V
D
T
A
K
L
L
D
H
V
G
R
T
G
G
V
A
G
F
E
G
A
E
P
M
P
N
D
E
F
W
T
V
E
T
E
I
L
I
P
A
A
L
E
N
Q
I
T
E
K
N
A
S
K
I
R
T
K
I
I
V
E
G
A
N
G
P
T
T
T
A
A
D
D
I
L
S
A
N
G
V
L
V
I
P
D
V
I
A
N
A
G
G
V
T
V
S
Y
F
E
W
V
Q
-------
T
E
D
E
I
N
H
R
L
E
R
V
M
R
E
A
F
A
G
V
W
A
V
A
E
E
H
K
V
S
V
R
T
A
A
F
I
V
A
C
K
R
I
L
M
A
R
E
M
R
G
L
Y
P
-
11
PsiBlast_PDB
84.27
44%
-95
- C8 -
-
3K8Z
-
GUDB_BACSU
A:
[17-421]
---------------
V
L
K
S
T
Q
T
V
I
H
K
A
L
E
K
L
G
Y
P
E
E
V
Y
E
L
L
K
E
P
M
R
L
L
T
V
K
I
P
V
R
M
D
D
G
S
V
K
I
F
T
G
Y
R
A
-
H
N
D
S
V
G
P
T
K
G
G
I
R
F
H
P
N
V
T
E
K
E
V
K
A
L
S
I
W
M
S
L
K
C
G
I
I
D
L
P
Y
G
G
G
K
G
G
I
V
C
D
P
R
D
M
S
F
R
E
L
E
R
L
S
R
G
Y
V
R
A
I
S
Q
--
I
V
G
P
T
K
D
V
P
A
P
D
V
F
T
N
S
Q
I
M
A
W
M
M
D
E
Y
S
R
I
D
E
F
---
N
S
P
G
F
I
T
G
K
P
L
V
L
G
G
S
H
G
R
E
S
A
T
A
K
G
V
------
T
I
C
I
K
E
A
A
K
K
R
G
I
-
D
I
K
G
A
R
V
-
V
V
Q
G
F
G
N
A
G
S
Y
L
A
K
F
M
H
D
-
A
G
A
K
V
V
G
I
S
D
A
Y
G
G
L
Y
D
P
E
G
L
D
I
D
------------------------------
C
D
I
L
V
P
A
A
I
E
N
Q
I
T
E
E
N
A
H
N
I
R
A
K
I
V
V
E
A
A
N
G
P
T
T
L
E
G
T
K
I
L
S
D
R
D
I
L
L
V
P
D
V
L
A
S
A
G
G
V
T
V
S
Y
F
E
W
V
Q
N
N
Q
G
F
Y
W
S
E
E
E
V
E
E
K
L
E
K
M
M
V
K
S
F
N
N
I
Y
E
M
A
N
N
R
R
I
D
M
R
L
A
A
Y
M
V
G
V
R
K
M
A
E
A
S
R
F
R
G
----
85
PsiBlast_CBE
58.25
43%
3
- C8 -
-
3QMU
11
DHE3_BOVIN
L:
[52-389]
----------------------------------------
I
K
P
C
N
H
V
L
S
L
S
F
P
I
R
R
D
D
G
S
W
E
V
I
E
G
Y
R
A
Q
H
S
Q
H
R
T
P
C
K
G
G
I
R
Y
S
T
D
V
S
V
D
E
V
K
A
L
A
S
L
M
T
Y
K
C
A
V
V
D
V
P
F
G
G
A
K
A
G
V
K
I
N
P
K
N
Y
T
D
N
E
L
E
K
I
T
R
R
F
T
M
E
L
A
K
KG
F
I
G
P
G
V
D
V
P
A
P
D
M
S
T
G
E
R
E
M
S
W
I
A
D
T
Y
A
S
T
I
G
H
YDI
N
A
H
A
C
V
T
G
K
P
I
S
Q
G
G
I
H
G
R
I
S
A
T
G
R
G
V
FHGIEN
F
I
N
E
A
S
Y
M
S
I
L
G
M
T
P
G
F
G
D
K
T
F
V
V
Q
G
F
G
N
V
G
L
H
S
M
R
Y
L
H
R
-
F
G
A
K
C
I
T
V
G
E
S
D
G
S
I
W
N
P
D
G
I
D
P
K
E
L
E
D
F
K
L
Q
H
G
T
I
L
G
F
P
K
A
K
-
I
Y
E
G
S
I
L
E
V
D
C
D
I
L
I
P
A
A
S
E
K
Q
L
T
K
S
N
A
P
R
V
K
A
K
I
I
A
E
G
A
N
G
P
T
T
P
E
A
D
K
I
F
L
E
R
N
I
M
V
I
P
D
L
Y
L
N
A
G
G
V
T
V
S
Y
F
E
W
L
N
N
L
------------------------------------------------------------