@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQ87: (2017-11-25 )
MSNSLFINGVWLQGSGTTFVKTNPVDNQTVWSGAEATASDVEKACQAARTAFPAWARLAFAERVAIVEKFAALLEENKKHLAEVISQETSKPFWETLTEVQSMIGKVAISIRAYHQRTGESSTEMADGVASLRHRPHGVLAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPWTAEETVKLWQQAGLPNGVMNLVQGGRTTGEALAASHEIDGLLFTGSANTGYHLHKQMAGAPEKILALEMGGNNALIIDEIENMDAVVNLTIQSAFVSAGQRCTCARRILVKNGAQGDAFIQRFVEVAKNLKVGRWNDEQQPFMGGVISSAAATNMMNAQQKLLELGAKSLLPMTRPQEDSSLLTPGIIDVTGVAGIPDEEYFGPLTTIQRYDSFDEALKIANATRFGLSVGLVSPKRELFDDLLIEARAGIVNWNKPLTGASSAAPFGGVGASGNHRASAFYAADYCAWPMASLESESLTLPEKLSPGIVLP
Atome Classification :
(20 SA)
.........10...-.....-20........30........40........50.---.--......60........70........80.......---.90-......-..100.......110.......--120......--.130.......140.......150.......160.......170.......180.......190.......200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350---.......-----360..-.-....370.......380.......390.......400.......410.......420.......430.......440.......450....---...460-........470.......480.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSN
S
L
F
I
N
G
V
W
LQG-SG
T
T
F
-
V
K
TNPVDNQTVWSGAEA
T
A
S
D
V
E
K
A
C
Q
A
A
R
TA
F
---
P
--
A
W
A
R
L
A
F
A
E
R
V
A
I
V
E
K
F
A
A
L
L
E
E
N
K
K
H
L
A
E
V
I
S
Q
E---TSK-
P
F
W
E
T
L
-
T
E
V
Q
S
M
I
G
K
V
A
I
S
I
R
A
Y
H
QRTG--ES
S
T
E
M
A
D
G
--
V
A
S
L
RHRPH
G
V
L
A
V
FGPYNFPGHLPNG
H
I
V
P
A
L
LAG
N
T
V
V
F
KPSELTPW
T
A
E
E
T
V
K
L
W
Q
QAGL
P
N
G
V
M
N
L
V
QG-GRTT
G
E
A
L
AASHEI
D
G
L
L
F
TGSANT
G
Y
H
L
H
K
Q
MAGAP
E
K
I
L
A
L
E
MGGN
N
A
L
I
I
DEIENM
D
A
V
V
N
L
T
I
Q
S
A
F
V
SAGQ
R
C
T
C
A
R
R
I
L
VKNGAQ
G
D
A
F
I
Q
R
F
V
E
V
A
KNLKVGRWNDEQQP
F
M
G
G
V
I
S
S
A
A
A
T
N
M
M
N
A
Q
Q
K
L
L
E
L
G
A
K
SLLPMTR---PQEDSSL-----LTPG
I
-
I
-
D
VTGVAGIPDEEYFG
P
L
T
T
I
Q
R
Y
D
S
F
D
E
A
L
K
I
A
NA
T
R
F
G
L
S
VGLVS
P
K
R
E
L
F
D
D
L
L
I
E
ARAGIVNWNKPLTGASSAAPFGGVGASGNHR
A
S
---
A
F
Y
A-
A
-
D
YCAW
P
M
A
SLESESLTLPEKLSPGIVLP
82
HHSearch
99.24
60%
-80
- C3 -
-
3JU8
5
ASTD_PSEAE
B:
[5-489]
-
M
S
T
H
Y
I
A
G
Q
W
L
A
G
-
Q
G
E
T
L
-
E
S
L
D
P
V
G
Q
G
V
V
W
S
G
R
G
A
D
A
T
Q
V
D
A
A
V
C
A
A
R
E
A
F
---
P
--
A
W
A
R
R
P
L
E
Q
R
I
E
L
L
E
R
F
A
A
T
L
K
S
R
A
D
E
L
A
R
V
I
G
E
E
---
T
G
K
-
P
L
W
E
S
A
-
T
E
V
T
S
M
V
N
K
V
A
I
S
V
Q
A
F
R
E
R
T
G
--
E
K
S
G
P
L
A
D
A
--
T
A
V
L
R
H
K
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
C
V
V
F
K
P
S
E
L
T
P
K
V
A
E
L
T
L
K
A
W
I
Q
A
G
L
P
A
G
V
L
N
L
V
Q
G
-
G
R
E
T
G
V
A
L
A
A
H
R
G
L
D
G
L
F
F
T
G
S
S
R
T
G
N
L
L
H
S
Q
F
G
G
Q
P
Q
K
I
L
A
L
E
M
G
G
N
N
P
L
V
V
E
E
V
A
D
L
D
A
A
V
Y
T
I
I
Q
S
A
F
I
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
Q
G
A
W
G
D
A
L
L
A
R
L
V
A
V
S
A
T
L
R
V
G
R
F
D
E
Q
P
A
P
F
M
G
A
V
I
S
L
S
A
A
E
H
L
L
K
A
Q
E
H
L
I
G
K
G
A
Q
P
L
L
A
M
T
Q
---
P
I
D
G
A
A
L
-----
L
T
P
G
I
-
L
-
D
V
S
A
V
A
E
R
P
D
E
E
F
F
G
P
L
L
Q
V
I
R
Y
S
D
F
A
A
A
I
R
E
A
N
A
T
Q
Y
G
L
A
A
G
L
L
S
D
S
R
E
R
F
E
Q
F
L
V
E
S
R
A
G
I
V
N
W
N
K
Q
L
T
G
A
A
S
S
A
P
F
G
G
I
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
Y
P
V
A
S
L
E
S
P
S
V
S
L
P
A
T
L
T
P
G
I
---
83
HHSearch
97.67
60%
-81
- C3 -
-
3JU8
9
ASTD_PSEAE
A:
[4-489]
M
M
S
T
H
Y
I
A
G
Q
W
L
A
G
-
Q
G
E
T
L
-
E
S
L
D
P
V
G
Q
G
V
V
W
S
G
R
G
A
D
A
T
Q
V
D
A
A
V
C
A
A
R
E
A
F
---
P
--
A
W
A
R
R
P
L
E
Q
R
I
E
L
L
E
R
F
A
A
T
L
K
S
R
A
D
E
L
A
R
V
I
G
E
E
---
T
G
K
-
P
L
W
E
S
A
-
T
E
V
T
S
M
V
N
K
V
A
I
S
V
Q
A
F
R
E
R
T
G
--
E
K
S
G
P
L
A
D
A
--
T
A
V
L
R
H
K
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
C
V
V
F
K
P
S
E
L
T
P
K
V
A
E
L
T
L
K
A
W
I
Q
A
G
L
P
A
G
V
L
N
L
V
Q
G
-
G
R
E
T
G
V
A
L
A
A
H
R
G
L
D
G
L
F
F
T
G
S
S
R
T
G
N
L
L
H
S
Q
F
G
G
Q
P
Q
K
I
L
A
L
E
M
G
G
N
N
P
L
V
V
E
E
V
A
D
L
D
A
A
V
Y
T
I
I
Q
S
A
F
I
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
Q
G
A
W
G
D
A
L
L
A
R
L
V
A
V
S
A
T
L
R
V
G
R
F
D
E
Q
P
A
P
F
M
G
A
V
I
S
L
S
A
A
E
H
L
L
K
A
Q
E
H
L
I
G
K
G
A
Q
P
L
L
A
M
T
Q
---
P
I
D
G
A
A
L
-----
L
T
P
G
I
-
L
-
D
V
S
A
V
A
E
R
P
D
E
E
F
F
G
P
L
L
Q
V
I
R
Y
S
D
F
A
A
A
I
R
E
A
N
A
T
Q
Y
G
L
A
A
G
L
L
S
D
S
R
E
R
F
E
Q
F
L
V
E
S
R
A
G
I
V
N
W
N
K
Q
L
T
G
A
A
S
S
A
P
F
G
G
I
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
Y
P
V
A
S
L
E
S
P
S
V
S
L
P
A
T
L
T
P
G
I
---
3
PsiBlast_PDB
97.14
59%
-83
- C3 -
-
3JU8
9
ASTD_PSEAE
A:
[9-489]
-----
Y
I
A
G
Q
W
L
A
G
-
Q
G
E
T
L
-
E
S
L
D
P
V
G
Q
G
V
V
W
S
G
R
G
A
D
A
T
Q
V
D
A
A
V
C
A
A
R
E
A
F
---
P
--
A
W
A
R
R
P
L
E
Q
R
I
E
L
L
E
R
F
A
A
T
L
K
S
R
A
D
E
L
A
R
V
I
G
E
E
---
T
G
K
-
P
L
W
E
S
A
-
T
E
V
T
S
M
V
N
K
V
A
I
S
V
Q
A
F
R
E
R
T
G
--
E
K
S
G
P
L
A
D
A
--
T
A
V
L
R
H
K
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
C
V
V
F
K
P
S
E
L
T
P
K
V
A
E
L
T
L
K
A
W
I
Q
A
G
L
P
A
G
V
L
N
L
V
Q
G
-
G
R
E
T
G
V
A
L
A
A
H
R
G
L
D
G
L
F
F
T
G
S
S
R
T
G
N
L
L
H
S
Q
F
G
G
Q
P
Q
K
I
L
A
L
E
M
G
G
N
N
P
L
V
V
E
E
V
A
D
L
D
A
A
V
Y
T
I
I
Q
S
A
F
I
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
Q
G
A
W
G
D
A
L
L
A
R
L
V
A
V
S
A
T
L
R
V
G
R
F
D
E
Q
P
A
P
F
M
G
A
V
I
S
L
S
A
A
E
H
L
L
K
A
Q
E
H
L
I
G
K
G
A
Q
P
L
L
A
M
T
Q
---
P
I
D
G
A
A
L
-----
L
T
P
G
I
-
L
-
D
V
S
A
V
A
E
R
P
D
E
E
F
F
G
P
L
L
Q
V
I
R
Y
S
D
F
A
A
A
I
R
E
A
N
A
T
Q
Y
G
L
A
A
G
L
L
S
D
S
R
E
R
F
E
Q
F
L
V
E
S
R
A
G
I
V
N
W
N
K
Q
L
T
G
A
A
S
S
A
P
F
G
G
I
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
Y
P
V
A
S
L
E
S
P
S
V
S
L
P
A
T
L
T
P
G
I
---
21
PsiBlast_CBE
96.92
59%
-78
- C3 -
-
5U0M
3
ASTD_MARHV
B:
[10-494]
L
T
G
N
V
Y
I
D
G
L
W
L
P
G
-
H
G
A
P
F
-
E
S
V
Q
P
V
T
G
E
T
V
W
D
G
N
A
A
S
L
E
D
V
D
A
A
V
R
E
A
R
K
A
F
---
L
--
A
W
R
R
K
S
L
A
E
R
Q
A
V
I
E
A
F
G
E
L
L
E
A
N
K
E
E
L
A
H
Q
I
G
L
E
---
T
G
K
-
P
L
W
E
S
R
-
T
E
V
A
A
M
M
G
K
I
P
I
S
V
K
A
Y
N
E
R
T
G
--
H
T
E
S
D
V
A
G
G
--
H
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
T
V
V
F
K
P
S
E
L
T
P
G
V
A
E
L
T
V
R
L
W
E
K
A
G
L
P
D
G
V
I
N
L
V
Q
G
-
G
S
D
T
G
K
C
L
A
R
H
S
L
I
D
G
L
F
F
T
G
S
S
T
V
G
H
L
L
H
E
Q
F
G
G
Q
P
E
K
I
L
A
L
E
M
G
G
N
N
P
L
I
V
Q
N
V
S
D
L
D
G
A
V
H
H
A
L
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
K
G
K
K
G
D
E
F
L
A
R
L
V
E
V
A
A
R
I
T
V
A
E
F
D
A
D
P
Q
P
F
M
G
S
V
I
S
A
E
A
A
N
Q
L
L
K
A
Q
A
A
M
L
E
K
G
A
T
S
L
L
E
M
K
Q
---
L
K
P
D
T
G
L
-----
L
S
P
G
I
-
V
-
D
A
T
G
I
E
-
L
E
D
Q
E
F
F
G
P
L
L
T
V
Y
R
Y
K
G
F
D
E
A
L
E
L
A
N
N
T
R
Y
G
L
S
A
G
I
L
S
D
D
R
K
L
Y
N
R
L
V
E
E
V
R
A
G
I
V
N
W
N
R
P
L
T
G
A
S
S
A
A
P
F
G
G
V
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
W
P
M
A
S
L
E
A
G
K
S
E
L
P
D
S
L
A
P
G
L
---
1
PsiBlast_PDB
96.61
59%
-78
- C3 -
-
5U0L
10
ASTD_MARHV
A:
[10-494]
L
T
G
N
V
Y
I
D
G
L
W
L
P
G
-
H
G
A
P
F
-
E
S
V
Q
P
V
T
G
E
T
V
W
D
G
N
A
A
S
L
E
D
V
D
A
A
V
R
E
A
R
K
A
F
---
L
--
A
W
R
R
K
S
L
A
E
R
Q
A
V
I
E
A
F
G
E
L
L
E
A
N
K
E
E
L
A
H
Q
I
G
L
E
---
T
G
K
-
P
L
W
E
S
R
-
T
E
V
A
A
M
M
G
K
I
P
I
S
V
K
A
Y
N
E
R
T
G
--
H
T
E
S
D
V
A
G
G
--
H
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
T
V
V
F
K
P
S
E
L
T
P
G
V
A
E
L
T
V
R
L
W
E
K
A
G
L
P
D
G
V
I
N
L
V
Q
G
-
G
S
D
T
G
K
C
L
A
R
H
S
L
I
D
G
L
F
F
T
G
S
S
T
V
G
H
L
L
H
E
Q
F
G
G
Q
P
E
K
I
L
A
L
E
M
G
G
N
N
P
L
I
V
Q
N
V
S
D
L
D
G
A
V
H
H
A
L
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
K
G
K
K
G
D
E
F
L
A
R
L
V
E
V
A
A
R
I
T
V
A
E
F
D
A
D
P
Q
P
F
M
G
S
V
I
S
A
E
A
A
N
Q
L
L
K
A
Q
A
A
M
L
E
K
G
A
T
S
L
L
E
M
K
Q
---
L
K
P
D
T
G
L
-----
L
S
P
G
I
-
V
-
D
A
T
G
I
E
-
L
E
D
Q
E
F
F
G
P
L
L
T
V
Y
R
Y
K
G
F
D
E
A
L
E
L
A
N
N
T
R
Y
G
L
S
A
G
I
L
S
D
D
R
K
L
Y
N
R
L
V
E
E
V
R
A
G
I
V
N
W
N
R
P
L
T
G
A
S
S
A
A
P
F
G
G
V
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
W
P
M
A
S
L
E
A
G
K
S
E
L
P
D
S
L
A
P
G
L
---
85
HHSearch
96.51
59%
-75
- C3 -
-
5U0M
4
ASTD_MARHV
A:
[11-495]
-
T
G
N
V
Y
I
D
G
L
W
L
P
G
-
H
G
A
P
F
-
E
S
V
Q
P
V
T
G
E
T
V
W
D
G
N
A
A
S
L
E
D
V
D
A
A
V
R
E
A
R
K
A
F
---
L
--
A
W
R
R
K
S
L
A
E
R
Q
A
V
I
E
A
F
G
E
L
L
E
A
N
K
E
E
L
A
H
Q
I
G
L
E
---
T
G
K
-
P
L
W
E
S
R
-
T
E
V
A
A
M
M
G
K
I
P
I
S
V
K
A
Y
N
E
R
T
G
--
H
T
E
S
D
V
A
G
G
--
H
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
T
V
V
F
K
P
S
E
L
T
P
G
V
A
E
L
T
V
R
L
W
E
K
A
G
L
P
D
G
V
I
N
L
V
Q
G
-
G
S
D
T
G
K
C
L
A
R
H
S
L
I
D
G
L
F
F
T
G
S
S
T
V
G
H
L
L
H
E
Q
F
G
G
Q
P
E
K
I
L
A
L
E
M
G
G
N
N
P
L
I
V
Q
N
V
S
D
L
D
G
A
V
H
H
A
L
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
K
G
K
K
G
D
E
F
L
A
R
L
V
E
V
A
A
R
I
T
V
A
E
F
D
A
D
P
Q
P
F
M
G
S
V
I
S
A
E
A
A
N
Q
L
L
K
A
Q
A
A
M
L
E
K
G
A
T
S
L
L
E
M
K
Q
---
L
K
P
D
T
G
L
-----
L
S
P
G
I
-
V
-
D
A
-
T
G
I
E
L
E
D
Q
E
F
F
G
P
L
L
T
V
Y
R
Y
K
G
F
D
E
A
L
E
L
A
N
N
T
R
Y
G
L
S
A
G
I
L
S
D
D
R
K
L
Y
N
R
L
V
E
E
V
R
A
G
I
V
N
W
N
R
P
L
T
G
A
S
S
A
A
P
F
G
G
V
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
W
P
M
A
S
L
E
A
G
K
S
E
L
P
D
S
L
A
P
G
L
N
--
2
PsiBlast_PDB
96.21
59%
-76
- C3 -
-
5U0M
4
ASTD_MARHV
A:
[10-494]
L
T
G
N
V
Y
I
D
G
L
W
L
P
G
-
H
G
A
P
F
-
E
S
V
Q
P
V
T
G
E
T
V
W
D
G
N
A
A
S
L
E
D
V
D
A
A
V
R
E
A
R
K
A
F
---
L
--
A
W
R
R
K
S
L
A
E
R
Q
A
V
I
E
A
F
G
E
L
L
E
A
N
K
E
E
L
A
H
Q
I
G
L
E
---
T
G
K
-
P
L
W
E
S
R
-
T
E
V
A
A
M
M
G
K
I
P
I
S
V
K
A
Y
N
E
R
T
G
--
H
T
E
S
D
V
A
G
G
--
H
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
T
V
V
F
K
P
S
E
L
T
P
G
V
A
E
L
T
V
R
L
W
E
K
A
G
L
P
D
G
V
I
N
L
V
Q
G
-
G
S
D
T
G
K
C
L
A
R
H
S
L
I
D
G
L
F
F
T
G
S
S
T
V
G
H
L
L
H
E
Q
F
G
G
Q
P
E
K
I
L
A
L
E
M
G
G
N
N
P
L
I
V
Q
N
V
S
D
L
D
G
A
V
H
H
A
L
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
K
G
K
K
G
D
E
F
L
A
R
L
V
E
V
A
A
R
I
T
V
A
E
F
D
A
D
P
Q
P
F
M
G
S
V
I
S
A
E
A
A
N
Q
L
L
K
A
Q
A
A
M
L
E
K
G
A
T
S
L
L
E
M
K
Q
---
L
K
P
D
T
G
L
-----
L
S
P
G
I
-
V
-
D
A
T
G
I
E
-
L
E
D
Q
E
F
F
G
P
L
L
T
V
Y
R
Y
K
G
F
D
E
A
L
E
L
A
N
N
T
R
Y
G
L
S
A
G
I
L
S
D
D
R
K
L
Y
N
R
L
V
E
E
V
R
A
G
I
V
N
W
N
R
P
L
T
G
A
S
S
A
A
P
F
G
G
V
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
W
P
M
A
S
L
E
A
G
K
S
E
L
P
D
S
L
A
P
G
L
---
81
HHSearch
95.88
58%
-77
- C3 -
-
4KNA
2
ASTD_BURTA
A:
[10-494]
--
T
E
L
F
I
D
G
A
W
V
D
G
-
A
G
P
V
F
-
A
S
R
N
P
G
T
N
E
R
V
W
E
G
A
S
A
S
A
D
D
V
E
R
A
V
A
S
A
R
R
A
F
---
A
--
A
W
S
A
L
D
L
D
A
R
C
T
I
V
K
R
F
A
A
L
L
V
E
R
K
E
A
L
A
T
M
I
G
R
E
---
T
G
K
-
P
L
W
E
A
R
-
T
E
V
A
S
M
A
A
K
V
D
I
S
I
T
A
Y
H
E
R
T
G
--
E
K
R
A
P
M
A
D
G
--
V
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
I
A
G
N
T
V
V
F
K
P
S
E
L
A
P
G
V
A
R
A
T
V
E
I
W
R
D
A
G
L
P
A
G
V
L
N
L
V
Q
G
-
E
K
D
T
G
V
A
L
A
N
H
R
Q
I
D
G
L
F
F
T
G
S
S
D
T
G
T
L
L
H
K
Q
F
G
G
R
P
E
I
V
L
A
L
E
M
G
G
N
N
P
L
V
V
A
E
V
E
D
I
D
A
A
V
H
H
A
I
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
I
L
V
P
R
G
A
F
G
D
R
F
V
A
R
L
A
D
V
A
S
K
I
T
A
S
V
F
D
A
D
P
Q
P
F
M
G
A
V
I
S
A
R
A
A
S
R
L
V
A
A
Q
A
R
L
V
G
L
G
A
S
P
I
I
E
M
K
Q
---
R
D
P
A
L
G
F
-----
V
N
A
A
I
-
L
-
D
V
T
N
V
R
E
L
P
D
E
E
H
F
G
P
L
A
Q
I
V
R
Y
T
D
L
D
D
A
I
A
R
A
N
D
T
A
F
G
L
S
A
G
L
L
A
D
D
E
Q
A
W
H
T
F
R
R
A
I
R
A
G
I
V
N
W
N
R
P
T
N
G
A
S
S
A
A
P
F
G
G
A
G
R
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
Y
P
M
A
S
V
E
S
A
Q
L
Q
M
P
A
S
L
S
P
G
L
H
--
4
PsiBlast_PDB
95.62
58%
-79
- C3 -
-
4KNA
2
ASTD_BURTA
A:
[12-493]
----
L
F
I
D
G
A
W
V
D
G
-
A
G
P
V
F
-
A
S
R
N
P
G
T
N
E
R
V
W
E
G
A
S
A
S
A
D
D
V
E
R
A
V
A
S
A
R
R
A
F
---
A
--
A
W
S
A
L
D
L
D
A
R
C
T
I
V
K
R
F
A
A
L
L
V
E
R
K
E
A
L
A
T
M
I
G
R
E
---
T
G
K
-
P
L
W
E
A
R
-
T
E
V
A
S
M
A
A
K
V
D
I
S
I
T
A
Y
H
E
R
T
G
--
E
K
R
A
P
M
A
D
G
--
V
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
I
A
G
N
T
V
V
F
K
P
S
E
L
A
P
G
V
A
R
A
T
V
E
I
W
R
D
A
G
L
P
A
G
V
L
N
L
V
Q
G
-
E
K
D
T
G
V
A
L
A
N
H
R
Q
I
D
G
L
F
F
T
G
S
S
D
T
G
T
L
L
H
K
Q
F
G
G
R
P
E
I
V
L
A
L
E
M
G
G
N
N
P
L
V
V
A
E
V
E
D
I
D
A
A
V
H
H
A
I
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
I
L
V
P
R
G
A
F
G
D
R
F
V
A
R
L
A
D
V
A
S
K
I
T
A
S
V
F
D
A
D
P
Q
P
F
M
G
A
V
I
S
A
R
A
A
S
R
L
V
A
A
Q
A
R
L
V
G
L
G
A
S
P
I
I
E
M
K
Q
---
R
D
P
A
L
G
F
-----
V
N
A
A
I
-
L
-
D
V
T
N
V
R
E
L
P
D
E
E
H
F
G
P
L
A
Q
I
V
R
Y
T
D
L
D
D
A
I
A
R
A
N
D
T
A
F
G
L
S
A
G
L
L
A
D
D
E
Q
A
W
H
T
F
R
R
A
I
R
A
G
I
V
N
W
N
R
P
T
N
G
A
S
S
A
A
P
F
G
G
A
G
R
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
Y
P
M
A
S
V
E
S
A
Q
L
Q
M
P
A
S
L
S
P
G
L
---
84
HHSearch
95.55
59%
-75
- C3 -
-
5U0L
5
ASTD_MARHV
B:
[11-495]
-
T
G
N
V
Y
I
D
G
L
W
L
P
G
-
H
G
A
P
F
-
E
S
V
Q
P
V
T
G
E
T
V
W
D
G
N
A
A
S
L
E
D
V
D
A
A
V
R
E
A
R
K
A
F
---
L
--
A
W
R
R
K
S
L
A
E
R
Q
A
V
I
E
A
F
G
E
L
L
E
A
N
K
E
E
L
A
H
Q
I
G
L
E
---
T
G
K
-
P
L
W
E
S
R
-
T
E
V
A
A
M
M
G
K
I
P
I
S
V
K
A
Y
N
E
R
T
G
--
H
T
E
S
D
V
A
G
G
--
H
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
T
V
V
F
K
P
S
E
L
T
P
G
V
A
E
L
T
V
R
L
W
E
K
A
G
L
P
D
G
V
I
N
L
V
Q
G
-
G
S
D
T
G
K
C
L
A
R
H
S
L
I
D
G
L
F
F
T
G
S
S
T
V
G
H
L
L
H
E
Q
F
G
G
Q
P
E
K
I
L
A
L
E
M
G
G
N
N
P
L
I
V
Q
N
V
S
D
L
D
G
A
V
H
H
A
L
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
K
G
K
K
G
D
E
F
L
A
R
L
V
E
V
A
A
R
I
T
V
A
E
F
D
A
D
P
Q
P
F
M
G
S
V
I
S
A
E
A
A
N
Q
L
L
K
A
Q
A
A
M
L
E
K
G
A
T
S
L
L
E
M
K
Q
---
L
K
P
D
T
G
L
-----
L
S
P
G
I
-
V
-
D
A
-
T
G
I
E
L
E
D
Q
E
F
F
G
P
L
L
T
V
Y
R
Y
K
G
F
D
E
A
L
E
L
A
N
N
T
R
Y
G
L
S
A
G
I
L
S
D
D
R
K
L
Y
N
R
L
V
E
E
V
R
A
G
I
V
N
W
N
R
P
L
T
G
A
S
S
A
A
P
F
G
G
V
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
W
P
M
A
S
L
E
A
G
K
S
E
L
P
D
S
L
A
P
G
L
N
--
23
PsiBlast_CBE
95.49
58%
-80
- C3 -
-
4KNA
2
ASTD_BURTA
B:
[12-493]
----
L
F
I
D
G
A
W
V
D
G
-
A
G
P
V
F
-
A
S
R
N
P
G
T
N
E
R
V
W
E
G
A
S
A
S
A
D
D
V
E
R
A
V
A
S
A
R
R
A
F
---
A
--
A
W
S
A
L
D
L
D
A
R
C
T
I
V
K
R
F
A
A
L
L
V
E
R
K
E
A
L
A
T
M
I
G
R
E
---
T
G
K
-
P
L
W
E
A
R
-
T
E
V
A
S
M
A
A
K
V
D
I
S
I
T
A
Y
H
E
R
T
G
--
E
K
R
A
P
M
A
D
G
--
V
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
I
A
G
N
T
V
V
F
K
P
S
E
L
A
P
G
V
A
R
A
T
V
E
I
W
R
D
A
G
L
P
A
G
V
L
N
L
V
Q
G
-
E
K
D
T
G
V
A
L
A
N
H
R
Q
I
D
G
L
F
F
T
G
S
S
D
T
G
T
L
L
H
K
Q
F
G
G
R
P
E
I
V
L
A
L
E
M
G
G
N
N
P
L
V
V
A
E
V
E
D
I
D
A
A
V
H
H
A
I
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
I
L
V
P
R
G
A
F
G
D
R
F
V
A
R
L
A
D
V
A
S
K
I
T
A
S
V
F
D
A
D
P
Q
P
F
M
G
A
V
I
S
A
R
A
A
S
R
L
V
A
A
Q
A
R
L
V
G
L
G
A
S
P
I
I
E
M
K
Q
---
R
D
P
A
L
G
F
-----
V
N
A
A
I
-
L
-
D
V
T
N
V
R
E
L
P
D
E
E
H
F
G
P
L
A
Q
I
V
R
Y
T
D
L
D
D
A
I
A
R
A
N
D
T
A
F
G
L
S
A
G
L
L
A
D
D
E
Q
A
W
H
T
F
R
R
A
I
R
A
G
I
V
N
W
N
R
P
T
N
G
A
S
S
A
A
P
F
G
G
A
G
R
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
Y
P
M
A
S
V
E
S
A
Q
L
Q
M
P
A
S
L
S
P
G
L
---
22
PsiBlast_CBE
95.39
59%
-76
- C3 -
-
5U0L
5
ASTD_MARHV
B:
[10-494]
L
T
G
N
V
Y
I
D
G
L
W
L
P
G
-
H
G
A
P
F
-
E
S
V
Q
P
V
T
G
E
T
V
W
D
G
N
A
A
S
L
E
D
V
D
A
A
V
R
E
A
R
K
A
F
---
L
--
A
W
R
R
K
S
L
A
E
R
Q
A
V
I
E
A
F
G
E
L
L
E
A
N
K
E
E
L
A
H
Q
I
G
L
E
---
T
G
K
-
P
L
W
E
S
R
-
T
E
V
A
A
M
M
G
K
I
P
I
S
V
K
A
Y
N
E
R
T
G
--
H
T
E
S
D
V
A
G
G
--
H
A
V
L
R
H
R
P
H
G
V
V
A
V
F
G
P
Y
N
F
P
G
H
L
P
N
G
H
I
V
P
A
L
L
A
G
N
T
V
V
F
K
P
S
E
L
T
P
G
V
A
E
L
T
V
R
L
W
E
K
A
G
L
P
D
G
V
I
N
L
V
Q
G
-
G
S
D
T
G
K
C
L
A
R
H
S
L
I
D
G
L
F
F
T
G
S
S
T
V
G
H
L
L
H
E
Q
F
G
G
Q
P
E
K
I
L
A
L
E
M
G
G
N
N
P
L
I
V
Q
N
V
S
D
L
D
G
A
V
H
H
A
L
Q
S
A
F
L
S
A
G
Q
R
C
T
C
A
R
R
L
L
V
P
K
G
K
K
G
D
E
F
L
A
R
L
V
E
V
A
A
R
I
T
V
A
E
F
D
A
D
P
Q
P
F
M
G
S
V
I
S
A
E
A
A
N
Q
L
L
K
A
Q
A
A
M
L
E
K
G
A
T
S
L
L
E
M
K
Q
---
L
K
P
D
T
G
L
-----
L
S
P
G
I
-
V
-
D
A
T
G
I
E
-
L
E
D
Q
E
F
F
G
P
L
L
T
V
Y
R
Y
K
G
F
D
E
A
L
E
L
A
N
N
T
R
Y
G
L
S
A
G
I
L
S
D
D
R
K
L
Y
N
R
L
V
E
E
V
R
A
G
I
V
N
W
N
R
P
L
T
G
A
S
S
A
A
P
F
G
G
V
G
A
S
G
N
H
R
P
S
---
A
Y
Y
A
-
A
-
D
Y
C
A
W
P
M
A
S
L
E
A
G
K
S
E
L
P
D
S
L
A
P
G
L
---
28
PsiBlast_CBE
68.98
31%
5
- C3 -
-
4PZ2
7
?
C:
[51-534]
--
T
K
L
F
I
N
G
S
F
V
D
A
V
S
G
R
T
F
-
D
T
R
D
P
R
T
G
G
V
I
A
S
V
A
E
A
D
K
E
D
V
D
L
A
V
R
A
A
R
A
A
F
---
D
HG
E
W
P
R
M
S
G
S
E
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
L
E
S
L
D
---
A
G
K
H
P
A
V
T
R
A
-
V
D
V
G
N
A
A
G
S
L
R
Y
F
A
G
A
A
D
K
I
H
G
--
E
T
L
K
M
P
G
Q
F
--
Q
G
H
T
L
R
E
P
L
G
V
A
G
V
I
I
P
W
N
F
P
S
T
M
F
A
V
K
V
A
P
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
A
K
Q
A
G
V
P
D
G
V
I
N
V
V
P
G
F
G
P
T
A
G
A
A
L
A
S
H
M
D
V
D
M
V
S
F
T
G
S
T
E
V
G
R
L
I
M
K
A
S
A
E
S
N
L
K
P
V
Y
L
E
L
G
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
F
N
K
G
E
A
C
V
A
A
S
R
V
Y
V
Q
E
R
V
Y
-
D
R
F
E
E
R
L
A
E
R
M
R
S
W
V
V
G
D
P
F
S
D
P
R
A
D
Q
G
P
Q
V
D
K
A
Q
Y
E
R
V
L
S
Y
I
D
H
G
K
R
E
G
A
-
T
L
L
T
G
G
R
P
C
A
P
--
K
G
Y
Y
-----
I
E
P
T
V
-
F
T
N
V
K
E
D
M
I
I
A
K
E
E
I
F
G
P
V
M
C
L
M
K
F
K
T
V
E
E
A
I
A
R
A
N
D
T
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
R
S
V
R
A
G
V
V
-
W
V
N
C
Y
F
A
M
G
S
D
C
P
F
G
G
R
K
M
S
G
F
G
K
D
E
---
G
M
H
A
-
L
-
D
------
K
Y
L
A
V
K
S
V
V
T
P
L
R
A
S
P
W
I
---
12
PsiBlast_PDB
68.49
31%
6
- C3 -
-
4PZ2
5
?
A:
[51-534]
--
T
K
L
F
I
N
G
S
F
V
D
A
V
S
G
R
T
F
-
D
T
R
D
P
R
T
G
G
V
I
A
S
V
A
E
A
D
K
E
D
V
D
L
A
V
R
A
A
R
A
A
F
---
D
HG
E
W
P
R
M
S
G
S
E
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
L
E
S
L
D
---
A
G
K
H
P
A
V
T
R
A
-
V
D
V
G
N
A
A
G
S
L
R
Y
F
A
G
A
A
D
K
I
H
G
--
E
T
L
K
M
P
G
Q
F
--
Q
G
H
T
L
R
E
P
L
G
V
A
G
V
I
I
P
W
N
F
P
S
T
M
F
A
V
K
V
A
P
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
A
K
Q
A
G
V
P
D
G
V
I
N
V
V
P
G
F
G
P
T
A
G
A
A
L
A
S
H
M
D
V
D
M
V
S
F
T
G
S
T
E
V
G
R
L
I
M
K
A
S
A
E
S
N
L
K
P
V
Y
L
E
L
G
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
F
N
K
G
E
A
C
V
A
A
S
R
V
Y
V
Q
E
R
V
Y
-
D
R
F
E
E
R
L
A
E
R
M
R
S
W
V
V
G
D
P
F
S
D
P
R
A
D
Q
G
P
Q
V
D
K
A
Q
Y
E
R
V
L
S
Y
I
D
H
G
K
R
E
G
A
-
T
L
L
T
G
G
R
P
C
A
P
--
K
G
Y
Y
-----
I
E
P
T
V
-
F
T
N
V
K
E
D
M
I
I
A
K
E
E
I
F
G
P
V
M
C
L
M
K
F
K
T
V
E
E
A
I
A
R
A
N
D
T
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
R
S
V
R
A
G
V
V
-
W
V
N
C
Y
F
A
M
G
S
D
C
P
F
G
G
R
K
M
S
G
F
G
K
D
E
---
G
M
H
A
-
L
-
D
------
K
Y
L
A
V
K
S
V
V
T
P
L
R
A
S
P
W
I
---
27
PsiBlast_CBE
68.12
31%
5
- C3 -
-
4PZ2
3
?
D:
[51-534]
--
T
K
L
F
I
N
G
S
F
V
D
A
V
S
G
R
T
F
-
D
T
R
D
P
R
T
G
G
V
I
A
S
V
A
E
A
D
K
E
D
V
D
L
A
V
R
A
A
R
A
A
F
---
D
HG
E
W
P
R
M
S
G
S
E
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
L
E
S
L
D
---
A
G
K
H
P
A
V
T
R
A
-
V
D
V
G
N
A
A
G
S
L
R
Y
F
A
G
A
A
D
K
I
H
G
--
E
T
L
K
M
P
G
Q
F
--
Q
G
H
T
L
R
E
P
L
G
V
A
G
V
I
I
P
W
N
F
P
S
T
M
F
A
V
K
V
A
P
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
A
K
Q
A
G
V
P
D
G
V
I
N
V
V
P
G
F
G
P
T
A
G
A
A
L
A
S
H
M
D
V
D
M
V
S
F
T
G
S
T
E
V
G
R
L
I
M
K
A
S
A
E
S
N
L
K
P
V
Y
L
E
L
G
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
F
N
K
G
E
A
C
V
A
A
S
R
V
Y
V
Q
E
R
V
Y
-
D
R
F
E
E
R
L
A
E
R
M
R
S
W
V
V
G
D
P
F
S
D
P
R
A
D
Q
G
P
Q
V
D
K
A
Q
Y
E
R
V
L
S
Y
I
D
H
G
K
R
E
G
A
-
T
L
L
T
G
G
R
PCA
P
---
G
Y
Y
-----
I
E
P
T
V
-
F
T
N
V
K
E
D
M
I
I
A
K
E
E
I
F
G
P
V
M
C
L
M
K
F
K
T
V
E
E
A
I
A
R
A
N
D
T
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
R
S
V
R
A
G
V
V
-
W
V
N
C
Y
F
A
M
G
S
D
C
P
F
G
G
R
K
M
S
G
F
G
K
D
E
---
G
M
H
A
-
L
-
D
------
K
Y
L
A
V
K
S
V
V
T
P
L
R
A
S
P
W
I
---
29
PsiBlast_CBE
67.40
31%
8
- C3 -
-
4PZ2
1
?
B:
[51-534]
--
T
K
L
F
I
N
G
S
F
V
D
A
V
S
G
R
T
F
-
D
T
R
D
P
R
T
G
G
V
I
A
S
V
A
E
A
D
K
E
D
V
D
L
A
V
R
A
A
R
A
A
F
---
D
HG
E
W
P
R
M
S
G
S
E
R
G
R
I
M
A
R
L
A
D
L
V
E
E
H
A
G
E
L
A
A
L
E
S
L
D
---
A
G
K
H
P
A
V
T
R
A
-
V
D
V
G
N
A
A
G
S
L
R
Y
F
A
G
A
A
D
K
I
H
G
--
E
T
L
K
M
P
G
Q
F
--
Q
G
H
T
L
R
E
P
L
G
V
A
G
V
I
I
P
W
N
F
P
S
T
M
F
A
V
K
V
A
P
A
L
A
A
G
C
A
L
V
V
K
P
A
E
Q
T
P
L
S
A
L
Y
L
A
Q
L
A
K
Q
A
G
V
P
D
G
V
I
N
V
V
P
G
F
G
P
T
A
G
A
A
L
A
S
H
M
D
V
D
M
V
S
F
T
G
S
T
E
V
G
R
L
I
M
K
A
S
A
E
S
N
L
K
P
V
Y
L
E
L
G
G
K
S
P
L
I
V
F
D
D
A
D
L
D
M
A
V
E
L
A
V
G
A
S
F
F
N
K
G
E
A
C
V
A
A
S
R
V
Y
V
Q
E
R
V
Y
-
D
R
F
E
E
R
L
A
E
R
M
R
S
W
V
V
G
D
P
F
S
D
P
R
A
D
Q
G
P
Q
V
D
K
A
Q
Y
E
R
V
L
S
Y
I
D
H
G
K
R
E
G
A
-
T
L
L
T
G
G
R
P
C
A
P
E
G
K
G
Y
Y
-----
I
E
P
T
V
-
F
T
N
V
K
E
D
M
I
I
A
K
E
E
I
F
G
P
V
M
C
L
M
K
F
K
T
V
E
E
A
I
A
R
A
N
D
T
R
Y
G
L
G
A
G
V
V
T
R
D
L
D
V
A
N
R
V
V
R
S
V
R
A
G
V
V
-
W
V
N
C
Y
F
A
M
G
S
D
C
P
F
G
G
R
K
M
S
G
F
G
K
D
E
---
G
M
H
A
-
L
-
D
------
K
Y
L
A
V
K
S
V
V
T
P
L
R
A
S
P
W
I
---
19
PsiBlast_PDB
67.32
28%
5
- C3 -
-
4NMJ
1
?
A:
[7-491]
M
K
V
A
N
Y
I
N
G
E
F
K
E
P
-
S
T
G
A
F
Q
V
K
T
S
P
V
D
G
S
K
I
A
E
V
P
R
S
G
R
E
D
A
R
E
A
I
D
S
A
F
E
A
L
---
K
--
A
W
A
N
I
P
A
I
R
R
A
E
Y
L
Y
K
M
L
E
V
F
R
Q
M
K
E
D
F
M
K
I
L
T
V
E
GGG
T
Y
R
-
K
V
W
G
E
V
-
V
F
T
E
R
L
I
Q
N
A
A
E
L
A
R
H
Y
Q
G
R
V
L
--
Q
S
D
S
E
S
T
----
I
S
V
V
F
K
R
S
K
G
V
V
G
V
I
T
P
W
N
Y
P
L
S
I
S
M
K
K
I
A
H
T
L
A
V
G
N
T
V
V
Y
K
P
A
S
D
T
P
V
T
G
W
L
I
A
Q
M
V
A
K
A
G
L
P
K
G
V
F
N
L
V
I
G
P
G
P
V
V
G
E
E
I
V
T
H
K
R
V
A
H
V
T
F
T
G
E
S
S
T
G
R
E
I
A
A
K
A
A
G
T
L
-
K
T
V
T
L
E
L
G
G
S
D
P
L
I
I
L
D
D
V
D
V
D
Y
A
A
R
L
A
V
F
A
S
L
F
H
Q
G
Q
I
C
T
S
A
K
R
I
I
V
-
H
K
A
V
A
D
K
F
I
E
R
Y
V
H
Y
V
K
M
L
R
I
D
D
P
R
K
D
E
K
V
D
L
G
P
L
I
N
E
R
Q
V
A
L
M
K
E
F
V
D
D
A
V
S
R
G
G
R
L
L
I
G
------
G
R
S
W
G
N
F
-----
F
E
P
A
I
F
V
-
D
V
D
R
N
F
R
I
M
R
E
E
V
F
G
P
V
R
P
I
V
V
V
E
N
D
D
Q
A
V
E
V
A
N
D
T
D
Y
G
L
S
G
A
V
L
T
N
N
V
N
R
A
F
R
I
A
E
A
V
E
S
G
M
F
H
I
N
D
V
T
F
L
E
E
S
H
V
P
F
G
G
I
K
A
S
G
V
G
R
E
G
G
E
W
S
F
H
E
-
T
-
T
Y
D
R
W
V
T
V
T
L
R
T
R
R
F
P
I
P
S
A
L
K
------
20
PsiBlast_PDB
67.25
28%
8
- C3 -
-
4NMK
1
?
A:
[7-491]
M
K
V
A
N
Y
I
N
G
E
F
K
E
P
-
S
T
G
A
F
Q
V
K
T
S
P
V
D
G
S
K
I
A
E
V
P
R
S
G
R
E
D
A
R
E
A
I
D
S
A
F
E
A
L
---
K
--
A
W
A
N
I
P
A
I
R
R
A
E
Y
L
Y
K
M
L
E
V
F
R
Q
M
K
E
D
F
M
K
I
L
T
V
E
GGG
T
Y
R
-
K
V
W
G
E
V
-
V
F
T
E
R
L
I
Q
N
A
A
E
L
A
R
H
Y
Q
G
R
V
L
--
Q
S
D
S
E
S
T
----
I
S
V
V
F
K
R
S
K
G
V
V
G
V
I
T
P
W
N
Y
P
L
S
I
S
M
K
K
I
A
H
T
L
A
V
G
N
T
V
V
Y
K
P
A
S
D
T
P
V
T
G
W
L
I
A
Q
M
V
A
K
A
G
L
P
K
G
V
F
N
L
V
I
G
P
G
P
V
V
G
E
E
I
V
T
H
K
R
V
A
H
V
T
F
T
G
E
S
S
T
G
R
E
I
A
A
K
A
A
G
T
L
-
K
T
V
T
L
E
L
G
G
S
D
P
L
I
I
L
D
D
V
D
V
D
Y
A
A
R
L
A
V
F
A
S
L
F
H
Q
G
Q
I
C
T
S
A
K
R
I
I
V
-
H
K
A
V
A
D
K
F
I
E
R
Y
V
H
Y
V
K
M
L
R
I
D
D
P
R
K
D
E
K
V
D
L
G
P
L
I
N
E
R
Q
V
A
L
M
K
E
F
V
D
D
A
V
S
R
G
G
R
L
L
I
G
------
G
R
S
W
G
N
F
-----
F
E
P
A
I
F
V
-
D
V
D
R
N
F
R
I
M
R
E
E
V
F
G
P
V
R
P
I
V
V
V
E
N
D
D
Q
A
V
E
V
A
N
D
T
D
Y
G
L
S
G
A
V
L
T
N
N
V
N
R
A
F
R
I
A
E
A
V
E
S
G
M
F
H
I
N
D
V
T
F
L
E
E
S
H
V
P
F
G
G
I
K
A
S
G
V
G
R
E
G
G
E
W
S
F
H
E
-
T
-
T
Y
D
R
W
V
T
V
T
L
R
T
R
R
F
P
I
P
S
A
L
K
------
16
PsiBlast_PDB
66.20
30%
25
- C3 -
-
5FHZ
2
AL1A3_HUMAN
A:
[50-514]
---
K
I
F
I
N
N
E
W
H
E
S
K
S
G
K
K
F
-
A
T
C
N
P
S
T
R
E
Q
I
C
E
V
E
E
G
D
K
P
D
V
D
K
A
V
E
A
A
Q
V
A
F
QRG
S
--
P
W
R
R
L
D
A
L
S
R
G
R
L
L
H
Q
L
A
D
L
V
E
R
D
R
A
T
L
A
A
L
E
T
M
D
---
T
G
K
-
P
F
L
H
A
F
F
I
D
L
E
G
C
I
R
T
L
R
Y
F
A
G
W
A
D
K
I
Q
G
--
K
T
I
P
T
D
D
N
V
--
V
C
F
T
R
H
E
P
I
G
V
C
G
A
I
T
P
W
N
F
P
L
L
M
L
V
W
K
L
A
P
A
L
C
C
G
N
T
M
V
L
K
P
A
E
Q
T
P
L
T
A
L
Y
L
G
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
F
G
P
T
V
G
A
A
I
S
S
H
P
Q
I
N
K
I
A
F
T
G
S
T
E
V
G
K
L
V
K
E
A
A
S
R
S
N
L
K
R
V
T
L
E
L
G
G
K
N
P
C
I
V
C
A
D
A
D
L
D
L
A
V
E
C
A
H
Q
G
V
F
F
N
Q
G
Q
C
C
T
A
A
S
R
V
F
V
E
E
Q
V
Y
S
E
-
F
V
R
R
S
V
E
Y
A
K
K
R
P
V
G
D
P
F
D
V
K
T
E
-
Q
G
P
Q
I
D
Q
K
Q
F
D
K
I
L
E
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
S
A
---
M
E
D
K
G
L
F
-----
I
K
P
T
V
-
F
S
E
V
T
D
N
M
R
I
A
K
E
E
I
F
G
P
V
Q
P
I
L
K
F
K
S
I
E
E
V
I
K
R
A
N
S
T
D
Y
G
L
T
A
A
V
F
T
K
N
L
D
K
A
L
K
L
A
S
A
L
E
S
G
T
V
-
W
I
N
C
Y
N
A
L
Y
A
Q
A
P
F
G
G
F
K
M
S
G
N
G
R
E
L
---
G
E
Y
A
L
A
-
E
Y
--------------------------
34
PsiBlast_CBE
65.88
32%
15
- C3 -
-
4GO4
2
?
D:
[1-467]
M
Q
N
Q
L
Y
I
D
G
R
F
V
D
A
V
A
G
G
T
I
-
D
V
V
S
P
H
D
G
S
L
I
T
R
I
A
A
A
E
A
A
D
V
D
L
A
V
A
A
A
K
R
A
F
---
P
--
A
W
S
A
L
G
A
A
E
R
G
R
L
L
L
K
L
A
D
R
I
E
E
C
S
E
E
L
A
Q
L
E
S
L
N
---
T
G
H
-
P
I
R
D
S
R
-
G
---
L
D
V
P
R
T
A
A
C
F
R
Y
F
G
G
M
A
D
KI
E
G
S
V
I
P
V
D
A
GF
L
N
Y
V
Q
R
K
P
I
G
V
V
A
Q
I
V
P
W
N
F
P
L
M
F
T
S
W
K
M
G
P
A
L
A
A
G
N
T
I
V
I
K
P
S
E
I
T
P
L
S
T
L
R
I
V
E
L
M
T
E
V
G
F
P
K
G
V
V
N
V
V
P
G
Y
G
H
T
A
G
Q
A
L
A
E
H
L
D
V
G
K
I
A
F
T
G
S
T
A
T
G
R
R
I
-
V
E
A
S
K
S
N
L
K
R
I
Q
L
E
L
G
G
K
G
A
N
I
V
F
E
D
A
N
I
E
A
A
V
N
G
A
A
W
A
I
F
H
N
Q
G
Q
A
C
I
A
G
S
R
L
I
L
H
K
D
I
-
A
D
Q
F
L
E
R
F
I
A
L
A
K
S
I
R
L
G
D
P
M
D
P
E
T
E
-
M
G
P
L
T
S
A
L
R
R
D
R
V
L
S
Y
I
D
I
A
I
E
Q
G
G
K
V
L
A
G
G
K
A
---
P
-
D
D
K
A
L
ANGFY
V
E
P
T
V
-
V
-
E
A
K
P
Q
D
R
V
C
Q
E
E
V
F
G
P
F
V
T
V
V
R
F
S
S
D
E
E
A
L
A
I
A
N
N
T
E
Y
G
L
G
S
G
L
W
T
Q
N
L
A
R
A
H
K
M
A
H
A
I
H
A
G
M
C
-
W
I
N
C
Y
K
R
V
S
P
G
S
P
F
G
G
V
G
Q
S
G
Y
G
R
E
M
---
G
F
E
A
-
I
H
D
Y
--------------------------