@TOME V2.3
(Mar 2018)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQC0: (2017-11-26 )
MELSMSKTFAEFSLHETLQQALEGLGFTNPTPVQEQSIPAALEGKDLLVSSQTGSGKTAAFLLPTLHNLAGQDTFVPFKERMKAVTQPSILVLCPTRELAQQVSQDAIAFVRHMKGVRIAAIMGGMPFGKQIQQLKGAQVVVATPGRLLDLVNRRQLKLDKVDALIVDEADRMLDLGFSEDLEAISDLAVNRGQTLMFSATFADRIIRLAERMMNEPERIAIETGHSTNTDITQTLHWTDGFEHKKKLLTHWLADETLDQAVVFASTQEDTDMLAEELAEAGHSVVALHGAMPQTARNRRLRSIREGRAKILVATDVAARGLDVPTISHVINFGLPMKHEDYVHRIGRTGRAGRTGQAITLATYRERGKIRALEDYLEARLNVSEIEGLEASPPPARPRREGGRGGNGGRDGRRGGGFGGGRRFEGEGNFKRREGGRDDRPRRSFDDKPRGERPAFGGEDRPRREFNSDRPRREGGFEDRPKRSFGGEDRPRREFNSDRPRREGGFEDRPKRSFGGEDRPRREFNSDRPRREGGFNDKPRFDSNDDNRGNRVDYKPRRENGFGDRPQRSFGGEDRPRREGGFGDRPKRSFGGEDRPRRTVREEHFNQESRGERRRKFDR
Atome Classification :
(54 SA)
.........10........20........30........40..--.--.....50........60........70......---..80--......-.----------..90........100.......110...-----.---...120....-..--.130--..-.--.--...140.......150...-.-.--...160.........170...--.-...180.-.-.----...----.----190------..--..--....200.......210.......220....----...230.......240...----.-...250..-.-....260.......270.......280--........290.......300.......310.......320.......330....------.------..340----.........350.......360....-.-..370........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEL
S
M
S
K
T
F
A
E
F
S
L
H
E
T
L
Q
Q
A
L
E
GLGFTNPTPVQEQSIPAALE--G--
K
D
L
L
V
SSQTGSG
K
T
A
A
F
L
L
P
T
L
H
N
LAGQDTFV
P
---
F
K
E
---
R
M
K
A
VT-Q----------P
S
I
L
V
L
CP
T
R
E
L
A
Q
Q
V
S
Q
D
A
I
A
F
V
R
H
MK-----G---
V
R
I
A
A
I
MGGM-P
F
--
G
K
Q
I
--
Q
Q
-L--K--G
A
Q
V
V
V
ATP
G
R
L
L
D
-
L
V
N
R
-
R
-Q--LKLD--KV
D
A
L
I
VDEA
D
R
M
LD--L-G
F
S
E
D
L
E
-
A
-
I
----
S
D
L
----A----VN-------RG--
Q
T
--
L
M
F
S
A
T
F
A
D
R
I
I
R
L
A
E
R
M
MNEP
E
R
I
A
I
ETGH----STNTD
I
T
Q
T
L
HWTDG
F
E
H
K
----
K
-
K
L
L
T
H
W
L
A
-
D
-
E
T
LD
Q
A
V
V
F
ASTQ
E
D
T
D
M
L
A
E
E
L
A
EA---GH
S
V
V
A
LHGAMP
Q
T
A
R
N
R
R
L
R
S
I
REGR
A
K
I
L
V
A
T
D
V
AARGLD
V
P
T
I
S
H
V
I
NFGLP------M------K
H
E
------
D
Y
V
H
R
IGRTGRAGRTG
Q
A
I
T
L
A
T
Y
R
E-R-GK
I
-
R
A
L
E
D
Y
L
E
ARL
N
V
S
E
IEGLEASPPPARPRREGGRGGNGGRDGRRGGGFGGGRRFEGEGNFKRREGGRDDRPRRSFDDKPRGERPAFGGEDRPRREFNSDRPRREGGFEDRPKRSFGGEDRPRREFNSDRPRREGGFEDRPKRSFGGEDRPRREFNSDRPRREGGFNDKPRFDSNDDNRGNRVDYKPRRENGFGDRPQRSFGGEDRPRREGGFGDRPKRSFGGEDR
P
R
R
T
V
R
E
E
HFNQ
E
S
R
G
E
R
R
RKFDR
38
PsiBlast_CBE
83.50
34%
-145
- C4 -
-
2VSO
1
IF4A_YEAST
A:
[24-383]
--------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---
D
T
---------------
S
V
K
-
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
------
D
---
I
K
V
H
A
C
I
G
----------------
L
--
R
--
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
--
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
--
S
-
G
F
K
E
Q
I
Y
-
Q
-
I
----
F
T
L
----
L
----
P
P
-------
T
T
--
Q
V
--
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
----
Y
-
E
C
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
-
R
E
L
E
K
F
Y
S
T
Q
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
83.17
34%
-145
- C4 -
-
2VSO
1
IF4A_YEAST
B:
[24-383]
--------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---
D
T
---------------
S
V
K
-
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
------
D
---
I
K
V
H
A
C
I
G
----------------
L
--
R
--
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
--
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
--
S
-
G
F
K
E
Q
I
Y
-
Q
-
I
----
F
T
L
----
L
----
P
P
-------
T
T
--
Q
V
--
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
----
Y
-
E
C
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
-
R
E
L
E
K
F
Y
S
T
Q
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
83.09
34%
-142
- C4 -
-
2VSX
1
IF4A_YEAST
A:
[24-383]
--------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---
D
T
---------------
S
V
K
-
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
------
D
---
I
K
V
H
A
C
I
G
----------------
L
--
R
--
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
--
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
--
S
-
G
F
K
E
Q
I
Y
-
Q
-
I
----
F
T
L
----
L
----
P
P
-------
T
T
--
Q
V
--
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
----
Y
-
E
C
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
-
R
E
L
E
K
F
Y
S
T
Q
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
82.88
34%
-141
- C4 -
-
2VSX
1
IF4A_YEAST
B:
[24-383]
--------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
---
D
T
---------------
S
V
K
-
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
------
D
---
I
K
V
H
A
C
I
G
----------------
L
--
R
--
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
--
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
--
S
-
G
F
K
E
Q
I
Y
-
Q
-
I
----
F
T
L
----
L
----
P
P
-------
T
T
--
Q
V
--
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
----
Y
-
E
C
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
-
R
E
L
E
K
F
Y
S
T
Q
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
81.47
35%
-142
- C4 -
-
1FUU
-
IF4A_YEAST
B:
[18-380]
---
K
V
V
Y
K
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
D
T
S
V
------------------
K
-
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
H
M
------
D
---
I
K
V
H
A
C
I
G
G
T
-
S
F
--
V
E
D
A
--
E
G
-
L
--
R
--
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
--
F
R
T
D
--
K
I
K
M
F
I
L
D
E
A
D
E
M
L
S
--
S
-
G
F
K
E
Q
I
Y
-
Q
-
I
----
F
T
L
----
L
----
P
P
-------
T
T
--
Q
V
--
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
----
L
T
L
E
G
I
K
Q
F
Y
V
N
V
E
E
E
E
Y
K
----
Y
-
E
C
L
T
D
L
Y
D
-
S
-
I
S
V
T
Q
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
------
A
------
N
K
E
------
N
Y
I
H
R
I
G
R
G
G
----
K
G
V
A
I
N
F
V
T
N
E
D
-
V
-
G
A
M
-
R
E
L
E
K
F
Y
S
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
79.54
38%
-47
- C4 -
-
2DB3
2
VASA1_DROME
A:
[53-421]
---
Q
P
I
Q
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
H
E
-------------
L
E
L
G
-
R
----------
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
S
------
Y
---
L
K
I
G
I
V
Y
G
G
T
-
S
F
--
R
H
Q
N
--
E
C
-
I
T
-
R
--
G
C
H
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
-
T
-
F
--
I
T
F
E
--
D
T
R
F
V
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
S
E
D
M
R
-
R
-
I
----
M
T
H
----
V
TM--
R
P
-------
E
H
--
Q
T
--
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
----
G
A
C
S
D
V
K
Q
T
I
Y
E
V
N
K
Y
-
A
K
----
R
-
S
K
L
I
E
I
L
S
-
E
--
Q
A
D
G
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
------
S
------
K
I
D
------
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
-
D
R
A
I
A
-
A
D
L
V
K
I
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
78.60
34%
-54
- C4 -
-
4CT4
-
DDX6_HUMAN
B:
[2-367]
---
S
M
G
N
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
L
K
K
------------------
D
-
N
----------
I
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
-----
G
---
A
K
V
M
A
T
T
G
G
T
-
N
L
--
R
D
D
I
--
M
R
-
L
D-
D
--
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
-
G
-
V
--
A
K
V
D
--
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
--
Q
-
D
F
V
Q
I
M
E
-
D
-
I
----
I
L
T
----
L
----
P
K
-------
N
R
--
Q
I
--
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
-----
L
T
L
K
G
V
T
Q
Y
Y
A
Y
V
-
T
E
R
Q
K
----
V
-
H
C
L
N
T
L
F
S
-
R
-
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
-
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
77.61
33%
-47
- C4 -
-
4CT4
-
DDX6_HUMAN
B:
[2-371]
---
S
M
G
N
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
L
K
---------
K
D
---
N
I
Q
A
-----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
-----
G
---
A
K
V
M
A
T
T
G
G
T
-
N
L
--
R
D
D
I
--
M
R
-
L
--
D
D-
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
-
G
-
V
--
A
K
V
D
--
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
--
Q
-
D
F
V
Q
I
M
E
D
I
-
I
----
L
T
L
----
P
----
K
N
-------
R
---
Q
I
--
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
-
M
E
E
----
L
T
L
K
G
V
T
Q
Y
Y
A
Y
V
T
E
-
R
Q
K
----
V
-
H
C
L
N
T
L
F
S
-
R
-
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
-
K
S
I
E
E
Q
L
----------
G
T
E
I
K
P
I
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.19
33%
-51
- C4 -
-
5ANR
-
DDX6_HUMAN
B:
[95-462]
-----
G
N
E
F
E
D
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
D
L
K
---------
K
D
---
N
I
Q
A
-----------------
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
H
M
G
-----
G
---
A
K
V
M
A
T
T
G
G
T
-
N
L
--
R
D
D
I
--
M
R
-
L
--
D
D-
T
V
H
V
V
I
A
T
P
G
R
I
L
D
-
L
I
K
K
-
G
-
V
--
A
K
V
D
--
H
V
Q
M
I
V
L
D
E
A
D
K
L
L
S
--
Q
-
D
F
V
Q
I
M
E
D
I
-
I
----
L
T
L
----
P
----
K
N
-------
R
---
Q
I
--
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
-
M
E
E
----
L
T
L
K
G
V
T
Q
Y
Y
A
Y
V
T
E
-
R
Q
K
----
V
-
H
C
L
N
T
L
F
S
-
R
-
L
Q
I
N
Q
S
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
----
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
------
K
------
L
A
E
------
T
Y
L
H
R
I
G
R
S
G
----
L
G
L
A
I
N
L
I
T
Y
D
D
-
R
-
F
N
L
-
K
S
I
E
E
Q
L
----------
G
T
E
I
K
P
I
P
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
76.86
34%
-42
- C4 -
-
2HYI
2
IF4A3_HUMAN
I:
[33-401]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.77
34%
-47
- C4 -
-
2J0S
2
IF4A3_HUMAN
A:
[32-400]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D
-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
76.73
43%
-42
- C4 -
-
5IVL
-
?
B:
[4-364]
--------
F
Q
E
L
G
L
S
Q
E
V
M
K
A
I
E
R
M
G
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
--
N
--
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
V
K
N
------------------
G
-
A
----------
I
Q
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
K
------
R
---
V
R
V
L
P
I
Y
G
G
Q
-
D
I
--
E
R
Q
I
--
R
A
L
K
--
K
--
H
P
H
V
I
V
G
T
P
G
R
I
I
D
-
H
I
N
R
-
G
-
T
--
L
R
L
E
--
H
V
H
T
V
V
L
D
E
A
D
E
M
L
-----
G
F
I
E
D
I
E
-
A
-
I
----
L
S
H
----
V
----
P
A
-------
E
R
--
Q
T
--
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
R
F
M
N
E
P
E
L
V
K
V
K
A
--------
V
P
N
I
Q
Q
Y
Y
L
E
V
H
-
E
K
K
K
----
F
-
D
I
L
T
R
L
L
D
-
I
-
Q
A
P
E
L
A
I
V
F
G
R
T
K
R
R
V
D
E
L
A
E
A
L
N
L
R
---
G
Y
A
A
E
G
I
H
G
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
F
D
I
P
------
Q
------
D
P
E
------
S
Y
V
H
R
I
G
R
T
G
R
A
G
K
T
G
V
A
M
T
F
V
T
P
R
E
-
I
-
G
Q
L
-
H
H
I
E
R
T
T
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.58
34%
-46
- C4 -
-
2J0Q
2
IF4A3_HUMAN
A:
[32-400]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D
-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
76.47
34%
-45
- C4 -
-
2XB2
1
IF4A3_HUMAN
X:
[33-401]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
76.30
34%
-43
- C4 -
-
2XB2
1
IF4A3_HUMAN
A:
[33-401]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D
-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
76.22
34%
-46
- C4 -
-
2J0Q
2
IF4A3_HUMAN
B:
[32-400]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
76.22
34%
-44
- C4 -
-
2HYI
2
IF4A3_HUMAN
C:
[33-401]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D
-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
76.00
42%
-31
- C4 -
-
4KBF
1
?
A:
[3-354]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L
-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
----
P
V
T
Y
E
E
E
A
V
P
A
P
V
R
G
---
R
----
L
-
E
V
L
S
D
L
L
Y
-
V
-
A
S
P
D
R
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
------
D
------
R
A
E
------
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
E
-
R
-
R
D
V
-
E
A
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
HHSearch
75.91
39%
-21
- C4 -
-
2I4I
1
DDX3X_HUMAN
A:
[12-397]
---
P
H
I
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
E
A
L
R
A
M
K
E
NGR
Y
G
R
R
K
Q
-
Y
----------
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
S
------
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
----
V
E
Q
----
D
TMPP
K
G
-------
V
R
--
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
--------
T
S
E
N
I
T
Q
K
V
V
W
V
E
-
E
S
D
K
----
R
-
S
F
L
L
D
L
L
N
-
A
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
-
K
D
L
L
D
L
L
V
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
75.91
34%
-42
- C4 -
-
3EX7
3
IF4A3_HUMAN
H:
[33-401]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.91
34%
-47
- C4 -
-
3EX7
3
IF4A3_HUMAN
C:
[33-401]
-
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
D
I
Q
------------------
V
R
-
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
M
------
N
---
V
Q
C
H
A
C
I
G
G
T
-
N
V
--
G
E
D
I
--
R
K
-
L
D
-
Y
--
G
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
--
L
R
T
R
--
A
I
K
M
L
V
L
D
E
A
D
E
M
L
N
--
K
-
G
F
K
E
Q
I
Y
-
D
-
V
----
Y
R
Y
----
L
----
P
P
-------
A
T
--
Q
V
--
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
E
----
L
T
L
E
G
I
K
Q
F
F
V
A
V
E
R
E
E
W
K
----
F
-
D
T
L
C
D
L
Y
D
-
T
-
L
T
I
T
Q
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
------
N
------
N
R
E
------
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
D
-
I
-
R
I
L
-
R
D
I
E
Q
Y
Y
S
T
Q
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.26
38%
-19
- C4 -
-
2I4I
1
DDX3X_HUMAN
A:
[15-395]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
-
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
V
E--
Q
D
T
----
M
----
P
P
-------
K
G
V
R
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
--------
T
S
E
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
R
----
S
-
F
L
L
D
L
L
N
A
-
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
-
K
D
L
L
D
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.16
38%
-10
- C4 -
-
5E7J
1
DDX3X_HUMAN
A:
[48-428]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
--KQY-------
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
V
E--
Q
D
T
----
M
----
P
P
-------
K
G
V
R
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
----
S
T
S
E
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
R
----
S
-
F
L
L
D
L
L
N
A
-
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
-
K
D
L
L
D
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.56
38%
-10
- C4 -
-
4PXA
1
DDX3X_HUMAN
A:
[65-445]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
-
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
V
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
V
E--
Q
D
T
----
M
----
P
P
-------
K
G
V
R
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
----
S
T
S
E
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
R
----
S
-
F
L
L
D
L
L
N
A
-
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
-
K
D
L
L
D
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
72.32
34%
-9
- C4 -
-
4D25
3
?
A:
[48-421]
----
P
I
E
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
K
D
L
I
---------
S
E
N
G
C
A
-
Q
----------
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
------
V
---
L
K
V
A
V
A
Y
G
G
T
-
A
V
--
R
H
Q
G
--
D
N
-
I
A
-
R
--
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
--
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
--
M
-
G
F
M
P
S
I
E
-
K
-
M
----
M
L
H
PTMV
E
----
T
T
-------
K
R
--
Q
T
--
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
----
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
-
K
Y
E
K
----
R
-
N
S
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
-
D
L
A
L
V
-
A
D
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
HHSearch
71.42
32%
-17
- C4 -
-
3G0H
3
DD19B_HUMAN
A:
[37-413]
--
L
Y
S
V
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
P
A
N
------------------
K
-
Y
----------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-----
E
---
L
K
L
A
Y
A
V
R
G
N
-
K
L
--
E
R
----
G
Q
-
K
--
I
--
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
-
F
--
I
D
P
K
--
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T-
Q
-
G
H
Q
D
Q
S
I
-
R
-
I
----
Q
R
M
----
L
----
P
R
-------
N
C
--
Q
M
--
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
E
K
----
F
-
Q
A
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
VDKDGN
P
------
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
M
-
N
I
L
-
N
R
I
Q
E
H
F
N
K
K
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
71.42
34%
-15
- C4 -
-
4D26
2
?
A:
[48-421]
----
P
I
E
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
K
D
L
I
---------
S
E
N
G
C
A
-
Q
----------
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
S
------
V
---
L
K
V
A
V
A
Y
G
G
T
-
A
V
--
R
H
Q
G
--
D
N
-
I
A
-
R
--
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
--
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
--
M
-
G
F
M
P
S
I
E
-
K
-
M
----
M
L
H
PTMV
E
----
T
T
-------
K
R
--
Q
T
--
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
----
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
-
K
Y
E
K
----
R
-
N
S
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
Q
-
D
L
A
L
V
-
A
D
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
71.41
32%
-34
- C4 -
-
1XTI
4
DX39B_HUMAN
A:
[9-377]
-------
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
----------------
Q
---
Q
L
E
P
V
T
G
Q
----------
V
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
M
P
-----
N
---
V
K
V
A
V
F
F
G
G
L
-
S
I
--
K
K
D
E
--
E
V
-
L
--
K
KN
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
-
K
-
S
--
L
N
L
K
--
H
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q-
L
-
D
M
R
R
D
V
Q
-
E
-
I
----
F
R
M
----
T
----
P
H
-------
E
K
--
Q
V
--
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
----
K
L
T
L
H
G
L
Q
Q
Y
Y
V
K
L
K
D
N
E
K
----
N
-
R
K
L
F
D
L
L
D
-
V
-
L
E
F
N
Q
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
---
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
------
E
------
D
S
D
------
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
E
N
-
D
-
A
K
I
L
N
D
V
Q
D
R
F
E
--
V
N
I
S
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
70.25
38%
10
- C4 -
-
5E7M
1
DDX3X_HUMAN
A:
[48-428]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
--R
R
K
Q
Y
-----
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
V
E--
Q
D
T
----
M
----
P
P
-------
K
G
V
R
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
----
S
T
S
E
N
I
T
Q
K
V
V
W
V
E
E
S
D
K
R
----
S
-
F
L
L
D
L
L
N
A
-
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
------
S
------
D
I
E
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
R
N
-
I
-
N
I
T
-
K
D
L
L
D
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
HHSearch
69.03
33%
-11
- C4 -
-
3PEY
3
DBP5_YEAST
A:
[4-359]
-----
A
K
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
E
D
------------------
A
-
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
------
K
---
I
T
S
Q
L
I
V
P
D
S
-
F
----
E
-
K
--
N
K
-
Q
--
I
--
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
--
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
G
L
G
D
Q
C
I
-
R
-
V
----
K
R
F
----
L
----
P
K
-------
D
T
--
Q
L
--
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
----
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
K
----
F
-
D
V
L
T
E
L
Y
G
-
L
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
LANGQA
D
P
A
------
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
-
S
-
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
68.11
32%
-18
- C4 -
-
3PEY
3
DBP5_YEAST
A:
[4-353]
-----
A
K
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
E
D
A
-------------------
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
-----
I
---
T
S
Q
L
I
V
P
D
S
F
-
E
K
--
N
K
Q
I
-----------
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
--
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
G
L
G
D
Q
C
I
-
R
-
V
----
K
R
F
----
L
----
P
K
-------
D
T
--
Q
L
--
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
-
N
----
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
----
K
F
D
V
L
T
E
L
Y
G
-
L
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
67.96
32%
-20
- C4 -
-
3PEW
2
DBP5_YEAST
A:
[4-353]
-----
A
K
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
E
D
A
-------------------
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
-----
I
---
T
S
Q
L
I
V
P
D
S
F
-
E
K
--
N
K
Q
I
-----------
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
--
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
G
L
G
D
Q
C
I
-
R
-
V
----
K
R
F
----
L
----
P
K
-------
D
T
--
Q
L
--
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
-
N
----
E
V
N
V
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
----
K
F
D
V
L
T
E
L
Y
G
-
V
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
67.43
32%
-19
- C4 -
-
3RRN
2
DBP5_YEAST
A:
[2-353]
---
A
M
A
K
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
E
D
A
-------------------
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
T
K
-----
I
---
T
S
Q
L
I
V
P
D
S
F
-
E
K
--
N
K
Q
I
-----------
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
--
M
Q
L
Q
--
K
I
K
I
F
V
L
D
E
A
D
N
M
L
D
--
Q
Q
G
L
G
D
Q
C
I
-
R
-
V
----
K
R
F
----
L
----
P
K
-------
D
T
--
Q
L
--
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
-----------
D
A
I
K
Q
L
Y
M
D
C
K
N
E
A
D
----
K
F
D
V
L
T
E
L
Y
G
-
V
-
M
T
I
G
S
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
------
T
------
L
A
N
GQAD
P
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
67.28
31%
-10
- C4 -
-
3FHT
3
DD19B_HUMAN
A:
[21-384]
--
L
Y
S
V
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
P
A
N
K
Y
-----------------------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-----
E
---
L
K
L
A
Y
A
V
R
G
N
-
K
L
E
R
G
Q
K
I
--
S
E
---------
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
-
L
-
K
--
F
-
I
D
PK
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
--
T
-
Q
G
H
Q
D
Q
S
-
I
R
I
----
Q
R
M
----
L
----
P
R
-------
N
C
--
Q
M
--
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
E
K
----
F
-
Q
A
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
-
M
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
66.95
36%
-7
- C4 -
-
4D25
3
?
A:
[69-404]
-------------------------
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
-
N
M
L
L
Q
D
P
K
D
L
---
I
S
E
-----
N
G
C
A
-
Q
----------
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
-
S
Y
G
S
-----
V
---
L
K
V
A
V
A
Y
G
G
T
-
A
V
--
R
H
Q
G
--
D
N
-
I
A
-
R
--
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
--
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
--
M
-
G
F
M
P
S
I
E
-
K
-
M
M
L
HP
T
M
V
----
E
----
T
T
-------
K
R
--
Q
T
--
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
----
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
K
Y
E
-
K
----
R
-
N
S
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
66.93
36%
-13
- C4 -
-
4D26
2
?
A:
[69-404]
-------------------------
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
-
N
M
L
L
Q
D
P
K
D
L
---
I
S
E
-----
N
G
C
A
-
Q
----------
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
-
S
Y
G
S
-----
V
---
L
K
V
A
V
A
Y
G
G
T
-
A
V
--
R
H
Q
G
--
D
N
-
I
A
-
R
--
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
--
V
S
F
G
--
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
D
--
M
-
G
F
M
P
S
I
E
-
K
-
M
M
L
HP
T
M
V
----
E
----
T
T
-------
K
R
--
Q
T
--
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
----
G
A
S
T
D
V
E
Q
I
F
I
E
V
T
K
Y
E
-
K
----
R
-
N
S
L
K
Q
L
I
E
-
E
-
N
D
G
K
R
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
------
K
------
S
I
D
------
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
66.34
31%
-8
- C4 -
-
3G0H
3
DD19B_HUMAN
A:
[37-400]
--
L
Y
S
V
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
P
A
N
K
Y
-----------------------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-----
E
---
L
K
L
A
Y
A
V
R
G
N
-
K
L
ER
G
Q
K
I
--
S
E
---------
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
-
L
-
K
--
F
-
I
D
PK
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
--
T
-
Q
G
H
Q
D
Q
S
-
I
R
I
----
Q
R
M
----
L
----
P
R
-------
N
C
--
Q
M
--
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
E
K
----
F
-
Q
A
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
-
M
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
64.87
31%
13
* C4 *
-
3FHT
5
DD19B_HUMAN
B:
[21-384]
--
L
Y
S
V
K
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
P
A
N
K
Y
-----------------------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-----
E
---
L
K
L
A
Y
A
V
R
G
N
-------
K
I
--
S
E
---------
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
-
L
-
K
--
F
-
I
D
PK
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
--
T
-
Q
G
H
Q
D
Q
S
-
I
R
I
----
Q
R
M
----
L
----
P
R
-------
N
C
--
Q
M
--
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
----
E
T
L
D
T
I
K
Q
Y
Y
V
L
C
S
S
R
D
E
K
----
F
-
Q
A
L
C
N
L
Y
G
-
A
-
I
T
I
A
Q
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
------
V
DKDGNP
D
N
E
------
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
-
S
-
M
N
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
64.76
30%
5
- C4 -
-
3I5X
2
MS116_YEAST
A:
[74-458]
--------
L
E
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
K
F
--------------
D
S
Q
Y
-
M
----------
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
-----
G
LKK
Y
A
C
V
S
L
V
G
G
T
-
D
F
--
R
A
A
M
--
N
K
-
M
N
K
L
--
R
P
N
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
-
Y
S
N
--
K
F
F
R
--
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
--
I
-
G
F
R
D
D
L
E
-
T
-
I
----
S
G
I
----
L
----
N
E
K
NSKSAD
N
I
--
K
T
--
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
KNEP
E
A
H
E
R
I
D
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
K
K
Q
I
K
-
E
R
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
-
R
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
64.55
30%
2
- C4 -
-
3SQW
2
MS116_YEAST
A:
[27-406]
------------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
K
F
--------------
D
S
Q
Y
-
M
----------
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
M
N
Y
GLK--
K
---
Y
A
C
V
S
L
V
G
G
T
-
D
F
--
R
A
A
M
--
N
K
-
M
N
K
L
--
R
P
N
I
V
I
A
T
P
G
R
L
I
D
-
V
L
E
K
-
Y
S
N
--
K
F
F
R
--
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
E
--
I
-
G
F
R
D
D
L
E
-
T
-
I
----
S
G
I
----
L
----
N
E
K
NSKSAD
N
I
--
K
T
--
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
D
KNEP
E
A
H
E
R
I
D
Q
S
V
V
I
S
E
K
F
A
N
S
I
F
A
A
V
-
E
H
I
K
K
Q
I
K
E
R
-
D
S
N
Y
K
A
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
------
S
------
E
L
A
------
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
E
-
L
-
P
F
V
-
R
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
58.00
44%
-68
- C4 -
-
2GXQ
2
?
A:
[3-205]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L
-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
57.92
45%
-79
- C4 -
-
5GJU
1
?
A:
[2-205]
-------
T
F
A
D
L
G
L
K
A
P
I
L
E
A
L
N
D
L
G
Y
E
K
P
S
P
I
Q
A
E
C
I
P
H
L
L
N
--
G
--
R
D
V
L
G
M
A
Q
T
G
S
G
K
T
A
A
F
S
L
P
L
L
Q
N
L
------------
D
P
---
E
L
K
A
--------------
P
Q
I
L
V
L
A
P
T
R
E
L
A
V
Q
V
A
E
A
M
T
D
F
S
K
H
M
R
-----
G
---
V
N
V
V
A
L
Y
---------
V
Q
L
--
R
A
-
L
R
-
Q
--
G
P
Q
I
V
V
G
T
P
G
R
L
L
D
-
H
L
K
R
-
G
-
T
--
L
D
L
S
--
K
L
S
G
L
V
L
D
E
A
D
E
M
L
R
--
M
-
G
F
I
E
D
V
E
-
T
-
I
----
M
A
Q
----
I
----
P
E
-------
G
H
--
Q
T
--
A
L
F
S
A
T
M
P
E
A
I
R
R
I
T
R
R
F
M
K
E
P
Q
E
V
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
56.82
44%
-70
- C4 -
-
3MWL
1
?
B:
[3-205]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
56.73
44%
-67
- C4 -
-
2GXS
2
?
B:
[3-205]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
56.43
44%
-59
- C4 -
-
3NBF
2
?
A:
[3-205]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L
-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
56.03
44%
-72
- C4 -
-
3MWK
1
?
B:
[3-205]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
55.31
35%
-57
- C4 -
-
5GVR
1
DDX41_HUMAN
A:
[13-230]
------
K
S
F
K
E
M
K
F
P
A
A
I
L
R
G
L
K
K
K
G
I
H
H
P
T
P
I
Q
I
Q
G
I
P
T
I
L
S
--
G
--
R
D
M
I
G
I
A
F
T
G
S
G
K
T
L
V
F
T
L
P
V
I
M
F
C
L
E
Q
E
K
R
L
P
---
F
S
K
---
R
----
E
-
G
----------
P
Y
G
L
I
I
C
P
S
R
E
L
A
R
Q
T
H
G
I
L
E
Y
Y
C
R
L
L
Q
E
D
SS
P
L
---
L
R
C
A
L
C
I
G
G
M
-
S
V
--
K
E
Q
M
--
E
T
-
I
--
R
H
-
G
V
H
M
M
V
A
T
P
G
R
L
M
D
-
L
L
Q
K
-
K
-
M
--
V
S
L
D
--
I
C
R
Y
L
A
L
D
E
A
D
R
M
I
D
--
M
-
G
F
E
G
D
I
R
-
T
-
I
----
F
S
Y
----
F
----
K
G
-------
Q
R
--
Q
T
--
L
L
F
S
A
T
M
P
K
K
I
Q
N
F
A
K
S
A
L
V
K
P
V
T
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
54.97
44%
-62
- C4 -
-
2GXS
1
?
A:
[3-205]
--------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
A
------
P
---
S
Q
E
---
R
G
R
----
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
L
K
-----------
V
V
A
V
Y
G
G
T
-
G
Y
--
G
K
Q
K
--
E
A
-
L
L
-
R
--
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
--
L
D
L
S
--
R
V
E
V
A
V
L
D
E
A
D
E
M
L
S
--
M
-
G
F
E
E
E
V
E
-
A
-
L
----
L
S
A
----
T
----
P
P
-------
S
R
--
Q
T
--
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
53.91
38%
-39
- C4 -
-
4PX9
1
DDX3X_HUMAN
A:
[65-290]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
-
E
NGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
V
E--
Q
D
T
----
M
----
P
P
-------
K
G
V
R
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
53.77
38%
-39
- C4 -
-
4PX9
1
DDX3X_HUMAN
B:
[65-290]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
-
E
NGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E
-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
V
E--
Q
D
T
----
M
----
P
P
-------
K
G
V
R
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
53.42
38%
-39
- C4 -
-
4PX9
1
DDX3X_HUMAN
C:
[65-290]
------
E
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
-------
G
E
---
A
L
R
A
M
K
-
E
NGRYGRRKQY
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
-
S
Y
R
S
-----
R
---
V
R
P
C
V
V
Y
G
G
A
-
D
I
--
G
Q
Q
I
--
R
D
-
L
E-
R
--
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
--
I
G
L
D
--
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
D
--
M
-
G
F
E
P
Q
I
R
-
R
-
I
VE--
Q
D
T
----
M
----
P
P
-------
K
G
VR
H
T
--
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
PsiBlast_CBE
52.67
31%
-90
- C4 -
-
2PL3
5
DDX10_HUMAN
A:
[27-232]
--------
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
-----------
Y
R
L
---
Q
W
T
S
T
D
-
G
----------
L
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
-
T
F
E
V
L
R
K
V
G
K
N
H
-----
D
---
F
S
A
G
L
I
I
G
G
---
L
--
K
H
E
A
--
E
R
-
I
--
N
--
N
I
N
I
L
V
C
T
P
G
R
L
L
Q
-
H
M
D
E
-
T
V
S
--
F
H
A
T
--
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
D
--
M
-
G
F
A
D
T
M
N
-
A
-
V
----
I
E
N
----
L
----
P
K
-------
K
R
--
Q
T
--
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
51.78
34%
-73
- C4 -
-
3BER
3
DDX47_HUMAN
A:
[42-249]
-----
T
K
T
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
--
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
L
------
L
E
---
T
P
Q
---
R
L
F
A
-----------------
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
S
I
------
G
---
V
Q
S
A
V
I
V
G
G
I
D
S
M
--
S
Q
S
L
--
A
L
-
A
--
K
--
K
P
H
I
I
I
A
T
P
G
R
L
I
D
H
L
E
N
T
-
K
-
G
--
F
N
L
R
--
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
N
--
M
-
D
F
E
T
E
V
D
-
K
-
I
----
L
K
V
----
I
----
P
R
-------
D
R
--
K
T
--
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
V
K
C
A
V
S
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
48.18
33%
-54
- C4 -
-
3DKP
3
DDX52_HUMAN
A:
[33-241]
----------
E
Y
K
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
H
--
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
Q
L
K
Q
-----
P
---
A
N
K
---
G
F
R
A
-----------------
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
K
-
I
S
E
G
T
-----
G
---
F
R
I
H
M
I
H
K
A
A
-
V
A
--
A
K
K
F
GP
K
S
-
S
--
K
--
K
F
D
I
L
V
T
T
P
N
R
L
I
Y
-
L
L
K
Q
-
D
-
P
PG
I
D
L
A
--
S
V
E
W
L
V
V
D
E
S
D
K
L
F
E
D
G--
G
F
R
D
Q
L
A
-
S
-
I
----
F
-
L
----
A
----
C
T
-------
S
H
--
K
V
R
R
A
M
F
S
A
T
F
A
Y
D
V
E
Q
W
C
K
--
L
N
L
D
N
V
I
S
V
S
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------