@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQD1: (2017-11-26 )
MHLNSSIDKKMTTLNILFKTTSLCLAMALLVGCNDNDDNDSSTPAPRSNQTVNILAFNDFHGNLEPPKRYVEAANPNDASQTVRIPVGGVSYFADAIKKLKAQNPNNVVVSAGDLISASPLTSSLFLDEPTIEVMNDIQIDFNAVGNHEFDRGTDELRRLQNGGCQQYTSTAPCQINKNFSGAKFNFLAANVAMKNDTSKTIFPAYKVKTYGGIPVAFIGLTLKATPSIVSAAGIKDVEFRDEADTVNALIPELQKQGIEAIVVVVHEGAAPSTKLNQKTCDGLSGPILGILDRLNPAVDIVVSGHTHQSYICDYATKNPAKPFLLTSAGQYGTLITDIKVGLDGKTGDIIKKDAKQIPVQSEAYTSGTTTVSLTDLYQKFSKTPSIEAILDKYRQAVTTISGRVVGTSTAVVSRTQVESGESPLGDMIADAQQAAALQASNQGSDFTLMNPGGVRADLLINSSNQITFGDIFAVQPFGNSIVTLSLTGKQIRDVLEQQWSGANANSPRILQPSKELSYQYAANTSVSPRASNIMVAGSPLVDTKVYRVTVNSFLADGGDNFTVLKEGQNRVGGGQDIDALESYVAQNSKDSPLIIPATTRIKVIK
Atome Classification :
(20 SA)
--------.........10........20........30.....---...40........50........60........70........80.....--...90........-100.----.----...----..110.......120.......130.......140.......150.......160........170.......180.......190-......---.---200---.......210.......220-......-.230.......240.......250....-...260.......270....-...280.......290-....------..-..--.300.......310.---------..--------------.--------------..--.320.-----.------------.....330.......340...--------....350--------........360..----..----...370......-.-380.......390....--------...400.......410-..--.--.--....------420.......430.......440--...----......450.......460.......470.......480........490.......500..------.....510..-----..-...520........--530....--------.----..--------540.......550.......560.......570--.--...-.-.--..580.......590.......600.....----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------MHLNSSIDKK
M
T
T
L
N
I
L
F
K
T
T
S
L
C
L
A
M
A
L
L
VGCNDN---DDNDSSTPAPRSN
Q
T
V
N
I
L
A
FNDFHGNLE
P
P
K
R
Y
VEAANPNDAS
Q
T
V
R
I
P--VG
G
V
S
Y
F
A
D
A
I
K
K
-
L
KAQ----N----PN
N
----
V
V
V
SAG
D
L
ISASPLT
S
S
LFLDE
P
T
I
E
V
M
ND
I
Q
I
D
F
NAVGNHEFDR
G
T
D
E
L
R
R
L
-QNGGCQQYTSTA
P
C
Q
INKNFSG
A
K
F
N
F
L
A
A
N
V
-
A
MKNDT---S---K
T
I
---
F
P
A
Y
K
V
K
TYGG
I
P
V
A
F
I
G
L
T
-
L
KATP
S
-
I
V
S
AAGIKD
V
E
FRDEAD
T
V
N
A
L
I
P
E
L
Q
K-QGI
E
A
I
V
V
V
V
HEGAAPSTKL-NQKTCDGLS
G
P
I
L
G
---
I
L
D
R------LN-P
A
--
V
D
I
V
V
SGHT
H
Q
S
Y
I
C---------DY--------------A--------------TK--NPAK
P
-----
F
------------
L
L
TSAGQY
G
T
L
I
T
D
I
K
VGLDG--------KT
G
D
I
I
---------
K
K
D
A
K
QIPVQSEA----YT----SG
T
T
T
V
S
L
T
D
L
Y
-
Q
-
K
FSKTP
S
I
E
A
I
L
D
K
Y
R
Q
--------
A
V
T
T
ISG
R
V
V
GT
S
T
A
--
V
V
--
S
--
R
--
T
QVE------SGES
P
L
G
D
M
I
A
D
A
Q
Q
A
A
A
LQA----SNQ----GS
D
F
T
L
MNPGG
V
R
A
D
L
L
INSSN
Q
I
T
F
G
D
I
F
A
VQPFG
N
-
S
I
V
T
L
S
L
T
G
K
Q
I
R
D
V
L
E
Q
QWSGAN------ANS
P
R
ILQPS-----KE-
L
S
Y
Q
Y-AANTSVSP--RAS
N
I
M
V
--------A----GS--------P
L
V
D
T
K
V
Y
R
V
T
V
N
S
F
LADGGD
N
F
T
V
L
KEGQN-R--V--GGG-Q-
D
--
I
D
A
L
E
S
Y
V
AQNSKDS
P
L
I
I
PAT
T
-
R
I
K
V
IK----------
23
HHSearch
84.87
29%
-14
- C1 -
-
2Z1A
1
?
A:
[28-531]
------------------------------------------------------------
F
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
V
E
L
T
L
---------
S
G
E
K
T
P
--
V
G
G
V
A
R
R
V
A
L
F
D
R
-
V
W
A
R
----
A
----
K
N
P
----
L
F
L
D
A
G
D
V
F
Q
G
T
L
Y
F
-
N
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
P
G
P
L
A
D
F
-
L
K
G
-------------------
A
R
F
K
V
V
S
A
N
V
-
D
A
S
R
E
P
---
R
L--
K
G
L
---
F
A
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
-
T
P
D
T
R
E
-
I
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
D
L
----------------
K
---
L
A
R
R
------
L
--
V
G
--
V
Q
V
I
V
G
G
H
S
H
T
L
L
G
S
---------
F
P
HKELSPAGPY
P
T
V
-
V
--------------
K
N
--
P
E
G
K
D
-----
V
------------
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
A
--------
K
G
-
E
L
L
---------
A
Y
K
G
E
A
L
L
M
T
P
-------------------------
E
-
A
A
P
E
D
F
F
A
K
E
A
L
L
A
Y
A
Q
--------
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
--
D
L
--
V
--
G
ER
A
V
V
R
------
R
R
E
S
N
L
G
N
L
I
T
D
G
M
L
W
K
T
R
N
-------
A
----
G
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
P
---
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
------
N
T
A
G
R
F
L
Q
V
S
------
G
-
L
R
Y
A
F
-
D
L
S
R
P
A
G
S
--
R
V
V
R
V
E
V
--------
K
T
EKG
Y
V
--------
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
A
Q
G
-
Y
RV
D
--
T
G
F
-
S
-
D
--
A
E
S
F
M
D
Y
L
K
E
L
K
---
V
V
E
A
G
L
E
G
-
R
I
E
V
L
-----------
1
PsiBlast_PDB
81.50
27%
-16
- C1 -
-
2Z1A
1
?
A:
[29-516]
-------------------------------------------------------------
T
L
T
L
V
H
T
N
D
T
H
A
H
L
E
P
----
V
E
L
T
L
S
G
E
-----
K
T
P
--
V
G
G
V
A
R
R
V
A
L
F
D
R
-
V
W
A
R
----
A
----
K
N
P
----
L
F
L
D
A
G
D
V
F
Q
G
T
-
L
Y
F
N
Q
Y
R
G
L
A
D
R
Y
F
M
H
R
L
R
Y
R
A
M
A
L
G
N
H
E
F
D
L
G
--------------------
P
G
P
L
A
D
F
L
K
G
A
R
F
K
V
V
S
A
N
V
D
A
S
R
E
P
R
---
L
---
K
G
L
---
F
A
P
Y
A
V
V
V
V
G
G
E
R
V
G
I
I
G
L
T
-
T
P
D
T
R
E
-
I
S
N
P
G
--
P
T
V
A
F
L
D
P
Y
E
S
A
Q
K
A
V
Y
E
L
L
A
-
K
G
V
N
K
I
V
V
L
S
H
L
G
Y
G
E
D
L
K
L
-
A
R
R
L
V
--------------------------
G
--
V
Q
V
I
V
G
G
H
S
H
-
T
L
L
G
---------
S
F
--------------
P
--------------
H
K
EL
S
P
A
G
P
-----
Y
P
T
V
V
K
N
PEG
K
D
V
L
V
V
Q
A
W
E
W
G
K
V
V
G
L
L
E
V
T
F
D
A
--------
K
-
G
E
L
L
---------
A
Y
K
G
E
A
L
L
M
T
P
E
A
----------------
A
P
E
D
F
F
-
A
-
K
-------
E
A
L
L
-
A
Y
A
Q
--------
P
V
M
A
L
M
Q
Q
V
I
A
E
A
K
V
DL
V
G
--
E
--
R
--
A
V
V
R
------
R
R
E
S
N
L
G
N
L
I
T
D
G
M
---
L
W
K
T
----
R
N
A
----
G
T
Q
I
A
L
Q
N
G
G
G
I
R
A
S
I
---
P
K
G
P
I
T
V
G
K
V
Y
E
V
L
P
F
G
N
-
T
L
V
V
M
D
L
K
G
K
E
I
L
A
A
L
E
N
G
V
S
Q
W
E
------
N
T
A
G
R
F
L
Q
V
S
-----
G
--
L
R
Y
A
F
-
D
L
S
R
P
A
G
S
--
R
V
V
R
V
E
V
--------
K
----
T
E
KGYV----
P
L
D
L
E
A
T
Y
R
V
V
V
N
N
F
I
A
N
G
G
D
G
F
T
V
L
K
E
A
Q
G
Y
R
--
V
--
D
T
G
F
S
-
D
--
A
E
S
F
M
D
Y
L
K
E
------------------------------
26
HHSearch
78.66
26%
-7
- C1 -
-
3IVE
1
?
A:
[4-498]
-----------------------------------------------------------
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
--------
I
A
D
G
K
R
D
--
I
G
G
W
A
N
I
T
T
L
V
K
Q
-
E
K
A
K
----
N
----
K
A
T
----
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
S
S
-
L
T
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
-
L
S
Q
-------------------
A
K
F
P
I
V
Q
G
N
I
-
F
Y
Q
N
S
S
---
K
---
S
F
W
---
D
K
P
Y
T
I
I
E
K
D
G
V
K
I
G
V
I
G
L
H
-
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
K
V
D
L
T
V
A
L
I
H
E
G
V
P
A
R
Q
S
S
M---
D
V
R
R
A
L
D
K
D
I
Q
---
T
A
S
Q
------
V
--
K
G
--
L
D
I
L
I
T
G
H
A
H
V
G
T
P
E
---------
P
I
--------------
K
--------------------
V
G
N
-----
T
------------
L
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
K
E
--------
K
P
H
N
F
T
---------
V
K
N
F
E
L
K
T
I
Y
A
-------------------------
D
-
E
W
K
P
D
Q
Q
T
K
Q
V
I
D
G
W
N
K
--------
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
--
E
L
--
K
--
R
----
A
Y
------
G
E
S
A
S
L
G
N
L
A
A
D
A
L
L
A
A
A
G
--------
K
----
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
P
---
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
----------
N
G
V
L
Q
V
S
-----
K
G
-
L
E
M
K
Y
-
D
S
S
K
P
V
G
Q
--
R
V
I
T
L
T
L
--------
N
----
G
K
--------
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
T
E
G
K
A
-
R
--
N
I
T
G
G
Y
-
Y
-
V
--
Y
H
A
V
V
D
Y
F
K
A
G
N
---
T
I
T
D
E
Q
L
N
-
G
M
R
V
K
-----------
25
HHSearch
77.65
26%
-4
- C1 -
-
3IVD
1
?
A:
[3-498]
----------------------------------------------------------
L
A
K
D
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
--------
I
A
D
G
K
R
D
--
I
G
G
W
A
N
I
T
T
L
V
K
Q
-
E
K
A
K
----
N
----
K
A
T
----
W
F
F
D
A
G
D
Y
F
T
G
P
Y
I
S
S
-
L
T
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
L
Q
-
L
S
Q
-------------------
A
K
F
P
I
V
Q
G
N
I
-
F
Y
Q
N
S
S
---
K
---
S
F
W
---
D
K
P
Y
T
I
I
E
K
D
G
V
K
I
G
V
I
G
L
H
-
G
V
F
A
F
N
D
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
--
G
K
V
D
L
T
V
A
L
I
H
E
G
V
P
A
R
Q
S
S
M
G
G
T
D
V
R
R
A
L
D
K
D
I
Q
---
T
A
S
Q
------
V
--
K
G
--
L
D
I
L
I
T
G
H
A
H
V
G
T
P
E
---------
P
I
--------------
K
--------------------
V
G
N
-----
T
------------
L
I
L
S
T
D
S
G
G
I
D
V
G
K
L
V
L
D
Y
K
E
--------
K
P
H
N
F
T
---------
V
K
N
F
E
L
K
T
I
Y
A
-------------------------
D
-
E
W
K
P
D
Q
Q
T
K
Q
V
I
D
G
W
N
K
--------
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
--
E
L
--
K
--
R
----
A
Y
------
G
E
S
A
S
L
G
N
L
A
A
D
A
L
L
A
A
A
G
--------
K
----
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
P
---
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
----------
N
G
V
L
Q
V
S
-----
K
G
-
L
E
M
K
Y
-
D
S
S
K
P
V
G
Q
--
R
V
I
T
L
T
L
--------
N
----
G
K
--------
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
T
E
G
K
A
-
R
--
N
I
T
G
G
Y
-
Y
-
V
--
Y
H
A
V
V
D
Y
F
K
A
G
N
---
T
I
T
D
E
Q
L
N
-
G
M
R
V
K
-----------
42
Fugue
76.84
23%
1
- C1 -
-
3ZTV
2
5NTD_HAEIN
A:
[8-573]
---------------------------------------------------------
H
K
A
V
E
L
S
I
L
H
I
N
D
H
H
S
Y
L
E
P
H
E
T
R
I
N
L
N
G
-----
Q
Q
T
K
V
D
--
I
G
G
F
S
A
V
N
A
K
L
N
K
-
L
R
K
K
----
Y
----
K
N
P
----
L
V
L
H
A
G
D
A
I
T
G
T
L
Y
F
T
-
L
F
G
G
S
A
D
A
A
V
M
N
A
G
N
F
H
Y
F
T
L
G
N
H
E
F
D
A
G
N
E
G
L
L
K
L
-
L
E
P
-------------------
L
K
I
P
V
L
S
A
N
V
-
I
P
D
K
S
S
---
I
L--
Y
N
K
---
W
K
P
Y
D
I
F
T
V
D
G
E
K
I
A
I
I
G
L
D
-
T
V
N
K
T
V
-
N
S
S
S
P
G
-
K
D
V
K
F
Y
D
E
I
A
T
A
Q
I
M
A
N
A
L
K
Q
-
Q
G
I
N
K
I
I
L
L
S
H
A
G
S
E
K
N
I
E
I
-
A
Q
K
-
V
N
D
I
D
V
I
V
T
G
---
D
S
H
Y
------
L
Y
-
G
N
--
D
E
L
R
S
L
K
L
P
V
I
Y
E
Y
P
---------
L
E
--------------
F
--------------
K
N
--
P
N
G
E
P
-----
V
------------
F
V
M
E
G
W
A
Y
S
A
V
V
G
D
L
G
V
K
F
S
P
EG
I
A
S
I
TR
K
I
P
H
V
L
M
S
SH
K
L
Q
V
K
N
S
E
G
K
W
A
E
L
T
G
D
E
----
R
K
----
K
A
L
D
T
L
K
S
M
K
S
I
-
S
-
L
D
D
H
D
A
K
T
D
K
L
I
A
K
Y
K
S
--------
E
K
D
R
L
A
Q
E
I
V
G
V
I
T
G
--
S
A
--
M
--
P
--
G
G
S
A
NRIPNK
A
G
S
N
P
E
G
S
I
A
T
R
F
I
-
A
E
T
M
Y
N
----
E
L
K
----
T
V
D
L
T
I
Q
N
A
G
G
V
R
A
D
I
---
L
P
G
N
V
T
F
N
D
A
Y
T
F
L
P
F
G
N
-
T
L
Y
T
Y
K
M
E
G
S
L
V
K
Q
V
L
E
D
A
M
Q
F
A
L
------
V
D
G
S
T
G
A
F
P
Y
-----
G
A
G
I
R
Y
E
A
N
E
T
P
N
A
E
G
K
--
R
L
V
S
V
E
V
L
NKTQ---
Q
----
W
E
--------
P
I
D
D
N
K
R
Y
L
V
G
T
N
A
Y
V
A
G
G
K
D
G
Y
K
T
F
G
K
L
F
N
D
P
--
K
--
Y
E
G
-
V
-
D
TY
L
P
D
A
E
S
F
I
K
F
M
K
K
H
P
H
F
E
A
Y
T
S
S
-
N
V
K
F
N
A
ST--------
22
HHSearch
73.50
24%
15
- C1 -
-
4H2I
1
5NTD_HUMAN
A:
[2-524]
------------------------------------------------------------
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
S
K
C
------
V
D
A
S
R
C
--
M
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
E
P
L
L
K
E
-------------------
A
K
F
P
I
L
S
A
N
I
-
K
A
K
G
P
L
ASQ
I
---
S
G
L
---
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
F
-
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
----------------
L
---
I
A
Q
K
------
V
--
R
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
---------
G
N
--------------
P
PSKEVPAGKYP
F
I
V
T
S
--
D
D
G
R
K
-----
V
------------
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
G
-
N
V
I
---------
S
S
H
G
N
P
I
L
L
D
--------------------------
S
-
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
--
Y
L
--
D
GS
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
----
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
------
G
-
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
L
C
TKCR
V
P
S
----
Y
D
--------
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
H
-
D
--
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
---
V
I
Y
P
A
V
E
G
-
R
I
K
F
S
-----------
2
PsiBlast_PDB
71.79
27%
-9
- C1 -
-
3IVD
1
?
A:
[7-465]
--------------------------------------------------------------
V
T
I
I
Y
T
N
D
L
H
A
H
V
E
P
Y
K
V
P
W
I
A
D
G
K
R
D
----------
I
G
G
W
A
N
I
T
T
L
V
K
Q
-
E
K
A
K
----
N
----
K
A
T
----
W
F
F
D
A
G
D
Y
F
T
G
-
P
Y
I
S
S
L
T
K
G
K
A
I
I
D
I
M
N
T
M
P
F
D
A
V
T
I
G
N
H
E
F
D
H
G
W
D
N
T
L
-
L
-
Q
------------------
L
S
Q
A
K
F
P
I
V
Q
G
N
I
-
F
Y
Q
N
S
S
---
K
---
S
F
W
---
D
K
P
Y
T
I
I
E
K
D
G
V
K
I
G
V
I
G
L
H
G
V
F
A
F
N
D
-
T
V
S
A
A
T
R
V
G
I
E
A
R
D
E
I
K
W
L
Q
R
Y
I
D
E
L
K
G
-
K
-
V
D
L
T
V
A
L
I
H
E
G
V
-
P
A
R
Q
S
-
S
M
G
G
T
D
-----
V
R
R
---
A
L
D
K
D
I
Q
T
A
S
Q
V
-
K
G
--
L
D
I
L
I
T
G
H
A
H
---------------
V
--------------
G
--------------
T
P
--
E
P
I
K
-----------------------
V
G
N
T
L
I
L
S
T
D
-
S
G
G
I
D
----------
V
G
K
L
V
---------
L
-
D
Y
K
E
K
P
---------
H
N
----
F
T
V
K
N
F
E
L
K
T
I
Y
A
D
-
E
W
K
P
D
Q
Q
T
K
Q
V
I
D
G
W
N
K
--------
K
L
D
E
V
V
Q
Q
T
V
A
Q
S
P
V
--
E
L
--
K
--
R
--
A
Y
G
E
------
S
A
S
------
L
G
N
L
A
A
D
A
L
L
A
A
----
A
G
K
----
N
T
Q
L
A
L
T
N
S
G
G
I
R
N
E
I
---
P
A
G
A
I
T
M
G
G
V
I
S
T
F
P
F
P
N
-
E
L
V
T
M
E
L
T
G
K
Q
L
R
S
L
M
E
H
G
A
S
L
S
N
------
G
----
V
L
Q
V
S
-----
K
G
-
L
E
M
K
Y
-
D
S
S
K
P
V
G
Q
--
R
V
I
T
L
T
L
--------
N
----
G
K
--------
P
I
E
D
A
T
V
Y
H
I
A
T
Q
S
F
L
A
D
G
G
D
G
F
T
A
F
T
E
G
K
A
-
R
------------------------------------------------------
10
PsiBlast_PDB
71.20
24%
-6
- C1 -
-
1OI8
-
USHA_ECOLI
A:
[37-511]
---------------------------------------------------------------------------------------------------------
L
V
D
G
I
R
K
-
E
V
A
A
----
E
----
G
G
S
----
V
L
L
L
S
G
G
D
I
N
T
G
V
C
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
-
E
-------------------
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-
T
---
G
---
E
R
L
---
F
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
-
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
-------
H
G
S
N
A
P
G
D
V
---
E
M
A
R
------
A
L
-
P
A
GS
L
A
M
I
V
G
G
H
S
-
Q
D
P
V
C
MAAENKKQV
D
Y
--------------
V
--------------
P
G
--
T
P
C
K
P
D
Q
Q
NG
I
------------
W
I
V
Q
A
H
E
W
G
K
Y
V
G
--
R
A
D
F
E
F
--------
R
N
G
E
M
K
---------
M
V
N
Y
Q
L
I
P
V
N
L
K
K
----
K
V
----
T
W
E
D
G
K
S
E
R
V
L
Y
-
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
R
L
E
G
----------
D
--
R
--
D
K
V
R
------
F
V
Q
T
N
M
G
R
L
I
------
L
A
A
Q
M
----
D
R
T
----
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
C
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
---------------
T
A
V
A
Q
M
K
P
D
-----
S
G
-
A
Y
P
Q
F
-
A
N
V
S
F
V
A
K
DG
K
L
N
D
L
K
I
--------
K
----
G
E
--------
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
-
Y
--
V
--
N
T
G
-
F
I
D
--
A
E
V
L
K
A
Y
I
---
Q
K
S
S
P
L
-----------------------
24
HHSearch
70.05
24%
10
- C1 -
-
4H2G
1
5NTD_HUMAN
A:
[23-545]
-----------------------------------------------------------
P
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
D
S
S
K
C
------
V
D
A
S
R
C
--
M
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
I
W
F
T
-
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
I
E
P
L
L
K
E
-------------------
A
K
F
P
I
L
S
A
N
I
-
K
A
K
G
P
L
---
A
S
Q
I
S
G
L
---
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
F
-
L
S
N
P
G
--
T
N
L
V
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
----------------
L
---
I
A
Q
K
------
V
--
R
G
--
V
D
V
V
V
G
G
H
S
N
T
F
L
Y
T
---------
G
N
PPSKEVPAGKYPFI
V
--------------
T
S
--
D
D
G
R
K
-----
V
------------
P
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
G
-
N
V
I
---------
S
S
H
G
N
P
I
L
L
D
--------------------------
S
-
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
--
Y
L
--
D
GS
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
ADEM
F
W
N
----
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
------
G
-
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
L
C
TACA
V
P
S
----
Y
D
--------
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
H
-
D
--
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
---
V
I
Y
P
A
V
E
G
-
R
I
K
F
------------
15
PsiBlast_PDB
69.61
23%
17
- C1 -
-
4H2I
1
5NTD_HUMAN
A:
[4-522]
--------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
--
D
S
S
K
C
V
D
A
S
R
C
M
------
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
-
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-------------------
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
-
K
A
K
G
P
L
---
A
---
S
Q
I
SGL
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
--
F
L
S
N
P
G
T
N
L
V
-
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
L
I
-
A
Q
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
------
G
N
-
P
P
--
S
K
E
V
P
A
G
K
Y
P
F
I
V
T
S
---------
D
D
--------------
G
--------------
R
K
--
V
P
----------------------
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
-
G
N
V
I
---------
S
S
H
G
N
P
I
L
L
D
S
S
---------------------------
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
--
Y
L
DG
S
--
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
----
A
D
E
MFWN
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
-----
G
--
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
--------
L
----
C
T
KCR
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
--
H
D
-
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
----
V
I
Y
P
A
V
E
G
R
I
K
-------------
16
PsiBlast_PDB
68.96
23%
36
- C1 -
-
4H1S
1
5NTD_HUMAN
A:
[4-522]
--------------------------------------------------------------
L
T
I
L
H
T
N
D
V
H
S
R
L
E
--------
Q
T
S
E
D
S
S
K
C
V
N
A
S
RC
M
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
-
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-------------------
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
-
K
A
K
G
P
L
---
A
---
S
Q
I
SGL
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
--
F
L
S
N
P
G
T
N
L
V
-
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
L
I
-
A
Q
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
------
G
N
-
P
P
--
S
K
E
V
P
A
G
K
Y
P
F
I
V
T
S
---------
D
D
--------------
G
--------------
R
K
--
V
P
----------------------
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
-
G
N
V
I
---------
S
S
H
G
N
P
I
L
L
N
S
S
---------------------------
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
N
Y
--
Q
E
L
G
K
T
I
V
--
Y
L
DG
S
--
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
----
T
D
E
MFWN
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
N
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
-----
G
--
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
--------
L
----
C
T
KCR
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
--
H
D
-
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
----
V
I
Y
P
A
V
E
G
R
I
K
-------------
11
PsiBlast_PDB
67.78
24%
22
- C1 -
-
4H2F
1
5NTD_HUMAN
A:
[23-544]
--------------------------------------------------------
P
---
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
--
D
S
S
K
C
V
D
A
S
R
C
M
------
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
-
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-------------------
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
-
K
A
K
G
P
L
---
A
---
S
Q
I
SGL
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
--
F
L
S
N
P
G
T
N
L
V
-
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
L
I
-
A
Q
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
------
G
N
-
P
P
--
S
K
E
V
P
A
G
K
Y
P
F
I
V
T
S
---------
D
D
--------------
G
--------------
R
K
--
V
P
----------------------
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
-
G
N
V
I
---------
S
S
H
G
N
P
I
L
L
D
S
S
---------------------------
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
--
Y
L
DG
S
--
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
----
A
D
E
MFWN
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
-----
G
--
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
--------
L
----
C
T
ACAV
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
--
H
D
-
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
----
V
I
Y
P
A
V
E
G
R
I
K
-------------
14
PsiBlast_PDB
67.67
24%
16
- C1 -
-
4H1Y
2
5NTD_HUMAN
P:
[23-544]
--------------------------------------------------------
P
---
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
--
D
S
S
K
C
V
D
A
S
R
C
M
------
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
-
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-------------------
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
-
S
A
S
G
P
L
---
A
---
S
Q
I
SGL
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
--
F
L
S
N
P
G
T
N
L
V
-
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
L
I
-
A
Q
K
V
R
G
V
D
V
V
V
G
G
H
SNT
F
L
Y
T
------
G
N
-
P
P
--
S
K
E
V
P
A
G
K
Y
P
F
I
V
T
S
---------
D
D
--------------
G
--------------
R
K
--
V
P
----------------------
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
-
G
N
V
I
---------
S
S
H
G
N
P
I
L
L
D
S
---------------------------
S
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
--
Y
L
DG
S
--
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
----
A
D
E
MFWN
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
-----
G
--
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
--------
L
----
C
T
SCRVPSYD
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
--
H
D-
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
----
V
I
Y
P
A
V
E
G
R
I
K
-------------
12
PsiBlast_PDB
67.57
24%
16
- C1 -
-
4H2G
1
5NTD_HUMAN
A:
[23-544]
--------------------------------------------------------
P
---
W
E
L
T
I
L
H
T
N
D
V
H
S
R
L
E
Q
T
S
E
--
D
S
S
K
C
V
D
A
S
R
C
M
------
G
G
V
A
R
L
F
T
K
V
Q
Q
-
I
R
R
A
----
E
----
P
N
V
----
L
L
L
D
A
G
D
Q
Y
Q
G
T
-
I
W
F
T
V
Y
K
G
A
E
V
A
H
F
M
N
A
L
R
Y
D
A
M
A
L
G
N
H
E
F
D
N
G
V
E
G
L
-------------------
I
E
P
L
L
K
E
A
K
F
P
I
L
S
A
N
I
-
K
A
K
G
P
L
---
A
---
S
Q
I
SGL
Y
L
P
Y
K
V
L
P
V
G
D
E
V
V
G
I
V
G
Y
T
-
S
K
E
T
P
--
F
L
S
N
P
G
T
N
L
V
-
F
E
D
E
I
T
A
L
Q
P
E
V
D
K
L
K
T
-
L
N
V
N
K
I
I
A
L
G
H
S
G
F
E
M
D
K
L
I
-
A
Q
K
V
R
G
V
D
V
V
V
G
G
H
SN
T
F
L
Y
T
------
G
N
-
P
P
--
S
K
E
V
P
A
G
K
Y
P
F
I
V
T
S
---------
D
D
--------------
G
--------------
R
K
--
V
P
----------------------
V
V
Q
A
Y
A
F
G
K
Y
L
G
Y
L
K
I
E
F
D
E
--------
R
-
G
N
V
I
---------
S
S
H
G
N
P
I
L
L
D
S
S
---------------------------
I
P
E
D
P
S
I
K
A
D
I
N
K
W
R
I
--------
K
L
D
D
Y
S
T
Q
E
L
G
K
T
I
V
--
Y
L
DG
S
--
S
--
Q
S
C
R
------
F
R
E
C
N
M
G
N
L
I
C
D
A
M
I
N
N
N
L
R
H
----
A
D
E
MFWN
H
V
S
M
C
I
L
N
G
G
G
I
R
S
P
I
D
E
R
N
D
G
T
I
T
W
E
N
L
A
A
V
L
P
F
G
G
-
T
F
D
L
V
Q
L
K
G
S
T
L
K
K
A
F
E
H
S
V
H
R
Y
G
------
Q
S
T
G
E
F
L
Q
V
G
-----
G
--
I
H
V
V
Y
-
D
L
S
R
K
P
G
D
--
R
V
V
K
L
D
V
--------
L
----
C
T
ACA
V
P
S
Y
D
P
L
K
M
D
E
V
Y
K
V
I
L
P
N
F
L
A
N
G
G
D
G
F
Q
M
I
K
D
E
L
L
-
R
--
H
D
-
S
G
D
-
Q
-
D
--
I
N
V
V
S
T
Y
I
S
K
M
K
----
V
I
Y
P
A
V
E
G
R
I
K
-------------
46
Fugue
66.74
19%
15
- C1 -
-
2WDC
12
?
A:
[21-562]
YDLPPYGD
A
T
L
L
Y
F
S
D
L
H
G
Q
A
F
P
H
Y
F
M
E
P
P
N
L
I
A
P
K
P
L
M
G
R
P
G
Y
LTG
E
A
I
L
R
Y
Y
G
V
E
R
G
T
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
F
G
-----------------
P
--
I
G
G
M
G
A
L
T
A
L
I
R
D
-
Q
K
A
R
----
V
----
E
A
E
G
G
K
A
L
V
L
D
G
G
D
T
W
T
N
S
-
G
L
S
L
L
T
R
G
E
A
V
V
R
W
Q
N
L
V
G
V
D
-
H
M
V
S
H
W
E
W
T
L
G
R
E
R
V
E
E
L
-
L
G
L
-------------------
F
R
G
E
F
L
S
Y
N
I
--
V
D
D
L
F
---
G
---
D
P
L
---
F
P
A
Y
R
I
H
R
V
G
P
Y
A
L
A
V
V
G
A
S
-
Y
P
Y
V
K
V
-
S
H
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
H
N
G
M
Q
L
D
A
A
L
-
A
E
R
I
--------------------------
R
G
--
I
D
L
I
L
S
G
H
T
H
D
L
T
P
R
---------
P
W
--------------
R
--------------
V
G
--
K
---------
T
------------
W
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
W
K
----------
G
G
I
A
---------
N
L
R
V
R
V
L
P
V
L
A
E
H
--------------------------
L
P
K
A
E
D
V
E
A
F
L
K
A
Q
L
A
--------
P
H
Q
D
H
L
F
T
P
L
A
V
S
E
T
--
L
L
--
Y
--
K
--
R
D
--------
T
L
Y
S
T
W
D
Q
L
V
G
E
A
V
K
A
I
---------------
Y
P
E
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
L
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
------
T
S
D
P
F
Y
Q
Q
G
G
D
V
S
R
V
F
G
-
L
R
Y
V
L
-
D
P
D
A
P
T
G
E
--
R
V
R
E
V
E
V
--------
G
----
G
R
--------
P
L
D
P
N
R
R
Y
L
A
A
A
Y
-----
G
G
R
L
Q
R
V
G
E
A
K
P
---------
G
Y
-
E
-
P
--
R
P
I
Y
E
V
L
A
E
Y
L
R
S
V
G
R
V
R
V
R
P
E
P
-
N
V
K
V
I
G
R
N
Y
R
L
P
EVTG
29
HHSearch
66.49
23%
48
* C1 *
-
1HPU
1
USHA_ECOLI
B:
[4-509]
---------------------------------------------------------
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
----------------
G
--
E
Y
G
L
A
A
Q
K
T
L
V
D
G
-
I
R
K
E
VAAE
G
----
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
-
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
-
E
K
W
-------------------
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
T
G
---
E
----
R
L
---
F
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
-
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
-
G
S
N
-----
A
P
G
D
V
E
---
M
A
R
A
------
L
P
A
G
S
--
L
A
M
I
V
G
G
H
S
Q
D
P
V
C
M
---------
A
A
--------------
E
NKKQVDYVPGTPC-
K
P
--
D
Q
Q
N
G
-----
I
------------
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
--------
G
E
M
--
K
---------
M
V
N
Y
Q
L
I
P
V
N
L
K
K
----
K
V
T---
W
E
D
G
K
S
E
R
V
L
Y
T
-
P
-
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
--------
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
--
R
L
--
E
GD
R
--
D
K
V
R
------
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
--------------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
-------
D
S
G
A
Y
P
Q
F
A
------
N
-
V
S
F
V
A
-
K
D
-----
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
--------
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
-
Y
--
V
N-
T
G
F
-
I
-
D
--
A
E
V
L
K
A
Y
I
Q
K
S
S
----------------------------
31
HHSearch
66.42
19%
1
- C1 -
-
2WDC
11
?
A:
[78-552]
---------------------------------------------------------
R
G
T
P
L
A
Y
L
L
S
Y
V
D
F
V
E
L
A
R
T
F
G
-----------------
P
--
I
G
G
M
G
A
L
T
A
L
I
R
D
-
Q
K
A
R
V
E
A
E
G
----
G
K
A
----
L
V
L
D
G
G
D
T
W
T
N
S
G
L
S
-
L
L
T
R
G
E
A
V
V
R
W
Q
N
L
V
G
V
D
H
M
V
-
S
H
W
E
W
T
L
G
R
E
R
V
E
E
L
-
L
G
L
-------------------
F
R
G
E
F
L
S
Y
N
I
-
V
D
D
L
F
G
---
D
----
P
L
---
F
P
A
Y
R
I
H
R
V
G
P
Y
A
L
A
V
V
G
A
S
-
Y
P
Y
V
K
V
-
S
H
P
E
S
F
T
E
G
L
S
F
A
L
D
E
R
R
L
Q
E
A
V
D
K
A
R
A
-
E
G
A
N
A
V
V
L
L
S
H
N
G
M
Q
L
D
A
----------------
A
---
L
A
E
R
------
I
--
R
G
--
I
D
L
I
L
S
G
H
T
H
D
L
T
P
R
---------
P
W
--------------
R
--------------------
V
G
K
-----
T
------------
W
I
V
A
G
S
A
A
G
K
A
L
M
R
V
D
L
K
L
W
K
--------
G
G
--
I
A
---------
N
L
R
V
R
V
L
P
V
L
A
-------------------------
E
-
H
L
P
K
A
E
D
V
E
A
F
L
K
A
Q
L
A
--------
P
H
Q
D
H
L
F
T
P
L
A
V
S
E
T
--
L
L
--
Y
--
K
--
R
--
D
------
T
L
Y
S
T
W
D
Q
L
V
G
E
A
V
K
A
I
Y
---------
P
----
E
V
E
V
V
F
S
P
A
V
R
W
G
T
T
I
L
--
P
G
Q
A
I
T
W
D
H
L
Y
A
Y
T
G
F
T
Y
P
E
L
Y
L
F
Y
L
R
G
A
Q
I
K
A
V
L
E
D
I
A
S
N
V
F
TSDPFY
Q
Q
G
G
D
V
S
R
V
F
------
G
-
L
R
Y
V
L
-
D
P
D
A
P
T
G
E
--
R
V
R
E
V
E
V
--------
G
----
G
R
--------
P
L
D
P
N
R
R
Y
L
A
A
A
Y
G
-----
G
R
-
L
Q
R
V
G
E
A
K
P
-
G
--
Y
--
E
P
R
-
P
-
I
--
Y
E
V
L
A
E
Y
L
R
S
V
G
---
R
V
R
V
R
P
E
P
-
N
V
K
V
I
G
----------
5
PsiBlast_PDB
66.25
24%
26
- C1 -
-
4WWL
2
USHA_ECOLI
A:
[37-511]
---------------------------------------------------------------------------------------------------------
L
V
D
G
I
R
K
E
V
A
A
E
----
G
----
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
-
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
-
E
-------------------
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-
T
---
G
---
E
R
L
---
F
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
-
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
-------
H
G
S
N
A
P
G
D
V
---
E
M
A
R
------
A
L
-
P
A
GS
L
A
M
I
V
G
G
H
S
-
Q
D
P
V
C
MAAENKKQV
D
Y
--------------
V
--------------
P
G
--
T
P
C
K
P
D
Q
Q
NG
I
------------
W
I
V
Q
A
H
E
W
G
K
Y
V
G
--
R
A
D
F
E
F
--------
R
N
G
E
M
K
---------
M
V
N
Y
Q
L
I
P
V
N
L
K
K
----
K
V
----
T
W
E
D
G
K
S
E
R
V
L
Y
-
T
P
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
K
G
K
A
Q
L
EV
K
I
G
E
T
N
G
R
L
E
G
----------
D
--
R
--
D
K
V
R
------
F
V
Q
T
N
M
G
R
L
I
------
L
A
A
Q
M
----
D
R
T
----
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
---------------
T
A
V
A
Q
M
K
P
D
-----
S
G
-
A
Y
P
Q
F
-
A
N
V
S
F
V
A
K
DG
K
L
N
D
L
K
I
--------
K
----
G
E
--------
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
-
Y
--
V
--
N
T
G
F
C
-
D
--
A
E
V
L
K
A
Y
I
---
Q
K
S
S
P
L
-----------------------
28
HHSearch
66.18
23%
37
- C1 -
-
1HP1
1
USHA_ECOLI
A:
[4-500]
---------------------------------------------------------
D
K
T
Y
K
I
T
V
L
H
T
N
D
H
H
G
H
F
W
R
N
E
Y
----------------
G
--
E
Y
G
L
A
A
Q
K
T
L
V
D
G
-
I
R
K
E
----
V
A
A
E
G
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
E
S
-
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
-
E
K
W
-------------------
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
T
G
---
E
----
R
L
---
F
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
-
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
H
-
G
S
N
-----
A
P
G
D
V
E
---
M
A
R
A
------
L
P
A
G
S
--
L
A
M
I
V
G
G
H
S
Q
D
P
V
C
M
---------
A
A
--------------
E
NKKQVDYVPG
T
P
C
-
K
P
--
D
Q
Q
N
G
-----
I
------------
W
I
V
Q
A
H
E
W
G
K
Y
V
G
R
A
D
F
E
F
R
N
--------
G
E
--
M
K
---------
M
V
N
Y
Q
L
I
P
V
N
L
K
K
----
K
---------
R
V
---
L
Y
T
-
P
-
E
I
A
E
N
Q
Q
M
I
S
L
L
S
P
F
Q
N
--------
K
G
K
A
Q
L
E
V
K
I
G
E
T
N
G
--
R
L
--
E
--
G
D
R
D
K
V
R
------
F
V
Q
T
N
M
G
R
L
I
L
A
A
Q
M
D
R
T
--------------
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
E
---
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
T
A
V
A
Q
M
K
P
-------
D
S
G
A
Y
P
Q
F
A
------
N
-
V
S
F
V
A
-
K
D
-----
G
--
K
L
N
D
L
K
I
--------
K
----
G
E
--------
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
-
Y
--
V
N-
T
G
F
-
I
-
D
--
A
E
V
L
K
A
Y
I
Q
K
S
S
----------------------------
13
PsiBlast_PDB
65.93
25%
22
- C1 -
-
1HP1
1
USHA_ECOLI
A:
[37-502]
---------------------------------------------------------------------------------------------------------
L
V
D
G
I
R
K
E
V
A
A
E
----
G
----
G
S
V
----
L
L
L
S
G
G
D
I
N
T
G
V
P
-
E
S
D
L
Q
D
A
E
P
D
F
R
G
M
N
L
V
G
Y
D
A
M
A
I
G
N
H
E
F
D
N
P
L
T
V
L
R
Q
Q
-
E
-------------------
K
W
A
K
F
P
L
L
S
A
N
I
-
Y
Q
K
S
-
T
---
G
---
E
R
L
---
F
K
P
W
A
L
F
K
R
Q
D
L
K
I
A
V
I
G
L
T
-
T
D
D
T
A
K
-
I
G
N
P
E
Y
F
T
D
I
E
F
R
K
P
A
D
E
A
K
L
V
I
Q
E
L
Q
Q
T
E
K
P
D
I
I
I
A
A
T
H
M
G
H
Y
D
N
G
E
-------
H
G
S
N
A
P
G
D
V
---
E
M
A
R
------
A
L
-
P
A
GS
L
A
M
I
V
G
G
H
S
-
Q
D
P
V
C
MAAENKKQV
D
Y
--------------
V
--------------
P
G
--
T
P
C
K
P
D
Q
Q
NG
I
------------
W
I
V
Q
A
H
E
W
G
K
Y
V
G
--
R
A
D
F
E
F
--------
R
N
G
E
M
K
---------
M
V
N
Y
Q
L
I
P
V
N
L
K
K
KRVL
Y
T
PEIA
E
N
Q
Q
M
I
S
L
L
S
P
F
-
Q
-
N
K
G
K
A
--------
Q
L
E
V
--------
K
I
G
E
T
N
G
R
L
E
G
----------
D
--
R
--
D
K
V
R
------
F
V
Q
T
N
M
G
R
L
I
------
L
A
A
Q
M
----
D
R
T
----
G
A
D
F
A
V
M
S
G
G
G
I
R
D
S
I
---
E
A
G
D
I
S
Y
K
N
V
L
K
V
Q
P
F
G
N
-
V
V
V
Y
A
D
M
T
G
K
E
V
I
D
Y
L
---------------
T
A
V
A
Q
M
K
P
D
-----
S
G
-
A
Y
P
Q
F
-
A
N
V
S
F
V
A
K
DG
K
L
N
D
L
K
I
--------
K
----
G
E
--------
P
V
D
P
A
K
T
Y
R
M
A
T
L
N
F
N
A
T
G
G
D
G
Y
P
R
L
D
N
K
P
G
-
Y
--
V
--
N
T
G
-
F
I
D
--
A
E
V
L
K
A
Y
I
---
Q
K
S
S
P
L
-----------------------