@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQD8: (2017-11-26 )
MISYEKTDMNHGTFPVFDGHNDVLTRLWLSDHNNPAQAFIQEGLAGHLDLKRCQQAGFVGGMFAIFLPPFHYVKQHHPNKLFDQDASDFTQQQIEHICLAQLDLAKQLAEYSNDIQICTTVQDIQHCLTQQKLAIILHMEGAEALQHNPDLLDVFYDAGLRSIGPLWNRPSRFGHGLNAKFPHSPDTGAGLTNEGKAFIKRCADKKMVIDVSHMNERAFWDTANILQQPIVATHSNVHALCPQARNLTDNQLKAIKDSKGIVGLNFDVAFLRKDGQRDANTSIEVLLEHLEYLIDQMGENHVGFGSDFDGALISHEIEDVRGLHLLIEAMQKRHYSNEIIEKICFSNWLTVLNRILDK
Atome Classification :
(22 SA)
.........10........20--.--.......30....---....40........50........60..-......70.......-------.80..-------......90-----.........100.-....-..110........120.......130.......140.......150.......160.....---------..170.......180.--......190.......200.......210.......220.......--230.......240.......250.......260..-------------------------------.....270.-..---------------------.----------------------------------------------------...280........290.......300.......310-.-..--.-...320.......330.......340.......350......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MISYEKTDMNHGT
F
P
VFDGH
N
--
D
--
V
L
T
R
L
W
LSDHN
N
P
---
A
Q
A
F
I
Q
EGLAG
H
L
D
L
K
R
C
Q
QAGFVGG
M
F
-
A
I
FLP
P
F
H
Y
V
K
QHH
P
-------
N
K
L
F
D-------Q
D
A
S
D
F
T
------
Q
Q
Q
I
E
H
I
C
L
A
Q
L
D
-
L
A
K
Q
-
L
A
E
-YSND
I
Q
I
C
T
T
V
Q
D
I
Q
H
C
L
T
Q
Q
K
L
A
I
I
L
HME
G
A
E
A
LQHNP
D
L
L
D
V
F
Y
D
AG
L
R
SIGPLW---------NR
P
S
RFGHGLNAKFPH--SPDTGAGLTNE
G
K
A
F
I
K
R
CADK
K
M
V
I
D
VSHMNERAFW
D
T
A
N
I
L
QQ
P
--
I
V
ATHS
N
V
H
A
LCPQARNL
T
D
N
Q
L
K
A
IKDSK
G
I
V
G
L-------------------------------NF
D
V
A
F
L
RK-DG---------------------Q----------------------------------------------------RDAN-
T
S
I
E
V
L
L
E
H
L
E
Y
L
I
D
QMGENHVGFGSDFD
G
A
L
-
I
-
S
H
--
E
-
I
E
D
V
R
G
L
H
L
L
I
E
A
M
Q
K
RHY
S
N
E
I
I
E
K
I
C
F
S
N
W
L
T
V
L
N
R
I
LDK
26
HHSearch
88.02
43%
-1
- C2 -
-
3LY0
1
?
A:
[5-355]
-----------
D
T
I
P
V
F
D
G
H
N
--
D
--
F
L
L
R
L
L
R
N
P
A
N
R
E
---
T
-
I
W
L
K
G
D
G
T
G
H
L
D
L
P
R
M
K
E
G
G
F
A
G
G
F
F
-
A
I
Y
V
P
S
P
Q
A
H
D
A
A
H
F
E
A
M
M
D
A
P
P
F
E
L
P
L
P
P
MIR
A
E
Q
A
Q
P
V
A
--------------
L
A
M
A
G
-
H
L
L
W
M
E
R
A
-
A
R
G
R
F
K
V
C
R
T
A
A
E
V
R
S
C
H
A
D
G
I
V
S
G
I
M
H
M
E
G
A
E
A
I
G
A
D
L
D
A
L
H
L
F
H
S
L
G
L
R
S
L
G
P
V
W
---------
S
R
P
T
V
F
G
H
G
V
P
F
R
F
P
G
--
S
P
D
T
G
E
G
L
T
E
A
G
R
R
L
V
A
E
C
N
R
L
K
I
M
L
D
L
S
H
L
N
E
K
G
F
D
D
V
A
R
L
S
D
A
P
--
L
V
A
T
H
S
N
A
H
A
V
T
P
S
T
R
N
L
T
D
R
Q
L
A
M
I
R
E
S
R
G
M
V
G
L
-------------------------------
N
F
A
T
S
F
L
R
E
-
D
G
---------------------
R
----------------------------------------------------
R
S
A
E
-
M
G
W
E
P
V
L
R
H
L
D
H
L
I
D
R
L
G
E
D
H
V
G
M
G
S
D
F
D
G
A
T
-
I
-
P
Q
--
G
-
I
A
D
V
T
G
L
P
A
L
Q
A
A
M
R
A
H
G
Y
D
E
P
L
M
R
K
L
C
H
E
N
W
Y
G
L
L
E
R
T
W
--
27
HHSearch
84.44
43%
1
- C2 -
-
3FDG
-
?
B:
[3-354]
-----------
E
T
I
P
V
F
D
G
H
N
--
D
--
F
L
L
R
L
L
R
N
P
A
N
R
E
---
T
-
I
W
L
K
G
D
G
T
G
H
L
D
L
P
R
M
K
E
G
G
F
A
G
G
F
F
-
A
I
Y
V
P
S
P
-----
A
H
F
E
A
M
M
DAP
P
F
E
L
P
L
PPMIR
A
E
Q
A
Q
P
V
A
--------------
L
A
M
A
G
-
H
L
L
W
M
E
R
A
-
A
R
G
R
F
K
V
C
R
T
A
A
E
V
R
S
C
H
A
D
G
I
V
S
G
I
M
H
M
E
G
A
E
A
I
G
A
D
L
D
A
L
H
L
F
H
S
L
G
L
R
S
L
G
P
V
W
---------
S
R
P
T
V
F
G
H
G
V
P
F
R
F
P
G
--
S
P
D
T
G
E
G
L
T
E
A
G
R
R
L
V
A
E
C
N
R
L
K
I
M
L
D
L
S
H
L
N
E
K
G
F
D
D
V
A
R
L
S
D
A
P
--
L
V
A
T
H
S
N
A
H
A
V
T
P
S
T
R
N
L
T
D
R
Q
L
A
M
I
R
E
S
R
G
M
V
G
L
-------------------------------
N
F
A
T
S
F
L
R
E
-
D
G
---------------------
R
----------------------------------------------------
R
S
A
E
-
M
G
W
E
P
V
L
R
H
L
D
H
L
I
D
R
L
G
E
D
H
V
G
M
G
S
D
F
D
G
A
T
-
I
-
P
Q
--
G
-
I
A
D
V
T
G
L
P
A
L
Q
A
A
M
R
A
H
G
Y
D
E
P
L
M
R
K
L
C
H
E
N
W
Y
G
L
L
E
R
S
W
G
-
1
PsiBlast_PDB
84.43
42%
-2
- C2 -
-
3FDG
-
?
A:
[4-351]
------------
T
I
P
V
F
D
G
H
N
--
D
--
F
L
L
R
L
-
L
R
N
P
A
N
R
---
E
T
I
W
L
K
G
D
G
T
G
H
L
D
L
P
R
M
K
E
G
G
F
A
G
G
F
F
-
A
I
Y
V
P
S
P
-----------------------------
P
F
E
L
P
L
PPMIR
A
E
Q
A
Q
P
V
A
L
A
M
A
G
H
L
L
W
M
-
E
R
A
-
A
R
G
R
F
K
V
C
R
T
A
A
E
V
R
S
C
H
A
D
G
I
V
S
G
I
M
H
M
E
G
A
E
A
I
G
A
D
L
D
A
L
H
L
F
H
S
L
G
L
R
S
L
G
P
V
W
---------
S
R
P
T
V
F
G
H
G
V
P
F
R
F
P
G
--
S
P
D
T
G
E
G
L
T
E
A
G
R
R
L
V
A
E
C
N
R
L
K
I
M
L
D
L
S
H
L
N
E
K
G
F
D
D
V
A
R
L
S
D
A
P
--
L
V
A
T
H
S
N
A
H
A
V
T
P
S
T
R
N
L
T
D
R
Q
L
A
M
I
R
E
S
R
G
M
V
G
L
-------------------------------
N
F
A
T
S
F
L
R
E
-
D
G
---------------------
R
----------------------------------------------------
R
S
A
E
-
M
G
W
E
P
V
L
R
H
L
D
H
L
I
D
R
L
G
E
D
H
V
G
M
G
S
D
F
D
G
A
T
-
I
-
P
Q
--
G
-
I
A
D
V
T
G
L
P
A
L
Q
A
A
M
R
A
H
G
Y
D
E
P
L
M
R
K
L
C
H
E
N
W
Y
G
L
L
E
R
----
2
PsiBlast_PDB
84.09
42%
-1
- C2 -
-
3LY0
1
?
A:
[6-353]
------------
T
I
P
V
F
D
G
H
N
--
D
--
F
L
L
R
L
-
L
R
N
P
A
N
R
---
E
T
I
W
L
K
G
D
G
T
G
H
L
D
L
P
R
M
K
E
G
G
F
A
G
G
F
F
-
A
I
Y
V
P
S
P
Q
A
H
D
A
A
H
F
-------
E
A
M
M
D
-------
A
P
P
F
E
L
P
L
P
P
MIR
A
E
Q
A
Q
P
V
A
L
A
M
A
G
H
L
L
W
M
-
E
R
A
-
A
R
G
R
F
K
V
C
R
T
A
A
E
V
R
S
C
H
A
D
G
I
V
S
G
I
M
H
M
E
G
A
E
A
I
G
A
D
L
D
A
L
H
L
F
H
S
L
G
L
R
S
L
G
P
V
W
---------
S
R
P
T
V
F
G
H
G
V
P
F
R
F
P
G
--
S
P
D
T
G
E
G
L
T
E
A
G
R
R
L
V
A
E
C
N
R
L
K
I
M
L
D
L
S
H
L
N
E
K
G
F
D
D
V
A
R
L
S
D
A
P
--
L
V
A
T
H
S
N
A
H
A
V
T
P
S
T
R
N
L
T
D
R
Q
L
A
M
I
R
E
S
R
G
M
V
G
L
-------------------------------
N
F
A
T
S
F
L
R
E
-
D
G
---------------------
R
----------------------------------------------------
R
S
A
E
-
M
G
W
E
P
V
L
R
H
L
D
H
L
I
D
R
L
G
E
D
H
V
G
M
G
S
D
F
D
G
A
T
-
I
-
P
Q
--
G
-
I
A
D
V
T
G
L
P
A
L
Q
A
A
M
R
A
H
G
Y
D
E
P
L
M
R
K
L
C
H
E
N
W
Y
G
L
L
E
R
----
22
PsiBlast_CBE
83.78
42%
-0
- C2 -
-
3LY0
1
?
B:
[6-353]
------------
T
I
P
V
F
D
G
H
N
--
D
--
F
L
L
R
L
-
L
R
N
P
A
N
R
---
E
T
I
W
L
K
G
D
G
T
G
H
L
D
L
P
R
M
K
E
G
G
F
A
G
G
F
F
-
A
I
Y
V
P
S
P
Q
A
H
D
A
A
H
F
-------
E
A
M
M
D
-------
A
P
P
F
E
L
P
LPPMIR
A
E
Q
A
Q
P
V
A
L
A
M
A
G
H
L
L
W
M
-
E
R
A
-
A
R
G
R
F
K
V
C
R
T
A
A
E
V
R
S
C
H
A
D
G
I
V
S
G
I
M
H
M
E
G
A
E
A
I
G
A
D
L
D
A
L
H
L
F
H
S
L
G
L
R
S
L
G
P
V
W
---------
S
R
P
T
V
F
G
H
G
V
P
F
R
F
P
G
--
S
P
D
T
G
E
G
L
T
E
A
G
R
R
L
V
A
E
C
N
R
L
K
I
M
L
D
L
S
H
L
N
E
K
G
F
D
D
V
A
R
L
S
D
A
P
--
L
V
A
T
H
S
N
A
H
A
V
T
P
S
T
R
N
L
T
D
R
Q
L
A
M
I
R
E
S
R
G
M
V
G
L
-------------------------------
N
F
A
T
S
F
L
R
E
-
D
G
---------------------
R
----------------------------------------------------
R
S
A
E
-
M
G
W
E
P
V
L
R
H
L
D
H
L
I
D
R
L
G
E
D
H
V
G
M
G
S
D
F
D
G
A
T
-
I
-
P
Q
--
G
-
I
A
D
V
T
G
L
P
A
L
Q
A
A
M
R
A
H
G
Y
D
E
P
L
M
R
K
L
C
H
E
N
W
Y
G
L
L
E
R
----
24
HHSearch
76.30
24%
-18
- C2 -
-
3B40
-
?
A:
[12-409]
---
M
Q
H
A
E
E
L
H
E
R
I
L
S
F
D
S
R
I
--
T
--
V
P
L
D
F
G
T
T
G
N
E
V
---------
D
K
D
G
P
G
Q
L
D
L
V
K
A
G
R
G
R
L
S
G
A
A
L
-
A
I
F
G
W
P
E
M
W
-------------
P
H
K
P
T
-------
P
G
F
V
D
E
A
------
R
H
Q
Q
----
E
I
R
Y
K
-
I
L
T
G
M
V
R
D
-
F
P
N
Q
V
G
I
A
Y
S
P
E
D
F
R
R
L
A
M
E
G
K
F
A
I
V
M
S
M
L
N
A
Y
P
L
G
D
D
L
S
Q
L
D
K
W
A
A
R
G
V
R
M
F
G
F
S
Y
---------
V
G
N
N
D
W
A
D
S
S
R
P
L
P
F
F
ND
S
P
D
A
L
G
G
L
S
P
L
G
K
Q
A
V
E
R
L
N
D
L
G
V
I
I
D
V
S
Q
M
S
T
K
A
L
E
Q
V
A
A
L
S
R
A
P
--
I
V
A
S
H
S
A
P
R
A
L
V
D
I
K
R
N
L
S
D
H
E
M
Q
L
I
K
D
S
G
G
V
I
Q
V
-------------------------------
V
G
F
P
A
Y
L
R
P
-
L
S
---------------------
K
P
T
L
D
K
L
D
A
L
R
A
R
F
DLPPLEGLDYALMPGDPIITIWP
E
Q
R
F
G
E
Y
A
S
A
L
Y
G
I
L
E
E
E
P
K
-
A
G
L
K
E
L
V
D
A
I
D
Y
T
V
K
K
V
G
I
D
H
V
G
I
S
S
D
F
N
D
G
G
-
G
-
V
D
--
G
-
W
K
D
V
S
E
I
R
N
V
T
A
E
L
I
T
R
G
Y
S
D
A
D
I
A
K
L
W
G
G
N
F
L
R
A
W
G
E
V
Q
K
-
33
HHSearch
75.10
23%
-15
- C2 -
-
5NRY
-
?
A:
[19-358]
--
I
E
E
Q
A
T
R
L
L
K
E
V
P
L
I
D
G
H
N
--
D
--
F
P
Y
M
I
R
G
W
F
R
N
D
I
NGQ
D
A
H
L
-
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
G
L
L
G
G
Q
F
W
-
S
A
F
V
P
C
P
K
N
P
D
K
-----------
E
V
G
S
-------
L
E
A
L
R
Q
T
--------------
L
Q
Q
L
D
-
V
I
H
R
L
I
E
R
-
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
S
P
------
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
I
-------------------------------
C
F
L
R
E
L
L
A
S
-
E
A
---------------------
D
-------------------------------------------------------
Q
-
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
G
P
D
--
G
-
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
E
R
-
34
HHSearch
74.88
23%
-16
- C2 -
-
5NRT
-
?
A:
[19-358]
--
I
E
E
Q
A
T
R
L
L
K
E
V
P
L
I
D
G
H
N
--
D
--
F
P
Y
M
I
R
G
W
F
R
N
D
I
NGQ
D
A
H
L
-
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
G
L
L
G
G
Q
F
W
-
S
A
F
V
P
C
P
K
N
P
D
K
-----------
E
V
G
S
-------
L
E
A
L
R
Q
T
--------------
L
Q
Q
L
D
-
V
I
H
R
L
I
E
R
-
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
S
P
------
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
I
-------------------------------
C
F
L
R
E
L
L
A
S
-
E
A
---------------------
D
-------------------------------------------------------
Q
-
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
G
P
D
--
G
-
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
E
R
-
31
HHSearch
74.20
29%
-27
- C2 -
-
3NEH
1
?
A:
[2-310]
------------
S
L
R
V
I
D
T
H
C
--
D
--
A
L
Y
K
L
Q
A
G
K
G
K
Y
T
------
F
-
Q
D
A
E
E
L
D
V
N
F
E
R
L
I
E
A
K
M
L
L
Q
G
F
-
A
I
F
L
D
E
D
I
P
-----------------
V
-------
E
H
K
W
K
K
A
--------------
V
E
Q
V
N
-
I
F
K
Q
H
V
L
H
-
K
G
G
I
I
H
H
V
K
K
W
C
D
L
E
N
-
L
P
E
D
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
W
---------
N
N
A
N
L
A
A
D
G
I
M
E
--------
E
R
G
A
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
L
E
Q
A
-
E
F
--
V
I
A
S
H
S
N
A
K
A
I
C
S
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
-------------------------------
V
F
Y
P
L
F
T
T
N
-
N
G
-----------------------------------------------------------------------------
V
-
A
D
T
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
L
K
N
I
G
F
G
S
D
F
D
G
I
P
D
H
-
V
K
--
G
-
L
E
H
V
G
K
Y
Q
S
F
L
E
T
L
E
-
K
H
Y
T
K
E
E
I
E
G
F
A
S
R
N
F
L
N
H
L
P
K
----
16
PsiBlast_PDB
73.06
25%
-3
- C2 -
-
5LX4
4
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
H
F
P
--
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
25
HHSearch
72.89
22%
-12
- C2 -
-
2RAG
-
?
C:
[37-410]
---
S
K
A
D
K
A
L
H
D
K
F
L
T
L
D
T
H
L
--
D
--
T
P
A
H
F
G
R
P
G
W
D
I
A
---
D
H
H
E
-
V
E
H
D
F
S
Q
V
D
L
P
R
M
N
Q
G
G
L
D
G
G
F
F
-
V
V
Y
I
G
Q
G
E
L
T
E
-------------
K
G
Y
-------
T
Y
A
R
D
Y
A
--------------
L
H
R
T
I
-
E
I
R
E
M
L
A
A
-
N
P
D
T
F
E
M
A
L
T
S
D
D
A
R
R
I
A
K
A
G
K
K
F
A
F
V
S
M
E
N
S
W
P
V
G
E
D
L
S
L
V
E
T
F
Y
K
E
G
L
R
M
A
G
P
V
H
---------
F
R
N
N
Q
L
A
D
S
S
T
D
P
K
G
-----
K
I
W
N
G
Y
S
P
L
G
L
R
W
L
A
E
A
N
R
L
G
I
V
I
D
V
S
H
A
S
D
D
V
V
D
Q
S
V
A
L
S
K
A
P
--
I
I
A
S
H
S
G
P
K
A
V
Y
D
H
P
R
N
L
D
D
A
R
L
K
K
I
A
D
A
G
G
A
I
C
I
-------------------------------
N
S
I
Y
L
T
D
T
T
P
S
P
---------------------
E
APDMKTATPEAVKAYADKRAAIDKAH--------------------------
P
A
A
R
-
G
D
F
D
L
Y
M
K
S
M
L
H
V
L
K
V
A
G
P
K
G
V
C
V
G
A
D
W
D
G
G
G
-
G
-
M
D
--
G
-
F
E
D
I
T
D
L
P
K
I
T
A
R
L
K
A
E
G
Y
S
D
A
D
I
E
A
I
W
S
G
N
V
L
R
I
V
D
A
A
Q
A
-
8
PsiBlast_PDB
72.40
25%
-0
- C2 -
-
5NRY
-
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
5
PsiBlast_PDB
72.21
25%
-2
- C2 -
-
5NRT
-
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
11
PsiBlast_PDB
72.13
25%
-1
- C2 -
-
5NS2
1
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
10
PsiBlast_PDB
72.01
25%
1
- C2 -
-
5NS1
-
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
18
PsiBlast_PDB
71.94
23%
-7
- C2 -
-
3B40
-
?
A:
[48-407]
----------------------------------------------------
G
Q
L
D
L
V
K
A
G
R
G
R
L
S
G
A
A
L
-
A
I
F
G
W
P
E
M
W
--
P
H
K
P
-------
T
P
G
F
V
-------
D
E
A
R
H
--------
Q
Q
E
I
R
Y
K
I
L
T
G
M
-------
V
R
D
-
F
P
N
Q
V
G
I
A
Y
S
P
E
D
F
R
R
L
A
M
E
G
K
F
A
I
V
M
S
M
L
N
A
Y
P
L
G
D
D
L
S
Q
L
D
K
W
A
A
R
G
V
R
M
F
G
F
S
Y
VGNNDW
A
D
S
S
R
P
L
P
F
-------
F
N
D
--
S
P
D
A
L
G
G
L
S
P
L
G
K
Q
A
V
E
R
L
N
D
L
G
V
I
I
D
V
S
Q
M
S
T
K
A
L
E
Q
V
A
A
L
S
R
A
P
--
I
V
A
S
H
S
A
P
R
A
L
V
D
I
K
R
N
L
S
D
H
E
M
Q
L
I
K
D
S
G
G
V
I
Q
V
VGFPAYLRPLS
K
P
T
L
D
K
L
D
A
L
R
A
R
F
DLPPLE
G
L
D
Y
A
L
M
P
G
-
D
P
IITIWP
E
Q
R
F
G
E
Y
A
S
A
L
Y
G
I
L
E
----------------------------------------------------
E
E
P
K
-
A
G
L
K
E
L
V
D
A
I
D
Y
T
V
K
K
V
G
I
D
H
V
G
I
S
S
D
F
N
D
G
G
-
G
-
V
D
--
G
-
W
K
D
V
S
E
I
R
N
V
T
A
E
L
I
T
R
G
Y
S
D
A
D
I
A
K
L
W
G
G
N
F
L
R
A
W
G
E
V
---
9
PsiBlast_PDB
71.86
25%
-1
- C2 -
-
5NRZ
1
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
7
PsiBlast_PDB
71.69
25%
-0
- C2 -
-
5NRX
-
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
17
PsiBlast_PDB
71.66
25%
-5
- C2 -
-
5LX1
1
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
A
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
12
PsiBlast_PDB
71.63
25%
-2
- C2 -
-
5NS5
-
?
A:
[30-356]
-------------
V
P
L
I
D
G
H
N
--
D
F
P
Y
M
I
R
G
W
F
R
N
D
I
N
G
---
Q
D
A
H
L
Y
D
M
P
I
G
Q
T
D
L
Q
R
L
Q
K
-
G
L
L
G
G
Q
F
W
S
A
F
V
P
C
-----
P
K
N
P
-------
D
K
--------------
E
V
G
------
S
L
E
A
L
R
Q
T
L
Q
Q
L
D
-
V
I
H
R
-
L
I
E
R
H
P
T
I
L
Q
F
A
D
S
A
A
S
I
W
S
S
F
R
A
G
R
V
A
S
L
I
G
I
E
G
L
H
Q
I
A
D
S
V
S
A
L
R
M
L
H
R
L
G
V
R
Y
V
T
L
T
H
---------
N
C
H
N
A
F
A
D
A
A
T
V
------
S
P
E
L
H
G
G
L
S
R
K
G
E
R
L
I
R
E
L
N
R
M
G
M
M
I
D
L
S
H
T
S
H
E
A
Q
T
Q
A
L
R
L
S
R
A
P
--
V
I
Y
S
H
S
S
I
Y
S
L
R
A
H
A
R
N
V
T
D
E
N
L
H
L
L
H
R
N
R
G
V
V
M
-----------------------------------
I
C
F
L
R
E
-
L
L
---------------------
A
----------------------------------------------------
S
E
A
D
Q
A
T
L
A
H
V
I
D
H
I
I
Y
A
G
T
R
I
G
Y
E
H
V
G
I
G
S
D
F
D
G
M
L
-
R
-
G
P
--
D
G
L
H
D
V
S
C
Y
P
A
L
V
A
G
L
L
E
R
G
V
S
E
E
D
V
K
R
V
M
G
L
N
V
I
R
V
L
E
E
V
---
3
PsiBlast_PDB
61.15
32%
-24
- C2 -
-
3NEH
1
?
A:
[95-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
W
---------
N
N
A
N
L
A
A
D
G
I
--------
M
E
E
R
G
A
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
---
L
E
Q
A
EF
V
I
A
S
H
S
N
A
K
A
I
C
S
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
-------------------------------
V
F
Y
P
L
F
T
T
N
-
N
G
---------------------
V
----------------------------------------------------
A
D
T
-----
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
L
K
N
I
G
F
G
S
D
F
D
G
-
I
-
P
-
D
H
VK
G
-
L
E
H
V
G
K
Y
Q
S
F
L
E
T
L
E
K
-
H
Y
T
K
E
E
I
E
G
F
A
S
R
N
F
L
N
H
L
P
K
----
23
PsiBlast_CBE
60.06
32%
-22
- C2 -
-
3NEH
1
?
B:
[95-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
E
D
K
I
G
A
M
L
T
L
E
G
I
E
P
I
G
R
D
L
D
K
L
T
Q
L
L
D
G
G
V
L
S
V
G
L
T
W
---------
N
N
A
N
L
A
A
D
G
I
--------
M
E
E
R
G
A
G
L
T
R
F
G
K
D
I
I
H
L
L
N
E
R
K
V
F
T
D
V
S
H
L
S
V
K
A
F
W
E
T
---
L
E
Q
A
EF
V
I
A
S
H
S
N
A
K
A
I
C
S
H
P
R
N
L
D
D
E
Q
I
K
A
M
I
E
H
D
A
M
I
H
V
-------------------------------
V
F
Y
P
L
F
T
T
N
-
N
G
---------------------
V
----------------------------------------------------
A
D
T
-----
E
D
V
I
R
H
I
D
H
I
C
E
L
G
G
L
K
N
I
G
F
G
S
D
F
D
G
-
I
-
P
-
D
H
VK
G
-
L
E
H
V
G
K
Y
Q
S
F
L
E
T
L
E
K
-
H
Y
T
K
E
E
I
E
G
F
A
S
R
N
F
L
N
H
L
P
K
----