@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQE7: (2017-11-26 )
MYRTIETILVDIPTIRPHQLSVTTMRTQTLVLVKITTTDGIVGWGEATTIGGLNYGEESPESVKANIDTYFAPLLTSVKDLNVAQTLKLIRKNINGNRFAKCAIQTALLDIQAKRLGVPLSEVLGGRLRNSLPVLWTLASGDTEKDIAEARKMIELKRHNTFKLKIGARPLQQDVDHVIAIKKALGADVSVRVDVNRAWSELECIHGIQQLQDGGIDLIEQPCAIQNTEALARLTHRFDVAIMADEALTGPDSAYRIAKNHGADVFAVKIEQSGGLIEACEVGKIAGLAGIDLYGGTMLEGPVGSIASAHVFTTFETLAFGTELFGPLLLTEEILKGPLRYENFELHLPTAPGLGIEIDEDKIEKLRR
Atome Classification :
(20 SA)
-.........10........20........30........40........50........60........70........80........90.....--...100.......110.......120.......130.......140.......150.-.......160.......170.......180.......190.......200........210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340........350.......360......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MY
R
T
I
E
T
I
L
VDIPTIRP
H
Q
L
S
V
T
T
M
R
T
Q
T
L
V
L
V
K
I
TTTDGIVGWGE
A
T
T
IGGLNYGEES
P
E
S
V
K
A
N
I
D
T
Y
F
A
P
L
L
T
S
V
K
DL
N
V
A
Q
T
L
K
L
I
R
K
NING--
N
R
F
A
K
C
A
I
Q
T
A
L
L
D
I
Q
A
K
RLGV
P
L
S
E
V
L
G
G
R
L
RNSL
P
V
L
W
T
LASGD
T
E
K
D
I
A
E
A
-
R
K
-
M
I
E
LKRH
N
T
F
K
L
K
IGAR
P
L
Q
Q
D
V
D
H
V
I
A
I
K
K
A
LGA
D
V
S
V
R
V
D
V
N
R
A
W
S
E
-
L
E
C
I
H
G
I
Q
Q
L
QDGG
I
D
L
IEQPCAIQ
N
T
E
A
L
A
R
L
T
H
RF
D
V
A
I
M
ADEALTGP
D
S
A
Y
R
I
A
K
NHGA
D
V
F
A
V
K
I
EQSGG
L
I
E
A
CEVGKIAGL
A
G
I
DLYGGTMLEGPVGSIAS
A
H
V
F
T
T
F
E
T
L
A
F
G
T
E
L
F
G
P
L
L
L
T
E
E
I
L
KGPLR-YE
N
F
E
L
HLPTAPGL
G
I
EI
D
E
D
K
I
E
K
LRR
5
PsiBlast_PDB
94.36
53%
-93
- C1 -
-
3CT2
-
?
A:
[10-374]
----
S
I
E
T
I
I
V
D
L
P
T
I
-----------
N
Q
T
L
V
L
I
R
L
R
C
A
D
G
I
E
G
L
G
E
S
T
T
I
G
G
L
A
Y
G
N
E
S
P
D
S
I
K
T
N
I
D
R
F
V
A
P
L
L
I
G
Q
D
A
S
N
I
N
A
A
M
L
R
L
E
Q
S
I
R
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
A
L
P
V
A
W
T
L
A
S
G
D
T
A
K
D
I
A
E
A
-
Q
K
-
M
L
D
L
R
R
H
R
I
F
K
L
K
I
G
A
G
E
V
D
R
D
L
A
H
V
I
A
I
K
K
A
L
G
D
S
A
S
V
R
V
D
V
N
Q
A
W
D
E
-
A
V
A
L
R
A
C
R
I
L
G
G
N
G
I
D
L
I
E
Q
P
I
S
R
N
N
R
A
G
M
V
R
L
N
A
S
S
P
A
P
I
M
A
D
E
S
I
E
C
V
E
D
A
F
N
L
A
R
E
G
A
A
S
V
F
A
L
K
I
A
K
N
G
G
P
R
A
T
L
R
T
A
A
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
G
I
G
T
L
A
S
A
H
A
F
L
T
L
N
K
L
S
W
D
T
E
L
F
G
P
L
L
L
T
E
D
I
L
A
E
P
P
V
-
Y
R
D
F
H
L
H
V
S
K
A
P
G
L
G
L
S
L
D
E
E
R
L
A
F
F
R
R
1
PsiBlast_PDB
93.66
53%
-89
- C1 -
-
1MUC
-
CATB_PSEPU
A:
[9-372]
-----
I
D
A
I
I
V
D
L
P
T
I
R
---------
Q
Q
Q
T
L
V
V
L
R
V
R
C
S
D
G
V
E
G
I
G
E
A
T
T
I
G
G
L
A
Y
G
Y
E
S
P
E
G
I
K
A
N
I
D
A
H
L
A
P
A
L
I
G
L
A
A
D
N
I
N
A
A
M
L
K
L
D
K
L
A
K
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
S
L
E
V
A
W
T
L
A
S
G
D
T
A
R
D
I
A
E
A
-
R
H
-
M
L
E
I
R
R
H
R
V
F
K
L
K
I
G
A
N
P
V
E
Q
D
L
K
H
V
V
T
I
K
R
E
L
G
D
S
A
S
V
R
V
D
V
N
Q
Y
W
D
E
-
S
Q
A
I
R
A
C
Q
V
L
G
D
N
G
I
D
L
I
E
Q
P
I
S
R
I
N
R
G
G
Q
V
R
L
N
Q
R
T
P
A
P
I
M
A
D
E
S
I
E
S
V
E
D
A
F
S
L
A
A
D
G
A
A
S
I
F
A
L
K
I
A
K
N
G
G
P
R
A
V
L
R
T
A
Q
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
S
I
G
T
L
A
S
A
H
A
F
L
T
L
R
Q
L
T
W
G
T
E
L
F
G
P
L
L
L
T
E
E
I
V
N
E
P
P
Q
-
Y
R
D
F
Q
L
H
I
P
R
T
P
G
L
G
L
T
L
D
E
Q
R
L
A
R
F
A
R
3
PsiBlast_PDB
93.50
52%
-90
- C1 -
-
3MUC
-
CATB_PSEPU
A:
[6-369]
-----
I
D
A
I
I
V
D
L
P
T
I
R
---------
Q
Q
Q
T
L
V
V
L
R
V
R
C
S
D
G
V
E
G
I
G
E
A
T
T
V
G
G
L
A
Y
G
Y
E
S
P
E
G
I
K
A
N
I
D
A
H
L
A
P
A
L
I
G
L
A
A
D
N
I
N
A
A
M
L
K
L
D
K
L
A
K
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
S
L
E
V
A
W
T
L
A
S
G
D
T
A
R
D
I
A
E
A
-
R
H
-
M
L
E
I
R
R
H
R
V
F
K
L
K
I
G
A
N
P
V
E
Q
D
L
K
H
V
V
T
I
K
R
E
L
G
D
S
A
S
V
R
V
D
V
N
Q
Y
W
D
E
-
S
Q
A
I
R
A
C
Q
V
L
G
D
N
G
I
D
L
I
E
Q
P
I
S
R
I
N
R
G
G
Q
V
R
L
N
Q
R
T
P
A
P
I
M
A
D
E
S
I
E
S
V
E
D
A
F
S
L
A
A
D
G
A
A
S
I
F
A
L
K
I
A
K
N
G
G
P
R
A
V
L
R
T
A
Q
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
S
I
G
T
L
A
S
A
H
A
F
L
T
L
R
Q
L
T
W
G
T
E
L
F
G
P
L
L
L
T
E
E
I
V
N
E
P
P
Q
-
Y
R
D
F
Q
L
H
I
P
R
T
P
G
L
G
L
T
L
D
E
Q
R
L
A
R
F
A
R
24
PsiBlast_CBE
93.28
53%
-85
- C1 -
-
3FJ4
1
?
B:
[10-374]
----
S
I
E
T
I
I
V
D
L
P
T
I
R
P
H
K
L
A
M
H
T
M
Q
N
Q
T
L
V
L
I
R
L
R
C
A
D
G
I
E
G
L
G
E
S
T
T
I
G
G
L
A
Y
G
N
E
S
P
D
S
I
K
T
N
I
D
R
F
V
A
P
L
L
I
G
Q
D
A
S
N
I
N
A
A
M
L
R
L
E
Q
S
I
R
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
A
L
P
V
A
W
T
L
A
S
G
D
T
A
K
D
I
A
E
A
-
Q
K
-
M
L
D
L
R
R
H
R
I
F
K
L
K
I
G
A
G
E
V
D
R
D
L
A
H
V
I
A
I
K
K
A
L
G
D
S
A
S
V
R
V
D
V
N
Q
A
W
D
E
-
A
V
A
L
R
A
C
R
I
L
G
G
N
G
I
D
L
I
E
Q
P
I
S
R
N
N
R
A
G
M
V
R
L
N
A
S
S
P
A
P
I
M
A
D
E
S
I
E
C
V
E
D
A
F
N
L
A
R
E
G
A
A
S
V
F
A
L
K
I
A
K
N
G
G
P
R
A
T
L
R
T
A
A
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
G
I
G
T
L
A
S
A
H
A
F
L
T
L
N
K
L
S
W
D
T
E
L
F
G
P
L
L
L
T
E
D
I
L
A
E
P
P
V
-
Y
R
D
F
H
L
H
V
S
K
A
P
G
L
G
L
S
L
D
E
E
R
L
A
F
F
R
R
50
HHSearch
92.66
53%
-84
- C1 -
-
3DGB
1
?
A:
[7-373]
-
A
I
E
S
I
E
T
I
I
V
D
L
P
T
I
R
P
H
K
L
A
M
H
T
M
Q
N
Q
T
L
V
L
I
R
L
R
C
A
D
G
I
E
G
L
G
E
S
T
T
I
G
G
L
A
Y
G
N
E
S
P
D
S
I
K
T
N
I
D
R
F
V
A
P
L
L
I
G
Q
D
A
S
N
I
N
A
A
M
L
R
L
E
Q
S
I
R
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
A
L
P
V
A
W
T
L
A
S
G
D
T
A
K
D
I
A
E
A
-
Q
K
-
M
L
D
L
R
R
H
R
I
F
K
L
K
I
G
A
G
E
V
D
R
D
L
A
H
V
I
A
I
K
K
A
L
G
D
S
A
S
V
R
V
D
V
N
Q
A
W
D
E
-
A
V
A
L
R
A
C
R
I
L
G
G
N
G
I
D
L
I
E
Q
P
I
S
R
N
N
R
A
G
M
V
R
L
N
A
S
S
P
A
P
I
M
A
D
E
S
I
E
C
V
E
D
A
F
N
L
A
R
E
G
A
A
S
V
F
A
L
K
I
A
K
N
G
G
P
R
A
T
L
R
T
A
A
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
G
I
G
T
L
A
S
A
H
A
F
L
T
L
N
K
L
S
W
D
T
E
L
F
G
P
L
L
L
T
E
D
I
L
A
E
P
P
V
-
Y
R
D
F
H
L
H
V
S
K
A
P
G
L
G
L
S
L
D
E
E
R
L
A
F
F
R
-
4
PsiBlast_PDB
92.46
52%
-88
- C1 -
-
2MUC
-
CATB_PSEPU
A:
[9-372]
-----
I
D
A
I
I
V
D
L
P
T
I
R
---------
Q
Q
Q
T
L
V
V
L
R
V
R
C
S
D
G
V
E
G
I
G
E
A
T
T
I
G
G
L
A
Y
G
Y
E
S
P
E
G
I
K
A
N
I
D
A
H
L
A
P
A
L
I
G
L
A
A
D
N
I
N
A
A
M
L
K
L
D
K
L
A
K
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
S
L
E
V
A
W
T
L
A
S
G
D
T
A
R
D
I
A
E
A
-
R
H
-
M
L
E
I
R
R
H
R
V
F
K
L
K
I
G
A
N
P
V
E
Q
D
L
K
H
V
V
T
I
K
R
E
L
G
D
S
A
S
V
R
V
D
V
N
Q
Y
W
D
E
-
S
Q
A
I
R
A
C
Q
V
L
G
D
N
G
I
D
L
I
E
Q
P
I
S
R
I
N
R
G
G
Q
V
R
L
N
Q
R
T
P
A
P
I
M
A
D
E
S
I
E
S
V
E
D
A
F
S
L
A
A
D
G
A
A
S
I
F
A
L
K
I
A
K
N
G
G
P
R
A
V
L
R
T
A
Q
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
S
I
G
T
L
A
S
A
H
A
F
L
T
L
R
Q
L
T
W
G
T
E
L
I
G
P
L
L
L
T
E
E
I
V
N
E
P
P
Q
-
Y
R
D
F
Q
L
H
I
P
R
T
P
G
L
G
L
T
L
D
E
Q
R
L
A
R
F
A
R
6
PsiBlast_PDB
91.50
53%
-82
- C1 -
-
3DGB
1
?
A:
[10-374]
----
S
I
E
T
I
I
V
D
L
P
T
I
R
P
H
K
L
A
M
H
T
M
Q
N
Q
T
L
V
L
I
R
L
R
C
A
D
G
I
E
G
L
G
E
S
T
T
I
G
G
L
A
Y
G
N
E
S
P
D
S
I
K
T
N
I
D
R
F
V
A
P
L
L
I
G
Q
D
A
S
N
I
N
A
A
M
L
R
L
E
Q
S
I
R
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
A
L
P
V
A
W
T
L
A
S
G
D
T
A
K
D
I
A
E
A
-
Q
K
-
M
L
D
L
R
R
H
R
I
F
K
L
K
I
G
A
G
E
V
D
R
D
L
A
H
V
I
A
I
K
K
A
L
G
D
S
A
S
V
R
V
D
V
N
Q
A
W
D
E
-
A
V
A
L
R
A
C
R
I
L
G
G
N
G
I
D
L
I
E
Q
P
I
S
R
N
N
R
A
G
M
V
R
L
N
A
S
S
P
A
P
I
M
A
D
E
S
I
E
C
V
E
D
A
F
N
L
A
R
E
G
A
A
S
V
F
A
L
K
I
A
K
N
G
G
P
R
A
T
L
R
T
A
A
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
G
I
G
T
L
A
S
A
H
A
F
L
T
L
N
K
L
S
W
D
T
E
L
F
G
P
L
L
L
T
E
D
I
L
A
E
P
P
V
-
Y
R
D
F
H
L
H
V
S
K
A
P
G
L
G
L
S
L
D
E
E
R
L
A
F
F
R
R
2
PsiBlast_PDB
91.26
53%
-88
- C1 -
-
1BKH
-
?
A:
[9-372]
-----
I
D
A
I
I
V
D
L
P
T
I
-----------
Q
Q
T
L
V
V
L
R
V
R
C
S
D
G
V
E
G
I
G
E
A
T
T
I
G
G
L
A
Y
G
Y
E
S
P
E
G
I
K
A
N
I
D
A
H
L
A
P
A
L
I
G
L
A
A
D
N
I
N
A
A
M
L
K
L
D
K
L
A
K
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
S
L
E
V
A
W
T
L
A
S
G
D
T
A
R
D
I
A
E
A
-
R
H
-
M
L
E
I
R
R
H
R
V
F
K
L
K
I
G
A
N
P
V
E
Q
D
L
K
H
V
V
T
I
K
R
E
L
G
D
S
A
S
V
R
V
D
V
N
Q
Y
W
D
E
-
S
Q
A
I
R
A
C
Q
V
L
G
D
N
G
I
D
L
I
E
Q
P
I
S
R
I
N
R
G
G
Q
V
R
L
N
Q
R
T
P
A
P
I
M
A
D
E
S
I
E
S
V
E
D
A
F
S
L
A
A
D
G
A
A
S
I
F
A
L
K
I
A
K
N
G
G
P
R
A
V
L
R
T
A
Q
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
S
I
G
T
L
A
S
A
H
A
F
L
T
L
R
Q
L
T
W
G
T
E
L
F
G
P
L
L
L
T
E
E
I
V
N
E
P
P
Q
-
Y
R
D
F
Q
L
H
I
P
R
T
P
G
L
G
L
T
L
D
E
Q
R
L
A
R
F
A
R
7
PsiBlast_PDB
91.23
53%
-84
- C1 -
-
3FJ4
1
?
A:
[10-374]
----
S
I
E
T
I
I
V
D
L
P
T
I
R
P
H
K
L
A
M
H
T
M
Q
N
Q
T
L
V
L
I
R
L
R
C
A
D
G
I
E
G
L
G
E
S
T
T
I
G
G
L
A
Y
G
N
E
S
P
D
S
I
K
T
N
I
D
R
F
V
A
P
L
L
I
G
Q
D
A
S
N
I
N
A
A
M
L
R
L
E
Q
S
I
R
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
A
L
P
V
A
W
T
L
A
S
G
D
T
A
K
D
I
A
E
A
-
Q
K
-
M
L
D
L
R
R
H
R
I
F
K
L
K
I
G
A
G
E
V
D
R
D
L
A
H
V
I
A
I
K
K
A
L
G
D
S
A
S
V
R
V
D
V
N
Q
A
W
D
E
-
A
V
A
L
R
A
C
R
I
L
G
G
N
G
I
D
L
I
E
Q
P
I
S
R
N
N
R
A
G
M
V
R
L
N
A
S
S
P
A
P
I
M
A
D
E
S
I
E
C
V
E
D
A
F
N
L
A
R
E
G
A
A
S
V
F
A
L
K
I
A
K
N
G
G
P
R
A
T
L
R
T
A
A
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
G
I
G
T
L
A
S
A
H
A
F
L
T
L
N
K
L
S
W
D
T
E
L
F
G
P
L
L
L
T
E
D
I
L
A
E
P
P
V
-
Y
R
D
F
H
L
H
V
S
K
A
P
G
L
G
L
S
L
D
E
E
R
L
A
F
F
R
R
8
PsiBlast_PDB
90.21
42%
-97
- C1 -
-
1NU5
-
TCBD_PSESQ
A:
[6-368]
-----
I
S
T
T
I
V
D
V
P
T
R
R
P
L
Q
M
S
F
T
T
V
H
K
Q
S
Y
V
I
V
Q
V
K
A
G
G
L
V
G
I
-
G
E
G
G
S
V
G
G
P
T
W
G
S
E
S
A
E
T
I
K
V
I
I
D
N
Y
L
A
P
L
L
V
G
K
D
A
S
N
L
S
Q
A
R
V
L
M
D
R
A
V
T
G
--
N
L
S
A
K
A
A
I
D
I
A
L
H
D
L
K
A
R
A
L
N
L
S
I
A
D
L
I
G
G
T
M
R
T
S
I
P
I
A
W
T
L
A
S
G
D
T
A
R
D
I
D
S
A
-
L
E
-
M
I
E
T
R
R
H
N
R
F
K
V
K
L
G
A
R
T
P
A
Q
D
L
E
H
I
R
S
I
V
K
A
V
G
D
R
A
S
V
R
V
D
V
N
Q
G
W
D
E
-
Q
T
A
S
I
W
I
P
R
L
E
E
A
G
V
E
L
V
E
Q
P
V
P
R
A
N
F
G
A
L
R
R
L
T
E
Q
N
G
V
A
I
L
A
D
E
S
L
S
S
L
S
S
A
F
E
L
A
R
D
H
A
V
D
A
F
S
L
K
L
C
N
M
G
G
I
A
N
T
L
K
V
A
A
V
A
E
A
A
G
I
S
S
Y
G
G
T
M
L
D
S
T
V
G
T
A
A
A
L
H
V
Y
A
T
L
P
S
L
P
Y
G
C
E
L
I
G
P
W
V
L
G
D
R
L
T
Q
Q
D
L
E
-
I
K
D
F
E
V
H
L
P
L
G
S
G
L
G
V
D
L
D
H
D
K
V
R
H
Y
T
R
9
PsiBlast_PDB
84.66
41%
-102
- C1 -
-
2CHR
-
TFDD1_CUPNJ
A:
[6-368]
-----
I
E
A
V
I
V
D
V
P
T
K
R
P
I
Q
M
S
I
T
T
V
H
Q
Q
S
Y
V
I
V
R
V
Y
S
-
E
G
L
V
G
V
G
E
G
G
S
V
G
G
P
V
W
S
A
E
C
A
E
T
I
K
I
I
V
E
R
Y
L
A
P
H
L
L
G
T
D
A
F
N
V
S
G
A
L
Q
T
M
A
R
A
V
T
G
--
N
A
S
A
K
A
A
V
E
M
A
L
L
D
L
K
A
R
A
L
G
V
S
I
A
E
L
L
G
G
P
L
R
S
A
I
P
I
A
W
T
L
A
S
G
D
T
K
R
D
L
D
S
A
-
V
E
-
M
I
E
R
R
R
H
N
R
F
K
V
K
L
G
F
R
S
P
Q
D
D
L
I
H
M
E
A
L
S
N
S
L
G
S
K
A
Y
L
R
V
D
V
N
Q
A
W
D
E
-
Q
V
A
S
V
Y
I
P
E
L
E
A
L
G
V
E
L
I
E
Q
P
V
G
R
E
N
T
Q
A
L
R
R
L
S
D
N
N
R
V
A
I
M
A
D
E
S
L
S
T
L
A
S
A
F
D
L
A
R
D
R
S
V
D
V
F
S
L
K
L
C
N
M
G
G
V
S
A
T
Q
K
I
A
A
V
A
E
A
S
G
I
A
S
Y
G
G
T
M
L
D
S
T
I
G
T
S
V
A
L
Q
L
Y
S
T
V
P
S
L
P
F
G
C
E
L
I
G
P
F
V
L
A
D
T
L
S
H
E
P
L
E
-
I
R
D
Y
E
L
Q
V
P
T
G
V
G
H
G
M
T
L
D
E
D
K
V
R
Q
Y
A
R
48
HHSearch
84.28
52%
-29
- C1 -
-
1BKH
-
?
B:
[5-372]
-
L
I
E
R
I
D
A
I
I
V
D
L
P
T
I
R
P
--------
Q
Q
Q
T
L
V
V
L
R
V
R
C
S
D
G
V
E
G
I
G
E
A
T
T
I
G
G
L
A
Y
G
Y
E
S
P
E
G
I
K
A
N
I
D
A
H
L
A
P
A
L
I
G
L
A
A
D
N
I
N
A
A
M
L
K
L
D
K
L
A
K
G
--
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
P
V
S
E
L
L
G
G
R
V
R
D
S
L
E
V
A
W
T
L
A
S
G
D
T
A
R
D
I
A
E
A
-
R
H
M
L
E
-
I
R
R
H
R
V
F
K
L
K
I
G
A
N
P
V
E
Q
D
L
K
H
V
V
T
I
K
R
E
L
G
D
S
A
S
V
R
V
D
V
N
Q
Y
W
D
E
-
S
Q
A
I
R
A
C
Q
V
L
G
D
N
G
I
D
L
I
E
Q
P
I
S
R
I
N
R
G
G
Q
V
R
L
N
Q
R
T
P
A
P
I
M
A
D
E
S
I
E
S
V
E
D
A
F
S
L
A
A
D
G
A
A
S
I
F
A
L
K
I
A
K
N
G
G
P
R
A
V
L
R
T
A
Q
I
A
E
A
A
G
I
G
L
Y
G
G
T
M
L
E
G
S
I
G
T
L
A
S
A
H
A
F
L
T
L
R
Q
L
T
W
G
T
E
L
F
G
P
L
L
L
T
E
E
I
V
N
E
P
P
Q
-
Y
R
D
F
Q
L
H
I
P
R
T
P
G
L
G
L
T
L
D
E
Q
R
L
A
R
F
A
R
11
PsiBlast_PDB
82.34
33%
-84
- C1 -
-
3I4K
1
?
A:
[9-374]
---
Q
K
V
E
S
R
I
L
D
V
P
L
I
R
P
H
G
F
A
T
T
T
S
T
E
Q
H
I
L
L
V
S
V
H
L
E
N
G
V
I
G
Y
G
E
G
V
V
P
G
G
P
W
W
G
G
E
S
V
E
T
M
K
A
L
V
D
G
Y
L
A
P
V
L
I
G
R
A
V
S
E
L
A
G
I
M
A
D
L
E
R
V
V
A
R
--
A
R
Y
A
K
A
A
V
D
V
A
M
H
D
A
W
A
R
S
L
N
V
P
V
R
D
L
L
G
G
T
V
R
D
K
V
D
V
T
W
A
L
G
V
L
P
L
D
V
A
V
A
E
I
-
E
E
-
R
I
E
E
F
G
N
R
S
F
K
L
K
M
G
A
G
D
P
A
E
D
T
R
R
V
A
E
L
A
R
E
V
G
D
R
V
S
L
R
I
D
I
N
A
R
W
D
R
-
R
T
A
L
H
Y
L
P
I
L
A
E
A
G
V
E
L
F
E
Q
P
T
P
A
D
D
L
E
T
L
R
E
I
T
R
R
T
N
V
S
V
M
A
D
E
S
V
W
T
P
A
E
A
L
A
V
V
K
A
Q
A
A
D
V
I
A
L
K
T
T
K
H
G
G
L
L
E
S
K
K
I
A
A
I
A
E
A
G
G
L
A
C
H
G
A
T
S
L
E
G
P
I
G
T
A
A
S
L
Q
F
A
A
S
T
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A
I
S
Y
G
T
E
L
F
G
P
Q
L
L
K
D
T
Y
I
V
Q
E
F
E
-
Y
K
D
G
Q
V
A
I
P
Q
G
P
G
L
G
V
D
V
D
M
D
K
V
N
F
Y
T
R
53
HHSearch
81.45
34%
-92
- C1 -
-
3I4K
1
?
H:
[7-373]
-
T
I
Q
K
V
E
S
R
I
L
D
V
P
L
I
R
P
H
G
F
A
T
T
T
S
T
E
Q
H
I
L
L
V
S
V
H
L
E
N
G
V
I
G
Y
G
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G
V
V
P
G
G
P
W
W
G
G
E
S
V
E
T
M
K
A
L
V
D
G
Y
L
A
P
V
L
I
G
R
A
V
S
E
L
A
G
I
M
A
D
L
E
R
V
V
A
R
--
A
R
Y
A
K
A
A
V
D
V
A
M
H
D
A
W
A
R
S
L
N
V
P
V
R
D
L
L
G
G
T
V
R
D
K
V
D
V
T
W
A
L
G
V
L
P
L
D
V
A
V
A
E
I
-
E
E
-
R
I
E
E
F
G
N
R
S
F
K
L
K
M
G
A
G
D
P
A
E
D
T
R
R
V
A
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L
A
R
E
V
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D
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V
S
L
R
I
D
I
N
A
R
W
D
R
-
R
T
A
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Y
L
P
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A
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A
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D
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T
R
R
T
N
V
S
V
M
A
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S
V
W
T
P
A
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A
L
A
V
V
K
A
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A
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V
I
A
L
K
T
T
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G
G
L
L
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S
K
K
I
A
A
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A
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A
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G
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A
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H
G
A
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A
A
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Y
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-
Y
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I
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Q
G
P
G
L
G
V
D
V
D
M
D
K
V
N
F
Y
T
-
47
HHSearch
79.78
37%
-88
- C1 -
-
4M0X
-
?
A:
[4-369]
-
T
I
T
E
M
S
A
T
I
V
D
L
P
S
R
R
P
H
K
F
A
A
T
T
M
H
H
Q
S
I
V
L
V
R
V
R
D
S
D
G
G
E
G
I
G
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A
V
T
P
G
G
P
W
W
G
G
E
S
V
E
T
I
K
T
I
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D
Q
Y
L
A
P
V
I
I
G
R
D
P
S
T
I
G
V
A
S
Q
S
M
D
G
L
V
F
G
--
N
S
V
A
K
A
A
I
E
T
A
L
W
D
D
R
E
R
R
S
R
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V
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D
L
L
G
G
L
R
R
K
R
I
P
I
T
W
A
F
S
A
G
S
A
S
D
L
I
D
E
A
-
A
Q
-
K
L
-
D
V
G
H
R
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F
K
F
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M
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A
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A
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R
V
L
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L
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C
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A
V
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N
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-
L
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N
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G
L
A
R
L
R
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K
L
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I
M
A
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V
T
T
V
Q
Q
A
I
A
L
A
D
A
G
A
V
S
A
F
A
I
K
I
P
K
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G
G
L
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A
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A
A
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A
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L
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G
A
A
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M
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A
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A
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Y
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V
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-
Y
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L
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G
P
G
S
G
V
N
L
D
E
E
R
L
R
K
Y
S
-
57
HHSearch
79.14
42%
-36
- C1 -
-
1NU5
-
TCBD_PSESQ
A:
[2-367]
-
K
I
E
A
I
S
T
T
I
V
D
V
P
T
R
R
P
L
Q
M
S
F
T
T
V
H
K
Q
S
Y
V
I
V
Q
V
K
A
-
G
G
L
V
G
I
G
E
G
G
S
V
G
G
P
T
W
G
S
E
S
A
E
T
I
K
V
I
I
D
N
Y
L
A
P
L
L
V
G
K
D
A
S
N
L
S
Q
A
R
V
L
M
D
R
A
V
T
G
--
N
L
S
A
K
A
A
I
D
I
A
L
H
D
L
K
A
R
A
L
N
L
S
I
A
D
L
I
G
G
T
M
R
T
S
I
P
I
A
W
T
L
A
S
G
D
T
A
R
D
I
D
S
A
L
E
M
-
I
E
-
T
R
R
H
N
R
F
K
V
K
L
G
A
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T
P
A
Q
D
L
E
H
I
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S
I
V
K
A
V
G
D
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A
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V
R
V
D
V
N
Q
G
W
D
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-
Q
T
A
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I
W
I
P
R
L
E
E
A
G
V
E
L
V
E
Q
P
V
P
R
A
N
F
G
A
L
R
R
L
T
E
Q
N
G
V
A
I
L
A
D
E
S
L
S
S
L
S
S
A
F
E
L
A
R
D
H
A
V
D
A
F
S
L
K
L
C
N
M
G
G
I
A
N
T
L
K
V
A
A
V
A
E
A
A
G
I
S
S
Y
G
G
T
M
L
D
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T
V
G
T
A
A
A
L
H
V
Y
A
T
L
P
S
L
P
Y
G
C
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L
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P
W
V
L
G
D
R
L
T
Q
Q
D
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-
I
K
D
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H
L
P
L
G
S
G
L
G
V
D
L
D
H
D
K
V
R
H
Y
T
-
10
PsiBlast_PDB
78.88
37%
-88
- C1 -
-
4M0X
-
?
A:
[8-370]
-----
M
S
A
T
I
V
D
L
P
S
R
R
P
H
K
F
A
A
T
T
M
H
H
Q
S
I
V
L
V
R
V
R
D
S
D
G
G
E
G
I
G
E
A
V
T
P
G
G
P
W
W
G
G
E
S
V
E
T
I
K
T
I
I
D
Q
Y
L
A
P
V
I
I
G
R
D
P
S
T
I
G
V
A
S
Q
S
M
D
G
L
V
F
G
--
N
S
V
A
K
A
A
I
E
T
A
L
W
D
D
R
E
R
R
S
R
I
P
V
S
D
L
L
G
G
L
R
R
K
R
I
P
I
T
W
A
F
S
A
G
S
A
S
D
L
I
D
E
A
-
A
Q
-
K
L
D
V
G
-
H
R
S
F
K
F
K
M
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A
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P
A
D
T
D
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R
R
V
L
D
V
L
E
C
I
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D
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C
A
V
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V
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P
N
G
R
W
S
E
-
L
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A
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W
L
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A
D
A
G
V
T
V
A
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P
I
A
R
W
N
T
D
G
L
A
R
L
R
D
K
L
S
I
P
I
M
A
D
E
S
V
T
T
V
Q
Q
A
I
A
L
A
D
A
G
A
V
S
A
F
A
I
K
I
P
K
S
G
G
L
S
R
A
R
E
I
A
A
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A
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A
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G
L
A
C
F
G
A
A
T
P
E
S
S
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M
G
A
I
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A
Q
L
Y
G
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D
L
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G
L
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V
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-
Y
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L
L
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T
G
P
G
S
G
V
N
L
D
E
E
R
L
R
K
Y
S
R
37
Fugue
77.42
52%
16
- C1 -
-
1MUC
-
CATB_PSEPU
A:
[4-372]
A
L
I
E
R
I
D
A
I
I
V
D
L
P
T
I
R
---------
Q
Q
Q
T
L
V
V
L
R
V
R
C
S
D
G
V
E
G
I
G
E
A
T
T
I
G
G
L
A
Y
G
Y
E
S
P
E
G
I
K
A
N
I
D
A
H
L
A
P
A
L
I
G
L
A
A
D
N
I
N
A
A
M
L
K
L
D
K
L
A
--KG
N
T
F
A
K
S
G
I
E
S
A
L
L
D
A
Q
G
K
R
L
G
L
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V
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L
L
G
G
R
V
R
D
S
L
E
V
A
W
T
L
A
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G
D
T
A
R
D
I
A
E
A
-
R
H
-
M
L
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R
R
H
R
V
F
K
L
K
I
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A
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R
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L
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D
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A
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V
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N
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Y
W
D
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-
S
Q
A
I
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A
C
Q
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L
G
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G
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L
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Q
P
I
S
R
I
N
R
G
G
Q
V
R
L
N
Q
R
T
P
A
P
I
M
A
D
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I
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V
E
D
A
F
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L
A
A
D
G
A
A
S
I
F
A
L
K
I
A
K
N
G
G
P
R
A
V
L
R
T
A
Q
I
A
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A
A
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I
G
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Y
G
G
T
M
L
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G
T
L
A
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A
H
A
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L
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Q
L
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G
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Y
R
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G
L
G
L
T
L
D
E
Q
R
L
A
R
F
A
R
58
HHSearch
74.99
25%
-87
- C1 -
-
3Q45
-
AAEP_CYTH3
G:
[2-363]
-
I
I
T
Q
V
E
L
Y
K
S
P
V
K
L
K
E
P
F
K
I
S
L
G
I
L
T
H
A
N
N
V
I
V
R
I
H
T
A
S
G
H
I
G
Y
G
E
C
S
P
F
M
T
--
I
H
G
E
S
M
D
T
A
F
-
I
V
G
Q
Y
L
A
K
G
L
I
G
T
S
C
L
D
I
V
S
N
S
L
L
M
D
A
I
I
Y
G
--
N
S
C
I
K
S
A
F
N
I
A
L
Y
D
L
A
A
Q
H
A
G
L
P
L
Y
A
F
L
G
G
K
K
D
K
I
I
Q
T
D
Y
T
V
S
I
D
E
P
H
K
M
A
A
D
A
-
V
Q
-
I
K
-
K
N
G
F
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I
I
K
V
K
V
G
G
S
-
K
E
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E
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I
R
M
I
R
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A
A
G
D
S
I
T
L
R
I
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A
N
Q
G
W
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V
-
E
T
A
I
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L
T
L
L
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P
Y
N
I
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C
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P
V
S
R
N
L
Y
T
A
L
P
K
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A
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R
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P
I
M
A
D
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C
C
N
S
F
D
A
E
R
L
I
Q
I
Q
A
C
D
S
F
N
L
K
L
S
K
S
A
G
I
T
N
A
L
N
I
I
R
L
A
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Q
A
H
M
P
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Q
V
G
G
F
L
E
S
R
L
G
F
T
A
A
A
H
V
A
L
V
S
K
T
I
C
Y
-
Y
D
F
D
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L
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G
G
I
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Q
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T
A
G
L
G
A
G
Y
Q
K
D
Y
L
S
G
L
E
-
51
HHSearch
74.38
32%
-39
* C1 *
-
2P8B
1
NSAR_BACCR
A:
[2-362]
-
K
I
T
A
I
H
L
Y
A
I
R
L
P
L
R
N
P
F
V
I
S
Y
G
S
Y
S
D
M
P
S
I
I
V
K
M
E
T
D
E
G
I
I
G
Y
G
E
G
V
A
D
D
H
--
V
T
G
E
S
W
E
S
T
F
H
T
L
K
H
T
L
T
P
A
L
I
G
Q
N
P
M
N
I
E
K
I
H
D
M
M
D
N
T
I
Y
G
--
V
P
T
A
K
A
A
I
D
I
A
C
F
D
I
M
G
K
K
L
N
Q
P
V
Y
Q
L
I
G
G
R
Y
H
E
E
F
P
V
T
H
V
L
S
I
A
D
P
E
N
M
A
E
E
A
-
A
S
-
M
I
-
Q
K
G
Y
Q
S
F
K
M
K
V
G
T
N
-
V
K
E
D
V
K
R
I
E
A
V
R
E
R
V
G
N
D
I
A
I
R
V
D
V
N
Q
G
W
K
N
S
A
N
T
L
T
A
L
R
S
L
G
H
L
N
I
D
W
I
E
Q
P
V
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A
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D
I
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A
M
A
H
I
R
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K
T
D
L
P
L
M
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L
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S
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R
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