@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQI6: (2017-11-27 )
MTHFIFVTGGVVSSLGKGISAASVAALLEARGLKVTMVKMDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGYYERFLRRAKMTKLNNFTSGRVYQDVLNKERRGDYLGGTVQVIPHITDNIKERVLRAGEGYDVAIVEIGGTVGDIESLPFMESVRQLMVELGHKRTMLMHLTLLPYIKSAAELKTKPTQHSVKELLSIGIQPDILICRTEYDVDADTKRKIALFTNVEARAVVVCKDAKTIYQIPRGFYEQNVDDLICERFGFTDLPEADLTDWDNVVEALLNPEYTVRVAMVGKYVELPDAYKSVNEALLHAGIKNRVKVQIDYVNAEELESQDVSILKTADAILVPGGFGERGTEGKMKAIQYARENGIPFLGICLGMQLAVIEYARHVAGMPEASSTEFNRSTKYPLIGLITEWLDERGELQQRSLESDLGGTMRLGAQKSELVEGTKTREVYGKAEITERHRHRYEMNNRFIEAIEQAGMKISGYSSAQHLVETVEIPEHPWFIAVQFHPEFTSSPRDGHPLFASFIDAAKTQHQKSK
Atome Classification :
(20 SA)
.-........10........20........30........40........50........60........70........80........90........100.......110.......120.......130------.--------.--.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.....--.--.270.........280..--.--....290.......300-........310.......320.......330--...---...-----------.340-.--------....----....350.......360.......370.......380.......390.......400.......410.......420.......430...---....440.......-450...-.....460.-.-.....470.......480-.......490.----.----.....500...--.--...510.......520.......530.......540...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M-
T
H
F
I
F
VT
G
G
V
V
S
S
L
GKG
I
S
A
A
S
V
A
A
L
L
E
ARG
L
K
V
T
M
V
K
MD
P
Y
I
N
VDPGTMSPFQHG
E
V
F
V
TEDGAETDL
D
L
G
Y
Y
E
R
F
L
R
R
A
K
M
T
KLNNFTS
G
R
V
Y
Q
D
V
L
N
K
E
RRGDYLG
G
T
V
Q
VIPH
I
T
D
N
I
K
E
R
V
L
RA--------G--------E--G
Y
D
V
A
I
V
E
IGGTVGDIESL
P
F
M
E
S
V
R
Q
L
M
V
ELGHK
R
T
M
L
M
H
L
T
L
L
P
Y
I
K
S
A
A
ELKTKP
T
Q
H
S
V
K
E
L
L
SIGIQP
D
I
L
I
C
RTEYDVDADT
K
R
K
I
A
L
F
TNV
E
A
R
A
V
V
V
CKD
A
K
T
I
Y
QI
P
R
G
F
Y
EQ
N
V
D
D
L
I
C
E
RFGFT--D--LP--EADLT
D
W
D
N
V
V
E
A
L--L--NP
E
Y
T
V
R
V
A
M
VGKYV-E-L
P
D
A
Y
K
S
V
N
E
A
L
L
H
AGIK
N
R
V
K
V
Q
I
D
YV
N
A
E
--
E
LE---SQD-----------V
S
---
I
--------
L
KTA----
D
A
I
L
VPGGFGERGTEG
K
M
K
A
I
Q
Y
A
R
ENGIP
F
L
G
I
C
L
G
M
Q
L
A
V
I
E
Y
A
R
H
VAGMPEASSTEFNRSTKY
P
L
I
G
L
I
T
E
W
L
D
E
RG
E
L
Q
Q
R
S
L
E
S
D---LGG
T
M
RLGA
Q
K
S
E
L
-VE-GTK-T
R
E
V
YGK
A
E
-
I
-
T
E
R
H
R
H
R
Y
E
M
N
N
R
F
I
E
A
I
-
E
QAG
M
K
ISGY
S
----
S
----
A
Q
H
L
V
E
T
VEIP--E--HP
W
F
I
A
V
Q
FHPEFTSSPRDG
H
P
L
F
A
S
F
I
D
A
A
K
T
QHQKSK
23
PsiBlast_CBE
98.62
63%
-98
- C3 -
-
5TKV
7
PYRG_ECOLI
B:
[23-563]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
-
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
--------
G
--------
E
--
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
---
N
--
A
P
--
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
-
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
--
D
V
E
---
T
R
G
-----------
V
E
---
I
--------
L
K
G
L
----
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
N
V
E
V
------------
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
D
-
D
S
L
-
V
R
Q
L
Y
N
A
P
T
-
I
-
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
-
E
D
A
G
L
R
V
A
G
R
S
----
G
----
D
D
Q
L
V
E
I
I
E
V
P
--
N
--
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
-
S
E
F
Q
K
R
Q
21
PsiBlast_CBE
98.12
63%
-94
- C3 -
-
2AD5
4
PYRG_ECOLI
B:
[3-543]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
-
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
--------
G
--------
E
--
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
---
N
--
C
P
--
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
-
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
--
D
V
E
---
T
R
G
-----------
V
E
---
I
--------
L
K
G
L
----
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
N
V
E
V
------------
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
D
-
D
S
L
-
V
R
Q
L
Y
N
A
P
T
-
I
-
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
-
E
D
A
G
L
R
V
A
G
R
S
----
G
----
D
D
Q
L
V
E
I
I
E
V
P
--
N
--
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
-
S
E
F
Q
K
R
Q
44
HHSearch
97.68
63%
-92
- C3 -
-
2AD5
4
PYRG_ECOLI
B:
[2-544]
T
-
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
T
-
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
--------
G
--------
E
--
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
--
C
---
P
--
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
-
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
--
D
V
E
---
T
R
G
-----------
V
E
---
I
--------
L
K
G
L
----
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
N
V
E
V
------------
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
D
-
D
S
L
-
V
R
Q
L
Y
N
A
P
T
-
I
-
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
-
E
D
A
G
L
R
V
A
G
R
S
----
G
----
D
D
Q
L
V
E
I
I
E
V
P
--
N
--
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
22
PsiBlast_CBE
96.80
63%
-93
- C3 -
-
1S1M
2
PYRG_ECOLI
B:
[3-543]
--
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
-
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
--------
G
--------
E
--
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
---
N
--
C
P
--
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
-
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
--
D
V
E
---
T
R
G
-----------
V
E
---
I
--------
L
K
G
L
----
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
N
V
E
V
------------
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
D
-
D
S
L
-
V
R
Q
L
Y
N
A
P
T
-
I
-
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
-
E
D
A
G
L
R
V
A
G
R
S
----
G
----
D
D
Q
L
V
E
I
I
E
V
P
--
N
--
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
-
S
E
F
Q
K
R
Q
66
Fugue
88.35
63%
-8
- C3 -
-
1S1M
-
PYRG_ECOLI
A:
[1-544]
M
T
T
N
Y
I
F
V
T
G
G
V
V
S
S
L
G
K
G
I
A
A
A
S
L
A
A
I
L
E
A
R
G
L
N
V
T
I
M
K
L
D
P
Y
I
N
V
D
P
G
T
M
S
P
I
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
I
R
-
T
K
M
S
R
R
N
N
F
T
T
G
R
I
Y
S
D
V
L
R
K
E
R
R
G
D
Y
L
G
A
T
V
Q
V
I
P
H
I
T
N
A
I
K
E
R
V
L
E
G
--------
G
--------
E
--
G
H
D
V
V
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
I
R
Q
M
A
V
E
I
G
R
E
H
T
L
F
M
H
L
T
L
V
P
Y
M
A
A
S
G
E
V
K
T
K
P
T
Q
H
S
V
K
E
L
L
S
I
G
I
Q
P
D
I
L
I
C
R
S
D
R
A
V
P
A
N
E
R
A
K
I
A
L
F
C
N
V
P
E
K
A
V
I
S
L
K
D
V
D
S
I
Y
K
I
P
G
L
L
K
S
Q
G
L
D
D
Y
I
C
K
R
F
S
L
N
--
C
---
P
--
E
A
N
L
S
E
W
E
Q
V
I
F
E
E
--
A
--
N
P
V
S
E
V
T
I
G
M
V
G
K
Y
I
-
E
-
L
P
D
A
Y
K
S
V
I
E
A
L
K
H
G
G
L
K
N
R
V
S
V
N
I
K
L
I
D
S
Q
--
D
V
E
---
T
R
G
-----------
V
E
---
I
--------
L
K
G
L
----
D
A
I
L
V
P
G
G
F
G
Y
R
G
V
E
G
M
I
T
T
A
R
F
A
R
E
N
N
I
P
Y
L
G
I
C
L
G
M
Q
V
A
L
I
D
Y
A
R
H
V
A
N
M
E
N
A
N
S
T
E
F
V
P
D
C
K
Y
P
V
V
A
L
I
T
E
W
R
D
E
N
G
-------------
N
V
E
T
M
R
L
G
A
Q
Q
C
Q
L
-
V
D
-
D
S
L
-
V
R
Q
L
Y
N
A
P
T
-
I
-
V
E
R
H
R
H
R
Y
E
V
N
N
M
L
L
K
Q
I
-
E
D
A
G
L
R
V
A
G
R
S
----
G
----
D
D
Q
L
V
E
I
I
E
V
P
--
N
--
H
P
W
F
V
A
C
Q
F
H
P
E
F
T
S
T
P
R
D
G
H
P
L
F
A
G
F
V
K
A
A
S
E
F
Q
K
R
Q
A
39
HHSearch
81.01
51%
12
- C3 -
-
4ZDJ
3
PYRG_MYCTU
A:
[9-552]
A
-
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
-
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
--------
A
QPDADG--
N
--
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
--
F
---
R
--
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
-
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
--
G
C
E
---
T
T
S
G
A
---------
A
A
---
A
--------
L
G
D
V
----
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
P
-
D
S
V
-
V
A
Q
A
Y
Q
T
T
Q
-
V
-
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
-
S
G
L
R
F
S
G
T
S
----
P
----
D
G
H
L
V
E
F
V
E
Y
P
--
P
DR
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
--
3
PsiBlast_PDB
81.01
50%
5
- C3 -
-
4ZDJ
3
PYRG_MYCTU
A:
[10-546]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
-
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
QPDAD--
G
--------
N
--
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
-----
N
--
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
-
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
--
G
C
E
T
T
-
S
G
A
-----------
A
A
---
A
--------
L
G
D
V
----
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
P
-
D
S
V
-
V
A
Q
A
Y
Q
T
T
Q
-
V
-
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
-
A
E
S
G
L
R
F
S
G
T
S
----
P
----
D
G
H
L
V
E
F
V
E
Y
P
PD
R
--
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
--------
2
PsiBlast_PDB
80.53
50%
3
- C3 -
-
4ZDI
-
PYRG_MYCTU
A:
[10-546]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
-
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
QPDAD--
G
--------
N
--
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
-----
N
--
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
-
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
--
G
C
E
T
T
-
S
G
A
-----------
A
A
---
A
--------
L
G
D
V
----
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
-----------------------
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
P
-
D
S
V
-
V
A
Q
A
Y
Q
T
T
Q
-
V
-
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
-
A
E
S
G
L
R
F
S
G
T
S
----
P
----
D
G
H
L
V
E
F
V
E
Y
P
PD
R
--
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
--------
40
HHSearch
80.51
51%
10
- C3 -
-
4ZDK
3
PYRG_MYCTU
B:
[8-551]
A
-
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
-
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
--------
A
QPDADG--
N
--
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
N
L
P
--
F
---
R
--
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
-
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
--
G
C
E
---
T
T
S
GA---------
A
A
---
A
--------
L
G
D
V
----
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
P
-
D
S
V
-
V
A
Q
A
Y
Q
T
T
Q
-
V
-
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
A
E
-
S
G
L
R
F
S
G
T
S
----
P
----
D
G
H
L
V
E
F
V
E
Y
P
--
P
DR
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
I
D
Y
K
A
G
--
31
PsiBlast_CBE
80.09
50%
4
- C3 -
-
4ZDK
3
PYRG_MYCTU
B:
[9-545]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
-
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
AQPDAD--
G
--------
N
--
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
-----
N
--
L
P
FR
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
-
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
GC
E
T
T
---
S
G
A
-----------
A
A
---
A
--------
L
G
D
V
----
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
P
-
D
S
V
-
V
A
Q
A
Y
Q
T
T
Q
-
V
-
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
-
A
E
S
G
L
R
F
S
G
T
S
----
P
----
D
G
H
L
V
E
F
V
E
Y
P
PD
R
--
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
--------
4
PsiBlast_PDB
79.52
50%
3
- C3 -
-
4ZDK
3
PYRG_MYCTU
A:
[9-545]
--
T
K
H
L
F
V
S
G
G
V
A
S
S
L
G
K
G
L
T
A
S
S
L
G
Q
L
L
T
A
R
G
L
H
V
T
M
Q
K
L
D
P
Y
L
N
V
D
P
G
T
M
N
P
F
Q
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
V
G
H
Y
E
R
F
L
D
R
-
N
L
P
G
S
A
N
V
T
T
G
Q
V
Y
S
T
V
I
A
K
E
R
R
G
E
Y
L
G
D
T
V
Q
V
I
P
H
I
T
D
E
I
K
R
R
I
L
A
M
A
QPDAD--
G
--------
N
--
R
P
D
V
V
I
T
E
I
G
G
T
V
G
D
I
E
S
Q
P
F
L
E
A
A
R
Q
V
R
H
Y
L
G
R
E
D
V
F
F
L
H
V
S
L
V
P
Y
L
A
P
S
G
E
L
K
T
K
P
T
Q
H
S
V
A
A
L
R
S
I
G
I
T
P
D
A
L
I
L
R
C
D
R
D
V
P
E
A
L
K
N
K
I
A
L
M
C
D
V
D
I
D
G
V
I
S
T
P
D
A
P
S
I
Y
D
I
P
K
V
L
H
R
E
E
L
D
A
F
V
V
R
R
L
-----
N
--
L
P
F
R
D
V
D
W
T
E
W
D
D
L
L
R
R
V
--
H
--
E
P
H
E
T
V
R
I
A
L
V
G
K
Y
V
-
E
-
L
S
D
A
Y
L
S
V
A
E
A
L
R
A
G
G
F
K
H
R
A
K
V
E
I
C
W
V
A
S
D
GC
E
T
T
---
S
G
A
-----------
A
A
---
A
--------
L
G
D
V
----
H
G
V
L
I
P
G
G
F
G
I
R
G
I
E
G
K
I
G
A
I
A
Y
A
R
A
R
G
L
P
V
L
G
L
C
L
G
L
Q
C
I
V
I
E
A
A
R
S
V
-
G
L
T
N
A
N
S
A
E
F
D
P
D
T
P
D
P
V
I
A
T
M
----------------------
G
G
T
M
R
L
G
S
Y
P
A
V
L
-
E
P
-
D
S
V
-
V
A
Q
A
Y
Q
T
T
Q
-
V
-
S
E
R
H
R
H
R
Y
E
V
N
N
A
Y
R
D
K
I
-
A
E
S
G
L
R
F
S
G
T
S
----
P
----
D
G
H
L
V
E
F
V
E
Y
P
PD
R
--
H
P
F
V
V
G
T
Q
A
H
P
E
L
K
S
R
P
T
R
P
H
P
L
F
V
A
F
V
G
A
A
--------
32
PsiBlast_CBE
78.35
42%
8
- C3 -
-
5U03
4
PYRG1_HUMAN
D:
[3-547]
----
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
-
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
ALIPVDED
G
--------
L
--
E
P
Q
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
IE
R
--
Q
P
--
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
-
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
--
D
L
E
PIT
S
Q
E
-----------
E
P
---
V
RYHEAWQK
L
C
S
A
----
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
-----------
H
N
P
G
Q
---
M
G
G
T
M
R
L
G
K
R
R
T
L
F
Q
T
K
-
N
S
V
-
M
R
K
L
Y
G
D
A
D
Y
L
-
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
-
E
E
Q
G
L
K
F
V
G
Q
D
----
V
----
E
G
E
R
M
E
I
V
E
L
E
--
D
--
H
P
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
--------
33
PsiBlast_CBE
78.16
42%
8
- C3 -
-
5U03
4
PYRG1_HUMAN
C:
[3-547]
----
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
-
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
ALIPVDED
G
--------
L
--
E
P
Q
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
IE
R
--
Q
P
--
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
-
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
--
D
L
E
PIT
S
Q
E
-----------
E
P
---
V
RYHEAWQK
L
C
S
A
----
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
-----------
H
N
P
G
Q
---
M
G
G
T
M
R
L
G
K
R
R
T
L
F
Q
T
K
-
N
S
V
-
M
R
K
L
Y
G
D
A
D
Y
L
-
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
-
E
E
Q
G
L
K
F
V
G
Q
D
----
V
----
E
G
E
R
M
E
I
V
E
L
E
--
D
--
H
P
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
--------
41
HHSearch
77.99
45%
8
- C3 -
-
5U03
4
PYRG1_HUMAN
C:
[1-553]
--
M
K
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
I
-
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
--------
A
LIPVDEDG
L
--
E
P
Q
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
--
I
ER
Q
P
--
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
-
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
--
D
L
E
---
P
I
T
SQEEPVRYHEA
W
Q
---
K
--------
L
C
S
A
----
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
H
N
-----------
P
G
Q
---
M
G
G
T
M
R
L
G
K
R
R
T
L
F
Q
T
K
-
N
S
V
-
M
R
K
L
Y
G
D
A
D
Y
L
-
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
-
E
E
Q
G
L
K
F
V
G
Q
D
----
V
----
E
G
E
R
M
E
I
V
E
L
E
--
D
--
H
P
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
V
G
R
L
S
H
--
45
HHSearch
77.94
51%
-
* C3 *
-
3NVA
-
PYRG_SULSO
B:
[2-534]
P
-
N
K
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
V
-
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
A
--------
S
KI------
N
--
N
A
E
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
--
D
---
R
--
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
--
K
GI
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
-
K
-
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
--
D
L
E
---
S
D
T
KNL--------
N
E
---
I
--------
L
G
N
V
----
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
L
D
E
Q
K
N
----------
V
T
Q
---
L
G
G
T
M
R
L
G
A
Q
K
I
I
L
-
K
E
-
G
T
I
-
A
Y
Q
L
Y
G
K
K
V
-
V
-
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
-
E
D
A
G
L
V
V
S
G
I
S
----
E
----
N
-
G
L
V
E
I
I
E
L
P
--
S
--
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
5
PsiBlast_PDB
77.88
42%
8
- C3 -
-
5U03
4
PYRG1_HUMAN
A:
[3-547]
----
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
-
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
A
L
IPVDED
G
--------
L
--
E
P
Q
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
I
E
R
--
Q
P
--
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
-
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
--
D
L
E
P
I
T
S
Q
E
-----------
E
P
---
V
R
Y
H
E
A
W
Q
K
L
C
S
A
----
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
-----------
H
N
P
G
Q
---
M
G
G
T
M
R
L
G
K
R
R
T
L
F
Q
T
K
-
N
S
V
-
M
R
K
L
Y
G
D
A
D
Y
L
-
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
-
E
E
Q
G
L
K
F
V
G
Q
D
----
V
----
E
G
E
R
M
E
I
V
E
L
E
--
D
--
H
P
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
--------
34
PsiBlast_CBE
77.76
42%
8
- C3 -
-
5U03
4
PYRG1_HUMAN
B:
[3-547]
----
Y
I
L
V
T
G
G
V
I
S
G
I
G
K
G
I
I
A
S
S
V
G
T
I
L
K
S
C
G
L
H
V
T
S
I
K
I
D
P
Y
I
N
I
D
A
G
T
F
S
P
Y
E
H
G
E
V
F
V
L
D
D
G
G
E
V
D
L
D
L
G
N
Y
E
R
F
L
D
-
I
R
L
T
K
D
N
N
L
T
T
G
K
I
Y
Q
Y
V
I
N
K
E
R
K
G
D
Y
L
G
K
T
V
Q
V
V
P
H
I
T
D
A
I
Q
E
W
V
M
R
Q
ALIPVDED
G
--------
L
--
E
P
Q
V
C
V
I
E
L
G
G
T
V
G
D
I
E
S
M
P
F
I
E
A
F
R
Q
F
Q
F
K
V
K
R
E
N
F
C
N
I
H
V
S
L
V
P
Q
P
S
S
T
G
E
Q
K
T
K
P
T
Q
N
S
V
R
E
L
R
G
L
G
L
S
P
D
L
V
V
C
R
C
S
N
P
L
D
T
S
V
K
E
K
I
S
M
F
C
H
V
E
P
E
Q
V
I
C
V
H
D
V
S
S
I
Y
R
V
P
L
L
L
E
E
Q
G
V
V
D
Y
F
L
R
R
L
D
L
P
IE
R
--
Q
P
--
R
K
M
L
M
K
W
K
E
M
A
D
R
Y
--
D
--
R
L
L
E
T
C
S
I
A
L
V
G
K
Y
T
-
K
-
F
S
D
S
Y
A
S
V
I
K
A
L
E
H
S
A
L
A
I
N
H
K
L
E
I
K
Y
I
D
S
A
--
D
L
E
PIT
S
Q
E
-----------
E
P
---
V
RYHEAWQK
L
C
S
A
----
H
G
V
L
V
P
G
G
F
G
V
R
G
T
E
G
K
I
Q
A
I
A
W
A
R
N
Q
K
K
P
F
L
G
V
C
L
G
M
Q
L
A
V
V
E
F
S
R
N
V
L
G
W
Q
D
A
N
S
T
E
F
D
P
T
T
S
H
P
V
V
V
D
M
P
E
-----------
H
N
P
G
Q
---
M
G
G
T
M
R
L
G
K
R
R
T
L
F
Q
T
K
-
N
S
V
-
M
R
K
L
Y
G
D
A
D
Y
L
-
E
E
R
H
R
H
R
F
E
V
N
P
V
W
K
K
C
L
-
E
E
Q
G
L
K
F
V
G
Q
D
----
V
----
E
G
E
R
M
E
I
V
E
L
E
--
D
--
H
P
F
F
V
G
V
Q
Y
H
P
E
F
L
S
R
P
I
K
P
S
P
P
Y
F
G
L
L
L
A
S
--------
1
PsiBlast_PDB
77.50
49%
-
- C3 -
-
3NVA
-
PYRG_SULSO
A:
[5-534]
----
Y
I
V
V
T
G
G
V
L
S
S
V
G
K
G
T
L
V
A
S
I
G
M
L
L
K
R
R
G
Y
N
V
T
A
V
K
I
D
P
Y
I
N
V
D
A
G
T
M
N
P
Y
M
H
G
E
V
F
V
T
E
D
G
A
E
T
D
L
D
L
G
H
Y
E
R
F
M
D
-
V
N
M
T
K
Y
N
N
I
T
A
G
K
V
Y
F
E
V
I
K
K
E
R
E
G
K
Y
L
G
Q
T
V
Q
I
I
P
H
V
T
D
Q
I
K
D
M
I
R
Y
A
--------
S
--------
K
I
N
N
A
E
I
T
L
V
E
I
G
G
T
V
G
D
I
E
S
L
P
F
L
E
A
V
R
Q
L
K
L
E
E
G
E
D
N
V
I
F
V
H
I
A
L
V
E
Y
L
S
V
T
G
E
L
K
T
K
P
L
Q
H
S
V
Q
E
L
R
R
I
G
I
Q
P
D
F
I
V
G
R
A
T
L
P
L
D
D
E
T
R
R
K
I
A
L
F
T
N
V
K
V
D
H
I
V
S
S
Y
D
V
E
T
S
Y
E
V
P
I
I
L
E
S
Q
K
L
V
S
K
I
L
S
R
L
K
L
E
--
D
---
R
--
Q
V
D
L
T
D
W
I
S
F
V
N
N
I
K
G
I
--
N
S
K
K
T
I
N
I
A
L
V
G
K
Y
T
-
K
-
L
K
D
S
Y
I
S
I
K
E
A
I
Y
H
A
S
A
Y
I
G
V
R
P
K
L
I
W
I
E
S
T
--
D
L
E
---
S
D
T
-----------
K
N
LNE
I
--------
L
G
N
V
----
N
G
I
I
V
L
P
G
F
G
S
R
G
A
E
G
K
I
K
A
I
K
Y
A
R
E
H
N
I
P
F
L
G
I
C
F
G
F
Q
L
S
I
V
E
F
A
R
D
V
L
G
L
S
E
A
N
S
T
E
I
N
P
N
T
K
D
P
V
I
T
L
----
L
D
E
Q
K
N
V
T
Q
---------
L
G
G
T
M
R
L
G
A
Q
K
I
I
L
-
K
E
-
G
T
I
-
A
Y
Q
L
Y
G
K
K
V
-
V
-
Y
E
R
H
R
H
R
Y
E
V
N
P
K
Y
V
D
I
L
-
E
D
A
G
L
V
V
S
G
I
S
----
E
-----
N
G
L
V
E
I
I
E
L
P
--
S
--
N
K
F
F
V
A
T
Q
A
H
P
E
F
K
S
R
P
T
N
P
S
P
I
Y
L
G
F
I
R
A
V
A
S
------
7
PsiBlast_PDB
52.18
41%
-6
- C3 -
-
5N29
-
?
A:
[8-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
R
I
A
F
V
G
K
Y
L
-
Q
D
A
G
D
T
Y
F
S
V
L
Q
C
F
E
H
C
Q
I
A
L
Q
V
R
L
D
I
L
Y
V
D
S
E
--
E
L
E
---
G
P
N
-----------
A
D
---
E
--------
A
R
K
A
L
L
G
C
D
G
I
F
V
P
G
G
F
G
N
R
G
V
D
G
K
C
A
A
A
Q
V
A
R
M
N
N
I
P
Y
F
G
V
-
L
G
M
Q
V
A
V
I
E
L
S
R
N
V
V
G
W
S
D
A
N
S
E
E
F
N
K
E
S
T
H
Q
V
V
---------------
R
I
M
D
C
D
RNK
M
G
A
N
M
H
L
G
A
C
D
V
Y
I
-
V
E
-
K
S
S
I
M
A
K
I
Y
S
K
S
N
-
I
V
V
E
R
H
R
H
R
Y
E
V
N
T
A
Y
F
E
D
L
-
R
K
A
G
L
C
I
S
A
V
T
DPTF
S
----
S
R
C
R
V
E
A
V
E
N
P
--
S
--
L
R
F
F
L
A
V
Q
F
H
P
E
F
I
S
T
P
M
D
P
A
P
T
Y
L
S
F
M
A
A
A
--------
49
HHSearch
50.62
43%
6
- C3 -
-
5N29
-
?
A:
[8-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
R
I
A
F
V
G
K
Y
L
Q
D
-
A
G
D
T
Y
F
S
V
L
Q
C
F
E
H
C
Q
I
A
L
Q
V
R
L
D
I
L
Y
V
D
S
E
--
E
L
E
---
G
P
N
A
D
E
A
-------
R
K
---
A
--------
L
L
G
C
----
D
G
I
F
V
P
G
G
F
G
N
R
G
V
D
G
K
C
A
A
A
Q
V
A
R
M
N
N
I
P
Y
F
G
V
-
L
G
M
Q
V
A
V
I
E
L
S
R
N
V
V
G
W
S
D
A
N
S
E
E
F
N
K
E
S
T
H
Q
V
V
R
I
M
D
C
D
R
------------
N
K
---
M
G
A
N
M
H
L
G
A
C
D
V
Y
I
-
V
E
K
S
S
I
-
M
A
K
I
Y
S
K
S
N
I
V
-
V
E
R
H
R
H
R
Y
E
V
N
T
A
Y
F
E
D
L
-
R
K
A
G
L
C
I
S
A
V
T
----
D
PTFS
S
R
C
R
V
E
A
V
E
N
P
--
S
--
L
R
F
F
L
A
V
Q
F
H
P
E
F
I
S
T
P
M
D
P
A
P
T
Y
L
S
F
M
A
A
A
A
K
K
D
Y
---