@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQJ7: (2017-11-27 )
MPYYTMPDQESLFVRRIGRGEPVLVLSGLGMQSWQWLPFIYANRKEYEFIIPDWRGFGGSKNCAIPEQDAISSHWQDVAHLIEQLKLDKFILMGYSMGATTAMHGMKHAHLAQQLKAYLHIDQTPKISVDATWQYGLFGPLHAQFKQLLNNIYQLLSIHKNAKYLYELSLPHRQKLVRLWVDFIELQSSNPFSPFVFKTALKQPFLQKYLLPIQRLDYLFWYVENYLFHNEDYREALQQLQCPTTFFIGRNSTLYPETGQTLIAHSVEHAKTIYFERSGHTPLLTEPKKFGHEITTFLSELKHAS
Atome Classification :
(20 SA)
.........10........--20-.....--..--.30...-..-...40........50........60........70.-.....-..80........90........100..-.....110.......120.......130.......140.--...--...150.......160.......170.......180......-.190.......200......-.210.-......220.....-..230.......240.......250....-...260.......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPYYTMPD
Q
E
S
L
F
V
R
RIGR--GE-
P
V
L
V
L
--SG--LGMQS
W
-
Q
W
-
L
P
F
I
Y
ANR
K
E
Y
E
F
IIPDWRGFGGSKNCAIP
E
Q
D
A
I
S
-
S
H
W
Q
D
-
V
A
H
L
I
E
Q
LKLD
K
F
I
L
M
GYSMG
A
T
T
A
M
H
-
G
M
K
H
A
H
L
A
Q
Q
L
K
A
Y
LHIDQTP
K
I
S
V
D
A
T
W
QYGLF
G
P
L
H
A
--
Q
F
K
--
Q
L
L
N
N
I
Y
Q
L
L
S
I
HKN
A
K
Y
L
Y
ELSL
P
H
R
Q
K
L
V
R
L
W
V
D
F
I
E
LQS-SNPF
S
P
F
V
F
K
T
A
L
K
Q
P
F
L
Q
K
-
Y
L
L
P
I
-
Q
R
L
D
Y
L
F
W
Y
V
E
N
Y
L-FH
N
E
D
Y
R
E
A
L
Q
QLQCP
T
T
F
F
IGRNSTLYP-ET
G
Q
T
L
I
A
H
SVEH
A
K
T
I
Y
F
ERSGHTPLLT
E
P
K
K
FG
H
E
I
T
T
F
L
S
E
L
KHAS
82
HHSearch
80.83
19%
-98
- C1 -
-
5EGN
-
?
H:
[2-259]
-
P
H
V
E
-
N
D
G
V
K
I
Y
Y
D
S
Y
G
E
--
G
V
-
P
I
V
F
L
--
H
P
--
F
S
T
N
G
G
-
I
W
-
Y
F
Q
T
F
P
F
A
Q
T
N
H
V
I
V
I
D
H
R
G
H
G
R
S
D
K
P
A
--
T
G
Y
S
I
M
-
E
H
A
D
D
-
V
V
A
V
L
D
A
L
K
V
D
R
A
V
F
V
G
N
S
I
G
G
M
I
A
M
Q
-
L
N
L
D
--
H
P
Q
R
V
I
G
N
L
I
L
S
S
G
T
G
L
G
E
G
M
P
--
P
E
----
A
G
A
--
A
F
Q
--
N
D
Y
I
G
---
A
F
G
G
L
-
L
E
G
A
V
S
A
R
S
K
R
E
R
P
E
I
L
A
V
M
K
A
H
--------------
F
S
--
V
P
S
N
F
P
K
H
-
V
F
D
A
--
A
T
A
D
-----
P
N
--
G
-
V
F
A
W
N
I
K
D
R
L
S
S
I
Q
A
P
T
L
V
V
A
G
E
E
D
L
V
T
T
-
V
A
N
N
Q
L
L
A
D
N
I
P
G
A
E
L
R
V
I
N
D
V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
--------
81
HHSearch
79.99
19%
-95
- C1 -
-
5EGN
-
?
F:
[2-261]
-
P
H
V
E
-
N
D
G
V
K
I
Y
Y
D
S
Y
G
E
--
G
V
-
P
I
V
F
L
--
H
P
--
F
S
T
N
G
G
-
I
W
-
Y
F
Q
T
F
P
F
A
Q
T
N
H
V
I
V
I
D
H
R
G
H
G
R
S
D
K
P
A
--
T
G
Y
S
I
M
-
E
H
A
D
D
-
V
V
A
V
L
D
A
L
K
V
D
R
A
V
F
V
G
N
S
I
G
G
M
I
A
M
Q
-
L
N
L
D
--
H
P
Q
R
V
I
G
N
L
I
L
S
S
G
T
G
L
G
E
G
M
P
--
P
E
----
A
G
A
--
A
F
Q
--
N
D
Y
I
G
---
A
F
G
G
L
-
L
E
G
A
V
S
A
R
S
K
R
E
R
P
E
I
L
A
V
M
K
A
H
--------------
F
S
--
V
P
S
N
F
P
K
H
-
V
F
D
A
--
A
T
A
D
-----
P
N
--
G
-
V
F
A
W
N
I
K
D
R
L
S
S
I
Q
A
P
T
L
V
V
A
G
E
E
D
L
V
T
T
-
V
A
N
N
Q
L
L
A
D
N
I
P
G
A
E
L
R
V
I
N
D
V
G
H
F
Y
Q
L
E
R
P
S
E
F
N
E
L
L
R
G
F
V
A
------
3
PsiBlast_PDB
76.25
21%
-30
- C1 -
-
3HI4
4
ESTE_PSEFL
A:
[3-269]
---
F
V
A
K
D
G
T
Q
I
Y
F
K
D
W
G
S
--
G
K
-
P
V
L
F
S
--
H
G
--
W
P
L
D
A
D
-
M
W
E
Y
Q
M
E
Y
L
S
S
R
G
Y
R
T
I
A
F
D
R
R
G
F
G
R
S
D
Q
P
W
T
G
N
D
--
Y
D
-
T
F
A
D
D
-
I
A
Q
L
I
E
H
L
D
L
K
E
V
T
L
V
G
F
S
M
G
G
G
D
V
A
R
-
Y
I
A
R
H
G
S
A
R
V
A
G
L
V
L
L
G
A
V
T
P
L
F
G
Q
K
P
D
Y
P
Q
G
V
P
L
D
V
F
A
--
R
F
K
--
T
E
L
--------
L
K
D
R
A
Q
F
I
S
D
F
N
A
P
-----------
F
Y
G
I
N
K
-
G
Q
V
V
S
Q
G
V
----------
Q
T
-
Q
T
L
Q
I
-
A
L
L
A
S
L
K
A
T
V
D
C
V
T
A
F
A
E
T
D
F
R
P
D
M
A
K
I
D
V
P
T
L
V
I
H
G
D
G
D
Q
I
V
P
F
E
T
T
G
K
V
A
A
E
L
I
K
G
A
E
L
K
V
Y
K
D
A
P
H
G
F
A
V
T
H
A
Q
Q
L
N
E
D
L
L
A
F
L
-------
80
HHSearch
75.98
19%
-87
- C1 -
-
3OOS
5
?
A:
[9-278]
-----
K
T
P
R
G
K
F
E
Y
F
L
K
G
E
--
G
P
-
P
L
C
V
T
--
H
L
--
Y
S
E
Y
N
D
-
N
G
-
N
T
F
A
N
P
F
T
D
H
Y
S
V
Y
L
V
N
L
K
G
C
G
N
S
D
S
A
K
N
D
S
E
Y
S
M
T
-
E
T
I
K
D
-
L
E
A
I
R
E
A
L
Y
I
N
K
W
G
F
A
G
H
S
A
G
G
M
L
A
L
V
-
Y
A
T
E
--
A
Q
E
S
L
T
K
I
I
V
G
G
A
A
A
S
K
E
Y
A
S
H
K
D
S
I
-
Y
C
S
K
N
V
--
K
F
N
--
R
-
I
V
S
I
M
N
A
L
N
D
D
S
------
T
V
Q
-
E
E
R
K
A
L
S
R
E
W
A
L
M
-------
S
F
Y
S
E
E
K
L
E
E
A
L
K
L
P
N
S
G
K
-
T
V
------
G
N
R
L
N
Y
F
-
R
Q
V
E
-
Y
K
D
Y
D
V
R
Q
K
L
K
F
V
K
I
P
S
F
I
Y
C
G
K
H
D
V
Q
C
P
-
Y
I
F
S
C
E
I
A
N
L
I
P
N
A
T
L
T
K
F
E
E
S
N
H
N
P
F
V
E
E
I
D
K
F
N
Q
F
V
N
D
T
L
-------
90
HHSearch
75.15
19%
-103
- C1 -
-
3KXP
-
AAMHY_RHILO
F:
[56-314]
-------
G
R
I
T
L
N
V
R
E
K
G
S
--
G
P
-
L
M
L
F
F
--
H
G
--
I
T
S
N
S
A
-
V
F
-
E
P
L
M
I
R
L
S
D
R
F
T
T
I
A
V
D
Q
R
G
H
G
L
S
D
K
P
E
--
T
G
Y
E
A
N
-
D
Y
A
D
D
-
I
A
G
L
I
R
T
L
A
R
G
H
A
I
L
V
G
H
S
L
G
A
R
N
S
V
T
-
A
A
A
K
--
Y
P
D
L
V
R
S
V
V
A
I
D
F
T
P
Y
I
E
T
E
A
L
--
D
A
-
L
E
-----------
A
R
V
N
A
G
S
Q
L
F
E
D
I
---
K
A
V
E
A
Y
-------
L
A
G
R
Y
P
N
I
P
A
-
D
A
-
I
R
I
R
A
E
S
G
Y
Q
P
-
V
-
D
G
G
L
R
P
-
L
A
----
S
S
A
A
M
A
Q
T
-
A
R
----
G
L
R
S
D
L
V
P
A
Y
R
D
V
T
K
P
V
L
I
V
R
G
E
S
S
K
L
V
S
-
A
A
A
L
A
K
T
S
R
L
R
P
D
L
P
V
V
V
V
P
G
A
D
H
Y
V
N
E
V
S
P
E
I
T
L
K
A
I
T
N
F
I
D
A
-----
4
PsiBlast_PDB
74.07
22%
-18
- C1 -
-
3HEA
5
ESTE_PSEFL
A:
[3-269]
---
F
V
A
K
D
G
T
Q
I
Y
F
K
D
W
G
S
--
G
K
-
P
V
L
F
S
--
H
G
--
W
P
L
D
A
D
-
M
W
E
Y
Q
M
E
Y
L
S
S
R
G
Y
R
T
I
A
F
D
R
R
G
F
G
R
S
D
Q
P
W
T
G
N
D
--
Y
D
-
T
F
A
D
D
-
I
A
Q
L
I
E
H
L
D
L
K
E
V
T
L
V
G
F
S
M
G
G
G
D
V
A
R
-
Y
I
A
R
H
G
S
A
R
V
A
G
L
V
L
L
G
A
V
T
P
I
F
G
Q
K
P
D
Y
P
Q
G
V
P
L
D
V
F
A
--
R
F
K
T
-
E
L
L
K
D
R
A
Q
F
I
S
------------------------
D
F
------
N
A
P
F
Y
G
-
I
N
K
G
Q
V
V
S
Q
G
V
Q
T
-
Q
T
L
Q
I
-
A
L
L
A
S
L
K
A
T
V
D
C
V
T
A
F
A
E
T
D
F
R
P
D
M
A
K
I
D
V
P
T
L
V
I
H
G
D
G
D
Q
I
V
P
F
E
T
T
G
K
V
A
A
E
L
I
K
G
A
E
L
K
V
Y
K
D
A
P
H
G
F
A
V
T
H
A
Q
Q
L
N
E
D
L
L
A
F
L
-------
14
PsiBlast_PDB
72.65
21%
-59
- C1 -
-
1M33
3
BIOH_ECOLI
A:
[16-252]
-------------------------
L
V
L
L
--
H
G
--
W
G
L
N
A
E
-
V
W
-
R
C
I
D
E
E
L
S
S
H
F
T
L
H
L
V
D
L
P
G
F
G
R
S
R
G
F
G
-----
A
L
S
---
L
A
D
-
M
A
E
A
V
L
Q
Q
A
P
D
K
A
I
W
L
G
W
S
L
G
G
L
V
A
S
Q
I
A
L
T
H
P
---
E
R
V
R
A
L
V
T
V
A
S
S
P
C
F
S
A
R
D
E
W
P
-
G
I
K
P
D
V
L
A
--
G
F
Q
--
Q
Q
L
S
D
D
Q
Q
-----------------------
R
T
V
E
R
F
L
A
L
Q
T
-
M
G
T
E
T
A
R
Q
D
A
R
A
L
K
K
T
V
L
A
----
L
P
M
-
P
E
V
D
V
L
N
G
G
L
E
--
I
-
L
K
T
V
D
L
R
Q
P
L
Q
N
V
S
M
P
F
L
R
L
Y
G
Y
L
D
G
L
V
P
-
R
K
V
V
P
-
L
D
K
L
W
P
H
S
E
S
Y
I
F
A
K
A
A
H
A
P
F
I
S
H
P
A
E
F
C
H
L
L
V
A
L
--------
20
PsiBlast_PDB
71.12
21%
-11
- C1 -
-
1IUP
-
?
A:
[22-272]
----------------
V
G
E
--
G
Q
-
P
V
I
L
I
H
G
S
G
--
P
G
V
S
A
Y
A
N
W
-
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
---
P
E
N
Y
N
Y
S
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
---------
I
A
T
A
L
R
Y
S
E
R
V
D
R
M
V
L
M
G
A
A
G
T
-
R
F
D
V
T
E
G
L
N
A
V
W
G
Y
T
--
P
S
I
E
N
M
R
N
L
L
D
I
-----
F
A
Y
D
R
S
L
V
-
T
D
E
L
A
R
L
-----
R
Y
E
A
-
S
-------
I
Q
P
G
F
Q
E
S
F
S
S
M
-
F
P
E
P
R
-
Q
R
------
W
I
D
A
L
A
-
S
S
D
E
D
----
I
K
T
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
-
L
S
S
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
E
Q
T
D
R
F
N
R
L
V
V
E
F
F
N
E
-----
2
PsiBlast_PDB
70.99
22%
-20
- C1 -
-
4ETW
1
BIOH_SHIFL
A:
[10-252]
-----------------
G
Q
--
G
N
-
V
H
L
V
L
L
-
H
G
--
W
G
L
N
A
E
-
V
W
-
R
C
I
D
E
E
L
S
S
H
F
T
L
H
L
V
D
L
P
G
F
G
R
S
R
G
F
G
-----
A
L
S
-
L
--
A
D
-
M
A
E
A
V
L
Q
Q
A
P
D
K
A
I
W
L
G
W
A
L
G
G
L
V
A
S
Q
I
A
L
T
H
P
---
E
R
V
Q
A
L
V
T
V
A
S
S
P
C
F
S
A
R
D
E
W
P
-
G
I
K
P
D
V
L
A
--
G
F
Q
--
Q
Q
L
S
D
D
F
Q
-----------------------
R
T
V
E
R
F
L
A
L
Q
T
-
M
G
T
E
T
A
R
Q
D
A
R
A
L
K
K
T
V
L
A
----
L
P
M
-
P
E
V
D
V
L
N
G
G
L
E
--
I
-
L
K
T
V
D
L
R
Q
P
L
Q
N
V
S
M
P
F
L
R
L
Y
G
Y
L
D
G
L
V
P
-
R
K
V
V
P
M
L
D
K
L
W
P
H
S
E
S
Y
I
F
A
K
A
A
H
A
P
F
I
S
H
P
A
E
F
C
H
L
L
V
A
L
--------
16
PsiBlast_PDB
70.88
20%
-12
- C1 -
-
2D0D
-
?
A:
[22-272]
----------------
V
G
E
--
G
Q
-
P
V
I
L
I
H
G
S
G
--
P
G
V
S
A
Y
A
N
W
-
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
---
P
E
N
Y
N
Y
S
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
S
F
G
G
G
L
A
---------
I
A
T
A
L
R
Y
S
E
R
V
D
R
M
V
-----------
L
M
G
A
V
G
T
--
R
F
D
VT
E
G
L
N
A
V
W
G
Y
T
P
S
I
E
N
M
R
N
L
L
D
I
-
F
A
Y
D
R
S
L
V
T
D
E
L
A
R
L
R
Y
E
A
-
S
-------
I
Q
P
G
F
Q
E
S
F
S
S
M
-
F
P
E
P
R
-
Q
R
------
W
I
D
A
L
A
-
S
S
D
E
D
----
I
K
T
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
-
L
S
S
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
E
Q
T
D
R
F
N
R
L
V
V
E
F
F
N
E
-----
7
PsiBlast_PDB
70.70
21%
0
- C1 -
-
3IA2
6
ESTE_PSEFL
A:
[3-269]
---
F
V
A
K
D
G
T
Q
I
Y
F
K
D
W
G
S
--
G
K
-
P
V
L
F
S
--
H
G
W
L
L
D
A
D
M
W
-
E
Y
--
Q
M
E
Y
L
S
S
R
G
Y
R
T
I
A
F
D
R
R
G
F
G
R
S
D
Q
P
W
T
G
N
D
--
Y
D
-
T
F
A
D
D
-
I
A
Q
L
I
E
H
L
D
L
K
E
V
T
L
V
G
F
S
M
G
G
G
D
V
A
R
-
Y
I
A
R
H
G
S
A
R
V
A
G
L
V
L
L
G
A
V
T
P
L
F
G
Q
K
P
D
Y
P
Q
G
V
P
L
D
V
F
A
--
R
F
K
--
T
E
L
--------
L
K
D
R
A
Q
F
I
S
D
F
N
A
P
-----------
F
Y
G
I
N
K
-
G
Q
V
V
S
Q
G
V
----------
Q
T
-
Q
T
L
Q
I
-
A
L
L
A
S
L
K
A
T
V
D
C
V
T
A
F
A
E
T
D
F
R
P
D
M
A
K
I
D
V
P
T
L
V
I
H
G
D
G
D
Q
I
V
P
F
E
T
T
G
K
V
A
A
E
L
I
K
G
A
E
L
K
V
Y
K
D
A
P
H
G
F
A
V
T
H
A
Q
Q
L
N
E
D
L
L
A
F
L
-------
8
PsiBlast_PDB
70.14
21%
-1
- C1 -
-
1VA4
4
ESTE_PSEFL
A:
[3-269]
---
F
V
A
K
D
G
T
Q
I
Y
F
K
D
W
G
S
--
G
K
-
P
V
L
F
S
--
H
G
W
L
L
D
A
D
M
W
-
E
Y
--
Q
M
E
Y
L
S
S
R
G
Y
R
T
I
A
F
D
R
R
G
F
G
R
S
D
Q
P
W
T
G
N
D
--
Y
D
-
T
F
A
D
D
-
I
A
Q
L
I
E
H
L
D
L
K
E
V
T
L
V
G
F
S
M
G
G
G
D
V
A
R
-
Y
I
A
R
H
G
S
A
R
V
A
G
L
V
L
L
G
A
V
T
P
L
F
G
Q
K
P
D
Y
P
Q
G
V
P
L
D
V
F
A
--
R
F
K
--
T
E
L
--------
L
K
D
R
A
Q
F
I
S
D
F
N
A
P
-----------
F
Y
G
I
N
K
-
G
Q
V
V
S
Q
G
V
----------
Q
T
-
Q
T
L
Q
I
-
A
L
L
A
S
L
K
A
T
V
D
C
V
T
A
F
A
E
T
D
F
R
P
D
M
A
K
I
D
V
P
T
L
V
I
H
G
D
G
D
Q
I
V
P
F
E
T
T
G
K
V
A
A
E
L
I
K
G
A
E
L
K
V
Y
K
D
A
P
H
G
F
A
V
T
H
A
Q
Q
L
N
E
D
L
L
A
F
L
-------
98
Fugue
69.29
19%
-13
- C1 -
-
1M33
3
BIOH_ECOLI
A:
[3-258]
----------
N
I
W
W
Q
T
K
G
Q
--
G
N
V
H
L
V
L
L
--
H
G
--
W
G
L
N
A
E
-
V
W
-
R
C
I
D
E
E
L
S
S
H
F
T
L
H
L
V
D
L
P
G
F
G
R
S
R
G
F
G
-------
A
-
L
S
L
A
D
M
A
E
A
V
L
Q
Q
A
-
P
D
K
A
I
W
L
G
W
S
L
G
G
L
V
A
S
Q
-
I
A
L
T
H
--
P
E
R
V
R
A
L
V
T
V
A
S
S
P
C
F
S
A
R
D
E
W
P
----------------------------
G
I
K
P
D
V
L
A
G
F
Q
Q
Q
L
S
D
D
Q
Q
R
T
V
E
R
F
L
A
L
Q
T
M
G
T
E
T
-----
A
R
Q
D
A
R
A
L
K
K
T
-
V
L
A
L
P
M
P
E
V
D
V
L
N
G
G
L
E
--
I
-
L
K
T
V
D
L
R
Q
P
L
Q
N
V
S
M
P
F
L
R
L
Y
G
Y
L
D
G
L
V
P
-
R
K
V
V
P
L
-
D
K
L
W
P
H
S
E
S
Y
I
F
A
K
A
A
H
A
P
F
I
S
H
P
A
E
F
C
H
L
L
V
A
L
K
Q
R
V
G
S
--
5
PsiBlast_PDB
69.29
22%
-2
- C1 -
-
3T4U
5
ESTE_PSEFL
A:
[3-269]
---
F
V
A
K
D
G
T
Q
I
Y
F
K
D
W
G
S
--
G
K
-
P
V
L
F
S
--
H
G
W
I
L
D
A
D
M
W
-
E
Y
--
Q
M
E
Y
L
S
S
R
G
Y
R
T
I
A
F
D
R
R
G
F
G
R
S
D
Q
P
W
T
G
N
D
--
Y
D
-
T
F
A
D
D
-
I
A
Q
L
I
E
H
L
D
L
K
E
V
T
L
V
G
F
S
M
G
G
G
D
V
A
R
-
Y
I
A
R
H
G
S
A
R
V
A
G
L
V
L
L
G
A
V
T
P
L
F
G
Q
K
P
D
Y
P
Q
G
V
P
L
D
V
F
A
--
R
F
K
T
-
E
L
L
K
D
R
A
Q
F
I
S
------------------------
D
F
------
N
A
P
F
Y
G
-
I
N
K
G
Q
V
V
S
Q
G
V
Q
T
-
Q
T
L
Q
I
-
A
L
L
A
S
L
K
A
T
V
D
C
V
T
A
F
A
E
T
D
F
R
P
D
M
A
K
I
D
V
P
T
L
V
I
H
G
D
G
D
Q
I
V
P
F
E
T
T
G
K
V
A
A
E
L
I
K
G
A
E
L
K
V
Y
K
D
A
P
H
G
F
A
V
T
H
A
Q
Q
L
N
E
D
L
L
A
F
L
-------
19
PsiBlast_PDB
69.19
21%
-9
- C1 -
-
1IUO
-
?
A:
[22-272]
----------------
V
G
E
--
G
Q
-
P
V
I
L
I
H
G
S
G
--
P
G
V
S
A
Y
A
N
W
-
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
---
P
E
N
Y
N
Y
S
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
---------
I
A
T
A
L
R
Y
S
E
R
V
D
R
M
V
L
M
G
A
A
G
T
-
R
F
D
V
T
E
G
L
N
A
V
W
G
Y
T
--
P
S
I
E
N
M
R
N
L
L
D
I
-----
F
A
Y
D
R
S
L
V
-
T
D
E
L
A
R
L
-----
R
Y
E
A
-
S
-------
I
Q
P
G
F
Q
E
S
F
S
S
M
-
F
P
E
P
R
-
Q
R
------
W
I
D
A
L
A
-
S
S
D
E
D
----
I
K
T
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
-
L
S
S
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
E
Q
T
D
R
F
N
R
L
V
V
E
F
F
N
E
-----
6
PsiBlast_PDB
68.79
22%
-2
- C1 -
-
3T52
6
ESTE_PSEFL
A:
[3-269]
---
F
V
A
K
D
G
T
Q
I
Y
F
K
D
W
G
S
--
G
K
-
P
V
L
F
S
--
H
G
W
I
L
D
A
D
M
W
-
E
Y
--
Q
M
E
Y
L
S
S
R
G
Y
R
T
I
A
F
D
R
R
G
F
G
R
S
D
Q
P
W
T
G
N
D
--
Y
D
-
T
F
A
D
D
-
I
A
Q
L
I
E
H
L
D
L
K
E
V
T
L
V
G
F
S
M
G
G
G
D
V
A
R
-
Y
I
A
R
H
G
S
A
R
V
A
G
L
V
L
L
G
A
V
T
P
L
F
G
Q
K
P
D
Y
P
Q
G
V
P
L
D
V
F
A
--
R
F
K
T
-
E
L
L
K
D
R
A
Q
F
I
S
------------------------
D
F
------
N
A
P
F
Y
G
-
I
N
K
G
Q
V
V
S
Q
G
V
Q
T
-
Q
T
L
Q
I
-
A
L
L
A
S
L
K
A
T
V
D
C
V
T
A
F
A
E
T
D
F
R
P
D
M
A
K
I
D
V
P
T
L
V
I
H
G
D
G
D
Q
I
V
P
F
E
T
T
G
K
V
A
A
E
L
I
K
G
A
E
L
K
V
Y
K
D
A
P
H
G
F
A
V
T
H
A
Q
Q
L
N
E
D
L
L
A
F
L
-------
84
HHSearch
68.41
19%
-23
- C1 -
-
1CQW
-
DHAA_RHOSD
A:
[11-292]
---
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
RD
G
T
-
P
V
L
F
L
--
H
G
--
N
P
T
S
S
Y
-
L
W
-
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
D
--
L
D
Y
F
F
D
-
D
H
V
R
Y
-
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
-
W
A
K
R
--
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
P
I
P
T
W
D
E
W
P
-
E
F
A
---------
R
--
E
T
F
Q
A
F
----
R
T
A
D
V
G
R
E
L
--
I
I
D
-
Q
N
A
F
I
E
G
V
L
P
K
C
V
-
V
R
P
-
L
T
E
V
E
M
D
H
Y
R
E
P
F
L
K
P
V
D
R
E
-
P
L
W
R
F
P
N
E
I
P
I
A
G
E
-
P
A
N
I
V
-
A
L
V
E
A
Y
M
N
W
L
H
Q
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
-
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
G
L
A
S
--
77
HHSearch
68.19
20%
-18
* C1 *
-
3G9X
1
DHAA_RHOSO
A:
[15-296]
----
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
RD
G
T
-
P
V
L
F
L
--
H
G
--
N
P
T
S
S
Y
-
L
W
-
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
P
D
--
L
D
Y
F
F
D
-
D
H
V
R
Y
-
L
D
A
F
I
E
A
L
G
L
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
-
W
A
K
R
--
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
P
F
P
T
W
D
E
W
P
E
--
F
A
--------
R
--
E
T
F
Q
A
F
R
T
A
D
V
G
R
-
E
--
L
I
I
D
Q
N
A
F
I
E
G
A
L
P
K
C
V
V
R
P
--
L
T
---
E
V
-
E
M
D
H
Y
R
E
P
F
L
K
P
V
D
R
E
P
L
W
R
F
P
-
N
E
L
P
I
A
G
-
E
P
A
N
I
V
-
A
L
V
E
A
Y
M
N
W
L
H
Q
S
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
-
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
H
H
H
-
18
PsiBlast_PDB
67.58
21%
-8
- C1 -
-
1IUN
-
?
A:
[22-272]
----------------
V
G
E
--
G
Q
-
P
V
I
L
I
H
G
S
G
--
P
G
V
S
A
Y
A
N
W
-
R
L
T
I
P
A
L
S
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
---
P
E
N
Y
N
Y
S
K
D
S
W
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
---------
I
A
T
A
L
R
Y
S
E
R
V
D
R
M
V
L
M
G
A
A
G
T
-
R
F
D
V
T
E
G
L
N
A
V
W
G
Y
T
--
P
S
I
E
N
M
R
N
L
L
D
I
-----
F
A
Y
D
R
S
L
V
-
T
D
E
L
A
R
L
-----
R
Y
E
A
-
S
-------
I
Q
P
G
F
Q
E
S
F
S
S
M
-
F
P
E
P
R
-
Q
R
------
W
I
D
A
L
A
-
S
S
D
E
D
----
I
K
T
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
-
L
S
S
S
L
R
L
G
E
L
I
D
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
E
Q
T
D
R
F
N
R
L
V
V
E
F
F
N
E
-----
17
PsiBlast_PDB
66.27
21%
-76
- C1 -
-
3OOS
5
?
A:
[50-278]
-------------------------------------------------------
Y
S
V
Y
L
V
N
L
K
G
C
G
N
S
D
S
A
K
N
D
S
E
Y
S
M
T
-
E
T
I
K
D
-
L
E
A
I
R
E
A
L
Y
I
N
K
W
G
F
A
G
H
S
A
G
G
M
L
A
L
----
V
Y
A
T
E
A
Q
E
S
L
T
K
I
I
V
G
G
A
A
A
S
K
E
Y
A
S
H
K
D
S
I
Y
C
S
K
N
V
--
K
F
N
--
R
I
V
S
-
I
M
N
A
L
N
D
D
S
T
V
Q
-------
E
E
R
K
A
L
S
R
E
W
A
----
L
M
S
-
F
--
Y
S
E
E
K
L
E
E
A
L
K
L
P
N
S
G
K
-
T
V
G
---
N
R
L
N
Y
-
F
R
Q
V
E
----
Y
K
D
Y
D
V
R
Q
K
L
K
F
V
K
I
P
S
F
I
Y
C
G
K
H
D
V
Q
C
P
-
Y
I
F
S
C
E
I
A
N
L
I
P
N
A
T
L
T
K
F
E
E
S
N
H
N
P
F
V
E
E
I
D
K
F
N
Q
F
V
N
D
T
L
-------