@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQK0: (2017-11-27 )
MLSRQLEVSLRLAVSMARQKRHEFLTVEHLLLALLDNDSAVNALKACGADIVSLRKELEEYVEQHTPKLGENSEQAPHPTESFDRILQRAIFHVQSSGGDRTVEGADVLVAMYSERDSFAVYLLKRHQINRLTLTQYLSHGTRKDEVQVEEEVEDIEGESNSGNAGPLELYTLNLNVEAQKGKTDPLIGREKEIERTAQILCRRRKNNPLLVGDPGVGKTSIAEGLAWLIVNGKAPKPLSHAEIYSLDIGALVAGTKYRGDFEKRLKQLLNALKKNPNAILFIDEIHMIIGAGSSMGSTMDASNLIKPALANGTLRCIGSTTFQEYRQVFEKDHALSRRFQKIDVNEPSISETIDILRGLKTKFEDFHHVQYDDKALVSAVELSAKFINDRFLPDKAIDVIDEAGAQCRLKAESEDSLITVENIEDIVSKIARIPPKTVSKDDKSVLENLERDLKRVVFGQDEAITALASAIKLSRAGLKSPDKPVGSFVFAGPTGVGKTEVTKQLAKLLGVELVRFDMSEYMERHAVSRLIGAPPGYVGYDQGGLLTDAIHKNPHCVLLLDEIEKAHPDVFNLLLQIMDHGALTDNNGRKSDFRNVIIVLTTNIGAESISRASIGFTEQDHSSDNQEAMKRAFSPEFRNRLDGVIQFKALPTTVIESVVDKFLTELQAQLDEKRVVLDVDQSACDWLATNGYDRLMGARPMQRLIQEHLKKPLAEMILFGELADHGGNVAVSVKKEDGKAVGLKLEVFEDHHTAEPA
Atome Classification :
(25 SA)
-.........10........20........30........--40-.........50........60........-70........80........90........100.......110.......120.......130--.........140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270...-...-.280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......-------------------410--------...-----------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------------------------...420--------------------------.....-----------------------...430.......440.......450.......460.......470.......480.......490.......500.....-.-.510-.---..--......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.-.-.....620.-------........-------630.......640.......650.......660.......670.--......680.......690.......700.......710.......720.......730.......740.......750......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MLS
R
Q
L
E
V
S
L
R
L
A
V
S
M
A
R
Q
K
R
H
E
F
L
T
V
E
H
L
L
L
A
L
LDND
S
--
A
--
V
N
A
L
K
A
C
G
A
D
I
V
S
L
R
K
E
L
E
E
Y
V
E
QHTPKL-GENSEQAPHP
T
E
S
F
D
R
I
L
Q
R
A
I
F
H
V
QSSGGDRTVEGA
D
V
L
V
A
M
YSERD
S
F
A
V
Y
L
L
K
RHQI
N
----
R
L
T
L
T
Q
Y
L
S
HGTRKD
E
V
Q
V
E
E
E
V
E
DIEGESNSGNAG
P
L
E
L
Y
T
L
N
L
N
V
E
AQKGKTDPLIG
R
E
K
E
I
E
R
T
A
Q
I
L
C
R
RRKNN
P
L
L
V
GDPGV
G
K
T
S
I
AE
G
L
A
W
L
I
VNGKAPKPLSHA
E
I
Y
S
L
D
I
G
A
L
VAGTKYRG
D
F
E
K
R
L
K
Q
L
L
N
A
L
KK-NP
N
-
A
I
L
F
I
DE
I
H
M
I
I
GAGSSMGSTM
D
A
S
N
L
I
K
P
A
LANG
T
L
R
CIGS
T
T
F
Q
E
Y
R
Q
V
F
E
K
D
H
A
L
S
R
R
F
QKIDVNEP
S
I
S
E
T
I
D
I
L
R
G
L
K
T
K
F
E
DFHHVQYD
D
K
A
L
V
S
A
V
E
L
S
A
K
F
I
NDRFLP
D
K
A
I
D
V
I
D
EAG
A
Q
C
R
-------------------
L
K
A--------ESE-----------------------------------------------------------------------------------------------------------------------------------D---------------------------------------------------------------------------------------------------
S
L
I
T
V
---------------------------
E
N
I
E
D
-----------------------
I
V
S
K
I
ARIPPKTVSK
D
D
K
S
V
L
E
N
L
E
R
D
L
K
R
V
VFGQ
D
E
A
I
T
A
L
A
S
A
I
K
L
S
RAGLKSPDKPV
G
S
F
V
F
AGPTGV
G
K
T
E
V
T
K
Q
L
A
-
K
-
L
L
---
G
---
V
E
--
L
V
R
F
D
M
S
E
Y
M
E
R
H
A
V
S
R
L
IGAPPGYVGYDQGGL
L
T
D
A
IHKNP
H
C
V
L
L
L
D
E
I
E
K
AH
P
D
V
F
N
L
L
L
Q
I
MDHGALTDNNGRKSDFR
N
V
I
I
V
L
TTNIG
A
E
SISRA-S-IGFTEQ--D-------HSS
D
N
Q
E
A
-------
M
K
R
AF
S
P
E
F
R
N
RLD
G
V
I
Q
FKAL
P
T
T
V
I
E
S
V
V
D
K
F
L
T
E
L
Q
A
Q
LDE--K
R
V
V
L
DVDQSAC
D
W
L
ATN
G
Y
D
R
LMG
A
R
P
M
Q
R
L
I
Q
E
H
L
K
K
P
L
A
E
M
I
L
F
G
E
L
ADHGG
N
V
A
V
S
V
KKEDG
K
A
V
G
L
K
L
E
V
F
EDHHTAEPA
96
Fugue
85.89
43%
0
- C- -
-
1QVR
-
CLPB_THET8
A:
[4-850]
E
R
W
T
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
K
H
Q
A
I
D
L
P
H
L
W
A
V
L
L
K
D
E
R
S
L
A
--
W
R
L
L
E
K
A
G
A
D
P
K
A
L
K
E
L
Q
E
R
E
L
A
R
L
P
K
V
---
E
G
A
E
V
G
Q
Y
L
T
S
R
L
S
G
A
L
N
R
A
E
G
L
M
E
E
L
K
-
D
R
Y
V
A
V
D
T
L
V
L
A
L
A
E
A
T
P
G
L
P
-------
G
L
E
----
A
L
K
G
A
L
K
E
L
R
G
G
R
T
V
Q
-----------
T
E
H
A
E
S
T
Y
N
A
L
E
Q
Y
G
I
D
L
T
R
L
A
A
E
G
K
L
D
P
V
I
G
R
D
E
E
I
R
R
V
I
Q
I
L
L
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
V
E
G
L
A
Q
R
I
V
K
G
D
V
P
E
G
L
K
G
K
R
I
V
S
L
Q
-----------
M
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
-
S
Q
G
E
V
I
L
F
I
D
E
L
--------------------
K
P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
-
E
K
D
P
A
L
E
R
R
F
Q
P
V
Y
V
D
E
P
T
V
E
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
R
I
S
D
S
A
I
I
A
A
A
T
L
S
H
R
Y
I
T
E
R
R
L
P
D
K
A
I
D
L
I
D
E
A
A
A
R
L
R
M
A
LE
S
A
P
E
E
I
D
A
L
E
R
K
K
L
Q
L
E
I
--------
E
R
E
-----------------------------------------------------------------------------------------------------------------------------------
A
L
K
K
EKD
P
D
S
Q
E
RL
K
A
I
E
A
E
I
A
K
L
T
E
E
I
A
K
L
R
A
E
W
E
R
E
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
I
E
L
A
E
R
Q
YDLN
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
S
E
K
L
RGARFVR
L
E
V
T
E
---------------------------
E
D
I
A
E
-----------------------
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
-
A
-
T
L
F
DT
E
---
E
A
--
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
--------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
-
L
Q
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
G
P
A
-----
G
L
V
F
A
V
P
A
--------
1
PsiBlast_PDB
79.06
62%
25
- C4 -
-
1KSF
9
CLPA_ECOLI
X:
[1-738]
-
M
L
N
Q
E
L
E
L
S
L
N
M
A
F
A
R
A
R
E
H
R
H
E
F
M
T
V
E
H
L
L
L
A
L
L
S
N
P
S
--
A
--
R
E
A
L
E
A
C
S
V
D
L
V
A
L
R
Q
E
L
E
A
F
I
E
Q
T
T
P
V
L
P
A
S
E
E
E
R
D
T
Q
P
T
L
S
F
Q
R
V
L
Q
R
A
V
F
H
V
Q
S
S
G
R
N
E
-
V
T
G
A
N
V
L
V
A
I
F
S
E
Q
E
S
Q
A
A
Y
L
L
R
K
H
E
V
S
----
R
L
D
V
V
N
F
I
S
H
G
T
R
------------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
Q
-
D
T
N
-
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
-------------------
L
M
P
--------
V
S
K
R----------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------
K
T
V
N
V
---------------------------
A
D
I
E
S
-----------------------
V
V
A
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
-
K
-
A
L
---
G
---
I
E
--
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
------------------------
N
S
T
D
A
M
E
E
-------
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
--
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
-
G
G
Q
V
T
V
A
L
D
K
E
---------------------
2
PsiBlast_PDB
78.20
62%
28
- C4 -
-
1R6B
2
CLPA_ECOLI
X:
[1-738]
-
M
L
N
Q
E
L
E
L
S
L
N
M
A
F
A
R
A
R
E
H
R
H
E
F
M
T
V
E
H
L
L
L
A
L
L
S
N
P
S
--
A
--
R
E
A
L
E
A
C
S
V
D
L
V
A
L
R
Q
E
L
E
A
F
I
E
Q
T
T
P
V
L
P
A
S
E
E
E
R
D
T
Q
P
T
L
S
F
Q
R
V
L
Q
R
A
V
F
H
V
Q
S
S
G
R
N
E
-
V
T
G
A
N
V
L
V
A
I
F
S
E
Q
E
S
Q
A
A
Y
L
L
R
K
H
E
V
S
----
R
L
D
V
V
N
F
I
S
H
G
--------------------------
L
E
N
F
T
T
N
L
N
Q
L
A
R
V
G
G
I
D
P
L
I
G
R
E
K
E
L
E
R
A
I
Q
V
L
C
R
R
R
K
N
N
P
L
L
V
G
E
S
G
V
G
K
T
A
I
A
E
G
L
A
W
R
I
V
Q
G
D
V
P
E
V
M
A
D
C
T
I
Y
S
L
D
I
G
---
A
G
T
K
Y
R
G
D
F
E
K
R
F
K
A
L
L
K
Q
L
E
Q
-
D
T
N
-
S
I
L
F
I
D
E
I
H
T
I
I
G
A
G
A
A
S
G
G
Q
V
D
A
A
N
L
I
K
P
L
L
S
S
G
K
I
R
V
I
G
S
T
T
Y
Q
E
F
S
N
I
F
E
K
D
R
A
L
A
R
R
F
Q
K
I
D
I
T
E
P
S
I
E
E
T
V
Q
I
I
N
G
L
K
P
K
Y
E
A
H
H
D
V
R
Y
T
A
K
A
V
R
A
A
V
E
L
A
V
K
Y
I
N
D
R
H
L
P
D
K
A
I
D
V
I
D
E
A
G
A
R
A
R
-------------------
L
M
P
--------
V
S
K
R----------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------------------------------------------------------------------------
K
T
V
N
V
---------------------------
A
D
I
E
S
-----------------------
V
V
A
R
I
A
R
I
P
E
K
S
V
S
Q
S
D
R
D
T
L
K
N
L
G
D
R
L
K
M
L
V
F
G
Q
D
K
A
I
E
A
L
T
E
A
I
K
M
A
R
A
G
L
G
H
E
H
K
P
V
G
S
F
L
F
A
G
P
T
G
V
G
K
T
E
V
T
V
Q
L
S
-
K
-
A
L
---
G
---
I
E
--
L
L
R
F
D
M
S
E
Y
M
E
R
H
T
V
S
R
L
I
G
A
P
P
G
Y
V
G
F
D
Q
G
G
L
L
T
D
A
V
I
K
H
P
H
A
V
L
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
M
D
N
G
T
L
T
D
N
N
G
R
K
A
D
F
R
N
V
V
L
V
M
T
T
N
A
G
V
R
----------------------------
A
M
E
E
-------
I
K
K
I
F
T
P
E
F
R
N
R
L
D
N
I
I
W
F
D
H
L
S
T
D
V
I
H
Q
V
V
D
K
F
I
V
E
L
Q
V
Q
L
D
Q
--
K
G
V
S
L
E
V
S
Q
E
A
R
N
W
L
A
E
K
G
Y
D
R
A
M
G
A
R
P
M
A
R
V
I
Q
D
N
L
K
K
P
L
A
N
E
L
L
F
G
S
L
V
D
-
G
G
Q
V
T
V
A
L
D
K
E
---------------------
67
HHSearch
67.64
41%
47
- C2 -
-
3J3U
-
CLPC_BACSU
B:
[5-804]
-
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
--
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
------
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
-
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
----
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
E
T
G
-----
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
-
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
--------
F
T
T
PPNL
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
QEF
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
WK
E
K
Q
G
Q
E-------------------------------------------------------------------------
N
---------------------------------------------------------------------------------------------------
S
E
V
T
V
---------------------------
D
D
I
A
M
-----------------------
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
-
S
I
FGD
E
---
E
S
--
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
-
V
G
F
N
V
Q
--
D
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
-------
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
-
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
----------------
68
HHSearch
67.10
40%
-
- C2 -
-
3PXI
-
CLPC_BACSU
A:
[5-804]
-
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
--
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
------
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
-
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
----
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
E
T
G
-----
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
A
---------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
--------
F
T
-------------------------------------------------------------------------------------------------------------------------------------PNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQ--------------------------------------------
E
V
T
V
---------------------------
D
D
I
A
M
-----------------------
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
-
S
I
FGD
E
---
E
S
--
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
--------------
S
---
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
------------------------
D
K
V
M
G
E
-------
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
-
K
G
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
----------------
6
PsiBlast_PDB
65.35
38%
58
- C2 -
-
3J3U
-
CLPC_BACSU
A:
[14-802]
----------
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
--
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
-
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
LNKA
R
Q
Q
V
L
Q
L
L
G
S
N
---------
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
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I
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V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
FTTPPNLK
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------
K
L
D
E
V
RKEKDAAVQSQEFEKAASLRDTEQRLR
E
Q
V
E
D
TKKSWKEKQGQENSEVTVDDIAM
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
S
I
F
---
G
---
D
E
ES
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
-
K
Y
V
G
F
N
V
Q
--
D
-------
E
T
Q
N
H
K
D
M
KDKVMGE
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
-
H
K
G
Q
H
I
V
L
D
V
--
E
D
G
E
F
V
----------------
7
PsiBlast_PDB
65.05
36%
-
- C2 -
-
3PXI
-
CLPC_BACSU
A:
[14-802]
----------
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
--
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
-
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
LNKA
R
Q
Q
V
L
Q
L
L
G
S
N
---------
E
T
G
S
-----
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
-------------
A
--------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
FTPNLK--
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------
K
L
D
E
V
RKEKDAAVQSQEFEKAASLRDTEQRLR
E
Q
V
E
D
TKKSWKEKQGQEVTVDDIAM---
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
S
I
F
---
G
---
D
E
ES
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
------------
S
E
K
--
D
-------
K
V
M
G
E
----------
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
-
H
K
G
Q
H
I
V
L
D
V
--
E
D
G
E
F
V
----------------
3
PsiBlast_PDB
63.74
38%
59
- C2 -
-
3J3S
-
CLPC_BACSU
A:
[14-802]
----------
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
--
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
-
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
LNKA
R
Q
Q
V
L
Q
L
L
G
S
N
---------
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
E
L
H
T
L
I
G
A
G
G
A
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
FTTPPNLK
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------
K
L
D
E
V
RKEKDAAVQSQEFEKAASLRDTEQRLR
E
Q
V
E
D
TKKSWKEKQGQENSEVTVDDIAM
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
S
I
F
---
G
---
D
E
ES
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
-
K
Y
V
G
F
N
V
Q
--
D
-------
E
T
Q
N
H
K
D
M
KDKVMGE
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
-
H
K
G
Q
H
I
V
L
D
V
--
E
D
G
E
F
V
----------------
5
PsiBlast_PDB
63.64
38%
51
- C2 -
-
3J3R
-
CLPC_BACSU
A:
[14-802]
----------
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
--
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
-
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
LNKA
R
Q
Q
V
L
Q
L
L
G
S
N
---------
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
FTTPPNLK
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------
K
L
D
E
V
RKEKDAAVQSQEFEKAASLRDTEQRLR
E
Q
V
E
D
TKKSWKEKQGQENSEVTVDDIAM
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
S
I
F
---
G
---
D
E
ES
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
-
K
Y
V
G
F
N
V
Q
--
D
-------
E
T
Q
N
H
K
D
M
KDKVMGE
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
-
H
K
G
Q
H
I
V
L
D
V
--
E
D
G
E
F
V
----------------
4
PsiBlast_PDB
63.22
38%
50
- C2 -
-
3J3T
-
CLPC_BACSU
A:
[14-802]
----------
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
E
GI
A
--
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
------
G
Q
E
M
S
Q
T
I
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
-
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
A
R
V
L
N
N
L
G
V
S
LNKA
R
Q
Q
V
L
Q
L
L
G
S
N
---------
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
-
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
-------------------
L
R
S
FTTPPNLK
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------
K
L
D
E
V
RKEKDAAVQSQEFEKAASLRDTEQRLR
E
Q
V
E
D
TKKSWKEKQGQENSEVTVDDIAM
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
-
E
S
I
F
---
G
---
D
E
ES
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
-
K
Y
V
G
F
N
V
Q
--
D
-------
E
T
Q
N
H
K
D
M
KDKVMGE
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
E
--
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
-
H
K
G
Q
H
I
V
L
D
V
--
E
D
G
E
F
V
----------------
66
HHSearch
60.16
40%
-30
- C3 -
-
5D4W
2
?
A:
[173-888]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
N
E
N
L
S
K
F
C
I
D
M
T
A
M
A
R
E
G
K
I
D
P
V
I
G
R
E
E
E
I
R
R
V
I
R
I
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
T
I
V
E
G
L
A
Q
R
I
V
N
A
D
V
P
D
N
L
A
A
C
K
L
L
S
L
D
V
G
A
L
V
A
G
S
K
Y
R
G
E
F
E
E
R
M
K
G
V
L
K
E
I
Q
E
S
K
E
T
-
I
I
L
F
V
D
A
I
H
L
L
M
G
A
-------
M
D
A
A
N
L
L
K
P
M
L
A
R
G
Q
L
H
C
I
G
A
T
T
L
A
E
Y
R
K
Y
I
E
K
D
A
A
F
E
R
R
F
Q
Q
V
L
V
K
E
P
S
I
S
E
T
I
S
I
L
R
G
L
K
E
K
Y
E
V
H
H
G
V
N
I
A
D
A
A
I
V
A
A
A
N
L
A
A
R
Y
L
T
S
R
R
L
P
D
S
A
V
D
L
I
D
E
A
A
A
A
V
R
-------------------
V
A
R
--------
E
S
Q
P
E
I
I
D
S
L
E
R
R
L
R
Q
L
KIEIHALSREKDEA
S
K
A
R
L
A
Q
A
K
Q
D
A
Q
N
V
E
E
E
L
R
P
L
R
E
K
Y
E
R
E
R
Q
R
G
K
A
I
Q
E
A
K
M
K
L
E
A
L
R
V
K
A
E
D
A
SRMGDHSRA
A
D
L
Q
Y
YAIPEQEAI
I
K
R
L
E
A
E
K
A
A
A
D
A
A
L
N
A
NGADV
G
G
S
M
I
T
---------------------------------------------------------------------------------------------------
D
V
V
G
P
---------------------------
D
Q
I
N
E
-----------------------
I
V
A
R
W
T
G
I
P
V
T
R
L
K
T
S
E
K
----
H
M
E
Q
A
L
S
K
I
V
V
G
Q
K
E
A
V
Q
S
V
S
N
A
I
R
L
Q
R
S
G
L
S
N
P
N
Q
P
-
P
S
F
L
F
C
G
P
S
G
T
G
K
T
L
L
T
K
A
L
A
-
E
-
F
L
FDD
P
---
K
S
--
M
I
R
F
D
M
S
E
Y
Q
E
R
H
S
L
S
R
M
I
G
A
P
P
G
Y
V
G
H
D
A
G
G
Q
L
T
E
A
L
R
R
R
P
F
S
I
L
L
F
D
A
V
E
K
A
A
K
E
V
L
T
V
L
L
Q
L
M
D
D
---
T
D
G
Q
G
R
V
V
D
A
K
N
C
I
V
V
M
T
S
N
------------------DP
T
-------
T
R
E
L
V
M
N
T
-------
L
R
N
Y
F
L
P
E
F
L
N
R
I
S
S
V
V
I
F
N
R
L
T
R
R
E
I
R
K
I
V
D
L
R
I
A
E
I
Q
K
R
L
T
D
N
D
R
N
V
I
I
K
V
S
E
E
A
K
D
K
L
G
A
Q
G
Y
S
P
V
Y
G
A
R
P
L
Q
R
L
L
E
K
E
V
L
N
R
L
A
I
L
I
L
R
G
Q
I
R
-
E
G
E
V
A
H
V
E
L
V
D
G
K
V
Q
------------------
73
HHSearch
55.04
51%
-40
- C2 -
-
4FCV
1
CLPB_THET8
A:
[7-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
-
A
-
T
L
---
F
DTE
E
A
--
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
-
E
G
D
R
V
Q
V
D
V
G
-----------------------
10
PsiBlast_PDB
54.61
49%
-31
- C2 -
-
4LJ5
1
A:
[6-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
---------------------------
E
D
I
A
E
-----------------------
I
V
S
R
W
T
G
I
P
V
S
K
L
L
----
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
23
PsiBlast_CBE
53.97
49%
-43
- C2 -
-
4LJ7
1
C:
[34-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
9
PsiBlast_PDB
53.80
49%
-35
- C2 -
-
4LJ4
-
A:
[6-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
---------------------------
E
D
I
A
E
-----------------------
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
-
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
------------
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
24
PsiBlast_CBE
53.74
49%
-34
- C2 -
-
4LJ7
1
CLPB_THET8
B:
[34-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
11
PsiBlast_PDB
53.72
49%
-35
- C2 -
-
4LJ7
1
CLPB_THET8
A:
[30-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
Q
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
13
PsiBlast_PDB
52.91
49%
-30
- C2 -
-
4LJA
2
A:
[6-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
---------------------------
E
D
I
A
E
-----------------------
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
71
HHSearch
52.63
49%
-25
- C2 -
-
4LJ9
1
A:
[4-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
V
T
E
---------------------------
E
D
I
A
E
-----------------------
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
-
A
-
T
L
---
F
DTE
E
A
--
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
-
E
G
D
R
V
Q
V
D
V
G
P
A
G
L
-------------------
19
PsiBlast_PDB
52.56
50%
-32
- C2 -
-
4FCW
1
CLPB_THET8
A:
[17-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
-
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
12
PsiBlast_PDB
52.55
49%
-28
- C2 -
-
4LJ9
1
A:
[6-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
---------------------------
E
D
I
A
E
-----------------------
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
R
E
K
L
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
18
PsiBlast_PDB
52.13
50%
-33
- C2 -
-
4FCV
1
CLPB_THET8
A:
[17-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
-
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
M
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
M
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
M
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
26
PsiBlast_CBE
51.69
52%
-33
- C2 -
-
4FD2
1
CLPB_THET8
B:
[14-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
-
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
16
PsiBlast_PDB
51.04
52%
-33
- C2 -
-
4FD2
1
CLPB_THET8
A:
[14-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
-
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
G
Y
V
G
Y
E
E
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
-
K
G
W
P
Y
E
--
R
-------
I
R
D
E
V
F
K
V
-------
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
E
--
K
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
E
V
K
E
-
G
D
R
V
Q
V
D
V
------------------------
25
PsiBlast_CBE
50.54
52%
-32
- C2 -
-
4FD2
1
D:
[14-295]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
V
-
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
-
L
F
---
D
---
T
E
EA
M
I
R
I
D
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------------------------