@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQK7: (2017-11-27 )
MLSRVVRQILQATVYDVAIETPLEAAPRISQKLNNTIRFKREDLQPVFSFKLRGAYNRISQLPKEQLERGVICASAGNHAQGVALSGQRLGIPAIIVMPSTTPDIKVQAVKRLGGQVVLHGDSFDIANKYAQQRAEAEGLVFIPPYDDELVIAGQGTIANEILRQWRDVEYVFVAVGGGGLIAGVAAYLGDVAPHVKVIGVEYEESACLKAALEANERVVLPHAGLFADGTAVAQIGALPFDIVRLRKSDNSGPIVEPDIVTVNTDEICAAIKDTFDENRSIVEPSGAMALAGIKKYVAEHKISGKNMVSIVCGANMNFDRLRYIAERTELGEQREAIYAVTLSEEKGAFLGFCRALQGRNITEFNYRANNTEEAQVFVGISLKGGDTERHEILEQLKQQNYVVDDLSDDEVAKLHIRYLIGGHANLDDERLFRVEFPERPGALLTFLTRLGPTHNITLFHYRNHGAAEGRVLVGLQATDAKQNPDGLIETLEQISYPYAEITDNVGYKRFLK
Atome Classification :
(25 SA)
.........--10.....--...20........30.....---------------...40........50........60........---70........80........90........100.......110.......120.......130.-...-.-.-.140.......150.......160.....----..170---........180.......190...-..-....200---....-...210.....--..220-........230.......240.......250.......260.......270.......280.......290.-----.-....-----.-----300---..--.--..--....310.-..-....320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420....-..-.430.......440.......450.......460.......470.......480.......490.......500.......510.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
L
S
R
V
V
R
Q
I
--
L
Q
A
T
V
Y
D
--
V
A
IETPLEAA
P
R
I
S
Q
K
L
N
N
T
---------------
I
R
F
K
R
EDLQ
P
V
F
S
F
K
L
R
G
A
Y
N
R
I
S
QL
P
K
E
Q
L
ER---
G
V
I
CASAGNHAQ
G
V
A
LSGQRLGI
P
A
I
I
V
MPSTTP
D
I
K
V
Q
A
V
K
RLG
G
Q
V
V
L
HGDS
F
D
I
A
N
K
Y
A
Q
Q
-RAE-A-E-
G
L
V
F
IPPYDD
E
L
V
I
AGQ
G
T
I
A
N
E
I
L
R
QWR----D
V
E
Y
----
V
F
V
A
VGG
G
G
L
I
A
G
V
A
A
Y
L
G--DVA-P
H
-
V
K
V
I
G
V
E---YE
E
S
-
A
C
L
K
A
A
LEAN
E
--
R
V
V
-L-PHAGLFADGT
A
V
A
QIGAL
P
F
D
I
V
R
L
RKSDNSGPIVEP
D
I
V
T
V
N
T
D
E
I
C
A
A
I
K
D
T
FDENRSIVEPSG
A
M
A
L
A
G
-----
I
-
K
K
Y
V
-----
A
-----
E
-----HK--I--SG--K
N
M
V
S
I
V
C-GA-NM
N
F
D
R
L
R
Y
I
A
E
R
T
ELGEQR
E
A
I
Y
A
V
T
LSEEK
G
A
F
L
G
F
C
R
A
LQGRNI
T
E
F
N
YRANNTE
E
A
Q
V
F
V
G
I
S
LKGGD
T
E
R
H
E
I
L
E
Q
L
K
QQN
Y
V
VDDLSDDE
V
A
K
L
H
I
R
Y
L
IGGHAN-L
D
-
D
E
R
L
F
R
V
EFPERP
G
A
L
L
T
F
L
T
RLGPTH
N
I
T
L
F
H
YRNHGAAE
G
R
V
L
V
G
L
QATDAKQN
P
D
G
L
I
E
T
L
E
Q
ISY
P
Y
A
E
ITDNVG
Y
K
R
FLK
31
HHSearch
90.34
52%
-94
- C2 -
-
1TDJ
1
ILVA_ECOLI
A:
[13-513]
-
G
A
E
Y
L
R
A
V
--
L
R
A
P
V
Y
E
--
A
A
Q
V
T
P
L
Q
K
M
E
K
L
S
S
R
L
D
N
V
---------------
I
L
V
K
R
E
D
R
Q
P
V
H
S
F
K
L
R
G
A
Y
A
M
M
A
G
L
T
E
E
Q
K
A
H
---
G
V
I
T
A
S
A
G
N
H
A
Q
G
V
A
F
S
S
A
R
L
G
V
K
A
L
I
V
M
P
T
A
T
A
D
I
K
V
D
A
V
R
G
F
G
G
E
V
L
L
H
G
A
N
F
D
E
A
K
A
K
A
I
E
-
L
S
Q
-
Q
-
Q
-
G
F
T
W
V
P
P
F
D
H
P
M
V
I
A
G
Q
G
T
L
A
L
E
L
L
Q
Q
D
A
----
H
L
D
R
----
V
F
V
P
V
G
G
G
G
L
A
A
G
V
A
V
L
I
K
--
Q
L
M
-
P
Q
-
I
K
V
I
A
V
E
---
A
E
D
S
-
A
C
L
K
A
A
L
D
A
G
H
--
P
V
D
-
L
-
P
R
V
G
L
F
A
E
G
V
A
V
K
R
I
G
D
E
T
F
R
L
C
Q
E
Y
---------
L
D
D
I
I
T
V
D
S
D
A
I
C
A
A
M
K
D
L
F
E
D
V
R
A
V
A
E
P
S
G
A
L
A
L
A
G
-----
M
-
K
K
Y
I
-----
A
-----
L
-----
H
N
--
I
--
R
G
--
E
R
L
A
H
I
L
S
-
G
A
-
N
V
N
F
H
G
L
R
Y
V
S
E
R
C
E
L
G
E
Q
R
E
A
L
L
A
V
T
I
P
E
E
K
G
S
F
L
K
F
C
Q
L
L
G
G
R
S
V
T
E
F
N
Y
R
F
A
D
A
K
N
A
C
I
F
V
G
V
R
L
S
R
G
L
E
E
R
K
E
I
L
Q
M
L
N
D
G
G
Y
S
V
V
D
L
S
D
D
E
M
A
K
L
H
V
R
Y
M
V
G
G
R
P
S
H
P
L
-
Q
E
R
L
Y
S
F
E
F
P
E
S
P
G
A
L
L
R
F
L
N
T
L
G
T
Y
W
N
I
S
L
F
H
Y
R
S
H
G
T
D
Y
G
R
V
L
A
A
F
E
-------------------
Y
D
C
H
D
E
T
N
N
P
A
F
R
F
F
L
A
1
PsiBlast_PDB
88.88
51%
-96
- C2 -
-
1TDJ
1
ILVA_ECOLI
A:
[17-512]
-----
L
R
A
V
--
L
R
A
P
V
Y
E
--
A
A
Q
V
T
P
L
Q
K
M
E
K
L
S
S
R
L
D
N
V
---------------
I
L
V
K
R
E
D
R
Q
P
V
H
S
F
K
L
R
G
A
Y
A
M
M
A
G
L
T
E
E
Q
K
A
H
---
G
V
I
T
A
S
A
G
N
H
A
Q
G
V
A
F
S
S
A
R
L
G
V
K
A
L
I
V
M
P
T
A
T
A
D
I
K
V
D
A
V
R
G
F
G
G
E
V
L
L
H
G
A
N
F
D
E
A
K
A
K
A
I
E
-
L
S
Q
-
Q
-
Q
-
G
F
T
W
V
P
P
F
D
H
P
M
V
I
A
G
Q
G
T
L
A
L
E
L
L
Q
Q
D
A
----
H
L
D
R
----
V
F
V
P
V
G
G
G
G
L
A
A
G
V
A
V
L
I
K
--
Q
L
M
-
P
Q
-
I
K
V
I
A
V
E
---
A
E
D
S
-
A
C
L
K
A
A
L
D
A
G
H
--
P
V
D
-
L
-
P
R
V
G
L
F
A
E
G
V
A
V
K
R
I
G
D
E
T
F
R
L
C
Q
E
Y
L
D
---------
D
I
I
T
V
D
S
D
A
I
C
A
A
M
K
D
L
F
E
D
V
R
A
V
A
E
P
S
G
A
L
A
L
A
G
-----
M
-
K
K
Y
I
-----
A
-----
L
-----
H
N
--
I
--
R
G
--
E
R
L
A
H
I
L
S
-
G
A
-
N
V
N
F
H
G
L
R
Y
V
S
E
R
C
E
L
G
E
Q
R
E
A
L
L
A
V
T
I
P
E
E
K
G
S
F
L
K
F
C
Q
L
L
G
G
R
S
V
T
E
F
N
Y
R
F
A
D
A
K
N
A
C
I
F
V
G
V
R
L
S
R
G
L
E
E
R
K
E
I
L
Q
M
L
N
D
G
G
Y
S
V
V
D
L
S
D
D
E
M
A
K
L
H
V
R
Y
M
V
G
G
R
P
S
-
H
P
L
Q
E
R
L
Y
S
F
E
F
P
E
S
P
G
A
L
L
R
F
L
N
T
L
G
T
Y
W
N
I
S
L
F
H
Y
R
S
H
G
T
D
Y
G
R
V
L
A
A
F
E
-------------------
Y
D
C
H
D
E
T
N
N
P
A
F
R
F
F
L
-
33
HHSearch
73.88
51%
-103
- C2 -
-
3IAU
-
THD1_SOLLC
B:
[43-362]
--
F
Q
Y
L
V
D
I
--
L
A
S
P
V
Y
D
--
V
A
I
E
S
P
L
E
L
A
E
K
L
S
D
R
L
G
V
N
---------------
F
Y
I
K
R
E
D
K
Q
R
V
F
S
F
K
L
R
G
A
Y
N
M
M
S
N
L
S
R
E
E
L
D
K
---
G
V
I
T
A
S
A
G
N
H
A
Q
G
V
A
L
A
G
Q
R
L
N
C
V
A
K
I
V
M
P
T
T
T
P
Q
I
K
I
D
A
V
R
A
L
G
G
D
V
V
L
Y
G
K
T
F
D
E
A
Q
T
H
A
L
E
-
L
S
E
-
K
-
D
-
G
L
K
Y
I
P
P
F
D
D
P
G
V
I
K
G
Q
G
T
I
G
T
E
I
N
R
Q
L
K
----
D
I
H
A
----
V
F
I
P
V
G
G
G
G
L
I
A
G
V
A
T
F
F
K
--
Q
I
A
-
P
N
-
T
K
I
I
G
V
E
---
P
Y
G
A
-
A
S
M
T
L
S
L
H
E
G
H
--
R
V
K
-
L
-
S
N
V
D
T
F
A
D
G
V
A
V
A
L
V
G
E
Y
T
F
A
K
C
Q
E
L
---------
I
D
G
M
V
L
V
A
N
D
G
I
S
A
A
I
K
D
V
Y
D
E
G
R
N
I
L
E
T
S
G
A
V
A
I
A
G
-----
A
-
A
A
Y
C
-----
E
-----
F
-----
Y
K
--
I
--
K
N
--
E
N
I
V
A
I
A
S
-
G
A
-
N
M
D
F
S
K
L
H
K
V
T
E
L
A
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
73.69
51%
-105
- C2 -
-
3IAU
1
THD1_SOLLC
A:
[43-363]
--
F
Q
Y
L
V
D
I
--
L
A
S
P
V
Y
D
--
V
A
I
E
S
P
L
E
L
A
E
K
L
S
D
R
L
G
V
N
---------------
F
Y
I
K
R
E
D
K
Q
R
V
F
S
F
K
L
R
G
A
Y
N
M
M
S
N
L
S
R
E
E
L
D
K
---
G
V
I
T
A
S
A
G
N
H
A
Q
G
V
A
L
A
G
Q
R
L
N
C
V
A
K
I
V
M
P
T
T
T
P
Q
I
K
I
D
A
V
R
A
L
G
G
D
V
V
L
Y
G
K
T
F
D
E
A
Q
T
H
A
L
E
-
L
S
E
-
K
-
D
-
G
L
K
Y
I
P
P
F
D
D
P
G
V
I
K
G
Q
G
T
I
G
T
E
I
N
R
Q
L
K
----
D
I
H
A
----
V
F
I
P
V
G
G
G
G
L
I
A
G
V
A
T
F
F
K
--
Q
I
A
-
P
N
-
T
K
I
I
G
V
E
---
P
Y
G
A
-
A
S
M
T
L
S
L
H
E
G
H
--
R
V
K
-
L
-
S
N
V
D
T
F
A
D
G
V
A
V
A
L
V
G
E
Y
T
F
A
K
C
Q
E
L
---------
I
D
G
M
V
L
V
A
N
D
G
I
S
A
A
I
K
D
V
Y
D
E
G
R
N
I
L
E
T
S
G
A
V
A
I
A
G
-----
A
-
A
A
Y
C
-----
E
-----
F
-----
Y
K
--
I
--
K
N
--
E
N
I
V
A
I
A
S
-
G
A
-
N
M
D
F
S
K
L
H
K
V
T
E
L
A
G
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
73.46
49%
-103
- C2 -
-
3IAU
1
THD1_SOLLC
A:
[42-363]
-
L
F
Q
Y
L
V
D
I
--
L
A
S
P
V
Y
D
--
V
A
I
E
S
P
L
E
L
A
E
K
L
S
D
R
L
G
V
N
---------------
F
Y
I
K
R
E
D
K
Q
R
V
F
S
F
K
L
R
G
A
Y
N
M
M
S
N
L
S
R
E
E
L
D
K
---
G
V
I
T
A
S
A
G
N
H
A
Q
G
V
A
L
A
G
Q
R
L
N
C
V
A
K
I
V
M
P
T
T
T
P
Q
I
K
I
D
A
V
R
A
L
G
G
D
V
V
L
Y
G
K
T
F
D
E
A
Q
T
H
A
L
E
-
L
S
E
-
K
-
D
-
G
L
K
Y
I
P
P
F
D
D
P
G
V
I
K
G
Q
G
T
I
G
T
E
I
N
R
Q
L
K
----
D
I
H
A
----
V
F
I
P
V
G
G
G
G
L
I
A
G
V
A
T
F
F
K
--
Q
I
A
-
P
N
-
T
K
I
I
G
V
E
---
P
Y
G
A
-
A
S
M
T
L
S
L
H
E
G
H
--
R
V
K
-
L
-
S
N
V
D
T
F
A
D
G
V
A
V
A
L
V
G
E
Y
T
F
--
A
K
C
Q
E
L
I
D
G
-------
M
V
L
V
A
N
D
G
I
S
A
A
I
K
D
V
Y
D
E
G
R
N
I
L
E
T
S
G
A
V
A
I
A
G
-----
A
-
A
A
Y
C
-----
E
-----
F
-----
Y
K
--
I
--
K
N
--
E
N
I
V
A
I
A
S
-
G
A
-
N
M
D
F
S
K
L
H
K
V
T
E
L
A
G
L
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.10
35%
-98
- C2 -
-
1V71
1
SRR_SCHPO
A:
[24-316]
---------------------
A
N
K
T
P
V
L
T
S
S
T
V
N
K
E
F
V
A
E
---------------
V
F
F
K
C
E
N
F
Q
K
M
G
A
F
K
F
R
G
A
L
N
A
L
S
Q
L
N
E
A
Q
R
K
A
---
G
V
L
T
F
S
S
G
N
H
A
Q
A
I
A
L
S
A
K
I
L
G
I
P
A
K
I
I
M
P
L
D
A
P
E
A
K
V
A
A
T
K
G
Y
G
G
Q
V
I
M
Y
D
R
Y
K
D
D
R
E
K
M
A
K
E
-
I
S
E
-
R
-
E
-
G
L
T
I
I
P
P
Y
D
H
P
H
V
L
A
G
Q
G
T
A
A
K
E
L
F
E
E
V
G
----
P
L
D
A
----
L
F
V
C
L
G
G
G
G
L
L
S
G
S
A
L
A
A
R
--
H
F
A
-
P
N
-
C
E
V
Y
G
V
E
---
P
E
A
G
-
N
D
G
Q
Q
S
F
R
K
G
S
--
I
V
H
-
I
-
D
T
P
K
T
I
A
D
G
A
Q
T
Q
H
L
G
N
Y
T
F
S
I
I
K
-
E
K
V
D
--------
D
I
L
T
V
S
D
E
E
L
I
D
C
L
K
F
Y
A
A
R
M
K
I
V
V
E
P
T
G
C
L
S
F
A
A
-----
A
-
R
--
A
-----
M
-----
K
-----
E
K
--
L
--
K
N
--
K
R
I
G
I
I
I
S
-
G
G
-
N
V
D
I
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
61.33
35%
-96
- C2 -
-
1WTC
2
SRR_SCHPO
A:
[24-316]
---------------------
A
N
K
T
P
V
L
T
S
S
T
V
N
K
E
F
V
A
E
---------------
V
F
F
K
C
E
N
F
Q
K
M
G
A
F
K
F
R
G
A
L
N
A
L
S
Q
L
N
E
A
Q
R
K
A
---
G
V
L
T
F
S
S
G
N
H
A
Q
A
I
A
L
S
A
K
I
L
G
I
P
A
K
I
I
M
P
L
D
A
P
E
A
K
V
A
A
T
K
G
Y
G
G
Q
V
I
M
Y
D
R
Y
K
D
D
R
E
K
M
A
K
E
-
I
S
E
-
R
-
E
-
G
L
T
I
I
P
P
Y
D
H
P
H
V
L
A
G
Q
G
T
A
A
K
E
L
F
E
E
V
G
----
P
L
D
A
----
L
F
V
C
L
G
G
G
G
L
L
S
G
S
A
L
A
A
R
--
H
F
A
-
P
N
-
C
E
V
Y
G
V
E
---
P
E
A
G
-
N
D
G
Q
Q
S
F
R
K
G
S
--
I
V
H
-
I
-
D
T
P
K
T
I
A
D
G
A
Q
T
Q
H
L
G
N
Y
T
F
S
I
I
K
-
E
K
V
D
--------
D
I
L
T
V
S
D
E
E
L
I
D
C
L
K
F
Y
A
A
R
M
K
I
V
V
E
P
T
G
C
L
S
F
A
A
-----
A
-
R
--
A
-----
M
-----
K
-----
E
K
--
L
--
K
N
--
K
R
I
G
I
I
I
S
-
G
G
-
N
V
D
I
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
61.04
35%
-83
- C2 -
-
2ZPU
1
SRR_SCHPO
A:
[24-316]
---------------------
A
N
K
T
P
V
L
T
S
S
T
V
N
K
E
F
V
A
E
---------------
V
F
F
K
C
E
N
F
Q
K
M
G
A
F
K
F
R
G
A
L
N
A
L
S
Q
L
N
E
A
Q
R
K
A
---
G
V
L
T
F
S
S
G
N
H
A
Q
A
I
A
L
S
A
K
I
L
G
I
P
A
K
I
I
M
P
L
D
A
P
E
A
K
V
A
A
T
K
G
Y
G
G
Q
V
I
M
Y
D
R
Y
K
D
D
R
E
K
M
A
K
E
-
I
S
E
-
R
-
E
-
G
L
T
I
I
P
P
Y
D
H
P
H
V
L
A
G
Q
G
T
A
A
K
E
L
F
E
E
V
G
----
P
L
D
A
----
L
F
V
C
L
G
G
G
G
L
L
S
G
S
A
L
A
A
R
--
H
F
A
-
P
N
-
C
E
V
Y
G
V
E
---
P
E
A
G
-
N
D
G
Q
Q
S
F
R
K
G
S
--
I
V
H
-
I
-
D
T
P
K
T
I
A
D
G
A
Q
T
Q
H
L
G
N
Y
T
F
S
I
I
K
-
E
K
V
D
--------
D
I
L
T
V
S
D
E
E
L
I
D
C
L
K
F
Y
A
A
R
M
K
I
V
V
E
P
T
G
C
L
S
F
A
A
-----
A
-
R
--
A
-----
M
-----
K
-----
E
K
--
L
--
K
N
--
K
R
I
G
I
I
I
S
-
G
G
-
N
V
D
I
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
60.54
35%
-81
- C2 -
-
2ZR8
1
SRR_SCHPO
A:
[24-316]
---------------------
A
N
K
T
P
V
L
T
S
S
T
V
N
K
E
F
V
A
E
---------------
V
F
F
K
C
E
N
F
Q
K
M
G
A
F
K
F
R
G
A
L
N
A
L
S
Q
L
N
E
A
Q
R
K
A
---
G
V
L
T
F
S
S
G
N
H
A
Q
A
I
A
L
S
A
K
I
L
G
I
P
A
K
I
I
M
P
L
D
A
P
E
A
K
V
A
A
T
K
G
Y
G
G
Q
V
I
M
Y
D
R
Y
K
D
D
R
E
K
M
A
K
E
-
I
S
E
-
R
-
E
-
G
L
T
I
I
P
P
Y
D
H
P
H
V
L
A
G
Q
G
T
A
A
K
E
L
F
E
E
V
G
----
P
L
D
A
----
L
F
V
C
L
G
G
G
G
L
L
S
G
S
A
L
A
A
R
--
H
F
A
-
P
N
-
C
E
V
Y
G
V
E
---
P
E
A
G
-
N
D
G
Q
Q
S
F
R
K
G
S
--
I
V
H
-
I
-
D
T
P
K
T
I
A
D
G
A
Q
T
Q
H
L
G
N
Y
T
F
S
I
I
K
-
E
K
V
D
--------
D
I
L
T
V
S
D
E
E
L
I
D
C
L
K
F
Y
A
A
R
M
K
I
V
V
E
P
T
G
C
L
S
F
A
A
-----
A
-
R
--
A
-----
M
-----
K
-----
E
K
--
L
--
K
N
--
K
R
I
G
I
I
I
S
-
G
G
-
N
V
D
I
E
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
57.11
31%
-89
- C2 -
-
5CVC
1
?
A:
[26-336]
-----------
A
Q
A
R
I
A
P
--
Y
V
H
R
T
P
V
M
S
S
T
S
I
D
A
M
V
G
K
K
---------------
L
F
F
K
C
E
C
F
Q
K
A
G
A
F
K
I
R
G
A
S
N
S
I
F
A
L
D
D
E
Q
V
S
K
---
G
V
V
T
H
S
S
G
N
H
A
A
A
V
A
L
A
A
K
L
R
G
I
P
A
H
I
V
I
P
R
N
A
P
A
S
K
V
E
N
V
K
C
Y
G
G
H
I
I
W
S
D
A
S
I
E
S
R
E
Y
V
S
K
R
-
V
Q
E
-
E
-
T
-
G
A
V
L
I
H
P
I
N
S
K
Y
T
I
S
G
Q
G
T
V
S
L
E
L
L
E
Q
V
P
----
E
I
D
T
----
I
I
V
P
I
S
G
G
G
L
I
S
G
V
A
L
A
A
K
--
A
I
N
-
P
S
-
I
R
I
L
A
A
E
---
P
K
G
A
-
D
D
S
A
Q
S
K
A
A
G
K
--
I
I
T
-
L
-
P
S
T
N
T
I
A
D
G
L
R
A
F
-
L
G
D
L
T
W
P
V
V
R
D
L
---------
V
D
D
V
I
V
V
D
D
T
A
I
V
D
A
M
K
M
C
Y
E
I
L
K
V
A
V
E
P
S
G
A
I
G
L
A
A
-----
A
-
L
S
D
E
-----
F
-----
K
Q
S---
S
A
--
W
H
-
E
S
--
S
K
I
G
I
I
V
S
-
G
G
-
N
V
D
L
G
T
L
W
Q
S
M
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
56.10
29%
-61
- C2 -
-
3L6B
1
SRR_HUMAN
A:
[15-327]
-----------
A
H
I
N
I
R
D
--
S
I
H
L
T
P
V
L
T
S
S
I
L
N
Q
L
T
G
R
N
---------------
L
F
F
K
C
E
L
F
Q
K
T
G
S
F
K
I
R
G
A
L
N
A
V
R
S
L
V
--
R
K
P
K
---
A
V
V
T
H
S
S
G
N
H
G
Q
A
L
T
Y
A
A
K
L
E
G
I
P
A
Y
I
V
V
P
Q
T
A
P
D
C
K
K
L
A
I
Q
A
Y
G
A
S
I
V
Y
C
E
P
S
D
E
S
R
E
N
V
A
K
R
-
V
T
E
-
E
-
T
-
E
G
I
M
V
H
P
N
Q
E
P
A
V
I
A
G
Q
G
T
I
A
L
E
V
L
N
Q
V
P
----
L
V
D
A
----
L
V
V
P
V
G
G
G
G
M
L
A
G
I
A
I
T
V
K
--
A
L
K
-
P
S
-
V
K
V
Y
A
A
E
---
P
S
N
A
-
D
D
C
Y
Q
S
K
L
K
G
K
--
L
M
P
N
L
-
Y
P
P
E
T
I
A
D
G
V
K
S
S
-
I
G
L
N
T
W
P
I
I
R
D
L
---------
V
D
D
I
F
T
V
T
E
D
E
I
K
C
A
T
Q
L
V
W
E
R
M
K
L
L
I
E
P
T
A
G
V
G
V
A
A
-----
V
-
L
S
Q
H
-----
F
-----
Q
-----
T
V
S-
P
--
E
V
--
K
N
I
C
I
V
L
S
-
G
G
-
N
V
D
L
T
S
S
I
T
W
V
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
53.19
32%
-52
- C2 -
-
2RKB
1
SDSL_HUMAN
D:
[4-314]
--------------------
F
H
V
V
T
P
L
L
E
S
W
A
L
S
Q
V
A
G
M
P
---------------
V
F
L
K
C
E
N
V
Q
P
S
G
S
F
K
I
R
G
I
G
H
F
C
Q
E
M
A
K
-
K
G
C
R
---
H
L
V
C
S
S
G
G
N
A
G
I
A
A
A
Y
A
A
R
K
L
G
I
P
A
T
I
V
L
P
E
S
T
S
L
Q
V
V
Q
R
L
Q
G
E
G
A
E
V
Q
L
T
G
K
V
W
D
E
A
N
L
R
A
Q
E
-
L
A
K
-
R
-
D
-
G
W
E
N
V
P
P
F
D
H
P
L
I
W
K
G
H
A
S
L
V
Q
E
L
K
A
V
L
R
T---
P
P
G
A
----
L
V
L
A
V
G
G
G
G
L
L
A
G
V
V
A
G
L
L
--
E
V
G
W
Q
H
-
V
P
I
I
A
M
E
---
T
H
G
A
-
H
C
F
N
A
A
I
T
A
G
K
--
L
V
T
-
L
-
P
D
I
T
S
V
A
K
S
L
G
A
K
T
V
A
A
R
A
L
E
C
M
Q
V
C
---------
K
I
H
S
E
V
V
E
D
T
E
A
V
S
A
V
Q
Q
L
L
D
D
E
R
M
L
V
E
P
A
C
G
A
A
L
A
A
-----
I
-
Y
S
G
L
-----
L
-----
R
RLQAE
G
C
--
L
PP
S
L
--
T
S
V
V
V
I
V
C
-
G
G
N
N
I
N
S
R
E
L
Q
A
L
K
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
52.46
29%
-37
- C2 -
-
1PWH
1
SDHL_RAT
A:
[3-322]
--------------
A
Q
E
S
--
L
H
V
K
T
P
L
R
D
S
M
A
L
S
K
V
A
G
T
S
---------------
V
F
L
K
M
D
S
S
Q
P
S
G
S
F
K
I
R
G
I
G
H
L
C
K
M
K
A
-
K
Q
G
C
K
---
H
F
V
C
S
S
A
G
N
A
G
M
A
T
A
Y
A
A
R
R
L
G
L
P
A
T
I
V
V
P
S
T
T
P
A
L
T
I
E
R
L
K
N
E
G
A
T
V
E
V
V
G
E
M
L
D
E
A
I
Q
L
A
K
A
-
L
E
K
N
N
-
P
-
G
W
V
Y
I
S
P
F
D
D
P
L
I
W
E
G
H
T
S
L
V
K
E
L
K
E
T
L
S
A---
K
P
G
A
----
I
V
L
S
V
G
G
G
G
L
L
C
G
V
V
Q
G
L
R
--
E
V
G
W
E
D
-
V
P
I
I
A
M
E
---
T
F
G
A
-
H
S
F
H
A
A
V
K
E
G
K
--
L
V
T
-
L
-
P
K
I
T
S
V
A
K
A
L
G
V
N
T
V
G
A
Q
T
L
K
L
F
Y
E
H
---------
P
I
F
S
E
V
I
S
D
Q
E
A
V
T
A
I
E
K
F
V
D
D
E
K
I
L
V
E
P
A
C
G
A
A
L
A
A
-----
V
-
Y
S
G
V
-----
V
C
R
L
Q
A
E
-----
A
R
LQ
T
--
P
L
--
A
S
L
V
V
I
V
C
-
G
G
S
N
I
S
L
A
Q
L
Q
A
L
K
A
Q
L
G
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
52.09
30%
-41
- C2 -
-
4H27
-
SDHL_HUMAN
A:
[41-358]
----------------
E
P
--
L
H
V
K
T
P
I
R
D
S
M
A
L
S
K
M
A
G
T
S
---------------
V
Y
L
K
M
D
S
A
Q
P
S
G
S
F
K
I
R
G
I
G
H
F
C
K
R
W
A
K
-
Q
G
C
A
---
H
F
V
C
S
S
S
G
N
A
G
M
A
A
A
Y
A
A
R
Q
L
G
V
P
A
T
I
V
V
P
G
T
T
P
A
L
T
I
E
R
L
K
N
E
G
A
T
V
K
V
V
G
E
L
L
D
E
A
F
E
L
A
K
A
-
L
A
K
-
N
N
P
-
G
W
V
Y
I
P
P
F
D
D
P
L
I
W
E
G
H
A
S
I
V
K
E
L
K
E
T
L
W
E---
K
P
G
A
----
I
A
L
S
V
G
G
G
G
L
L
C
G
V
V
Q
G
L
Q
--
E
V
G
W
G
D
-
V
P
V
I
A
M
E
---
T
F
G
A
-
H
S
F
H
A
A
T
T
A
G
K
--
L
V
S
-
L
-
P
K
I
T
S
V
A
K
A
L
G
V
K
T
V
G
A
Q
A
L
K
L
F
Q
E
H
---------
P
I
F
S
E
V
I
S
D
Q
E
A
V
A
A
I
E
K
F
V
D
D
E
K
I
L
V
E
P
A
C
G
A
A
L
A
A
-----
V
-
Y
S
H
V
-----
I
-----
Q
K
L
Q
L
E
G
N
LR
T
--
P
L
--
P
S
L
V
V
I
V
C
-
G
G
S
N
I
S
L
A
Q
L
R
A
L
K
E
Q
L
G
-
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
51.76
33%
7
- C2 -
-
2ZPU
1
SRR_SCHPO
A:
[7-321]
--
L
P
T
Y
D
D
V
A
S
A
S
E
R
I
K
K
--
F
A
N
K
T
P
V
L
T
S
S
T
V
N
K
E
F
V
A
E
---------------
V
F
F
K
C
E
N
F
Q
K
M
G
A
F
K
F
R
G
A
L
N
A
L
S
Q
L
N
E
A
Q
R
K
A
---
G
V
L
T
F
S
S
G
N
H
A
Q
A
I
A
L
S
A
K
I
L
G
I
P
A
K
I
I
M
P
L
D
A
P
E
A
K
V
A
A
T
K
G
Y
G
G
Q
V
I
M
Y
D
R
Y
K
D
D
R
E
K
M
A
K
E
-
I
S
E
-
R
-
E
-
G
L
T
I
I
P
P
Y
D
H
P
H
V
L
A
G
Q
G
T
A
A
K
E
L
F
E
E
V
G
----
P
L
D
A
----
L
F
V
C
L
G
G
G
G
L
L
S
G
S
A
L
A
A
R
--
H
F
A
-
P
N
-
C
E
V
Y
G
V
E
---
P
E
A
G
-
N
D
G
Q
Q
S
F
R
K
G
S
--
I
V
H
-
I
-
D
T
P
K
T
I
A
D
G
A
Q
T
Q
H
L
G
N
Y
T
F
S
I
I
K
E
K
---------
V
D
D
I
L
T
V
S
D
E
E
L
I
D
C
L
K
F
Y
A
A
R
M
K
I
V
V
E
P
T
G
C
L
S
F
A
A
-----
A
-
R
A
M
K
-----
E
-----
K
-----
L
------
K
N
--
K
R
I
G
I
I
I
S
-
G
G
-
N
V
D
I
E
R
Y
A
H
F
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
51.23
39%
14
- C2 -
-
2GN0
-
TDCB_SALTY
A:
[18-337]
----------------
Y
D
LP
V
A
I
E
D
I
L
E
A
K
K
R
L
A
G
K
I
Y
K
T
G
M
P
R
S
N
Y
F
S
E
R
C
K
G
E
I
F
L
K
F
E
N
M
Q
R
T
G
S
F
K
I
R
G
A
F
N
K
L
S
S
L
T
E
A
E
K
R
K
---
G
V
V
A
C
S
A
G
N
H
A
Q
G
V
S
L
S
C
A
M
L
G
I
D
G
K
V
V
M
P
K
G
A
P
K
S
K
V
A
A
T
C
D
Y
S
A
E
V
V
L
H
G
D
N
F
N
D
T
I
A
K
V
S
E
-
I
V
E
-
T
-
E
-
G
R
I
F
I
P
P
Y
D
D
P
K
V
I
A
G
Q
G
T
I
G
L
E
I
M
E
D
L
Y
----
D
V
D
N
----
V
I
V
P
I
G
G
G
G
L
I
A
G
I
A
I
A
I
K
--
S
I
N
-
P
T
-
I
K
V
I
G
V
Q
---
A
E
N
V
-
H
G
M
A
A
S
Y
Y
T
G
E
--
I
T
T
-
H
-
R
T
T
G
T
L
A
D
G
C
D
V
S
R
P
G
N
L
T
Y
E
I
V
R
--------
E
L
V
D
-
D
I
V
L
V
S
E
D
E
I
R
N
S
M
I
A
L
I
Q
R
N
K
V
I
T
E
G
A
G
A
L
A
C
A
A
-----
L
-
L
S
G
K
-----
L
-----
D
-----
S
H
--
I
--
Q
N
--
R
K
T
V
S
I
I
S
-
G
G
-
N
I
D
L
S
R
V
S
Q
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
51.04
31%
-23
- C2 -
-
3L6B
1
SRR_HUMAN
A:
[26-319]
------------------------
T
P
V
L
T
S
S
I
L
N
Q
L
T
G
R
N
---------------
L
F
F
K
C
E
L
F
Q
K
T
G
S
F
K
I
R
G
A
L
N
A
V
R
S
L
V
-----
R
KPK
A
V
V
T
H
S
S
G
N
H
G
Q
A
L
T
Y
A
A
K
L
E
G
I
P
A
Y
I
V
V
P
Q
T
A
P
D
C
K
K
L
A
I
Q
A
Y
G
A
S
I
V
Y
C
E
P
S
D
E
S
R
E
N
V
A
K
R
-
V
T
E
-
E
-
T
-
E
G
I
M
V
H
P
N
Q
E
P
A
V
I
A
G
Q
G
T
I
A
L
E
V
L
N
Q
V
P
----
L
V
D
A
----
L
V
V
P
V
G
G
G
G
M
L
A
G
I
A
I
T
V
K
--
A
L
K
-
P
S
-
V
K
V
Y
A
A
E
---
P
S
N
A
D
D
C
Y
Q
S
K
L
K
G
K
L
--
M
P
N
-
L
-
Y
P
P
E
T
I
A
D
G
V
K
-
S
S
I
G
L
N
T
W
P
I
I
R
--------
D
L
V
D
-
D
I
F
T
V
T
E
D
E
I
K
C
A
T
Q
L
V
W
E
R
M
K
L
L
I
E
P
T
A
G
V
G
V
A
A
-----
V
L
S
Q
H
F
-----
Q
-----
T
-----
V
S
--
P
--
E
V
--
K
N
I
C
I
V
L
S
-
G
G
-
N
V
D
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.81
26%
-36
- C2 -
-
1PWH
1
SDHL_RAT
A:
[9-324]
----------------------
V
K
T
P
L
R
D
S
M
A
L
S
K
V
A
G
T
S
---------------
V
F
L
K
M
D
S
S
Q
P
S
G
S
F
K
I
R
G
-
I
G
H
L
C
K
M
K
A
K
Q
G
C
K
---
H
F
V
C
S
S
A
G
N
A
G
M
A
T
A
Y
A
A
R
R
L
G
L
P
A
T
I
V
V
P
S
T
T
P
A
L
T
I
E
R
L
K
N
E
G
A
T
V
E
V
V
G
E
M
L
D
E
A
I
Q
L
A
K
A
L
E
K
N
-
N
-
P
-
G
W
V
Y
I
S
P
F
D
D
P
L
I
W
E
G
H
T
S
L
V
K
E
-
L
K
E
T
L
----
S
A
K
P
----
G
A
I
V
L
S
V
G
G
G
G
L
L
C
G
V
V
Q
G
L
R
E
V
G
-
W
E
D
V
P
I
I
A
M
E
---
T
F
G
A
-
H
S
F
H
A
A
V
K
E
G
K
--
L
V
T
-
L
-
P
K
I
T
S
V
A
K
A
L
G
V
N
T
V
G
A
Q
T
L
K
L
F
Y
------
E
H
P
I
F
S
E
---
V
I
S
D
Q
E
A
V
T
A
I
E
K
F
V
D
D
E
K
I
L
V
E
P
A
C
G
A
A
L
A
A
-----
V
-
Y
S
G
V
V
C
R
L
Q
A
-----
E
-----
A
R
--
L
--
Q
T
PL
A
S
L
V
V
I
V
C
G
G
S
-
N
I
S
L
A
Q
L
Q
A
L
K
A
Q
L
G
L
N
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
50.79
39%
13
- C2 -
-
2GN1
-
TDCB_SALTY
A:
[18-337]
----------------
Y
D
LP
V
A
I
E
D
I
L
E
A
K
K
R
L
A
G
K
I
Y
K
T
G
M
P
R
S
N
Y
F
S
E
R
C
K
G
E
I
F
L
K
F
E
N
M
Q
R
T
G
S
F
K
I
R
G
A
F
N
K
L
S
S
L
T
E
A
E
K
R
K
---
G
V
V
A
C
S
A
G
N
H
A
Q
G
V
S
L
S
C
A
M
L
G
I
D
G
K
V
V
M
P
K
G
A
P
K
S
K
V
A
A
T
C
D
Y
S
A
E
V
V
L
H
G
D
N
F
N
D
T
I
A
K
V
S
E
-
I
V
E
-
T
-
E
-
G
R
I
F
I
P
P
Y
D
D
P
K
V
I
A
G
Q
G
T
I
G
L
E
I
M
E
D
L
Y
----
D
V
D
N
----
V
I
V
P
I
G
G
G
G
L
I
A
G
I
A
I
A
I
K
--
S
I
N
-
P
T
-
I
K
V
I
G
V
Q
---
A
E
N
V
-
H
G
M
A
A
S
Y
Y
T
G
E
--
I
T
T
-
H
-
R
T
T
G
T
L
A
D
G
C
D
V
S
R
P
G
N
L
T
Y
E
I
V
R
--------
E
L
V
D
-
D
I
V
L
V
S
E
D
E
I
R
N
S
M
I
A
L
I
Q
R
N
K
V
I
T
E
G
A
G
A
L
A
C
A
A
-----
L
-
L
S
G
K
-----
L
-----
D
-----
S
H
--
I
--
Q
N
--
R
K
T
V
S
I
I
S
-
G
G
-
N
I
D
L
S
R
V
S
Q
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.70
33%
-42
- C2 -
-
5CVC
1
?
A:
[27-331]
------------
Q
A
R
I
A
P
--
Y
V
H
R
T
P
V
M
S
S
T
S
I
D
A
M
V
G
K
K
---------------
L
F
F
K
C
E
C
F
Q
K
A
G
A
F
K
I
R
G
A
S
N
S
I
F
A
L
D
D
E
Q
V
S
K
---
G
V
V
T
H
S
S
G
N
H
A
A
A
V
A
L
A
A
K
L
R
G
I
P
A
H
I
V
I
P
R
N
A
P
A
S
K
V
E
N
V
K
C
Y
G
G
H
I
I
W
S
D
A
S
I
E
-
S
R
E
Y
V
S
K
-
R
V
Q
-
E
-
E
T
G
A
V
L
I
H
P
I
N
S
K
Y
T
I
S
G
Q
G
T
V
S
L
E
L
L
E
Q
V
P
----
E
I
D
T
----
I
I
V
P
I
S
G
G
G
L
I
S
G
V
A
L
A
A
K
--
A
I
N
-
P
S
-
I
R
I
L
A
A
E
P
KG
A
D
D
S
-
A
Q
S
K
A
---
A
G
K
--
I
I
T
-
L
-
P
S
T
N
T
I
A
D
G
L
R
-
A
F
L
G
D
L
T
W
P
V
V
R
D
L
V
D
D
V
I
---------
V
V
D
D
T
A
I
V
D
A
M
K
M
C
Y
E
I
L
K
V
A
V
E
P
S
G
A
I
G
L
A
A
A
L
S
D
E
F
-
K
Q
S
S
-----
A
-----
W
-----
H
E
--
S
--
S
K
--
I
G
I
--
I
V
S
-
G
G
-
N
V
D
L
G
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
50.43
33%
-41
- C2 -
-
5CVC
1
?
B:
[27-331]
------------
Q
A
R
I
A
P
--
Y
V
H
R
T
P
V
M
S
S
T
S
I
D
A
M
V
G
K
K
---------------
L
F
F
K
C
E
C
F
Q
K
A
G
A
F
K
I
R
G
A
S
N
S
I
F
A
L
D
D
E
Q
V
S
K
---
G
V
V
T
H
S
S
G
N
H
A
A
A
V
A
L
A
A
K
L
R
G
I
P
A
H
I
V
I
P
R
---
A
S
K
V
E
N
V
K
C
Y
G
G
H
I
I
W
S
D
A
S
I
E
-
S
R
E
Y
V
S
K
-
R
V
Q
-
E
-
E
T
G
A
V
L
I
H
P
I
N
S
K
Y
T
I
S
G
Q
G
T
V
S
L
E
L
L
E
Q
V
P
----
E
I
D
T
----
I
I
V
P
I
S
G
G
G
L
I
S
G
V
A
L
A
A
K
--
A
I
N
-
P
S
-
I
R
I
L
A
A
E
P
KG
A
D
D
S
-
A
Q
S
K
A
---
A
G
K
--
I
I
T
-
L
-
P
S
T
N
T
I
A
D
G
L
R
-
A
F
L
G
D
L
T
W
P
V
V
R
D
L
V
D
D
V
I
---------
V
V
D
D
T
A
I
V
D
A
M
K
M
C
Y
E
I
L
K
V
A
V
E
P
S
G
A
I
G
L
A
A
A
L
SDE
F
-
K
--------
A
-----
W
-----
H
E
--
S
--
S
K
--
I
G
I
--
I
V
S
-
G
G
-
N
V
D
L
G
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
49.78
34%
-16
- C2 -
-
1VE5
1
?
A:
[10-310]
-----------
A
F
R
R
I
A
P
--
Y
T
H
R
T
P
L
L
T
S
R
L
L
D
G
L
L
G
K
R
---------------
L
L
L
K
A
E
H
L
Q
K
T
G
S
F
K
A
R
G
A
L
S
K
A
L
A
L
E
---
N
P
K
---
G
L
L
A
V
S
S
G
N
H
A
Q
G
V
A
Y
A
A
Q
V
L
G
V
K
A
L
V
V
M
P
E
D
--
P
Y
K
K
A
C
A
R
A
Y
G
A
E
V
V
D
R
G
V
T
A
K
N
R
E
E
V
A
R
A
-
L
Q
E
-
E
-
T
-
G
Y
A
L
I
H
P
F
D
D
P
L
V
I
A
G
Q
G
T
A
G
L
E
L
L
A
Q
A
G
R
M
GV
F
P
G
A
----
V
L
A
P
V
G
G
G
G
L
L
A
G
L
A
T
A
V
K
--
A
L
S
-
P
T
-
T
L
V
L
G
V
E
---
P
E
A
A
-
D
D
A
K
R
S
L
E
A
G
R
--
I
L
R
-
L
E
A
P
P
R
T
R
A
D
G
V
R
T
L
S
L
G
E
R
T
F
P
I
L
R
E
R
---------
V
D
G
I
L
T
V
S
E
E
A
L
L
E
A
E
R
L
L
F
T
R
T
K
Q
V
V
E
P
T
G
A
L
P
L
A
A
-----
V
-
L
E
H
G
-----
A
-----
R
------------
L
P
--
Q
T
L
A
L
L
L
S
-
G
G
-
N
R
D
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
45.62
33%
-19
- C2 -
-
1VE5
1
?
A:
[42-310]
------------------------------------------------------------
E
H
L
Q
K
T
G
S
F
K
A
R
G
A
L
S
K
A
L
A
L
---
E
N
P
K
---
G
L
L
A
V
S
S
G
N
H
A
Q
G
V
A
Y
A
A
Q
V
L
G
V
K
A
L
V
V
M
P
E
D
--
P
Y
K
K
A
C
A
R
A
Y
G
A
E
V
V
D
R
G
V
T
A
K
N
R
E
E
V
A
R
A
-
L
Q
E
-
E
-
T
-
G
Y
A
L
I
H
P
F
D
D
P
L
V
I
A
G
Q
G
T
A
G
L
E
L
L
A
Q
A
G
----
R
M
G
V
FPG
A
V
L
A
P
V
G
G
G
G
L
L
A
G
L
A
T
A
V
K
--
A
L
S
-
P
T
-
T
L
V
L
G
V
E
---
P
E
A
A
-
D
D
A
K
R
S
L
E
A
G
R
I
L
R
L
E
-
A
-
P
P
R
-
T
R
A
D
G
V
R
T
L
S
L
G
E
R
T
F
P
I
L
R
E
R
V
D
---------
G
I
L
T
V
S
E
E
A
L
L
E
A
E
R
L
L
F
T
R
T
K
Q
V
V
E
P
T
G
A
L
P
L
A
A
-----
V
-
L
E
H
G
-----
A
-----
R
-----
L
P
---------
Q
T
L
A
L
L
L
S
-
G
G
-
N
R
D
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
38.79
33%
-19
- C2 -
-
1VE5
1
?
D:
[42-310]
------------------------------------------------------------
E
H
L
Q
K
T
G
S
F
K
A
R
G
A
L
S
K
A
L
A
L
---
E
N
P
K
---
G
L
L
A
V
S
S
G
N
H
A
Q
G
V
A
Y
A
A
Q
V
L
G
V
K
A
L
V
V
M
P
------------------------------
V
A
R
A
-
L
Q
E
-
E
-
T
-
G
Y
A
L
I
H
P
F
D
D
P
L
V
I
A
G
Q
G
T
A
G
L
E
L
L
A
Q
A
G
----
R
M
G
V
FPG
A
V
L
A
P
V
G
G
G
G
L
L
A
G
L
A
T
A
V
K
--
A
L
S
-
P
T
-
T
L
V
L
G
V
E
---
P
E
A
A
-
D
D
A
K
R
S
L
E
A
G
R
I
L
R
L
E
-
A
-
P
P
R
-
T
R
A
D
G
V
R
T
L
S
L
G
E
R
T
F
P
I
L
R
E
R
V
D
---------
G
I
L
T
V
S
E
E
A
L
L
E
A
E
R
L
L
F
T
R
T
K
Q
V
V
E
P
T
G
A
L
P
L
A
A
-----
V
-
L
E
H
G
-----
A
-----
R
-----
L
P
---------
Q
T
L
A
L
L
L
S
-
G
G
-
N
R
D
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
37.81
33%
-14
- C2 -
-
1VE5
1
?
C:
[42-310]
------------------------------------------------------------
E
H
L
Q
K
T
G
S
F
K
A
R
G
A
L
S
K
A
L
A
L
---
E
N
P
K
---
G
L
L
A
V
S
S
G
N
H
A
Q
G
V
A
Y
A
A
Q
V
L
G
V
K
A
L
V
------------------------------------
A
-
L
Q
E
-
E
-
T
-
G
Y
A
L
I
H
P
F
D
D
P
L
V
I
A
G
Q
G
T
A
G
L
E
L
L
A
Q
A
G
----
R
M
G
V
FPG
A
V
L
A
P
V
G
G
G
G
L
L
A
G
L
A
T
A
V
K
--
A
L
S
-
P
T
-
T
L
V
L
G
V
E
---
P
E
A
A
-
D
D
A
K
R
S
L
E
A
G
R
I
L
R
L
E
-
A
-
P
P
R
-
T
R
A
D
G
V
R
T
L
S
L
G
E
R
T
F
P
I
L
R
E
R
V
D
---------
G
I
L
T
V
S
E
E
A
L
L
E
A
E
R
L
L
F
T
R
T
K
Q
V
V
E
P
T
G
A
L
P
L
A
A
-----
V
-
L
E
H
G
-----
A
-----
R
-----
L
P
---------
Q
T
L
A
L
L
L
S
-
G
G
-
N
R
D
F
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------