@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQP4: (2017-11-28 )
MNNMHSQTTIAAIATPPGRGGVGVIRLSGPKAYNIAQKLTQKNLPEARMAGFRKFYDTDGSIMDEGIVLCFPNPHSFTGEDVVELQGHGGPVIQNALLGRLFELGANAAKAGEFSMRAFENGKMDLVQAEAIADLIDATSQAAARSAVRSLQGAFSTKINTVLEKLIHLRLHVEAAIDFPEEEIDFLADGKILALLEDVQQSVHAVQTSARQGQLLREGLQVVIAGKPNAGKSSLLNALAGVERAIVTDIAGTTRDVLHEKISLNGLPITLTDTAGLRETGDVVEKEGIRRAIKEIEQADLLLLVYDLNQGDDPLKLAQEYFAEHIEPRRLMLIGNKCDLTGQSAEISDYQGFRHITVSAKQEMGVQGLVDAITAHAGFHPEEDTFIARTRHLDAMTRTQLYLAEAREQLVVFNAGELVAESLRLAQNALGEITGDFSADDLLGKIFGSFCIGK
Atome Classification :
(23 SA)
.........10.....--.--..20........30.......---.-40---.-----.-.--...--.--.50........-60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180-.-......190.......200.......210.......220.......230.......240.......250.......260.......270......-.-280.---......290.......300......--.310.--.......320.......330.......340----.--.----....----.----350.-..-..----..360....----...370.--.....--.---380--..--.....-.390.......400.......410.......420.......430.......440.......450..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNNMHSQ
T
T
I
A
A
I
ATP--P--GRG
G
V
G
V
I
R
LSGPK
A
Y
N
I
A
Q
K
---
L
-
T
Q---K-----N-L--
P
E
A
--
R
--
M
A
G
F
R
K
F
YDTD-GSIMDE
G
I
V
L
C
FPNPHSFTGE
D
V
V
E
LQGHG
G
P
V
I
Q
N
A
L
L
G
R
L
F
E
LGANAAKAGE
F
S
M
R
A
FENGK
M
D
L
V
Q
A
E
A
I
A
D
L
I
D
A
T
S
Q
A
A
A
R
S
A
V
R
S
L
Q
G
A
F
S
T
K
I
N
T
V
L
E
K
L
I
H
L
R
L
H
V
E
A
AIDF
P
E
E
-
E
-
I
D
F
LADG
K
I
L
A
L
L
E
D
V
Q
Q
S
V
H
A
V
Q
T
S
ARQ
G
Q
L
L
R
EG
L
Q
V
V
I
AGKPNA
G
K
S
S
L
L
N
A
L
A
G
V
E
R
A
I
V
T
DIAG
T
T
R
D
V
L
H
E
K
ISLNG
L
P
I
T
LTDTAGLR-E-TG
D
V
---
V
E
K
E
G
I
R
R
A
I
K
E
I
E
QA
D
L
L
L
L
V
Y
DL--NQ-GD--
D
P
L
K
L
A
Q
E
Y
F
A
E
HIEP
R
R
L
M
L
IGNKCDLTG----Q--S----AEIS----D----YQG
F
-
R
H
-
I
T
----V
S
A
K
Q
EMG
V
----
Q
G
L
V
D
A
I
--
T
A
HAG--F---H-P--EE--D
T
F
I
A
-
R
T
R
H
L
D
A
M
T
R
T
Q
L
Y
L
A
E
ARE
Q
L
V
V
FN
A
G
E
L
V
A
E
S
L
R
L
A
Q
N
A
L
G
E
ITGDF
S
A
D
D
L
L
G
K
I
F
G
S
FCIGK
110
Fugue
77.25
35%
-43
- C2 -
-
1XZP
-
MNME_THEMA
A:
[27-482]
S
S
V
D
K
L
M
D
T
I
V
A
V
A
T
P
--
P
--
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
K
I
V
Q
K
---
H
-
L
R
---
T
-----
R
-
S
--
K
I
V
--
P
--
R
K
A
I
H
G
W
I
H
E
N
-
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
-
I
-
E
--
T
N
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S
E
-
T
N
D
L
---
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
------
A
S
--
S
P
L
D
E
E
D
R
K
I
L
E
R
I
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
E
KIN
E
E
--
E
----
I
K
N
K
----
L
----
G
T
D
R
-
H
M
-
V
K
----
I
S
A
L
K
G
E
G
L
----
E
K
L
E
E
S
I
--
Y
R
E
T
Q
--
E
---
I
-
F
--
E
R
G
S
D
S
L
I
T
-
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
21
PsiBlast_CBE
73.87
37%
-20
- C2 -
-
3GEI
1
MNME_CHLTE
B:
[18-476]
---------
I
A
A
I
A
T
P
--
V
--
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
---
V
-
F
R
---
K
V
H
GSG
K
-
L
--
A
E
A
AG
Y
--
T
A
H
F
G
R
L
Y
D
G
E
--
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
-
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
GT
E
R
-
L
D
--
D
E
L
T
E
I
R
E
L
K
A
A
H
-
P
A
A
K
F
L
T
V
A
N
K
L
D
R
A
A
----
N
--
A
DALI
R
A
I
A
----
D
----
G
T
G
T
-
E
V
-
I
G
----
I
S
A
L
N
G
D
G
I
DTLK
Q
H
M
G
D
L
V
--
K
-------------------
S
V
L
V
T
-
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
122
HHSearch
72.63
37%
5
- C2 -
-
3GEH
2
MNME_NOSS1
A:
[3-462]
--
H
M
A
I
T
G
T
I
A
A
I
A
T
A
--
I
V
P
Q
Q
G
S
V
G
I
V
R
V
S
G
S
Q
A
I
A
I
A
Q
T
---
L
F
D
A
---
P
G----
K
Q
V
--
W
E
S
--
H
--
R
I
L
Y
G
Y
I
R
H
P
Q
T
R
Q
I
V
D
E
A
L
L
L
L
M
K
A
P
R
S
Y
T
R
E
D
V
V
E
F
H
C
H
G
G
I
I
A
V
Q
Q
V
L
Q
L
C
L
E
S
G
A
R
L
A
Q
P
G
E
F
T
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
G
A
R
S
P
Q
A
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
E
E
D
-
L
P
P
L
D
--
D
E
A
I
I
S
D
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
K
G
E
L
L
R
T
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
V
V
E
S
Q
L
V
V
G
G
I
P
V
Q
V
L
D
-------------------------
Q
A
A
N
T
A
D
L
V
L
L
T
I
D
A
--
A
T
G
W
T
--
T
G
D
Q
E
I
Y
E
Q
V
----
K
H
R
P
L
I
L
V
M
N
K
I
D
L
V
E
----
K
--
Q
----
L
I
T
S
----
L
EYP-
E
N
I
T
-
Q
I
-
V
H
----
T
A
A
A
Q
K
Q
G
I
----
D
S
L
E
T
A
I
--
L
E
I
V
Q
--
T
GKV
Q
-
A
--
A
D
--
M
D
L
A
I
-
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
E
Q
V
Q
A
T
I
T
Q
Q
L
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
123
HHSearch
72.46
36%
19
- C2 -
-
1XZP
-
MNME_THEMA
A:
[28-482]
-
S
V
D
K
L
M
D
T
I
V
A
V
A
T
P
--
P
--
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
K
I
V
Q
K
---
H
L
R
T
---
R
-----
S
-
K
--
I
V
P
--
R
--
K
A
I
H
G
W
I
H
E
N
--
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
-
I
E
T
N
T
---
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
I
L
F
R
I
V
D
T
A
G
V
R
-
S
E
T
N
D
L
---
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
A
--
S
S
P
L
D
--
E
E
D
R
K
I
L
E
R
I
----
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
E
----
K
--
I
----
N
E
E
E
----
I
K
N
K
L
G
T
D
R
-
H
M
-
V
K
----
I
S
A
L
K
G
E
G
L
----
E
K
L
E
E
S
I
--
Y
R
E
T
Q
--
E
I
F
-
E
-
R
--
G
S
--
D
S
L
I
T
-
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
5
PsiBlast_PDB
71.92
37%
-1
- C2 -
-
3GEH
2
MNME_NOSS1
A:
[2-462]
-
S
H
M
A
I
T
G
T
I
A
A
I
A
T
A
I
V
P
--
Q
Q
G
S
V
G
I
V
R
V
S
G
S
Q
A
I
A
I
A
Q
T
---
L
-
F
D
A
P
G
K
-----
Q
-
V
--
W
E
S
--
H
R
I
L
Y
G
Y
I
R
H
P
Q
T
R
--
Q
I
V
D
E
A
L
L
L
L
M
K
A
P
R
S
Y
T
R
E
D
V
V
E
F
H
C
H
G
G
I
I
A
V
Q
Q
V
L
Q
L
C
L
E
S
G
A
R
L
A
Q
P
G
E
F
T
L
R
A
F
L
N
G
R
L
D
L
T
Q
A
E
S
I
A
D
L
V
G
A
R
S
P
Q
A
A
Q
T
A
L
A
G
L
Q
G
K
L
A
H
P
I
R
Q
L
R
A
N
C
L
D
I
L
A
E
I
E
A
R
I
D
F
-
E
E
-
D
-
L
P
P
L
D
D
E
A
I
I
S
D
I
E
N
I
A
A
E
I
S
Q
L
L
A
T
K
D
K
G
E
L
L
R
T
G
L
K
V
A
I
V
G
R
P
N
V
G
K
S
S
L
L
N
A
W
S
Q
S
D
R
A
I
V
T
D
L
P
G
T
T
R
D
V
V
E
S
Q
L
V
V
G
G
I
P
V
Q
V
L
D
-------------------------
Q
A
A
N
T
A
D
L
V
L
L
T
I
D
A
--
A
T
-
G
-----
W
T
T
G
D
Q
E
I
Y
E
Q
V
K
H
R
P
L
I
L
V
M
N
K
I
D
L
V
-----
E
--
K
----
Q
L
I
T
----
S
----
L
E
Y
P
-
E
N
-
I
T
Q
I
V
H
T
A
A
A
Q
K
Q
G
I
----
D
S
L
E
T
A
I
L
E
I
V
Q
T
G
--
K
---
V
-
Q
--
A
A
--
D
M
D
L
A
I
N
Q
R
Q
A
A
A
L
T
Q
A
K
M
S
L
E
Q
V
Q
A
T
I
T
Q
Q
L
P
L
D
F
W
T
I
D
L
R
G
A
I
Q
A
L
G
E
I
T
G
E
E
V
T
E
S
V
L
D
R
I
F
S
R
F
C
I
G
K
4
PsiBlast_PDB
71.22
37%
-18
- C2 -
-
3GEI
1
MNME_CHLTE
A:
[18-476]
---------
I
A
A
I
A
T
P
--
V
--
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
---
V
-
F
R
---
K
V
H
GSG
K
-
L
--
A
E
A
AG
Y
--
T
A
H
F
G
R
L
Y
D
G
E
--
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
-
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
GT
E
R
-
L
D
--
D
E
L
T
E
I
R
E
L
K
A
A
H
-
P
A
A
K
F
L
T
V
A
N
K
L
D
R
A
A
----
N
--
A
D
A
L
I
R
A
I
A
----
D
----
G
T
G
T
-
E
V
-
I
G
----
I
S
A
L
N
G
D
G
I
D
T
L
K
Q
H
M
G
D
L
V
--
K
N
L
-------------
E
A
--
S
V
L
V
T
-
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
3
PsiBlast_PDB
71.15
37%
-14
- C2 -
-
3GEE
2
MNME_CHLTE
A:
[18-476]
---------
I
A
A
I
A
T
P
--
V
--
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
---
V
-
F
R
---
K
VHGSG
K
-
L
--
A
E
A
AG
Y
--
T
A
H
F
G
R
L
Y
D
G
E
--
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
-
V
E
F
Q
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
GT
E
R
-
L
D
--
D
E
L
T
E
I
R
E
L
K
A
A
H
-
P
A
A
K
F
L
T
V
A
N
K
L
D
R
A
A
----
N
--
A
D
A
L
I
R
A
I
A
----
D
----
G
T
G
T
-
E
V
-
I
G
----
I
S
A
L
N
G
D
G
I
D
T
L
K
Q
H
M
G
D
L
V
--
K
N
L
D
K
--
L
---
H
----
E
A
--
S
V
L
V
T
-
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
1
PsiBlast_PDB
70.23
37%
40
- C2 -
-
1XZP
-
MNME_THEMA
A:
[35-482]
--------
T
I
V
A
V
A
T
P
--
P
--
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
K
I
V
Q
K
H
L
R
T
-
R
S
---
K
-----
I
-
V
--
P
R
K
--
A
--
I
H
G
W
---
I
H
E
N
-
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
E
-
T
N
---
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S
E
-
T
N
D
L
---
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
------
A
S
--
S
P
L
D
E
E
D
R
K
I
L
E
R
I
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
E
----
K
IN
E
----
E
E
I
K
----
N
----
K
L
G
T
D
R
H
M
V
K
----
I
S
A
L
K
G
E
G
L
----
E
K
L
E
E
S
I
--
Y
R
E
T
Q
E
I
F
---
E
-
R
--
G
S
--
D
S
L
I
T
-
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
2
PsiBlast_PDB
69.13
37%
40
- C2 -
-
1XZQ
2
?
A:
[35-482]
--------
T
I
V
A
V
A
T
P
--
P
--
G
K
G
A
I
A
I
L
R
L
S
G
P
D
S
W
K
I
V
Q
K
HLR
T
-
R
S
---
K
-----
I
-
V
--
P
R
K
--
A
--
I
H
G
W
---
I
H
E
N
-
G
E
D
V
D
E
V
V
V
V
F
Y
K
S
P
K
S
Y
T
G
E
D
M
V
E
V
M
C
H
G
G
P
L
V
V
K
K
L
L
D
L
F
L
K
S
G
A
R
M
A
E
P
G
E
F
T
K
R
A
F
L
N
G
K
M
D
L
T
S
A
E
A
V
R
D
L
I
E
A
K
S
E
T
S
L
K
L
S
L
R
N
L
K
G
G
L
R
D
F
V
D
S
L
R
R
E
L
I
E
V
L
A
E
I
R
V
E
L
D
Y
P
D
E
I
E
-
T
N
---
T
G
E
V
V
T
R
L
E
R
I
K
E
K
L
T
E
E
L
K
K
A
D
A
G
I
L
L
N
R
G
L
R
M
V
I
V
G
K
P
N
V
G
K
S
T
L
L
N
R
L
L
N
E
D
R
A
I
V
T
D
I
P
G
T
T
R
D
V
I
S
E
E
I
V
I
R
G
I
L
F
R
I
V
D
T
A
G
V
R
S
E
-
T
N
D
L
---
V
E
R
L
G
I
E
R
T
L
Q
E
I
E
K
A
D
I
V
L
F
V
L
D
------
A
S
--
S
P
L
D
E
E
D
R
K
I
L
E
R
I
K
N
K
R
Y
L
V
V
I
N
K
V
D
V
V
E
----
K
IN
E
----
E
E
I
K
----
N
----
K
L
G
T
D
R
H
M
V
K
----
I
S
A
L
K
G
E
G
L
----
E
K
L
E
E
S
I
--
Y
R
E
T
Q
E
I
F
---
E
-
R
--
G
S
--
D
S
L
I
T
-
N
L
R
Q
K
Q
L
L
E
N
V
K
G
H
L
E
D
A
I
K
S
L
K
E
G
M
P
V
D
M
A
S
I
D
L
E
R
A
L
N
L
L
D
E
V
T
G
R
S
F
R
E
D
L
L
D
T
I
F
S
N
F
C
V
G
K
120
HHSearch
68.89
36%
8
- C2 -
-
3GEE
2
MNME_CHLTE
A:
[12-476]
---
P
V
P
G
H
P
I
A
A
I
A
T
P
--
V
--
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
---
V
F
R
K
---
V
HGSG-
K
-
L
AE
A
A
G
--
Y
--
T
A
H
F
G
R
L
Y
D
G
--
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
-
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
--
G
T
E
R
L
D-
D
E
L
T
-
E
I
R
E
L
K
A
A
H
P
A
A
K
F
L
T
V
A
N
K
L
D
R
A
A
----
N
--
A
----
D
A
L
I
R
A
I
A
D
----
G
T
G
T
-
E
V
-
I
G
----
I
S
A
L
N
G
D
G
I
----
D
T
L
K
Q
H
M
--
G
D
L
V
K
--
N
---
L
D
K
L
H
E
A
--
S
V
L
V
T
-
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
121
HHSearch
68.87
36%
11
- C2 -
-
3GEI
1
MNME_CHLTE
A:
[10-476]
-
H
L
P
V
P
G
H
P
I
A
A
I
A
T
P
--
V
--
G
V
G
A
L
A
I
V
R
I
S
G
A
G
V
L
D
L
A
D
R
---
V
F
R
K
---
V
H
GSG-
K
-
L
AE
A
A
G
--
Y
--
T
A
H
F
G
R
L
Y
D
G
--
E
E
M
V
D
E
V
I
A
L
V
F
R
A
P
R
S
F
T
A
E
Q
M
V
E
F
T
C
H
G
G
P
V
V
V
G
R
V
L
R
L
M
L
D
N
G
C
R
L
A
E
P
G
E
F
T
R
R
A
F
L
N
G
R
I
D
L
L
Q
A
E
A
I
G
E
M
I
H
A
R
T
E
S
A
Y
R
T
A
V
S
Q
M
K
G
D
L
S
V
R
L
G
G
L
R
E
Q
L
I
R
S
C
A
L
I
E
L
E
L
D
F
S
E
E
-
D
V
E
F
Q
-
S
R
D
E
L
T
M
Q
I
E
T
L
R
S
E
V
N
R
L
I
D
S
Y
Q
H
G
R
I
V
S
E
G
V
S
T
V
I
A
G
K
P
N
A
G
K
S
T
L
L
N
T
L
L
------------------
E
E
C
F
I
H
D
K
T
M
F
R
L
T
D
-------------------------
M
K
M
A
E
A
D
L
I
L
Y
L
L
D
L
--
G
T
E
R
L
D-
D
E
L
T
-
E
I
R
E
L
K
A
A
H
P
A
A
K
F
L
T
V
A
N
K
L
D
R
A
A
----
N
--
A
----
D
A
L
I
R
A
I
A
D
----
G
T
G
T
-
E
V
-
I
G
----
I
S
A
L
N
G
D
G
I
----
D
T
L
K
Q
H
M
--
G
D
L
V
K
--
N
---
L
----
E
A
--
S
V
L
V
T
-
S
L
R
H
Y
E
A
L
R
N
A
S
D
A
L
Q
N
A
L
E
L
I
A
H
E
S
E
T
E
L
I
A
F
E
L
R
A
A
L
D
Y
V
G
Q
I
T
G
K
V
V
N
E
E
V
L
N
T
I
F
D
K
F
C
I
G
K
8
PsiBlast_PDB
55.46
49%
-34
- C2 -
-
2GJA
1
MNME_ECOLI
A:
[4-166]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
G
--
F
------------------------------------------------------------------------------------
22
PsiBlast_CBE
54.04
49%
-32
- C2 -
-
2GJA
1
B:
[4-163]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
-----------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.66
49%
-29
- C2 -
-
2GJ8
2
MNME_ECOLI
A:
[4-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
----------------------------------------------------------------------------------------
23
PsiBlast_CBE
53.33
49%
-30
- C2 -
-
2GJ9
1
D:
[5-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
----------------------------------------------------------------------------------------
7
PsiBlast_PDB
52.79
49%
-28
- C2 -
-
2GJ9
1
MNME_ECOLI
A:
[4-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
----------------------------------------------------------------------------------------
25
PsiBlast_CBE
52.58
49%
-34
- C2 -
-
2GJ9
1
MNME_ECOLI
B:
[5-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
----------------------------------------------------------------------------------------
24
PsiBlast_CBE
51.44
49%
-24
- C2 -
-
2GJ9
1
MNME_ECOLI
C:
[4-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
-
A
S
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
-
T
D
AV
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
----------------------------------------------------------------------------------------
130
HHSearch
49.21
49%
-9
- C2 -
-
2GJ8
1
MNME_ECOLI
C:
[4-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
M
K
V
V
I
A
G
R
P
N
A
G
K
S
S
L
L
N
A
L
A
G
R
E
A
A
I
V
T
D
I
A
G
T
T
R
D
V
L
R
E
H
I
H
I
D
G
M
P
L
H
I
I
D
T
A
G
L
R
-
E
A
S
-
D
E
---
V
E
R
I
G
I
E
R
A
W
Q
E
I
E
Q
A
D
R
V
L
F
M
V
D
G
--
T
T
T
D
A
V-
D
P
A
E
I
W
P
E
F
I
A
R
L
P
A
K
L
P
I
T
V
V
R
N
K
A
D
I
T
G
----
E
--
T
----
L
G
M
S
----
E
----
V
N
G
H
-
A
L
-
I
R
----
L
S
A
R
T
G
E
G
V
----
D
V
L
R
N
H
L
--
K
Q
S
M
----------------------------------------------------------------------------------------
13
PsiBlast_PDB
44.45
41%
-88
- C2 -
-
4DCU
1
DER_BACSU
A:
[194-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
-
K
-
K
G
K
V
YET
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
--
E
E
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
43.93
41%
-93
- C2 -
-
4DCS
1
DER_BACSU
A:
[194-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
-
K
-
K
G
K
V
YET
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
--
E
E
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
43.16
41%
-98
- C2 -
-
4DCV
1
DER_BACSU
A:
[194-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
I
Q
F
C
L
I
G
R
P
N
V
G
K
S
S
L
V
N
A
M
L
G
E
E
R
V
I
V
S
N
------
D
A
V
D
T
S
F
T
Y
N
Q
Q
E
F
V
I
V
D
T
A
G
M
R
-
K
-
K
G
K
V
YET
T
E
K
Y
S
V
L
R
A
L
K
A
I
D
R
S
E
V
V
A
V
V
L
D
G
--
E
E
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
37.40
41%
-131
- C2 -
-
1MKY
1
DER_THEMA
A:
[179-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
I
K
V
A
I
V
G
R
P
N
V
G
K
S
T
L
F
N
A
I
L
N
K
E
R
A
L
V
S
P
I
P
------
V
D
D
E
V
F
I
D
G
R
K
Y
V
F
V
D
T
A
G
L
------------
E
K
Y
S
N
Y
R
V
V
D
S
I
E
K
A
D
V
V
V
I
V
L
D
A
--
T
Q
-
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------