@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQP9: (2017-11-28 )
MTSVHQLQGVGSASAALLEKLNIFTTDDLLFHLPRDYEDRSTIIPMNQLMVGRTYLLEGEVKSVDFPPGKRKSMAALIQDEFGKVTLRFYHIYKNLTDKIKPGNRLRIFGEVRVGARGLELYHPEIQLINEHTTLPKTQLTAIYPSTDGLTQAKLREYVKQALKHHSDALPELLPKQYTNGYALKEALHYIHEPPIDANMIQLAQDSHPAQQRLIFEELVAHQISLLTRRAYIRQIASPAFPSSKVLAKKLLEALPFQMTNAQKRVSKEILNDLKQHQPMLRLVQGDVGAGKTLVAAVAACHALEADWQVALMAPTEILAEQHYLNFKRWFEPLGITVAWLSGKQKGKARAHAERQIKEGHAELIVGTHALFQDNVEFAKLGLVIIDEQHRFGVDQRLALRNKGAEQLTPHQLVMTATPIPRTLAMSAYGDLDTSIIDELPPGRTPIQTVTIPLDRREEVLQRIASNCREGKQAYWVCTLVEQSETLDAQAAEATYQEMKERFPELNIGLVHGKMKADEKQAVMQAFKNNELQLLIATTVIEVGVDVPNASIMVIENAERLGLSQLHQLRGRVGRGAKASFCVLLYKPPLSQNGQERLSILRESNDGFVIAEKDLELRGPGELLGTKQTGDMGFRVARLERDDHLLSQAHYVAQQVLKDYPEQADALLKRWLPEAPRYAYV
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40........50-.........60.......-------.70..-......80........90-........100-........110..--.....120.......130......-----.140.......--150.......160....----...170....---...180-..---.....190-------....----....200.......210.......220....-..-.--------230.......240.......250....-----.-..260.......270.......280.......290.......300...---.------------..--.--310.......320.......330.--------------.------.....340..--.....350.....--..360...----....370-------..-----.----------....380.----......390---..---.---...-------.----.-400-----...----.-----.----..-----..410.......420......--.--430-------------------.....--------...440....-----...---450..-------.-------.-----.--..460.....--.-.470....-----------..----------------.480.......----------------------------------------------------490..----------------.....-500.....--.-----------..510-.----......520.......530.---------------......540.......550...------------...------.560.------------......570....--...580......-------.--590.........600...---.---...610-.......-------620.......630---..---.-....640.......650...--....660.....-------..670.......680---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTS
V
H
Q
L
QGV
G
S
A
S
A
A
L
L
E
K
LNIFTT
D
D
L
L
F
HLPRDYEDRS
T
I
I
P
M
N
Q
L
M
--VG
R
T
Y
L
LEGEVKSVDFPP-------G
K
R
K
S
-
M
A
A
L
I
Q
DEFG
K
V
T
L
R
F
Y
H
-
I
Y
K
N
L
T
DKIK--PG
N
R
L
R
I
F
G
E
V
R
V--GAR
G
L
E
LYHP
E
I
Q
L
INEHTTLPK
T
-----
Q
L
T
A
I
YPSTDG--L
T
Q
A
K
L
R
E
Y
V
K
Q
A
L
K
HH----S
D
A
L
P
E
L
L
P
K
---QYTN
G
Y
-
A
L
---
K
E
A
L
H
Y
I
--------HEPP----I
D
A
N
M
I
Q
L
AQDSH
P
A
Q
Q
R
L
I
F
E
E
L
V
A
H
Q
I
S
L
-
L
T
-
R
--------
R
A
Y
I
R
Q
IASPAFP
S
S
K
V
L
A
K
K
L
L
E
ALP-----F-QM
T
N
A
Q
K
R
V
S
K
E
I
L
N
D
L
K
Q
H
Q
P
M
L
R
L
V
QGDVGA
G
K
T
L
V
A
A
V
A
A
C
H
ALE---A------------D
W
--
Q
--
V
A
L
MA
P
T
E
I
L
A
E
Q
H
Y
L
N
F
K
R
W
F
EP--------------L------
G
I
T
V
A
W
LSGK--QKGK
A
R
A
H
A
E
R
Q
I
--
K
EGHA
E
L
I
----
V
G
T
H
A
L
F
-------QD-----N----------V
E
F
A
K
L
G
L
----
V
I
I
DE
Q
H
R----FG---V---
D
Q
R
-------
L
----
A
-
L
-------RNK----G-----A----EQ-----LTP
H
Q
L
V
M
TATPIP
R
T
L
A
M
S
A--Y--GD--------------------L
D
T
S
I
--------
I
DELPPGRT
P
-----
I
Q
T
---
V
T
IP
L
-------
D
-------
R
-----
R
--
E
E
V
L
Q
R
I
A
S
N
--
C
-REG
K
Q
A
Y
W
-----------
V
C
----------------
T
LVEQSETL
D
A
----------------------------------------------------
Q
A
A
E
A
----------------
T
Y
Q
E
M
-
K
E
-RFPEL--
N
-----------
I
G
L
V
H-G----KMK
A
D
E
K
Q
A
V
M
Q
A
FKNN
E
L
Q
---------------
L
L
I
A
T
T
V
I
E
VGVDVPN
A
S
I
M
V
I
------------E
N
A
------
E
RL
G
L
------------
S
Q
L
H
Q
L
R
G
RVGRG--AK
A
S
F
C
V
L
L
YKP-------P--L--SQN
G
Q
E
R
L
S
I
L
RESN---D---
G
F
V
I
A
E-K
D
L
ELRG-------P
G
E
LLGTKQTGDM---
G
F
---
R
-
V
A
RLERD
D
H
L
L
S
Q
A
H
Y
V
A
Q
Q
--
V
L
K
DY
P
E
Q
A
D
A
L
-------
L
K
R
WLPEAPRYAYV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
74.13
39%
13
- C2 -
-
1GM5
4
?
A:
[115-755]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
I
Q
Y
A
K
G
V
G
P
N
R
K
K
K
L
K
K
L
G
I
E
T
L
R
D
L
L
E
F
F
P
R
D
Y
E
D
R
R
K
I
F
K
L
N
D
L
L
--
P
G
E
K
V
T
T
Q
G
K
I
V
S
V
E
T
K
K
-------
F
Q
N
M
N
I
L
T
A
V
L
S
D
G
L
V
H
V
P
L
K
W
F
N
Q
D
Y
L
Q
T
Y
L
K
Q
L
--
T
G
K
E
V
F
V
T
G
T
V
K
S
--
N
A
-----
Y
T
G
Q
Y
E
I
H
N
A
E
V
T
-
P
K
E
GEYVR
R
I
L
P
I
Y
R
L
T
S
G
--
I
S
Q
K
Q
M
R
K
I
F
E
E
N
I
P
S
L
----
C
C
S
L
K
E
T
L
P
E
---
R
I
L
E
K
R
-
K
L
L
G
V
K
D
A
Y
Y
G
M
--------
H
F
P
K
----
T
F
Y
H
L
-------
E
K
A
R
E
R
L
A
Y
E
E
L
F
V
L
Q
L
A
F
Q
K
I
-
R
--------
K
E
R
E
K
H
G
G
I
P
K
K
I
E
G
K
-
L
A
E
E
F
I
K
S
L
P
-----
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
E
K
P
M
N
R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---
A
------------
G
F
--
Q
--
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
--------------
F
------
N
I
H
V
A
L
L
I
G
A
--
T
T
P
S
E
K
E
K
I
K
S
G
L
--
R
N
G
Q
I
D
V
V
----
I
G
T
H
A
L
I
-------
Q
E
-----
D
----------
V
H
F
K
N
L
G
L
----
V
I
I
D
E
Q
H
R
----
F
------------------
E
----
A
-
L
-------
M
N
K
----
G
-----
K
----
M
V
-----
D
T
---
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
--
Y
--
G
D
--------------------
L
D
V
T
V
--------
I
D
E
M
P
P
G
R
K
E
-----
V
Q
T
---
M
L
V
P
M
-------
D
-------
R
-----
V
--
N
E
V
Y
E
F
V
R
Q
E
--
V
-
M
R
G
G
Q
A
F
I
-----------
V
Y
----------------
P
L
I
------------------------------------------------------------
K
S
A
V
E
----------------
M
Y
E
Y
L
S
K
E
-
V
F
-----
K
-----------
L
G
L
M
H
-
G
----
R
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
---------------
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
------------
E
N
P
------
E
R
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
G
--
G
Q
E
A
Y
C
F
L
V
V
-
G
-------
D
--
V
--
G
E
E
A
M
E
R
L
R
F
F
T
L
N
T
---
D
---
G
F
K
I
A
E
-
Y
D
L
K
T
R
G
-------
P
G
E
----
K
Q
H
G
L
S
---
G
F
---
K
-
V
A
D
L
Y
R
D
L
K
L
L
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
73.66
39%
16
- C2 -
-
1GM5
4
?
A:
[115-755]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
I
Q
Y
A
K
G
V
G
P
N
R
K
K
K
L
K
K
L
G
I
E
T
L
R
D
L
L
E
F
F
P
R
D
Y
E
D
R
R
K
I
F
K
L
N
D
L
L
--
P
G
E
K
V
T
T
Q
G
K
I
V
S
V
E
T
K
K
F
------
Q
N
M
N
I
-
L
T
A
V
L
S
D
G
L
V
H
V
P
L
K
W
F
N
-
Q
-
D
Y
L
Q
T
Y
L
K
Q
L
T
G
K
E
V
F
V
T
G
T
V
K
S
NA
Y
T
G
Q
Y
E
I
H
N
A
E
V
T
P
K
E
---
G
E
Y
V
R
-----
R
I
L
P
I
Y
R
L
T
S
G
--
I
S
Q
K
Q
M
R
K
I
F
E
E
N
I
P
S
L
----
C
C
S
L
K
E
T
L
P
E
R
I
L
E
K
R
K
L
L
-
G
V
---
K
D
A
Y
Y
G
M
--------
H
F
P
K
----
T
F
Y
H
L
E
-------
K
A
R
E
R
L
A
Y
E
E
L
F
V
L
Q
L
A
F
-
Q
K
-
I
--------
R
K
E
R
E
K
H
G
G
I
P
K
K
I
E
G
K
L
A
E
E
F
I
K
S
L
P
-----
F
-
K
L
T
N
A
Q
K
R
A
H
Q
E
I
R
N
D
M
I
S
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R
L
L
Q
G
D
V
G
S
G
K
T
V
V
A
Q
L
A
I
L
D
N
Y
E
---
A
------------
G
F
--
Q
--
T
A
F
M
V
P
T
S
I
L
A
I
Q
H
Y
R
R
T
V
E
S
F
S
K
--------------
F
------
N
I
H
V
A
L
L
I
G
A
--
T
T
P
S
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K
E
K
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K
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--
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----
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G
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H
A
L
I
-------
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-----
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----------
V
H
F
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N
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L
----
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I
I
D
E
Q
H
R
----
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------------------
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----
A
-
L
-------
M
N
K
----
G
-----------------
K
M
V
D
T
L
V
M
S
A
T
P
I
P
R
S
M
A
L
A
F
--
Y
--
G
D
--------------------
L
D
V
T
V
--------
I
D
E
M
P
P
G
R
K
E
-----
V
Q
T
---
M
L
V
P
M
-------
D
-------
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-----
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--
N
E
V
Y
E
F
V
R
Q
E
--
V
-
M
R
G
G
Q
A
F
I
-----------
V
Y
----------------
P
L
I
------------------------------------------------------------
K
S
A
V
E
----------------
M
Y
E
Y
L
-
S
K
E
V
F
-----
K
-----------
L
G
L
M
H
-
G
----
R
L
S
Q
E
E
K
D
R
V
M
L
E
F
A
E
G
R
Y
D
---------------
I
L
V
S
T
T
V
I
E
V
G
I
D
V
P
R
A
N
V
M
V
I
------------
E
N
P
------
E
R
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
G
--
G
Q
E
A
Y
C
F
L
V
V
G
D
-------
V
-----
G
E
E
A
M
E
R
L
R
F
F
T
L
N
T
---
D
---
G
F
K
I
A
E
-
Y
D
L
K
T
R
G
-------
P
G
E
----
K
Q
H
G
L
S
---
G
F
---
K
-
V
A
D
L
Y
R
D
L
K
L
L
E
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
62.95
37%
-108
- C2 -
-
2EYQ
3
MFD_ECOLI
A:
[587-971]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
-----
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
------------
H
K
--
Q
--
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
--------------
W
------
P
V
R
I
E
M
I
S
R
F
--
R
S
A
K
E
Q
T
Q
I
L
A
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V
--
A
E
G
K
I
D
I
L
----
I
G
T
H
K
L
L
-------
Q
S
-----
D
----------
V
K
F
K
D
L
G
L
----
L
I
V
D
E
E
H
R
----
F
G
---
V
---
R
H
K
-------
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----
R
-
I
-------
K
A
M
----
R
-----------------
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
--
S
--
G
M
--------------------
R
D
L
S
I
--------
I
A
T
P
P
A
R
R
L
A
-----
V
K
T
---
F
V
R
E
Y
---------------
D
-----
S
--
M
V
V
R
E
A
I
L
R
E
--
I
-
L
R
G
G
Q
V
Y
Y
-----------
L
Y
----------------
N
--------
D
V
----------------------------------------------------
E
N
I
Q
K
----------------
A
A
E
R
L
-
A
E
-
L
V
P
E
A
--
R
-----------
I
A
I
G
H
-
G
----
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
---------------
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
------------
E
R
A
------
D
H
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
S
--
H
H
Q
A
Y
A
W
L
L
T
P
H
-------
P
--
K
AM
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
DLG
A
---
G
F
A
L
A
T
-
H
D
L
E
I
R
G
-------
A
G
E
L
L
G
E
E
Q
S
G
S
M
---
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
60.28
30%
11
- C2 -
-
2EYQ
3
MFD_ECOLI
A:
[5-1150]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEQYR
Y
T
L
P
V
K
AG
E
Q
R
L
L
GELTGA
A
C
A
T
L
V
A
E
I
A
E
R
HA
G
P
V
V
L
I
A
PD
M
Q
N
A
L
R
L
H
D
E
I
S
Q
F
T
D
Q
M
V
M
N
LADWETLPYDSFSPH
Q
D
I
I
S
S
R
L
S
T
L
Y
Q
LPTMQ
R
G
V
L
I
V
P
V
N
T
L
M
Q
R
V
C
P
H
S
F
L
H
G
H
A
L
V
M
K
KGQRLS
R
D
A
L
R
T
Q
L
D
S
A
G
Y
R
H
V
DQVMEHG
E
Y
A
T
R
GA
L
L
D
L
FPMGSE
L
P
Y
R
L
D
F
F
DDEID
S
L
R
V
F
D
VDSQRTLEEVE
A
I
N
L
L
P
AHEFPTD
K
A
A
I
E
L
F
R
S
Q
W
R
D
T
F
E
V
K
RDPEH
I
Y
Q
Q
V
S
K
GTLPAGIEYW
Q
P
L
F
F
SEPLPPLFSYFPAN
T
L
L
V
N
T
G
D
L
E
T
S
A
E
R
F
Q
A
D
T
L
A
R
F
E
N
R
GVDPM
R
P
L
L
P
PQSLWLR
V
D
E
L
F
S
E
L
K
N
W
P
R
V
Q
L
K
TEHLPTKAA
N
A
N
L
GFQKLPDLAVQAQQKAPL
D
A
L
R
K
F
L
E
T
FD
G
P
V
V
F
S
V
E
S
-
E
G
R
R
E
A
L
G
E
L
L
A
R
I
K
I
A
P
---------------
Q
R
I
M
R
L
D
E
A
S
--
D
R
G
R
Y
L
M
I
G
A
A
E
H
-
G
F
V
D
-------
T
V
R
N
L
-
A
L
I
C
E
S
D
L
L
G
E
---
R
V
A
R
-
R
R
Q
D
S
R
R
T
I
N
--
P
D
T
L
I
R
N
L
A
E
L
H
I
--
G
Q
---
P
V
V
H
L
E
-
H
G
V
G
R
Y
A
G
M
T
T
L
-----
E
A
G
G
I
-------------
T
G
E
Y
L
M
L
T
Y
A
N
D
------------
A
K
---
L
Y
V
P
V
S
-
S
L
---
H
L
I
S
R
Y
A
--------
G
G
A
E
----
E
N
A
P
L
H
K
L
G
G
D
A
W
S
R
A
R
Q
K
A
A
E
K
V
R
D
V
A
A
E
L
-
L
D
-
I
--------
Y
A
Q
R
A
A
K
E
G
F
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
-----
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
------------
H
K
--
Q
--
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
--------------
W
------
P
V
R
I
E
M
I
S
R
F
--
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
----
I
G
T
H
K
L
L
-------
Q
S
-----
D
----------
V
K
F
K
D
L
G
L
----
L
I
V
D
E
E
H
R
----
F
G
---
V
---
R
H
K
-------
E
----
R
-
I
-------
K
A
M
----
R
-----
A
----
N
--------
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
--
S
--
G
M
--------------------
R
D
L
S
I
--------
I
A
T
P
P
A
R
R
L
A
-----
V
K
T
---
F
V
R
E
Y
-------
D
-------------
S
--
M
V
V
R
E
A
I
L
R
E
--
I
-
L
R
G
G
Q
V
Y
Y
-----------
L
Y
----------------
N
--------
D
V
----------------------------------------------------
E
N
I
Q
K
----------------
A
A
E
R
L
-
A
E
-
L
V
P
E
A
--
R
-----------
I
A
I
G
H
-
G
----
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
---------------
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
------------
E
R
A
------
D
H
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
S
--
H
H
Q
A
Y
A
W
L
L
T
P
H
-------
P
--
K
AM
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
---
D
LGA
G
F
A
L
A
T
-
H
D
L
E
I
R
G
-------
A
G
E
L
L
G
E
E
Q
S
G
S
M
E
T
I
G
F
---
S
-
L
Y
M
E
L
L
E
N
A
V
D
A
L
K
A
G
R
E
P
S
--
L
E
D
L
T
S
Q
Q
T
E
V
E
-------
L
R
--
M
P
S
L
L
P
D
D
F
I
PD
V
N
T
R
L
S
F
Y
K
R
I
A
S
AKT
E
N
E
L
E
E
I
K
V
E
L
I
D
R
FGLLP
D
P
A
R
T
L
L
D
I
A
R
L
R
Q
Q
A
Q
K
L
GIR
K
L
E
G
N
EK
G
G
V
I
E
F
A
EKNHVN
P
A
W
L
I
G
L
L
Q
KQPQH
Y
R
L
D
G
PT
R
L
K
F
I
Q
DLSE
R
K
T
R
I
E
W
V
R
Q
F
M
R
E
L
E
E
N
AI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
59.02
37%
-65
- C2 -
-
2EYQ
3
MFD_ECOLI
B:
[585-970]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
-----
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
------------
H
K
--
Q
--
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
--------------
W
------
P
V
R
I
E
M
I
S
R
F
--
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
----
I
G
T
H
K
L
L
-------
Q
S
-----
D
----------
V
K
F
K
D
L
G
L
----
L
I
V
D
E
E
H
R
----
F
G
---
V
---
R
H
K
-------
E
----
R
-
I
-------
K
------------
A
----
M
R
-----
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
--
S
--
G
M
--------------------
R
D
L
S
I
--------
I
A
T
P
P
A
R
R
L
A
-----
V
K
T
---
F
V
R
E
Y
-------
D
-------
S
M
V
V
--
R
--
E
A
I
L
R
E
I
L
-------
R
G
G
Q
V
Y
Y
-----------
L
Y
----------------
N
D
V
E
N
I
Q
--------------------------------------------------------
K
A
A
E
--------------------
R
L
-
A
E
-
L
V
P
E
A
--
R
-----------
I
A
I
G
H
-
G
----
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
---------------
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
------------
E
R
A
------
D
H
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
S
--
H
H
Q
A
Y
A
W
L
L
T
P
H
-------
P
KA
M
--
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
---
D
LG
A
G
F
A
L
A
T
-
H
D
L
E
I
R
G
-------
A
G
E
L
L
G
E
E
Q
S
G
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
58.98
37%
-68
- C2 -
-
2EYQ
3
MFD_ECOLI
A:
[585-970]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
K
H
D
R
E
Q
Y
Q
L
F
C
D
S
F
P
-----
F
-
E
T
T
P
D
Q
A
Q
A
I
N
A
V
L
S
D
M
C
Q
P
L
A
M
D
R
L
V
C
G
D
V
G
F
G
K
T
E
V
A
M
R
A
A
F
L
A
V
D
---
N
------------
H
K
--
Q
--
V
A
V
L
V
P
T
T
L
L
A
Q
Q
H
Y
D
N
F
R
D
R
F
A
N
--------------
W
------
P
V
R
I
E
M
I
S
R
F
--
R
S
A
K
E
Q
T
Q
I
L
A
E
V
--
A
E
G
K
I
D
I
L
----
I
G
T
H
K
L
L
-------
Q
S
-----
D
----------
V
K
F
K
D
L
G
L
----
L
I
V
D
E
E
H
R
----
F
G
---
V
---
R
H
K
-------
E
----
R
-
I
-------
K
------------
A
----
M
R
-----
A
N
V
D
I
L
T
L
T
A
T
P
I
P
R
T
L
N
M
A
M
--
S
--
G
M
--------------------
R
D
L
S
I
--------
I
A
T
P
P
A
R
R
L
A
-----
V
K
T
---
F
V
R
E
Y
-------
D
-------
S
M
V
V
--
R
--
E
A
I
L
R
E
I
L
-------
R
G
G
Q
V
Y
Y
-----------
L
Y
----------------
N
D
V
E
N
I
Q
--------------------------------------------------------
K
A
A
E
--------------------
R
L
-
A
E
-
L
V
P
E
A
--
R
-----------
I
A
I
G
H
-
G
----
Q
M
R
E
R
E
L
E
R
V
M
N
D
F
H
H
Q
R
F
N
---------------
V
L
V
C
T
T
I
I
E
T
G
I
D
I
P
T
A
N
T
I
I
I
------------
E
R
A
------
D
H
F
G
L
------------
A
Q
L
H
Q
L
R
G
R
V
G
R
S
--
H
H
Q
A
Y
A
W
L
L
T
P
H
-------
P
KA
M
--
T
T
D
A
Q
K
R
L
E
A
I
A
S
L
E
---
D
LGA
G
F
A
L
A
T
-
H
D
L
E
I
R
G
-------
A
G
E
L
L
G
E
E
Q
S
G
S
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
51.25
21%
9
- C2 -
-
4QQX
2
?
A:
[34-964]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPLDLRFWAKERGLRG
K
T
Y
P
L
V
C
H
S
L
D
A
A
A
A
A
L
V
L
W
N
E
Y
L
S
P
G
L
R
D
T
I
A
S
S
M
E
T
D
E
E
H
A
G
H
C
I
A
F
W
A
G
L
HD
I
G
K
L
T
R
E
F
Q
Q
Q
I
A
I
D
L
S
A
YPGEELS
G
E
Q
R
S
-
H
A
A
A
T
G
K
W
L
P
F
A
L
P
S
L
G
---
Y
P
N
--------
G
G
L
V
T
G
L
V
A
Q
M
L
G
--
G
H
H
G
T
F
H
P
H
P
S
F
Q
S
R
N
P
L
A
E
F
------------------
G
--
F
S
S
P
H
W
E
K
Q
R
H
A
L
L
H
A
V
----
F
D
A
T
G
R
P
T
P
P
---
D
M
L
D
G
P
-
T
A
---
S
V
V
C
G
L
V
I
L
A
D
W
L
V
S
Q
E
D
F
----
L
L
E
R
L
T
S
L
P
A
D
G
S
A
S
A
L
R
A
H
F
E
T
S
L
R
R
I
P
S
L
-
L
D
-
A
A
GL
R
P
I
T
V
P
P
A
T
F
T
E
S
F
P
H
L
S
K
P
N
G
L
Q
A
S
L
A
K
H
L
P
-----
C
-
L
C
T
G
-----------------
P
G
L
V
L
I
T
A
P
M
G
E
G
K
T
E
A
A
Y
H
V
A
D
L
L
G
K
---
A
------------
T
G
RP
G
--
R
F
L
A
L
P
T
M
A
T
A
D
Q
M
H
T
R
L
K
E
Y
A
R
Y
R
VENTDLPRSSTL
A
L
------
L
H
S
M
A
W
L
N
P
D
YA
P
A
H
R
D
P
F
A
A
T
D
W
L
--
M
G
R
K
R
G
L
L
AP
W
A
V
G
T
I
D
Q
A
L
M
A
V
LR-
A
K
-----
H
----------
N
A
L
R
L
F
G
L
A
GKV
V
V
V
D
E
A
H
A
VD
P
Y
M
Q
---
V
---
L
L
E
-------
Q
----
L
-
L
-------
R
W
L
----
G
-----
T
----
L
D
V
P
V
V
L
L
S
A
T
L
H
H
S
I
A
N
S
L
V
K
A
Y
L
E
G
A
--
R
--
G
R
R
W
N
RSEPQPVSEVSYP
G
W
L
H
V
D
A
R
I
G
K
V
T
R
S
S
D
V
D
P
L
P
I
A
T
T
P
RK
P
L
E
V
R
L
---
V
D
V
P
V
K
EGAL--
N
-------
R
-----
S
--
T
V
L
A
K
E
L
T
P
L
--
V
-
K
Q
G
G
C
A
A
I
-----------
I
C
----------------
T
--------
T
V
----------------------------------------------------
A
E
A
Q
G
----------------
V
Y
D
L
L
-
S
Q
-
W
F
A
T
L
AP
D
-----------
L
Y
L
L
H
-
S
RFP
N
R
Q
R
T
E
I
T
A
T
I
V
D
L
F
G
K
E
G
A
Q
S
GRRPTA--------
V
L
V
A
T
Q
V
V
E
Q
S
L
D
L
-
D
V
D
L
M
I
S
------------
D
L
A
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V
S
L
L
L
Q
R
A
G
R
------------
C
W
R
H
E
H
L
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N
R
P
QW
A
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Q
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L
V
V
L
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P
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A
L
L
Q
R
T
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---
T
---
L
L
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N
G
A
P
V
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I
P
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-------
D
V
Q
Q
L
V
D
D
V
Y
D
D
D
---
S
L
AED
L
-
E
A
D
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M
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L
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--
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P
D
-
P
D
D
A
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D
N
-------
L
N
G
L
T
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H
V
L
A
T
RFGA
G
S
V
R
V
L
C
Y
Y
V
D
TA
G
N
R
W
LDPECTVEFPEQGTGREGRFT
M
A
D
C
R
D
L
V
A
R
T
I
P
V
R
M
G
P
W
A
S
Q
LTEDNHPP
E
A
W
R
E
S
FYLRD
L
V
L
I
P
Q
R
V
T
DAVLPTETGG
R
E
W
L
LDPCKGLIF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
50.54
18%
3
- C2 -
-
4F92
1
U520_HUMAN
B:
[2-1724]
LAPRQVLDLEDLVFTQGSHFMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFGSEEQLLPVEKLPKYAQAGFEGFKTLNRIQSKLYRAALETDENLLLCAPTGAGKTNVALMCMLREIGKHINMDGTINVDDFKIIYIAPMRSLVQEMVGSFGKRLATYGITVAELTGDHQLCKEEISATQIIVCTPEKWDIITRKGGERTYTQLVRLIILDEIHLLHDDRGPVLEALVARAIRNIEMTQEDVRLIGLSATLPNYEDVATFLRVDPAKGLFYFDNSFRPVPLEQTYVGITEKKAIKRFQIMNEIVYEKIMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEKDTLGLFLREGSASTEVLRTEAEQCKNLELKDLLPYGFAIHHAGMTRVDRTLVEDLFADKHIQVLVSTATLAWGVNLPAHTVIIKGTQVYSPEKGRWTELGALDILQMLGRAGRPQYDTKGEGILITSHGELQYYLSLLNQQLPIESQMVSKLPDMLNAEIVLGNVQNAKDAVNWLGYAYLYIRMLRSPTLYGISHDDLKGDPLLDQRRLDLVHTAALMLDKNNLVKYDKKTGNFQVTELGRIASHYYITNDTVQTYNQLLKPTLSEIELFRVFSLSSEFKNITVREEEKLELQKLLERVPIPVKESIEEPSAKINVLLQAFISQLKLEGFALMADMVYVTQLAGRLMRAIFEIVLNRGWAQLTDKTLNLCKMIDKRMWQS
M
C
P
L
R
Q
F
R
K
L
P
E
E
V
V
K
K
I
E
K
K
N
-
F
P
F
E
R
L
Y
D
L
N
H
N
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I
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I
R
M
P
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M
G
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T
I
--
H
K
Y
V
H
L
F
P
K
L
E
L
S
V
H
L
Q
P
-------
I
T
R
----------
S
T
L
K
V
E
L
T
I
T
P
-
D
F
Q
W
D
E
K
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--
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S
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A
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I
L
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-----
D
V
D
S
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L
H
H
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Y
F
L
L
K
A
K
Y
A
Q
D
E
H
-----
L
I
T
F
F
V
P
------------------------------
V
F
E
P
L
P
P
---
Q
Y
F
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R
V
-
V
S
---
D
R
W
L
S
C
E
--------
T
Q
L
P
----
V
S
F
R
H
L
I
L
P
E
K
Y
P
P
P
T
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L
L
D
L
Q
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L
P
V
S
A
L
------
R
--------
N
S
A
F
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S
L
Y
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D
K
F
P
F
F
N
P
I
Q
T
Q
V
F
N
T
V
Y
-----
N
-
S
D
D
N
--------------------
V
F
V
G
A
P
T
G
S
G
K
T
I
C
A
E
F
A
I
L
R
M
L
L
---
Q
------------
S
S
--
E
GR
C
V
Y
I
T
P
M
E
A
L
A
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V
Y
M
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W
Y
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K
F
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D
R-------------
L
------
N
K
K
V
V
L
L
T
G
E
-------
T
S
T
D
L
K
L
L
--
G
K
G
N
--
I
I
----
I
S
T
P
E
K
W
DILSRRW
K
Q
-----
R
----------
K
N
V
Q
N
I
N
L
----
F
V
V
D
E
V
H
L
----
I
G
---
G
---
E
N
G
-------
P
----
V
-
L
EVICSRM
R
Y
I
----
S
-----
S
----
Q
I
-----
E
R
P
I
R
I
V
A
L
S
S
S
L
S
N
A
K
D
V
A
H
--
W
L-
G
C
--------------------
S
A
T
S
T
--------
F
N
F
H
P
N
V
R
P
V
-----
P
L
E
---
L
H
I
Q
G
FNISHTQ
T
-------
R
-----
L
--
L
S
M
A
K
P
V
Y
H
A
--
I
-
T
K
H
S
P
K
K
P
-----------
V
I
----------------
V
F
V
P
S
R
K
Q
T
R
L
----------------------------------------------------
T
A
I
D
I
LTTCAADIQRQRFLHC
T
E
K
D
L
-
I
P
-
Y
L
E
K
L
--
S
DSTLKETLLNG
V
G
Y
L
H
-
E
----
G
L
S
P
M
E
R
R
L
V
E
Q
L
F
S
S
G
A
I
Q
---------------
V
V
V
A
S
R
S
L
C
W
G
M
N
V
A
A
H
L
V
I
I
M
------------
D
T
Q
------
Y
Y
N
G
-----------------
K
I
H
A
Y
V
D
Y
P
--
I
Y
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L
Q
M
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G
H
A
N
-------
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--
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D
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R
C
V
I
M
C
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---
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---
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D
F
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-
F
-
L
Y
E
P
L
-------
P
V
E
---------------------
S
H
L
D
H
----
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M
H
D
H
F
N
A
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I
--
V
T
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T
I
E
N
K
Q
D
A
V
DYLTWTF
L
Y
R
R
M
T
Q
N
P
N
Y
Y
N
L
QGISHRHLSDHLSELVEQTLSDLEQSKCISIEDEMDVAPLNLGMIAAYYYINYTTIELFSMSLNAKTKVRGLIEIISNAAEYENIPIRHHEDNLLRQLAQKVPHKLNNPKFNDPHVKTNLLLQAHLSRMQLSAELQSDTEEILSKAIRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWSKDSYLKQLPHFTSEHIKRCTDKGVESVFDIMEMEDEERNALLQLTDSQIADVARFCNRYPNIELSYEVVDKDSIRSGGPVVVLVQLEREEEVTGPVIAPLFPQKREEGWWVVIGDAKSNSLISIKRLTLQQKAKVKLDFVAPATGAHNYTLYFMSDAYMGCDQEYKFSVD
44
Fugue
45.54
21%
13
- C2 -
-
4NL4
1
?
H:
[18-747]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
A
H
V
A
L
P
V
P
L
P
----------
R
T
F
D
Y
L
-----------------------------
L
P
E
-------
G
M
------------------------------
A
V
K
--
A
G
C
R
V
R
V
P
F
---------
G
K
Q
E
R
I
G
I
V
A
A
V
S
E
R
S
E
L
P
L
D
-----
E
L
K
P
V
A
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A
L
D
D
EP
V
F
S
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T
V
W
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L
L
M
W
A
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G
D
V
L
F
H
A
L
P
V
---
M
L
R
Q
G
K
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A
S
---
A
T
P
L
W
Y
W
--------
F
A
T
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QGQV
V
D
L
N
G
L
K
R
S
R
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Q
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A
L
A
A
L
R
Q
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W
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Q
V
G
E
-
L
E
F
N
--------
E
A
A
L
Q
A
L
R
G
K
G
L
A
E
L
A
C
E
A
T
D
W
R
S
A
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S
VAGER
L
-
R
L
N
T
E
Q
A
T
A
V
G
A
I
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S
--
A
A
D
R
F
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A
W
L
L
A
G
I
T
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S
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E
V
Y
L
S
V
L
E
N
V
L
A
---
Q
------------
G
R
--
Q
--
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
N
A
-----------------------
P
V
E
V
L
H
S
G
--
L
N
D
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
V
----
I
G
T
R
S
S
L
-------
F
T
-----
P
------------
F
K
D
L
G
V
----
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V
I
D
E
E
H
D
----
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S
---
Y
---
K
Q
Q
EGWRYHA
R
----
D
-
L
-------
A
V
W
----
R
-----
A
----
H
S
-----
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Q
I
P
I
I
L
G
S
A
T
P
A
L
E
T
L
H
N
V
R
--
Q
--
G
K
--------------------
Y
R
Q
L
T
--------
L
S
K
-
P
A
Q
Q
H
V
-----
L
D
L
---
K
G
Q
P
L
-------
Q
-------
A
-----
G
LS
P
A
L
I
S
R
M
R
Q
H
--
L
-
Q
A
D
N
Q
V
I
L
FLNRRGFAPAL
L
C
HDCGWIAECPRCDSYY
T
L
H
Q
A
Q
H
H
L
R
C
----------------------------------------------------
H
H
C
D
S
----------------
Q
R
P
I
P
-
R
Q
-
C
P
S
C
G
--
S
-----------
T
H
L
V
P
V
G
----
I
G
T
E
Q
L
E
Q
A
L
A
P
L
F
P
E
V
P
I
S
RIDRHLAAVHRGGAR
I
L
I
G
T
Q
M
L
A
K
G
H
H
F
P
D
V
T
L
V
S
L
LDVDGALFSADF
R
S
A
------
E
R
F
-
A
------------
Q
L
Y
T
Q
V
S
G
R
A
G
R
A
--
G
K
Q
G
E
V
I
L
Q
T
H
H
-------
P
-------
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H
P
L
L
Q
T
L
L
Y
K
G
Y
---
D
---
A
F
--
A
E
-
Q
A
L
A
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R
Q
TMQLPPW
T
S
H
V
L
I
R
A
E
D
H
N
N
---
Q
Q
---
A
-
P
L
F
L
Q
Q
L
R
N
L
L
Q
A
S
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L
A
D
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K
LW
V
L
G
P
V
P
A
L
R
W
Q
I
-------
L
L
Q
H
-
P
S
R
V
R
L
Q
H
I
VSGTLALINTLPEAWVLDVDPIEG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
43.04
21%
-27
- C2 -
-
4NL4
1
?
H:
[210-685]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
-----
L
-
R
L
N
T
E
Q
A
T
A
V
G
A
I
H
S
A
A
--
D
R
F
S
A
W
L
L
A
G
I
T
G
S
G
K
T
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Y
L
S
V
L
E
N
V
L
A
---
Q
------------
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R
--
Q
--
A
L
V
M
V
P
E
I
G
L
T
P
Q
T
I
A
R
F
R
Q
R
F
-----------------------
N
A
P
V
E
V
L
H
S
G
--
L
N
D
S
E
R
L
S
A
W
L
K
A
--
K
N
G
E
A
A
I
V
----
I
G
T
R
S
S
L
-------
F
T
-----------------
P
F
K
D
L
G
V
----
I
V
I
D
E
E
H
D
----
S
S
---
Y
---
K
Q
Q
-------
E
----
G
-
W
-------
R
Y
H
ARDL
A
VWR--
A
----
H
S
-----
E
Q
I
P
I
I
L
G
S
A
T
P
A
L
E
T
L
H
N
V
R
--
Q
--
G
K
--------------------
Y
R
Q
L
T
--------
L
S
K
------
P
-----
A
Q
Q
---
H
V
L
D
L
-------
K
GQPLQAG
L
-----
S
--
P
A
L
I
S
R
M
R
Q
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--
L
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Q
A
D
N
Q
V
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L
-----------
F
L
----------------
N
R
R
G
F
A
P
A
L
L
C
HDCGWIAECPRCDSYYTLHQAQHHLRCHHCDSQRPIPRQCPSCGSTHLVPVG
I
G
T
E
Q
----------------
L
E
Q
A
L
-
A
P
-
L
F
P
E
V
--
P
-----------
I
S
R
I
D
-
R
-------------
H
L
A
A
V
H
R
G
G
A
R
---------------
I
L
I
G
T
Q
M
L
A
K
G
H
H
F
P
D
V
T
L
V
S
L
------------
L
D
V
------
D
G
-
A
L
FSADFRSAERFA
Q
L
Y
T
Q
V
S
G
R
A
G
R
A
--
G
K
Q
G
E
V
I
L
Q
T
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-------
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-----
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H
P
L
L
Q
T
--
L
L
Y
K
G
Y
---
D
---
A
F
A
--
E
-
Q
A
L
A
E
R
---------------
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T
M
Q
L
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---
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---
T
S
H
V
L
I
R
A
E
D
H
N
N
Q
Q
A
P
L
F
L
Q
Q
--
L
R
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
41.43
18%
-4
- C2 -
-
4U7D
-
RECQ1_HUMAN
C:
[29-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
K
V
K
D
I
L
Q
N
V
F
K
-----
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
------
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
------
S
------------
D
G
--
F
--
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
------------------------
G
I
S
A
T
M
L
N
A
S
--
S
S
K
E
H
V
K
W
V
H
A
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K
N
S
E
L
K
L
I
----
Y
V
T
P
E
K
I
-------
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-----
S
KMFMSRLEKA
Y
E
A
R
R
F
T
R
----
I
A
V
D
E
V
H
C
----
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S
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H
---
D
F
R
-------
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----
D
-
Y
-------
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A
L
----
G
IL---
K
R---
Q
F
-----
P
N
A
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
--
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I-
L
C
--------------------
I
E
K
C
F
--------
T
F
T
A
S
F
N
R
P
N
-----
L
Y
Y
---
E
V
R
Q
K
-------
P
S------
N
TEDF-
I
--
E
D
I
V
K
L
I
N
G
R
----
Y
K
G
Q
S
G
I
I
-----------
Y
C
----------------
F
--------
S
Q
----------------------------------------------------
K
D
S
E
Q
----------------
V
T
V
S
L
-
Q
N
---
L
G
I
--
H
-----------
A
G
A
Y
H
-
A
----
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
---------------
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
------------
H
S
M
------
S
K
-
S
M
------------
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
--
D
M
K
A
D
C
I
L
Y
Y
G
F
-------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
41.18
18%
-7
- C2 -
-
2V1X
1
RECQ1_HUMAN
A:
[28-377]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
S
G
K
V
K
D
I
L
Q
N
V
F
K
-----
L
E
K
F
R
P
L
Q
L
E
T
I
N
V
T
M
A
G
------
K
E
V
F
L
V
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
A
L
C
------
S
------------
D
G
--
F
--
T
L
V
I
C
P
L
I
S
L
M
E
D
Q
L
M
V
L
K
Q
L
------------------------
G
I
S
A
T
M
L
N
A
S
--
S
S
K
E
H
V
K
W
V
H
A
E
M
V
N
K
N
S
E
L
K
L
I
----
Y
V
T
P
E
K
I
-------
A
K
-----
S
K
M
F
M
S
R
L
E
K
A
Y
E
A
R
R
F
T
R
----
I
A
V
D
E
V
H
C
----
C
S
QWG
H
---
D
F
R
-------
P
----
D
-
Y
-------
K
A
L
----
G
I
L
---
K
R
---
Q
F
-----
P
N
A
S
L
I
G
L
T
A
T
A
T
N
H
V
L
T
D
A
Q
K
I
L
--
C
I
--------------------
E
K
C
F
T
--------
F
-
T
A
S
F
N
R
P
N
-----
L
Y
Y
---
E
V
R
Q
K
-------
P
-------
S
N
T
E
D
F
I
--
E
D
I
V
K
L
I
N
G
R
----
Y
K
G
Q
S
G
I
I
-----------
Y
C
----------------
F
--------
S
Q
----------------------------------------------------
K
D
S
E
Q
----------------
V
T
V
S
L
-
Q
N
---
L
G
I
--
H
-----------
A
G
A
Y
H
-
A
----
N
L
E
P
E
D
K
T
T
V
H
R
K
W
S
A
N
E
I
Q
---------------
V
V
V
A
T
V
A
F
G
M
G
I
D
K
P
D
V
R
F
V
I
H
------------
H
S
M
------
S
K
-
S
M
------------
E
N
Y
Y
Q
E
S
G
R
A
G
R
D
--
D
M
K
A
D
C
I
L
Y
Y
G
F
-------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
40.64
42%
-259
- C2 -
-
5JBG
2
?
A:
[419-458]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
Q
N
E
Q
Q
D
V
I
T
L
F
R
Y
G
E
L
N
---------------
L
L
F
S
T
S
V
A
E
E
G
L
D
I
P
E
C
N
I
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
40.32
42%
-255
- C2 -
-
5JB2
2
?
A:
[419-458]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
Q
N
E
Q
Q
D
V
I
T
L
F
R
Y
G
E
L
N
---------------
L
L
F
S
T
S
V
A
E
E
G
L
D
I
P
E
C
N
I
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
40.15
19%
-6
- C2 -
-
4Q48
-
?
B:
[10-343]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
A
L
H
L
L
Q
T
I
W
G
-----
Y
P
A
F
R
G
V
Q
G
E
I
V
Q
Q
V
A
E
G
------
G
N
A
L
V
L
M
P
T
G
G
G
K
S
L
C
Y
Q
L
P
S
L
L
R
------------------
P
G
--
T
--
G
I
V
V
S
P
L
I
A
L
M
K
D
Q
V
D
T
L
R
Q
N
G
------------------------
V
R
A
A
F
L
N
S
T
--
L
L
P
H
E
A
R
E
V
E
D
A
L
--
L
R
G
D
L
D
L
L
----
Y
V
A
P
E
R
L
-------
L
M
PRTLD
L
----------
L
E
R
A
P
V
A
L
----
F
A
I
D
E
A
H
C
----
V
S
---
Q
WGH
D
F
R
-------
P
----
E
-
Y
-------
Q
Q
L
SVL-
A
-----
E
----
R
F
-----
P
E
L
P
R
V
A
L
T
A
T
A
D
E
R
T
R
A
D
I
K
--
S
VL
R
L
--------------------
E
D
A
P
Q
--------
F
-
V
S
S
F
D
R
P
N
-----
I
Q
Y
---
R
V
G
L
K
-------
D
S------
P
-----
K
--
T
Q
L
L
H
F
I
R
E
E
----
H
P
G
D
A
G
I
V
-----------
Y
C
----------------
L
--------
S
R
----------------------------------------------------
K
S
V
E
E
----------------
T
A
K
W
L
-
Q
A
-
Q
--
G
I
--
D
-----------
A
L
A
Y
H
-
A
----
G
L
S
S
T
E
R
N
N
V
Q
E
R
F
L
N
E
E
G
V
---------------
I
V
C
A
T
V
A
-----
D
K
P
N
V
R
F
V
A
H
------------
L
D
L
------
P
K
-
S
M
------------
E
G
Y
Y
Q
E
T
G
R
A
G
R
D
--
G
L
P
S
T
A
W
M
V
Y
G
L
-------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
HHSearch
39.48
20%
-5
- C2 -
-
4D26
2
?
A:
[68-408]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
-----
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
------
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
---
Q
D
P
K
D
L
I
S
E
NG
C
A
Q
P
--
Q
--
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
--------------
S
------
V
L
K
V
A
V
A
Y
G
G
--
T
A
V
R
H
Q
---
G
D
N
I
---
A
R
G
C
H
I
L
----
V
A
T
P
G
R
L
-------
H
D
-----
F
V
E
R
NR-----
V
S
F
G
S
V
R
F
----
V
V
L
D
Q
A
D
C
----
M
L
---
D
---
M
G
F
-------
M
P
---
S
-
I
-------
E
K
M
----
M
L
HPTM
V
----
E
T
-----
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
--
R
F
L
N
N
--------------------
Y
L
F
V
A
--------
V
G
I
V
G
G
A
S
T
D
-----
V
E
Q
I
F
I
E
V
T
K
Y
-------
E
-------
K
-----
R
--
N
S
L
K
Q
L
I
E
E
N
-----
D
G
K
R
I
L
V
-----------
F
V
----------------
E
--------
T
K
----------------------------------------------------
R
N
A
D
F
----------------
I
A
A
M
L
-
S
E
---
Q
Q
L
--
L
-----------
T
S
S
I
H
-
G
----
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
---------------
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
------------
Y
D
L
------
P
-
K
S
I
------------
D
E
Y
V
H
R
I
G
R
T
G
R
V
--
G
N
R
G
K
A
V
S
F
Y
D
S
-------
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
39.05
42%
-265
- C2 -
-
5JAJ
3
?
A:
[420-459]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
Q
N
E
Q
Q
D
V
I
T
L
F
R
Y
G
E
L
N
---------------
L
L
F
S
T
S
V
A
E
E
G
L
D
I
P
E
C
N
I
V
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
39.03
17%
-8
- C2 -
-
5IVL
-
?
B:
[18-350]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
M
G
-----
F
E
E
T
T
P
I
Q
A
K
T
I
P
L
S
L
Q
N
------
K
D
V
I
G
Q
A
Q
T
G
T
G
K
T
A
A
F
G
I
P
I
V
E
K
V
D
VKN
G
------------
A
I
--
Q
--
A
L
V
V
A
P
T
R
E
L
A
I
Q
V
S
E
E
L
Y
K
I
G
A
V
--------------
K
------
R
V
R
V
L
P
I
Y
G
G
--
Q
D
I
E
R
Q
I
---
R
A
L
---
K
K
H
P
H
V
I
----
V
G
T
P
G
R
I
-------
I
D
-----
H
I
N
R
GT-----
L
R
L
E
H
V
H
T
----
V
V
L
D
E
A
D
E
----
M
L
--------
G
F
-------
I
----
E
D
I
-------
E
A
I
----
L
-----
S
H
---
V
P
-----
A
E
R
Q
T
L
L
F
S
A
T
M
P
D
P
I
R
R
I
A
E
--
R
FM
N
E
--------------------
P
E
L
V
K
--------
V
K
A
----
V
P
N
-----
I
Q
Q
---
Y
Y
L
E
V
-------
H
-------
E
--------
K
K
K
F
D
I
L
T
R
L
L
D
I
-
Q
A
P
E
L
A
I
V
-----------
F
G
----------------
R
--------
T
K
----------------------------------------------------
R
R
V
D
E
----------------
L
A
E
A
L
-
N
L
---
R
G
Y
--
A
-----------
A
E
G
I
H
-
G
----
D
L
S
Q
A
K
R
L
S
V
L
R
K
F
K
E
G
A
I
E
---------------
I
L
V
A
T
D
V
A
A
R
G
L
D
I
S
G
V
T
H
V
Y
N
------------
F
D
I
------
P
-
Q
D
P
------------
E
S
Y
V
H
R
I
G
R
T
G
R
A
--
G
K
T
G
V
A
M
T
F
V
T
P
-------
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
38.88
19%
-16
- C2 -
-
1OYW
-
RECQ_ECOLI
A:
[13-343]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
Q
V
L
Q
E
T
F
G
-----
Y
Q
Q
F
R
P
G
Q
E
E
I
I
D
T
V
L
S
G
------
R
D
C
L
V
V
M
P
T
G
G
G
K
S
L
C
Y
Q
I
P
A
L
L
L
------------------
N
G
--
L
--
T
V
V
V
S
P
L
I
S
L
M
K
D
Q
V
D
Q
L
Q
A
N
------------------------
G
V
A
A
A
C
L
N
S
T
--
Q
T
R
E
Q
Q
L
E
V
M
T
G
C
--
R
T
G
Q
I
R
L
L
----
Y
I
A
P
E
R
L
-------
M
L
DN
F
L
E
H
----------
L
A
H
W
N
P
V
L
----
L
A
V
D
E
A
H
C
----
I
S
---
Q
WGH
D
F
R
-------
P
----
E
-
Y
-------
A
A
L
GQ--
L
-----
R
Q
---
R
F
-----
P
T
L
P
F
M
A
L
T
A
T
A
D
D
T
T
R
Q
D
I
V
--
R
L
-
L
G
--------------------
L
N
D
P
L
--------
I
Q
I
S
S
F
D
R
P
N
-----
I
R
Y
---
M
L
M
E
K
-------
F
K------
P
-----
L
--
D
Q
L
M
R
Y
V
Q
E
-----
Q
R
G
K
S
G
I
I
-----------
Y
C
----------------
N
--------
S
R
----------------------------------------------------
A
K
V
E
D
----------------
T
A
A
R
L
-
Q
S
-
K
--
G
I
--
S
-----------
A
A
A
Y
H
-
A
----
G
L
E
N
N
V
R
A
D
V
Q
E
K
F
Q
R
D
D
L
Q
---------------
I
V
V
A
T
V
A
F
G
M
G
I
N
K
P
N
V
R
F
V
V
H
------------
F
D
I
------
P
-
R
N
I
------------
E
S
Y
Y
Q
E
T
G
R
A
G
R
D
--
G
L
P
A
E
A
M
L
F
Y
D
P
-------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
38.53
19%
17
- C2 -
-
4W7S
6
PRP28_YEAST
A:
[60-419]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
V
I
I
Q
E
L
R
-----
F
P
S
P
T
P
I
Q
R
I
T
I
P
N
V
C
N
M
K
---
Q
Y
R
D
F
L
G
V
A
S
T
G
S
G
K
T
L
A
F
V
I
P
I
L
I
K
M
S
---
R
S
PPRP
P
S
L
K
I
I
D
G
P
--
K
--
A
L
I
L
A
P
T
R
E
L
V
Q
Q
I
Q
K
E
T
Q
K
V
T
K
I
--------------
W
S
K
E
SNY
D
C
K
V
I
S
I
V
G
G
--
H
S
L
E
E
I
----
S
F
S
--
L
S
E
G
C
D
I
L
----
V
A
T
P
G
R
L
-------
I
D
-----
S
L
E
N
HL-----
L
V
M
K
Q
V
E
T
----
L
V
L
D
E
A
D
K
----
M
I
---
D
---
L
G
F
-------
E
D
Q
V
T
N
-
I
-------
L
T
K
----
V
-----
D
I
N
AD
S
A
-----
V
N
R
Q
T
L
M
F
T
A
T
M
T
P
V
I
E
K
I
A
A
--
G
YM
Q
K
--------------------
P
V
Y
A
T
--------
I
G
V
E
T
G
S
E
P
L
-----
I
Q
Q
---
V
V
E
Y
A
-------
D
-------
N
-----
D
--
E
D
K
F
K
K
L
K
P
I
--
V
A
K
Y
D
P
P
I
I
I
-----------
F
I
----------------
N
--------
Y
K
----------------------------------------------------
Q
T
A
D
W
----------------
L
A
E
K
F
-
Q
K
-
E
T
-
N
M
--
K
-----------
V
T
I
L
H
-
G
----
S
K
S
Q
E
Q
R
E
H
S
L
Q
L
F
R
T
N
K
V
Q
---------------
I
M
I
A
T
N
V
A
A
R
G
L
D
I
P
N
V
S
L
V
V
N
------------
F
Q
I
------
S
-
K
K
M
------------
D
D
Y
I
H
R
I
G
R
T
G
R
A
--
A
N
E
G
T
A
V
S
F
V
S
A
-------
A
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