@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQQ3: (2017-11-28 )
MNALTQELVELLTLEKLEENIYRGISRNLVGKRVFGGQVLGQALRAASYTTDRPAHSLHAYFLYGGDINAPIIYEVDRLRDGKSFVSRQVRAIQHGRVIFSAMVSFANPEEGLNYQHPEPDYPAPEALKSESELKEGILNFVPENVRASFMRERHVEIRPIDPVNPFQPQPEAPFNAHYIRTHDRIPKQLEDISLHQAIVAFYSDFTLMTTALRPHGLSYISPSLQCASIDHAIYFHRPLRADEWMLYDMEATVSAASRGLNFGRMWQNGQLVCSTVQEGLMRLREIETQ
Atome Classification :
(20 SA)
.........10.-.......20.......-.30-----.-.......40........50-.--........60........70........80........90........100.....-..110-....-.--..120.......130..----.....140......--.150.......160.....---..-170......--.180.......190.......200.......210.......220...-....230.......240----........250.......260.....-..270.......280.......290
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MN
A
L
T
Q
E
L
V
E
L
L
-
T
L
E
K
L
E
E
N
I
Y
R
G
I
S
R
N
-
L
V
G-----K-RVF
G
G
Q
V
L
G
Q
A
L
R
AASYT--T--DRPAH
S
L
H
A
Y
F
L
YGGDINA
P
I
I
Y
E
V
D
R
LRD
G
K
S
F
V
S
R
Q
V
R
A
I
QH
G
R
V
I
F
S
A
M
V
SFA-
N
P
EEG-LNYQ-H--PEPDYPA
P
E
A
L
K
S
E
S
E
L
----
K
E
G
I
L
N
FV
P
E
N
V
R
A
--
S
F
M
R
ERH
V
E
I
R
PIDPVNPF---QP-QPEAPFN
A
H
--
Y
I
R
T
H
D
RI
P
K
Q
L
E
D
I
S
L
H
Q
A
I
V
A
F
Y
SD
F
T
L
M
T
TALRPHGLSYISPS
L
-
Q
C
ASID
H
A
I
Y
FHRPLR-----AD
E
W
M
L
Y
D
M
E
A
T
V
S
A
A
S
RGLNFGRMW-QNGQ
L
V
C
S
T
V
Q
E
G
L
M
R
L
R
E
IETQ
16
HHSearch
86.38
42%
-27
- C6 -
-
1C8U
1
TESB_ECOLI
A:
[3-284]
---
A
L
K
N
L
L
T
L
L
-
N
L
E
K
I
E
E
G
L
F
R
G
Q
S
E
D
-
L
G
L
-----
R
-
Q
V
F
G
G
Q
V
V
G
Q
A
L
Y
A
A
K
E
T
--
V
PE
E
R
L
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
K
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
A
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
A
P
E
A
G
-
F
E
H
Q
-
K
--
T
M
P
S
A
P
A
P
D
G
L
P
S
E
T
Q
I
----
A
Q
S
L
A
H
L
L
P
P
V
L
K
D
KF
I
C
--
D
R
P
L
E
V
R
P
V
E
F
H
N
P
L
---
K
G
-
H
V
A
E
P
H
R
Q
V
--
W
I
R
A
N
G
S
V
P
D
---
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
L
N
F
L
P
V
A
L
Q
P
H
G
I
G
F
L
-
E
P
G
I
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
N
-----
L
N
E
W
L
L
Y
S
V
E
S
T
S
A
S
S
A
R
G
F
V
R
G
E
F
Y
T
Q
D
G
V
L
V
A
S
T
V
Q
E
G
V
M
R
N
H
-----
38
Fugue
85.17
42%
-18
- C6 -
-
1C8U
1
TESB_ECOLI
A:
[1-285]
-
S
Q
A
L
K
N
L
L
T
L
L
-
N
L
E
K
I
E
E
G
L
F
R
G
Q
S
E
D
-
L
G
L
-----
R
-
Q
V
F
G
G
Q
V
V
G
Q
A
L
Y
A
A
K
E
T
VP
E
--
E
R
L
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
K
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
A
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
A
P
E
A
G
-
F
E
H
Q
-
K
--
T
M
P
S
A
P
A
P
D
G
L
P
S
E
T
Q
I
----
A
Q
S
L
A
H
L
L
P
P
V
L
K
D
--
K
F
I
C
D
R
P
L
E
V
R
P
V
E
F
H
N
P
L
---
K
G
-
H
V
A
E
P
H
R
Q
V
--
W
I
R
A
N
G
S
V
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
L
N
F
L
P
V
A
L
Q
P
H
G
I
G
F
L
E
P
G
I
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
N
-----
L
N
E
W
L
L
Y
S
V
E
S
T
S
A
S
S
A
R
G
F
V
R
G
E
F
Y
T
Q
D
G
V
L
V
A
S
T
V
Q
E
G
V
M
R
N
H
N
----
10
PsiBlast_CBE
83.34
43%
-22
- C6 -
-
4R4U
2
?
D:
[20-287]
-----------------
I
E
E
G
I
F
R
G
Q
S
E
----------
R
-
Q
V
F
G
G
Q
V
V
G
Q
A
I
Y
A
A
K
Q
T
--
V
PA
E
R
T
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
S
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
S
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
S
Q
E
E
G
-
F
E
H
Q
-
N
--
T
M
P
D
V
P
P
P
E
G
L
M
S
E
T
D
I
----
A
R
Q
----------------
G
P
Q
P
I
E
M
R
P
V
K
F
H
N
P
L
---
Q
G
-
S
V
E
E
P
N
R
Y
V
--
W
F
R
A
N
G
K
M
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
F
N
F
L
P
T
A
L
Q
P
H
G
I
G
F
L
E
P
G
M
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
R
-----
L
D
D
W
L
L
Y
A
V
E
S
T
S
A
S
G
A
R
G
F
V
R
G
Q
I
Y
N
R
E
G
V
L
V
A
S
T
V
Q
E
G
V
I
R
L
------
2
PsiBlast_PDB
83.28
43%
-20
- C6 -
-
4R4U
1
?
A:
[20-287]
-----------------
I
E
E
G
I
F
R
G
Q
S
E
D
-
L
---------
Q
V
F
G
G
Q
V
V
G
Q
A
I
Y
A
A
K
Q
T
--
V
PA
E
R
T
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
S
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
S
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
S
Q
E
E
G
-
F
E
H
Q
-
N
--
T
M
P
D
V
P
P
P
E
G
L
M
S
E
T
D
I
----
A
R
Q
F
----
P
E
K
V
R
E
--
K
F
I
G
P
Q
P
I
E
M
R
P
V
K
F
H
N
P
L
---
Q
G
-
S
V
E
E
P
N
R
Y
V
--
W
F
R
A
N
G
K
M
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
F
N
F
L
P
T
A
L
Q
P
H
G
I
G
F
L
E
P
G
M
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
R
-----
L
D
D
W
L
L
Y
A
V
E
S
T
S
A
S
G
A
R
G
F
V
R
G
Q
I
Y
N
R
E
G
V
L
V
A
S
T
V
Q
E
G
V
I
R
L
------
11
PsiBlast_CBE
82.84
43%
-24
- C6 -
-
4R4U
2
?
C:
[20-287]
-----------------
I
E
E
G
I
F
R
G
Q
S
E
D
-
L
G
L
-----
R
-
Q
V
F
G
G
Q
V
V
G
Q
A
I
Y
A
A
K
Q
T
--
V
PA
E
R
T
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
S
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
S
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
S
Q
E
E
G
-
F
E
H
Q
-
N
--
T
M
P
D
V
P
P
P
E
G
L
M
S
E
T
D
I
----
A
R
Q
F
S
--------------
G
P
Q
P
I
E
M
R
P
V
K
F
H
N
P
L
---
Q
G
-
S
V
E
E
P
N
R
Y
V
--
W
F
R
A
N
G
K
M
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
F
N
F
L
P
T
A
L
Q
P
H
G
I
G
F
L
E
P
G
M
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
R
-----
L
D
D
W
L
L
Y
A
V
E
S
T
S
A
S
G
A
R
G
F
V
R
G
Q
I
Y
N
R
E
G
V
L
V
A
S
T
V
Q
E
G
V
I
R
L
------
12
PsiBlast_CBE
82.70
43%
-23
- C6 -
-
4R4U
1
?
B:
[20-287]
-----------------
I
E
E
G
I
F
R
G
Q
S
E
------------
Q
V
F
G
G
Q
V
V
G
Q
A
I
Y
A
A
K
Q
T
--
V
PA
E
R
T
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
S
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
S
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
S
Q
E
E
G
-
F
E
H
Q
-
N
--
T
M
P
D
V
P
P
P
E
G
L
M
S
E
T
D
I
----
A
R
Q
----------------
G
P
Q
P
I
E
M
R
P
V
K
F
H
N
P
L
---
Q
G
-
S
V
E
E
P
N
R
Y
V
--
W
F
R
A
N
G
K
M
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
F
N
F
L
P
T
A
L
Q
P
H
G
I
G
F
L
E
P
G
M
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
R
-----
L
D
D
W
L
L
Y
A
V
E
S
T
S
A
S
G
A
R
G
F
V
R
G
Q
I
Y
N
R
E
G
V
L
V
A
S
T
V
Q
E
G
V
I
R
L
------
13
PsiBlast_CBE
81.55
42%
-17
- C6 -
-
1C8U
1
TESB_ECOLI
B:
[14-282]
---------------
E
K
I
E
E
G
L
F
R
G
Q
S
E
D
-
L
G
L
-----
R
-
Q
V
F
G
G
Q
V
V
G
Q
A
L
Y
A
A
K
E
T
--
V
PE
E
R
L
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
K
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
A
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
A
P
E
A
G
-
F
E
H
Q
-
K
--
T
M
P
S
A
P
A
P
D
G
L
P
S
E
T
Q
I
----
A
Q
S
L
A
H
L
L
P
P
V
L
K
D
--
K
F
I
C
D
R
P
L
E
V
R
P
V
E
F
H
N
P
L
---
K
G
-
H
V
A
E
P
H
R
Q
V
--
W
I
R
A
N
G
S
V
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
L
N
F
L
P
V
A
L
Q
P
H
G
I
G
F
L
E
P
G
I
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
N
-----
L
N
E
W
L
L
Y
S
V
E
S
T
S
A
S
S
A
R
G
F
V
R
G
E
F
Y
T
Q
D
G
V
L
V
A
S
T
V
Q
E
G
V
M
R
-------
1
PsiBlast_PDB
81.44
43%
-25
- C6 -
-
4QFW
-
?
A:
[17-284]
-----------------
I
E
E
G
I
F
R
G
Q
S
E
------------
Q
V
F
G
G
Q
V
V
G
Q
A
I
Y
A
A
K
Q
T
--
V
PA
E
R
T
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
S
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
S
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
S
Q
E
E
G
-
F
E
H
Q
-
N
--
T
M
P
D
V
P
P
P
E
G
L
M
S
E
T
D
I
----
A
R
Q
----------------
G
P
Q
P
I
E
M
R
P
V
K
F
H
N
P
L
---
Q
G
-
S
V
E
E
P
N
R
Y
V
--
W
F
R
A
N
G
K
M
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
F
N
F
L
P
T
A
L
Q
P
H
G
I
G
F
L
E
P
G
M
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
R
-----
L
D
D
W
L
L
Y
A
V
E
S
T
S
A
S
G
A
R
G
F
V
R
G
Q
I
Y
N
R
E
G
V
L
V
A
S
T
V
Q
E
G
V
I
R
L
------
3
PsiBlast_PDB
81.34
42%
-17
- C6 -
-
1C8U
1
TESB_ECOLI
A:
[14-282]
---------------
E
K
I
E
E
G
L
F
R
G
Q
S
E
D
-
L
G
L
-----
R
-
Q
V
F
G
G
Q
V
V
G
Q
A
L
Y
A
A
K
E
T
--
V
PE
E
R
L
V
H
S
F
H
S
Y
F
L
R
P
G
D
S
K
K
P
I
I
Y
D
V
E
T
L
R
D
G
N
S
F
S
A
R
R
V
A
A
I
Q
N
G
K
P
I
F
Y
M
T
A
S
F
Q
-
A
P
E
A
G
-
F
E
H
Q
-
K
--
T
M
P
S
A
P
A
P
D
G
L
P
S
E
T
Q
I
----
A
Q
S
L
A
H
L
L
P
P
V
L
K
D
--
K
F
I
C
D
R
P
L
E
V
R
P
V
E
F
H
N
P
L
---
K
G
-
H
V
A
E
P
H
R
Q
V
--
W
I
R
A
N
G
S
V
P
---
D
D
L
R
V
H
Q
Y
L
L
G
Y
A
S
D
L
N
F
L
P
V
A
L
Q
P
H
G
I
G
F
L
E
P
G
I
-
Q
I
A
T
I
D
H
S
M
W
F
H
R
P
F
N
-----
L
N
E
W
L
L
Y
S
V
E
S
T
S
A
S
S
A
R
G
F
V
R
G
E
F
Y
T
Q
D
G
V
L
V
A
S
T
V
Q
E
G
V
M
R
-------
15
HHSearch
74.72
30%
-37
- C6 -
-
3RD7
-
?
B:
[3-284]
M
I
S
T
L
E
D
V
L
S
L
L
-
D
L
Q
Q
I
D
D
A
A
F
V
G
T
Q
P
D
-
T
P
N
-----
H
-
H
I
I
G
S
Q
V
A
A
Q
A
L
M
A
A
G
R
T
--
T
P-
G
R
L
A
H
S
M
H
M
Y
F
L
R
R
G
D
A
R
Q
P
I
Q
Y
D
V
T
P
L
R
D
G
G
T
I
S
S
R
R
V
T
A
S
Q
S
G
V
V
L
F
E
A
L
A
S
F
T
-
I
I
A
D
D
-
V
D
W
Q
-
Q
--
R
M
P
D
V
A
G
P
S
A
V
H
G
L
E
D
L
----
L
A
P
Y
A
E
E
F
------------
Q
R
P
F
T
M
R
Y
L
D
A
P
P
R
V
ALD
L
S
-
D
P
P
P
P
R
L
R
I
--
W
L
R
A
N
G
E
V
T
D
---
D
P
L
V
N
S
C
V
V
A
Y
L
S
A
L
T
L
L
E
C
V
M
T
T
M
R
T
T
P
--
V
G
P
R
L
S
A
L
V
D
H
T
I
W
F
H
R
A
A
D
-----
F
T
D
W
L
L
F
D
Q
F
S
P
S
I
V
G
R
R
G
L
A
T
G
T
L
Y
N
R
S
G
E
L
V
C
I
A
T
Q
E
G
Y
F
A
E
Q
-----
18
HHSearch
74.70
37%
-22
- C6 -
-
3U0A
-
?
B:
[5-280]
-----
M
A
I
E
E
I
L
-
D
L
E
Q
L
E
V
N
I
Y
R
G
S
---------------
T
F
G
G
H
V
A
G
Q
S
L
V
S
A
V
R
T
--
V
DP
R
Y
Q
V
H
S
L
H
G
Y
F
L
R
S
G
D
A
Q
E
P
T
V
F
L
V
E
R
T
R
D
G
G
S
F
V
T
R
R
V
N
A
V
Q
H
G
E
V
I
F
S
M
G
A
S
F
Q
-
T
A
Q
N
G
-
I
S
H
Q
-
D
--
A
M
P
A
A
P
P
P
--
L
P
G
L
---------------------------
F
E
E
W
D
V
R
I
V
P
R
D
-
L
L
---
A
P
L
P
G
K
A
S
Q
Q
Q
V
--
W
F
R
H
R
D
P
L
P
D
---
D
P
V
L
H
I
C
A
L
A
Y
M
S
D
L
T
L
L
G
S
A
Q
V
T
H
L
A
E
---
R
E
H
L
Q
V
A
S
L
D
H
A
M
W
F
M
R
G
F
R
-----
A
D
E
W
L
L
Y
D
Q
S
S
P
S
A
G
G
G
R
A
L
T
H
G
K
I
F
T
Q
G
G
E
L
V
A
A
V
M
Q
E
G
L
T
R
Y
P
S
G
Y
--
14
HHSearch
72.56
30%
-38
- C6 -
-
3RD7
-
?
A:
[3-283]
M
I
S
T
L
E
D
V
L
S
L
L
-
D
L
Q
Q
I
D
D
A
A
F
V
G
T
Q
P
D
-
T
P
N
-----
H
-
H
I
I
G
S
Q
V
A
A
Q
A
L
M
A
A
G
R
T
--
T
P-
G
R
L
A
H
S
M
H
M
Y
F
L
R
R
G
D
A
R
Q
P
I
Q
Y
D
V
T
P
L
R
D
G
G
T
I
S
S
R
R
V
T
A
S
Q
S
G
V
V
L
F
E
A
L
A
S
F
T
-
I
I
A
D
D
-
V
D
W
Q
-
Q
--
R
M
P
D
V
A
G
P
S
A
V
H
G
L
E
D
L
----
L
A
P
Y
A
E
E
F
------------
Q
R
P
F
T
M
R
Y
L
D
A
P
P
R
V
A
L
D
L
S
-
D
P
P
P
P
R
L
R
I
--
W
L
R
A
N
G
E
V
T
D
---
D
P
L
V
N
S
C
V
V
A
Y
L
S
A
L
T
L
L
E
C
V
M
T
T
M
R
T
T
P
--
V
G
P
R
L
S
A
L
V
D
H
T
I
W
F
H
R
A
A
D
-----
F
T
D
W
L
L
F
D
Q
F
S
P
S
I
V
G
R
R
G
L
A
T
G
T
L
Y
N
R
S
G
E
L
V
C
I
A
T
Q
E
G
Y
F
A
E
------
4
PsiBlast_PDB
70.83
31%
-27
- C6 -
-
3RD7
-
?
A:
[3-279]
M
I
S
T
L
E
D
V
L
S
L
L
-
D
L
Q
Q
I
D
D
A
A
F
V
G
T
Q
P
D
-
T
P
N
-----
H
-
H
I
I
G
S
Q
V
A
A
Q
A
L
M
A
A
G
R
T
--
T
P-
G
R
L
A
H
S
M
H
M
Y
F
L
R
R
G
D
A
R
Q
P
I
Q
Y
D
V
T
P
L
R
D
G
G
T
I
S
S
R
R
V
T
A
S
Q
S
G
V
V
L
F
E
A
L
A
S
F
T
-
I
I
A
D
D
-
V
D
W
Q
-
Q
--
R
M
P
D
V
A
G
P
S
A
V
H
G
L
E
D
L
L
APY
A
E
E
F
------
Q
-
R
P
--
F
T
M
--
R
Y
L
D
A
P
P
R
V
A
L
D
L
S
---
D
P
-
P
P
--
P
R
L
R
I
--
W
L
R
A
N
G
E
V
---
T
D
D
P
L
V
N
S
C
V
V
A
Y
L
S
A
L
T
L
L
E
C
V
M
T
T
M
R
T
T
P
V
G
P
R
L
-
S
-
A
L
V
D
H
T
I
W
F
H
R
A
A
D
-----
F
T
D
W
L
L
F
D
Q
F
S
P
S
I
V
G
R
R
G
L
A
T
G
T
L
Y
N
R
S
G
E
L
V
C
I
A
T
Q
E
G
----------
20
HHSearch
70.48
29%
-15
- C6 -
-
4R9Z
-
?
B:
[3-272]
--
S
S
L
G
D
V
L
A
T
L
-
E
L
E
R
V
G
Q
W
R
F
V
G
Q
Q
L
P
-
A
P
A
-----
N
-
H
I
L
G
G
H
I
S
A
Q
A
L
L
A
A
S
R
T
--
A
A-
G
R
E
P
H
S
V
H
T
Y
F
L
R
P
G
D
S
R
Q
P
V
D
F
E
V
V
D
L
Q
E
G
R
T
F
S
A
R
R
V
T
A
R
Q
D
D
K
I
L
M
E
A
M
S
S
F
K
-
V
V
N
--Q
V
V
Y
Q
-
P
--
I
M
P
E
A
P
S
P
E
S
-----------------------
W
---
A
S
--
L
R
W
F
E
R
R
T
I
E
T
E
---------
T
V
P
P
A
R
V
P
M
--
W
W
R
P
D
G
R
V
P
D
---
D
P
V
L
T
A
S
L
V
A
Y
M
S
A
V
T
L
T
E
P
A
F
A
A
R
------
G
G
V
G
A
S
A
Q
R
D
H
S
V
W
F
H
G
R
A
V
-----
L
S
D
W
L
F
Y
D
R
S
S
P
S
S
A
G
S
L
A
L
A
S
G
T
M
F
N
R
T
G
E
L
V
C
T
V
K
Q
E
M
Y
F
P
P
------
19
HHSearch
67.39
29%
-18
- C6 -
-
4R9Z
-
?
A:
[4-272]
---
S
L
G
D
V
L
A
T
L
-
E
L
E
R
V
G
Q
W
R
F
V
G
Q
Q
L
P
-
A
P
A
-----
N
-
H
I
L
G
G
H
I
S
A
Q
A
L
L
A
A
S
R
T
--
A
A-
G
R
E
P
H
S
V
H
T
Y
F
L
R
P
G
D
S
R
Q
P
V
D
F
E
V
V
D
L
Q
E
G
R
T
F
S
A
R
R
V
T
A
R
Q
D
D
K
I
L
M
E
A
M
S
S
F
K
-
V
----Q
V
V
Y
Q
-
P
--
I
M
P
E
A
P
S
P
E
S
L
--------------------------
A
S
--
L
R
W
F
E
R
R
T
I
E
T
E
---------
T
V
P
P
A
R
V
P
M
--
W
W
R
P
D
G
R
V
P
D
---
D
P
V
L
T
A
S
L
V
A
Y
M
S
A
V
T
L
T
E
P
A
F
A
A
R
------
G
G
V
G
A
S
A
Q
R
D
H
S
V
W
F
H
G
R
A
V
-----
L
S
D
W
L
F
Y
D
R
S
S
P
S
S
A
G
S
L
A
L
A
S
G
T
M
F
N
R
T
G
E
L
V
C
T
V
K
Q
E
M
Y
F
P
P
------
6
PsiBlast_PDB
61.18
21%
-42
- C6 -
-
3CJY
7
?
A:
[35-258]
-----------------------------------------
L
F
G
G
A
S
M
A
L
A
L
D
V
A
A
E
T
--
V
--
G
R
P
V
V
Q
G
S
L
Q
F
V
S
F
T
P
L
G
S
V
L
D
L
T
V
E
V
L
Q
S
G
R
T
L
A
Q
A
R
V
A
G
T
V
D
G
R
L
V
F
H
S
G
I
S
L
G
-
M
-
R
E
G
-
F
S
A
R
-
Q
WA
L
A
P
P
V
P
Q
P
D
N
C
P
P
C
T
T
L
----
P
A
-------
Q
D
D
N
A
--
R
Y
L
--
E
G
I
E
V
R
E
A
G
-----------
G
P
E
V
P
S
G
R
T
R
L
W
L
R
R
K
D
G
A
P
-------
L
D
A
A
S
L
A
M
F
A
D
F
L
P
I
A
L
G
-
R
A
T
G
C
S
G
--
N
S
L
------
D
N
S
L
R
I
T
G
-
A
A
-----
A
P
G
W
C
L
C
D
M
I
I
P
S
S
A
S
G
F
A
Q
G
Q
V
T
L
W
D
Q
S
G
R
L
L
A
T
G
A
Q
S
L
L
L
K
-------
5
PsiBlast_PDB
60.75
31%
-6
- C6 -
-
4R9Z
-
?
A:
[4-267]
------
S
L
G
D
V
L
A
T
L
E
L
E
R
V
G
Q
W
R
F
V
G
Q
Q
-
L
P
A
PA---
N
-
H
I
L
G
G
H
I
S
A
Q
A
L
L
A
A
S
R
T
A-
A
--
G
R
E
P
H
S
V
H
T
Y
F
L
R
P
G
D
S
R
Q
P
V
D
F
E
V
V
D
L
Q
E
G
R
T
F
S
A
R
R
V
T
A
R
Q
D
D
K
I
L
M
E
A
M
S
S
F
K
V----
Q
-
V
V
Y
Q
-
P
--
I
M
P
E
A
P
S
P
E
S
L
----------------------------
A
S
L
R
W
F
E
R
R
T
I
E
--
T
E
T
---
V
P
-
P
A
R
V
P
M
-----
W
W
R
P
D
G
R
V
P
---
D
D
P
V
L
T
A
S
L
V
A
Y
M
S
A
V
T
L
T
E
P
A
F
A
A
R
G
G
V
G
A
S
------
A
Q
R
D
H
S
V
W
F
H
G
R
A
V
-----
L
S
D
W
L
F
Y
D
R
S
S
P
S
S
A
G
S
L
A
L
A
S
G
T
M
F
N
R
T
G
E
L
V
C
T
V
K
Q
E
-----------
23
HHSearch
57.53
21%
-14
- C6 -
-
3CJY
7
?
A:
[5-258]
---------
A
F
P
-
A
L
V
R
Q
D
D
A
R
Y
A
I
T
V
G
P
D
L
A
V
G
P
PGH
A
-
Y
L
F
G
G
A
S
M
A
L
A
L
D
V
A
A
E
T
--
V
--
G
R
P
V
V
Q
G
S
L
Q
F
V
S
F
T
P
L
G
S
V
L
D
L
T
V
E
V
L
Q
S
G
R
T
L
A
Q
A
R
V
A
G
T
V
D
G
R
L
V
F
H
S
G
I
S
L
G
-
M
R
E
G
F
-
S
A
R
Q
W
A
--
L
A
P
P
V
P
Q
P
D
N
C
P
P
C
T
T
L
----
P
A
Q
D
---
D
---
N
A
---
R
Y
--
L
E
G
I
E
V
R
E
A
G
G
P
---------
E
V
P
S
G
R
T
R
L
--
W
L
R
R
K
D
-------
G
A
P
L
D
A
A
S
L
A
M
F
A
D
F
L
P
I
A
L
G
-
R
A
T
------
G
C
S
G--
N
S
L
D
N
S
L
R
I
T
G
-
A
A
-----
A
P
G
W
C
L
C
D
M
I
I
P
S
S
A
S
G
F
A
Q
G
Q
V
T
L
W
D
Q
S
G
R
L
L
A
T
G
A
Q
S
L
L
L
K
-------
7
PsiBlast_PDB
52.93
24%
-94
- C6 -
-
3BBJ
1
?
A:
[31-123]
------------------------------
L
I
G
-----
T
-
A
M
N
G
G
Y
L
M
T
V
L
Q
R
S
A
L
A
E
--
S
--
D
H
L
H
A
V
S
S
S
Y
H
F
H
R
P
A
S
S
G
P
A
E
I
E
T
R
V
L
K
R
G
R
T
V
T
T
V
Q
T
T
L
F
Q
E
G
R
T
I
L
T
G
T
L
A
T
A
-
T
L
D
P
-------
H
--
A
E
P
R
Y
A
A
P
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
51.32
18%
-20
- C6 -
-
3RQB
-
?
A:
[8-271]
---
V
T
H
A
F
D
D
A
T
-
A
L
S
-
F
D
G
R
Q
F
H
G
Q
V
K
A
E
Y
Y
N
-----
M
V
G
P
F
G
G
I
T
A
A
T
M
L
K
A
A
M
S
H
--
P
ER
L
G
Q
P
L
A
L
T
V
N
F
A
A
P
A
K
V
A
-
P
F
V
I
E
A
V
P
V
R
T
N
R
S
T
Q
H
F
T
L
T
M
M
Q
D
G
E
V
V
T
T
A
T
A
V
F
G
-
I
R
R
E
S
-
W
S
H
T
E
A
--
V
M
P
D
V
P
P
P
A
D
V
P
R
F
V
A
P
-----
A
P
----
L
--------
P
W
--
M
Q
W
Y
H
V
R
L
I
R
G
S
A
F
-----
D
-
E
V
Q
D
A
T
T
Y
Q
--
W
M
R
D
D
P
-------
P
R
P
L
D
H
A
A
L
A
A
L
C
D
T
F
V
P
R
V
Y
V
K
-
L
------
K
R
P
V
P
I
G
T
V
T
F
T
V
Y
F
L
A
D
P
E
T
I
F
R
Q
G
T
N
E
L
L
G
V
A
R
A
T
G
F
S
H
G
Y
F
D
Q
I
G
E
V
W
S
Q
D
G
D
L
L
A
T
T
T
Q
L
V
Y
M
K
A
P
V
----