@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQU6: (2017-11-29 )
MQSGAIRPIPNMLPRHLFNEEHEAFRETVRKFYEKEVVPNIEKYEKQQHVDRDLWNKAGALGLLCTTMPEQYGGSGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYINNFGNEEQKQKWLPKMATGETVTAIAMTEPGTGSDLQAVRTTAVLDGDEYVINGSKIFITNGYLCDMAIVVCKTGNSDKGSANLSLIIVEANRAGFTKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGMEGMGFIMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGAFQNTRFKLAELRTEIDFCRTYLDRCMELQLNEKLSVEAAAAAKYKISDMFSKVVDECLQLHGGYGYMIEYPIARAYIDHRANRIYAGTNEIMKELISRTL
Atome Classification :
(20 SA)
.........10........20........30........40.......-.50........60........70........80.........90....-....100...--....110.......120.......130.......140.......150...--....160.......170.......180...-...-.190.-......200.......210.......220.......230.......-240.......250.......260.......270.......280.......290.......300.......310-.....-..320-.-------------------......330.......340.......350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQSGAIRP
I
P
N
M
L
P
R
H
L
F
N
E
E
H
E
A
F
R
E
T
V
R
K
F
Y
E
K
E
VVP
N
I
E
K
Y
E
K
Q
Q
-HV
D
R
D
L
W
NKAGA
L
G
L
L
CTT
M
P
E
QYGG
S
G
V
D
R
L
-
Y
S
M
I
L
I
E
E
Q
AYAMDS-STGF
S
L
H
S
D
I
--
V
A
N
Y
I
N
NFG
N
E
E
Q
K
Q
KWLPKMATG
E
T
V
T
A
I
A
MTEPGTGS
D
L
Q
A
V
R
T
T
A
V
L--DGD
E
Y
V
ING
S
K
I
F
I
TNGY
L
C
D
M
A
I
V
V
C
KTG-NSD-KGSA
N
-
L
S
L
I
I
V
EANRAGFTKGKP
L
N
KIGMKG
Q
D
T
C
E
L
F
F
D
NVRV
P
K
E
NLLG-ME
G
M
G
F
I
M
L
M
K
E
L
A
W
E
R
M
L
V
A
I
I
CQAGA
E
A
A
F
A
H
T
V
Q
YTKD
R
K
AFGKPIGAFQNTR
F
K
L
A
E
L
R
T
E
I
D
F
C
R
T
Y
L
-
D
R
C
M
E
-
L
QLNE-K-------------------LS
V
E
AAAAAK
Y
K
I
S
D
M
F
S
K
V
V
D
E
C
L
Q
L
HGGY
G
Y
M
I
EY
P
I
A
R
A
Y
I
D
HRANRIYAG
T
N
E
I
M
K
E
L
I
S
RTL
124
HHSearch
93.18
49%
-60
- C2 -
-
2PG0
2
?
A:
[6-383]
-------------
T
A
R
Y
L
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
-
I
I
P
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
A
-
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
-
L
V
G
I
G
L
H
N
D
I
--
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
--
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
-
P
Q
A
K
P
P
H
R
G
-
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
-
D
R
V
I
E
-
E
H
M
A
G
-
K
-------------------
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
21
PsiBlast_CBE
92.76
49%
-61
- C2 -
-
2PG0
2
?
B:
[8-383]
--------------
R
Y
L
-
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
-
I
I
P
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
A
-
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
-
L
V
G
I
G
L
H
N
D
I
--
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
--
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
-
P
Q
A
-
K
P
P
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
-
D
R
V
I
E
-
E
H
M
A
G
-
K
-------------------
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
1
PsiBlast_PDB
92.49
49%
-60
- C2 -
-
2PG0
2
?
A:
[6-383]
------------
T
A
R
Y
L
-
R
E
E
H
H
M
F
R
A
A
F
R
K
F
L
E
K
E
A
Y
P
H
Y
N
D
W
E
K
R
G
-
I
I
P
R
S
F
W
A
K
M
G
E
N
G
F
L
C
P
W
V
D
E
K
Y
G
G
L
N
A
D
F
A
-
Y
S
V
V
I
N
E
E
L
E
K
V
G
S
S
-
L
V
G
I
G
L
H
N
D
I
--
V
T
P
Y
I
A
S
Y
G
T
E
E
Q
K
Q
K
W
L
P
K
C
V
T
G
E
L
I
T
A
I
A
M
T
E
P
G
A
G
S
D
L
A
N
I
S
T
T
A
V
K
--
D
G
D
Y
Y
I
V
N
G
Q
K
T
F
I
T
N
G
I
H
A
D
L
I
V
V
A
C
K
T
D
-
P
Q
A
-
K
P
P
H
R
G
I
S
L
L
V
V
E
R
D
T
P
G
F
T
R
G
R
K
L
E
K
V
G
L
H
A
Q
D
T
A
E
L
F
F
Q
D
A
K
V
P
A
Y
N
L
L
G
-
E
E
G
K
G
F
Y
Y
L
M
E
K
L
Q
Q
E
R
L
V
V
A
I
A
A
Q
T
A
A
E
V
M
F
S
L
T
K
Q
Y
V
K
Q
R
T
A
F
G
K
R
V
S
E
F
Q
T
V
Q
F
R
L
A
E
M
A
T
E
I
A
L
G
R
T
F
V
-
D
R
V
I
E
-
E
H
M
A
G
-
K
-------------------
Q
I
V
T
E
V
S
M
A
K
W
W
I
T
E
M
A
K
R
V
A
A
E
A
M
Q
L
H
G
G
Y
G
Y
M
E
E
Y
E
I
A
R
R
Y
R
D
I
P
V
S
A
I
Y
A
G
T
N
E
M
M
K
T
I
I
A
R
Q
L
43
PsiBlast_CBE
89.21
33%
-80
- C2 -
-
1RX0
9
ACAD8_HUMAN
C:
[15-390]
-------------
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
-
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
L
-
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
-
T
T
A
Y
I
S
I
H
N
M
--
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
--
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
-
G
---
P
G
P
K
G
-
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
-
L
Q
E
E
R
-
K
-------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
42
PsiBlast_CBE
88.85
33%
-81
- C2 -
-
1RX0
12
ACAD8_HUMAN
D:
[15-390]
-------------
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
-
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
L
-
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
-
T
T
A
Y
I
S
I
H
N
M
--
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
--
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
-
G
---
P
G
P
K
G
-
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
-
L
Q
E
E
R
-
K
-------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
44
PsiBlast_CBE
87.04
33%
-81
- C2 -
-
1RX0
10
ACAD8_HUMAN
B:
[15-390]
-------------
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
-
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
L
-
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
-
T
T
A
Y
I
S
I
H
N
M
--
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
--
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
-
G
---
P
G
P
K
G
-
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
-
L
Q
E
E
R
-
K
-------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
49
PsiBlast_CBE
86.79
34%
-81
- C2 -
-
1UKW
2
?
B:
[5-376]
-----------------
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
-
E
V
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
K
M
L
-
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
-
I
Y
T
I
P
M
A
S
D
L
--
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
--
Q
G
D
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
-
V
V
V
F
A
T
V
-
N
P
E
-
L
R
H
K
G
-
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
-
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
-
Y
Y
A
A
W
-
L
A
D
Q
G
-
L
-------------------
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
13
PsiBlast_PDB
86.62
34%
-81
- C2 -
-
1UKW
2
?
A:
[5-376]
-----------------
L
T
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
E
-
E
V
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
K
M
L
-
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
-
I
Y
T
I
P
M
A
S
D
L
--
G
I
T
P
V
L
L
A
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
I
R
--
Q
G
D
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
-
V
V
V
F
A
T
V
-
N
P
E
-
L
R
H
K
G
-
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
-
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
-
Y
Y
A
A
W
-
L
A
D
Q
G
-
L
-------------------
P
H
A
H
A
S
A
I
A
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
10
PsiBlast_PDB
86.39
33%
-80
- C2 -
-
1RX0
8
ACAD8_HUMAN
A:
[15-390]
-------------
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
-
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
L
-
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
-
T
T
A
Y
I
S
I
H
N
M
--
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
--
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
-
G
---
P
G
P
K
G
-
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
-
L
Q
E
E
R
-
K
-------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
18
PsiBlast_PDB
83.16
33%
-67
- C2 -
-
3PFD
1
?
A:
[22-391]
--------------------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
A
-
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
D
S
V
-
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
I
P
A
V
N
K
L
--
G
T
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
V
A
--
D
G
D
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
--
D
P
D
-
K
G
A
N
G
-
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
-
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
-
A
E
R
G
------------------------
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
116
HHSearch
81.55
33%
-41
- C2 -
-
1RX0
9
ACAD8_HUMAN
C:
[11-390]
---------
S
C
I
D
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
-
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
L
-
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
T
T
A
Y
I
S
I
H
-
N
M
--
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
--
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
-
G
P
---
G
P
K
G
-
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
-
R
N
A
A
V
-
A
L
Q
E
E
R
K
-------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
22
PsiBlast_CBE
81.07
40%
-19
- C2 -
-
4L1F
4
?
B:
[5-377]
-----------------
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
-
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
--
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
-
G
T
G
I
T
L
S
A
N
V
SL
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
-
K
S
--
Q
G
V
H
G
-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
-
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
-
Y
H
A
A
M
-
L
K
N
E
G
-
K
-------------------
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
48
PsiBlast_CBE
80.98
36%
-48
- C2 -
-
4IV6
2
?
B:
[7-380]
-----------------
L
T
A
E
E
E
T
I
V
K
T
V
H
D
F
V
E
K
Q
V
K
P
V
V
R
E
L
E
H
A
N
-
T
Y
P
E
E
L
I
E
T
M
K
E
I
G
I
F
G
L
A
I
P
E
P
Y
G
F
G
A
V
S
M
P
-
C
Y
V
Q
V
A
E
E
L
A
R
G
W
M
S
-
L
A
G
A
M
G
G
H
T
V
--
V
S
K
L
L
L
L
F
G
T
E
E
Q
K
Q
K
Y
L
P
R
M
A
T
G
E
L
R
A
T
M
A
L
T
E
P
G
G
G
S
D
L
Q
A
M
R
T
V
A
R
R
--
D
G
D
D
Y
V
I
N
G
S
K
T
W
I
S
N
A
R
R
S
D
L
V
A
L
M
C
K
T
D
P
D
A
Q
-
P
A
H
K
G
-
V
S
I
L
L
V
E
-
K
V
P
G
F
D
V
S
R
D
L
P
K
L
G
Y
K
G
V
E
S
C
E
L
N
F
T
D
A
R
V
P
V
S
S
L
L
G
D
D
E
G
R
G
F
A
Q
M
M
K
G
L
E
V
G
R
L
Q
V
A
A
R
A
T
G
V
A
R
A
A
F
E
D
A
L
R
Y
S
Q
E
R
E
S
F
G
K
P
I
W
Q
H
Q
S
V
G
N
M
L
A
D
M
G
T
K
L
Y
A
A
R
S
L
L
-
L
S
A
A
E
K
F
D
A
G
Q
-
R
-------------------
C
D
M
E
-
A
G
M
A
K
L
F
A
S
E
T
A
M
Q
I
A
L
D
A
V
R
V
H
G
G
Y
G
Y
S
T
E
Y
D
V
E
R
Y
F
R
D
A
P
L
M
I
V
G
E
G
T
N
E
I
Q
R
N
V
I
A
K
Q
L
129
HHSearch
80.83
39%
-38
- C2 -
-
4L1F
5
?
A:
[2-377]
--------------
D
F
N
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
-
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
-
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
T
G
I
T
L
S
A
N
V
S
L
--
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
-
K
S
Q
--
G
V
H
G
-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
-
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
-
Y
H
A
A
M
-
L
K
N
E
G
-
K
-------------------
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
24
PsiBlast_CBE
79.84
37%
-39
- C2 -
-
4U83
1
?
C:
[9-382]
----------------
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
-
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
M
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
-
S
T
I
V
S
V
H
S
S
V
--
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
R
L
--
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
--
D
P
A
-
A
G
K
K
G
-
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
-
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
-
L
H
A
A
A
-
L
R
E
A
G
-
K
-------------------
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
3
PsiBlast_PDB
79.63
37%
-40
- C2 -
-
4U83
1
?
A:
[9-382]
----------------
L
L
T
D
T
Q
E
Q
I
R
E
A
A
R
D
F
A
Q
E
R
L
A
P
G
A
A
A
R
D
R
E
H
-
A
F
P
R
A
E
L
T
E
M
G
A
L
G
F
L
G
M
L
A
P
E
E
W
G
G
S
D
L
D
M
V
A
Y
A
L
A
L
E
E
I
A
A
G
D
G
A
C
-
S
T
I
V
S
V
H
S
S
V
--
G
C
M
P
I
L
R
F
G
T
E
D
Q
K
R
R
F
L
P
K
M
A
C
G
E
W
I
G
G
F
A
L
T
E
P
--------
L
K
T
R
A
R
L
--
D
G
D
H
Y
V
I
D
G
S
K
Q
F
I
T
S
G
K
N
G
N
V
V
I
V
F
A
V
T
--
D
P
A
-
A
G
K
K
G
-
I
S
A
F
I
V
P
T
D
T
P
G
Y
E
V
M
S
V
E
H
K
L
G
Q
H
S
S
D
T
C
A
L
G
F
T
N
M
R
V
P
V
E
N
R
L
G
-
A
E
G
E
G
Y
K
I
A
L
A
N
L
E
G
G
R
I
G
I
A
A
Q
A
V
G
M
A
R
A
A
F
E
A
A
R
D
Y
A
R
E
R
I
T
F
G
K
P
I
I
E
H
Q
A
V
A
F
R
L
A
D
M
A
T
R
I
E
T
A
R
Q
M
V
-
L
H
A
A
A
-
L
R
E
A
G
-
K
-------------------
P
C
L
T
E
A
S
M
A
K
L
V
A
S
E
M
A
E
Q
V
C
S
A
A
I
Q
I
H
G
G
Y
G
Y
L
A
D
Y
P
V
E
R
I
Y
R
D
V
R
V
C
Q
I
Y
E
G
T
S
D
V
Q
R
L
V
I
A
R
G
L
55
PsiBlast_CBE
79.44
33%
-65
- C2 -
-
3PFD
1
?
B:
[22-391]
--------------------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
A
-
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
D
S
V
-
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
I
P
A
V
N
K
L
--
G
T
M
G
L
I
L
R
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
V
A
--
D
G
D
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
--
D
P
D
-
K
G
A
N
G
-
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
-
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
-
A
E
R
G
------------------------
G
F
I
S
A
A
S
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
2
PsiBlast_PDB
79.23
40%
-17
- C2 -
-
4L1F
5
?
A:
[5-377]
-----------------
L
T
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
H
-
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
D
V
L
--
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
-
G
T
G
I
T
L
S
A
N
V
SL
C
A
T
P
I
Y
M
F
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
--
K
G
D
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
-
K
S
--
Q
G
V
H
G
-
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
-
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
-
Y
H
A
A
M
-
L
K
N
E
G
-
K
-------------------
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
117
HHSearch
79.16
33%
-41
- C2 -
-
1RX0
8
ACAD8_HUMAN
A:
[10-390]
--------
T
S
C
I
D
P
S
M
G
L
N
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
E
-
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
S
R
L
-
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
T
T
A
Y
I
S
I
H
-
N
M
--
C
A
W
M
I
D
S
F
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
K
K
--
Q
G
D
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
-
G
P
---
G
P
K
G
-
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
-
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
-
R
N
A
A
V
-
A
L
Q
E
E
R
K
-------------------
D
A
V
A
L
C
S
M
A
K
L
F
A
T
D
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C
F
A
I
C
N
Q
A
L
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M
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Y
G
Y
L
K
D
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V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
126
HHSearch
78.95
36%
-24
- C2 -
-
3OWA
5
?
D:
[26-426]
----------
Q
V
F
T
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E
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--
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-
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------
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-
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-