@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQX9: (2017-11-29 )
MNYRHHFHAGNFADVMKHVLLLQLLNRLNAKDKPYRYIDTHGGAGKYDLSQAPAQKSGEFLTGIHRLVQLSGMEKRQAPEAIQQYLKLVEELRAQEGKGSYPGSPWFALQGMREIDKATIFEMQRDVFQQLRHNIHDKRAGLHERDAYEGLLAVIPPKEKRGLVMIDPPYELERKDFPQLVELLQSAYKKWPTGVFAVWYPIKDRAMIERFEKKMFKTGIRRQLICEICVWPDDTPVGLNGCGLLVINPPWQFSEQADQALQWLFPHLRMQETGGHAAVRWLVGE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110..-.--.---------------------------------------....120.......130....-.----.--.140.......150--.......-.160----........170...--------.---------.---------...180.......190.......200.......210.....---..220.......230.......240.......250-.......260.......270..-.....280...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MN
Y
R
H
HFHAG
N
F
A
D
V
M
K
H
V
L
L
L
Q
L
L
N
RLNAKDK
P
Y
R
Y
IDTHGGAGKYDLSQAPAQKSG
E
F
L
T
G
I
H
R
L
V
Q
LSGMEKRQ
A
P
E
A
I
Q
Q
Y
L
K
L
V
E
E
L
R
AQEGKGSYPGS
P
W
F
A
L
Q
-
G
M
R
-
E
--
I
---------------------------------------
D
K
A
T
I
F
E
M
Q
R
D
V
F
Q
Q
L
R
H
N
I
H
-
D
----
K
--RAGLH
E
R
D
A
YE
G
L
---
L
A
VIPPK-EKR-----
G
L
V
M
IDPPY-EL
E
R
--------
K
---------
D
---------
F
P
Q
L
V
E
L
L
Q
S
A
Y
K
KWPT
G
V
F
A
V
W
YPIK
D
R
A
M
I
E
R
F
E
K
K
M
F
K
---
T
G
I
R
R
Q
L
I
C
E
I
C
VWPDDTPVGLNG
C
G
L
L
V
INPPWQ-
F
S
E
Q
A
D
Q
A
L
Q
W
L
F
P
H
LRMQETG-
G
H
A
A
V
R
W
LVGE
14
HHSearch
95.91
39%
-63
- C5 -
-
4BLV
15
RLMJ_ECOLI
A:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
H
A
E
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
-----
D
L
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
-
K
D---
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
K
---------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
H
S
K
L
V
P
A
G
T
G
-
H
-
A
T
V
S
W
I
V
P
E
3
PsiBlast_PDB
95.46
38%
-64
- C5 -
-
4BLW
15
RLMJ_ECOLI
A:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
H
A
E
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
D
L
-----
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
K
D
----
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
-
K
--------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
--
H
S
K
L
V
P
A
G
T
G
H
A
T
V
S
W
I
V
P
E
2
PsiBlast_PDB
95.34
38%
-60
- C5 -
-
4BLV
15
RLMJ_ECOLI
A:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
H
A
E
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
D
L
-----
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
K
D
----
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
-
K
--------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
--
H
S
K
L
V
P
A
G
T
G
H
A
T
V
S
W
I
V
P
E
11
PsiBlast_CBE
95.16
38%
-63
- C5 -
-
4BLW
8
RLMJ_ECOLI
B:
[2-279]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
H
A
E
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
D
L
-----
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
K
D
----
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
-
K
--------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
--
H
S
K
L
V
P
A
G
T
G
H
A
T
V
S
W
I
V
P
-
15
HHSearch
93.73
39%
-63
* C5 *
-
4BLU
9
RLMJ_ECOLI
A:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
H
A
E
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
-----
D
L
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
-
K
D---
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
K
---------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
H
S
K
L
V
P
A
G
T
G
-
H
-
A
T
V
S
W
I
V
P
E
12
PsiBlast_CBE
93.70
38%
-57
- C5 -
-
4BLV
7
RLMJ_ECOLI
B:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
---
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
D
L
-----
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
K
D
----
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
-
K
--------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
--
H
S
K
L
V
P
A
G
T
G
H
A
T
V
S
W
I
V
P
E
13
PsiBlast_CBE
93.00
38%
-60
- C5 -
-
4BLU
14
RLMJ_ECOLI
B:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
---
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
D
L
-----
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
K
D
----
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
-
K
--------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
--
H
S
K
L
V
P
A
G
T
G
H
A
T
V
S
W
I
V
P
E
1
PsiBlast_PDB
92.80
38%
-59
- C5 -
-
4BLU
9
RLMJ_ECOLI
A:
[2-280]
L
S
Y
R
H
S
F
H
A
G
N
H
A
D
V
L
K
H
T
V
Q
S
L
I
I
E
S
L
K
E
K
D
K
P
F
L
Y
L
D
T
H
A
G
A
G
R
Y
Q
L
G
S
E
H
A
E
R
T
G
E
Y
L
E
G
I
A
R
I
W
Q
Q
D
D
L
-----
P
A
E
L
E
A
Y
I
N
V
V
K
H
F
N
R
S
G
Q
L
R
Y
Y
P
G
S
P
L
I
A
R
L
-
L
L
R
-
E
--
Q
---------------------------------------
D
S
L
Q
L
T
E
L
H
P
S
D
Y
P
L
L
R
S
E
F
Q
K
D
----
S
--
R
A
R
V
E
K
A
D
G
F
Q
Q
L
---
K
A
K
L
P
P
V
-
S
R
R
-----
G
L
I
L
I
D
P
P
Y
-
E
M
-
K
--------
T
---------
D
---------
Y
Q
A
V
V
S
G
I
A
E
G
Y
K
R
F
A
T
G
I
Y
A
L
W
Y
P
V
V
L
R
Q
Q
I
K
R
M
I
H
D
L
E
A
---
T
G
I
R
K
I
L
Q
I
E
L
A
V
L
P
D
S
D
R
R
G
M
T
A
S
G
M
I
V
I
N
P
P
W
K
-
L
E
Q
Q
M
N
N
V
L
P
W
L
--
H
S
K
L
V
P
A
G
T
G
H
A
T
V
S
W
I
V
P
E
37
Fugue
91.73
33%
-70
- C5 -
-
2OO3
-
?
A:
[10-280]
-------
H
A
G
N
F
A
D
V
I
K
H
I
T
L
T
R
L
L
A
Y
L
T
H
K
D
K
P
L
F
Y
L
E
T
H
S
G
R
G
I
Y
D
L
K
D
----
K
T
E
E
Y
K
E
G
I
N
P
V
W
L
----
D
R
E
N
L
P
S
L
F
L
E
Y
I
S
V
I
K
Q
I
N
L
N
S
T
L
S
Y
Y
P
G
S
P
Y
F
A
I
N
-
Q
L
R
-
S
--
Q
---------------------------------------
D
R
L
Y
L
C
E
L
H
P
T
E
Y
N
F
L
L
K
L
P
H
F
N
----
K
--
K
V
Y
V
N
H
T
D
G
V
S
K
L
---
N
A
L
L
P
P
P
-
E
K
R
-----
G
L
I
F
I
D
P
S
Y
-
E
-
R
K
--------
E
---------
E
---------
Y
K
E
I
P
Y
A
I
K
N
A
Y
S
K
F
S
T
G
L
Y
C
V
W
Y
P
V
V
N
K
A
W
T
E
Q
F
L
R
K
M
R
E
---
I
S
S
K
-
S
V
R
I
E
L
H
L
N
P
L
I
N
E
-
G
M
T
G
C
G
L
W
I
I
N
P
P
Y
T
-
F
P
S
E
I
K
L
V
L
E
T
L
T
T
Y
F
N
P
G
S
S
S
-
Y
M
I
E
S
G
S
K
L
C
-
16
HHSearch
91.62
34%
-73
- C5 -
-
2OO3
-
?
A:
[10-269]
-------
H
A
G
N
F
A
D
V
I
K
H
I
T
L
T
R
L
L
A
Y
L
T
H
K
D
K
P
L
F
Y
L
E
T
H
S
G
R
G
I
Y
D
L
K
D
K
----
T
E
E
Y
K
E
G
I
N
P
V
W
L
D
R
----
E
N
L
P
S
L
F
L
E
Y
I
S
V
I
K
Q
I
N
L
N
S
T
L
S
Y
Y
P
G
S
P
Y
F
A
I
N
-
Q
L
R
-
S
--
Q
---------------------------------------
D
R
L
Y
L
C
E
L
H
P
T
E
Y
N
F
L
L
K
L
P
H
-
F
N---
K
--
K
V
Y
V
N
H
T
D
G
V
S
K
L
---
N
A
L
L
P
P
P
-
E
K
R
-----
G
L
I
F
I
D
P
S
Y
-
E
R
K
---------
E
---------
E
---------
Y
K
E
I
P
Y
A
I
K
N
A
Y
S
K
F
S
T
G
L
Y
C
V
W
Y
P
V
V
N
K
A
W
T
E
Q
F
L
R
K
M
R
E
---
I
S
-
S
K
S
V
R
I
E
L
H
L
N
P
L
-
I
N
E
G
M
T
G
C
G
L
W
I
I
N
P
P
Y
T
-
F
P
S
E
I
K
L
V
L
E
T
L
T
T
Y
F
N
P
G
S
S
-------------
4
PsiBlast_PDB
89.17
34%
-66
- C5 -
-
2OO3
-
?
A:
[10-260]
-------
H
A
G
N
F
A
D
V
I
K
H
I
T
L
T
R
L
L
A
Y
L
T
H
K
D
K
P
L
F
Y
L
E
T
H
S
G
R
G
I
Y
D
L
K
D
K
----
T
E
E
Y
K
E
G
I
N
P
V
----
W
L
D
R
E
N
L
P
S
L
F
L
E
Y
I
S
V
I
K
Q
I
N
L
N
S
T
L
S
Y
Y
P
G
S
P
Y
F
A
I
N
-
Q
L
R
-
S
--
Q
---------------------------------------
D
R
L
Y
L
C
E
L
H
P
T
E
Y
N
F
L
L
K
L
P
H
F
N
----
K
--
K
V
Y
V
N
H
T
D
G
V
S
K
L
---
N
A
L
L
P
P
P
-
E
K
R
-----
G
L
I
F
I
D
P
S
Y
-
E
-
R
K
--------
E
---------
E
---------
Y
K
E
I
P
Y
A
I
K
N
A
Y
S
K
F
S
T
G
L
Y
C
V
W
Y
P
V
V
N
K
A
W
T
E
Q
F
L
R
K
M
R
E
---
I
S
S
K
S
V
R
I
-
E
L
H
L
N
P
L
I
N
E
-
G
M
T
G
C
G
L
W
I
I
N
P
P
Y
T
-
F
P
S
E
I
K
L
V
L
E
T
L
----------------------
29
HHSearch
42.99
15%
-24
- C5 -
-
3K0B
-
?
A:
[203-356]
----------------------------------------------------------------------------------------------
R
P
F
Y
D
P
V
C
G
S
G
T
I
P
I
E
-
A
A
L
I
G
--
Q
NIAPGFNREFVSETWDWMP
K
Q
V
W
A
D
A
R
Q
E
A
E
D
L
ANYDQP
L
N
I
I
G
G
D
I
D
A
R
L
I
E
I
A
K
Q
N
A
V
-
E
A
GLG
D
--
L
I
T
F
R
Q
L
Q
V
A
D
F
Q
---
T
-----
E
-
D
E
Y
-----
G
V
V
V
A
N
P
P
Y
-
G
E
R
---------
L
---------
E
D
E
E
A
-----
V
R
Q
L
Y
R
E
M
G
I
V
Y
K
R
M
P
T
W
S
V
Y
V
L
T
S
Y
----------------------------------------------------------------------------------------
17
HHSearch
41.71
15%
-24
- C5 -
-
1WXX
-
?
C:
[211-329]
----------------------------------------------------------------------------------------------
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
-
L
A
L
-
G
--
F
---------------------------------------
R
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
-
L
NGL-
G
--
N
V
R
V
L
E
A
N
A
F
D
L
L
---
R
R
L
E
K
E
G
-
E
R
F
-----
D
L
V
V
L
D
P
P
A
-
F
A
K
---------
G
---------
K
KDVERAYRA
Y
K
E
V
N
L
R
A
I
K
L
L
K
--
E
G
G
I
L
A
T
A
S
C
S
H
H
--------------------------------------------------------------------------------------
43
Fugue
38.09
13%
-53
- C3 -
-
3F4M
-
TP8L2_HUMAN
A:
[8-161]
----------------------------------------------------
I
D
E
T
S
S
E
V
L
D
E
L
Y
R
V
S
K
E
Y
T
H
S
R
P
Q
A
Q
R
V
I
K
D
L
I
K
V
A
I
K
V
A
V
L
H
R
N
G
S
F
G
P
S
E
L
A
L
A
T
-
R
F
R
-
Q
--
K
---------------------------------------
L
R
Q
--
G
A
M
T
A
L
S
F
G
E
V
D
F
T
F
E
-
A
----
A
--
V
L
A
G
L
L
T
E
C
R
D
V
L
---
L
E
L
V
E
H
H
L
T
P
K
-----
S
H
G
R
I
R
H
V
F
-
D
H
F
---------
S
---------
D
---------
P
G
L
L
T
A
L
Y
G
P
D
F
T
Q
H
L
G
K
I
C
D
G
L
R
K
L
L
D
E
G
K
L
----------------------------------------------------------------------------------
19
HHSearch
36.46
11%
-18
- C5 -
-
3VSE
1
?
B:
[216-335]
----------------------------------------------------------------------------------------------
R
H
V
L
N
L
F
S
Y
T
G
A
F
S
V
I
-
A
A
S
-
E
--
A
---------------------------------------
S
S
T
T
S
V
D
L
A
N
R
S
R
S
L
T
E
E
N
F
G
-
L
N
AI-
D
PK
S
Q
Y
I
Y
V
M
D
T
F
D
F
Y
---
K
Y
A
A
R
H
G
-
H
S
Y
-----
D
T
I
V
I
D
P
P
S
-
F
A
R
---------
N
KK
R
T
F
S
VQK
D
---------
Y
D
K
L
I
N
G
A
L
N
I
L
S
--
S
E
G
T
L
L
L
C
T
N
A
S
---------------------------------------------------------------------------------------
40
Fugue
36.28
10%
2
- C5 -
-
4ZSF
2
?
A:
[1-272]
---------
M
N
F
F
E
Y
C
I
S
T
Y
A
K
I
F
E
E
T
M
N
A
V
G
D
E
R
V
S
Q
K
K
A
I
R
D
T
M
I
S
A
M
R
E
F
P
N
V
E
A
A
E
I
W
K
A
V
Y
S
A
H
M
D
R
K
S
G
I
A
D
P
D
I
I
Q
K
V
I
S
A
E
N
S
W
K
K
S
S
G
H
A
F
E
E
M
I
K
L
L
G
N
S
-
S
L
E
-
E
YG
M
---------------------------------------
R
I
L
L
Q
K
D
L
N
M
M
I
E
N
Q
E
I
A
N
E
P
-
R
----
D
--
I
N
W
L
K
E
Q
I
S
S
N
V
F
---
D
L
Y
I
T
V
R
-
N
N
D
K
E
Y
V
F
G
C
I
Q
S
K
T
S
I
R
D
R
V
T
--------
R
---------
D
---------
R
E
P
S
M
K
A
M
E
A
-------
F
F
W
S
V
A
I
C
L
D
G
D
F
L
K
M
P
K
F
I
A
M
V
N
GGT
S
N
Y
R
L
N
G
W
H
G
M
Y
V
F
W
D
K
P
T
I
D
----
R
I
Y
P
I
D
I
N
L
E
L
F
V
Q
H
A
R
E
A
A
E
D
W
L
H
R
R
Q
W
F
N
Y
E
-
W
K
A
G
Q
K
-----
18
HHSearch
35.66
18%
11
- C5 -
-
4DMG
-
?
A:
[216-328]
----------------------------------------------------------------------------------------------
E
R
V
L
D
V
Y
S
Y
V
G
G
F
A
L
R
-
A
A
R
K
G
--
A
----------------------------------------
Y
A
L
A
V
D
K
D
L
E
A
L
G
V
L
D
Q
A
A
L
-
R
L
G--
L
--
R
V
D
I
R
H
G
E
A
L
P
T
L
---
R
G
L
---
E
-
G
P
F
-----
H
H
V
L
L
D
P
P
T
-
L
V
K
R
PEE
L
P
A
M
K
R
---------
H
---------
L
V
D
L
V
R
E
A
L
R
L
L
A
--
E
E
G
F
L
W
L
S
S
C
S
----------------------------------------------------------------------------------------
30
HHSearch
35.08
12%
-26
- C5 -
-
1UWV
-
RLMD_ECOLI
A:
[288-389]
----------------------------------------------------------------------------------------------
D
R
V
L
D
L
F
C
G
M
G
N
F
T
L
P
-
L
A
T
-
Q
--
A
---------------------------------------
A
S
V
V
G
V
E
G
V
P
A
L
V
E
K
G
Q
Q
N
A
R
-
L
N
GL-
Q
--
N
V
T
F
Y
H
E
N
L
E
E
D
V
---
T
K
Q
P
W
A
K
-
N
G
F
-----
D
K
V
L
L
D
P
A
R
-
A
G
A
---------
A
---------------------
G
V
M
Q
Q
I
I
K
-
L
E
--
P
I
R
I
V
Y
V
S
C
------------------------------------------------------------------------------------------
38
Fugue
35.07
13%
-17
- C5 -
-
3KJH
-
?
A:
[1-254]
---
M
K
L
A
V
A
G
K
-
G
G
V
G
K
T
T
V
A
A
G
L
I
K
I
M
A
S
D
Y
D
K
I
Y
A
V
D
G
D
P
D
S
---
C
L
G
Q
T
L
-
G
L
S
I
E
E
A
Y
A
I
T
P
L
I
E
M
K
D
E
I
R
E
K
T
G
D
G
G
L
L
I
L
N
P
K
V
D
G
D
L
D
K
-
Y
G
R
Y
I
D
D
K
I
F
L
I
R
M
G
E
I
-
K
--
K
---------------------------------------
G
G
S
Q
C
Y
C
R
E
N
S
F
L
G
S
V
V
S
A
L
F
-
L
----
D
--
K
K
E
A
V
V
M
D
M
G
A
G
I
EHL
T
R
G
T
A
K
A
-
V
D
M
-----
M
I
A
V
I
E
P
-----
N
L
--------
N
---------
S
---------
I
K
T
G
L
N
I
E
K
L
A
G
D
L
G
I
K
K
V
R
Y
V
I
N
K
V
R
N
I
K
E
E
K
L
I
K
K
H
L
P
-------
E
D
K
I
L
G
I
I
P
Y
N
E
L
F
I
E
L
S
L
K
G
------
E
E
I
W
Q
-
S
T
N
P
A
F
V
N
L
H
D
I
Y
Q
K
L
R
L
E
V
G
-------------
25
HHSearch
34.69
14%
32
- C5 -
-
2AS0
-
?
A:
[219-338]
----------------------------------------------------------------------------------------------
D
R
V
L
D
V
F
T
Y
T
G
G
F
A
I
H
-
A
A
I
A
G
--
A
---------------------------------------
D
E
V
I
G
I
D
K
S
P
R
A
I
E
T
A
K
E
N
A
K
-
L
N
GVE
D
--
R
M
K
F
I
V
G
S
A
F
E
E
M
---
E
K
L
Q
K
K
G
-
E
K
F
-----
D
I
V
V
L
D
P
P
A
-
F
V
Q
---------
H
---------
E
KD
L
K
A
G
L
R
A
Y
F
N
V
N
F
A
G
L
N
L
V
K
--
D
G
G
I
L
V
T
C
S
C
S
Q
---------------------------------------------------------------------------------------