@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR18: (2017-11-30 )
MAEIDMNTMDTFHQMDKSHQGYITEFNDKSEFEQRINTAWRRAEPEAVEELLQAAAVSDDLDHKIYDLAFNLAHNLRERKTSSGKAGIVQGLLQEFSLSSQEGVALMCLAEALLRIPDTATRDLLIRDKINQGNWKEHVGQSSLMFVNAAAWGLMLTGKLMETPKQTSLSSVLTGLLARSGRGIIRKAVDVAMRMMGEQFVTGETIEEAVDHAKVLEDKGFRYSYDMLGEAALTDHDAERYFNDYTQAIHAIGKASNGKGVYDGPGISIKLSALHPRYQRAQIERVHKELYGKVFELARLAKQYNIGLNIDAEESERLEISLELLERLCFEPELANWKGIGFVIQAYQKRCFFVVDYIIDLAKRSQKRLMIRLVKGAYWDSEIKKAQIEGMDDYPVFTRKVHTDLSYIACAKKLLAAPEFIYPQFATHNAQTLATIYHLADPSKYYAGQYEFQCLHGMGEPLYEQVVGPRQQNKLGVPCRIYAPVGNHETLLAYLVRRLLENGANTSFVNRIADKTLKVEDLIQSPIYDIRNAAKLEGSVGLKHPSIPLPLDMYGTLRKNSKGYDLANDTPLAALDSTAQELRNRIWQSHPLLANTDSLEQGHSVAITNPAQNDEIVGYVQEADLKHVEIALTAAEQTQSEWSNTPKDQCAQYLKRAADLMESRIQELMVLLCRESGKTYANAIAEVREAVDFLRYYATQVENLPANTVIQPLGTVLCISPWNFPLAIFSGQIAAALVSGNCVIAKPAEQTPLIAAQAVQILWEAGIPHGAVQLLPGRGETVGAQLSQDSRIDGIMFTGSTEVAKILQKTVAKRLSENGQSIPLIAETGGQNAMIVDSSALTEQVVLDVVSSAFDSAGQRCSALRILCVQEDSAATVIKMLKGAMQQLIVGNPAILKTDIGPVIDDEAKQTIDQHIQKMKSKGYPVHQLMFGATSQTELDKGTFVVPTAIELPNLDDLQREVFGPVLHIITYKYGELEQLISRINAKGYGLTMGLHTRIDETIQTVIQHAEVGNLYINRNIVGAVVGVQPFGGEGLSGTGPKAGGPLYMYRLMQHCSNKVLATPFAVKNEQTIFEGFNREVYQSLQNWAKQHLPQANREIEPFGVGKFYELQGPTGESNQYIILPRHRVLSIADTEQDQLHQLLAIFAVGSQAAVMQNSPLLAKHKQTLPKDVLDAITTIKNITTDDFDAVLHHGNRKEIFSLQQEIASRSGAIVGITHVEPNESIPLERLVIERAISVNTAAAGGNASLMTMSE
Atome Classification :
(41 SA)
.........10........20....---....30........40........50........60........70........80........90........100.-......110.......120.......130.......140.......150.......160--........170.......180.......190.......200.......210.......220.......230.......240.......250.......--------------260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550...-....560.......570.......580..-.-....590.......600.......610.......620.......630......---.640.......650.......660.......670.......680.-......690......--------.700..-------------.-------------.-------------...-----------710---------..-------------.......720.......730.......740.......750.......760.......770.......780.......790.......800..-.....810.......820....--...830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950...--....---.960--.........970.......980.......990......-.1000......1010......1020......-1030......1040......1050......1060......1070...---..-.1080.....-----.1090......1100......1110......1120......1130......1140......1150......1160......1170......1180...-.-..1190......1200......1210......1220.------.....1230......1240......1250..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAEID
M
N
T
M
D
T
F
H
Q
MDKSHQG
Y
I
TE---FN
D
K
S
E
F
E
Q
R
I
N
T
A
WRRA
E
P
E
A
V
E
E
L
L
Q
A
AAVSDDLD
H
K
I
Y
D
L
A
F
N
L
A
H
N
L
R
E
RKTSSG
K
A
G
I
V
Q
G
L
L
Q
EFSLSSQEG-
V
A
L
M
C
L
A
E
A
L
L
RIPDTATR
D
L
L
I
R
DKINQ
G
N
W
K
E
HVGQS
S
L
M
F
V
NAAA
W
G
L
M
L
T
G
K
L
M---ETPKQ
T
S
L
S
S
V
L
T
G
L
L
A
RSG
R
G
I
I
R
K
A
V
D
V
A
M
R
M
MGEQFVT
G
E
T
I
E
E
A
V
D
H
A
K
V
L
EDKG
F
R
Y
S
Y
D
MLGEAALT
D
H
D
A
E
R
Y
F
N
D
Y
T
Q
A
I
H
A
I
GKASNGK--------------GVYDGPG
I
S
I
K
L
SALHP
R
Y
Q
R
A
Q
I
E
R
V
H
K
E
L
Y
G
K
V
F
E
L
A
R
L
A
K
Q
YNI
G
L
N
IDAEES
E
R
L
E
I
S
L
E
L
L
E
R
LCFEPELANWK
G
I
G
F
V
I
Q
A
Y
Q
K
R
C
F
F
V
V
D
Y
I
I
D
L
A
K
R
S
Q
K
R
L
M
I
R
L
VKGAYW
D
S
E
I
K
K
A
QIEGMDDYP
V
F
T
R
K
VHTD
L
S
Y
I
A
C
A
K
K
L
LAAPEFIYPQFATHN
A
Q
T
L
A
T
I
YHLADPSKYYAG
Q
Y
E
F
Q
C
L
HGMG
E
P
L
Y
E
Q
VVGPRQQNKLGV
P
C
R
I
Y
A
PVG
N
H
E
T
L
L
A
Y
L
V
R
R
L
L
ENGA
N
T
S
F
V
N
R
I
A
DKT
L
K
V
E
D
L
I
QS
P
I
Y
D
I
R
N
A
A
KLEGSVGLKHPSIPL
P
L
D
M
Y
G
-
T
LRKNSKGYDLANDTP
L
A
A
L
D
S
T
A
Q
E
L
R
N
-
R
-
I
W
QSHPLLANTDSLEQGH
S
V
A
ITNPAQNDE
I
V
G
Y
V
Q
EADL
K
H
V
E
I
A
L
T
A
A
E
Q
T
---
Q
S
E
WSNT
P
K
D
Q
C
A
Q
Y
L
K
R
A
A
D
L
M
E
S
R
I
Q
E
L
M
V
L
L
C
RES
G
K
T
Y
A
N
A
-
I
A
E
V
R
E
A
V
D
F
L
R
Y
Y
A
--------
T
Q
V
ENL-------------P-------------A-------------NTV-----------I-----------QP-------------L
G
T
V
L
C
ISPWN
F
P
L
A
I
FSG
Q
I
A
A
A
LVSG
N
C
V
IAKPAEQTP
L
I
A
A
Q
A
V
Q
I
L
W
EAGIPH
G
A
V
Q
LLPGRGETVGAQLSQDSRI
D
G
I
M
FTG
S
T
E
V
A
-
K
I
L
Q
K
T
V
A
K
R
L
SENGQS
I
P
L
I
A
--ETGGQ
N
A
M
I
VD
S
S
A
L
T
E
Q
V
V
L
D
V
V
S
S
A
F
D
S
AGQR
C
S
A
L
R
I
L
C
VQED
S
A
A
T
V
I
K
M
L
K
G
A
M
Q
Q
L
IVGNP
A
I
L
KTDIGPVI
D
D
E
A
K
Q
T
I
D
Q
H
I
Q
K
M
K
SKGYP
V
H
Q
L
M
FGATSQTELDKG
T
F
V
V
P
TAI-ELP
N
--
L
D
D
L
---
Q
R
----
E
V
F
G
P
V
L
H
I
I
TYK
Y
G
E
L
E
Q
L
I
S
R
INAKGY
G
L
T
MG
L
H
T
R
-
I
D
E
T
I
Q
T
V
I
Q
HAEVG
N
L
Y
INRN
I
V
G
A
V
VGVQ-PFGGEGLSGTGPKAG
G
P
L
Y
M
Y
R
L
M
Q
H
CSNKVLAT
P
F
AVKN
E
Q
T
I
F
E
G---F
N
-
R
E
V
Y
Q
S
L
Q
N
W
-----
A
K
Q
HLPQANREIEPFGVG
K
F
Y
E
LQGPTGESN
Q
Y
I
I
L
PR
H
R
V
L
S
IADT
E
Q
D
Q
L
H
Q
L
L
A
I
F
AVGS
Q
A
A
VMQNSP
L
L
A
K
H
K
QTL
P
K
D
V
L
D
A
I
T
T
IKNIT
T
D
-
D
-
F
D
A
V
L
HHG
N
R
K
E
I
F
S
L
Q
Q
E
I
A
SRS
G
A
I
V
G
I
T
HVEPNE------SI
P
L
E
R
L
V
I
E
R
AISVNTAAAGGN
A
S
L
M
TMSE
1
PsiBlast_PDB
80.16
54%
-52
- C3 -
-
5KF7
7
?
A:
[30-1233]
-------------------------------
Q
S
T
L
R
R
A
I
T
A
A
Y
R
R
P
E
T
E
C
L
P
P
L
V
E
A
A
T
Q
S
K
E
I
R
D
A
A
A
S
T
A
R
K
L
I
E
A
L
R
G
K
----
G
----
V
E
G
L
V
Q
E
Y
S
L
S
S
Q
E
G
-
V
A
L
M
C
L
A
E
A
L
L
R
I
P
D
T
A
T
R
D
A
L
I
R
D
K
I
A
D
G
N
W
K
S
H
L
---
R
S
L
F
V
N
A
A
T
W
G
L
V
V
T
G
K
L
T
---
S
T
V
N
D
R
S
L
A
A
A
L
T
R
L
I
S
R
C
G
E
P
V
I
R
R
G
V
D
M
A
M
R
M
M
G
E
Q
F
V
T
G
E
T
I
R
E
A
L
K
R
S
K
E
L
E
E
K
G
F
S
Y
S
Y
D
M
L
G
E
A
A
T
T
A
A
D
A
E
R
Y
Y
R
D
Y
E
S
A
I
H
A
I
G
K
A
S
A
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
K
L
S
A
L
H
P
R
Y
S
R
A
Q
A
A
R
V
M
G
E
L
L
P
R
V
K
A
L
A
L
L
A
K
N
Y
D
I
G
L
N
I
D
A
E
E
A
D
R
L
E
L
S
L
D
L
L
E
V
L
C
L
D
G
D
L
S
G
W
N
G
M
G
F
V
V
Q
A
Y
G
K
R
C
P
F
V
L
D
F
I
I
D
L
A
R
R
S
G
R
R
I
M
V
R
L
V
K
G
A
Y
W
D
A
E
I
K
R
A
Q
L
D
G
L
A
D
F
P
V
F
T
R
K
I
H
T
D
V
S
Y
I
A
C
A
A
K
L
L
A
A
T
D
V
V
F
P
Q
F
A
T
H
N
A
Q
T
L
A
A
I
Y
H
M
A
G
-
K
D
F
H
V
G
K
Y
E
F
Q
C
L
H
G
M
G
E
P
L
Y
E
E
V
V
G
---
R
G
K
L
D
R
P
C
R
I
Y
A
P
V
G
T
H
E
T
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
H
R
I
N
D
P
K
V
S
I
D
E
L
I
A
D
P
V
E
V
V
R
A
M
P
----
V
V
G
A
K
H
D
R
I
A
L
P
A
E
L
F
G
-
D
A
R
T
N
S
A
G
L
D
L
S
N
E
E
T
L
A
S
L
T
E
A
L
R
E
S
A
A
-
M
-
K
W
T
A
L
P
Q
L
A
T
G
P
A
--
A
G
E
T
R
T
V
L
N
P
G
D
H
R
D
V
V
G
S
V
T
E
T
S
E
E
D
A
R
R
A
V
R
L
A
A
D
A
---
A
P
D
W
A
A
V
P
P
S
E
R
A
A
C
L
D
R
A
A
E
L
M
Q
A
R
M
P
T
L
L
G
L
I
I
R
E
A
G
K
S
A
L
N
A
-
I
A
E
V
R
E
A
I
D
F
L
R
Y
Y
A
--------
E
Q
T
R
R
T
LG-----------
P
-------------
G
-------------
H
-------------------------
G
P
-------------
L
G
P
I
V
C
I
S
P
W
N
F
P
L
A
I
F
T
G
Q
I
A
A
A
L
V
A
G
N
P
V
L
A
K
P
A
E
E
T
P
L
I
A
A
E
G
V
R
I
L
R
E
A
G
I
P
A
S
A
L
Q
L
L
P
G
D
G
R
-
V
G
A
A
L
V
A
A
A
E
T
A
G
V
M
F
T
G
S
T
E
V
A
-
R
L
I
Q
A
Q
L
A
D
R
L
S
P
A
G
R
P
I
P
L
I
A
--
E
T
G
G
Q
N
A
M
I
V
D
S
S
A
L
A
E
Q
V
V
G
D
V
I
T
S
A
F
D
S
A
G
Q
R
C
S
A
L
R
V
L
C
L
Q
E
D
V
A
D
R
I
L
T
M
L
K
G
A
L
H
E
L
H
I
G
R
T
D
R
L
S
V
D
V
G
P
V
I
T
S
E
A
K
D
N
I
E
K
H
I
E
R
M
R
G
L
G
R
K
V
E
Q
I
--
G
L
A
S
E
T
G
V
--
G
T
F
V
P
P
T
I
I
-
E
L
E
K
--
L
S
D
L
---
Q
R
----
E
V
F
G
P
V
L
H
V
I
R
Y
R
R
D
D
L
D
R
L
V
D
D
V
N
A
T
G
Y
G
L
T
F
G
L
H
T
R
-
L
D
E
T
I
A
H
V
T
S
R
I
K
A
G
N
L
Y
I
N
R
N
I
I
G
A
V
V
G
V
Q
-
P
F
G
G
R
G
L
S
G
T
G
P
K
A
G
G
P
L
Y
L
G
R
L
-------
V
T
T
A
P
V
P
P
Q
H
S
S
V
-------
H
T
-
D
P
V
L
L
D
F
A
K
W
L
D
G
K
G
A
R
A
E
A
E
A
A
R
N
A
G
S
S
S
A
L
G
L
D
L
E
L
P
G
P
V
G
E
R
N
L
Y
T
L
H
A
R
G
R
I
L
L
V
P
A
T
E
S
G
L
Y
H
Q
L
A
A
A
L
A
T
G
N
S
V
A
I
D
A
A
S
G
L
Q
A
S
L
K
N
-
L
P
Q
T
V
G
L
R
V
S
W
S
K
D
W
A
A
D
-
G
P
F
A
G
A
L
V
E
G
D
A
E
R
I
R
A
V
N
K
A
I
A
A
L
P
G
P
L
L
L
V
Q
A
A
S
S
G
E
I
A
R
N
P
D
A
Y
C
L
N
W
L
V
E
E
V
S
A
S
I
N
T
A
A
A
G
G
N
A
S
L
M
A
---
109
Fugue
79.04
49%
-43
- C3 -
-
4Q71
4
?
A:
[3-990]
M
P
N
I
P
-------------------------------
P
P
F
T
A
P
Y
A
P
D
D
A
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I
A
A
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L
L
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A
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H
L
S
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P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
K
R
L
------
G
G
V
E
D
M
L
R
E
F
A
L
S
T
K
E
G
-
L
A
L
M
V
L
A
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A
L
L
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V
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A
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A
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L
V
N
A
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A
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A
R
V
I
Q
P
G
-----
E
T
P
D
-----
G
T
I
G
R
L
V
K
R
L
G
A
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A
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R
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A
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A
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N
H
F
V
L
G
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E
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A
L
E
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--
P
G
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M
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G
A
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A
A
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A
R
R
Y
F
D
A
Y
A
S
A
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E
T
I
G
K
A
A
G
N
H
--------------
A
L
P
D
R
P
G
I
S
V
K
L
S
A
L
H
P
R
F
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A
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A
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V
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L
L
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L
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A
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A
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L
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L
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L
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A
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L
A
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L
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G
W
D
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F
G
L
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A
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Q
K
R
A
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A
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L
A
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L
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A
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L
L
A
L
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F
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N
A
L
T
V
A
T
V
L
E
M
A
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G
S
S
----
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
K
D
H
A
----
D
I
A
Y
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Y
A
P
V
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L
L
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L
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A
N
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F
V
A
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A
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Y
R
V
P
V
P
A
L
L
Q
------
R
P
A
D
A
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V
R
P
Q
A
A
A
H
P
R
I
P
L
P
C
D
L
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A
-
P
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S
R
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V
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F
G
A
R
T
A
L
D
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L
L
T
D
V
K
A
---------------------------------------
E
I
A
D
A
T
P
D
Q
A
H
A
A
V
A
A
A
R
A
G
---
F
A
G
W
S
R
T
P
A
G
I
R
A
A
A
L
E
Q
A
A
H
L
L
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R
S
A
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A
L
L
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G
G
K
T
L
D
D
A
-
L
S
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L
R
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A
A
D
F
C
R
Y
Y
A
--------
A
Q
G
R
K
L
FG
S
E
T
A
M
P
G
P
T
G
E
S
-------------
N
-------------
A
L
T
-----------
M
-----------
R
G
-------------
R
G
V
F
V
A
I
S
P
W
N
F
P
L
A
I
F
L
G
Q
V
T
A
A
L
M
A
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N
S
V
V
A
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P
A
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A
L
L
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A
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L
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-
D
G
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-
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A
L
A
A
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---
D
G
P
I
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P
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--
E
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A
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A
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A
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Q
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A
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A
R
M
K
T
E
A
----
R
L
H
F
A
G
P
A
P
----
E
G
C
F
V
A
P
H
I
F
-
E
L
T
E
--
A
G
Q
L
---
T
E
----
E
V
F
G
P
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V
R
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-
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N
M
I
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A
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V
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-
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F
G
G
N
G
L
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G
T
G
P
K
A
G
G
P
H
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
A
A
-----------
84
HHSearch
78.21
47%
-44
- C3 -
-
3HAZ
6
?
A:
[3-988]
-------------------------------
M
P
N
I
P
P
P
F
T
A
P
Y
A
P
D
D
A
E
I
A
A
R
L
L
P
A
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H
L
S
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
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A
I
R
K
R
-----
R
L
G
G
V
E
D
M
L
R
E
F
A
L
S
T
K
E
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-
L
A
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A
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A
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L
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T
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A
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A
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A
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A
----
A
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---
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-
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-
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R
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A
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A
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A
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G
K
A
A
G
N
H
--------------
A
L
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A
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A
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V
L
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M
A
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G
----
S
S
G
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F
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L
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G
M
G
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A
L
Y
E
Q
L
A
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D
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A
----
D
I
A
Y
R
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Y
A
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H
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L
L
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Y
R
V
P
V
P
A
L
L
Q
R
P
A
D
A
I
V
R
P
------
Q
A
A
A
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P
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P
L
P
C
D
L
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A
-
P
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R
R
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R
G
V
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F
G
A
R
T
A
L
D
Q
L
L
T
D
V
K
-------------------------------
A
E
T
-
G
-
D
L
K
P
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A
D
A
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P
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A
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A
A
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A
A
A
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A
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---
F
A
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W
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A
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A
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A
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L
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L
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A
-
L
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L
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A
A
D
F
C
R
Y
Y
A
--------
A
Q
G
R
K
L
-------------
F
-------------
G
S
E
T
A
M
P
G
P
T
G
E
S
N
A
L
T
-----------
M
-----------
R
G
-------------
R
G
V
F
V
A
I
S
P
W
N
F
P
L
A
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L
G
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V
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A
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A
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L
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---
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G
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A
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A
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A
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A
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A
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A
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A
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L
L
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A
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M
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A
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A
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A
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A
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L
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A
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T
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A
R
L
H
F
A
G
P
A
--------
P
E
G
C
F
V
A
P
H
I
F
-
E
L
T
E
--
A
G
Q
L
---
T
E
----
E
V
F
G
P
I
L
H
V
V
R
Y
R
P
E
N
L
E
R
V
L
R
A
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T
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Y
G
L
T
L
G
V
H
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-
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D
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A
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Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
V
V
G
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-
P
F
G
G
N
G
L
S
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G
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A
G
G
P
H
Y
L
A
R
F
A
T
E
Q
T
V
T
I
N
T
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
HHSearch
77.51
55%
-6
- C3 -
-
5KF7
7
?
A:
[16-1233]
-----------------
A
P
A
P
F
A
D
F
APP
V
R
P
Q
S
T
L
R
R
A
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T
A
A
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R
R
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C
L
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K
E
I
R
D
A
A
A
S
T
A
R
K
L
I
E
A
L
R
G
K
--------
G
V
E
G
L
V
Q
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Y
S
L
S
S
Q
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-
V
A
L
M
C
L
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A
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A
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A
L
I
R
D
K
I
A
D
G
N
W
K
S
H
L
---
R
S
L
F
V
N
A
A
T
W
G
L
V
V
T
G
K
L
T
---
S
T
V
N
D
R
S
L
A
A
A
L
T
R
L
I
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R
C
G
E
P
V
I
R
R
G
V
D
M
A
M
R
M
M
G
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F
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T
G
E
T
I
R
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A
L
K
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K
E
L
E
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K
G
F
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Y
S
Y
D
M
L
G
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A
A
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A
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A
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R
Y
Y
R
D
Y
E
S
A
I
H
A
I
G
K
A
S
A
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
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L
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A
L
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G
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A
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V
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P
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A
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A
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A
A
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H
M
A
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C
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M
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L
Y
E
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V
V
G
R
G
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---
L
D
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C
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Y
A
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L
L
A
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L
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R
L
L
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A
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S
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A
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L
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A
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A
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M
-
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W
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L
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A
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V
G
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R
A
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A
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---
A
P
D
W
A
A
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P
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A
A
C
L
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A
A
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A
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M
P
T
L
L
G
L
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A
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A
L
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A
-
I
A
E
V
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A
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L
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Y
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A
--------
E
Q
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R
R
T
-------------
L
-------------
G
--------------
P
G
-----------
H
-----------
G
P
-------------
L
G
P
I
V
C
I
S
P
W
N
F
P
L
A
I
F
T
G
Q
I
A
A
A
L
V
A
G
N
P
V
L
A
K
P
A
E
E
T
P
L
I
A
A
E
G
V
R
I
L
R
E
A
G
I
P
A
S
A
L
Q
L
L
P
G
D
G
R
-
V
G
A
A
L
V
A
A
A
E
T
A
G
V
M
F
T
G
S
T
E
V
A
-
R
L
I
Q
A
Q
L
A
D
R
L
S
P
A
G
R
P
I
P
L
I
A
--
E
T
G
G
Q
N
A
M
I
V
D
S
S
A
L
A
E
Q
V
V
G
D
V
I
T
S
A
F
D
S
A
G
Q
R
C
S
A
L
R
V
L
C
L
Q
E
D
V
A
D
R
I
L
T
M
L
K
G
A
L
H
E
L
H
I
G
R
T
D
R
L
S
V
D
V
G
P
V
I
T
S
E
A
K
D
N
I
E
K
H
I
E
R
M
R
G
L
G
R
K
V
E
Q
I
G
L
A
S
----
E
T
G
V
G
T
F
V
P
P
T
I
I
-
E
L
E
K
--
L
S
D
L
---
Q
R
----
E
V
F
G
P
V
L
H
V
I
R
Y
R
R
D
D
L
D
R
L
V
D
D
V
N
A
T
G
Y
G
L
T
F
G
L
H
T
R
-
L
D
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T
I
A
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V
T
S
R
I
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A
G
N
L
Y
I
N
R
N
I
I
G
A
V
V
G
V
Q
-
P
F
G
G
R
G
L
S
G
T
G
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K
A
G
G
P
L
Y
L
G
R
L
V
T
T
A
P
V
P
P
Q
H
S
S
V
--
H
T
-
D
P
V
L
L
D
F
A
K
W
L
D
G
K
G
A
R
A
E
A
E
A
-----
A
R
N
A
-------
G
S
S
S
A
L
G
L
D
L
E
L
P
G
P
V
G
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N
L
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T
L
H
A
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R
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L
L
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P
A
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L
Y
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Q
L
A
A
A
L
A
T
G
N
S
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A
I
D
A
A
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G
L
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-
A
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L
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N
L
P
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L
R
V
S
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S
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D
W
A
A
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G
P
-
F
A
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A
L
V
E
G
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A
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R
I
R
A
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N
K
A
I
A
A
L
P
G
P
L
L
L
V
Q
A
A
S
S
G
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I
A
R
N
P
D
A
Y
C
L
N
W
L
V
E
E
V
S
A
S
I
N
T
A
A
A
G
G
N
A
S
L
M
A
---
2
PsiBlast_PDB
75.66
46%
-5
- C3 -
-
3HAZ
6
?
A:
[20-977]
------------------------------------------------
E
I
A
A
R
L
L
P
A
S
H
L
S
P
P
Q
E
A
R
I
H
R
T
A
T
R
L
I
E
A
I
R
K
R
-----
R
L
G
G
V
E
D
M
L
R
E
F
A
L
S
T
K
E
G
-
L
A
L
M
V
L
A
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A
L
L
R
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P
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A
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G
D
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H
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T
K
S
T
A
F
L
V
N
A
S
A
W
A
----
A
R
V
I
Q
P
G
E
T
P
D
G
T
-----
I
G
R
L
V
K
R
L
G
A
P
A
V
R
T
A
T
R
Q
A
M
R
L
M
G
N
H
F
V
L
G
E
T
I
E
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A
L
E
R
G
K
P
R
S
G
Q
K
T
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Y
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F
D
M
L
G
E
G
A
R
T
A
A
D
A
R
R
Y
F
D
A
Y
A
S
A
I
E
T
I
G
K
A
A
G
N
H
--------------
A
L
P
D
R
P
G
I
S
V
K
L
S
A
L
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P
R
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A
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A
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A
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L
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L
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V
I
A
A
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L
A
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P
S
L
K
G
W
D
G
F
G
L
A
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A
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Q
K
R
A
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A
V
I
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Y
V
D
A
L
A
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A
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L
M
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L
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A
Y
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L
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P
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A
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L
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Y
V
A
C
A
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L
L
A
L
R
P
R
I
F
P
Q
F
A
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H
N
A
L
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V
A
T
V
L
E
M
A
E
G
S
S
----
G
F
E
F
Q
R
L
H
G
M
G
E
A
L
Y
E
Q
L
A
----
K
D
H
A
D
I
A
Y
R
T
Y
A
P
V
G
S
H
R
D
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
S
S
F
V
A
Q
A
A
D
Y
R
V
P
V
P
A
L
L
Q
R
P
------
A
D
A
I
V
R
P
Q
A
A
A
H
P
R
I
P
L
P
C
D
L
F
A
-
P
E
R
R
N
S
R
G
V
E
F
G
A
R
T
---
A
L
D
Q
L
L
T
D
V
K
------------
A
E
T
G
D
L
K
---
P
I
A
D
A
T
P
D
Q
A
---------------
H
A
A
V
A
A
A
R
A
G
---
F
A
G
W
S
R
T
P
A
G
I
R
A
A
A
L
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A
A
H
L
L
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R
S
A
H
F
I
A
L
L
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R
E
G
G
K
T
L
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D
A
-
L
S
E
L
R
E
A
A
D
F
C
R
Y
Y
A
--------
A
Q
G
R
K
L
-------------
F
-------------
G
-------------
S
E
T
-----------
A
-----------
M
P
G
P
T
G
E
S
N
A
L
T
M
R
G
R
G
V
F
V
A
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P
W
N
F
P
L
A
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F
L
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A
A
L
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A
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V
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A
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A
L
L
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A
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A
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Y
L
V
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-
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A
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V
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A
-
R
S
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N
R
A
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A
---
A
K
D
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P
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L
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A
--
E
T
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G
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A
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A
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A
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A
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A
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A
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A
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A
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M
K
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----
R
L
H
F
A
G
P
A
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----
E
G
C
F
V
A
P
H
I
F
-
E
L
T
E
--
A
G
Q
L
---
T
E
----
E
V
F
G
P
I
L
H
V
V
R
Y
R
P
E
N
L
E
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L
R
A
I
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R
T
G
Y
G
L
T
L
G
V
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S
R
-
I
D
D
S
I
E
A
I
I
D
R
V
Q
V
G
N
I
Y
V
N
R
N
M
I
G
A
V
V
G
V
Q
-
P
F
G
G
N
G
L
S
G
T
G
P
K
A
G
G
P
H
Y
L
A
R
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
HHSearch
64.13
31%
8
- C3 -
-
4NMD
10
?
B:
[43-990]
---------------------------------------------------------------------------------------------------
S
M
Q
N
E
Q
F
K
I
Q
M
F
R
F
V
D
V
F
P
S
L
T
T
S
K
--------------------
L
L
T
E
H
I
R
E
Y
F
G
N
-
E
Q
D
M
P
A
F
M
------------------------
A
V
L
N
K
V
L
T
S
N
I
E
E
M
A
R
Q
F
I
V
G
E
T
T
K
E
A
V
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N
L
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L
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A
A
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V
D
V
L
G
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A
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L
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E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
Q
G
S
W
KGLPGKGGDPGLDW
G
H
A
P
K
V
N
I
A
V
K
P
T
A
L
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C
L
A
N
P
Q
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V
V
A
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R
R
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K
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M
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F
L
C
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M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
--
Y
R
D
Y
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
A
W
A
K
E
H
K
V
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V
R
L
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A
Y
W
D
Y
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T
V
K
A
K
Q
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D
W
E
-
V
P
V
W
T
I
K
A
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D
A
A
Y
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Q
A
R
K
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L
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N
H
Q
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H
F
A
C
A
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V
M
E
M
A
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Y
E
F
Q
V
L
Y
G
M
A
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V
R
K
G
I
L
K
V
A
------
G
R
I
R
L
Y
A
P
Y
G
N
M
V
P
G
M
G
Y
L
V
R
R
L
L
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A
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L
L
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D
P
A
V
T
V
E
-------
R
E
R
A
A
R
A
A
K
----
G
L
G
G
L
P
P
F
N
N
E
A
M
V
D
F
T
R
A
D
H
R
A
A
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H
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-
Q
L
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Y
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L
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N
D
L
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P
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G
Q
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Q
A
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G
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A
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A
A
A
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A
A
---
F
P
A
W
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D
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R
T
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A
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Y
L
L
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A
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Y
A
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A
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D
F
L
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Y
Y
A
--------
R
E
M
I
R
L
-------------
G
-------------
Q
P
Q
R
V
G
HAPG
E
L
N
-
H
Y
F
-----------
Y
-----------
E
P
-------------
K
G
V
A
A
V
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A
P
W
N
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P
L
A
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M
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M
A
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L
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K
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--
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A
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D
D
D
A
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L
D
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Y
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A
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G
F
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C
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A
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V
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L
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A
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A
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A
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A
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M
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A
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A
D
D
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A
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I
K
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Y
A
E
I
G
K
R
E
G
H
V
L
Y
E
S
P
V
------
P
A
G
E
G
Y
F
V
P
M
T
I
I
-
G
G
I
K
PE
H
R
I
A
---
Q
E
----
E
I
F
G
P
V
L
A
V
M
R
A
K
--
D
F
D
Q
A
I
E
W
A
N
S
T
Q
F
A
L
T
G
G
I
F
S
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-
S
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L
A
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A
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V
G
N
L
Y
I
N
R
N
N
T
G
A
L
V
E
R
Q
-
P
F
G
G
A
R
M
S
G
V
G
T
K
A
G
G
P
D
Y
L
L
H
F
M
D
P
R
V
V
T
E
N
T
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
63.92
31%
8
- C3 -
-
4NM9
14
?
B:
[43-990]
---------------------------------------------------------------------------------------------------
S
M
Q
N
E
Q
F
K
I
Q
M
F
R
F
V
D
V
F
P
S
L
T
T
S
K
--------------------
L
L
T
E
H
I
R
E
Y
F
G
N
-
E
Q
D
M
P
A
F
M
------------------------
A
V
L
N
K
V
L
T
S
N
I
E
E
M
A
R
Q
F
I
V
G
E
T
T
K
E
A
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K
N
L
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K
L
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K
D
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F
A
A
V
V
D
V
L
G
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A
T
L
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E
E
E
A
E
V
Y
T
N
T
Y
L
E
L
L
E
A
L
K
K
E
Q
G
S
W
KGLPGKGGDPGLDW
G
H
A
P
K
V
N
I
A
V
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P
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A
L
F
C
L
A
N
P
Q
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V
A
I
L
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M
R
R
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K
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G
F
L
C
I
D
M
E
S
Y
R
H
K
E
I
I
L
E
V
F
R
R
L
K
L
E
--
Y
R
D
Y
P
H
L
G
I
V
L
Q
A
Y
L
K
D
N
D
K
D
L
D
D
L
L
A
W
A
K
E
H
K
V
Q
I
S
V
R
L
V
K
G
A
Y
W
D
Y
E
T
V
K
A
K
Q
N
D
W
E
-
V
P
V
W
T
I
K
A
E
S
D
A
A
Y
E
R
Q
A
R
K
I
L
E
N
H
Q
I
C
H
F
A
C
A
S
H
N
I
R
T
I
S
A
V
M
E
M
A
R
E
L
N
V
P
E
D
R
Y
E
F
Q
V
L
Y
G
M
A
E
P
V
R
K
G
I
L
K
V
A
------
G
R
I
R
L
Y
A
P
Y
G
N
M
V
P
G
M
G
Y
L
V
R
R
L
L
E
N
T
A
N
E
S
F
L
R
Q
S
F
A
E
D
A
Q
I
E
R
L
L
E
D
P
A
V
T
V
E
-------
R
E
R
A
A
R
A
A
K
----
G
L
G
G
L
P
P
F
N
N
E
A
M
V
D
F
T
R
A
D
H
R
A
A
F
P
K
H
I
A
Q
V
R
T
-
Q
L
G
K
T
Y
P
L
F
I
N
G
K
E
V
R
T
-
N
D
L
I
P
T
V
N
P
N
K
P
S
E
V
L
G
Q
I
C
Q
A
G
T
T
E
V
G
D
A
I
A
A
A
K
A
A
---
F
P
A
W
R
D
T
D
P
R
T
R
A
E
Y
L
L
K
A
A
Q
A
A
R
K
R
L
F
E
L
S
A
W
Q
V
L
E
I
G
K
Q
W
D
Q
A
-
Y
A
D
V
T
E
A
I
D
F
L
E
Y
Y
A
--------
R
E
M
I
R
L
-------------
G
-------------
Q
P
Q
R
V
G
HAPG
E
L
N
-
H
Y
F
-----------
Y
-----------
E
P
-------------
K
G
V
A
A
V
I
A
P
W
N
F
P
L
A
I
S
M
G
M
A
S
A
A
I
V
T
G
N
C
V
V
F
K
P
S
G
I
T
S
I
I
G
W
H
L
V
E
L
F
R
E
A
G
L
P
E
G
V
F
N
F
T
P
G
R
G
S
V
M
G
D
Y
L
V
D
H
P
D
I
S
L
I
A
F
T
G
S
M
E
T
G
-
L
R
I
I
E
R
A
A
K
V
H
P
G
Q
A
N
V
K
K
I
I
S
--
E
M
G
G
K
N
A
I
I
I
D
D
D
A
D
L
D
E
A
V
P
H
V
L
Y
S
A
F
G
F
Q
G
Q
K
C
S
A
C
S
R
V
I
V
L
D
A
V
Y
D
K
F
I
E
R
L
V
S
M
A
K
A
T
K
V
G
P
S
E
D
P
A
N
Y
M
G
A
V
A
D
D
K
A
M
K
S
I
K
E
Y
A
E
I
G
K
R
E
G
H
V
L
Y
E
S
P
V
------
P
A
G
E
G
Y
F
V
P
M
T
I
I
-
G
G
I
K
PE
H
R
I
A
---
Q
E
----
E
I
F
G
P
V
L
A
V
M
R
A
K
--
D
F
D
Q
A
I
E
W
A
N
S
T
Q
F
A
L
T
G
G
I
F
S
R
-
S
P
E
H
L
A
K
A
R
R
E
F
R
V
G
N
L
Y
I
N
R
N
N
T
G
A
L
V
E
R
Q
-
P
F
G
G
A
R
M
S
G
V
G
T
K
A
G
G
P
D
Y
L
L
H
F
M
D
P
R
V
V
T
E
N
T
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.90
65%
-115
- C2 -
-
1TJ1
2
PUTA_ECOLI
A:
[10-525]
--------------------------------------
I
T
A
A
Y
R
R
P
E
T
E
A
V
S
M
L
L
E
Q
A
R
L
P
Q
P
V
A
E
Q
A
H
K
L
A
Y
Q
L
A
D
K
L
R
N
Q
K
N
A
S
G
R
A
G
M
--------------
G
-
V
A
L
M
C
L
A
E
A
L
L
R
I
P
D
K
A
T
R
D
A
L
I
R
--------------------------------------------------------------
K
G
V
D
M
A
M
R
L
M
G
E
Q
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
G
K
A
S
N
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
K
L
S
A
L
H
P
R
Y
S
R
A
Q
Y
D
R
V
M
E
E
L
Y
P
R
L
K
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
D
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
E
P
E
L
A
G
W
N
G
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
A
T
R
S
R
R
R
L
M
I
R
L
V
K
G
A
Y
W
D
S
E
I
K
R
A
Q
M
D
G
L
E
G
Y
P
V
Y
T
R
K
V
Y
T
D
V
S
Y
L
A
C
A
K
K
L
L
A
V
P
N
L
I
Y
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
-
Q
N
Y
Y
P
G
Q
Y
E
F
Q
C
L
H
G
M
G
E
P
L
Y
E
Q
V
T
G
K
V
A
D
G
K
L
N
R
P
C
R
I
Y
A
P
V
G
T
H
E
T
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
T
S
F
V
N
R
I
A
D
T
S
L
P
L
D
E
L
V
A
D
P
V
T
A
V
E
K
L
A
Q
Q
E
G
Q
T
G
L
P
H
P
K
I
P
L
P
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.80
65%
-116
- C2 -
-
2FZN
2
PUTA_ECOLI
A:
[10-525]
--------------------------------------
I
T
A
A
Y
R
R
P
E
T
E
A
V
S
M
L
L
E
Q
A
R
L
P
Q
P
V
A
E
Q
A
H
K
L
A
Y
Q
L
A
D
K
L
R
N
Q
K
N
A
S
G
R
A
G
---------------
G
-
V
A
L
M
C
L
A
E
A
L
L
R
I
P
D
K
A
T
R
D
A
L
I
R
--------------------------------------------------------------
K
G
V
D
M
A
M
R
L
M
G
E
Q
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
G
K
A
S
N
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
K
L
S
A
L
H
P
R
Y
S
R
A
Q
Y
D
R
V
M
E
E
L
Y
P
R
L
K
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
D
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
E
P
E
L
A
G
W
N
G
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
A
T
R
S
R
R
R
L
M
I
R
L
V
K
G
A
Y
W
D
S
E
I
K
R
A
Q
M
D
G
L
E
G
Y
P
V
Y
T
R
K
V
Y
T
D
V
S
Y
L
A
C
A
K
K
L
L
A
V
P
N
L
I
Y
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
-
Q
N
Y
Y
P
G
Q
Y
E
F
Q
C
L
H
G
M
G
E
P
L
Y
E
Q
V
T
G
K
V
A
D
G
K
L
N
R
P
C
R
I
Y
A
P
V
G
T
H
E
T
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
T
S
F
V
N
R
I
A
D
T
S
L
P
L
D
E
L
V
A
D
P
V
T
A
V
E
K
L
A
Q
Q
E
G
Q
T
G
L
P
H
P
K
I
P
L
P
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
53.78
65%
-111
- C2 -
-
2FZM
2
PUTA_ECOLI
A:
[10-525]
--------------------------------------
I
T
A
A
Y
R
R
P
E
T
E
A
V
S
M
L
L
E
Q
A
R
L
P
Q
P
V
A
E
Q
A
H
K
L
A
Y
Q
L
A
D
K
L
R
N
Q
K
N
A
S
G
R
A
G
M
--------------
G
-
V
A
L
M
C
L
A
E
A
L
L
R
I
P
D
K
A
T
R
D
A
L
I
R
--------------------------------------------------------------
K
G
V
D
M
A
M
R
L
M
G
E
Q
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
G
K
A
S
N
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
K
L
S
A
L
H
P
R
Y
S
R
A
Q
Y
D
R
V
M
E
E
L
Y
P
R
L
K
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
D
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
E
P
E
L
A
G
W
N
G
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
A
T
R
S
R
R
R
L
M
I
R
L
V
K
G
A
Y
W
D
S
E
I
K
R
A
Q
M
D
G
L
E
G
Y
P
V
Y
T
R
K
V
Y
T
D
V
S
Y
L
A
C
A
K
K
L
L
A
V
P
N
L
I
Y
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
-
Q
N
Y
Y
P
G
Q
Y
E
F
Q
C
L
H
G
M
G
E
P
L
Y
E
Q
V
T
G
K
V
A
D
G
K
L
N
R
P
C
R
I
Y
A
P
V
G
T
H
E
T
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
T
S
F
V
N
R
I
A
D
T
S
L
P
L
D
E
L
V
A
D
P
V
T
A
V
E
K
L
A
Q
Q
E
G
Q
T
G
L
P
H
P
K
I
P
L
P
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
53.40
65%
-113
- C2 -
-
1TJ2
1
PUTA_ECOLI
A:
[10-525]
--------------------------------------
I
T
A
A
Y
R
R
P
E
T
E
A
V
S
M
L
L
E
Q
A
R
L
P
Q
P
V
A
E
Q
A
H
K
L
A
Y
Q
L
A
D
K
L
R
N
Q
K
N
A
S
G
R
A
G
M
--------------
G
-
V
A
L
M
C
L
A
E
A
L
L
R
I
P
D
K
A
T
R
D
A
L
I
R
--------------------------------------------------------------
K
G
V
D
M
A
M
R
L
M
G
E
Q
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
G
K
A
S
N
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
K
L
S
A
L
H
P
R
Y
S
R
A
Q
Y
D
R
V
M
E
E
L
Y
P
R
L
K
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
D
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
E
P
E
L
A
G
W
N
G
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
A
T
R
S
R
R
R
L
M
I
R
L
V
K
G
A
Y
W
D
S
E
I
K
R
A
Q
M
D
G
L
E
G
Y
P
V
Y
T
R
K
V
Y
T
D
V
S
Y
L
A
C
A
K
K
L
L
A
V
P
N
L
I
Y
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
-
Q
N
Y
Y
P
G
Q
Y
E
F
Q
C
L
H
G
M
G
E
P
L
Y
E
Q
V
T
G
K
V
A
D
G
K
L
N
R
P
C
R
I
Y
A
P
V
G
T
H
E
T
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
T
S
F
V
N
R
I
A
D
T
S
L
P
L
D
E
L
V
A
D
P
V
T
A
V
E
K
L
A
Q
Q
E
G
Q
T
G
L
P
H
P
K
I
P
L
P
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
53.38
64%
-122
- C2 -
-
4JNZ
4
PUTA_ECOLI
A:
[10-525]
--------------------------------------
I
T
A
A
Y
R
R
P
E
T
E
A
V
S
M
L
L
E
Q
A
R
L
P
Q
P
V
A
E
Q
A
H
K
L
A
Y
Q
L
A
D
K
L
R
N
Q
K
N
A
S
G
R
A
G
M
V
Q
G
L
L
Q
E
F
S
L
S
S
Q
E
G
-
V
A
L
M
C
L
A
E
A
L
L
R
I
P
D
K
A
T
R
D
A
L
I
R
D
----------------
L
F
V
N
A
A
T
W
G
L
L
F
-------------
A
S
L
S
R
S
L
N
R
I
I
-----
P
L
I
R
K
G
V
D
M
A
M
R
L
M
G
E
Q
F
V
T
G
E
T
I
A
E
A
L
A
N
A
R
K
L
E
E
K
G
F
R
Y
S
Y
D
M
L
G
E
A
A
L
T
A
A
D
A
Q
A
Y
M
V
S
Y
Q
Q
A
I
H
A
I
G
K
A
S
N
G
R
--------------
G
I
Y
E
G
P
G
I
S
I
K
L
S
A
L
H
P
R
Y
S
R
A
Q
Y
D
R
V
M
E
E
L
Y
P
R
L
K
S
L
T
L
L
A
R
Q
Y
D
I
G
I
N
I
N
A
E
E
S
D
R
L
E
I
S
L
D
L
L
E
K
L
C
F
E
P
E
L
A
G
W
N
G
I
G
F
V
I
Q
A
Y
Q
K
R
C
P
L
V
I
D
Y
L
I
D
L
A
T
R
S
R
R
R
L
M
I
R
L
V
K
G
A
Y
W
D
S
E
I
K
R
A
Q
M
D
G
L
E
G
Y
P
V
Y
T
R
K
V
Y
T
D
V
S
Y
L
A
C
A
K
K
L
L
A
V
P
N
L
I
Y
P
Q
F
A
T
H
N
A
H
T
L
A
A
I
Y
Q
L
A
G
-
Q
N
Y
Y
P
G
Q
Y
E
F
Q
C
L
H
G
M
G
E
P
L
Y
E
Q
V
T
G
K
V
A
D
G
K
L
N
R
P
C
R
I
Y
A
P
V
G
T
H
E
T
L
L
A
Y
L
V
R
R
L
L
E
N
G
A
N
T
S
F
V
N
R
I
A
D
T
S
L
P
L
D
E
L
V
A
D
P
V
T
A
V
E
K
L
A
Q
Q
E
G
Q
T
G
L
P
H
P
K
I
P
L
P
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
53.30
36%
-10
- C3 -
-
2IY6
9
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
53.08
36%
-7
- C3 -
-
2EIW
7
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
53.06
36%
-9
- C3 -
-
2EIW
7
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
N
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.02
36%
-10
- C3 -
-
2BHP
9
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
52.98
36%
-10
- C3 -
-
2EHU
12
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
52.92
36%
-9
- C3 -
-
2EHQ
6
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
52.90
36%
-8
- C3 -
-
2J5N
9
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
52.77
32%
14
- C3 -
-
3QAN
-
ROCA1_BACHD
B:
[5-516]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Y
K
H
E
P
F
T
D
F
T
V
E
A
N
R
K
A
F
E
E
A
L
G
L
V
E
K
E
L
-
G
K
E
Y
P
L
I
I
N
G
E
R
V
T
T
-
E
D
K
I
Q
S
W
N
P
A
R
K
D
Q
L
V
G
S
V
S
K
A
N
Q
D
L
A
E
K
A
I
Q
S
A
D
E
A
---
F
Q
T
W
R
N
V
N
P
E
E
R
A
N
I
L
V
K
A
A
A
I
I
R
R
R
K
H
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F
S
A
W
L
V
H
E
A
G
K
P
W
K
E
A
-
D
A
D
T
A
E
A
I
D
F
L
E
Y
Y
A
--------
R
Q
M
I
E
L
-------------
N
R
G
K
E
I
L
S
R
PG
E
Q
-
N
-------------
R
Y
F
-----------
Y
-----------
T
P
-------------
M
G
V
T
V
T
I
S
P
W
N
F
A
L
A
I
M
V
G
T
A
V
A
P
I
V
T
G
N
T
V
V
L
K
P
A
S
T
T
P
V
V
A
A
K
F
V
E
V
L
E
D
A
G
L
P
K
G
V
I
N
Y
V
P
G
S
G
A
E
V
G
D
Y
L
V
D
H
P
K
T
S
L
I
T
F
T
G
S
K
D
V
G
-
V
R
L
Y
E
R
A
A
V
V
R
P
G
Q
N
H
L
K
R
V
I
V
--
E
M
G
G
K
D
T
V
V
V
D
R
D
A
D
L
D
L
A
A
E
S
I
L
V
S
A
F
G
F
S
G
Q
K
C
S
A
G
S
R
A
V
I
H
K
D
V
Y
D
E
V
L
E
K
T
V
A
L
A
K
N
L
T
V
G
D
P
T
N
R
D
N
Y
M
G
P
V
I
D
E
K
A
F
E
K
I
M
S
Y
I
E
I
G
K
K
E
G
R
L
M
T
G
G
E
G
------
D
S
S
T
G
F
F
I
Q
P
T
I
I
-
A
D
L
D
PE
A
V
I
M
---
Q
E
----
E
I
F
G
P
V
V
A
F
S
K
A
N
--
D
F
D
H
A
L
E
I
A
N
N
T
E
Y
G
L
T
G
A
V
I
T
R
-
N
R
A
H
I
E
Q
A
K
R
E
F
H
V
G
N
L
Y
F
N
R
N
C
T
G
A
I
V
G
Y
H
-
P
F
G
G
F
K
M
S
G
T
D
S
K
A
G
G
P
D
Y
L
A
L
H
M
Q
A
K
T
V
S
E
M
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.74
36%
-9
- C3 -
-
2J5N
8
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
52.73
36%
-11
- C3 -
-
2EIT
9
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
52.68
36%
-7
- C3 -
-
2EJ6
8
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
52.64
36%
-8
- C3 -
-
2EJ6
9
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
52.55
36%
-10
- C3 -
-
2EII
13
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
52.47
36%
-10
- C3 -
-
2BJK
8
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
52.45
36%
-9
- C3 -
-
2EIT
8
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
52.35
36%
-10
- C3 -
-
2EHQ
6
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
HHSearch
52.27
33%
5
- C3 -
-
2EHQ
6
?
A:
[5-513]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
R
N
E
P
I
E
T
F
Q
T
E
E
A
R
R
A
M
R
E
A
L
R
R
V
R
E
E
F
-
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
-
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
--------
R
A
A
L
R
Y
-------------
R
YPA
V
E
V
V
P
Y
P
G
E
D
N
-------------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
F
K
R
A
Y
V
--
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
P
A
-
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
------
E
G
E
G
Y
F
I
A
P
T
V
F
-
T
E
V
P
PK
A
R
I
A
---
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.27
36%
-8
- C3 -
-
2BHQ
9
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
52.23
36%
-10
- C3 -
-
2BJK
7
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
52.18
36%
-10
- C3 -
-
2BHP
7
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
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H
P
R
I
R
F
I
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F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
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E
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A
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D
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V
V
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S
A
Y
G
F
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A
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Y
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-
P
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P
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V
V
S
A
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Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
52.05
36%
-8
- C3 -
-
2BHQ
6
?
B:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
RAALRYRY
P
A
V
E
V
V
-------------
P
-------------
Y
PGEDN--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
YV
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
52.03
33%
4
- C3 -
-
2BHQ
9
?
A:
[5-513]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
R
N
E
P
I
E
T
F
Q
T
E
E
A
R
R
A
M
R
E
A
L
R
R
V
R
E
E
F
-
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
-
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
--------
R
A
A
L
R
Y
-------------
R
YPA
V
E
V
V
P
Y
P
G
E
D
N
-------------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
-
L
K
I
Y
E
A
A
G
R
L
A
P
G
Q
T
W
F
K
R
A
Y
V
--
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
P
A
-
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
Q
L
V
L
G
G
K
R
L
------
E
G
E
G
Y
F
I
A
P
T
V
F
-
T
E
V
P
PK
A
R
I
A
---
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
M
K
A
V
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
52.01
36%
-10
- C3 -
-
2EHU
11
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
51.99
36%
-9
- C3 -
-
2EII
11
?
A:
[22-508]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
R
E
A
L
R
R
V
R
E
-
E
-
F
G
R
H
Y
P
L
Y
I
G
G
E
W
V
D
T
K
E
R
M
V
S
L
N
P
S
A
P
S
E
V
V
G
T
T
A
K
A
G
K
A
E
A
E
A
A
L
E
A
A
W
K
A
---
F
K
T
W
K
D
W
P
Q
E
D
R
S
R
L
L
L
K
A
A
A
L
M
R
R
R
K
R
E
L
E
A
T
L
V
Y
E
V
G
K
N
W
V
E
A
-
S
A
D
V
A
E
A
I
D
F
I
E
Y
Y
A
R
A
A
L
R
Y
RY
P
A
V
E
V
V
-------------
P
-------------
Y
P
G
E
D
N
--------
E
S
F
-----------
Y
-----------
V
P
-------------
L
G
A
G
V
V
I
A
P
W
N
F
P
V
A
I
F
T
G
M
I
V
G
P
V
A
V
G
N
T
V
I
A
K
P
A
E
D
A
V
V
V
G
A
K
V
F
E
I
F
H
E
A
G
F
P
P
G
V
V
N
F
L
P
G
V
G
E
E
V
G
A
Y
L
V
E
H
P
R
I
R
F
I
N
F
T
G
S
L
E
V
G
L
K
I
Y
E
--
A
A
G
R
L
A
P
-
G
Q
T
W
F
K
R
A
Y
V
E
T
G
G
K
D
A
I
I
V
D
E
T
A
D
F
D
L
A
A
E
G
V
V
V
S
A
Y
G
F
Q
G
Q
K
C
S
A
A
S
R
L
I
L
T
Q
G
A
Y
E
P
V
L
E
R
V
L
K
R
A
E
R
L
S
V
G
-
P
A
E
E
N
P
D
L
G
P
V
V
S
A
E
Q
E
R
K
V
L
S
Y
I
E
I
G
K
N
E
G
----
Q
L
V
L
G
G
K
R
L
E
--
G
E
G
Y
F
I
A
P
T
V
F
T
E
V
P
P
--
K
A
R
I
A--
Q
E
----
E
I
F
G
P
V
L
S
V
I
R
V
K
--
D
F
A
E
A
L
E
V
A
N
D
T
P
Y
G
L
T
G
G
V
Y
S
R
-
K
R
E
H
L
E
W
A
R
R
E
F
H
V
G
N
L
Y
F
N
R
K
I
T
G
A
L
V
G
V
Q
-
P
F
G
G
F
K
L
S
G
T
N
A
K
T
G
A
L
D
Y
L
R
L
F
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
51.96
31%
1
- C3 -
-
5AC2
2
AL1A1_HUMAN
A:
[35-500]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
N
D
L
A
G
C
I
K
T
L
R
Y
C
A
--------
G
W
A
D
K
I
-------------
Q
-------------
G
-------------
R
T
I
-----------
P
IDGN
F
F
T
Y
T
R
H
E
P
-------------
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
-
K
L
I
K
E
A
A
G
K
---
S
N
L
K
R
V
T
L
----
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
---
A
K
L
E
C
G
G
G
P
W
G
--
N
K
G
Y
F
V
Q
P
T
V
F
-
S
--
N
--
V
T
D
E
---
M
R
IAKE
E
I
F
G
P
V
Q
Q
I
M
K
F
K
--
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
-
T
I
S
S
A
L
Q
A
G
T
V
W
V
--
N
C
Y
G
V
V
S
A
Q
C
-
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
----
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
I
S
Q
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
51.01
31%
3
- C3 -
-
4WB9
1
AL1A1_HUMAN
A:
[35-500]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
N
D
L
A
G
C
I
K
T
L
R
Y
C
A
--------
G
W
A
D
K
I
-------------
Q
-------------
G
-------------
R
T
I
-----------
P
IDGN
F
F
T
Y
T
R
H
E
P
-------------
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
-
K
L
I
K
E
A
A
G
K
---
S
N
L
K
R
V
T
L
----
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
---
A
K
L
E
C
G
G
G
P
W
G
--
N
K
G
Y
F
V
Q
P
T
V
F
-
S
--
N
--
V
T
D
E
---
M
R
IAKE
E
I
F
G
P
V
Q
Q
I
M
K
F
K
--
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
-
T
I
S
S
A
L
Q
A
G
T
V
W
V
--
N
C
Y
G
V
V
S
A
Q
C
-
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
----
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
I
S
Q
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
50.93
31%
2
- C3 -
-
4X4L
2
AL1A1_HUMAN
A:
[35-500]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
K
F
P
V
F
N
P
A
T
E
E
E
L
C
-
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
P
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
S
D
L
A
G
C
I
K
T
L
R
Y
C
A
--------
G
W
A
D
K
I
-------------
Q
-------------
G
-------------
R
T
I
-----------
P
IDGN
F
F
T
Y
T
R
H
E
P
-------------
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
-
K
L
I
K
E
A
A
G
K
---
S
N
L
K
R
V
T
L
----
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
---
A
K
L
E
C
G
G
G
P
W
G
--
N
K
G
Y
F
V
Q
P
T
V
F
-
S
--
N
--
V
T
D
E
---
M
R
IAKE
E
I
F
G
P
V
Q
Q
I
M
K
F
K
--
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
-
T
I
S
S
A
L
Q
A
G
T
V
W
V
--
N
C
Y
G
V
V
S
A
Q
C
-
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
----
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
I
S
Q
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
49.16
32%
10
- C3 -
-
5AC0
2
AL1A1_SHEEP
B:
[35-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
K
F
P
V
F
N
P
A
T
E
E
K
L
C
-
E
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
P
W
R
T
M
D
A
S
E
R
G
R
L
L
N
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
A
M
N
G
G
K
L
F
S
N
A
Y
L
M
D
L
G
G
C
I
K
T
L
R
Y
C
A
--------
G
W
A
D
K
I
-------------
Q
-------------
G
-------------
R
T
I
PMDGN
F
F
T
Y
T
R
S
-----------
E
P
-------------
V
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
L
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
M
G
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
V
D
K
V
A
F
T
G
S
T
E
V
G
-
K
L
I
K
E
A
A
G
K
---
S
N
L
K
R
V
S
L
----
E
L
G
G
K
S
P
C
I
V
F
A
D
A
D
L
D
N
A
V
E
F
A
H
Q
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
L
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
V
L
G
N
P
L
T
P
G
V
S
Q
G
P
Q
I
D
K
E
Q
Y
E
K
I
L
D
L
I
E
S
G
K
K
E
G
---
A
K
L
E
C
G
G
G
P
W
G
--
N
K
G
Y
F
I
Q
P
T
V
F
-
S
-
D
V
--
T
D
D
M
RIA
K
E
----
E
I
F
G
P
V
Q
Q
I
M
K
F
K
--
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
I
F
T
N
D
I
D
K
A
I
-
T
V
S
S
A
L
Q
S
G
T
V
W
V
N
---
C
Y
S
V
V
S
A
Q
C
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
PsiBlast_CBE
48.12
32%
12
- C3 -
-
5AC0
2
AL1A1_SHEEP
A:
[35-479]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
K
F
P
V
F
N
P
A
T
E
E
K
L
C
-
E
V
E
E
G
D
K
-
D
V
D
K
A
V
K
A
A
R
Q
A
F
QI
G
S
P
W
R
T
M
D
A
S
E
R
G
R
L
L
N
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
A
M
N
G
G
K
L
F
S
N
A
Y
L
M
D
L
G
G
C
I
K
T
L
R
Y
C
A
--------
G
W
A
D
K
I
-------------
Q
-------------
G
-------------
R
T
I
PMDGN
F
F
T
Y
T
R
S
-----------
E
P
-------------
V
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
F
L
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
M
G
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
Y
G
P
T
A
G
A
A
I
S
S
H
M
D
V
D
K
V
A
F
T
G
S
T
E
V
G
-
K
L
I
K
E
A
A
G
K
---
S
N
L
K
R
V
S
L
----
E
L
G
G
K
S
P
C
I
V
F
A
D
A
D
L
D
N
A
V
E
F
A
H
Q
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
R
L
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
V
L
G
N
P
L
T
P
G
V
S
Q
G
P
Q
I
D
K
E
Q
Y
E
K
I
L
D
L
I
E
S
G
K
K
E
G
---
A
K
L
E
C
G
G
G
P
W
G
--
N
K
G
Y
F
I
Q
P
T
V
F
-
S
-
D
V
--
T
D
D
M
RIA
K
E
----
E
I
F
G
P
V
Q
Q
I
M
K
F
K
--
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
I
F
T
N
D
I
D
K
A
I
-
T
V
S
S
A
L
Q
S
G
T
V
W
V
N
---
C
Y
S
V
V
S
A
Q
C
P
F
G
G
F
K
M
S
G
N
G
R
E
L
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------