@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR22: (2017-11-30 )
MTSSYRQQLQAKIDRITTQFSEFTPPTLEVFESPEQHFRMRAEFRIWHTENDMFYAMFERNDDGKQKTVVRIDEFPIADKSINDLMPLLLAELKANSLLSQRLFEVDFLATLSGEMLVTLIYHRKLNQEWEQAAKALAEKLNIKIMGRSRGQKIVIGDDFVVEEFELLNRSFKYKQIESSFTQPNAQVCKKMLQWACDAAEGSKKHLLELYCGNGNFTLPLSLKFERVLATELAKSSVYAAQWNIEQNQIDNIQVARLSAEEFTQAYQGEREFRRLQEADIDIQSYDFGTVFVDPPRAGIDDETLKLLQGFERIIYISCNPDTLYENLKTLTQTHRVTKFALFDQFPYTHHVESGVLLEKI
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........20..-......30........40........50-.........60........70...---.....80........90....----....100..--...----..110.......120.......130.....-----..--140----.-----.---.-.....150.......----160.......170.......180.........190.......200.-.......210.......220..--.-.-...230.......240.......--250-.-.......260.......270.......280....---...290.....---------------.--.---300-.-----------.-....-----.--.---310.--....------...----320-..---.---.-....330--..--------.--.--.....------340---...-----.-...350.......360------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
T
S
S
Y
R
Q
Q
L
Q
A
K
I
D
R
I
T
T
Q
F
SEF-TP
P
T
L
E
V
FES
P
E
Q
H
F
R
M
R
A
E
F
R
I
W
HTE--N
D
M
F
Y
A
M
F
ERNDDGK
Q
K
T
V
V
R
IDE---FPIADK
S
I
N
D
L
M
P
L
L
L
A
E
L
K
A
----
N
S
L
L
S
Q
R
L
F
--
E
V
D
----
F
L
A
TLSG
E
M
L
V
T
L
I
Y
H
R
K
L
N
Q
E
W
E
Q
A
A
K
A
L
-----
A
E
--KL-----
N
-----
I
---
K
-
I
M
GRSRG
Q
K
I
V
IG
D
D
----
F
V
V
E
E
F
E
L
L
N
R
SF
K
Y
K
Q
I
E
S
S--FTQP
N
A
Q
V
C
K
K
M
L
Q
WACDAAE-G-SK
K
H
L
L
E
L
Y
CGNG
N
F
T
L
P
L
S
L
K
--
F
-
E
-
R
V
L
A
T
E
L
A
KSS
V
Y
A
A
Q
W
NIEQNQ--I-D-
N
-
I
Q
V
A
RL
S
A
E
E
F
T
Q
A
YQG
E
R
E
F
R
R
L
Q
E
ADI
D
I
QSY---DF
G
T
V
F
VDPPR---------------A--G---I
D
--
D
-----------
E
-
T
L
K
L
-----
L
--
Q
---GF-E--
R
I
I
Y
------
I
SC----
N
P
--
D
T
---
L
---
Y
-
E
N
L
K
T
----
L
T
--------
Q
--
T
--HR
V
T
K
------
F
A
L
---FDQ-----F-PYTHHVESG
V
L
LEKI-------------------------
10
PsiBlast_CBE
90.70
50%
-35
- C1 -
-
3BT7
1
TRMA_ECOLI
B:
[11-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
F
-
S
D
L
V
P
E
V
F
R
S
P
V
S
H
Y
R
M
R
A
E
F
R
I
W
H
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G
--
D
D
L
Y
H
I
I
F
----
D
Q
Q
T
K
S
R
I
R
V
D
S
---
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
----
N
P
V
L
R
H
K
L
F
--
Q
I
D
----
Y
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
K
L
D
D
E
W
R
Q
E
A
E
A
L
RDALR
A
Q
--
N
L
-----
N
-----
V
---
H
-
L
I
G
R
A
T
K
T
K
I
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L
D
Q
D
----
Y
I
D
E
R
L
P
V
A
G
K
E
M
I
Y
R
Q
V
E
N
S
--
F
T
Q
P
N
A
A
M
N
I
Q
M
L
E
W
A
L
D
V
T
K
-
G
-
S
K
G
D
L
L
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L
Y
C
G
N
G
N
F
S
L
A
L
A
R
N
--
F
-
D
-
R
V
L
A
T
E
I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
N
H
--
I
-
D
-
N
-
V
Q
I
I
R
M
A
A
E
E
F
T
Q
A
M
N
G
V
R
E
F
N
R
L
Q
--
G
I
D
L
K
S
Y
---
Q
C
E
T
I
F
V
D
P
P
R
---------------
S
--
G
---
L
D
--
S
-----------
E
-
T
E
K
M
-----
V
--
Q
---
A
Y
-
P
--
R
I
L
Y
------
I
S
C
----
N
P
--
E
T
---
L
---
C
-
K
N
L
E
T
----
L
S
--------
Q
--
T
--
H
K
V
E
R
------
L
A
L
---
F
D
Q
-----
F
-
P
Y
T
H
H
M
Q
C
G
V
L
L
----------------------------
1
PsiBlast_PDB
90.69
50%
-34
- C1 -
-
3BT7
1
TRMA_ECOLI
A:
[11-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
F
-
S
D
L
V
P
E
V
F
R
S
P
V
S
H
Y
R
M
R
A
E
F
R
I
W
H
D
G
--
D
D
L
Y
H
I
I
F
----
D
Q
Q
T
K
S
R
I
R
V
D
S
---
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
----
N
P
V
L
R
H
K
L
F
--
Q
I
D
----
Y
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
K
L
D
D
E
W
R
Q
E
A
E
A
L
R
D
A
L
R
A
Q
--
N
L
-----
N
-----
V
---
H
-
L
I
G
R
A
T
K
T
K
I
E
L
D
Q
D
----
Y
I
D
E
R
L
P
V
A
G
K
E
M
I
Y
R
Q
V
E
N
S
--
F
T
Q
P
N
A
A
M
N
I
Q
M
L
E
W
A
L
D
V
T
K
-
G
-
S
K
G
D
L
L
E
L
Y
C
G
N
G
N
F
S
L
A
L
A
R
N
--
F
-
D
-
R
V
L
A
T
E
I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
N
H
--
I
-
D
-
N
-
V
Q
I
I
R
M
A
A
E
E
F
T
Q
A
M
N
G
V
R
E
F
N
R
L
Q
--
G
I
D
L
K
S
Y
---
Q
C
E
T
I
F
V
D
P
P
R
---------------
S
--
G
---
L
D
--
S
-----------
E
-
T
E
K
M
-----
V
--
Q
---
A
Y
-
P
--
R
I
L
Y
------
I
S
C
----
N
P
--
E
T
---
L
---
C
-
K
N
L
E
T
----
L
S
--------
Q
--
T
--
H
K
V
E
R
------
L
A
L
---
F
D
Q
-----
F
-
P
Y
T
H
H
M
Q
C
G
V
L
L
----------------------------
11
HHSearch
82.55
51%
18
- C1 -
-
3BT7
1
TRMA_ECOLI
A:
[10-369]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
E
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
F
S
D
L
-
V
P
E
V
F
R
S
P
V
S
H
Y
R
M
R
A
E
F
R
I
W
H
D
G
--
D
D
L
Y
H
I
I
F
D
Q
Q
T
K
----
S
R
I
R
V
D
S
---
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
----
N
P
V
L
R
H
K
L
F
--
Q
I
D
----
Y
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
K
L
D
D
E
W
R
Q
E
A
E
A
L
-----
R
D
--
A
L
-----
R
A
Q
NLN
V
---
H
-
L
I
G
R
A
T
K
T
K
I
E
L
D
Q
D
----
Y
I
D
E
R
L
P
V
A
G
K
E
M
I
Y
R
Q
V
E
N
S
--
F
T
Q
P
N
A
A
M
N
I
Q
M
L
E
W
A
L
D
V
T
K
-
G
-
S
K
G
D
L
L
E
L
Y
C
G
N
G
N
F
S
L
A
L
A
R
N
--
F
-
D
-
R
V
L
A
T
E
I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
N
H
--
I
-
D
-
N
-
V
Q
I
I
R
M
A
A
E
E
F
T
Q
A
M
N
G
V
R
E
F
N
R
L
Q
--
G
I
D
L
K
S
Y
---
Q
C
E
T
I
F
V
D
P
P
R
---------------
S
--
G
---
L
D
--
S
-----------
E
-
T
E
K
M
-----
V
--
Q
---
A
Y
-
P
--
R
I
L
Y
------
I
S
C
----
N
P
--
E
T
---
L
---
C
-
K
N
L
E
T
----
L
S
--------
Q
--
T
--
H
K
V
E
R
------
L
A
L
---
F
D
Q
-----
F
-
P
Y
T
H
H
M
Q
C
G
V
L
L
T
A
K
-------------------------
36
Fugue
81.59
51%
30
- C1 -
-
3BT7
1
TRMA_ECOLI
A:
[1-369]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G
S
H
M
T
P
EHL
P
T
E
Q
Y
E
A
Q
L
A
E
K
V
V
R
L
Q
S
M
M
A
P
F
-
S
D
L
V
P
E
V
F
R
S
P
V
S
H
Y
R
M
R
A
E
F
R
I
W
H
D
G
--
D
D
L
Y
H
I
I
F
D
Q
Q
T
----
K
S
R
I
R
V
D
S
---
F
P
A
A
S
E
L
I
N
Q
L
M
T
A
M
I
A
G
V
R
N
----
N
P
V
L
R
H
K
L
F
--
Q
I
D
----
Y
L
T
T
L
S
N
Q
A
V
V
S
L
L
Y
H
K
K
L
D
D
E
W
R
Q
E
A
E
A
L
-----
R
D
--
A
L
R
A
Q
NL
N
-----
V
---
H
-
L
I
G
R
A
T
K
T
K
I
E
L
D
Q
D
----
Y
I
D
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L
P
V
A
G
K
E
M
I
Y
R
Q
V
E
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S
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F
T
Q
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N
A
A
M
N
I
Q
M
L
E
W
A
L
D
V
T
K
-
G
-
S
K
G
D
L
L
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L
Y
C
G
N
G
N
F
S
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A
L
A
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N
--
F
-
D
-
R
V
L
A
T
E
I
A
K
P
S
V
A
A
A
Q
Y
N
I
A
A
N
H
--
I
-
D
-
N
-
V
Q
I
I
R
M
A
A
E
E
F
T
Q
A
M
N
G
V
R
E
F
N
R
L
Q
G
--
I
D
L
K
S
Y
---
Q
C
E
T
I
F
V
D
P
P
R
---------------
S
--
G
---
L
D
--
S
-----------
E
-
T
E
K
M
-----
V
--
Q
---
A
Y
-
P
--
R
I
L
Y
------
I
S
C
----
N
P
--
E
T
---
L
---
C
-
K
N
L
E
T
----
L
S
--------
Q
--
T
--
H
K
V
E
R
------
L
A
L
---
F
D
Q
-----
F
-
P
Y
T
H
H
M
Q
C
G
V
L
L
T
A
K
-------------------------
12
HHSearch
60.24
24%
4
* C1 *
-
1UWV
1
RLMD_ECOLI
A:
[93-431]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
A
S
V
D
L
Q
Q
R
S
K
S
A
A
L
A
R
L
M
K
H
D
----
V
S
E
V
I
A
D
V
P
W
G
Y
R
R
R
A
R
L
S
L
N
Y
L
P
KT
Q
Q
L
Q
M
G
F
R
K
A
G
S
S
----
D
I
V
D
V
K
Q
---
C
P
I
L
A
P
Q
L
E
A
L
L
P
K
V
R
A
C
L
G
S
----
L
Q
A
M
-
R
H
L
G
--
H
V
E
----
L
V
Q
A
T
S
G
T
L
M
I
L
R
H
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A
P
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L
S
S
A
D
R
E
K
L
E
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F
-----
S
H
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L
-----
D
-----
L
---
Y
-
L
A
P
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----
P
W
-
Y
D
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N
----
G
L
R
L
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D
--
F
I
Q
V
N
A
G
V
N
Q
K
M
V
A
R
A
L
E
W
L
D
-
V
Q
P
E
D
R
V
L
D
L
F
C
G
M
G
N
F
T
L
P
L
A
T
Q
--
A
-
A
-
S
V
V
G
V
E
G
V
P
A
L
V
E
K
G
Q
Q
N
A
R
L
N
G
--
L
-
Q
-
N
-
V
T
F
Y
H
E
N
L
E
E
D
V
T
K
Q
P
W
--------------
A
K
N
---
G
F
D
K
V
L
L
D
P
A
R
---------------
A
--
G
---
A
A
--
G
-------------
V
M
Q
Q
-----
I
--
I
K
L
-
E
P
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I
--
R
I
V
Y
------
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S
C
----
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---
A
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D
S
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A
----
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L
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-------
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T
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A
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------
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A
M
---
L
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-----
F
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P
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T
G
H
L
E
S
M
V
L
F
S
R
--------------------------
5
PsiBlast_PDB
58.23
28%
-77
- C1 -
-
2JJQ
2
ATRMA_PYRAB
A:
[268-419]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
--
F
F
Q
T
N
S
Y
Q
A
V
N
L
V
R
K
V
S
E
L
V
E
-
G
-
E
K
--
I
L
D
M
Y
S
G
V
G
T
F
G
I
Y
L
A
K
R
--
G
-
F
-
N
V
K
G
F
D
S
N
E
F
A
I
E
M
A
R
R
N
V
E
I
N
N
--
V
-
D
-
A
--------------------
E
F
E
V
A
S
D
R
E
V
S
V
K
G
F
---
D
--
T
V
I
V
D
P
P
R
---------------
A
--
G
---
L
H
--
P
-----------
R
-
L
V
K
R
-----
L
N
R
E
---
K
P
-
G
--
V
I
V
Y
------
V
S
C
----
N
P
--
E
T
---
F
---
A
-
R
D
V
K
M
----
L
------------
D
--
Y
R
I
D
E
------
I
V
A
---
L
D
M
-----
F
-
P
H
T
P
H
V
E
---------------------------------
2
PsiBlast_PDB
52.96
30%
-24
- C1 -
-
2BH2
1
RLMD_ECOLI
A:
[263-432]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
Q
V
N
A
G
V
N
Q
K
M
V
A
R
A
L
E
W
L
D
V
Q
-
P
E
D
R
V
L
D
L
F
C
G
M
G
N
F
T
L
P
L
A
T
Q
--
A
-
A
-
S
V
V
G
V
E
G
V
P
A
L
V
E
K
G
Q
Q
N
A
R
L
N
G
--
L
-
Q
-
N
-
V
T
F
Y
H
E
N
L
E
E
-----------------
D
V
T
K
Q
P
W
AKN
G
F
D
K
V
L
L
D
P
A
R
---------------
A
--
G
---
A
A
--
G
-----------
V
-
M
Q
Q
I
-----
I
--
K
----
L
-
E
PI
R
I
V
Y
------
V
S
C
----
N
P
--
A
T
---
L
---
A
-
R
D
S
E
A
----
L
L
--------
K
--
A
G-
Y
T
I
A
R
------
L
A
M
---
L
D
M
-----
F
-
P
H
T
G
H
L
E
S
M
V
L
F
S
R
V
-------------------------
3
PsiBlast_PDB
50.94
30%
-14
- C1 -
-
1UWV
-
RLMD_ECOLI
A:
[263-431]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
Q
V
N
A
G
V
N
Q
K
M
V
A
R
A
L
E
W
L
D
V
Q
-
P
E
D
R
V
L
D
L
F
C
G
M
G
N
F
T
L
P
L
A
T
Q
--
A
-
A
-
S
V
V
G
V
E
G
V
P
A
L
V
E
K
G
Q
Q
N
A
R
L
N
G
--
L
-
Q
-
N
-
V
T
F
Y
H
E
N
L
E
E
-----------------
D
V
T
K
Q
P
W
AKN
G
F
D
K
V
L
L
D
P
A
R
AGA------------
A
--
G
---
V
M
--
Q
-----------
Q
-
I
I
K
L
-----
E
--
P
------
I
--
R
I
V
Y
------
V
S
C
----
N
P
--
A
T
---
L
---
A
-
R
D
S
E
A
----
L
L
--------
K
--
A
G-
Y
T
I
A
R
------
L
A
M
---
L
D
M
-----
F
-
P
H
T
G
H
L
E
S
M
V
L
F
S
R
--------------------------
16
HHSearch
47.65
18%
-57
- C1 -
-
1WXX
-
?
C:
[177-378]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
G
R
V
R
Y
L
V
D
L
R
A
--
G
Q
K
T
G
A
Y
L
D
Q
R
E
N
R
L
Y
M
E
R
F
----
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
--
F
-
R
-
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
--
L
-
G
-
N
-
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
--------------
E
G
E
---
R
F
D
L
V
V
L
D
P
P
A
---------------
F
--
A
---
K
G
--
K
KDVERAYRAYK
E
-
V
N
L
R
-----
A
--
I
KLL
K
E
G
G
--
I
L
A
T
------
A
S
C
----
S
H
--
H
M
---
T
---
E
-
P
L
F
Y
A
----
M
V
AEAAQDAH
R
LL
R
--
V
V
E
K
R
------
G
Q
P
---
F
D
H
PVLLN
H
-
P
E
T
H
Y
L
K
F
A
V
------------------------------
28
HHSearch
43.27
17%
-27
- C1 -
-
3P9N
-
?
A:
[12-180]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
R
I
A
V
P
P
R
G
-----
T
T
D
R
V
R
E
S
L
F
N
I
V
T
A
R
R
D
-
L
-
T
G
L
A
V
L
D
L
Y
A
G
S
G
A
L
G
L
E
A
L
S
R
G-
A
-
A
-
S
V
L
F
V
E
S
D
Q
R
S
A
A
V
I
A
R
N
I
E
A
L
G
--
L
-
S
-
G
-
A
T
L
R
R
G
A
V
A
A
V
V
A
A
G
T
----------------
T
S
---
P
V
D
L
V
L
A
D
P
P
Y
---------------
N
--
V
---
D
S
--
A
D
V
D
--------
A
-
I
L
A
A
L
G
T
N
G
W
--
T
---
R
E
-
G
--
T
V
A
V
V
E
R
A
--
T
T
C
----
A
P
--
L
T
---
W
---
P
-
E
G
W
R
R
----
W
P
Q
-------
R
--
V
--
Y
G
D
T
R
------
L
E
------------------------------------------------------
41
Fugue
41.72
16%
-26
- C1 -
-
3A25
-
TYW2_PYRHO
A:
[29-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
P
R
I
R
E
I
L
S
K
E
L
---------------------------------------------------------
P
E
E
L
V
K
L
---
L
P
K
R
W
V
R
I
G
D
------------------------------------------
V
L
L
L
P
L
R
P
E
L
E
P
Y
K
H
R
I
A
E
V
Y
-----
A
E
--
V
L
-----
G
-----
V
---
K
-
T
V
L
R
K
G
D
Y
E
L
L
Y
G
S
D
----
T
V
T
V
H
V
E
N
-
G
I
K
Y
K
L
D
V
A
K
I
M
--
F
S
P
A
N
V
K
E
R
V
R
M
A
K
V
A
------
K
-
P
D
E
L
V
V
D
M
F
A
G
I
G
H
L
S
L
P
I
A
V
Y
--
G
-
K
A
K
V
I
A
I
E
K
D
P
Y
T
F
K
F
L
V
E
N
I
H
L
N
K
--
V
-
E
-
D
R
M
S
A
Y
N
M
D
N
R
D
F
P
G
E
N
I
A
D
R
I
L
M
G
Y
V
V
-----
R
T
H
---
E
F
I
P
K
A
L
S
I
A
K
---------------
D
--
G
-------------------
A
-
I
I
H
Y
-----
H
--
N
---
T
V
-
P
--
E
K
L
M
------
P
R
E
----
P
F
--
E
T
---
F
---
K
-
R
I
T
K
E
----
Y
G
--------
Y
--
D
--
V
E
K
L
N
------
E
L
K
---
I
K
R
-----
Y
A
P
G
V
W
H
V
V
L
D
L
R
V
F
K
S
-------------------------
38
Fugue
41.42
15%
-12
- C1 -
-
2CWW
3
?
A:
[1-382]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
I
Q
V
N
A
K
G
A
A
R
L
L
S
-----------
R
H
L
W
V
F
R
R
D
V
V
S
G
P
E
T
P
G
L
Y
P
V
Y
W
G
--
R
R
F
L
A
L
A
L
Y
N
P
H
T
D
L
A
V
R
A
Y
R
F
A
P
---
A
E
D
P
V
A
A
L
L
E
N
L
A
Q
A
L
A
R
R
E
A
V
L
R
Q
D
P
E
G
G
Y
R
L
V
HA
E
G
D
LLPG
L
V
V
D
Y
Y
A
G
H
A
V
V
Q
A
T
A
H
A
W
E
G
L
L
P
Q
V
A
E
A
L
-----
R
P
--
H
V
-----
Q
-----
S
---
V
-
L
A
K
N
D
A
R
T
R
E
L
E
G
L
P
----
L
Y
V
R
P
L
L
G
E
V
P
E
R
V
Q
V
Q
E
G
R
V
--
R
Y
L
V
D
L
G
A
Y
L
D
Q
R
E
N
R
L
Y
M
E
R
-
F
-
R
G
E
R
A
L
D
V
F
S
Y
A
G
G
F
A
L
H
L
A
L
G
--
F
-
R
-
E
V
V
A
V
D
S
S
A
E
A
L
R
R
A
E
E
N
A
R
L
N
G
--
L
-
G
-
N
-
V
R
V
L
E
A
N
A
F
D
L
L
R
R
L
E
K
E
G
E
-----------------
R
F
D
L
V
V
L
D
P
P
A
FAKGKKD
V
E
R
A
Y
R
A
Y
K
--
E
---
V
N
--
L
-----------
R
-
A
I
K
L
-----
L
--
K
---
E
G
-
G
--
I
L
A
T
------
A
S
C
SHHM
T
E
--
P
L
---
F
---
Y
-
A
M
V
A
E
----
A
A
--------
Q
--
D
A
H
R
L
L
R
V
------
V
E
K
---
R
G
Q
PFD--
H
-
P
V
L
L
N
H
P
E
T
H
Y
L
K
F
A
V
F
Q
V
L--------------------
42
Fugue
41.26
13%
-7
- C1 -
-
2B78
-
?
A:
[1-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
--
S
F
A
E
K
K
L
K
R
G
V
Q
L
L
-
S
S
R
D
Y
P
N
L
N
L
D
N
Q
V
V
Q
L
Y
S
D
-----
A
D
--
I
F
L
G
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
P
K
K
V
SLN
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
H
S
----
K
L
T
T
A
Y
R
L
F
NQ
D
G
D
SFGG
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
S
F
V
Y
Q
I
R
D
E
I
V
A
A
F
-----
R
Q
--
V
Y
-----
P
NFL
G
-
A
---
Y
-
E
K
I
R
F
N
V
S
A
H
L
Y
G
Q
E
-----
A
P
E
Q
F
L
I
L
E
N
G
I
S
Y
N
V
F
L
N
D
--
G
L
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
-
A
-
A
G
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G-
A
-
M
-
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
--
L
-
D
-
M
-
A
N
H
Q
L
V
V
M
D
V
F
D
Y
F
K
Y
A
R
R
H
H
L
T
Y
D
I
I
I
I
D
P
P
S
F
---
E
V
F
S
--
V
S
K
D
Y
---------------
H
--
K
---
L
I
--
R
-----------
Q
-
G
L
E
I
-----
L
--
S
---
E
N
-
G
--
L
I
I
A
------
S
T
N
AANM
T
V
--
S
Q
---
F
---
K
-
K
Q
I
E
K
----
G
F
--------
G
--
K
--
Q
K
H
T
Y
------
L
D
L
---
Q
Q
L
PSD--
F
-
A
V
N
V
Q
D
E
S
S
N
Y
L
K
V
F
T
I
K
V---------------------
17
HHSearch
39.08
17%
-25
- C1 -
-
5HJM
2
TAW22_PYRAB
A:
[156-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
V
I
W
G
E
N
----
R
L
H
T
I
H
--
K
E
N
G
V
L
I
K
V
D
L
S
K
--
V
F
-
F
N
P
R
M
K
G
E
R
Y
R
-
I
A
Q
L
V
N
---
D
G
E
R
I
L
V
P
F
A
G
V
I
P
Y
P
L
V
I
A
R
F
K
-
N
-
V
-
E
V
Y
A
V
E
I
N
E
F
A
V
K
L
A
E
E
N
L
E
L
N
R
DR
L
-
K
G
K
-
I
K
I
I
H
G
D
V
F
E
V
L
P
N
L
------------------
P
---
N
F
D
R
V
V
S
P
T
P
K
---------------
G
------
V
D
--
A
-----------
L
-
S
L
T
L
-----
S
--
K
---
A
E
-
K
--
F
L
H
Y
------
Y
D
F
----
V
H
--
E
S
---
E
---
I
-
E
R
F
R
E
R
V
L
E
E
C
R
R
Q
G----
K
--
E
--
C
R
V
S
V
------
R
K
V
---
S
D
Y
-----
K
-
P
H
V
Y
K
V
C
A
--------------------------------
44
Fugue
38.46
13%
4
- C1 -
-
3LDF
1
?
A:
[1-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
M
V
G
--
S
F
A
E
K
K
L
K
R
G
V
Q
L
L
-
S
S
R
D
Y
P
N
L
N
L
D
N
Q
V
V
Q
L
Y
S
D
A
D
I
F
L
G
-------
T
A
Y
L
S
K
Q
N
K
G
V
G
W
L
I
S
P
K
K
V
S
L
N
V
T
Y
F
I
K
L
F
Q
W
S
K
D
K
R
K
N
F
A
H
S
----
K
L
T
T
A
Y
R
L
F
N
Q
D
G
D
SFGG
V
T
I
D
C
Y
G
D
F
V
L
F
S
W
Y
N
S
F
V
Y
Q
I
R
D
E
I
V
A
A
F
-----
R
Q
--
V
Y
PNFL-
G
-----
A
---
Y
-
E
K
I
R
F
N
V
S
A
H
L
Y
G
Q
E
APE
Q
F
L
I
L
E
N
---
G
I
S
Y
N
V
F
L
N
D
G
L
--
M
T
G
I
F
L
D
Q
R
Q
V
R
N
E
L
I
N
G
S
A
A
-
G
---
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G-
A
-
M
-
A
T
T
S
V
D
L
A
K
R
S
R
A
L
S
L
A
H
F
E
A
N
H
--
L
-
D
-
M
-
A
N
----------
H
Q
L
V
V
M
D
V
F
D
Y
F
K
Y
A
R
R
H
H
L
T
Y
---
D
I
--
I
I
I
D
P
P
S
---------------
F
--
A
---
R
N
--
K
-----------
E
-
V
F
S
V
-----
S
--
K
---
D
Y
-
H
--
K
L
I
R
------
Q
G
L
----
E
I
--
L
S
---
E
---
N
-
G
L
I
I
A
----
S
T
--------
N
--
A
--
A
N
M
T
V
------
S
Q
F
---
K
K
Q
-----
I
-
E
K
G
F
G
K
Q
K
H
T
Y
L
D
L
Q
Q
L
PSDFAVNVQDESSNY
L
K
V
F
T
I
K
V
20
HHSearch
35.31
19%
10
- C1 -
-
3A27
-
TYW2_METJA
A:
[90-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
C
L
F
K
L
D
V
A
K
I
M
W
S
Q
G
N
I
E
E
R
K
R
M
A
F
I
S
----
N
---
E
N
E
V
V
V
D
M
F
A
G
I
G
Y
F
T
I
P
L
A
K
Y
SK
P
-
K
-
L
V
Y
A
I
E
K
N
P
T
A
Y
H
Y
L
C
E
N
I
K
L
N
K
--
L
-
N
-
N
-
V
I
P
I
L
A
D
N
R
D
V
E
L
--
K
-----------------
D
---
V
A
D
R
V
I
M
G
Y
V
H
---------------
K
TH
K
---
F
L
--
D
-----------
K
-
T
F
E
F
-----
L
------
K
D
-
R
--
G
V
I
H
------
Y
H
E
----
T
V
--
A
E
KIM
Y
E
R
P
I
-
E
R
L
K
F
----
Y
A
E
K
------
N
--
G
--
Y
K
L
I
D
------
Y
E
V
R
K
I
K
K
Y
-----
A
-
P
G
V
W
H
V
V
V
D
A
K
F
E
R
I
-------------------------
26
HHSearch
35.15
17%
-11
- C1 -
-
1WY7
1
?
C:
[50-195]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
V
V
A
D
L
G
A
G
T
G
V
L
S
Y
G
A
L
L
L
--
G
A
K
-
E
V
I
C
V
E
V
D
K
E
A
V
D
V
L
I
E
N
L
G
E
F
K
----
G
-
K
-
F
K
V
F
I
G
D
V
S
E
F
----
N
-----------------
S
---
R
V
D
I
V
I
M
N
P
P
F
---------------
G
--
S
---
Q
R
--
K
-----------
H
A
D
R
P
F
-----
L
--
L
K
A
F
E
I
-
S
--
D
V
V
Y
------
S
I
H
----
L
A
--
K
P
---
E
---
V
R
R
F
I
E
K
----
F
S
W
E
------
H
--
G
--
F
V
V
T
H
R
L
T
T
K
I
E
I
P
---------------
R
K
K
L
E
R
I
T
V
-----------------------------
6
PsiBlast_PDB
35.11
33%
-56
- C1 -
-
3GGD
3
?
A:
[60-118]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
F
A
C
G
N
G
T
Q
T
K
F
L
S
Q
F
--
F
-
P
-
R
V
I
G
L
D
V
S
K
S
A
L
E
I
A
A
---
K
E
N
T
--
A
-
A
-
N
-
I
S
Y
R
L
L
D
G
L
V
P
E
Q
A
A
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
34.63
16%
23
- C1 -
-
3V97
6
RLMKL_ECOLI
A:
[1-703]
A
M
N
S
L
F
A
S
T
A
RGL
E
E
L
L
K
T
E
L
E
N
L
GAVE
C
Q
V
V
QG
G
V
H
F
K
G
D
T
R
L
V
Y
Q
S
L
M
W
SRLAS
R
I
M
L
P
L
G
E
C
K
V
YS
D
L
D
L
Y
L
G
V
Q
AINWTEMFNPG
A
T
F
A
V
H
F
S
G
L
N
DTIRN
S
Q
Y
G
A
M
K
V
K
D
A
I
V
D
A
F
T
R
K
NLP
R
P
N
V
D
RDAPD
I
R
V
N
V
W
L
H
KE
T
A
S
I
A
L
D
LSGDGLHLRGYRDRAGIAPIK
E
T
L
A
A
A
I
V
M
R
SGWQPG
T
P
L
L
D
PMCGSG
T
L
L
I
E
A
A
M
L
A
T
DRAPGLHRGRWGFSGWAQHD
E
A
I
W
Q
E
V
K
A
E
A
Q
T
R
A
R
K
G
L
A
E
YS
S
H
F
Y
G
S
D
SD
A
R
V
I
Q
R
A
R
T
N
A
R
L
A
GIGEL
I
T
F
E
VKDVAQLTNPLPKGP
Y
G
T
V
L
S
N
P
P
Y
GESE
P
A
L
I
A
L
H
S
L
L
G
R
I
M
K
N
QFGG
W
N
L
S
L
F
S
A
S
P
D
L
L
S
C
L
Q
L
R
A
D
K
Q
Y
K
A
K
-
N
G
P
----
L
D
C
V
Q
K
N
Y
H
V
A
E
S
M
V
A
E
D
Y
T
--
N
R
L
R
K
N
L
K
K
F
E
K
W
A
R
Q
E
G
I
-----------------
E
C
Y
R
L
Y
D
A
D
L
P
E
----
Y
N
V
A
V
D
R
Y
----------------
A
D
W
V
V
V
Q
E
Y
A
H
K
A
R
Q
R
L
F
D
I
I
A
A
T
-----
I
S
--
V
L
-----
G
-----
I
APN
K
-
L
V
L
K
T
R
E
E
K
---
G
E
F
----
L
E
V
T
E
Y
N
A
H
L
W
V
N
L
T
D
Y
L
D
T
G
--
L
F
L
D
H
R
I
A
R
R
M
L
G
Q
M
S
--------
K
G
K
D
F
L
N
L
F
S
Y
T
G
S
A
T
V
H
A
G
L
G
G-
A
-
R
-
S
T
T
T
V
D
M
S
R
T
Y
L
E
W
A
E
R
N
L
R
L
N
G
--
L
-
T
-
G
----------------
R
A
H
R
L
I
Q
A
D
C
L
A
W
L
R
E
A
N
E
---
Q
F
D
L
I
F
I
D
P
P
T
---------------
F
--
S
AFD
V
Q
--
R
-----------
D
-
H
L
A
L
-----
M
--
K
---
D
L
-
K
--
R
L
L
R
AG
G
T
I
M
F
S
N
----
N
K
--
R
G
---
F
---
R
-
M
D
L
D
G
----
L
A
K
L
G
L
----
K
--
A
--
Q
E
I
T
Q
------
K
T
L
---
S
Q
D
-----
F
-
A
R
N
R
Q
I
H
N
C
W
L
I
T
A
A
-------------------------
45
Fugue
34.59
11%
46
- C1 -
-
3AY0
1
TRM5B_METJA
A:
[2-336]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P
L
C
L
K
I
N
K
K
H
G
E
Q
T
R
R
I
L
I
E
N
N
L
L
-
N
K
D
Y
K
I
T
S
E
G
N
Y
L
Y
L
P
I
K
D
----------------
V
D
E
D
I
L
K
S
I
L
N
I
E
F
E
L
V
D
---
K
E
L
E
E
K
S
F
R
E
I
I
S
K
K
Y
R
K
E
I
D
----
E
G
L
I
S
L
S
Y
D
--
V
V
G
----
D
L
V
I
L
Q
-------
I
S
D
E
V
D
E
K
I
R
K
E
I
G
E
L
A
-----
Y
K
--
L
I
-----
P
-----
C
---
K
G
V
F
R
R
V
R
E
L
E
H
L
A
G
E
N
----
R
T
L
T
I
H
K
E
N
G
Y
R
L
W
V
D
I
A
K
V
Y
--
F
S
P
R
L
G
G
E
R
A
R
I
M
K
K
V
------
S
-
L
N
D
V
V
V
D
M
F
A
G
V
G
P
F
S
I
A
C
K
-
N
--
A
-
K
-
K
I
Y
A
I
D
I
N
P
H
A
I
E
L
L
K
K
N
I
K
L
N
K
--
L
E
H
-
K
-
I
I
P
I
L
S
D
V
R
E
V
D
V
------------------------
K
G
N
R
V
I
M
N
L
P
K
---------------
F
--
A
---
H
K
F
I
D
-----------
K
-
A
L
D
I
-----
V
--
E
---
E
G
-
G
--
V
I
H
Y
------
Y
T
I
----
G
K
DF
D
K
---
A
---
I
-
K
L
F
E
K
----
K
C
--------
D
--
C
--
E
V
L
E
K
------
R
I
V
---
K
S
Y
-----
A
-
P
R
E
Y
I
L
A
L
D
F
K
I
N
K
K
-------------------------