@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR65: (2017-12-01 )
MADFKAKEILLNAFDMNCVGHINHGLWTHPRDESHRFNELSYWTEQAKTLENGLFDGLFIADITGVYDVYQNGIDLTLKESIQLPSHDPSTLISAMAAVTQNLSFGVTVNLSYEHPYQFARRFASLDHLTQGRIGWNIVTGYLDSAERLIGQKGLKDHDARYEQAEEFLELCYKYWEGSWENDAVKKDKARRVFTDPSKVHTIHHHGKYYQSEGVFQVSPSVQRTPTLFQAGASPKGMQFATRHAECVFIGGDKPEKIREQVKKIRTLAEQQGRSANDIKVFVGITVVVAETHDLAVQKLNEYRQYASPEAGLAHYASSTGIDLSKFADDEAIPYQKSNSIVSITEKFKEQQITKNDLKAQHVLGGRYPLIVGSGEEVAEYLIHLLDETDIDGFNLTRTVAPESHHDFIRLVIPELQQHGRYKTAYKTGSLRNKIFNRGDHLPEQHPVQAFRCSPYNNSKNLTKIEEITA
Atome Classification :
(20 SA)
.........10........20.....------...30........40........50........60........70-......-...80..-......90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.....-..200.......210...-....220.-......230........240.......-250.......260.......270.......280.......290.......300.......-310.......-.320........330--..-------..---...---.-------.340---------.....-.----.-.----350....----...360--.----.....-------.--370.......380.......390.......400.......410.......420.......430.......-440........450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MADF
K
A
K
E
I
L
L
N
AFDMN
C
V
GHINHGL------WTHPRDESHRF
N
E
L
S
Y
W
T
E
Q
A
K
T
L
E
NGLFD
G
L
F
I
A
D
I
T
G
V
Y
D
V
Y
--QNGI
D
L
-
T
L
K
E
SIQ-LPSH
D
P
S
T
L
I
S
A
M
A
A
V
T
QNL
S
F
G
V
T
V
N
L
SYE
H
P
Y
Q
F
A
R
R
F
A
S
L
D
H
L
TQGRIG
W
N
I
V
T
G
Y
L
D
S
A
E
R
L
I
G
QKGLK
D
H
D
A
R
Y
E
Q
A
E
E
F
L
E
L
C
Y
K
Y
WEGSWENDA
V
K
K
D
K
ARRVFTDP-S
K
V
H
T
I
HHH
G
K
Y
YQSEG
V
-
F
Q
VSPSVQ-RT
P
T
L
F
QA-GASPKG
M
Q
F
ATRH
A
E
C
V
F
-IGGD
K
P
E
K
I
R
E
Q
V
K
K
I
R
T
L
A
E
QQGRSAN
D
I
K
V
F
V
G
I
T
V
V
V
AET
H
D
L
A
V
Q
K
L
N
E
Y
R
Q
YASP-E-A
G
L
A
H
YAS-ST-GI
D
L
S
KFADD----EA-------IP---YQK---S-------N
S
I
----------
V
S
I
T
E
-
K
----
F
-
K
----
E
QQI
T
K
N
----
D
L
K
A
Q
H--V----LGGRY-------
P
--
L
I
VG
S
G
E
E
V
A
E
Y
L
I
H
L
LDETDIDGFN
L
T
R
TVAPESH
H
D
F
I
R
L
V
I
P
E
L
Q
QHGR
Y
K
T
A
YKTG
S
L
R
N
K
I
FNRG-DH-LPEQHPV
Q
A
F
R
CSPYNNSKNL
T
K
I
E
E
ITA
2
PsiBlast_PDB
98.00
47%
-79
- C4 -
-
3B9O
1
?
A:
[3-434]
------
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
G
L
------
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
V
G
I
Y
D
V
Y
--
R
Q
S
R
D
T
-
A
V
R
E
A
V
Q
-
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
T
T
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
N
F
G
I
K
K
I
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
-
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
-
L
G
G
K
D
V
E
T
L
K
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
-
E
-
G
H
L
A
H
Y
G
G
-
G
T
-
G
Y
D
L
S
K
Y
S
S
N
----
D
Y
-------
I
G
---
S
I
S
---
V
-------
G
E
I
----------
I
N
N
M
S
-
K
----
L
-
D
-----------------------------
G
K
W
F
-------
K
--
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
G
I
D
G
F
N
L
V
Q
Y
V
S
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
K
L
F
G
K
G
-
N
Y
R
L
P
D
D
H
I
A
A
R
Y
R
------------------
21
PsiBlast_CBE
97.68
47%
-80
- C4 -
-
3B9O
1
?
B:
[3-434]
------
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
G
L
------
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
V
G
I
Y
D
V
Y
--
R
Q
S
R
D
T
-
A
V
R
E
A
V
Q
-
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
T
T
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
N
F
G
I
K
K
I
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
-
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
-
L
G
G
K
D
V
E
T
L
K
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
-
E
-
G
H
L
A
H
Y
G
G
-
G
T
-
G
Y
D
L
S
K
Y
S
S
N
----
D
Y
-------
I
G
---
S
I
S
---
V
-------
G
E
I
----------
I
N
N
M
S
-
K
----
L
-
D
-----------------------------
G
K
W
F
-------
K
--
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
G
I
D
G
F
N
L
V
Q
Y
V
S
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
K
L
F
G
K
G
-
N
Y
R
L
P
D
D
H
I
A
A
R
Y
R
------------------
1
PsiBlast_PDB
96.08
47%
-83
- C4 -
-
3B9N
-
?
A:
[3-434]
------
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
G
L
------
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
V
G
I
Y
D
V
Y
--
R
Q
S
R
D
T
-
A
V
R
E
A
V
Q
-
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
T
T
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
N
F
G
I
K
K
I
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
-
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
-
L
G
G
K
D
V
E
T
L
K
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
-
E
-
G
H
L
A
H
Y
G
G
-
G
T
-
G
Y
D
L
S
K
Y
S
S
N
----
D
Y
-------
I
G
---
S
I
S
---
V
-------
G
E
I
----------
I
N
N
M
S
-
K
----
L
-
D
-----------------------------
G
K
W
F
-------
K
--
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
G
I
D
G
F
N
L
V
Q
Y
V
S
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
K
L
F
G
K
G
-
N
Y
R
L
P
D
D
H
I
A
A
R
Y
R
------------------
23
HHSearch
93.76
48%
-50
- C4 -
-
3B9O
1
?
A:
[3-435]
------
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
G
L
------
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
V
G
I
Y
D
V
Y
--
R
Q
S
R
D
T
-
A
V
R
E
A
V
Q
-
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
T
T
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
N
F
G
I
K
K
I
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
-
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
-
L
G
G
K
D
V
E
T
L
K
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
-
E
-
G
H
L
A
H
Y
G
G
-
G
T
-
G
Y
D
L
S
K
Y
S
S
N
----
D
Y
-------
I
G
--------------------------------------------------
S
I
S
V
G
----
E
I
I
N
N
M
S
K
L
----
D
G
K
W
F
-------
K
--
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
G
I
D
G
F
N
L
V
Q
Y
V
S
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
K
L
F
G
K
G
N
Y
R
-
L
P
D
D
H
I
A
A
R
Y
R
N
-----------------
22
HHSearch
92.80
48%
-56
- C4 -
-
3B9N
-
?
B:
[1-434]
----
M
T
K
K
I
H
I
N
A
F
E
M
N
C
V
G
H
I
A
H
G
L
------
W
R
H
P
E
N
Q
R
H
R
Y
T
D
L
N
Y
W
T
E
L
A
Q
L
L
E
K
G
K
F
D
A
L
F
L
A
D
V
V
G
I
Y
D
V
Y
--
R
Q
S
R
D
T
-
A
V
R
E
A
V
Q
-
I
P
V
N
D
P
L
M
L
I
S
A
M
A
Y
V
T
K
H
L
A
F
A
V
T
F
S
T
T
Y
E
H
P
Y
G
H
A
R
R
M
S
T
L
D
H
L
T
K
G
R
I
A
W
N
V
V
T
S
H
L
P
S
A
D
K
N
F
G
I
K
K
I
L
E
H
D
E
R
Y
D
L
A
D
E
Y
L
E
V
C
Y
K
L
W
E
G
S
W
E
D
N
A
V
I
R
D
I
E
N
N
I
Y
T
D
P
-
S
K
V
H
E
I
N
H
S
G
K
Y
F
E
V
P
G
P
-
H
L
C
E
P
S
P
Q
-
R
T
P
V
I
Y
Q
A
-
G
M
S
E
R
G
R
E
F
A
A
K
H
A
E
C
V
F
-
L
G
G
K
D
V
E
T
L
K
F
F
V
D
D
I
R
K
R
A
K
K
Y
G
R
N
P
D
H
I
K
M
F
A
G
I
C
V
I
V
G
K
T
H
D
E
A
M
E
K
L
N
S
F
Q
K
Y
W
S
L
-
E
-
G
H
L
A
H
Y
G
G
-
G
T
-
G
Y
D
L
S
K
Y
S
S
N
----
D
Y
-------
I
G
--------------------------------------------------
S
I
S
V
G
----
E
I
I
N
N
M
S
K
L
----
D
G
K
W
F
-------
K
--
L
S
V
G
T
P
K
K
V
A
D
E
M
Q
Y
L
V
E
E
A
G
I
D
G
F
N
L
V
Q
Y
V
S
P
G
T
F
V
D
F
I
E
L
V
V
P
E
L
Q
K
R
G
L
Y
R
V
D
Y
E
E
G
T
Y
R
E
K
L
F
G
K
G
N
Y
R
-
L
P
D
D
H
I
A
A
R
Y
R
------------------
43
Fugue
75.79
31%
-75
- C4 -
-
1TVL
-
MOXC_BACSU
A:
[3-432]
----
R
A
D
F
I
Q
F
G
A
M
-
I
H
G
V
G
G
-
T
T
D
G
------
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
L
F
I
S
E
K
S
--
I
----------
P
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
T
S
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
N
H
S
K
S
N
L
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
-
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
-
T
H
S
N
S
L
E
E
T
K
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
-
E
-
N
A
V
T
---------------------------------------------------------------------
E
----
A
-
K
----
A
R
N
L
T
L
R
----
E
V
A
Q
E
M
--
A
------
F
P
R
-------
T
--
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
A
A
D
G
F
I
V
G
S
D
-
I
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
-
P
Q
------------------------------
24
HHSearch
75.56
30%
-48
- C4 -
-
3SDO
2
?
A:
[5-438]
---
M
T
R
K
H
I
H
F
G
V
L
I
Q
G
--
A
G
A
N
M
N
A
------
W
K
H
P
S
V
P
P
D
A
S
V
N
F
D
F
Y
V
D
R
A
R
R
A
E
N
A
G
I
A
F
A
F
I
A
D
S
A
Y
V
T
--
P
--
K
S
A
--------
P
H
F
-
L
N
R
F
E
P
I
S
L
L
S
A
L
A
V
L
T
S
K
I
G
L
V
G
T
M
S
S
S
Y
S
E
P
Y
N
V
A
R
Q
F
A
S
L
D
L
I
S
G
G
R
A
G
W
N
V
V
T
S
S
I
E
G
T
G
K
N
Y
G
R
P
H
-
P
D
H
A
Q
R
Y
A
I
A
A
E
H
L
D
V
V
Q
G
L
W
D
-
S
W
D
D
D
A
L
V
R
D
R
A
T
G
R
F
F
D
P
-
D
K
L
H
R
L
D
H
R
G
R
F
F
S
V
E
G
P
-
L
N
I
R
R
S
P
Q
-
G
Q
P
V
I
F
Q
A
-
G
S
S
D
D
G
I
D
L
A
G
R
S
A
D
A
V
F
-
S
N
G
S
T
F
D
E
A
R
V
F
Y
R
R
V
K
A
A
A
A
A
A
G
R
N
P
D
H
V
K
V
F
P
G
I
G
P
I
V
G
A
T
Q
Q
E
A
D
D
K
Y
R
Q
V
R
D
L
L
S
P
-
R
-
E
A
L
A
Y
L
S
H
-
F
F
Q
Q
H
D
F
S
V
Y
P
L
D
----
G
P
-------
F
P
---
D
I
G
TLG
S
-------
D
G
F
----------
Q
S
T
T
D
-
N
I
K
R
L
A
-
R
----
E
R
K
L
T
L
R
----
E
V
A
Y
E
V
--
S
T
R
R
S
N
I
G
T
S
-------
E
--
A
F
I
G
T
P
E
A
V
A
S
E
M
I
R
W
V
D
E
G
A
A
D
G
F
M
L
G
L
P
V
T
G
F
G
L
D
D
F
V
D
H
V
L
P
V
L
S
A
R
G
Y
F
D
P
V
R
R
G
A
T
L
R
D
H
L
G
L
P
----------------------------------
27
HHSearch
75.50
30%
-74
- C4 -
-
1TVL
-
MOXC_BACSU
A:
[3-430]
----
R
A
D
F
I
Q
F
G
A
M
I
H
G
V
--
G
G
T
T
D
G
------
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
L
F
I
S
E
K
S
--
I
----------
P
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
T
S
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
N
H
S
K
S
N
L
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
-
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
-
T
H
S
N
S
L
E
E
T
K
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
-
E
-
N
A
V
T
---------------------------------------------------------------------
E
----
A
-
K
----
A
R
N
L
T
L
R
----
E
V
A
Q
E
M
--------
A
F
P
R
-------
T
--
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
A
A
D
G
F
I
V
G
S
-
D
I
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
---------------------------------
3
PsiBlast_PDB
70.27
33%
5
- C4 -
-
5TLC
-
?
A:
[9-446]
---------
L
A
G
F
F
S
A
G
N
V
T
H
A
-
H
G
A
------
W
R
H
V
-
G
A
T
N
G
F
L
T
G
E
F
Y
K
Q
I
A
R
T
L
E
R
G
K
F
D
L
L
F
L
P
D
G
L
A
I
E
D
S
-NL
E
T
G
V
G
L
-
G
G
Q
G
A
V
A
-
L
---
E
P
T
S
V
I
A
T
M
A
A
V
T
Q
R
L
G
L
G
A
T
V
S
T
T
Y
Y
P
P
Y
H
V
A
R
V
F
A
T
L
D
N
L
S
D
G
R
I
S
W
N
V
V
T
S
L
N
D
S
E
A
R
N
F
G
V
D
E
H
L
E
H
D
I
R
Y
D
R
A
D
E
F
L
E
A
V
K
K
L
W
S
-
S
W
S
E
D
A
L
L
L
D
K
V
G
G
R
F
A
D
P
-
K
K
V
Q
Y
V
N
H
R
G
R
W
L
S
V
R
G
P
-
L
Q
V
P
R
S
R
Q
-
G
E
P
V
I
L
Q
A
-
G
L
S
P
R
G
R
R
F
A
G
R
W
A
E
A
V
F
-
S
V
S
P
N
L
D
I
M
R
A
V
Y
Q
D
I
K
A
H
V
A
A
A
G
R
D
P
E
Q
T
K
V
F
T
A
V
M
P
V
L
G
E
T
E
Q
V
A
R
E
R
L
E
Y
L
N
S
L
V
H
P
-
E
-
V
G
L
S
T
L
S
S
-
H
S
-
G
L
N
L
S
K
Y
P
L
D
TK
F
S
D
I
-------
V
A
---
D
L
G
---
D
-------
R
H
V
----------
P
T
M
L
Q
-
M
----
F
-
S
----
A
V
A
G
G
G
A
----
D
L
T
L
A
E
-------
L
G
R
R
Y
G
T
NVGF
V
P
--
Q
W
A
G
T
A
E
Q
I
A
D
Q
L
I
S
H
F
E
A
G
A
A
D
G
F
I
I
S
P
A
Y
L
P
G
I
Y
E
E
F
V
D
Q
V
V
P
L
L
Q
Q
R
G
V
F
R
T
E
Y
E
G
T
T
L
R
--------
E
H
-
L
G
L
A
H
------------------------
29
HHSearch
69.55
26%
-20
- C4 -
-
5DQP
1
?
A:
[4-426]
------
R
R
M
Y
L
V
S
W
L
N
S
--
S
G
V
L
P
N
S
------
W
N
E
G
R
G
N
R
A
R
I
F
D
L
E
N
Y
I
R
S
A
E
I
A
R
R
G
R
I
D
A
F
F
L
A
D
Q
P
Q
L
T
P
-
N
--
P
K
---------
V
R
P
-
E
Y
P
F
D
P
I
V
L
A
A
A
I
T
G
R
V
P
D
I
G
G
I
V
T
A
S
T
S
F
S
L
P
Y
T
L
A
R
Q
I
A
S
V
N
L
L
S
G
G
R
I
G
W
N
A
V
T
T
A
N
P
A
V
A
A
N
Y
G
A
A
I
-
A
T
H
D
N
R
Y
E
R
A
E
E
F
L
E
V
V
H
G
L
W
N
S
-
W
K
---
F
P
W
D
E
A
I
G
P
N
P
N
P
F
G
E
V
M
P
I
N
H
E
G
K
Y
F
K
V
A
G
P
-
L
N
V
P
L
P
P
Y
--
G
P
P
V
V
V
Q
A
G
G
S
D
Q
G
K
R
L
A
S
R
F
G
E
I
I
Y
-
A
F
L
G
S
K
P
A
G
R
R
F
V
A
E
A
R
A
A
A
R
A
Q
G
R
P
E
G
S
T
L
V
L
P
S
F
V
P
L
I
G
S
T
E
A
E
V
K
R
L
V
A
E
Y
E
A
G
L
D
P
-
A
E
Q
R
I
E
A
L
S
K
-
Q
L
-
G
I
D
L
E
R
I
N
V
D
----
Q
V
-------
L
Q
---
E
K
D
---
F
-------
N
L
P
KESATP
I
G
I
L
K
S
M
V
D
-
V
----
A
-
L
----
D
E
K
L
S
L
R
----
Q
L
A
------------
L
R
M
-------
R
--
L
I
A
G
T
P
D
Q
V
A
D
R
L
I
D
W
W
Q
D
E
A
A
D
G
F
V
I
N
A
P
L
L
P
D
A
L
E
I
F
V
D
Q
V
V
P
I
L
Q
S
R
G
V
F
P
R
S
Y
T
E
S
T
L
R
E
R
L
G
L
P
R
---------------------------------
5
PsiBlast_PDB
68.88
30%
-39
- C4 -
-
1YW1
2
MOXC_BACSU
A:
[13-431]
---------------
I
H
G
V
G
G
T
T
D
G
-------
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
--
G
L
F
-
I
S
--
E
K
S
I
P
H
-
F
L
N
R
-------
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
T
S
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
N
H
S
K
S
N
L
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
-
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
-
T
H
S
N
S
L
E
E
T
K
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
-
E
-
N
A
V
T
Y
L
A
------------------------------------------------------------------------------
R
E
A
K
A
R
N
----
L
T
L
R
E
V
--
A
----
Q
E
M
A
F
-------
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
A
A
D
G
F
I
V
G
S
D
I
-
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
---
N
L
G
-
L
G
-
I
P
---------------------------
28
HHSearch
68.59
30%
-34
- C4 -
-
1YW1
2
MOXC_BACSU
A:
[3-430]
----
R
A
D
F
I
Q
F
G
A
M
I
H
G
--
V
G
G
T
T
D
G
------
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
G
L
F
I
S
E
K
S
--
I
----------
P
H
F
-
L
N
R
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
T
S
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
N
H
S
K
S
N
L
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
-
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
-
T
H
S
N
S
L
E
E
T
K
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
-
E
-
N
A
V
T
Y
L
A
-------------------------------------------------------------------RE--
A
-
K
----
A
R
N
L
T
L
R
----
E
V
A
Q
E
M
--------
A
F
P
R
-------
T
--
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
A
A
D
G
F
I
V
G
S
-
D
I
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
N
L
G
L
G
I
---------------------------------
6
PsiBlast_PDB
68.46
30%
-2
- C4 -
-
3SDO
2
?
A:
[22-435]
----------------------
N
M
N
A
------
W
K
H
P
S
V
P
P
D
A
S
V
N
F
D
F
Y
V
D
R
A
R
R
A
E
N
A
G
I
A
F
A
F
I
A
D
S
A
Y
V
-------------
T
P
K
S
A
P
H
F
L
N
R
F
E
P
I
S
L
L
S
A
L
A
V
L
T
S
K
I
G
L
V
G
T
M
S
S
S
Y
S
E
P
Y
N
V
A
R
Q
F
A
S
L
D
L
I
S
G
G
R
A
G
W
N
V
V
T
S
S
I
E
G
T
G
K
N
Y
G
R
P
-
H
P
D
H
A
Q
R
Y
A
I
A
A
E
H
L
D
V
V
Q
G
L
W
D
-
S
W
D
D
D
A
L
V
R
D
R
A
T
G
R
F
F
D
P
-
D
K
L
H
R
L
D
H
R
G
R
F
F
S
V
E
G
P
-
L
N
I
R
R
S
P
Q
-
G
Q
P
V
I
F
Q
A
-
G
S
S
D
D
G
I
D
L
A
G
R
S
A
D
A
V
F
-
S
N
G
S
T
F
D
E
A
R
V
F
Y
R
R
V
K
A
A
A
A
A
A
G
R
N
P
D
H
V
K
V
F
P
G
I
G
P
I
V
G
A
T
Q
Q
E
A
D
D
K
Y
R
Q
V
R
D
L
L
S
P
-
R
-
E
A
L
A
Y
L
S
H
F
F
Q
-
Q
H
D
F
S
V
Y
P
L
D
----
G
P
-------
F
P
DIG
T
L
G
---
S
-------
D
G
F
----------
Q
S
T
T
D
-
N
----
I
-
K
R
L
A
R
E
R
K
L
T
L
R
E
V
A
Y
E
V
S
T
R
R
--
S
----
N
I
G
T
S
-------
E
--
A
F
I
G
T
P
E
A
V
A
S
E
M
I
R
W
V
D
E
G
A
A
D
G
F
M
L
G
L
P
V
T
G
F
G
L
D
D
F
V
D
H
V
L
P
V
L
S
A
R
G
Y
F
D
P
V
R
R
G
A
T
L
R
D
H
L
-------------------------------------
26
HHSearch
67.34
32%
1
- C4 -
-
5TLC
-
?
A:
[6-446]
-------
Q
L
H
L
A
G
F
F
S
A
G
N
V
T
H
A
H
G
A
------
W
R
H
V
G
A
T
-
N
G
F
L
T
G
E
F
Y
K
Q
I
A
R
T
L
E
R
G
K
F
D
L
L
F
L
P
D
G
L
A
I
E
D
S
-----
N
L
E
T
G
V
G
L
G
G
Q
G
-
A
V
A
L
E
P
T
S
V
I
A
T
M
A
A
V
T
Q
R
L
G
L
G
A
T
V
S
T
T
Y
Y
P
P
Y
H
V
A
R
V
F
A
T
L
D
N
L
S
D
G
R
I
S
W
N
V
V
T
S
L
N
D
S
E
A
R
N
F
G
V
D
E
H
L
E
H
D
I
R
Y
D
R
A
D
E
F
L
E
A
V
K
K
L
W
S
-
S
W
S
E
D
A
L
L
L
D
K
V
G
G
R
F
A
D
P
-
K
K
V
Q
Y
V
N
H
R
G
R
W
L
S
V
R
G
P
-
L
Q
V
P
R
S
R
Q
-
G
E
P
V
I
L
Q
A
-
G
L
S
P
R
G
R
R
F
A
G
R
W
A
E
A
V
F
-
S
V
S
P
N
L
D
I
M
R
A
V
Y
Q
D
I
K
A
H
V
A
A
A
G
R
D
P
E
Q
T
K
V
F
T
A
V
M
P
V
L
G
E
T
E
Q
V
A
R
E
R
L
E
Y
L
N
S
L
V
H
P
-
E
-
V
G
L
S
T
L
S
S
-
H
S
-
G
L
N
L
S
K
Y
P
L
D
----
T
K
-------
F
S
---
D
I
V
---
A
D
L
GDRHV
P
T
M
----------
L
Q
M
F
S
A
V
A
---
G
-
G
----
G
A
D
L
T
L
A
----
E
L
G
R
R
Y
--
G
T
---
N
V
G
F
V
-------
P
--
Q
W
A
G
T
A
E
Q
I
A
D
Q
L
I
S
H
F
E
A
G
A
A
D
G
F
I
I
S
P
A
Y
L
P
G
I
Y
E
E
F
V
D
Q
V
V
P
L
L
Q
Q
R
G
V
F
R
T
E
Y
E
G
T
T
L
R
E
H
L
G
L
A
H
---------------------------------
7
PsiBlast_PDB
66.75
26%
-19
- C4 -
-
5DQP
1
?
A:
[12-422]
---------------
L
N
S
S
G
V
L
P
N
S
-------
W
N
E
G
R
G
N
R
A
R
I
F
D
L
E
N
Y
I
R
S
A
E
I
A
R
R
G
R
I
D
A
F
F
L
A
D
----------
Q
P
Q
L
T
P
-
N
P
K
V
R
P
E
-
Y
P
-
F
D
P
I
V
L
A
A
A
I
T
G
R
V
P
D
I
G
G
I
V
T
A
S
T
S
F
S
L
P
Y
T
L
A
R
Q
I
A
S
V
N
L
L
S
G
G
R
I
G
W
N
A
V
T
T
A
N
P
A
V
A
A
N
Y
G
-
A
A
I
A
T
H
D
N
R
Y
E
R
A
E
E
F
L
E
V
V
H
G
L
W
N
-
S
W
K
---
F
P
W
D
E
A
I
G
P
N
P
N
P
F
G
E
V
M
P
I
N
H
E
G
K
Y
F
K
V
A
G
P
-
L
N
V
P
L
P
P
Y
-
G
P
P
V
V
V
Q
A
-
G
G
S
D
Q
G
K
R
L
A
S
R
F
G
E
I
I
Y
A
F
L
G
S
K
P
A
G
R
R
F
V
A
E
A
R
A
A
A
R
A
Q
G
R
P
E
G
S
T
L
-
V
L
P
S
F
V
P
L
I
G
S
T
E
A
E
V
K
R
L
V
A
E
Y
E
A
G
L
D
P
A
E
-
Q
R
I
E
A
L
S
K
-
Q
L
-
G
I
D
L
E
R
I
N
V
D
----
Q
V
LQEKDFN
L
P
---
K
E
S
---
A
-------
T
P
I
G
I
L
K
S
M
V
D
--
V
A
L
D
E
-
K
----
L
-
S
----
L
R
Q
---------------------
L
A
L
R
M
-------
R
--
L
I
A
G
T
P
D
Q
V
A
D
R
L
I
D
W
W
Q
D
E
A
A
D
G
F
V
I
N
A
P
L
L
P
D
A
L
E
I
F
V
D
Q
V
V
P
I
L
Q
S
R
G
V
F
P
R
S
Y
T
E
S
T
L
R
E
R
L
-------------------------------------
25
HHSearch
66.54
32%
-5
- C4 -
-
5TLC
-
?
C:
[6-446]
-------
Q
L
H
L
A
G
F
F
S
A
G
N
V
T
H
A
H
G
A
------
W
R
H
V
G
A
T
-
N
G
F
L
T
G
E
F
Y
K
Q
I
A
R
T
L
E
R
G
K
F
D
L
L
F
L
P
D
G
L
A
I
E
D
S
Y
--
G
D
N
L
E
T
G
V
G
L
G
G
Q
G
-
A
V
A
L
E
P
T
S
V
I
A
T
M
A
A
V
T
Q
R
L
G
L
G
A
T
V
S
T
T
Y
Y
P
P
Y
H
V
A
R
V
F
A
T
L
D
N
L
S
D
G
R
I
S
W
N
V
V
T
S
L
N
D
S
E
A
R
N
F
G
V
D
E
H
L
E
H
D
I
R
Y
D
R
A
D
E
F
L
E
A
V
K
K
L
W
S
-
S
W
S
E
D
A
L
L
L
D
K
V
G
G
R
F
A
D
P
-
K
K
V
Q
Y
V
N
H
R
G
R
W
L
S
V
R
G
P
-
L
Q
V
P
R
S
R
Q
-
G
E
P
V
I
L
Q
A
-
G
L
S
P
R
G
R
R
F
A
G
R
W
A
E
A
V
F
-
S
V
S
P
N
L
D
I
M
R
A
V
Y
Q
D
I
K
A
H
V
A
A
A
G
R
D
P
E
Q
T
K
V
F
T
A
V
M
P
V
L
G
E
T
E
Q
V
A
R
E
R
L
E
Y
L
N
S
L
V
H
P
-
E
-
V
G
L
S
T
L
S
S
-
H
S
-
G
L
N
L
--------------------------------------------------------------------------------
E
L
G
R
R
Y
--
G
T
---
N
V
G
F
V
-------
P
--
Q
W
A
G
T
A
E
Q
I
A
D
Q
L
I
S
H
F
E
A
G
A
A
D
G
F
I
I
S
P
A
Y
L
P
G
I
Y
E
E
F
V
D
Q
V
V
P
L
L
Q
Q
R
G
V
F
R
T
E
Y
E
G
T
T
L
R
E
H
L
G
L
A
H
---------------------------------
44
Fugue
63.66
24%
-65
- C4 -
-
1M41
-
SSUD_ECOLI
A:
[1-361]
------------
S
L
N
M
F
W
F
L
P
T
H
G
D
G
------
H
Y
L
G
T
E
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
I
P
T
-----------------------
G
-
R
S
C
E
D
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
R
P
S
V
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
L
A
G
D
G
V
F
--
L
D
H
S
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
L
Q
R
-----------------------
E
T
V
D
F
N
G
K
H
I
H
V
R
G
A
K
L
L
F
P
A
I
Q
Q
-
P
Y
P
P
L
Y
F
G
-
G
S
S
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
-
T
W
G
E
P
P
E
L
V
K
E
K
I
E
Q
V
R
A
K
A
A
A
H
G
R
---
K
I
R
F
G
I
R
L
H
V
I
V
R
E
T
N
D
E
A
W
Q
A
A
E
R
L
I
S
H
L
L
E
-
I
-
S
P
N
L
W
A
G
V
-
G
L
-
V
------------------------------------------------------------------------------------------------
R
G
G
A
G
-------
T
--
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
A
L
-
G
I
D
S
F
V
L
S
G
Y
P
H
L
E
E
A
Y
R
V
G
E
L
L
F
P
L
L
D
V
-------------------
A
I
-
P
E
-
I
P
Q
P
Q
P
L
----------------------
4
PsiBlast_PDB
61.24
30%
25
- C4 -
-
1TVL
-
MOXC_BACSU
A:
[3-432]
------------
R
A
D
F
I
Q
F
G
A
M
I
H
G
V
GGTTDG
W
R
H
P
D
V
D
P
S
A
S
T
N
I
E
F
Y
M
K
K
A
Q
T
A
E
K
G
L
F
S
F
I
F
I
A
D
--
G
L
F
-
I
S
--
E
K
S
I
P
H
-
F
L
N
R
-------
F
E
P
I
T
I
L
S
A
L
A
S
V
T
K
N
I
G
L
V
G
T
F
S
T
S
F
T
E
P
F
T
I
S
R
Q
L
M
S
L
D
H
I
S
G
G
R
A
G
W
N
L
V
T
S
P
Q
E
G
A
A
R
N
H
S
K
S
N
L
P
E
H
T
E
R
Y
E
I
A
Q
E
H
L
D
V
V
R
G
L
W
N
-
S
W
E
H
D
A
F
I
H
N
K
K
T
G
Q
F
F
D
Q
-
A
K
L
H
R
L
N
H
K
G
K
Y
F
Q
V
E
G
P
-
L
N
I
G
R
S
K
Q
-
G
E
P
V
V
F
Q
A
-
G
S
S
E
T
G
R
Q
F
A
A
K
N
A
D
A
I
F
-
T
H
S
N
S
L
E
E
T
K
A
F
Y
A
D
V
K
S
R
A
A
D
E
G
R
D
P
S
S
V
R
I
F
P
G
I
S
P
I
V
A
D
T
E
E
E
A
E
K
K
Y
R
E
F
A
E
L
I
P
I
-
E
-
N
A
V
T
----------------------------------------------------------------------------------
E
A
K
A
R
N
----
L
T
L
R
E
V
--
A
----
Q
E
M
A
F
-------
P
R
T
L
F
I
G
T
P
E
R
V
A
S
L
I
E
T
W
F
N
A
E
A
A
D
G
F
I
V
G
S
D
I
-
P
G
T
L
D
A
F
V
E
K
V
I
P
I
L
Q
E
R
G
L
Y
R
Q
D
Y
R
G
G
T
L
R
E
---
N
L
G
-
L
G
-
I
P
Q
--------------------------
34
HHSearch
61.12
19%
-52
- C4 -
-
3RAO
-
?
B:
[19-366]
-----
F
Q
G
V
E
Y
G
F
W
L
P
I
F
G
-----
G
W
------
L
R
N
V
N
D
E
-
S
M
P
P
T
F
E
Y
A
K
Q
T
A
Q
A
A
E
Q
L
G
F
S
T
T
L
I
A
E
L
N
L
N
D
--
I
--
K
G
----------
V
S
-
A
P
S
L
E
A
W
T
T
A
A
A
L
A
A
V
T
D
R
L
E
I
M
T
A
V
R
P
G
F
H
N
P
A
V
T
A
K
M
A
A
N
I
D
Q
L
S
N
G
R
F
T
L
N
V
V
S
A
W
W
E
E
E
A
K
Q
Y
G
G
V
F
-
T
A
H
D
E
R
Y
D
R
T
E
E
F
V
T
I
L
K
G
L
W
K
E
-----------------------
E
E
F
S
Y
K
G
N
F
Y
E
L
H
H
T
-
H
L
S
P
K
P
V
Q
K
Q
G
I
K
L
Y
A
G
-
G
E
S
K
R
G
K
E
V
I
V
N
H
A
D
A
Y
V
-
M
H
G
G
T
V
E
E
V
S
V
K
I
E
D
M
K
N
R
R
K
K
V
T
E
E
P
L
-
Q
S
F
G
L
A
A
Y
V
I
C
R
H
T
E
E
E
A
L
E
E
W
R
R
I
T
D
V
K
----------
A
L
G
-
Y
A
-
G
Y
--
Q
D
F
V
S
K
----
S
----------------------------
Q
L
----------
E
Q
Q
V
K
-------------
L
N
D
Y
S
-------
V
S
N
R
----------
G
L
R
-------
P
--
N
L
I
G
T
P
E
Q
I
A
E
R
I
L
A
F
E
K
-
V
G
V
T
L
L
L
L
Q
F
S
P
Q
L
E
E
M
K
R
F
S
E
K
V
M
P
L
V
E
A
K
R
----------------------------------------------------
32
HHSearch
59.31
24%
-38
- C4 -
-
1NQK
-
SSUD_ECOLI
A:
[3-362]
--------
L
N
M
F
W
F
L
P
T
----
H
G
D
G
H
------
Y
L
G
T
E
-
E
G
S
R
P
V
D
H
G
Y
L
Q
Q
I
A
Q
A
A
D
R
L
G
Y
T
G
V
L
I
P
T
G
R
------------------------
S
C
E
D
A
W
L
V
A
A
S
M
I
P
V
T
Q
R
L
K
F
L
V
A
L
R
P
S
V
T
S
P
T
V
A
A
R
Q
A
A
T
L
D
R
L
S
N
G
R
A
L
F
N
L
V
T
G
S
D
P
Q
E
L
A
G
D
G
V
F
--
L
D
H
S
E
R
Y
E
A
S
A
E
F
T
Q
V
W
R
R
L
L
Q
R
-----------------------
E
T
V
D
F
N
G
K
H
I
H
V
R
G
A
-
K
L
L
F
P
A
I
Q
Q
P
Y
P
P
L
Y
F
G
-
G
S
S
D
V
A
Q
E
L
A
A
E
Q
V
D
L
Y
L
-
T
W
G
E
P
P
E
L
V
K
E
K
I
E
Q
V
R
A
K
A
A
A
H
G
R
K
---
I
R
F
G
I
R
L
H
V
I
V
R
E
T
N
D
E
A
W
Q
A
A
E
R
L
I
S
H
L
D
D
-
E
-
T
-
I
A
K
A
Q
A
-
A
F
-
A
R
---------------------------------------------------------
D
N
L
----
E
I
S
----
P
N
L
W
A
G
V
----
G
L
V
R
----------
G
G
A
G
-------
T
--
A
L
V
G
D
G
P
T
V
A
A
R
I
N
E
Y
A
A
-
L
G
I
D
S
F
V
L
S
G
Y
P
H
L
E
E
A
Y
R
V
G
E
L
L
F
P
L
L
D
V
A
I
P
E
------
I
P
Q
P
Q
P
L
-------------------------------------