@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VR79: (2017-12-01 )
MSVTLGTPLQSSAFKVLLLGSGELGKEVVISLQRLGVEVHAADRYDHAPAMQVAHFSYVLNMADPAQLKQLIEKVKPNLIVPEIEAIATEVLLEIEANKTATVIPSAKAVNLTMNREGIRRLAAEELGLPTSAYRFADTLESFCAACDDIGYPNFVKPVMSSSGRGQSRVKSFDEVDAAWEYAMQGGRVNQGTVIIESQIDFDFEITLLTVRAKNPETGEIETHYCDPIGHRQDAGDYVESWQPQPMTPAALEEAKRIANKVTTALGGCGIFGVELFIKGDKVWFSEVSPRPHDTGLVTLASQFQSEFELHARAILGLPVNTARHSVAASAVIYAGVDANNLSYSNLNVALAHPDTDLRLFGKPEGFKRRRMGVATARAENTDLARTLAKETADQVSVQTNS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...--....310.......320..-..---------...330........340.......350-...-....360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSVTLGTPLQSS
A
F
K
V
L
L
L
GSGEL
G
K
E
V
V
I
S
L
Q
R
L
G
V
E
V
H
AADRYDHAP
A
M
Q
V
A
H
F
S
Y
V
LNMA
D
P
A
Q
L
K
Q
L
I
E
KVKP
N
L
IV
P
E
I
E
A
I
A
T
E
V
L
L
E
I
EANK
T
A
T
VIPS
A
K
A
V
N
L
T
M
N
R
E
G
I
R
R
L
A
A
E
ELGLP
T
S
A
Y
R
F
A
D
T
L
E
S
F
C
A
A
C
DDIGY
P
N
F
V
K
P
V
MSSSGR
G
Q
S
R
V
K
S
F
D
E
V
D
A
A
W
E
Y
A
MQGGRVNQ
G
T
V
I
I
E
S
QI
D
F
D
F
E
I
T
L
L
T
V
RAKNPETGE
I
E
T
HYCDPIGHRQD
A
G
D
Y
V
E
SWQPQPM
T
P
A
A
L
E
E
A
K
R
I
A
N
K
V
T
T
A
LGGC
G
I
F
G
V
E
L
F
I
KGD
K
V
W
FSEVSPRPHD
T
G
L
V
T
L
A
S
Q
F
Q
--
S
E
F
E
L
H
A
R
A
I
LGLPVN
T
A
R
-
H
S
---------
V
A
A
S
A
-
V
I
Y
AGVDANNLSYSN
L
N
V
A
L
A-HPD-T
D
L
R
L
FGKPEGFKRRRM
G
V
A
TARAE
N
T
D
L
A
R
T
L
A
K
ET
A
D
Q
V
S
VQTNS
23
PsiBlast_CBE
94.69
58%
-90
- C1 -
-
1KJQ
9
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
----
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
--
A
G
A
G
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
7
PsiBlast_PDB
94.30
58%
-92
- C1 -
-
1KJQ
11
PURT_ECOLI
A:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
---
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
A
G
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
1
PsiBlast_PDB
94.19
58%
-85
- C1 -
-
1EYZ
2
PURT_ECOLI
A:
[4-391]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
2
PsiBlast_PDB
93.92
58%
-88
- C1 -
-
1EZ1
3
PURT_ECOLI
A:
[4-391]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
22
PsiBlast_CBE
93.57
58%
-87
- C1 -
-
1EYZ
2
PURT_ECOLI
B:
[4-391]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
25
PsiBlast_CBE
93.53
58%
-87
- C1 -
-
1KJI
2
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
5
PsiBlast_PDB
93.51
58%
-87
- C1 -
-
1KJI
3
PURT_ECOLI
A:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
21
PsiBlast_CBE
93.43
58%
-86
- C1 -
-
1EZ1
3
PURT_ECOLI
B:
[4-391]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
24
PsiBlast_CBE
93.21
58%
-89
- C1 -
-
1KJJ
2
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
------
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
26
PsiBlast_CBE
92.96
58%
-88
- C1 -
-
1KJ9
3
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
----
G
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
4
PsiBlast_PDB
92.89
58%
-89
- C1 -
-
1KJ9
7
PURT_ECOLI
A:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
-----
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
3
PsiBlast_PDB
92.84
58%
-87
- C1 -
-
1KJ8
5
PURT_ECOLI
A:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
-----
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
6
PsiBlast_PDB
92.73
58%
-86
- C1 -
-
1KJJ
2
PURT_ECOLI
A:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
-----
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
51
HHSearch
92.66
58%
-87
- C1 -
-
1KJQ
9
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
-
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
----
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
--
A
G
A
G
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
---
G
V
--
H
F
C
A
-
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
-
Q
Y
---------
G
P
A
A
S
A
V
I
L
P
Q
--
L
T
S
Q
N
V
T
-
F
D
N
V
Q
N
A
V
G
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
27
PsiBlast_CBE
92.52
58%
-92
- C1 -
-
1KJ8
5
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
-
E
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
-------
G
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
G
------
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
Q
Y
G
---------
P
A
A
S
A
-
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
G
--
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
52
HHSearch
92.06
58%
-84
- C1 -
-
1KJI
2
PURT_ECOLI
B:
[3-390]
----
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
-
E
G
L
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
R
A
G
--
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
---
G
V
--
H
F
C
A
-
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
-
Q
Y
---------
G
P
A
A
S
A
V
I
L
P
Q
--
L
T
S
Q
N
V
T
-
F
D
N
V
Q
N
A
V
G
A
D
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
---
42
Fugue
91.91
57%
-95
- C1 -
-
1EZ1
3
PURT_ECOLI
A:
[2-392]
--
T
L
L
G
T
A
L
R
P
A
A
T
R
V
M
L
L
G
S
G
E
L
G
K
E
V
A
I
E
C
Q
R
L
G
V
E
V
I
A
V
D
R
Y
A
D
A
P
A
M
H
V
A
H
R
S
H
V
I
N
M
L
D
G
D
A
L
R
R
V
V
E
L
E
K
P
H
Y
I
V
P
E
I
E
A
I
A
T
D
M
L
I
Q
L
E
E
E
G
L
-
N
V
V
P
C
A
R
A
T
K
L
T
M
N
R
E
G
I
R
R
L
A
A
E
E
L
Q
L
P
T
S
T
Y
R
F
A
D
S
E
S
L
F
R
E
A
V
A
D
I
G
Y
P
C
I
V
K
P
V
M
S
S
S
G
K
G
Q
T
F
I
R
S
A
E
Q
L
A
Q
A
W
K
Y
A
Q
Q
G
G
--
R
A
G
R
V
I
V
E
G
V
V
K
F
D
F
E
I
T
L
L
T
V
S
A
V
D
------
G
V
H
F
C
A
P
V
G
H
R
Q
E
D
G
D
Y
R
E
S
W
Q
P
Q
Q
M
S
P
L
A
L
E
R
A
Q
E
I
A
R
K
V
V
L
A
L
G
G
Y
G
L
F
G
V
E
L
F
V
C
G
D
E
V
I
F
S
E
V
S
P
R
P
H
D
T
G
M
V
T
L
I
S
Q
D
L
--
S
E
F
A
L
H
V
R
A
F
L
G
L
P
V
G
G
I
R
-
Q
Y
---------
G
P
A
A
S
-
A
V
I
L
P
Q
L
T
S
Q
N
V
T
F
D
N
V
Q
N
A
V
-
G
A
D
-
L
Q
I
R
L
F
G
K
P
E
I
D
G
S
R
R
L
G
V
A
L
A
T
A
E
S
V
V
D
A
I
E
R
A
K
H
A
A
G
Q
V
K
V
Q
G
--
8
PsiBlast_PDB
88.87
47%
-81
- C1 -
-
2CZG
9
PURT_PYRHO
A:
[11-417]
----
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
G
K
E
I
A
I
E
A
Q
R
L
G
V
E
V
V
A
V
D
R
Y
A
N
A
P
A
M
Q
V
A
H
R
S
Y
V
G
N
M
M
D
K
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
L
F
E
F
E
K
D
G
Y
-
F
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
L
V
K
E
A
K
V
P
T
S
R
Y
M
Y
A
T
T
L
D
E
L
Y
E
A
C
E
K
I
G
Y
P
C
H
T
K
A
I
M
S
------
Y
F
V
K
G
P
E
D
I
P
K
A
W
-----------
E
K
I
I
V
E
E
H
I
D
F
D
V
E
V
T
E
L
A
V
R
H
F
D
-
E
N
G
E
I
V
T
T
F
P
K
P
V
G
H
Y
Q
I
D
G
D
Y
H
A
S
W
Q
P
A
E
I
S
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
G
L
G
I
F
G
V
E
M
F
V
K
G
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
S
H
P
P
GF
S
E
F
A
L
H
L
R
A
V
L
G
L
P
I
P
G
E
W
-
V
D
GYR
L
F
P
M
L
I
P
A
A
T
H
-
V
I
K
A
K
V
S
G
Y
S
P
R
F
R
G
L
V
K
A
L
S
-
V
P
N
-
A
T
V
R
L
F
G
K
P
E
A
Y
V
G
R
R
L
G
I
A
L
A
W
D
K
D
V
E
V
A
K
R
K
A
E
M
V
A
H
M
I
E
L
R
T
R
S
28
PsiBlast_CBE
88.80
47%
-79
- C1 -
-
2DWC
1
PURT_PYRHO
B:
[11-417]
----
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
G
K
E
I
A
I
E
A
Q
R
L
G
V
E
V
V
A
V
D
R
Y
A
N
A
P
A
M
Q
V
A
H
R
S
Y
V
G
N
M
M
D
K
D
F
L
W
S
V
V
E
R
E
K
P
D
A
I
I
P
E
I
E
A
I
N
L
D
A
L
F
E
F
E
K
D
G
Y
-
F
V
V
P
N
A
R
A
T
W
I
A
M
H
R
E
R
L
R
E
T
L
V
K
E
A
K
V
P
T
S
R
Y
M
Y
A
T
T
L
D
E
L
Y
E
A
C
E
K
I
G
Y
P
C
H
T
K
A
I
M
S
----
G
S
Y
F
V
K
G
P
E
D
I
P
K
A
W
E
E
---------
E
K
I
I
V
E
E
H
I
D
F
D
V
E
V
T
E
L
A
V
R
H
F
D
-
E
N
G
E
I
V
T
T
F
P
K
P
V
G
H
Y
Q
I
D
G
D
Y
H
A
S
W
Q
P
A
E
I
S
E
K
A
E
R
E
V
Y
R
I
A
K
R
I
T
D
V
L
G
G
L
G
I
F
G
V
E
M
F
V
K
G
D
K
V
W
A
N
E
V
S
P
R
P
H
D
T
G
M
V
T
L
A
S
H
P
P
GF
S
E
F
A
L
H
L
R
A
V
L
G
L
P
I
P
G
E
W
-
V
D
GYR
L
F
P
M
L
I
P
A
A
T
H
-
V
I
K
A
K
V
S
G
Y
S
P
R
F
R
G
L
V
K
A
L
S
-
V
P
N
-
A
T
V
R
L
F
G
K
P
E
A
Y
V
G
R
R
L
G
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A
L
A
W
D
K
D
V
E
V
A
K
R
K
A
E
M
V
A
H
M
I
E
L
R
T
R
S
9
PsiBlast_PDB
87.55
47%
-77
- C1 -
-
2DWC
1
PURT_PYRHO
A:
[11-417]
----
L
G
T
A
T
T
D
S
A
Q
K
I
L
L
L
G
S
G
E
L
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L
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M
M
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V
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I
I
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N
L
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A
L
F
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F
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D
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Y
-
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N
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R
A
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R
L
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A
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T
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E
L
Y
E
A
C
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Y
P
C
H
T
K
A
I
M
S
------
Y
F
V
K
G
P
E
D
I
P
K
A
W
E
E
---------
E
K
I
I
V
E
E
H
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D
F
D
V
E
V
T
E
L
A
V
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L
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L
P
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D
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L
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L
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A
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A
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