@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRA8: (2017-12-01 )
MKFEKLGQSGRARRGRLTLEHGVVETPIFMPVGTYGTVKGMLPRDIEDIQAQIILGNTFHLYLRPGLEVIKQHGGLHDFIKWNKPILTDSGGFQVFSLGAMRKIKEEGVTFRSPIDGSKVFLSPEISMEIQHVLNSDIVMIFDECTPYPATHEEAQKSLQLSLRWAKRCKAHHHDELKNKNALFGIIQGGMYEDLRDESLNGLLEIGFDGYAIGGLSVGEPKEEMIKVLDYLPNKMPHDKPRYLMGVGKPEDIVEAVRRGVDMFDCVMPTRNARNGHYFVTDGLVRIRNSKYRHDQGPLDPHCDCYTCKNFTRAYLFHLEKCGEMLASMLGTIHNLRYYQRLTEGMRDALDKGTFDEFVQDFYARRGLEVPPCPVDE
Atome Classification :
(94 SA)
---.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170--..--...--..180.......190.......200.......210.......220--........230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---M
K
F
E
K
LGQSGRARRG
R
L
T
L
EHGVVET
P
I
F
M
PVGTYGTVKGMLPR
D
I
E
D
I
Q
A
Q
I
I
LG
N
T
F
H
L
Y
LRP
G
L
E
V
I
K
Q
HGGL
H
D
F
IKWNK
P
I
LTDSGG
F
Q
V
F
S
L
G
A
M
R
K
I
K
EEG
V
T
FRSPIDG
S
K
V
F
LSP
E
I
S
M
E
I
Q
H
V
LNS
D
I
V
M
I
FDECTPYPA
T
H
E
E
A
Q
K
S
L
Q
L
S
L
R
W
A
K
R
C
K
AH--
H
H
--
D
E
L--KNKN
A
L
F
G
I
IQGG
M
Y
E
D
L
R
D
E
S
LNG
L
L
EIGFD
G
Y
A
IGGLSVGE
P
---
K
E
E
M
I
K
V
L
D
YLPNKMPHDKP
R
Y
L
MGVG
K
P
E
D
I
V
E
A
V
R
RGV
D
M
F
D
CVMPTRNARNG
H
Y
F
VTDG
L
V
R
IRNSKYRHDQGPLDPHCD
C
Y
T
C
K
N
F
T
R
A
Y
L
F
H
L
E
K
C
G
E
M
L
A
S
M
L
G
T
I
H
N
L
R
Y
Y
Q
R
L
T
E
G
M
R
D
A
LDKG
T
F
D
E
F
V
Q
D
F
Y
A
RRGLEVPPCPVDE
114
HHSearch
92.82
52%
-98
- C6 -
-
2ASH
3
TGT_THEMA
D:
[13-375]
---
M
E
F
E
V
K
K
T
F
G
K
A
R
L
G
V
M
K
L
H
H
G
A
V
E
T
P
V
F
M
P
V
G
T
N
A
S
V
K
L
L
T
P
R
D
L
E
E
A
G
A
E
I
I
L
S
N
T
F
H
L
M
L
K
P
G
V
E
I
I
K
L
H
R
G
L
H
N
F
M
G
W
K
R
P
I
L
T
D
S
G
G
F
Q
V
F
S
L
P
K
I
R
-
I
D
D
E
G
V
V
F
R
S
P
I
D
G
S
K
V
F
L
N
P
E
I
S
M
E
V
Q
I
A
L
G
S
D
I
C
M
V
F
D
H
C
P
V
--
A
D
Y
E
E
V
K
E
A
T
E
R
T
Y
R
W
A
L
R
S
K
K
A
--
F
K
-------
T
E
N
Q
A
L
F
G
I
V
Q
G
G
I
Y
P
D
L
R
R
E
S
A
L
Q
L
T
S
I
G
F
D
G
Y
A
I
G
G
L
S
I
G
E
E
---
R
S
L
T
L
E
M
T
E
V
T
V
E
F
L
P
E
D
K
P
R
Y
F
M
G
G
G
S
P
E
L
I
L
E
L
V
D
R
G
V
D
M
F
D
S
V
F
P
T
R
I
A
R
H
G
T
A
L
T
W
N
G
K
L
N
L
K
A
S
Y
N
K
R
S
L
E
P
V
D
E
R
C
G
C
Y
T
C
K
N
F
T
R
S
Y
I
H
H
L
F
D
R
G
E
V
L
G
Q
I
L
L
T
I
H
N
I
N
F
M
I
S
L
M
K
E
V
R
R
S
I
E
S
G
T
F
K
E
L
K
S
K
V
V
E
V
Y
S
----------
97
PsiBlast_CBE
85.29
54%
-24
- C6 -
-
4GD0
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
29
PsiBlast_CBE
85.02
54%
-22
- C6 -
-
5JGM
7
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
68
PsiBlast_CBE
84.83
54%
-23
- C6 -
-
1Q2R
2
TGT_ZYMMO
D:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
79
PsiBlast_CBE
84.44
54%
-21
- C6 -
-
5SW3
7
?
A:
[6-371]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
-
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
---
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
26
PsiBlast_CBE
84.43
54%
-22
- C6 -
-
5JSW
12
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
--
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
31
PsiBlast_CBE
84.38
54%
-19
- C6 -
-
5J9M
4
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
28
PsiBlast_CBE
84.37
54%
-21
- C6 -
-
5JGO
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
73
PsiBlast_CBE
84.20
54%
-18
- C6 -
-
4Q8V
2
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
47
PsiBlast_CBE
84.14
54%
-20
- C6 -
-
4PUK
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
57
PsiBlast_CBE
84.06
54%
-19
- C6 -
-
3RR4
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
22
PsiBlast_CBE
84.04
54%
-19
- C6 -
-
5JXQ
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
70
PsiBlast_CBE
84.03
54%
-23
- C6 -
-
1Q2R
2
TGT_ZYMMO
B:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
69
PsiBlast_CBE
84.03
54%
-20
- C6 -
-
1Q2R
2
TGT_ZYMMO
C:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
72
PsiBlast_CBE
84.01
54%
-19
- C6 -
-
4Q8W
5
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
13
PsiBlast_PDB
84.00
54%
-19
- C6 -
-
1P0B
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
11
PsiBlast_PDB
84.00
54%
-19
- C6 -
-
1Q2R
2
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
30
PsiBlast_CBE
83.96
54%
-19
- C6 -
-
5J9N
4
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
H
--
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
113
HHSearch
83.95
53%
-23
* C6 *
-
4Q8W
5
TGT_ZYMMO
A:
[16-385]
---
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
-
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
--
F
D
--
S
R
K
E
Q
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
A
---------
65
PsiBlast_CBE
83.87
54%
-20
- C6 -
-
1Q2S
2
TGT_ZYMMO
D:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
98
PsiBlast_CBE
83.81
54%
-19
- C6 -
-
4E2V
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
------
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
25
PsiBlast_CBE
83.76
54%
-18
- C6 -
-
5JT5
5
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
75
PsiBlast_CBE
83.75
54%
-23
- C6 -
-
4LBU
4
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
19
PsiBlast_PDB
83.74
54%
-21
- C6 -
-
2BBF
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
74
PsiBlast_CBE
83.73
54%
-20
- C6 -
-
4LEQ
3
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
-
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
81
PsiBlast_CBE
83.65
53%
-21
- C6 -
-
1EFZ
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
A
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
2
PsiBlast_PDB
83.58
54%
-18
- C6 -
-
1OZQ
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
12
PsiBlast_PDB
83.52
54%
-18
- C6 -
-
1Q2S
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
96
PsiBlast_CBE
83.49
54%
-18
- C6 -
-
4H7Z
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
24
PsiBlast_CBE
83.47
54%
-19
- C6 -
-
5JT6
3
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
H
--
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
59
PsiBlast_CBE
83.41
54%
-20
- C6 -
-
3GC5
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
6
PsiBlast_PDB
83.39
54%
-18
- C6 -
-
1ENU
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
17
PsiBlast_PDB
83.36
54%
-23
- C6 -
-
1Q66
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
--
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
---
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
78
PsiBlast_CBE
83.35
54%
-20
- C6 -
-
5I00
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
20
PsiBlast_PDB
83.32
54%
-22
- C6 -
-
2QII
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
8
PsiBlast_PDB
83.32
54%
-18
- C6 -
-
1K4G
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
39
PsiBlast_CBE
83.27
54%
-17
- C6 -
-
4Q8T
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
89
PsiBlast_CBE
83.15
53%
-19
- C6 -
-
4Q8M
8
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
45
PsiBlast_CBE
83.14
54%
-22
- C6 -
-
4Q4M
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
16
PsiBlast_PDB
83.13
54%
-19
- C6 -
-
1Q65
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
27
PsiBlast_CBE
83.05
54%
-22
- C6 -
-
5JSV
4
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
42
PsiBlast_CBE
83.03
54%
-22
- C6 -
-
4Q4Q
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
7
PsiBlast_PDB
82.92
54%
-18
- C6 -
-
1F3E
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
32
PsiBlast_CBE
82.85
54%
-18
- C6 -
-
5I09
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
-
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
38
PsiBlast_CBE
82.79
54%
-18
- C6 -
-
4Q8U
8
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
48
PsiBlast_CBE
82.77
54%
-20
- C6 -
-
4PUJ
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
44
PsiBlast_CBE
82.74
54%
-18
- C6 -
-
4Q4O
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
9
PsiBlast_PDB
82.73
54%
-18
- C6 -
-
1K4H
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
88
PsiBlast_CBE
82.65
53%
-22
- C6 -
-
4Q8O
5
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
T
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
4
PsiBlast_PDB
82.54
54%
-19
- C6 -
-
1Y5X
1
TGT_ZYMMO
A:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
94
PsiBlast_CBE
82.53
53%
-18
- C6 -
-
4PUL
2
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
N
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
66
PsiBlast_CBE
82.53
54%
-21
- C6 -
-
1Q2S
2
TGT_ZYMMO
C:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
90
PsiBlast_CBE
82.38
54%
-17
- C6 -
-
4HSH
8
TGT_ZYMMO
A:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
----
T
K
Q
S
E
E
G
V
T
F
K
S
H
----
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
58
PsiBlast_CBE
82.37
54%
-21
- C6 -
-
3GE7
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
80
PsiBlast_CBE
82.36
53%
-21
- C6 -
-
2OKO
16
TGT_ZYMMO
A:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
23
PsiBlast_CBE
82.21
54%
-21
- C6 -
-
5JT7
3
?
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
---
Q
S
E
E
G
V
T
F
K
S
------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
18
PsiBlast_PDB
82.12
54%
-20
- C6 -
-
1S38
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
40
PsiBlast_CBE
82.08
54%
-19
- C6 -
-
4Q4S
5
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
--
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
37
PsiBlast_CBE
81.99
54%
-21
- C6 -
-
5EGR
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
93
PsiBlast_CBE
81.96
53%
-17
- C6 -
-
4PUM
3
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
---
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
N
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
95
PsiBlast_CBE
81.95
54%
-20
- C6 -
-
4HVX
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
-------
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
V
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
56
PsiBlast_CBE
81.95
54%
-17
- C6 -
-
3SM0
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
43
PsiBlast_CBE
81.95
54%
-20
- C6 -
-
4Q4P
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
41
PsiBlast_CBE
81.69
54%
-20
- C6 -
-
4Q4R
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
83
PsiBlast_CBE
81.63
53%
-21
- C6 -
-
2Z1W
9
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
100
PsiBlast_CBE
81.62
53%
-26
- C6 -
-
4Q8Q
1
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
---
L
T
K
Q
S
E
E
G
V
T
F
K
S
----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
C
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
99
PsiBlast_CBE
81.58
53%
-28
- C6 -
-
1PXG
9
TGT_ZYMMO
A:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
E
C
V
--------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
15
PsiBlast_PDB
81.55
54%
-19
- C6 -
-
1P0E
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
85
PsiBlast_CBE
81.45
53%
-23
- C6 -
-
2PWV
7
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
53
PsiBlast_CBE
81.31
54%
-20
- C6 -
-
4GH1
2
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
------
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
104
Fugue
81.23
53%
-2
- C6 -
-
1K4G
1
TGT_ZYMMO
A:
[11-382]
RPR
F
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
--
F
D
S
R
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
---GEG
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
Y
F
----------
82
PsiBlast_CBE
81.19
53%
-20
- C6 -
-
2Z1X
9
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
33
PsiBlast_CBE
81.02
54%
-21
- C6 -
-
5I07
4
TGT_ZYMMO
B:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
--------
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
51
PsiBlast_CBE
80.99
54%
-22
- C6 -
-
4GI4
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
34
PsiBlast_CBE
80.92
54%
-19
- C6 -
-
5I07
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
--------
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
S
H
L
D
G
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
63
PsiBlast_CBE
80.82
54%
-16
- C6 -
-
3C2Y
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
3
PsiBlast_PDB
80.57
54%
-19
- C6 -
-
1Y5V
3
TGT_ZYMMO
A:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-----
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
49
PsiBlast_CBE
80.54
54%
-20
- C6 -
-
4GKT
2
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
-------
T
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
36
PsiBlast_CBE
80.53
54%
-26
- C6 -
-
5I03
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
------
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
60
PsiBlast_CBE
80.47
54%
-17
- C6 -
-
3GC4
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
----------
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
52
PsiBlast_CBE
80.23
54%
-20
- C6 -
-
4GH3
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
--
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
-----
K
Q
S
E
E
G
V
T
F
---------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
35
PsiBlast_CBE
79.96
54%
-16
- C6 -
-
5I06
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
---------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
--
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
64
PsiBlast_CBE
79.89
54%
-20
- C6 -
-
2PWU
4
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
---
K
Q
S
E
E
G
V
T
F
K
S
-------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
-----
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
62
PsiBlast_CBE
79.88
54%
-27
- C6 -
-
3EOS
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
----
K
Q
S
E
E
G
V
T
F
--------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
-----
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
86
PsiBlast_CBE
79.55
53%
-20
- C6 -
-
2POT
8
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
-----------
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
Q
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
61
PsiBlast_CBE
79.37
54%
-27
- C6 -
-
3EOU
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
76
PsiBlast_CBE
79.33
54%
-20
- C6 -
-
4KWO
2
TGT_ZYMMO
A:
[17-382]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
-------------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
77
PsiBlast_CBE
79.30
54%
-23
- C6 -
-
5I02
6
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
-------------
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-------
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
5
PsiBlast_PDB
79.01
54%
-19
- C6 -
-
2QZR
3
TGT_ZYMMO
A:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
-----
S
E
E
G
V
T
F
K
--------
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
21
PsiBlast_CBE
78.82
54%
-18
- C6 -
-
1Y5X
1
TGT_ZYMMO
D:
[14-379]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
---------------
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
S
L
T
K
Q
S
E
E
G
V
T
F
K
-----
S
R
H
M
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
FD
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
55
PsiBlast_CBE
78.78
54%
-22
- C6 -
-
4FR1
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
-----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
-------
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
-
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
91
PsiBlast_CBE
78.73
54%
-18
- C6 -
-
3BLD
3
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
A
A
T
V
K
A
L
K
P
E
T
V
R
A
T
G
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
F
Q
V
M
S
------
Q
S
E
E
G
V
T
F
K
S
--------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
G
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
----------
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
54
PsiBlast_CBE
78.55
54%
-24
- C6 -
-
4FR6
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
----
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------
50
PsiBlast_CBE
77.20
54%
-20
- C6 -
-
4GIY
1
TGT_ZYMMO
A:
[15-380]
----
S
F
S
I
A
A
R
E
G
K
A
R
T
G
T
I
E
M
K
R
G
V
I
R
T
P
A
F
M
P
V
G
T
----------------
A
D
I
I
L
G
N
T
Y
H
L
M
L
R
P
G
A
E
R
I
A
K
L
G
G
L
H
S
F
M
G
W
D
R
P
I
L
T
D
S
G
G
Y
Q
V
M
S
L
S
--
T
K
Q
S
E
E
G
V
T
F
----------
L
S
P
E
R
S
I
E
I
Q
H
L
L
G
S
D
I
V
M
A
F
D
E
C
T
P
Y
P
A
T
P
S
R
A
A
S
S
M
E
R
S
M
R
W
A
K
R
S
R
D
A
F
D
S
R
--
K
E
Q
--
A
E
N
A
A
L
F
G
I
Q
Q
G
S
V
F
E
N
L
R
Q
Q
S
A
D
A
L
A
E
I
G
F
D
G
Y
A
V
G
G
L
A
V
G
E
G
---
Q
D
E
M
F
R
V
L
D
F
S
V
P
M
L
P
D
D
K
P
H
Y
L
M
G
V
G
K
P
D
D
I
V
G
A
V
E
R
G
I
D
M
F
D
C
V
L
P
T
R
S
G
R
N
G
Q
A
F
T
W
D
G
P
I
N
I
R
N
A
R
F
S
E
D
L
K
P
L
D
S
E
C
H
C
A
V
C
Q
K
W
S
R
A
Y
I
H
H
L
I
R
A
G
E
I
L
G
A
M
L
M
T
E
H
N
I
A
F
Y
Q
Q
L
M
Q
K
I
R
D
S
I
S
E
G
R
F
S
Q
F
A
Q
D
F
R
A
R
------------