@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRJ6: (2017-12-03 )
MSDIKNLRNIAIIAHVDHGKTTLVDKLLQQSGALGDRAGEIERVMDSNALESERGITILAKNTAITWLDKRTDTTYRINIVDTPGHADFGGEVERVMSMVDCVLLLVDSQEGPMPQTRFVTQKAFARGLKPIVIINKVDKPSARPDWVIDQVFDLFDNLGATDEQLDFPIVYASGLRGVAGPAPEELAEDMTPLFETIVDIVEPPAVDVDGPFQMQISSLDYNSFVGVIGVGRIQRGFVKLNTPVTVIDKEGNTRNGRILKIMGYHGLERIDVDSASAGDIVCITGIDALNISDTICDPKNVEALPPLSVDEPTVSMTFQVNNSPFAGKEGKFVTSRNIRERLDRELIHNVALRVEDTDSPDRFKVSGRGELHLSVLIENMRREGFELGVSRPQVIIKEIDGEKQEPYENVTFDVEEQHQGAVMEQMGHRKGEMTNMEVDGKGRIRIEATVPSRGLIGFRSEFLTMTSGTGIMTSSFSHYGPLKQGTVAKRQNGVLISMVQGTCLGYALFSLQDRGRLFAKPQLEVYEGMIVGINSRSDDMVVNPTKAKQLTNVRASGTDDALTLTPAIEFTLEQALEFIEDDELVEVTPKSIRIRKRYLTENERKRNRDK
Atome Classification :
(20 SA)
.........10........20........30.......-------.40........50........60........70........80........90........100.......110.......120.......130.......140..-----------.-----------....150------------------------.....----.-----------------------------------------------------------------------.--------------------------------160-----------------------------------------.....------------.---...170.......180--.-------------------------------------------------------------------------------..---------.----------------..-.190........200.....---------------------------..210.......220...-....230.......240.......250------.---------------......260.........270.......280..----..----...290-.-......300-.--.------.-.....-.-310.......320.......330.......340.......350.......---360.---......370.......380..--.-....390......---------.--400---------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------...-----------.....410.......420.......430-.......440.-.......450...-..-..460.......470.......--480.......490......----------------.500.......510.......520.......530.-......540.......550.......560.......570.......580.......590.......600.......610-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
D
I
K
N
LR
N
I
A
I
I
A
H
VDHG
K
T
T
L
V
D
K
L
L
Q
QSGALGDRA-------
G
E
I
E
R
V
M
DSNALESER
G
I
T
I
L
AKN
T
A
I
T
W
L
DKRTD
T
T
Y
R
I
N
I
V
DTPGHADFG
G
E
V
E
R
V
M
S
M
V
D
C
V
L
L
L
V
DSQEGPMP
Q
T
R
F
V
T
Q
K
A
F
ARGL
K
P
I
V
I
I
N
KVDKPSAR-----------P-----------
D
W
V
I
D
Q
V
------------------------
F
D
L
F
D
----N-----------------------------------------------------------------------L--------------------------------G-------------------------------------------ATDEQ------------L---D
F
P
I
V
Y
ASGLRGVAGP--
A
-------------------------------------------------------------------------------
P
E
---------
E
----------------
L
A
-
E
D
-
M
T
P
L
F
E
T
I
V
D
IVEPPAV---------------------------DVDGP
F
Q
M
Q
I
SSLDYNS
F
-
V
G
V
I
G
V
G
R
IQR
G
F
V
K
LNT
P
V
T
V
I
DKEG------N---------------TRN
G
R
I
L
--
K
I
MGYHG
L
E
R
IDVDSASAG
D
I
V
C
I
----TG----IDALNI-S-DTICDPK---N--V------E-ALPPL-S-VDEP
T
V
S
M
T
F
Q
VNNSPFAGKEG
K
F
V
T
S
R
N
I
R
E
R
L
D
R
E
L
I
H
N
V
A
L
R
VEDTD---SPD
R
---
F
K
VSGR
G
E
L
H
L
S
V
L
I
E
N
M
R
RE--G-FELGVSR
P
Q
V
I
I
K
---------E--I-----------------------------------------------------------------------------------------------------D--------------------------------------------------------------------------------------------------------------GEK-----------QEPYEN
V
T
F
D
V
E
E
Q
HQ
G
A
V
M
E
Q
MGHRKG-EMT
N
M
E
VDG-K-
G
R
I
R
I
E
A
TVPSRG-LI-GF
R
S
E
F
L
T
MTSGT
G
I
M
TSSFSH--YGPLKQG
T
V
AKRQN
G
V
L
I
S
----------------MVQG
T
C
L
G
Y
A
L
F
SLQDRG
R
L
FAKPQ
L
E
V
Y
E
G
M
I
V
G
-INSRSD
D
M
V
VNP
T
K
A
K
Q
L
T
N
VRASGTDD
A
L
T
L
T
P
A
I
E
F
T
L
E
Q
A
L
E
F
IEDD
E
L
V
E
VTP
K
S
I
R
I
R
K
R
YLT
E
N
E
R
KRNRDK--
2
PsiBlast_PDB
92.25
72%
-84
- C4 -
-
4ZCI
2
TYPA_ECOLI
A:
[35-633]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
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L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
76
HHSearch
91.47
72%
-84
- C4 -
-
4ZCI
2
TYPA_ECOLI
B:
[35-635]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
------
D
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
----
23
PsiBlast_CBE
90.87
72%
-85
- C4 -
-
4ZCI
2
TYPA_ECOLI
B:
[35-633]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
21
PsiBlast_CBE
89.87
72%
-82
- C4 -
-
4ZCM
3
TYPA_ECOLI
B:
[35-633]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
22
PsiBlast_CBE
89.21
72%
-83
- C4 -
-
4ZCL
3
TYPA_ECOLI
B:
[35-633]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
3
PsiBlast_PDB
88.71
72%
-84
- C4 -
-
4ZCL
3
TYPA_ECOLI
A:
[35-633]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
1
PsiBlast_PDB
88.16
72%
-82
* C4 *
-
4ZCM
3
TYPA_ECOLI
A:
[35-633]
--
M
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
-------------------------------
T
I
L
A
K
N
T
A
I
K
W
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
G
I
A
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
G
----
L
G
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
----------------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
5
PsiBlast_PDB
78.85
72%
-64
- C5 -
-
5A9X
1
TYPA_ECOLI
A:
[2-599]
---
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
--------------------------
K
E
R
G
I
T
I
L
A
K
N
T
A
----
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
G
G
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
---
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
-------
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
-----------------
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
4
PsiBlast_PDB
77.32
72%
-70
- C5 -
-
5A9W
1
TYPA_ECOLI
A:
[2-599]
---
I
E
K
L
R
N
I
A
I
I
A
H
V
D
H
G
K
T
T
L
V
D
K
L
L
Q
Q
S
G
T
-----------------------
L
E
K
E
R
G
I
T
I
L
A
K
N
T
A
---
N
D
------
Y
R
I
N
I
V
D
T
P
G
H
A
D
F
--
E
V
E
R
V
M
S
M
V
D
S
V
L
L
V
V
D
A
F
D
G
P
M
P
Q
T
R
F
V
T
K
K
A
F
A
Y
G
L
K
P
I
V
V
I
N
K
V
D
R
P
G
A
R
-----------
P
-----------
D
W
V
V
D
Q
V
------------------------
F
D
L
F
V
----
N
-----------------------------------------------------------------------
L
--------------------------------
D
-------------------------------------------
A
T
D
E
Q
------------
L
---
D
F
P
I
V
Y
A
S
A
L
N
---
G
L
--
D
-------------------------------------------------------------------------------
H
E
---------
D
----------------
M
A
-
E
D
-
M
T
P
L
Y
Q
A
I
V
D
H
V
P
A
P
D
V
---------------------------
D
L
D
G
P
F
Q
M
Q
I
S
Q
L
D
Y
N
S
Y
-
V
G
V
I
G
I
G
R
I
K
R
G
K
V
K
P
N
Q
Q
V
T
I
I
D
S
E
G
------
K
---------------
T
R
N
A
K
V
G
--
K
V
L
G
H
L
G
L
E
R
I
E
T
D
L
A
E
A
G
D
I
V
A
I
----
T
-------
E
L
N
I
-
S
-
D
T
V
C
D
T
Q
---
N
--
V
------
E
-
A
L
P
A
L
-
S
-
V
D
E
P
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
----------
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
85
HHSearch
58.20
30%
2
- C3 -
-
2BM0
1
?
A:
[8-682]
--
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
A
-------------------------
T
I
T
A
A
V
T
T
C
F
W
K
------
D
H
R
I
N
I
I
D
A
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
-----------
L
-----------
W
L
V
I
R
T
M
------------------------
Q
E
R
L
G
----
A
RPVVM
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
Y
GND---------------------------------------
L
--------------------------------
G
TDIREIPIPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
GEE
P
T
E
E
E
L
V
A
A
I
R
K
G
T
---
I
D
LK
I
T
P
V
F
L
G
S
A
L
--------------------------------------------------------------------------------------------------------------------
K
N
-
K
G
-
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
IP
P
I
K
G
T
T
PEG
E
V
V
E
I
H
P---------
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
-
T
K
G
-----------------------
R
K
E
R
V
A
--
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
----
L
K
E
T
I
T
-
G
-
D
T
L
V
G
E
D
---
A
--
P
------
R
V
I
L
E
S
I
-
E
-
V
P
E
P
V
I
D
V
A
I
E
----
P
K
T
K
A
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
---
E
T
G
Q
---
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F-
K
-
V
D
A
N
V
G
K
P
Q
V
A
Y
R
---------
E
T
-
I
-----------------------------------------------------------------------------------------------------
T
K
P
V
D
V
E
G
K
F
I
R
QTGG
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
PRGS
G
F
E
F
V
N
AIVGGVIPKEY
I
P
A
V
Q
K
G
I
E
E
A
M
QSGPLIGFPVVD
I
K
V
T
L
Y
D
G
S
Y
H
EVDSS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
-----------
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
---
N
A
Q
V
I
R
A
F
V
P
L
A
E
-
M
F
-
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
--
Y
Q
E
V
P
K
Q
------------------------------------------------------------------------------------------------------------------------------------------------
91
HHSearch
56.42
29%
-
- C3 -
-
1ZN0
-
EFG_THET8
B:
[7-682]
-
Y
D
L
K
R
L
R
N
I
G
I
A
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
A
---------------------------------
V
T
T
C
F
W
K
------
D
H
R
I
N
I
I
D
T
P
G
H
V
D
F
T
I
E
V
E
R
S
M
R
V
L
D
G
A
I
V
V
F
D
S
S
Q
G
V
E
P
Q
S
E
T
V
W
R
Q
A
E
K
Y
K
V
P
R
I
A
F
A
N
K
M
D
K
T
G
A
D
-----------
L
-----------
W
L
V
I
R
T
M
------------------------
Q
E
R
L
G
----
A
-----------------------------------------------------------------------
R
PVVM
Q
L
P
I
G
REDTFSGIIDVLRM
K
A
Y
T
Y
GNDL
G
T
D
I
R
E
I
P
IPEEY
L
D
Q
A
R
E
Y
H
E
K
L
V
E
V
A
A
D
F
D
E
N
I
M
L
K
Y
L
E
G
E
E
P
T
E
E
E
L
V
A
A
I
R
K
G
T
I
D
L
K
---
I
T
P
V
F
L
G
S
A
L
--------------------------------------------------------------------------------------------------------------------
K
N
-
K
G
-
V
Q
L
L
L
D
A
V
V
D
Y
L
P
S
P
L
D
IP
P
I
K
G
T
T
PEG
E
V
V
E
IHP---------
D
P
N
G
P
L
A
A
L
A
F
K
I
M
A
D
P
Y
-
V
G
R
L
T
F
I
R
V
Y
S
G
T
L
T
S
G
S
Y
V
Y
N
T
-
T
K
G
-----------------------
R
K
E
R
V
A
--
R
L
L
R
M
H
A
N
H
R
E
E
V
E
E
L
K
A
G
D
L
G
A
V
----
V
G
----
L
K
E
T
I
T
-
G
-
D
T
L
V
G
E
D
---
A
--
P
R-----
V
-
I
L
E
S
I
-
E
-
V
P
E
P
V
I
D
V
A
I
----
E
P
K
T
K
A
D
--
Q
E
---
K
L
S
Q
A
L
A
R
L
A
E
E
D
P
T
F
R
V
S
T
H
P
---
E
T
G
Q
---
T
I
I
S
G
M
G
E
L
H
L
E
I
I
V
D
R
L
K
R
E
F-
K
-
V
D
A
N
V
G
K
P
Q
V
A
Y
R
---------
E
T-
I
-----------------------------------------------------------------------------------------------------
T
K
P
V
D
V
E
G
K
F
I
R
QTGG
R
G
Q
Y
G
H
V
K
I
K
V
E
P
L
P
RGSG
F
E
F
V
N
AIVGGVIPKEY
I
P
A
V
Q
K
G
I
E
E
A
M
QSGPLIGFPV
V
D
I
K
V
T
LY
D
G
S
Y
A
EVDSS
E
M
A
F
K
I
A
G
S
M
A
I
K
E
A
V
Q
K
G
D
P
V
I
-----------
L
E
P
I
M
R
V
E
V
T
T
P
E
E
Y
M
G
D
V
I
G
D
L
N
A
R
R
G
-
Q
I
L
G
M
E
P
R
G
---
N
A
Q
V
I
R
A
F
V
P
L
A
E
-
M
F
-
G
Y
A
T
D
L
R
S
K
T
Q
G
R
G
S
F
V
M
F
F
D
H
--
Y
Q
E
V
P
K
Q
------------------------------------------------------------------------------------------------------------------------------------------------
89
HHSearch
54.56
27%
13
- C3 -
-
2XEX
-
EFG_STAAU
B:
[6-681]
--
S
L
E
K
T
R
N
I
G
I
M
A
H
I
D
A
G
K
T
T
T
T
E
R
I
L
Y
Y
T
G
R
I
H
K
I
G
---------
G
A
S
Q
M
D
W
M
E
Q
E
--------
S
A
A
T
T
A
A
W
E
------
G
H
R
V
N
I
I
D
T
P
G
H
V
D
F
T
V
E
V
E
R
S
L
R
V
L
D
G
A
V
T
V
L
D
A
Q
S
G
V
E
P
Q
T
E
T
V
W
R
Q
A
T
T
Y
G
V
P
R
I
V
F
V
N
K
M
D
K
L
G
A
N
-----------
F
-----------
E
Y
S
V
S
T
L
H
D
RLQANAAPI
Q
L
P
I
G
AEDEFEAI
I
D
L
V
E
M
K
C
F
K
-----------------------------------------------------------------------
Y
TNDL----------------------------
G
TE
I
E
E
I
E
IPEDH
L
D
R
A
E
E
A
R
A
S
L
I
E
A
V
A
E
T
S
D
E
L
M
E
K
Y
L
G
DEE
I
S
V
S
E
L
K
E
A
I
R
Q
A
T
T
N
V
E
---
F
Y
P
V
L
C
G
T
A
F
--------------------------------------------------------------------------------------------------------------------
K
N
-
K
G
-
V
Q
L
M
L
D
A
V
I
D
Y
L
P
S
P
L
D
VK
P
I
I
G
H
R
ASNPE
E
E
V
I
A
K
A-------
D
D
S
A
E
F
A
A
L
A
F
K
V
M
T
D
P
Y
-
V
G
K
L
T
F
F
R
V
Y
S
G
T
M
T
S
G
S
Y
V
K
N
S
-
T
K
G
-----------------------
K
R
E
R
V
G
--
R
L
L
Q
M
H
A
N
S
R
Q
E
I
D
T
V
Y
S
G
D
I
A
A
A
----
V
G
----
L
K
D
T
G
T
-
G
-
D
T
L
C
G
E
K
---
N
--
D
------
I
-
I
L
E
S
M
-
E
-
F
P
E
P
V
I
H
L
----
S
V
E
P
K
S
K
A
D
--
Q
D
---
K
M
T
Q
A
L
V
K
L
Q
E
E
D
P
T
F
H
A
H
T
--------
Q
---
V
I
I
G
G
M
G
E
L
H
L
D
I
L
V
D
R
M
K
K
E
F-
N
-
V
E
C
N
V
G
A
P
M
V
S
Y
R
---------
E
--
T
F
----------------------------------------------------------------------------------------------------
K
S
S
A
Q
V
Q
G
K
F
S
R
Q
SGG
R
G
Q
Y
G
D
V
H
I
E
F
T
P
N
E
TGA
G
F
E
F
E
N
AIVGGVVPREY
I
P
S
V
E
A
G
L
K
D
A
M
E
N
GVLAG
Y
P
L
I
D
V
K
A
K
L
Y
D
G
S
Y
H
DVDSS
E
M
A
F
K
I
A
A
S
L
A
L
K
E
A
A
K
K
CD
P
V
I
-----------
L
E
P
M
M
K
V
T
I
E
M
P
E
E
Y
M
G
D
I
M
G
D
V
T
S
R
R
G
-
R
V
D
G
M
E
P
R
G
---
N
A
Q
V
V
N
A
Y
V
P
L
S
E
-
M
F
-
G
Y
A
T
S
L
R
S
N
T
Q
G
R
G
T
Y
T
M
Y
F
D
H
--
Y
A
E
V
P
K
S
------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
52.95
25%
-30
- C3 -
-
3CB4
-
LEPA_ECOLI
A:
[1-555]
---
M
K
N
I
R
N
F
S
I
I
A
H
I
S
----
T
L
S
D
R
I
I
Q
I
C
G
-----------------------------
G
Q
S
V
T
L
D
Y
K
A
------
S
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
-----------
P
-----------
E
R
V
A
E
E
I
------------------------
E
D
I
V
-----
G
-----------------------------------------------------------------------
I
--------------------------------
D
-------------------------------------------
A
T
D
---------------------
A
V
R
C
S
A
K
T
G
V
---------------------------------------------------------------------------------------------------------------------
G
-
V
Q
D
V
L
E
R
L
V
R
D
I
P
P
P
E
G
---------------------------
D
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
D
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
----------
S
---------------
T
G
Q
T
Y
N
A
--
D
R
L
G
I
F
T
P
K
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
----
V
C
AIKD
I
H
G
A
P
V
-
G
-
D
T
L
T
L
A
R
---
N
PA
E
------
K
-
A
L
P
G
F
-
K
-
K
V
K
P
------
Q
V
Y
A
G
L
F
P
V
S
S
D
D
Y
E
A
F
R
D
A
L
G
K
L
S
---
L
N
D
A
S
L
F
Y
E
P
E
S
---
S
S
A
L
GFG
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y-
D
-
L
D
L
I
T
T
A
P
T
V
V
Y
E
V
E
T
TS
R
E
V
I
Y
--
V
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
S
P
S
KLPAVNNIY
E
L
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
-
N
--
Q
V
A
L
T
Y
E
I
P
M
A
E
-
V
V
L
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
D
M
V
R
V
D
V
L
I
N
G
E
R
V
D
----------------
A
L
-------
A
L
I
T
H
R
D
N
S
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
------------------------------------
P
R
Q
Q
F
-----------
D
I
A
I
Q
A
A
I
G
T
H
I
I
A
R
S
T
V
K
Q
L
R
K
N
V
L
A
K
C
Y
G
82
HHSearch
52.49
27%
-25
- C3 -
-
3DEG
-
LEPA_ECOLI
C:
[2-541]
----
K
N
I
R
N
F
S
I
I
A
H
I
D
H
G
K
S
T
L
S
D
R
I
I
Q
I
C
G
G
L
S
D
R
E
--------
M
E
A
Q
V
L
D
S
M
D
L
E
R
E
R
G
I
T
I
K
A
Q
S
V
T
L
D
Y
K
A
S
D
-
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
-----------
P
-----------
E
R
V
A
E
E
I
------------------------
E
D
I
V
--------------------------------------------------------------------------------------------------------------
G
-------------------------------------------
I
D
A
-------------------
T
D
A
V
R
C
S
A
K
--------------------------------------------------------------------------------------------------------------------
T
G
-
V
G
-
V
Q
D
V
L
E
R
L
V
R
D
I
P
P
P
E
G
---------------------------
D
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
D
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
T
-
G
-----------------------
Q
T
Y
N
A
D
--
R
L
G
I
F
T
P
-
K
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
VCAI
K
D
----
I
H
G
A
P
V
-
G
-
D
T
L
T
L
A
R
---
N
--
P
AE----
K
-
A
L
P
G
F
-
K
-
K
V
K
P
Q
V
Y
---
A
-
G
L
F
P
V
S
S
D
D
--
Y
E
---
A
F
R
D
A
L
G
K
L
S
L
N
D
A
S
L
F
Y
E
P
E
S
SSA
L
G
F
G
---
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y-
D
-
L
D
L
I
T
T
A
P
T
V
V
Y
E
---------
V
--
E
T----------------------------------------------------------------------------------------------------
T
SREVIYVDSPSKLPAVNNI-------------------------------------------------------------------------------------------
Y
E
L
-----------
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
---
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
-
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
---
D
M
V
--
R
V
D
V
L
I
N
GERVDALALITHRDNS
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
G
-
T
H
I
I
A
R
S
T
------------------------------------------------------------------------------
97
HHSearch
50.77
21%
-4
- C3 -
-
3JB9
-
SN114_SCHPO
B:
[137-924]
--
G
T
D
D
V
R
S
F
I
V
A
G
H
L
H
H
G
K
S
A
L
L
D
L
L
V
Y
Y
T
H
P
D
T
K
P
P
K------
R
R
S
L
R
Y
T
D
T
H
Y
L
E
R
E
R
V
M
S
I
K
S
T
P
L
T
L
A
V
S
D
M
-
K
G
K
T
F
A
F
Q
C
I
D
T
P
G
H
V
D
F
V
D
E
V
A
A
P
M
A
I
S
D
G
V
V
L
V
V
D
V
I
E
G
V
M
I
N
T
T
R
I
I
K
H
A
I
L
H
D
M
P
I
V
L
V
L
N
K
V
D
R
L
I
L
E
LRLP
P
N
D
A
Y
H
K
L
-----------
R
H
V
I
D
E
V
------------------------
N
D
N
I
C
----
Q
-----------------------------------------------------------------------
I
--------------------------------
S
KDLK
Y
R
-------------------------------------
V
S
P
--------------
E
---
L
G
N
V
C
F
A
S
C
D
L
G
Y
C
F
T
L
S
S
F
A
K
L
Y
I
D
R
H
GGID
V
D
L
F
S
K
R
LWGD
I
Y
F
D
SKTRKFAKQSLDGSGVR
S
F
V
H
F
I
L
E
P
L
Y
K
L
H
T
L
T
I
S
DE
A
E
K
L
K
K
H
L
S
S
---
F
Q
IYLK-----
P
K
D
Y
L
LDP
K
P
L
L
Q
L
I
C
A
S
F
-
F
G
F
P
V
G
F
V
N
A
V
T
R
H
I
P
S
P
R
E
N
A
A
R
K
A
S
Q
S
YIGPINS
S
I
G
K
A
I
L
E
MSR
E
E
S
A
P
L
V
M
H
V
T
K
L
Y
N
T
V
D
A
N
N
F
Y
A
F
A
R
V
Y
S
G
Q
V
K
K
G
Q
K
V
K
V
L
G
E
N
Y
SLEDEE
D
---------------
M
V
V
A
H
I
A
--
E
I
C
V
P
C
A
R
Y
R
L
H
V
D
G
A
V
A
G
M
L
V
L
L
----
G
G
----
V
D
N
S
I
S
-
K
T
A
T
I
V
S
D
N
LK
D
D
--
P
------
Y
-
I
F
R
P
I
A
H
-
M
S
E
S
V
F
K
V
----
A
V
E
P
H
N
P
S
E
--
L
P
---
K
L
L
D
G
L
R
K
T
N
K
S
Y
P
L
S
I
T
K
V
E
----
E
S
G
E
---
H
T
I
F
G
T
G
E
M
Y
M
D
C
L
L
Y
D
L
R
T
L
Y-
S
E
I
E
I
R
V
S
D
P
V
A
R
F
C
---------
E
T
-
A
V
D
TSS
I
K
C
F
S
D
T
PNKK
N
R
I
T
M
V
V
E
P
L
E
K
G
I
S
N
D
I
E
N
GKVNINWP
Q
K
R
I
S
E
F
F
Q
K
NYDWD
L
L
A
S
R
S
IWAFGPDDRGT
N
I
L
R
D
D
T
L
S
T
D
V
D
K
N
V
L
N
S
V
K
E
Y
I
K
Q
G
F
Q
W
G
T
REGPLCD
E
T
I
R
N
V
N
F
R
L
M
D
V
V
L
A
P
E
QIYRGGGQI
I
P
T
A
R
R
V
C
Y
S
S
F
L
T
A
S
------------------------------------------------------
P
R
L
-----------
M
E
P
V
Y
M
V
E
V
H
A
P
A
D
S
L
P
I
I
Y
D
L
L
T
R
R
R
G
-
H
V
L
Q
D
I
P
R
P
-
G
S
P
L
Y
L
V
R
A
L
I
P
V
I
D
-
S
C
-
G
F
E
T
D
L
R
V
H
T
Q
G
Q
A
M
C
Q
M
V
F
D
H
--
W
Q
V
V
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
50.69
26%
-44
- C3 -
-
3CB4
-
LEPA_ECOLI
C:
[2-547]
----
K
N
I
R
N
F
S
I
I
A
H
I
----
S
T
L
S
D
R
I
I
Q
I
C
G
G
----------------------------------
Q
S
V
T
L
D
Y
K
A
S
-
D
G
E
T
Y
Q
L
N
F
I
D
T
P
G
H
V
D
F
S
Y
E
V
S
R
S
L
A
A
C
E
G
A
L
L
V
V
D
A
G
Q
G
V
E
A
Q
T
L
A
N
C
Y
T
A
M
E
M
D
L
E
V
V
P
V
L
N
K
I
D
L
P
A
A
D
-----------
P
-----------
E
R
V
A
E
E
I
------------------------
E
D
I
V
--------------------------------------------------------------------------------------------------------------
G
-------------------------------------------
I
D
A
-------------------
T
D
A
V
R
C
S
A
K
--------------------------------------------------------------------------------------------------------------------
T
G
-
V
G
-
V
Q
D
V
L
E
R
L
V
R
D
I
P
P
P
E
G
---------------------------
D
P
E
G
P
L
Q
A
L
I
I
D
S
W
F
D
N
Y
-
L
G
V
V
S
L
I
R
I
K
N
G
T
L
R
K
G
D
K
V
K
V
M
S
T
-
G
-----------------------
Q
T
Y
N
A
D
RL
G
I
F
T
P
K
---
Q
V
D
R
T
E
L
K
C
G
E
V
G
W
L
VCAI
K
D
----
I
H
G
A
P
V
-
G
-
D
T
L
T
L
A
R
---
N
--
P
AE----
K
-
A
L
P
-----
G
F
K
K
V
K
P
Q
V
Y
A
-
G
L
F
P
V
S
S
D
D
--
Y
E
---
A
F
R
D
A
L
G
K
L
S
L
N
D
A
S
L
F
Y
E
P
E
S
SSA
L
G
F
G
---
F
R
C
G
F
L
G
L
L
H
M
E
I
I
Q
E
R
L
E
R
E
Y-
D
-
L
D
L
I
T
T
A
P
T
V
V
Y
E
---------
V
--
E
T----------------------------------------------------------------------------------------------------
T
SREVIYVDSPSKLPAVNNI-------------------------------------------------------------------------------------------
Y
E
L
-----------
R
E
P
I
A
E
C
H
M
L
L
P
Q
A
Y
L
G
N
V
I
T
L
C
V
E
K
R
G
-
V
Q
T
N
M
V
Y
H
G
---
N
Q
V
A
L
T
Y
E
I
P
M
A
E
V
V
L
-
D
F
F
D
R
L
K
S
T
S
R
G
Y
A
S
L
D
Y
N
F
K
R
--
F
Q
A
S
---
D
M
V
--
R
V
D
V
L
I
N
GERVDALALITHRDNS
Q
N
R
G
R
E
L
V
E
K
M
K
D
L
I
P
R
Q
Q
F
D
I
A
I
Q
A
A
I
G
-
T
H
I
I
A
R
S
T
---------------
V
K
Q
L
R
K
---------------------------------------------------------
83
HHSearch
50.12
67%
-63
* C5 *
-
4ZCK
-
TYPA_ECOLI
A:
[33-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
M
R
A
S
-
T
D
E
A
V
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
A
N
R
A
--
88
HHSearch
49.86
24%
25
- C3 -
-
2DY1
1
?
A:
[6-652]
---
G
A
M
I
R
T
V
A
L
V
G
H
A
G
S
G
K
T
T
L
T
E
A
L
L
Y
K
T
G
A
K
E
R
R
G
R
V-----
E
E
G
T
T
T
T
D
Y
T
P
E
A
K
L
H
R
T
T
V
R
T
G
V
A
P
L
L
F
R
------
G
H
R
V
F
L
L
D
A
P
G
Y
G
D
F
V
G
E
I
R
G
A
L
E
A
A
D
A
A
L
V
A
V
S
A
E
A
G
V
Q
V
G
T
E
R
A
W
T
V
A
E
R
L
G
L
P
R
M
V
V
V
T
K
L
D
K
G
G
-
D
-----------
Y
-----------
Y
A
L
L
E
D
L
------------------------
R
S
T
L
G
----
P
ILPI
D
L
P
L
Y
E
GGKWVGLIDVFHG
K
A
Y
R
Y
E
NG
E
E
R
E
A
E
VPPEE
R
E
R
V
Q
R
F
R
Q
E
V
L
E
A
I
V
E
T
D
E
G
L
L
E
K
Y
L
E
G
E
--------------------------------
E
-------------------------------------------
V
T
G
E
A
L
E
K
A
F
H
E
A
V
R
R
G
L
---
L
Y
P
V
A
L
A
S
G
E
--------------------------------------------------------------------------------------------------------------------
R
E
-
I
G
-
V
L
P
L
L
E
L
I
L
E
A
L
P
S
P
T
E
R--------------------------
F
G
D
G
P
P
L
A
K
V
F
K
V
Q
V
D
P
F
-
M
G
Q
V
A
Y
L
R
L
Y
R
G
R
L
K
P
G
D
S
L
Q
S
E
-
A
-------------------------
G
Q
V
R
L
P
--
H
L
Y
V
P
M
G
K
D
L
L
E
V
E
E
A
E
A
G
F
V
L
G
V
----
P
K
----
A
E
G
L
H
R
-
G
-
M
V
L
W
Q
G
E
---
K
--
P
ES----
E
-
E
V
P
F
A
-
R
-
L
P
D
P
N
V
P
V
A
L
----
H
P
K
G
R
T
D
--
E
A
---
R
L
G
E
A
L
R
K
L
L
E
E
D
P
S
L
K
L
E
R
Q
E
---
E
T
G
E
---
L
L
L
W
G
H
G
E
L
H
L
A
T
A
K
E
R
L
Q
D
Y
--
G
-
V
E
V
E
F
S
V
P
K
V
P
Y
R
---------
E
T
-
I
-----------------------------------------------------------------------------------------------------
K
K
V
A
E
G
Q
G
K
Y
K
K
Q
T
GG
H
G
Q
Y
G
D
V
W
L
R
L
E
P
A
S
E
Y
G
F
E
W
RITGGVIPSKY
Q
E
A
I
E
E
G
I
K
E
A
A
KKGVLAGFPVMG
F
K
A
I
VY
N
G
S
Y
H
EVDSS
D
L
A
F
Q
I
A
A
S
L
A
F
K
K
V
M
A
E
AH---
P
V
L
-----------
L
E
P
I
Y
R
L
K
V
L
A
P
Q
E
R
V
G
D
V
L
S
D
L
Q
A
R
R
G
-
R
I
L
G
M
E
Q
E
G
---
A
L
S
V
V
H
A
E
V
P
L
A
E
-
V
L
-
E
Y
Y
K
A
L
P
G
L
T
G
G
A
G
A
Y
T
L
E
F
S
H
--
Y
A
E
V
P
P
H
------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
49.77
69%
-66
- C5 -
-
4ZCK
-
TYPA_ECOLI
A:
[35-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
S
M
F
F
C
V
N
T
S
P
F
C
G
K
E
G
K
F
V
T
S
R
Q
I
L
D
R
L
N
K
E
L
V
H
N
V
A
L
R
V
E
E
T
E
---
D
A
D
A
---
F
R
V
S
G
R
G
E
L
H
L
S
V
L
I
E
N
M
R
R
E
--
G
-
F
E
L
A
V
S
R
P
K
V
I
F
R
---------
E
--
I
-----------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------
G
R
K
-----------
Q
E
P
Y
E
N
V
T
L
D
V
E
E
Q
H
Q
G
S
V
M
Q
A
L
G
E
R
K
G
-
D
L
K
N
M
N
P
D
G
-
K
-
G
R
V
R
L
D
Y
V
I
P
S
R
G
-
L
I
-
G
F
R
S
E
F
M
T
M
T
S
G
T
G
L
L
Y
S
T
F
S
H
--
Y
D
D
V
R
P
G
E
V
G
Q
R
Q
N
G
V
L
I
S
----------------
N
G
Q
G
K
A
V
A
F
A
L
F
G
L
Q
D
R
G
K
L
F
L
G
H
G
A
E
V
Y
E
G
Q
I
I
G
-
I
H
S
R
S
N
D
L
T
V
N
C
L
T
G
K
K
L
T
N
M
R
A
S
-
T
D
E
A
V
V
L
V
P
P
I
R
M
T
L
E
Q
A
L
E
F
I
D
D
D
E
L
V
E
V
T
P
T
S
I
R
I
R
K
R
H
L
T
E
N
D
R
R
R
------
95
HHSearch
49.52
22%
9
- C3 -
-
5LJ3
-
SN114_YEAST
C:
[130-943]
---
P
E
R
I
I
N
V
G
V
I
G
P
L
H
S
G
K
T
S
L
M
D
L
L
V
I
D
S
H
K
R
I
P
D
M
SKNVELG
W
K
P
L
R
Y
L
D
N
L
K
Q
E
I
D
R
G
L
S
I
K
L
N
G
S
T
L
L
C
T
D
L
E
-
S
K
S
R
M
I
N
F
L
D
A
P
G
H
V
N
F
M
D
E
T
A
V
A
L
A
A
S
D
L
V
L
I
V
I
D
V
V
E
G
V
T
F
V
V
E
Q
L
I
K
Q
S
I
K
N
N
V
A
M
C
F
V
I
N
K
L
D
R
L
I
L
D
-----------
L
KLPPMDAYLKL
N
H
I
I
A
N
I
------------------------
N
S
F
T
K
----
G
-----------------------------------------------------------------------
N
--------------------------------
V
-------------------------------------------
F
S
P
I
-----------------
D
N
N
I
I
F
A
S
T
K
L
G
F
T
F
T
--
I
KEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSN
F
R
VNLSQEALQ
Y
DPQPFLKHVLQ-----
L
I
F
R
Q
-
Q
T
G
L
V
D
A
I
T
R
C
Y
Q
-
P
F
E
LFDNKTAHLSIPGKS------------
T
P
E
G
T
L
W
A
H
V
L
K
T
V
D
Y
-
G
-
G
A
E
W
S
L
V
R
I
Y
S
G
L
L
K
R
G
D
T
V
R
I
L
D
T
S
Q
------
S
ESRQKRQLHDIEDDE
T
P
S
C
E
V
E
--
E
I
G
L
L
G
G
R
Y
V
Y
P
V
H
E
A
H
K
G
Q
I
V
L
I
----
K
G
----
I
S
S
A
Y
I
K
S
-
A
T
L
Y
S
V
K
---
S
--
K
EDMKQL
K
-
F
F
K
P
L
-
D
Y
I
T
E
A
V
F
K
----
I
V
L
Q
P
L
L
P
R
E
--
L
P
---
K
L
L
D
A
L
N
K
I
S
K
Y
Y
P
G
V
I
I
K
V
E
----
E
S
G
E
---
H
V
I
L
G
N
G
E
L
Y
M
D
C
L
L
Y
D
L
R
A
S
YA
K
-
I
E
I
K
I
S
D
P
L
T
V
F
S
---------
E
SC
S
NESFASIPVSNISVAAEPMDSKMIQDLSRPRKLSKILRTEYGWDSLASRNVWSFYNLINDTLPDEISPELLSKYKEQII----------------------
Q
GFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQIIPLMKKACYVGLLTAI-----------------------------------------------------
P
I
L
-----------
L
E
P
I
Y
E
V
D
I
T
V
H
A
P
L
L
P
I
V
E
E
L
M
K
K
R
R
G
S
R
I
Y
K
T
I
K
V
A
G
T
-
P
L
L
E
V
R
G
Q
V
P
V
I
E
-
S
A
-
G
F
E
T
D
L
R
L
S
T
N
G
L
G
M
C
Q
L
Y
F
W
H
KI
W
R
K
V
P
G
D
------------------------------------------------------------------------------------------------------------------------------------------------