@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRL7: (2017-12-03 )
MIREILLADTHNYYGILDERFIDLAHQFSRLQDARTGQGGAALAVYFRGQKVVDIYTGLKSQTEAWQPDTLAVCYSTGKGVLATLAHILVSEGFLEYDKPIATYWPEFAQNGKEQMTLRHVLSHQSGMFDVRNIIESAREMLDWSHMLVVVAATKPRFLAGEGNAYQALTFGWLVGGVLEKATGQSLDQLMQNYLVEPLQLDGAYFGTPANELDRVARLIIQPKPEKPASTQVEKPKKPQTRKSSLSEKVITWTGQDPQDFQDAMIPKGMKNFSFFSDEGLQAVIPAANGTFTANSLAKIYAMLANQGEWDGQQLIRPEVFKELSTIQSYARDRVMPIPMNWRLGYHRIITMGKRAKNGFGHIGYNGSGAWCDPERDLSFAYTHNLQIGSITGDYRLWGLTQEALRCTDQILKGRKGWF
Atome Classification :
(20 SA)
----------------------------------.........10........20........30...-.....40......-..50........--60-..-------.......70........80........90........100.......----110-----------------........120.....-.-.130.....---------.----------.140---..-----------..-...-.------------.150..--.....160.......170.-......180.......190.......200..--.....210..--..-.-...220......-.230.......240.-......250.......260.......270.......280.......290.......300-.......--.310........320.......330.--------.-------------------..--...340.-.....---.350.--.----------------------------.----.....360----....-----..---.---..370.......380.......390-.......400.......410.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
----------------------------------M
I
R
E
I
L
L
ADTH
N
Y
Y
G
I
L
D
E
R
F
I
D
L
A
H
Q
F
S
R
L
Q
DA-RTGQG
G
A
A
L
A
V
Y
F-RG
Q
K
V
V
D
I
Y
TGL--K--SQ-------TEAWQP
D
T
L
A
V
C
YSTG
K
G
V
L
A
T
L
A
H
I
L
V
S
E
G
F
L
E
YDK
P
I
A
T
Y
W
P
E
F
A
----QN------------------
G
K
E
Q
M
T
L
R
H
V
L
S
HQSG-
M
-
F
D
V
R
N
I
I
E
S
---------
A
----------
R
E
-----
M
L-----------DW-S
H
M
-
L
------------
V
V
V
AAT--K
P
R
F
L
AGEGNA
Y
Q
A
L
T
F
G
W
-
L
V
G
G
V
L
E
KA
T
G
Q
S
L
D
Q
L
M
Q
N
YLVE
P
L
QLDGA--YFGT
P
A
N
-
E
L
--
D
R
-
V
-
A
R
L
I
IQPKPEKP-ASTQVEKPKKP
Q
T
R
K
-SSLSE
K
V
I
T
WTGQ
D
P
Q
D
F
Q
D
A
M
IPKGMKNFSFFSDEG
L
Q
A
V
IPAANGTF
T
A
N
S
L
A
K
I
Y
--
A
M
L
ANQG--EW-D
G
Q
QLI
R
P
E
V
F
K
E
L
S
T
I
Q
S
Y
A
RD--------R-------------------VM--PIPMNWR-LG
Y
H
R
---
I
I
T-M--G----------------------------K----RAKNGF------GHIG-----YN---G---SGAWCDPERD
L
S
F
A
Y
T
H
N
L
Q
I
G
S
I
T-GDY
R
L
W
G
L
T
Q
E
A
L
R
C
T
D
Q
I
L
KGRKGWF
1
PsiBlast_PDB
85.29
31%
-12
- C3 -
-
5GKV
-
?
A:
[18-382]
------------------------------------------------
G
V
C
P
D
R
F
A
A
V
R
E
V
F
E
Q
-
N
F
A
-
D
G
G
E
L
G
A
R
F
A
F
A
I
-
E
G
E
V
V
V
D
L
M
G
G
F
AD
R
--
K
R
-------
Q
V
P
F
G
P
D
T
L
T
A
L
F
S
T
T
K
A
V
A
A
L
L
I
A
R
L
V
D
E
G
R
L
A
Y
D
Q
A
V
A
D
V
W
P
E
F
A
----
Q
A
------------------
G
K
D
A
V
T
V
E
Q
A
L
S
H
Q
A
G
-
L
-
S
G
F
P
D
E
T
D
P
---------
A
----------
I
------
W
F
-----------
D
W
-
D
A
T
-
C
------------
A
K
L
A
A
M
--
A
P
L
F
P
I
G
S
A
S
G
Y
H
P
V
T
Y
G
Y
-
L
A
G
E
I
F
R
R
V
D
G
R
T
M
G
T
A
L
R
E
D
I
C
E
P
L
G
L
D
-
L
--
W
I
G
L
P
D
S
-
E
H
--
D
R
-
V
-
A
D
L
M
------
R
P
-
T
A
M
----
P
Q
F
G
E
I
N
P
-
A
V
E
A
A
F
F
K
P
W
S
S
-----------
P
--
K
G
-----
A
A
E
W
R
R
V
E
I
P
S
A
N
G
H
A
T
A
P
A
L
A
R
L
M
--
G
A
L
A
H
G
G
--
T
L
-
D
G
R
S
L
I
T
P
A
G
I
K
A
A
T
A
E
R
L
R
G
R
D
--------
L
-------------------
V
L
--
P
Y
E
I
S
W
G
-
A
G
F
M
R
NEP
N
F
Y
-
Y
--
G
----------------------------
P
----
T
A
E
-
A
F
------
G
H
S
G
-----
W
G
---
G
---
S
C
A
F
A
D
P
T
R
G
V
S
G
A
Y
V
M
N
K
Q
G
N
A
L
I
-
G
D
P
R
S
V
R
L
I
E
A
A
---------------
24
HHSearch
83.91
30%
-26
- C3 -
-
5GKV
-
?
A:
[14-386]
--------------------------------------------
T
D
I
T
G
V
C
P
D
R
F
A
A
V
R
E
V
F
E
Q
N
F
A
D
G
G
--
E
L
G
A
R
F
A
F
A
I
-
E
G
E
V
V
V
D
L
M
G
G
F
--
A
--
D
R
KR-----
Q
V
P
F
G
P
D
T
L
T
A
L
F
S
T
T
K
A
V
A
A
L
L
I
A
R
L
V
D
E
G
R
L
A
Y
D
Q
A
V
A
D
V
W
P
E
F
A
----
Q
A
------------------
G
K
D
A
V
T
V
E
Q
A
L
S
H
Q
A
G
-
L
-
S
G
F
P
-
D
E
T
D
---------
P
----------
A
I
-----
W
F
-----------
D
W
-
D
A
T
-
C
------------
A
K
L
A
A
M
--
A
P
L
F
P
I
G
S
A
S
G
Y
H
P
V
T
Y
-
G
Y
L
A
G
E
I
F
R
R
V
D
G
R
T
M
G
T
A
L
R
E
D
I
C
E
P
L
G
L
D
L
W
--
I
G
L
P
D
S
E
--
H
--
D
R
-
V
-
A
D
L
M
R
P
--
T
A
M
--
P
Q
F
G
E
I
N
P
A
V
E
A
------------
A
F
F
------------
K
P
W
S
S
P
--
K
G
A
A
E
W
R
R
V
E
I
P
S
A
N
G
H
A
T
A
P
A
L
A
R
L
M
--
G
A
L
A
H
G
G
--
T
L
D
G
R
-
S
L
I
T
P
A
G
I
K
A
A
T
A
E
R
L
R
G
R
D
--------
L
-------------------
V
L
--
P
Y
E
I
S
W
G
-
A
G
F
M
R
---
N
E
P
-
N
--
F
YY--------------------------
G
----
P
T
A
E
A
F
------
G
H
S
G
-----
W
G
---
G
---
S
C
A
F
A
D
P
T
R
G
V
S
G
A
Y
V
M
N
K
Q
G
N
A
L
I
-
G
D
P
R
S
V
R
L
I
E
A
A
Y
A
S
L
-----------
2
PsiBlast_PDB
72.46
24%
-63
- C3 -
-
3ZYT
-
?
A:
[29-343]
---------------------------------------------------------------------------
A
Q
V
A
A
Y
H
-
R
G
V
K
V
L
D
L
S
G
G
P
--
H
--------------
I
R
P
D
S
V
T
G
V
F
S
C
S
K
G
M
A
G
L
V
M
A
L
L
V
Q
D
G
E
L
D
L
E
A
E
V
V
K
Y
W
P
E
F
G
----
V
E
------------------
G
K
S
S
I
T
V
A
Q
L
L
S
H
R
A
G
-
L
-
L
G
V
E
G
G
L
-
T
---------
L
----------
H
E
-----
V
N
-----------
N
S
-
E
L
A
-
A
------------
A
K
L
A
E
L
--
P
P
L
W
K
P
G
T
A
F
G
Y
H
A
L
T
I
G
I
-
F
M
E
E
L
C
R
R
I
T
G
S
T
L
Q
E
V
F
E
Q
R
I
---
R
A
V
T
G
A
NF
Y
L
G
L
P
E
S
-
E
E
--
S
R
-
F
-
A
Q
F
R
W
A
A
D
P
S
W
P
-
W
-------
V
D
P
A
S
H
F
-
G
L
A
A
N
A
A
V
G
-------
D
I
L
D
------
L
P
N
I
R
E
V
R
A
A
G
L
S
----
S
A
A
G
V
A
S
A
E
G
M
A
R
I
Y
A
A
A
L
T
G
L
E
G
--
K
S
-
A
M
P
P
L
L
T
E
E
T
I
R
T
V
S
A
E
Q
V
F
G
I
D
--------
R
-------------------
V
F
--
G
E
T
G
C
F
G
-
T
V
F
M
K
---
S
H
T
R
M
--
P
----------------------------
F
----
G
S
Y
R
A
F
------
G
H
D
G
-----
A
S
---
A
---
S
L
G
F
A
D
P
V
Y
E
L
G
F
G
Y
V
-------------------------------------
23
HHSearch
72.20
22%
-29
- C3 -
-
3ZYT
-
?
A:
[4-370]
------------------------------------------------
Q
V
I
A
P
G
F
E
P
V
A
E
L
F
G
V
F
L
E
Q
D
P
--
D
Y
S
A
Q
V
A
A
Y
H
-
R
G
V
K
V
L
D
L
S
G
G
----------------
P
H
I
R
P
D
S
V
T
G
V
F
S
C
S
K
G
M
A
G
L
V
M
A
L
L
V
Q
D
G
E
L
D
L
E
A
E
V
V
K
Y
W
P
E
F
G
----
V
E
------------------
G
K
S
S
I
T
V
A
Q
L
L
S
H
R
A
G
-
L
-
L
G
V
E
-
G
G
L
T
---------
L
----------
H
E
-----
V
N
-----------
N
S
-
E
L
A
-
A
------------
A
K
L
A
E
L
--
P
P
L
W
K
P
G
T
A
F
G
Y
H
A
L
T
I
-
G
I
F
M
E
E
L
C
R
R
I
T
G
S
T
L
Q
E
V
F
E
Q
R
I
R
A
V
T
G
A
N
F
Y
--
L
-
G
L
P
E
S
-
E
E
--
S
R
-
F
-
A
Q
F
R
W
A
--
A
D
P
S
W
P
W
V
D
P
A
S
H
F
--------------
G
-
L
A
A
N
A
A
---
V
----
G
D
I
L
D
--
L
P
N
I
R
E
V
R
A
A
G
L
S
S
A
A
G
V
A
S
A
E
G
M
A
R
I
Y
--
A
A
A
L
T
G
L
EG
K
S
A
M
P
-
P
L
L
T
E
E
T
I
R
T
V
S
A
E
Q
V
F
G
I
D
--------
R
-------------------
V
F
--
G
E
T
G
C
F
G
-
T
V
F
M
K
---
S
H
T
-
R
M-
P
----------------------------
F
----
G
S
Y
R
A
F
------
G
H
D
G
-----
A
S
---
A
---
S
L
G
F
A
D
P
V
Y
E
L
G
F
G
Y
V
P
Q
T
A
E
P
G
G
V
--
G
C
R
N
F
Q
L
S
S
A
V
R
E
V
I
A
G
F
--------
40
HHSearch
60.91
19%
11
- C3 -
-
4IVK
1
?
A:
[36-425]
----------------------------------------------
E
A
G
F
T
S
E
G
L
A
R
I
D
A
Y
L
K
N
E
I
Q
A
K
T
--
M
P
G
A
V
M
M
I
K
R
-
N
G
E
T
A
Y
F
S
S
F
G
L
--
R
--
D
P
DT-----
K
E
P
M
T
A
E
T
I
F
R
I
Y
S
M
S
K
P
I
T
T
V
A
A
M
M
L
V
E
E
G
K
L
Q
L
D
E
P
V
S
K
Y
I
P
S
F
A
----
N
V
K
V
G
V
E
T
K
G
EN
G
M
A
L
E
T
G
P
V
K
R
A
I
T
I
Q
D
L
M
R
H
T
S
G
-
I
-
T
Y
G
F
V
G
D
G
L
---------
V
K
K
A
Y
I
A
S
NLF
D
G
-----
D
F
-----------
D
N
-
A
E
F
-
A
------------
E
R
I
A
K
L
--
P
L
V
Y
Q
P
G
T
T
W
D
Y
G
H
-
S
T
-
D
-
I
L
G
R
V
V
E
V
V
S
G
K
S
L
Y
Q
F
E
K
E
R
L
L
D
P
L
G
M
K
D
T
--
G
F
Y
V
T
D
P
-
A
K
--
K
S
L
V
-
A
E
A
M
P
N
--
D
R
K
---------------------------
I
G
------------
G
S
E
M
F
----
D
P
R
V
Q
K
K
W
E
P
G
G
Q
G
M
V
S
T
I
G
D
Y
A
R
F
T
--
Q
M
V
L
N
G
G
--
T
L
D
G
K
-
R
Y
L
S
P
K
T
I
A
Y
M
G
S
N
H
I
P
Q
A
S
--------
G
I
V
P
G
AYY------------
L
P
--
G
P
G
V
G
F
G
-
L
G
F
A
V
---
R
T
E
-
A
--
G
VTP
V
------------------------
E
----
G
S
V
G
D
L
------
S
W
G
G
-----
A
G
---
G
---
T
V
F
W
I
D
P
K
E
N
L
T
V
V
F
M
A
P
M
V
S
P
R
A
----
R
V
W
R
T
L
R
N
I
V
Y
G
A
F
D
----------
26
HHSearch
56.84
17%
-29
- C3 -
-
4P6B
-
?
A:
[3-388]
-------------------------------------------------------
D
L
L
T
N
V
A
E
N
Y
V
N
Q
D
L
--
F
A
G
I
E
W
R
I
D
Q
-
D
G
K
P
I
F
Q
G
C
A
G
V
--
K
--
D
I
ET-----
R
T
F
I
P
K
N
A
I
Y
R
I
Y
S
M
T
K
P
I
V
S
F
L
A
M
M
L
I
E
R
G
V
F
R
L
S
S
P
I
Q
N
F
D
P
R
F
K
----
S
M
K
V
I
D
QHA
H
I
E
P
-------
A
T
A
L
I
T
I
E
H
L
L
T
H
Q
A
G
-
F
-
S
Y
D
F
S
L
G
C
P
I
S
A
H
-----
Y
R
D
A
QLIE---
D
G
-----
G
R
-----------
D
L
-
T
D
M
-
M
------------
G
V
L
A
E
L
--
P
L
V
F
H
P
G
T
Q
W
K
Y
S
I
-
S
T
-
D
-
V
L
A
H
I
I
E
C
A
T
G
E
R
V
D
D
L
L
Q
R
L
I
F
D
P
L
D
M
Q
D
T
--
G
F
S
L
P
L
D
-
G
A
--
S
R
-
L
-
M
E
V
Y
G
M
-------
G
L
P
A
L
K
-
P
-----------
A
P
--
H
V
L
V
-------------
P
A
D
L
-
G
S
S
H
P
T
D
D
P
D
F
R
R
G
G
H
G
L
Y
S
T
L
D
D
Y
M
A
F
A
--
N
M
L
L
S
G
Q
--
T
P
E
G
E
-
T
L
L
S
P
A
V
L
K
L
A
L
A
P
R
V
H
F
G
A
--------
R
GM-----------------
R
I
--
N
D
E
P
F
A
G
-
Y
S
W
N
L
---
L
G
R
-
V
MT
D
----------------------------
V
----
G
A
A
A
Y
A
THLG
E
F
G
W
S
G
-----
A
A
---
A
---
T
Y
F
W
V
D
P
T
K
N
M
T
G
C
V
M
T
Q
F
L
G
S
Q
H
----
P
I
G
S
D
M
Q
A
A
A
M
S
M
L
-----------
33
HHSearch
55.40
20%
-15
- C3 -
-
5TGF
2
?
B:
[7-314]
---------------------------------------------------
T
Y
D
F
T
P
L
D
S
I
I
S
S
W
M
D
K
G
Y
--
Y
P
G
G
A
I
C
V
V
K
-
N
D
S
V
L
F
E
K
A
Y
G
S
-----------------
F
T
G
D
T
K
V
Y
V
A
S
A
G
K
W
V
A
A
A
V
I
G
A
V
V
D
R
T
D
L
S
W
D
D
P
V
E
K
W
L
P
Q
F
R
----
G
D
------------------
A
K
G
G
I
L
L
R
Q
L
L
S
H
T
S
G
-
V
-
R
P
Y
L
-
P
A
P
R
---------
V
----------
D
N
-----
Y
N
-----------
H
L
-
D
S
A
-
V
------------
T
E
I
L
S
L
--
D
T
V
F
T
P
G
T
R
F
E
Y
G
G
L
A
M
-
Q
-
I
A
G
R
M
A
E
V
A
M
G
K
E
F
E
P
L
F
Q
E
L
I
A
A
P
L
G
M
T
H
S
--
H
F
A
P
V
N
T
-
D
-------------------------------------------------------------------------
G
G
H
A
P
M
L
G
G
G
L
C
T
T
L
N
D
Y
I
R
F
L
--
K
M
I
Y
H
N
G
--
R
S
G
N
R
-
E
I
L
K
P
E
T
V
Q
T
M
Q
A
D
Q
V
R
N
A
V
VAPGEYVE
K
-------------------
A
L
GQ
H
H
T
S
I
Y
G
-
L
G
E
W
R
---
E
L
V
-
D
--
E
A---------------------------
T
----
G
E
A
Y
Q
I
------
S
S
P
G
-----
W
A
---
G
---
A
Y
P
W
I
N
K
R
D
G
V
Y
G
F
F
I
A
H
V
Q
G
E
A
------------------------------
38
HHSearch
54.62
17%
-38
- C3 -
-
5CHU
-
?
A:
[7-347]
---------------------------------------------------
A
P
L
T
A
T
V
D
G
I
I
Q
P
M
L
K
A
Y
R
--
I
P
G
M
A
V
A
V
L
K
-
D
G
K
A
H
Y
-
F
N
Y
G
V
--
A
--
N
R
ES-----
G
Q
R
V
S
E
Q
T
L
F
E
I
G
S
V
S
K
T
L
T
A
T
L
G
A
Y
A
A
V
K
G
G
F
E
L
D
D
K
V
S
Q
H
A
P
W
L
K
----
G
S
------------------
A
F
D
G
V
T
M
A
E
L
A
T
Y
S
A
G
G
L
-
P
L
Q
F
-
P
D
-----------------------
E
-----
V
D
-----------
S
N
-
D
K
M
-
Q
------------
T
Y
Y
R
S
W
--
S
P
V
Y
P
A
G
T
H
R
Q
Y
S
N
P
S
I
-
G
-
L
F
G
H
L
A
A
N
S
L
G
Q
P
F
E
Q
L
M
S
Q
T
L
L
P
K
L
G
L
H
H
T
--
Y
I
Q
V
P
E
S
-
A
M
--
A
N
-
Y
-
A
Y
G
Y
S
K
--
E
D
K
------------------------------------------
P
I
------
R
A
-
T
P
G
V
L
A
A
E
A
Y
G
I
K
T
G
S
A
D
L
L
K
F
V
--
E
A
N
M
G
Y
Q
--
G
---
D
-
A
A
L
K
S
A
-
I
A
L
T
H
T
G
F
H
S
-----------------------------------
V
G
E
M
T
Q
G
-
L
G
W
E
S
---
Y
D
Y
-
P
--
V
T
E
Q
V
L
L
A
G
N
SPAVSF
Q
A
N
P
V
TRFA
V
P
K
A
M
----
G
E
Q
R
L
Y
------
N
K
T
G
-----
S
T
GG
F
G
---
A
Y
V
A
F
V
P
A
R
G
I
A
I
V
M
L
A
N
R
N
Y
P
I
E
-----------------------------
47
Fugue
54.15
17%
-3
- C3 -
-
1WYC
-
NYLC_FLASK
A:
[5-392]
STGQHPARYPGAAAGEPTLDSWQEP
P
H
N
R
W
A
F
A
H
L
G
E
M
V
P
S
A
A
V
S
R
R
P
G
H
A
L
A
R
L
G
A
I
A
A
Q
L
P
D
L
E
Q
R
-
L
E
Q
T
Y
T
D
A
F
L
V
L
R
-
G
T
E
V
V
A
E
Y
Y
R
A
-----------------
G
F
A
P
D
D
R
H
L
L
M
S
V
S
K
S
L
C
G
T
V
V
G
A
L
V
D
E
G
R
I
D
P
A
Q
P
V
T
E
Y
V
P
E
L
A
----
G
S
------------------
V
Y
D
G
P
S
V
L
Q
V
L
D
M
Q
I
S
-
I
-
D
Y
N
E
D
Y
V
D
P
---------
A
----------
S
E
-----
V
Q
-----------
T
H
-
D
R
S
-
A
GWRTRRHGDPAD
T
Y
E
F
L
T
--
T
L
R
G
D
G
S
T
G
E
F
Q
Y
C
S
A
N
T
D
-
V
L
A
W
I
V
E
R
V
T
G
L
R
Y
V
E
A
L
S
T
Y
L
W
A
K
L
------------------------------------------------------------------------------
D
A
D
R
D
A
T
I
T
V
D
T
T
G
F
G
F
A
N
G
G
V
S
C
T
A
R
D
L
A
R
V
G
--
R
M
M
L
D
G
G
--
V
A
-
P
G
G
R
V
V
S
E
D
W
V
R
R
V
L
A
G
G
S
H
E
A
M
--------
T
-------------------
D
K
--
G
F
T
N
T
F
P
D
G
S
Y
T
R
---
Q
W
W
-
C
--
T
----------------------------
G
----
N
E
R
G
N
V
------
S
G
I
G
-----
I
H
---
G
---
Q
N
L
W
L
D
P
L
T
D
S
V
I
V
K
L
S
S
W
P
D
P
D
----
T
E
H
W
H
R
L
Q
N
G
I
L
L
D
V
S
R
A
L
D
A
V
----
35
HHSearch
54.12
17%
-28
* C3 *
-
2QZ6
-
AMPC_PSEFL
A:
[8-360]
-----------------------------------------------------
I
R
Q
V
V
D
S
T
V
E
P
L
M
Q
Q
Q
D
--
I
A
G
L
S
V
A
V
I
Q
-
N
G
K
A
Q
Y
F
-
N
Y
G
V
--
A
--
N
K
DS-----
K
Q
P
I
T
E
N
T
L
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
A
N
G
K
L
K
L
S
D
P
A
S
Q
Y
L
P
A
L
R
----
G
D
------------------
K
F
D
H
I
S
L
L
N
L
G
T
Y
T
A
G
-
G
-
L
P
L
Q
-
F
P
-------------------------------------------
T
-
G
K
M
-
I
------------
S
Y
Y
Q
H
W
--
K
P
A
F
A
P
G
T
Q
R
L
Y
S
N
P
S
I
-
G
-
L
F
G
H
L
A
A
Q
S
L
G
Q
P
F
E
K
L
M
E
Q
T
V
L
P
K
L
G
L
K
H
T
--
F
I
S
V
P
E
T
-
Q
M
--
S
L
-
Y
-
A
Q
G
Y
D
K
--
A
G
K
---------
P
-------------------------------
V
R
-------
V
S
--
P
G
A
L
D
A
E
A
Y
G
I
K
T
S
T
S
D
L
I
H
Y
V
--
E
V
N
M
H
P
---------
A
K
L
E
K
P
L
Q
Q
A
I
A
A
T
H
T
G
Y
------------------------------
Y
T
--
V
D
G
M
T
Q
G
-
L
G
W
E
M
---
Y
P
Y
-
P
--
I
K
V
D
A
L
V
E
G
N
STQMAM
E
P
H
K
V
NWLTPPQA
A
----
P
L
D
T
L
V
------
N
K
T
G
-----
S
T
GG
F
G
---
A
Y
V
A
Y
V
P
S
K
G
L
G
V
V
I
L
A
N
K
N
Y
P
N
A
-----
E
R
V
K
A
A
H
A
I
L
S
A
M
-----------
42
Fugue
52.72
18%
1
- C3 -
-
1CI9
1
ESTB_BURGA
A:
[15-391]
--------------------------------------------------
A
A
S
L
A
A
R
L
D
A
V
F
D
Q
A
L
R
E
-
R
R
L
V
-
G
A
V
A
I
V
A
R
-
H
G
E
I
L
Y
R
R
A
Q
G
L
--
A
DR
E
A
-------
G
R
P
M
R
E
D
T
L
F
R
L
A
S
V
T
K
P
I
V
A
L
A
V
L
R
L
V
A
R
G
E
L
A
L
D
A
P
V
T
R
W
L
P
E
F
R
P
R
L
A
D
G
------------------
S
E
P
L
V
T
I
H
H
L
L
T
H
T
S
G
-
L
G
Y
W
L
L
E
G
A
G
S
---------
V
----------
Y
D
-----
R
L
GISDGIDLRDF
D
L
-
D
E
N
-
L
------------
R
R
L
A
S
A
--
P
L
S
F
A
P
G
S
G
W
Q
Y
S
--
L
A
L
D
-
V
L
G
A
V
V
E
R
A
T
G
Q
P
L
A
A
A
V
D
A
L
V
A
Q
P
L
G
M
R
D
C
--
G
F
V
S
A
---
E
P
--
E
R
-
F
-
A
V
P
Y
H
D
G
Q
P
--
E
-
P
V
R
M
R
D
G
I
E
V
P
L
P
E
G
-
H
G
A
A
V
R
F
A
P
S
R
V
F
E
P
G
A
Y
P
S
G
----------------------
G
A
G
M
Y
G
S
A
D
D
V
L
R
A
L
--
E
A
I
R
A
--------
N
P
G
F
L
P
E
T
L
A
D
A
A
R
R
D
Q
A
G
V
G
A
--------
E
-------------------
T
R
--
G
P
G
W
G
F
G
-
Y
L
S
A
V
---
L
D
D
-
P
--
A
----------------------------
A
AGTP
Q
H
A
G
T
L
------
Q
W
G
G
-----
V
Y
---
G
---
H
S
W
F
V
D
R
A
L
G
L
S
V
L
L
L
T
N
T
A
Y
E
G
M
S
-
G
---------
P
L
T
I
A
L
R
D
A
V
Y
A
-----
39
HHSearch
51.47
19%
-3
- C3 -
-
2DRW
-
?
B:
[7-360]
--------------------------------------------------------
A
I
Q
G
I
L
D
D
H
V
A
R
---
G
V
V
G
V
S
L
A
L
C
L
-
P
G
E
E
T
S
L
Y
Q
S
G
Y
--
A
--
D
K
FN-----
K
M
P
M
T
G
D
H
L
F
R
I
A
S
C
T
K
S
F
I
A
T
G
L
H
L
L
V
Q
D
G
T
V
D
L
D
E
P
I
T
R
W
F
P
D
L
P
----
K
--------------------
A
A
Q
M
P
V
R
I
L
L
N
H
R
S
G
-
L
-
P
D
F
E
-
T
S
M
P
---------
M
IS--------
D
K
-----
S
W
-----------
T
A
-
Q
E
I
-
V
------------
D
F
S
F
R
H
--
G
V
Q
K
E
P
W
H
G
M
E
Y
S
N
T
G
Y
-
V
-
L
A
G
M
I
I
A
H
E
T
G
K
P
Y
S
D
H
L
R
S
R
I
F
A
P
L
G
M
K
D
T
--
W
V
G
T
H
E
T
F
P
I
--
E
R
-
E
-
A
R
G
Y
M
H
--
A
A
A
D
-
D
E
----
N
P
---
Q
W
D
V
S
G
A
G
D
P
V
D
----------------
G
V
W
D
----
S
T
E
W
F
P
L
S
G
A
N
A
A
G
D
M
V
S
T
P
R
D
I
V
K
F
L
--
N
A
L
F
D
G
---------
R
I
L
D
Q
K
R
L
W
E
M
K
D
N
I
K
P
A
F
F
----------------------------
P
G
--
S
N
T
V
A
N
G
-
H
G
L
L
L
---
M
R
Y
--------------------------------------
G
S
S
E
L
K
------
G
H
L
G
-----
Q
I
P
--
G
H
T
-
S
I
M
G
R
D
E
E
T
G
A
A
L
M
L
I
Q
N
S
G
A
G
D
F
E
--
S
F
Y
L
K
G
V
N
E
P
V
D
R
V
L
E
A
I
K
N
------
34
HHSearch
50.43
17%
-21
- C3 -
-
4WZ4
2
AMPC_PSEAE
A:
[5-346]
----------------------------------------------------
R
L
K
A
L
V
D
A
A
V
Q
P
V
M
K
A
N
D
--
I
P
G
L
A
V
A
I
S
L
-
K
G
E
P
H
Y
-
F
S
Y
G
L
--
A
--
S
K
ED-----
G
R
R
V
T
P
E
T
L
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
T
Q
D
K
M
R
L
D
D
R
A
S
Q
H
W
P
A
L
Q
----
G
S
------------------
R
F
D
G
I
S
L
L
D
L
A
T
Y
T
A
G
-
G
-
L
P
L
Q
-
F
P
D
S
---------------------
V
-----
Q
K
-----------
D
Q
-
A
Q
I
-
R
------------
D
Y
Y
R
Q
W
--
Q
P
T
Y
A
P
G
S
Q
R
L
Y
S
N
P
S
I
-
G
-
L
F
G
Y
L
A
A
R
S
L
G
Q
P
F
E
R
L
M
E
Q
Q
V
F
P
A
L
G
L
E
Q
T
--
H
L
D
V
P
E
A
-
A
L
--
A
Q
-
Y
-
A
Q
G
Y
G
K
--
D
D
R
------------------------------------------
P
L
R
-----
V
G
--
P
G
P
L
D
A
E
G
Y
G
V
K
T
S
A
A
D
L
L
R
F
V
--
D
A
N
L
H
P
---------
E
R
L
D
R
P
W
A
Q
A
L
D
A
T
H
R
G
Y
Y
------------------------------
K
--
V
G
D
M
T
Q
G
-
L
G
W
E
A
---
Y
D
W
-
P
--
I
S
L
K
R
L
Q
A
G
N
S
T
P
M
A
L
Q
P
H
R
I
ARLPAPQA
L
----
E
G
Q
R
L
L
------
N
K
T
G
-----
S
T
NG
F
G
---
A
Y
V
A
F
V
P
G
R
D
L
G
L
V
I
L
A
N
R
N
Y
P
N
A
-----------------------------
32
HHSearch
49.79
17%
-23
- C3 -
-
4HEF
3
AMPC_PSEAE
A:
[4-346]
---------------------------------------------------
D
R
L
K
A
L
V
D
A
A
V
Q
P
V
M
K
A
N
D
--
I
P
G
L
A
V
A
I
S
L
-
K
G
E
P
H
Y
-
F
S
Y
G
L
--
A
--
S
K
ED-----
G
R
R
V
T
P
E
T
L
F
E
I
G
S
V
S
K
T
F
T
A
T
L
A
G
Y
A
L
T
Q
D
K
M
R
L
D
D
R
A
S
Q
H
W
P
A
L
Q
----
G
S
------------------
R
F
D
G
I
S
L
L
D
L
A
T
Y
T
A
G
-
G
-
L
P
L
Q
-
F
P
D
S
---------------------
V
-----
Q
K
-----------
D
Q
-
A
Q
I
-
R
------------
D
Y
Y
R
Q
W
--
Q
P
T
Y
A
P
G
S
Q
R
L
Y
S
N
P
S
I
-
G
-
L
F
G
Y
L
A
A
R
S
L
G
Q
P
F
E
R
L
M
E
Q
Q
V
F
P
A
L
G
L
E
Q
T
--
H
L
D
V
P
E
A
-
A
L
--
A
Q
-
Y
-
A
Q
G
Y
G
K
--
R
D
R
------------------------------------------
P
L
-------
R
V
G
P
G
P
L
D
A
E
G
Y
G
V
K
T
S
A
A
D
L
L
R
F
V
--
D
A
N
L
H
P
---------
E
R
L
D
R
P
W
A
Q
A
L
D
A
T
H
R
G
Y
Y
------------------------------
K
--
V
G
D
M
T
Q
G
-
L
G
W
E
A
---
Y
D
W
-
P
--
I
S
L
K
R
L
Q
A
G
N
S
T
P
M
A
L
Q
P
H
R
I
ARLPAPQA
L
----
E
G
Q
R
L
L
------
N
K
T
G
-----
S
T
NG
F
G
---
A
Y
V
A
F
V
P
G
R
D
L
G
L
V
I
L
A
N
R
N
Y
P
N
A
-----------------------------
22
HHSearch
49.49
18%
7
- C3 -
-
2QMI
-
?
F:
[3-333]
------------------------------------------------------
V
G
K
L
E
S
F
I
V
E
K
M
A
E
R
K
--
V
P
G
I
S
I
S
I
I
K
-
D
G
D
V
V
Y
A
K
G
F
G
Y
--
R
--
N
V
EA-----
R
L
P
S
T
P
E
T
I
Y
G
I
G
S
I
T
K
S
F
T
A
L
A
I
M
K
L
V
E
E
G
G
L
S
L
D
D
P
V
E
K
F
V
N
I
K
L
----
R
P
------------------
F
G
E
P
V
T
V
H
H
L
L
T
H
S
S
G
-
I
-
P
S
L
G
Y
A
E
A
F
IDGMVGGDN
W
----------
L
P
-----
V
S
-----------
T
P
-
E
E
T
-
I
------------
A
F
A
R
D
M
EK
W
A
V
A
K
P
G
E
R
F
F
Y
L
N
T
G
Y
-
V
-
L
L
G
K
I
I
E
K
V
S
G
V
S
Y
E
E
Y
I
K
K
K
I
L
E
P
L
G
M
N
R
S
--
Y
F
F
K
E
E
V
E
K
D
--
K
D
-
V
-
A
M
G
Y
I
L
--
D
K
E
-----------------------------------------
G
R
L
V
-----
P
Q
-
P
F
P
Y
G
I
T
A
D
G
G
L
L
S
S
V
L
D
L
A
K
Y
L
--
K
M
Y
I
E
R
D
--
E
-----
S
I
V
S
K
E
Y
I
E
K
M
E
T
S
Y
I
K
V
P
W
--------
E
--------------------
I
--
F
G
G
E
G
Y
G
-
Y
G
L
I
I
---
Y
P
N
---------------------------------
F
----
L
G
E
K
L
V
------
G
H
S
G
-----
S
V
---
G
MYT
G
Y
I
G
Y
I
P
E
K
K
I
G
V
A
V
L
E
N
S
S
G
Y
P
------------------------------
31
HHSearch
49.25
18%
-5
- C3 -
-
4NET
1
?
B:
[6-346]
-------------------------------------------------
K
D
Q
E
I
K
K
L
V
D
Q
N
F
K
P
L
L
E
K
Y
D
--
V
P
G
M
A
V
G
V
I
Q
-
N
N
K
-
K
Y
E
M
Y
Y
G
L
--
Q
--
S
V
QD-----
K
K
A
V
N
S
S
T
I
F
E
L
G
S
V
S
K
L
F
T
A
T
A
G
G
Y
A
K
N
K
G
K
I
S
F
D
D
T
P
G
K
Y
W
K
E
L
K
----
N
T
------------------
P
I
D
Q
V
N
L
L
Q
L
A
T
Y
T
S
G
-
N
-
L
A
L
Q
-
F
P
----------------------
D
E
-----
V
K
-----------
T
D
-
Q
Q
V
-
L
------------
T
F
F
K
D
W
--
K
P
K
N
S
I
G
E
Y
R
Q
Y
S
N
P
S
I
-
G
-
L
F
G
K
V
V
A
L
S
M
N
K
P
F
D
Q
V
L
E
K
T
I
F
P
A
L
G
L
K
H
S
--
Y
V
N
V
P
K
T
-
Q
M
--
Q
N
-
Y
-
A
-----------------------------------------------------------------
G
P
L
G
A
P
A
Y
G
V
K
S
T
L
P
D
M
L
S
F
I
--
H
A
N
L
N
P
---------
Q
K
Y
P
A
D
I
Q
R
A
I
N
E
T
H
Q
G
R
Y
------------------------------
Q
--
V
N
T
M
Y
Q
A
-
L
G
W
E
E
---
F
S
Y
-
P
--
A
T
L
Q
T
L
L
D
S
N
SEQIVM
K
P
N
K
V
T
A
I
SK---
E
----
P
S
V
K
M
Y
------
H
K
T
G
-----
S
T
NR
F
G
---
T
Y
V
V
F
I
P
K
E
N
I
G
L
V
M
L
T
N
K
R
I
P
N
E
-----------------------------
41
HHSearch
46.92
15%
-9
- C3 -
-
3HLF
1
LOVD_ASPTE
A:
[21-430]
------------------------------------------
G
S
I
I
D
A
A
A
A
A
G
P
V
V
L
M
E
T
A
F
R
K
A
V
E
S
R
Q
--
I
P
G
A
V
I
M
A
R
D
A
S
G
N
L
N
Y
T
R
C
F
G
A
--
R
--
T
V
RRDENN
Q
L
P
P
L
Q
V
D
T
P
C
R
L
A
A
A
T
K
L
L
T
T
I
M
V
L
Q
C
M
E
R
G
L
V
D
L
D
E
T
V
D
R
L
L
P
D
L
S
----
A
M
P
V
L
EGFDDAG
N
A
R
L
R
E
--
R
R
G
K
I
T
L
R
H
L
L
T
H
T
S
G
-
L
-
S
Y
V
F
-
L
H
P
L
---------
L
----------
R
E
Y
M
A
Q
G
Y
L
-----------
Q
S
A
E
K
F
G
I
------------
Q
S
R
L
A
P
--
P
A
V
N
D
P
G
A
E
W
I
Y
G
T
-
N
L
-
D
-
W
A
G
K
L
V
E
R
A
T
G
L
D
L
E
Q
Y
L
Q
E
N
I
C
A
P
L
G
I
T
D
M
--
T
F
K
L
Q
Q
R
-
P
D
M
L
A
R
-
R
A
D
Q
T
H
R
N
--
S
A
D
G
-
R
--------------------------------------
L
R
Y
-
D
D
S
V
Y
F
R
-
A
D
G
E
E
C
F
G
G
Q
G
V
F
S
S
P
G
S
Y
M
K
V
L
--
H
S
L
L
K
R
D
--
G
-----
L
L
L
Q
P
Q
T
V
D
L
M
F
Q
P
A
L
E
P
R
L
--------
E
E
Q
M
N
Q
H
M
D
A
S
PHINYGGPM
P
M
--
V
L
R
R
S
F
G
-
L
G
G
I
I
---
A
L
E
-
D
--
L
---------------------------------
D
G
E
N
W
R
------
R
K
G
S
L
T
F
G
G
G
P
---
N
---
I
V
W
Q
I
D
P
K
A
G
L
C
T
L
A
F
F
Q
L
E
P
W
N
D
P
V
C
R
D
L
T
R
T
F
E
H
A
I
Y
A
Q
Y
Q
----------
36
HHSearch
44.77
18%
-2
- C3 -
-
4U0X
1
?
B:
[7-345]
---------------------------------------------------
Q
E
I
K
K
L
V
D
Q
N
F
K
P
L
L
E
K
Y
D
--
V
P
G
M
A
V
G
V
I
Q
-
N
N
K
-
K
Y
E
M
Y
Y
G
L
--
Q
--
S
V
QD-----
K
K
A
V
N
S
N
T
I
F
E
L
G
S
V
S
K
L
F
T
A
T
A
G
G
Y
A
K
N
K
G
K
I
S
F
D
D
T
P
G
K
Y
W
K
E
L
K
----
N
T
------------------
P
I
D
Q
V
N
L
L
Q
L
A
T
Y
T
S
G
-
N
-
L
A
L
Q
-
F
P
----------------------
D
E
-----
V
Q
-----------
T
D
-
Q
Q
V
-
L
------------
T
F
F
K
D
W
--
K
P
K
N
P
I
G
E
Y
R
Q
Y
S
N
P
S
I
-
G
-
L
F
G
K
V
V
A
L
S
M
N
K
P
F
D
Q
V
L
E
K
T
I
F
P
A
L
G
L
K
H
S
--
Y
V
N
V
P
K
T
-
Q
M
--
Q
N
-
Y
-
A
F
G
Y
N
Q
--
E
N
Q
------------------------------------------
P
I
-------
R
V
N
P
G
P
L
D
A
P
A
Y
G
V
K
S
T
L
P
D
M
L
S
F
I
--
H
A
N
L
N
P
---------
Q
K
Y
P
T
D
I
Q
R
A
I
N
E
T
H
Q
G
R
Y
------------------------------
Q
--
V
N
T
M
Y
Q
A
-
L
G
W
E
E
---
F
S
Y
-
P
--
A
T
L
Q
T
L
L
D
S
N
SEQIVM
K
P
N
K
V
T
A
ISK---
E
----
P
S
V
K
M
Y
------
H
K
T
G
-----
S
T
SG
F
G
---
T
Y
V
V
F
I
P
K
E
N
I
G
L
V
M
L
T
N
K
R
I
P
N
E
-----------------------------
29
HHSearch
43.74
17%
-1
- C3 -
-
3O3V
-
?
B:
[42-370]
--------------------------------------------------------
R
L
S
T
L
I
H
Q
R
M
Q
E
A
K
--
V
P
A
L
S
V
S
V
T
I
-
K
G
V
-
R
Q
R
F
V
Y
G
V
--
A
--
D
V
AS-----
Q
K
A
N
T
L
D
T
V
Y
E
L
G
S
M
S
K
A
F
T
G
L
V
V
Q
I
L
I
Q
E
G
R
L
R
Q
G
D
D
I
I
T
Y
L
P
E
M
R
----
L
N
YQG---------------
K
P
A
S
L
T
V
A
D
F
L
Y
H
T
S
G
-
L
-
P
F
S
T
-
L
A
R
----------
L
----------
E
N
-----
P
M
-----------
P
G
-
S
A
V
-
A
------------
Q
Q
L
R
N
E
--
N
L
L
F
A
P
G
A
K
F
S
Y
A
S
A
N
Y
-
D
-
V
L
G
A
V
I
E
N
V
T
G
K
T
F
T
E
V
I
A
E
R
L
T
Q
P
L
G
M
S
A
T
--
V
A
V
K
G
D
E
-
I
I
--
V
N
-
K
-
A
S
G
Y
K
L
--
G
F
G
-----------------------------------------
K
P
V
----
L
-
F
H
A
P
L
A
R
N
H
V
P
A
A
Y
I
H
S
T
L
P
D
M
E
I
W
I
--
D
A
W
L
H
R
---------
K
A
L
P
A
T
L
R
E
A
M
S
N
S
W
R
G
N
S
D
VP------
L
-------------------
A
A
--
D
N
R
I
L
Y
A
-
S
G
W
F
I
---
D
Q
N
---------------------------------------
Q
G
P
Y
I
------
S
H
G
G
-----
Q
N
P--
N
FS-
S
C
I
A
L
R
P
D
Q
Q
I
G
I
V
A
L
A
N
M
N
S
N
L
I
-------
L
Q
L
C
A
D
I
D
N
Y
L
-----------
30
HHSearch
42.93
17%
-8
- C3 -
-
4E6W
1
?
A:
[2-330]
--------------------------------------------------------
R
L
S
T
L
I
H
Q
R
M
Q
E
A
K
--
V
P
A
L
S
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S
V
T
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V
-
R
Q
R
F
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Y
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V
--
A
--
D
V
AS-----
Q
K
A
N
T
L
D
T
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Y
E
L
G
S
M
S
K
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F
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V
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L
I
Q
E
G
R
L
R
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D
D
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I
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Y
L
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M
R
----
L
N
Y
QG---------------
K
P
A
S
L
T
V
A
D
F
L
Y
H
T
S
G
-
L
-
P
F
S
T
-
L
A
R
----------
L
----------
E
-----------------------
A
V
-
A
------------
Q
Q
L
R
N
E
--
N
L
L
F
A
P
G
A
K
F
S
Y
A
S
A
N
Y
-
D
-
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D
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N
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-
A
S
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L
--
G
F
G
-----------------------------------------
K
P
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----
L
-
F
H
A
P
L
A
R
N
H
V
P
A
A
Y
I
H
S
T
L
P
D
M
E
I
W
I
--
D
A
W
L
H
R
---------
K
A
L
P
A
T
L
R
E
A
M
S
N
S
W
R
G
N
S
D
V
P
------
L
-------------------
A
A
--
D
N
R
I
L
Y
A
-
S
G
W
F
I
---
D
Q
N
---------------------------------------
Q
G
P
Y
I
------
S
H
G
G
-----
Q
N
P--
N
F
S
-
S
C
I
A
L
R
P
D
Q
Q
I
G
I
V
A
L
A
N
M
N
S
N
L
I
-------
L
Q
L
C
A
D
I
D
N
Y
L
-----------