@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRP5: (2017-12-04 )
MRVMMSSLKILITKLSTAARTALEKSANACVLQQNYEIEIEHLFLELLNQPLENDLKILLKKYKISADALADDLKETISQLPKGNTRTPIFAKSIVRLFEQAWLLASAEQNPVIRSGHLLVALLTAPDLYQIATRASSLFDLFPIDSMKHKFLEICEKSVEQQEESKTSSQADELEQAVTPTAKTQKTPALDQYTINLTEKAKNGGIDPVIGREYEIRLMLDILMRRRQNNPILTGEPGVGKTAVVEGLALKIAQGLVPEALKNVHLHVLDMGLLQAGASVKGEFENRLKQVIQEVQSSAHPIILFIDEAHTLIGAGGQAGQNDAANLLKPALARGELRTIAATTWAEYKQYFEKDAALSRRFQVVKVEEPTEEVAVDMLRAMIPVMQKHFNLQIDDEAIVTAVHASHRYISGRQLPDKAVSVLDTAAARVALTQNAQPVKLDQLKAQEHNLKLEQQILENEHLQIPIHHERLENLKNQLKSLQSEIQETQEQWQKELELVRKIQELEAQSHSNESEAYDQINLIRKDLADIQGQQPLVFERVNSQIINEIISDWTGIPVGKMVNDEIKQILTLEDKLGERVMGQDYALTQLVQGIKTSKAKLEDPNKPQGVFLLVGPSGVGKTETALALANELYGGEQHLITINMSEYQEAHTVSSLKGAPPGYVGYGQGGVLTEAVRRNPYSVVLLDEIEKAHSDVQELFYQVFDKGTLEDGEGRVIDFKNTTILLTSNTGSSAIMQACLNQPVEEWPTAEDLIEHLKPILYKQFKPAFLGRMRVVPYFPLHDDLLVRIIKHKLGKITARIEKQYGTKVQYSDDLVELLLSRCTEVDSGARNVDNILNSTVLPALATEILVALADQKLPKLIMIDAKDDEIQYLLDPVAKPAKKRTSKKLKSEV
Atome Classification :
(21 SA)
.........10........20........30........40........50........60........70........80........--90........100.......110.......120.......130.......140-........150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.....-------..500.......510.....---------..520--------------.........530.----------....---..540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740....-----.--..750.......760.......770...-.-...780.......790.......800..---.....810.......820.......830.......840.......850.......860.......870.......880.......890....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MR
V
M
M
S
S
L
K
I
L
I
T
K
L
S
T
A
A
R
T
A
L
E
KSAN
A
C
V
L
QQN
Y
E
I
E
I
E
H
L
F
L
E
L
L
NQ
P
L
E
N
D
L
K
I
L
L
K
K
YKI
S
A
D
A
L
A
D
D
L
K
E
T
I
S
QLPKGNTRT
P
--
I
F
A
K
S
I
V
R
L
F
E
Q
A
W
L
LASAEQN
P
V
IRSG
H
L
L
V
A
L
LTAP
D
L
Y
Q
I
A
T
R
A
S
S
L
FD--LFP
I
D
S
M
K
H
K
F
L
E
I
C
E
K
S
V
E
Q
Q
E
ESKTS
S
Q
A
D
E
L
E
Q
AVTPTAKTQKTPAL
D
Q
Y
T
I
NLTEKAKNGGIDPVIGRE
Y
E
I
R
L
M
L
D
I
L
M
R
RRQNN
P
I
LTGEPGV
G
K
T
A
V
V
E
G
L
A
L
K
I
A
Q
G
L
V
P
E
A
L
K
N
V
H
L
H
V
L
D
M
G
L
L
QAGASV
K
G
E
F
E
N
R
L
K
Q
V
I
Q
E
V
Q
SSAH
P
I
I
L
F
IDEA
H
T
LIGAGGQAGQN
D
A
A
N
L
L
K
P
A
LARG
E
L
R
T
I
A
A
T
T
W
A
E
Y
K
Q
Y
F
E
K
D
A
A
L
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VEE
P
T
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E
V
A
V
D
M
L
R
A
M
I
P
V
M
Q
K
HF
N
L
Q
IDD
E
A
I
V
T
AVHASHRYISGRQL
P
D
K
A
V
S
V
L
D
T
A
A
A
R
V
A
LTQNAQPV
K
L
D
Q
L
K
A
Q
E
HN
L
K
L
E
Q
Q
I
LENE
H
L
Q
I
P
I
H
H
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R
L
E
N
L
K
N
Q
L
K
S
L
Q
S
E
I
Q
E
T
Q
E
Q
W
Q
K
E
-------
L
E
L
V
R
K
I
Q
E
L
E
A
QSHSN
E
S
E
---------
A
Y
D
----------------
Q
I
N
L
I
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K
D
L
A
D
IQ----------GQQP---
L
V
F
E
R
V
N
S
Q
I
I
N
E
I
I
S
DWTGIP
V
G
K
M
V
N
D
E
I
K
Q
I
L
T
L
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D
K
L
G
E
R
VMGQ
D
Y
A
L
T
Q
L
V
Q
G
I
K
TSKAKLEDPNKP
Q
G
V
F
L
L
VGPSGVGK
T
E
T
A
L
A
L
A
N
E
LYGGE
Q
H
L
I
T
I
N
M
S
E
Y
Q
E
A
H
T
V
S
SLKGAPPGYVGYGQG
G
V
L
T
E
A
V
RRNP
Y
S
V
V
L
L
D
E
I
E
K
A
H
S
D
V
Q
E
L
F
Y
Q
V
F
DKGTLEDGE
G
R
V
I
D
FKN
T
T
I
L
L
TSNT
G
S
S
A
I
M
Q
A
C
LNQ
P
V
-----
E
--EWP
T
A
E
D
L
I
E
H
L
K
P
I
L
Y
K
QF
K
P
A
F
LGR
M
-
R
-
V
V
P
YFPL
H
D
D
L
L
V
R
I
I
K
H
K
L
G
K
I
T
A
R
I
E
---
K
Q
YG
T
K
V
QY
S
D
D
L
V
E
L
L
L
S
R
C
T
EVDSGA
R
N
V
D
N
I
L
N
S
T
V
L
P
A
L
A
T
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I
L
V
A
L
A
DQKL
P
K
L
I
M
I
DAKDD
E
I
Q
Y
L
L
DPVAK
P
A
K
K
R
T
S
K
K
L
KSEV
94
Fugue
100.00
37%
0
- C- -
-
1QVR
-
CLPB_THET8
A:
[4-850]
------------
E
R
W
T
Q
A
A
R
E
A
L
A
Q
A
Q
V
L
A
Q
R
M
K
H
Q
A
I
D
L
P
H
L
W
A
V
L
L
K
D
E
-
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L
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Y
L
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L
V
L
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L
A
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A
--------------------------------
T
P
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A
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R
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H
A
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Y
N
A
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Y
G
I
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L
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L
A
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P
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L
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P
G
V
G
K
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A
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G
L
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R
I
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K
G
D
V
P
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G
L
K
G
K
R
I
V
S
L
Q
M
-----------
E
F
E
E
R
L
K
A
V
I
Q
E
V
V
Q
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Q
G
E
V
I
L
F
I
D
E
-------------------
L
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P
A
L
A
R
G
E
L
R
L
I
G
A
T
T
L
D
E
Y
R
E
I
-
E
K
D
P
A
L
E
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R
F
Q
P
V
Y
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P
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V
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I
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I
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L
K
E
K
Y
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H
H
G
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S
A
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A
A
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K
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--
K
D
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D
S
Q
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K
A
I
E
A
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A
K
L
T
E
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I
A
K
L
R
A
E
W
E
R
E
-------
R
E
I
L
R
K
L
R
E
A
Q
H
R
L
D
E
V
R
R
E
---------
I
E
L
A
E
R
Q
YDLN
R
A
A
E
L
R
Y
G
E
L
P
K
L
E
A
E
V
E
A
L
S
----------
E
K
L
R
GAR
F
V
R
L
E
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
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S
K
L
L
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R
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K
L
L
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L
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E
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L
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K
R
V
V
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D
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A
I
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A
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A
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A
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A
R
A
G
L
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D
P
N
R
P
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S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
R
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
Q
--------------
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
W
------------
P
Y
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
-
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
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Q
L
S
Y
L
R
A
R
L
A
---
E
K
-
R
I
S
L
E
L
T
E
A
A
K
D
F
L
A
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G
Y
D
P
V
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A
R
P
L
R
R
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I
Q
R
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L
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T
P
L
A
Q
K
I
L
A
G
E
V
K
E
G
--
D
R
V
Q
V
D
V
G
P
A
G
L
V
F
A
V
P
A
-----------------
8
PsiBlast_PDB
72.53
33%
-15
- C3 -
-
5VY9
3
?
A:
[87-859]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
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D
H
I
L
F
A
L
F
N
D
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S
I
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Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
-----------
R
G
---------------------
Y
L
S
K
Y
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M
T
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K
T
L
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L
F
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D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
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K
P
A
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N
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N
K
A
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R
YD
T
A
T
A
A
D
L
R
Y
F
----------------
A
I
P
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K
K
Q
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V
AEEERRA
G
A
N
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---
M
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V
V
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A
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A
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L
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C
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G
A
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I
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---
Q
Q
G
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-----
K
--
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Q
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K
N
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---
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K
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K
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R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
29
PsiBlast_CBE
72.08
33%
-86
- C3 -
-
5VY9
4
?
C:
[87-859]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
I
Q
Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
-----------
R
G
---------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
30
PsiBlast_CBE
72.07
33%
-13
- C3 -
-
5VY9
4
?
B:
[87-859]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
I
Q
Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
-----------
R
G
---------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
K
H
GHEEL
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
Y
D
T
A
T
A
A
DL
R
Y
F
----------------
A
I
P
D
I
K
K
Q
I
E
K
L
E
DQVAEEE
R
R
A
G
A
N
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
26
PsiBlast_CBE
71.72
33%
-11
- C3 -
-
5VY9
3
?
F:
[87-859]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
I
Q
Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
-----------
R
G
---------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
KHGHEEL
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
YDTATAADL
R
Y
F
----------------
A
I
P
D
I
K
K
Q
I
E
K
L
E
DQVAEEERRA
G
A
N
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
28
PsiBlast_CBE
71.59
33%
-93
- C3 -
-
5VY9
4
?
D:
[87-859]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
I
Q
Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
-----------
R
G
---------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
27
PsiBlast_CBE
71.44
33%
-15
- C3 -
-
5VY9
4
?
E:
[87-859]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
I
Q
Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
-----------
R
G
---------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
KHGHEEL
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
YDTATAADL
R
Y
F
----------------
A
I
P
D
I
K
K
Q
I
E
K
L
E
DQVAEEERRA
G
A
N
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
31
PsiBlast_CBE
69.34
33%
-99
- C3 -
-
5VY8
2
?
F:
[166-857]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
42
PsiBlast_CBE
69.27
32%
-64
- C3 -
-
5KNE
2
HS104_YEAST
D:
[82-840]
---------------------------------------------------------------------------------------
T
P
--
S
Y
A
--
L
G
K
V
L
Q
D
A
A
K
I
Q
K
Q
Q
K
D
S
F
I
A
Q
D
H
I
L
F
A
L
F
N
D
S
S
I
Q
Q
I
F
K
E
A
Q
-------
V
D
I
E
A
I
K
Q
Q
A
L
E
L
R
G
N
T
---
R
I
D
S
R
G
A
D
T
N
T
P
L
E
Y
-------------
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
-------
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
----
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
-----------------------------------------------------------------------------------
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
----
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
4
PsiBlast_PDB
69.27
37%
-36
- C3 -
-
3J3U
-
CLPC_BACSU
A:
[144-782]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
-----
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
-------------------
E
K
Q
G
Q
E
N
S
E
V
---------
T
V
D
----------------
D
I
A
M
---------------------------------------
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
---
N
K
Y
V
GFNVQ
D
--
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
-
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
---
E
Q
-
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
--------------------------------------------
1
PsiBlast_PDB
69.09
38%
-38
- C3 -
-
3J3S
-
CLPC_BACSU
A:
[144-782]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
G
N
-
I
I
L
F
I
D
E
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
-----
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
-------------------
E
K
Q
G
Q
E
N
S
E
V
---------
T
V
D
----------------
D
I
A
M
---------------------------------------
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
---
N
K
Y
V
GFNVQ
D
--
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
-
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
---
E
Q
-
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
--------------------------------------------
106
HHSearch
68.88
33%
-
* C4 *
-
3PXI
-
CLPC_BACSU
A:
[3-807]
-----------
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
-
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
-
M
S
Q
T
I
--
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
-----
A
R
V
L
N
NL
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
E
T
G
S
-------------------
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
---------------
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
I
I
L
F
I
D
A
--------------------
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
--
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
-----------------------------
S
Q
E
F
E
K
A
-------
A
----
S
L
R
D
T
E
Q
R
L
R
----------------
E
----------------
Q
V
E
D
T
K
K
S
W
K
-------------
E
K
Q
G
---
Q
---
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
-----------------
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
-----
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
K
D
K
--------------------------
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
-
D
E
I
I
V
F
H
--
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
---
E
-
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
--
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
T
A
-----------------
35
PsiBlast_CBE
68.73
33%
-88
- C3 -
-
5VY8
2
?
B:
[166-857]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
105
HHSearch
68.67
34%
31
- C4 -
-
3J3U
-
CLPC_BACSU
B:
[3-807]
-----------
F
G
R
F
T
E
R
A
Q
K
V
L
A
L
A
Q
E
E
A
L
R
L
G
H
N
N
I
G
T
E
H
I
L
L
G
L
V
R
E
G
-
E
G
I
A
A
K
A
L
Q
A
L
G
L
G
S
E
K
I
Q
K
E
V
E
S
L
I
G
R
G
Q
E
-
M
S
Q
T
I
--
H
Y
T
P
R
A
K
K
V
I
E
L
S
M
D
E
A
R
K
L
G
H
S
Y
V
G
T
E
H
I
L
L
G
L
I
R
E
G
E
G
V
A
-----
A
R
V
L
N
N
L
G
V
S
L
N
K
A
R
Q
Q
V
L
Q
L
L
G
S
N
E
T
G
S
--------------
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
-
A
G
N
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
K
L
D
E
V
R
K
E
K
-------
D
A
A
V
----------------
Q
S
Q
E
F
E
K
A
A
S
L
R
D
T
-------
E
Q
R
L
R
E
Q
V
------------------------------------------
E
D
T
K
K
S
W
---
K
----------
E
K
Q
G
---
Q
E
N
S
E
V
T
V
D
D
I
A
M
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
N
K
Y
V
G
F
N
-----
V
Q
D
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
-
D
E
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
---
E
-
Q
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
R
G
N
I
H
K
G
--
Q
H
I
V
L
D
V
E
D
G
E
F
V
V
K
T
T
A
-----------------
33
PsiBlast_CBE
68.19
33%
-6
- C3 -
-
5VY8
3
?
D:
[166-857]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
KHGHEEL
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
YDTATAADL
R
Y
F
----------------
A
I
P
D
I
K
K
Q
I
E
K
L
E
DQVAEEERRA
G
A
N
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
2
PsiBlast_PDB
68.14
38%
-34
- C3 -
-
3J3T
-
CLPC_BACSU
A:
[144-782]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
-----
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
-------------------
E
K
Q
G
Q
E
N
S
E
V
---------
T
V
D
----------------
D
I
A
M
---------------------------------------
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
---
N
K
Y
V
GFNVQ
D
--
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
-
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
---
E
Q
-
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
--------------------------------------------
3
PsiBlast_PDB
68.04
37%
-37
- C3 -
-
3J3R
-
CLPC_BACSU
A:
[144-782]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
E
T
G
S
S
A
A
G
T
N
S
N
A
N
T
P
T
L
D
S
L
A
R
D
L
T
A
I
A
K
E
D
S
L
D
P
V
I
G
R
S
K
E
I
Q
R
V
I
E
V
L
S
R
R
T
K
N
N
P
V
L
I
G
E
P
G
V
G
K
T
A
I
A
E
G
L
A
Q
Q
I
I
N
N
E
V
P
E
I
L
R
D
K
R
V
M
T
L
D
M
G
T
V
V
A
G
T
K
Y
R
G
E
F
E
D
R
L
K
K
V
M
D
E
I
R
Q
A
G
N
-
I
I
L
F
I
D
A
L
H
T
L
I
G
A
G
G
A
E
G
A
I
D
A
S
N
I
L
K
P
S
L
A
R
G
E
L
Q
C
I
G
A
T
T
L
D
E
Y
R
K
Y
I
E
K
D
A
A
L
E
R
R
F
Q
P
I
Q
V
D
Q
P
S
V
D
E
S
I
Q
I
L
Q
G
L
R
D
R
Y
E
A
H
H
R
V
S
I
T
D
D
A
I
E
A
A
V
K
L
S
D
R
Y
I
S
D
R
F
L
P
D
K
A
I
D
L
I
D
E
A
G
S
K
V
R
L
R
S
F
T
T
P
P
N
L
K
E
L
E
Q
-----
K
L
D
E
V
R
K
E
K
D
A
A
V
Q
S
Q
E
F
E
K
A
A
S
L
R
D
T
E
Q
R
L
R
E
Q
V
E
D
T
K
K
S
W
K
-------------------
E
K
Q
G
Q
E
N
S
E
V
---------
T
V
D
----------------
D
I
A
M
---------------------------------------
V
V
S
S
W
T
-------
A
Q
T
E
T
D
K
L
L
N
M
E
N
I
L
H
S
R
V
I
G
Q
D
E
A
V
V
A
V
A
K
A
V
R
R
A
R
A
G
L
K
D
P
K
R
P
I
G
S
F
I
F
L
G
P
T
G
V
G
K
T
E
L
A
R
A
L
A
E
S
I
F
G
D
E
E
S
M
I
R
I
D
M
S
E
Y
M
E
K
H
S
T
S
R
L
V
G
S
P
P
G
Y
V
G
Y
D
E
G
G
Q
L
T
E
K
V
R
R
K
P
Y
S
V
V
L
L
D
A
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
V
L
E
D
G
R
L
T
D
S
K
G
R
T
V
D
F
R
N
T
I
L
I
M
T
S
N
V
G
A
S
E
L
K
R
---
N
K
Y
V
GFNVQ
D
--
E
T
Q
N
H
K
D
M
K
D
K
V
M
G
E
L
K
R
A
F
R
P
E
F
I
N
R
I
D
E
-
I
I
V
F
H
S
L
E
K
K
H
L
T
E
I
V
S
L
M
S
D
Q
L
T
K
R
L
K
---
E
Q
-
D
L
S
I
E
L
T
D
A
A
K
A
K
V
A
E
E
G
V
D
L
E
Y
G
A
R
P
L
R
R
A
I
Q
K
H
V
E
D
R
L
S
E
E
L
L
--------------------------------------------
32
PsiBlast_CBE
68.02
33%
-11
- C3 -
-
5VY8
3
?
E:
[166-857]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
KHGHEEL
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
YDTATAADL
R
Y
F
----------------
A
I
P
D
I
K
K
Q
I
E
K
L
E
DQVAEEERRA
G
A
N
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
6
PsiBlast_PDB
67.97
33%
-86
- C3 -
-
5VY8
2
?
A:
[166-857]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
34
PsiBlast_CBE
67.53
33%
-11
- C3 -
-
5VY8
3
?
C:
[166-857]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
S
K
Y
A
I
D
M
T
E
Q
A
R
Q
G
K
L
D
P
V
I
G
R
E
E
E
I
R
S
T
I
R
V
L
A
R
R
I
K
S
N
P
C
L
I
G
E
P
G
I
G
K
T
A
I
I
E
G
V
A
Q
R
I
I
D
D
D
V
P
T
I
L
Q
G
A
K
L
F
S
L
D
L
A
A
L
T
A
G
A
K
Y
K
G
D
F
E
E
R
F
K
G
V
L
K
E
I
E
E
S
K
T
L
I
V
L
F
I
D
E
I
H
M
L
M
G
----
N
G
K
D
D
A
A
N
I
L
K
P
A
L
S
R
G
Q
L
K
V
I
G
A
T
T
N
N
E
Y
R
S
I
V
E
K
D
G
A
F
E
R
R
F
Q
K
I
E
V
A
E
P
S
V
R
Q
T
V
A
I
L
R
G
L
Q
P
K
Y
E
I
H
H
G
V
R
I
L
D
S
A
L
V
T
A
A
Q
L
A
K
R
Y
L
P
Y
R
R
L
P
D
S
A
L
D
L
V
D
I
S
C
A
G
V
A
V
A
R
D
S
K
P
E
E
L
D
S
K
E
R
Q
L
Q
L
I
Q
V
E
I
K
A
L
E
R
D
E
D
A
D
S
T
T
K
D
R
L
K
L
A
R
Q
K
E
A
S
L
Q
E
E
L
E
P
L
R
Q
R
Y
N
E
E
KHGHEEL
T
Q
A
K
K
K
L
D
E
L
E
N
K
A
L
D
A
E
R
R
YDTATAADL
R
Y
F
----------------
A
I
P
D
I
K
K
Q
I
E
K
L
E
DQVAEEERRA
G
A
N
S
---
M
I
Q
N
V
V
D
S
D
T
I
S
E
T
A
A
R
L
T
G
I
P
V
K
K
L
S
E
S
E
N
E
K
L
I
H
M
E
R
D
L
S
S
E
V
V
G
Q
M
D
A
I
K
A
V
S
N
A
V
R
L
S
R
S
G
L
A
N
P
R
Q
P
-
A
S
F
L
F
L
G
L
S
G
S
G
K
T
E
L
A
K
K
V
A
G
F
L
F
N
D
E
D
M
M
I
R
V
D
C
S
E
L
S
E
K
Y
A
V
S
K
L
L
G
T
T
A
G
Y
V
G
Y
D
E
G
G
F
L
T
N
Q
L
Q
Y
K
P
Y
S
V
L
L
F
D
E
V
E
K
A
H
P
D
V
L
T
V
M
L
Q
M
L
D
D
G
R
I
T
S
G
Q
G
K
T
I
D
C
S
N
C
I
V
I
M
T
S
N
L
G
A
E
F
I
N
S
---
Q
Q
G
S
-----
K
--
I
Q
E
S
T
K
N
L
V
---
M
G
A
V
R
Q
H
F
R
P
E
F
L
N
R
I
S
S
-
I
V
I
F
N
K
L
S
R
K
A
I
H
K
I
V
D
I
R
L
K
E
I
E
E
R
F
E
QND
K
H
Y
--
K
L
N
L
T
Q
E
A
K
D
F
L
A
K
Y
G
Y
S
D
D
M
G
A
R
P
L
N
R
L
I
Q
N
E
I
L
N
K
L
A
L
R
I
L
--------------------------------------------
16
PsiBlast_PDB
55.70
42%
-84
- C3 -
-
4LJA
2
A:
[6-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
E
E
D
I
A
E
I
V
S
R
W
T
G
I
P
V
S
K
L
L
E
G
E
----
L
R
L
E
E
E
L
H
K
R
V
V
G
Q
D
E
A
I
R
A
V
A
D
A
I
R
R
A
R
A
G
L
K
D
P
N
R
P
I
G
S
F
L
F
L
G
P
T
G
V
G
K
T
E
L
A
K
T
L
A
A
T
L
F
D
T
E
E
A
M
I
Q
I
D
M
T
E
Y
M
E
K
H
A
V
S
R
L
I
G
A
P
P
-------
G
G
Q
L
T
E
A
V
R
R
R
P
Y
S
V
I
L
F
D
E
I
E
K
A
H
P
D
V
F
N
I
L
L
Q
I
L
D
D
G
R
L
T
D
S
H
G
R
T
V
D
F
R
N
T
V
I
I
L
T
S
N
L
G
S
P
L
I
L
E
G
L
Q
K
G
-----------
W
P
Y
-
E
R
I
R
D
E
V
F
K
V
L
Q
Q
H
F
R
P
E
F
L
N
R
L
D
E
-
I
V
V
F
R
P
L
T
K
E
Q
I
R
Q
I
V
E
I
Q
L
S
Y
L
R
A
R
L
A
---
E
K
R
-
I
S
L
E
L
T
E
A
A
K
D
F
L
A
E
R
G
Y
D
P
V
F
G
A
R
P
L
R
R
V
I
Q
R
E
L
E
T
P
L
A
Q
K
I
L
A
G
------------------------------------------