@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRS5: (2017-12-04 )
MEGIKTIGVVGVGVIGASWTALFLYKGFKVKVYGPYPIDEELFKKRIQANLSDLLALDQQTDSSHHLQDIFLNLELYNNLKDAVIDADFIQENAPERLDLKQNLYQEITSYCPEKTLIASSSSGLKVSDFQKDATHPERIFLGHPFNPPHLLPLVEIVGGKLTDPQILKKASEFYQSLGKHPIVLNKEVKGHVANRLQAALWREAFSLVKEGVCSAEDVDIAITSGPGLRWALFGPYINMELANQKGFKEAIHHLGPPMTEWWNDMQNFQHSEETTELLEEQTKELLTHYKDIDLSQKRDKGLVDILKLKQQLELD
Atome Classification :
(20 SA)
.........10........20........30........40........50--......---...60..---......70.......---.80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.....-------..250.......260----....--..--.270.......280------.....--..290....------....---.300.......310....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEG
I
K
T
I
G
V
V
G
V
GVIGAS
W
T
A
L
F
L
YKG
F
K
V
K
V
YGPYPI
D
E
E
L
F
K
K
R
I
Q
A
N
---
L
S
D
L
L
A
---LDQQTDS---SH
H
L
Q
D
I
F
L
N
L
E
L
YN---N
L
K
D
AVI
D
A
D
F
I
QENAP
E
R
L
D
L
K
Q
N
L
Y
Q
E
I
T
S
YCPE
K
T
L
I
ASSSSG
L
K
VSDFQKDATHP
E
R
I
F
LGHPFN
P
P
H
L
L
P
L
V
E
I
VGGKLT
D
P
Q
I
L
K
K
A
S
E
F
Y
Q
S
LGKH
P
I
V
LN
K
E
V
K
G
H
V
A
N
R
L
Q
A
A
L
W
R
E
A
F
S
L
V
K
EGVCSAE
D
V
D
I
A
I
TSGPG
L
R
W
A
L
FG
P
Y
I
N
M
E
LANQK
G
-------
F
K
E
A
I
H
HLGP
P
M
T
E
W
----
W
N
D
M
--
Q
N
--FQ
H
S
E
E
T
T
E
L
L
E
E
Q
------
T
K
E
L
L
--
T
H
Y
--KDID------LSQK---RD
K
G
L
V
D
I
L
K
L
K
Q
Q
LELD
51
HHSearch
75.04
29%
-100
- C1 -
-
3F3S
5
CRYL1_HUMAN
A:
[2-312]
--
M
A
G
C
V
V
I
V
G
S
G
V
I
G
R
S
W
A
M
L
F
A
S
G
G
F
Q
V
K
L
Y
D
I
E
Q
Q
Q
I
R
N
A
L
E
N
I
R
K
E
---
M
K
L
L
E
Q
---
A
G
S
L
K
G
S
----
L
S
V
E
E
Q
L
S
L
I
S
G
C
P
---
N
I
Q
E
A
V
E
G
A
M
H
I
Q
E
C
V
P
E
D
L
E
L
K
K
K
I
F
A
Q
L
D
S
I
I
D
D
R
V
I
L
S
S
S
T
S
C
L
M
P
S
K
L
F
A
G
L
V
H
V
K
Q
C
I
V
A
H
P
V
N
P
P
Y
Y
I
P
L
V
E
L
V
P
H
P
E
T
A
P
T
T
V
D
R
T
H
A
L
M
K
K
I
G
Q
C
P
M
R
V
Q
K
E
V
A
G
F
V
L
N
R
L
Q
Y
A
I
I
S
E
A
W
R
L
V
E
E
G
I
V
S
P
S
D
L
D
L
V
M
S
E
G
L
G
M
R
Y
A
F
I
G
P
L
E
T
M
H
L
N
A
-
E
G
-------
M
L
S
Y
C
D
R
Y
S
E
G
I
K
H
V
----
L
Q
T
F
--
G
P
I-
P
E
F
S
R
A
T
A
E
K
V
N
Q
D
------
M
C
M
K
V
--
P
D
D
P
E
H
L
A
A
------
R
R
Q
W
---
R
D
E
C
L
M
R
L
A
K
L
K
S
Q
----
4
PsiBlast_PDB
72.96
30%
-22
- C1 -
-
3ADP
1
CRYL1_RABIT
A:
[11-316]
--------
I
V
G
S
G
L
V
G
R
S
W
A
M
L
F
A
S
G
G
F
R
V
K
L
Y
D
I
E
P
R
Q
I
T
G
A
L
E
N
I
R
K
E
---
M
K
S
L
-------
Q
Q
S
G
S
LKG
S
L
S
A
E
E
Q
L
S
L
I
S
S
C
T
---
N
L
A
E
A
V
E
G
V
V
H
I
Q
E
C
V
P
E
N
L
D
L
K
R
K
I
F
A
Q
L
D
S
I
V
D
D
R
V
V
L
S
S
S
S
S
C
L
L
P
S
K
L
F
T
G
L
A
H
V
K
Q
C
I
V
A
H
P
V
N
P
P
Y
Y
I
P
L
V
E
L
V
P
H
P
E
T
S
P
A
T
V
D
R
T
H
A
L
M
R
K
I
G
Q
S
P
V
R
V
L
K
E
I
D
G
F
V
L
N
R
L
Q
Y
A
I
I
S
E
A
W
R
L
V
E
E
G
I
V
S
P
S
D
L
D
L
V
M
S
D
G
L
G
M
R
Y
A
F
I
G
P
L
E
T
M
H
L
-
N
A
E
G
-------
M
L
S
Y
C
D
R
Y
S
E
G
M
K
R
V
-------
L
--
K
S
--
F
G
S
I
P
E
F
S
G
A
T
V
E
K
------
V
N
Q
A
M
--
C
K
K
--
V
P
A
D
P
E
H
---
L
A
A
R
R
E
W
R
D
E
C
L
K
R
L
A
K
L
K
R
Q
M
---
52
HHSearch
71.72
27%
-94
- C1 -
-
4OM8
3
?
B:
[1-308]
--
M
I
R
N
I
A
I
I
G
L
G
T
M
G
P
G
M
A
A
R
L
A
R
G
G
L
Q
V
V
A
Y
D
V
A
P
A
A
I
E
R
A
R
S
M
L
S
V
A
---
E
T
V
L
D
A
---
L
G
I
---
A
-----
L
P
S
A
G
V
G
T
V
R
F
T
D
---
D
I
G
D
A
V
S
G
A
D
L
V
I
E
N
V
P
E
N
I
S
I
K
A
D
V
Y
R
T
I
D
G
L
I
G
Q
D
T
I
V
A
S
D
T
S
G
I
P
I
T
K
L
Q
A
H
I
S
Y
P
E
R
M
V
G
M
H
W
S
N
P
P
H
I
I
P
M
I
E
V
I
A
G
E
K
T
A
P
Q
T
V
A
T
I
R
D
L
I
R
S
I
G
L
L
P
V
V
V
K
K
D
V
P
G
F
V
E
N
R
V
L
Y
A
L
L
R
E
A
V
D
L
V
E
R
G
V
I
D
P
E
D
L
D
T
C
V
S
W
G
I
G
Y
K
I
A
V
I
G
P
M
A
L
L
D
M
A
G
L
D
I
-------
Y
K
S
V
S
S
F
L
N
A
D
L
S
N
R
--------------
D
D
V
A
P
M
V
L
E
K
T
S
A
S
KFGIKS
G
E
G
M
F
CY
T
P
E
--
Q
T
K
A
------
L
Q
A
E
---
R
A
R
K
L
V
A
V
R
R
I
L
E
G
R
---
3
PsiBlast_PDB
71.52
30%
-21
- C1 -
-
3ADO
-
CRYL1_RABIT
A:
[11-316]
--------
I
V
G
S
G
L
V
G
R
S
W
A
M
L
F
A
S
G
G
F
R
V
K
L
Y
D
I
E
P
R
Q
I
T
G
A
L
E
N
I
R
K
E
---
M
K
S
L
-------
Q
Q
S
G
S
LKG
S
L
S
A
E
E
Q
L
S
L
I
S
S
C
T
---
N
L
A
E
A
V
E
G
V
V
H
I
Q
E
C
V
P
E
N
L
D
L
K
R
K
I
F
A
Q
L
D
S
I
V
D
D
R
V
V
L
S
S
S
S
S
C
L
L
P
S
K
L
F
T
G
L
A
H
V
K
Q
C
I
V
A
H
P
V
N
P
P
Y
Y
I
P
L
V
E
L
V
P
H
P
E
T
S
P
A
T
V
D
R
T
H
A
L
M
R
K
I
G
Q
S
P
V
R
V
L
K
E
I
D
G
F
V
L
N
R
L
Q
Y
A
I
I
S
E
A
W
R
L
V
E
E
G
I
V
S
P
S
D
L
D
L
V
M
S
D
G
L
G
M
R
Y
A
F
I
G
P
L
E
T
M
H
L
-
N
A
E
G
-------
M
L
S
Y
C
D
R
Y
S
E
G
M
K
R
V
-------
L
--
K
S
--
F
G
S
I
P
E
F
S
G
A
T
V
E
K
------
V
N
Q
A
M
--
C
K
K
--
V
P
A
D
P
E
H
---
L
A
A
R
R
E
W
R
D
E
C
L
K
R
L
A
K
L
K
R
Q
M
---
2
PsiBlast_PDB
70.87
30%
-122
- C1 -
-
4OM8
1
?
A:
[2-248]
---
I
R
N
I
A
I
I
G
L
G
T
M
G
P
G
M
A
A
R
L
A
R
G
G
L
Q
V
V
A
Y
D
V
A
P
A
A
I
E
R
A
R
S
M
L
S
V
A
---
E
T
V
L
D
A
---
L
G
I
A
L
P
S
---
A
G
-----
V
G
T
V
R
F
T
D
---
D
I
G
D
A
V
S
G
A
D
L
V
I
E
N
V
P
E
N
I
S
I
K
A
D
V
Y
R
T
I
D
G
L
I
G
Q
D
T
I
V
A
S
D
T
S
G
I
P
I
T
K
L
Q
A
H
I
S
Y
P
E
R
M
V
G
M
H
W
S
N
P
P
H
I
I
P
M
I
E
V
I
A
G
E
K
T
A
P
Q
T
V
A
T
I
R
D
L
I
R
S
I
G
L
L
P
V
V
V
K
K
D
V
P
G
F
V
E
N
R
V
L
Y
A
L
L
R
E
A
V
D
L
V
E
R
G
V
I
D
P
E
D
L
D
T
C
V
S
W
G
I
G
Y
K
I
A
V
I
G
P
M
A
L
L
D
M
A
G
L
D
I
-------
Y
K
S
V
S
S
F
L
----------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.15
29%
-98
- C1 -
-
4E13
3
?
A:
[1-219]
M
T
G
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
K
R
F
E
-
G
---
L
A
A
V
Y
E
---
K
E
V
A
G
A
A
---
D
G
A
A
Q
K
A
L
G
G
I
R
Y
S
D
---
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
69.04
30%
-32
- C1 -
-
3F3S
5
CRYL1_HUMAN
A:
[5-313]
-----
C
V
V
I
V
G
S
G
V
I
G
R
S
W
A
M
L
F
A
S
G
G
F
Q
V
K
L
Y
D
---
I
E
Q
Q
Q
I
R
N
A
L
E
-
N
---
I
R
K
E
M
K
---
L
L
E
Q
A
G
S
---
L
K
G
S
L
S
V
E
E
Q
L
S
L
I
S
GCP
N
I
Q
E
A
V
E
G
A
M
H
I
Q
E
C
V
P
E
D
L
E
L
K
K
K
I
F
A
Q
L
D
S
I
I
D
D
R
V
I
L
S
S
S
T
S
C
L
M
P
S
K
L
F
A
G
L
V
H
V
K
Q
C
I
V
A
H
P
V
N
P
P
Y
Y
I
P
L
V
E
L
V
P
H
P
E
T
A
P
T
T
V
D
R
T
H
A
L
M
K
K
I
G
Q
C
P
M
R
V
Q
K
E
V
A
G
F
V
L
N
R
L
Q
Y
A
I
I
S
E
A
W
R
L
V
E
E
G
I
V
S
P
S
D
L
D
L
V
M
S
E
G
L
G
M
R
Y
A
F
I
G
P
L
E
T
M
H
L
-
N
A
E
G
M
L
S
Y
C
D
R
Y
S
E
G
I
K
H
V
--------------
L
--
Q
T
--
F
G
P
I
P
E
F
S
R
A
T
A
E
K
------
V
N
Q
D
M
--
C
M
K
--
V
P
D
D
P
E
H
L
A
A
R
R
Q
W
---
R
D
E
C
L
M
R
L
A
K
L
K
S
Q
V
---
9
PsiBlast_PDB
67.69
29%
-98
- C1 -
-
4DYD
9
?
A:
[1-219]
M
T
G
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
K
R
F
E
-
G
---
L
A
A
V
Y
E
---
K
E
V
A
G
A
A
---
D
G
A
A
Q
K
A
L
G
G
I
R
Y
S
D
---
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
66.55
29%
-101
- C1 -
-
4E12
4
?
A:
[1-219]
M
T
G
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
K
R
F
E
-
G
---
L
A
A
V
Y
E
---
K
E
V
A
G
A
A
---
D
G
A
A
Q
K
A
L
G
G
I
R
Y
S
D
---
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
----------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
64.84
25%
-111
- C1 -
-
3MOG
1
PAAH_ECOLI
C:
[3-250]
-
L
N
V
Q
T
V
A
V
I
G
S
G
T
M
G
A
G
I
A
E
V
A
A
S
H
G
H
Q
V
L
L
Y
D
I
S
A
E
A
L
T
R
A
I
D
G
I
H
A
R
---
L
N
S
R
V
T
---
R
G
K
L
T
A
E
-----
T
C
E
R
T
L
K
R
L
I
P
V
T
---
D
I
-
H
A
L
A
A
A
D
L
V
I
E
A
A
S
E
R
L
E
V
K
K
A
L
F
A
Q
L
A
E
V
C
P
P
Q
T
L
L
T
T
N
T
S
S
I
S
I
T
A
I
A
A
E
I
K
N
P
E
R
V
A
G
L
H
F
F
N
P
A
P
V
M
K
L
V
E
V
V
S
G
L
A
T
A
A
E
V
V
E
Q
L
C
E
L
T
L
S
W
G
K
Q
P
V
R
C
-
H
S
T
P
G
F
I
V
N
R
V
A
R
P
Y
Y
S
E
A
W
R
A
L
E
E
Q
V
A
A
P
E
V
I
D
A
A
L
R
D
G
A
G
F
P
---
M
G
P
L
E
L
T
D
L
I
G
Q
D
V
-------
N
F
A
V
T
C
S
V
F
---------------------------------------------------------------------------------------
65
HHSearch
64.53
26%
-108
- C1 -
-
4R1N
-
?
A:
[1-249]
---
M
K
K
V
F
V
L
G
A
G
T
M
G
A
G
I
V
Q
A
F
A
A
K
G
C
E
V
I
V
R
D
I
K
E
E
F
V
D
R
G
I
A
T
I
T
K
S
---
L
S
K
L
V
A
---
K
E
K
I
T
E
A
-----
D
K
E
E
I
L
S
R
I
S
G
T
T
---
D
M
-
K
L
A
A
D
C
D
L
V
V
E
A
A
I
E
N
M
K
I
K
K
E
I
F
A
E
L
D
G
I
C
K
P
E
T
I
L
A
S
N
T
S
S
L
S
I
T
E
V
A
S
A
T
K
R
A
D
K
V
I
G
M
H
F
F
N
P
A
P
V
M
K
L
V
E
V
I
R
G
A
A
T
S
Q
E
T
F
D
A
V
K
E
M
S
E
S
I
G
K
T
P
V
E
V
-
A
E
A
P
G
F
V
V
N
R
I
L
I
P
M
I
N
E
A
T
F
I
L
Q
E
G
V
A
K
E
E
D
I
D
A
A
M
K
L
G
A
N
H
P
---
M
G
P
L
A
L
G
D
L
I
G
L
D
V
-------
C
L
A
I
M
D
V
L
Y
N
E
T
------------------------------------------------------------------------------------
70
HHSearch
63.74
28%
-10
- C1 -
-
4DYD
11
?
A:
[1-251]
M
T
G
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
K
R
F
E
G
L
A
A
V
Y
E
K
E
V
A
---
G
A
--
A
D
G
-----
A
A
Q
K
A
L
G
G
I
R
Y
S
D
---
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
K
T
W
R
I
G
T
G
A
P
---
K
G
P
F
E
I
F
D
I
V
G
L
T
T
-------
A
Y
N
I
S
S
V
S
----------------------------------------------------------------------------------------
64
HHSearch
63.53
23%
-104
- C1 -
-
2X58
1
ECHP_RAT
A:
[300-542]
--
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
---
L
E
K
E
A
S
---
R
A
H
Q
N
G
Q
-------
A
S
A
K
P
K
L
R
F
S
S
---
S
T
K
-
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
-
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
F
K
---
M
G
P
F
R
V
S
D
L
A
G
L
D
V
-------
G
W
K
I
R
K
G
Q
G
---------------------------------------------------------------------------------------
58
HHSearch
63.06
29%
-119
- C1 -
-
1ZEJ
1
?
A:
[12-238]
---
H
M
K
V
F
V
I
G
A
G
L
M
G
R
G
I
A
I
A
I
A
-
S
K
H
E
V
V
L
Q
D
V
S
E
K
A
L
E
A
A
R
E
Q
I
P
E
E
----------------------------
L
L
S
K
I
E
F
T
T
---
T
L
E
-
K
V
K
D
C
D
I
V
M
E
A
V
F
E
D
L
N
T
K
V
E
V
L
R
E
V
E
R
L
-
T
-
N
A
P
L
C
S
N
T
S
V
I
S
V
D
D
I
A
E
R
L
D
S
P
S
R
F
L
G
V
H
W
M
N
P
P
H
V
M
P
L
V
E
I
V
I
S
R
F
T
D
S
K
T
V
A
F
V
E
G
F
L
R
E
L
G
K
E
V
V
V
C
-
K
G
--
Q
S
L
V
N
R
F
N
A
A
V
L
S
E
A
S
R
M
I
E
E
G
V
-
R
A
E
D
V
D
R
V
W
K
H
H
L
G
L
L
Y
T
L
F
G
P
L
G
N
L
D
Y
I
G
L
D
V
-------
A
Y
Y
A
S
L
Y
L
Y
K
--------------------------------------------------------------------------------------
69
HHSearch
62.28
28%
-11
- C1 -
-
4E12
5
?
A:
[1-251]
M
T
G
I
T
N
V
T
V
L
G
T
G
V
L
G
S
Q
I
A
F
Q
T
A
F
H
G
F
A
V
T
A
Y
D
I
N
T
D
A
L
D
A
A
K
K
R
F
E
G
L
A
A
V
Y
E
K
E
V
A
---
G
A
--
A
D
G
-----
A
A
Q
K
A
L
G
G
I
R
Y
S
D
---
D
L
A
Q
A
V
K
D
A
D
L
V
I
E
A
V
P
E
S
L
D
L
K
R
D
I
Y
T
K
L
G
E
L
A
P
A
K
T
I
F
A
T
N
S
S
T
L
L
P
S
D
L
V
G
Y
T
G
R
G
D
K
F
L
A
L
H
F
A
N
H
V
W
V
N
N
T
A
E
V
M
G
T
T
K
T
D
P
E
V
Y
Q
Q
V
V
E
F
A
S
A
I
G
M
V
P
I
E
L
K
K
E
K
A
G
Y
V
L
N
S
L
L
V
P
L
L
D
A
A
A
E
L
L
V
D
G
I
A
D
P
E
T
I
D
K
T
W
R
I
G
T
G
A
P
---
K
G
P
F
E
I
F
D
I
V
G
L
T
T
-------
A
Y
N
I
S
S
V
S
----------------------------------------------------------------------------------------
56
HHSearch
62.20
23%
-109
- C1 -
-
4PZC
-
?
C:
[2-249]
--
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
---
L
D
R
L
I
K
---
K
E
K
L
T
E
A
-----
D
K
A
S
A
L
A
R
I
K
G
S
T
---
S
Y
-
D
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
---
I
G
P
L
A
L
A
D
M
I
G
L
D
T
-------
M
L
A
V
M
E
V
L
Y
T
--------------------------------------------------------------------------------------
57
HHSearch
61.66
23%
-114
- C1 -
-
4PZE
2
?
G:
[2-249]
--
S
I
R
T
V
G
I
V
G
A
G
T
M
G
N
G
I
A
Q
A
C
A
V
V
G
L
N
V
V
M
V
D
I
S
D
A
A
V
Q
K
G
V
A
T
V
A
S
S
---
L
D
R
L
I
K
---
K
E
K
L
T
E
A
-----
D
K
A
S
A
L
A
R
I
K
G
S
T
---
S
Y
-
D
D
L
K
A
T
D
I
V
I
E
A
A
T
E
N
Y
D
L
K
V
K
I
L
K
Q
I
D
G
I
V
G
E
N
V
I
I
A
S
N
T
S
S
I
S
I
T
K
L
A
A
V
T
S
R
A
D
R
F
I
G
M
H
F
F
N
P
V
P
V
M
A
L
V
E
L
I
R
G
L
Q
T
S
D
T
T
H
A
A
V
E
A
L
S
K
Q
L
G
K
Y
P
I
T
V
-
K
N
S
P
G
F
V
V
N
R
I
L
C
P
M
I
N
E
A
F
C
V
L
G
E
G
L
A
S
P
E
E
I
D
E
G
M
K
L
G
C
N
H
P
---
I
G
P
L
A
L
A
D
M
I
G
L
D
T
-------
M
L
A
V
M
E
V
L
Y
T
--------------------------------------------------------------------------------------
68
HHSearch
60.78
20%
-125
- C1 -
-
3K6J
-
?
A:
[53-294]
--
D
V
N
S
V
A
I
I
G
G
G
T
M
G
K
A
M
A
I
C
F
G
L
A
G
I
E
T
F
L
V
V
R
N
E
Q
R
C
K
Q
E
L
E
V
M
------
Y
A
R
E
K
S
---
F
K
R
L
N
D
K
-----
R
I
E
K
I
N
A
N
L
K
I
T
S
---
D
F
-
H
K
L
S
N
C
D
L
I
V
E
S
V
I
E
D
M
K
L
K
K
E
L
F
A
N
L
E
N
I
C
K
S
T
C
I
F
G
T
N
T
S
S
L
D
L
N
E
I
S
S
V
L
R
D
P
S
N
L
V
G
I
H
F
F
N
P
A
N
V
I
R
L
V
E
I
I
Y
G
S
H
T
S
S
Q
A
I
A
T
A
F
Q
A
C
E
S
I
K
K
L
P
V
L
V
-
G
N
C
K
S
F
V
F
N
R
L
L
H
V
Y
F
D
Q
S
Q
K
L
M
Y
E
Y
G
Y
L
P
H
Q
I
D
K
I
I
T
-
N
F
G
F
L
---
M
G
P
M
T
V
A
D
M
N
G
F
D
V
-------
M
E
K
L
K
-------------------------------------------------------------------------------------------
59
HHSearch
59.78
23%
-97
- C- -
-
1ZCJ
-
ECHP_RAT
A:
[294-537]
-
Q
P
V
S
S
V
G
V
L
G
L
G
T
M
G
R
G
I
A
I
S
F
A
R
V
G
I
S
V
V
A
V
E
S
D
P
K
Q
L
D
A
A
K
K
I
I
T
F
T
---
L
E
K
E
A
S
---
R
A
H
Q
N
G
Q
-------
A
S
A
K
P
K
L
R
F
S
S
---
S
T
K
-
E
L
S
T
V
D
L
V
V
E
A
V
F
E
D
M
N
L
K
K
K
V
F
A
E
L
S
A
L
C
K
P
G
A
F
L
C
T
N
T
S
A
L
N
V
D
D
I
A
S
S
T
D
R
P
Q
L
V
I
G
T
H
F
F
S
P
A
H
V
M
R
L
L
E
V
I
P
S
R
Y
S
S
P
T
T
I
A
T
V
M
S
L
S
K
K
I
G
K
I
G
V
V
V
-
G
N
C
Y
G
F
V
G
N
R
M
L
A
P
Y
Y
N
Q
G
F
F
L
L
E
E
G
-
S
K
P
E
D
V
D
G
V
L
E
-
E
F
G
F
K
---
M
G
P
F
R
V
S
D
L
A
G
L
D
V
-------
G
W
K
I
R
K
G
Q
G
---------------------------------------------------------------------------------------
13
PsiBlast_PDB
59.50
25%
-18
* C1 *
-
3HDH
1
HCDH_PIG
A:
[15-288]
---
V
K
H
V
T
V
I
G
G
G
L
M
G
A
G
I
A
Q
V
A
A
A
T
G
H
T
V
V
L
V
D
Q
T
E
D
I
L
A
K
S
K
K
G
I
E
E
S
---
L
R
K
V
A
K
K
K
F
A
E
N
P
K
A
G
---
D
E
F
V
E
K
T
L
S
S
I
S
T
S
T
---
D
A
A
S
V
V
H
S
T
D
L
V
V
E
A
I
V
E
N
L
K
V
K
S
E
L
F
K
R
L
D
K
F
A
A
E
H
T
I
F
A
S
N
T
S
S
L
Q
I
T
S
L
A
N
A
T
T
R
Q
D
R
F
A
G
L
H
F
F
N
P
V
P
L
M
K
L
V
E
V
V
K
T
P
M
T
S
Q
K
T
L
E
S
L
V
D
F
S
K
T
L
G
K
H
P
V
S
C
-
K
D
T
P
G
F
I
V
N
R
L
L
V
P
Y
L
I
E
A
V
R
L
Y
E
R
G
D
A
S
K
E
D
I
D
T
A
M
K
L
G
A
G
Y
P
M
---
G
P
F
-------------------
E
L
L
D
Y
V
G
L
D
T
T
K
F
I
I
D
G
W
H
E
M
D
S
Q
N
PL
F
Q
P
S
P
A
M
N
K
L
V
A
E
N
-----------------------------------------------------