@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRT5: (2017-12-04 )
MKRAGTGQKRNRSIFRFSTLAFAMHVVSMGGLVVFPMQQAYAETAGVKSYNIPAGRLANVLNQFAEQSGTSIAMDAQQLQGLHSLGLKGNFAVEQGFEQLLKATEFNAVKVGQGYTLSKKSMPRVTTSNVQAASLPPSSAVIEEDASVRLTPIVVYGKEDRDTEGYNKVYDANRSSVYAGKDYVERFKGTNPADVLQGMVGVYSGDARNSGALDPSVRGVQGVGRVPLTIDGTEQSIAVWRGYNGVNNRNYIDPNLIAGIEVIKGPSLERNTTTSVGGGVVVKTLEADDIVRPGKSFGAELKVEGSTNSIDPSLPDMSKVGQNYDDTTPWIDMNGSKYDPDIYKKNRTRSDNSHFSGDDLAGRLAIATKQDKFDLLAVYAVRERGNYFSGTHGAGYYKRATPDSSLDFIPYFAYAYQPGDEVPNTSSHMESWLLKGTYRPTDDQTLKLTYRDTKNIFGEIMPSRIVWGITPDLGVPQWPLSNIHSKAYSLEYKFKPENNRWIDFYANIWQTDTESQTYTRGGWPTTIDFRDNTIINTAISHSDNTRKGITVSNKTRLLDQLDLTLGGSFLKEKLTSDDVYGEFGPSYSLYQALPRAGHREEKTFDFNFNYRPVSWLSFDAGMRYRSYWAIDDFLNKSLQSEIDPSLNPLFTKKSRLKEYTFEYQTMPESYTSTQQRLINVLKQRYATKNPEWDGQLDTVPASESTLYNMIWSQKNTLSWKADANGQLSLADNPLNQLNASGPKYVVTGGNFMSVVDQVPVESADKVKDSGWAPQLGASIHLTPNSRIYARYAEEYRLPSLFESTVGFSAMLQYQAIKPEHAFNYEVGYVYDMRDWFSTARNADIKLAYYYNKTKNVIERDQNLIFTNMDEQKLSGLELQSRFDNGGFFTDLSVAYNLKNEVCDTNSAINKMILGGTVQTEQGLEFREPYQRCVDDGFPNGYLVTMATPELSFHGLLGARFFDEKLELGARATFYKAYESPLRKNNDASVNKGYYLNVPLAWDDTWIFDAYARYQVDDYNTVEFVGSNLSNQFYIDPLTRSAMAAPGRTMKISWTTKF
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130......--.140.......150.......160----------------.......170.......180.......-190.......200......--.----210--.........220.--......230.......--------240.--------......250.......260.......270.......280.......290.-......300.......310.......320.......330.......340.......350.......360.......---370.......380...---....390--......-----------...400....--------...410---------.........---420.......430.......440-.......450.......--460..----..--------.---.---.-----470--.----------------------------------.-.-----..--.--...-----------------------480.......490.......500.......510.......520.-....---------...530...-.....540...--....550..--.----.--.---.-.560...--....570.......580.------------.--.-------------------.------------------------.--------.-------------.---.------------------590---.........600.......610..-.....620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770..---------------.....780-.......790.......800......----------------.810..-----.....820.......830-----...-.....840.......850.......860-.------------------------.......870.......880...-------....890.......900.......910.......920...-----....------930.......-940.....---..950.......960---.--......970.......980...--..--..990-........1000......1010..--.------...1020......1030.....-----------------.-1040......1050....--
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKRAGTGQKRN
R
S
I
F
R
F
S
T
L
A
F
A
M
H
V
V
SMG
G
L
V
V
F
P
M
Q
Q
A
Y
A
ETAGVKSYNI
P
A
G
R
L
A
N
V
L
N
Q
F
A
E
QSG
T
S
I
AM
D
A
Q
Q
L
Q
G
L
H
SLGLKGN
F
A
V
E
Q
G
F
E
Q
L
L
K
ATEF
N
A
V
K
VGQ
G
Y
TLSKKSMPRVTTSNVQAASLPPS--S
A
V
IEEDA
S
V
R
L
T
P
I
V
V
YGKEDRD----------------TEGY
N
K
VYDANRSSVYA
G
K
D
Y
V
E
R
FKG-T
N
P
A
D
V
L
Q
G
M
V
G
VYSGDAR--N----S----GALDPSVRGVQGV--GRV
P
L
T
IDGTEQ
S
I
A
V
--------
W
RGY--------NGVNNRNYID
P
N
L
I
A
G
I
E
V
IKGPSLERNTTTSVGG
G
V
V
V
K
TLEADDIVRP-GKSFG
A
E
L
K
VEGSTNSIDPSLP
D
M
S
K
VGQNYDDTT
P
W
I
DMNGSKYDP
D
I
Y
KKNRTRSDNSHFSGDDLA
G
R
L
A
I
ATK---QDK
F
D
L
L
A
V
Y
A
V
R
ERG---NYFSG----THGAG
Y
-----------
Y
KRATPDSSL--------DF
I
P
-----------
Y
F
A
Y
A
YQPG---DEVPN
T
S
S
H
M
E
S
W
L
L
KGTYRPTD-D
Q
T
L
K
L
T
YR
D
T
K
N
I
F
G
E
--IMPS
R
----
I
V
--------
W
---G---I-----T----P----------------------------------D-L-----GV--P--QW
P
-----------------------
L
S
N
IHSK
A
Y
S
L
E
Y
K
FKPENN
R
W
I
D
F
Y
A
N
I
WQTDTESQ
T
Y
TRG-G-W
P
T
T
---------
I
D
FRD-N
T
I
-
I
N
T
A
ISHSDNT--RK
G
I
T
VS
N
K
--
T
----
R
--
L
---
L
-
D
Q
L
D
L
TL--
G
G
S
F
L
K
E
KLTSDDVY-GE------------F--G-------------------P------------------------S--------
Y
-------------
S
---
L
------------------
Y
-----
Q
A
L
PRAGHREE
K
T
F
D
F
NFNYR
P
V
S
-
W
L
SFDAG
M
R
Y
R
S
Y
W
A
I
D
D
F
L
N
K
S
L
Q
S
EIDPSLN
P
L
F
T
K
K
S
R
L
K
E
Y
T
F
E
Y
QTMPESY
T
S
T
Q
Q
R
L
I
N
V
L
K
Q
R
YATKNPEWDGQLDTVPASE
S
T
L
Y
N
M
I
WSQKN
T
L
S
W
KADANG
Q
L
S
LADN
P
L
N
QLNASGP
K
Y
V
V
TGG
N
F
M
S
V
V
D
QVPVE
S
A
DKVKDSGWAPQ---------------L
G
A
S
I
H
LT-PNS
R
I
Y
A
R
Y
A
E
EYR
L
P
S
L
F
E
S
T
V
G
F
S
----------------
A
M
L
Q
YQ-----AIKPEHAFNYEV
G
Y
V
Y
D
------
M
R
D
-
W
F
S
TARNA
D
I
K
L
A
Y
Y
YNK
T
K
N
V
I
E
RDQ--
N
------------------------
L
I
FTNM
D
E
Q
KLSG
L
E
L
Q
S
RFDNG-------
G
F
F
T
D
L
S
V
A
YNLKNEVCD
T
N
S
A
I
N
K
M
I
LG
G
T
V
QTEQGL
E
F
-----
R
E
P
Y
------
Q
R
C
V
DDGFPN-
G
Y
L
V
T
MAT---PE
L
S
F
H
G
L
L
G
A
R
F
F
D
---
E
--
K
L
ELGA
R
A
T
F
Y
K
A
Y
E
SPLRKNN--DA--SVNK--
G
Y
Y
L
N
V
P
LAWDD
T
W
I
F
D
A
Y
A
R
Y
QV--D------DY
N
T
V
E
F
V
GSNLSN
Q
F
Y
IDPL
T
-----------------
R
-SAMAAPG
R
T
M
K
I
S
W
T
TKF--
33
HHSearch
65.69
25%
30
- C3 -
-
3CSL
3
?
B:
[113-865]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
W
V
Y
D
E
P
R
S
V
S
V
I
S
R
E
Q
M
D
N
R
P
A
-
R
H
A
A
D
I
L
E
Q
T
T
G
A
Y
S
S
V
S
Q
--
Q
----
D
----
P
A
L
S
V
N
I
R
G
I
Q
D
Y
--
G
R
V
N
M
N
I
D
G
M
R
Q
N
F
Q
K
--------
S
G
-
H
--------
G
Q
R
N
G
T
M
Y
I
D
S
E
L
L
S
G
V
T
I
D
K
G
T
T
G
G
M
G
S
A
G
T
L
G
G
I
A
T
F
N
T
V
S
A
S
D
F
L
A
P
-
G
K
E
L
G
G
K
L
H
A
S
T
G
D
N
G
T
H
F
----------------------------------------------
I
G
S
G
I
L
--
A
L
G
---
N
E
T
G
D
I
L
L
A
A
S
E
R
H
L
G
---
D
Y
W
P
G
----
N
K
G
D
I
G
-----------
N
I
R
I
N
N
D
-
T
G
--------
N
Y
D
R
-----------
Y
A
-
E
S
-
I
K
N
---
N
K
I
P
D
T
H
Y
R
M
H
S
R
L
A
K
V
G
W
N
L
P
A
-
N
Q
R
L
Q
L
S
Y
L
Q
T
Q
T
A
S
P
I
----
A
G
T
----
L
T
--------
N
---
L
---
G
-----
T
----
R
----------------------------------
P
-
P
-----
Y
E
--
L
--
G
W
K
RTG--------------------
Y
T
D
V
M
A
R
N
A
A
F
D
Y
S
L
A
P
E
D
V
D
W
L
D
F
Q
A
K
L
Y
Y
V
D
T
Q
D
D
S
D
T
Y
S
-
T
-
S
S
L
L
---------
D
----------
N
G
Y
A
T
R
T
R
L
R
--
T
Y
G
A
Q
A
Q
N
T
--
S
----
R
FS
L
AP-
G
-
H
D
F
R
A
N
Y
--
G
L
E
F
Y
Y
D
K
A
T
S
D
S
S
R
-
Q
G
------------
M
---------------------------------------------------------------------------------------------------
E
G
V
T
P
A
G
N
R
S
V
A
S
L
F
A
N
L
T
Y
D
Y
D
G
-
W
L
T
L
E
G
G
L
R
Y
D
R
Y
R
L
R
G
Q
T
G
L
S
Y
P
D
L
A
K
-----------------------
D
G
-----
Q
R
Y
T
I
D
N
P
----------
C
----------
K
---------------
A
-------------------------
L
R
L
T
G
C
S
T
-----
T
T
R
E
D
W
D
V
D
R
D
Q
G
K
L
S
P
T
---------------
L
A
V
A
V
R
P
G
V
E
W
L
E
L
Y
T
T
Y
G
K
S
W
R
P
P
A
I
T
E
T
L
T
N
G
S
AHSSS-----------
T
Q
Y
P
N
P
-----
F
L
Q
P
E
R
S
R
A
W
E
V
G
F
N
V
Q
------
Q
P
D
L
W
F
-
E
G
D
R
L
V
A
K
V
A
Y
F
D
T
K
V
D
N
Y
I
N
L
A
I
--
D
RNKPGLVQPSIGNA----------
A
Y
V
N
N
L
S
K
T
R
F
R
G
L
E
Y
Q
L
N
Y
D
A
G
-------
V
F
Y
A
D
L
T
Y
T
H
M
I
-
G
K
N
E
F
C
S
N
K
---
A
W
L
G
G
R
L
-
R
Y
G
D
G
S
R
RGNFY
V
E
P
D
AASNDF
V
T
C
D
-
G
G
T
Q
F
-
G
S
A
--
A
Y
L
---
P
G
D
R
G
S
V
T
L
G
G
R
A
F
D
---
R
--
K
L
D
A
G
V
T
V
R
F
A
P
G
Y
Q
D
S
S
V
P
S
N
---------------
Y
P
Y
L
A
D
W
P
K
Y
T
L
F
D
L
Y
A
S
Y
K
L
--
T
------
D
S
L
T
L
R
G
S
V
E
N
L
T
N
R
A
Y
V
V
S
Y
G
ET---------------
L
-
A
N
T
L
G
R
G
R
T
V
Q
G
G
V
E
Y
R
F
--
21
Fugue
64.31
22%
24
- C3 -
-
3CSL
6
?
A:
[113-865]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
D
W
V
Y
D
E
P
R
S
V
S
V
I
S
R
E
Q
M
D
N
R
P
A
-
R
H
A
A
D
I
L
E
Q
T
T
G
A
Y
S
S
V
S
Q
--
Q
----
D
----
P
A
L
S
V
N
I
R
G
I
Q
D
Y
--
G
R
V
N
M
N
I
D
G
M
R
Q
N
F
Q
---------
K
S
G
H
--------
G
Q
R
N
G
T
M
Y
I
D
S
E
L
L
S
G
V
T
I
D
K
G
T
T
G
G
M
G
S
A
G
T
L
G
G
I
A
T
F
N
T
V
S
A
S
D
F
L
A
P
-
G
K
E
L
G
G
K
L
H
A
S
T
G
D
N
------------------------------------------------
G
T
H
F
I
G
S
G
I
L
A
L
G
---
N
E
T
G
D
I
L
L
A
A
S
E
R
H
L
G
---
D
Y
W
P
G
----
N
K
G
D
I
G
-----------
N
I
R
I
N
N
D
T
G
N
--------
Y
D
R
Y
-----------
A
E
S
I
K
N
N
K
------
I
P
D
T
H
Y
R
M
H
S
R
L
A
K
V
G
W
N
L
P
A
-
N
Q
R
L
Q
L
S
Y
L
Q
T
Q
T
A
S
P
I
--
A
G
T
L
T
----
N
L
--------
G
---
T
---
R
-----
P
----
P
Y
---------------------------------
E
-
L
-----
G
W
--
K
--
R
T
G
-----------------------
Y
T
D
V
M
A
R
N
A
A
F
D
Y
S
L
A
P
E
D
V
D
W
L
D
F
Q
A
K
L
Y
Y
V
D
T
Q
D
D
S
D
T
Y
S
-
T
-
S
S
L
L
---------
D
N
G
Y
A
-
T
R
T
-
R
L
R
T
Y
G
A
Q
A
Q
N
--
T
S
R
F
S
L
A
P
G
----------------
H
D
F
R
A
N
Y
--
G
L
E
F
Y
Y
D
K
A
T
S
D
S
-
S
-
R
Q
------------
G
--
M
-------------------
E
------------------------
G
--------
V
-------------
T
---
P
------------------
A
-----
G
N
R
S
V
A
S
L
F
A
N
L
T
Y
D
Y
D
------
G
-
W
L
T
L
E
G
G
L
R
Y
D
R
Y
R
L
R
G
Q
T
G
L
S
Y
P
D
L
A
K
D
G
Q
R
Y
T
I
D
N
P
C
K
A
L
R
L
T
G
C
S
T
T
T
R
E
D
W
D
V
D
R
D
Q
G
K
L
S
P
T
L
A
V
A
V
R
P
G
V
E
W
------------------------------------------------------------------------------------------------------------
L
E
L
Y
T
T
Y
G
K
S
W
R
P
P
A
I
T
E
T
L
T
N
G
S
----------------
A
H
S
S
S
T
Q
Y
P
N
P
F
L
Q
P
E
R
S
R
A
W
E
V
G
F
N
V
Q
------
Q
P
D
-
L
W
F
E
G
D
R
L
V
A
K
V
A
Y
F
D
T
K
V
D
N
Y
I
N
L
A
I
--
D
RNKPG
L
V
Q
P
S
IGN
A
----------
A
Y
V
N
N
L
S
K
T
R
F
R
G
L
E
Y
Q
L
N
Y
D
A
G
-------
V
F
Y
A
D
L
T
Y
T
H
M
I
G
K
N
E
F
C
S
N
K
A
W
L
G
G
R
L
R
Y
G
D
G
S
R
R
G
N
F
Y
-----
V
E
P
D
------
A
A
S
N
D
F
V
T
C
D
-
G
G
T
Q
F
G
S
A
AYL
P
G
D
R
G
S
V
T
L
G
G
R
A
F
D
---
R
--
K
L
D
A
G
V
T
V
R
F
A
P
G
Y
Q
D
S
S
V
P
S
N
--
Y
P
--
Y
-----------
L
A
D
W
P
K
Y
T
L
F
D
L
Y
A
S
Y
K
L
--
T
------
D
S
L
T
L
R
G
S
V
E
N
L
T
N
R
A
Y
V
V
S
Y
G
ET---------------
L
-
A
N
T
L
G
R
G
R
T
V
Q
G
G
V
E
Y
R
F
--
22
Fugue
50.92
15%
26
- C3 -
-
2IAH
1
FPVA_PSEAE
A:
[1-772]
---------------------------------------------
Q
E
V
E
F
D
I
P
P
Q
A
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
V
A
T
----
I
T
E
D
S
G
S
Y
T
P
G
T
I
--
A
T
A
T
R
L
V
L
T
P
R
E
T
P
-------------------------------------
Q
S
I
T
V
V
T
R
Q
N
M
D
D
F
G
L
-
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
S
A
Y
D
--
T
------------
D
R
N
N
Y
Y
A
R
G
F
--
S
I
N
N
F
Q
Y
D
G
I
P
S
T
A
R
N
--------
V
G
Y
S
--------
A
G
---
N
T
L
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
A
G
S
L
G
A
T
I
N
L
I
R
K
------
K
P
-
T
H
E
F
K
G
H
V
E
L
G
A
G
----------------
S
W
D
N
Y
R
S
E
L
D
V
S
G
P
L
T
E
S
G
---
N
V
R
G
R
A
V
A
A
Y
Q
D
K
H
S
F
M
D
H
Y
--------
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
---
P
D
T
M
L
----
T
V
G
A
D
Y
-----------
Q
D
N
D
P
K
G
S
G
----------
W
S
G
-----------
S
F
P
L
F
D
S
Q
G
---
N
R
N
D
V
S
R
S
F
N
N
G
--------------------------------------------------------------------------------------------------------------------
A
--
K
W
S
-----------------------
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
A
N
G
W
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
A
I
M
-
G
-
D
W
P
A
---------
P
D
N
S
A
-
K
I
V
-
A
Q
K
Y
T
G
E
T
K
S
N
--
S
L
D
I
Y
L
T
G
P
--
F
----
Q
--
F
---
L
-
G
R
E
H
E
L
V
--
V
G
T
S
A
S
F
S
H
W
E
G
K
S
Y
-
W
N
------------
L
--
R
-------------------
N
------------------------
Y
--------
D
-------------
N
---
T
------------------
T
-----
D
D
F
I
N
W
D
G
D
I
G
K
------------------------------------------
P
D
W
G
T
P
S
Q
Y
I
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
D
L
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
G
L
-----------------------------------------------------------------------
N
P
T
I
R
E
S
G
R
F
I
P
Y
---------------
V
G
A
V
Y
D
L
N
-
D
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
Q
D
S
W
Y
R
D
S
S
----------------------
N
K
-----
L
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
------
Y
L
D
------
G
R
L
N
T
S
L
A
Y
F
E
I
H
E
E
N
R
A
E
E
D
A
--
L
------------------------
Y
N
S
K
P
T
N
P
A
I
-
T
Y
A
Y
K
G
I
K
A
K
T
K
-------
G
Y
E
A
E
I
S
----------------------
G
E
L
A
P
G
W
Q
V
Q
A
-----
G
Y
T
H
------
K
I
I
R
D
---
D
S
-
G
K
K
V
S
T
W
E
---
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
---
A
LD
K
L
T
V
G
G
G
A
R
W
Q
G
K
S
W
Q
M
V
Y
N
N
P
--
R
S
--
R
W
E
K
--
F
S
Q
-------
E
D
Y
W
L
V
D
L
M
A
R
Y
Q
I
--
T
------
D
K
L
S
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
-----------------
F
-
Y
T
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
R
W
D
F
39
HHSearch
49.38
17%
33
- C3 -
-
4B7O
-
?
A:
[61-745]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
Q
--------------------------
G
S
K
I
R
T
N
I
V
T
L
Q
Q
K
D
E
S
T
A
-
T
D
M
R
E
L
L
K
E
E
P
S
I
D
F
G
G
G
N
-------
G
----
T
S
Q
F
L
T
L
R
G
M
G
Q
---
N
S
V
D
I
K
V
D
N
A
Y
S
D
S
Q
I
--------
L
Y
------------
H
Q
G
R
F
I
V
D
P
A
L
V
K
V
V
S
V
Q
K
G
A
G
S
A
S
A
G
I
G
A
T
N
G
A
I
I
A
K
T
V
D
A
Q
D
L
L
K
G
L
D
K
N
W
G
V
R
L
N
S
G
F
A
S
N
E
G
-------------------------------------------------
V
S
Y
G
A
S
V
F
G
K
---
E
G
N
F
D
G
L
F
S
Y
N
R
N
D
E
K
---
E
Y
E
A
G
----
K
G
F
---------------
R
-
N
F
N
----------------------------------
G
G
---
K
T
V
P
Y
S
A
L
D
K
R
S
Y
L
A
K
I
G
T
T
F
G
D
G
D
H
R
I
V
L
S
H
M
E
D
Q
H
R
G
I
R
--
T
V
R
E
E
----
F
T
--------
V
----------------------------------------------------------------------
P
-----------------------
Y
R
E
T
T
Q
S
N
T
N
L
A
Y
T
G
K
D
L
G
-
F
V
E
K
L
D
A
N
A
Y
V
L
E
K
K
R
Y
S
A
D
D
K
-
D
-
N
G
Y
A
-----------------
G
-
N
V
V
G
P
N
H
T
R
I
T
--
T
R
G
M
N
F
N
F
D
--
S
----
R
--
L
---
A
-
E
Q
T
L
L
K
Y
--
G
I
N
Y
R
H
Q
E
I
K
P
Q
A
F
L
-
N
G
------------
E
--
F
EIS---------------------------------------------------TDEEK
A
K
D
K
K
D
M
D
L
---
V
------------------
H
-----
S
Y
K
L
S
N
P
T
K
T
D
T
G
A
Y
I
E
A
I
H
E
L
-
D
-
G
F
T
L
T
G
G
L
R
Y
D
R
F
K
V
K
T
H
D
---------------------------------------------------------------------------------------------------------------------------------
G
K
T
V
S
S
S
N
L
N
P
S
---------------
F
G
V
I
W
Q
P
H
-
E
H
W
S
F
S
S
S
H
N
Y
A
S
R
S
P
R
L
Y
D
A
L
Q
T
H
G
KR
G
-------------
I
I
S
I
A
D
-----
G
T
K
A
E
R
A
R
N
T
E
I
G
F
N
Y
N
------
D
--------
G
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
P
Q
--
N
AV----------------------
R
E
A
V
N
A
G
Y
I
K
N
H
G
Y
E
L
G
A
S
Y
R
T
G
-------
G
L
T
A
K
V
G
V
S
H
S
K
-
P
R
F
Y
D
T
H
P
----------------
K
K
----------------------
L
L
S
--
A
N
P
E
F
G
A
Q
---
V
G
R
A
W
T
A
S
L
A
Y
R
F
Q
N
---
P
--
N
L
E
I
G
W
R
G
R
Y
V
Q
K
A
V
G
S
I
L
V
A
G
--
Q
K
-----
D
--
R
--
K
L
E
N
V
V
R
K
G
F
G
V
N
D
V
F
A
N
W
K
P
LG
K
------
D
T
L
N
V
N
L
S
V
N
N
V
F
N
T
F
Y
Y
P
H
S
Q
RW---------------
T
-
N
T
L
P
G
V
G
R
D
V
R
L
G
V
N
Y
K
F
--
38
HHSearch
48.56
17%
38
- C3 -
-
4AIP
1
?
B:
[60-742]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
R
Q
--------------------------
G
S
K
I
R
T
N
I
V
T
L
Q
Q
K
D
E
S
T
A
-
T
D
M
R
E
L
L
K
E
E
P
S
I
D
F
G
G
G
N
-------
G
----
T
S
Q
F
L
T
L
R
G
M
G
Q
---
N
S
V
D
I
K
V
D
N
A
Y
S
D
S
Q
I
--------
L
Y
------------
H
Q
G
R
F
I
V
D
P
A
L
V
K
V
V
S
V
Q
K
G
A
G
S
A
S
A
G
I
G
A
T
N
G
A
I
I
A
K
T
V
D
A
Q
D
L
L
K
G
L
D
K
N
W
G
V
R
L
N
S
G
F
A
S
N
N
G
-------------------------------------------------
V
S
Y
G
A
S
V
F
G
K
---
E
G
N
F
D
G
L
F
S
Y
N
R
N
D
E
K
---
D
Y
E
A
G
----
K
G
F
---------------
R
--
N
V
--
N
-------------------------------
G
G
---
K
T
V
P
Y
S
A
L
D
K
R
S
Y
L
A
K
I
G
T
T
F
G
D
D
D
H
R
I
V
L
S
H
M
K
D
Q
H
R
G
I
R
--
T
V
R
E
E
----
F
T
--------
V
---
G
---
D
-----
K
----
S
S---------------------------------
R
-
I
-----
N
I
DR
Q
--
A
P
A
-----------------------
Y
R
E
T
T
Q
S
N
T
N
L
A
Y
T
G
K
N
L
G
-
F
V
E
K
L
D
A
N
A
Y
V
L
E
K
E
R
Y
S
A
D
D
S
-
G
-
T
G
Y
A
-----------------
G
-
N
V
K
G
P
N
H
T
R
I
T
--
T
R
G
A
N
F
N
F
D
--
S
----
R
--
L
---
A
-
E
Q
T
L
L
K
Y
--
G
I
N
Y
R
H
Q
E
I
K
P
Q
A
F
L
-
N
S
------------
K
--
F
S-----------------------------------------------------EQQ
M
K
D
R
A
D
E
D
--
T
---
V
------------------
H
-----
A
Y
K
L
S
N
P
T
K
T
D
T
G
V
Y
I
E
A
I
H
D
I
G
--
D
F
T
L
T
G
G
L
R
Y
D
R
F
K
V
K
T
H
D
---------------------------------------------------------------------------------------------------------------------------------
G
K
T
V
S
S
S
N
L
N
P
S
---------------
F
G
V
I
W
Q
P
H
-
E
H
W
S
F
S
A
S
H
N
Y
A
S
R
S
P
R
L
Y
D
A
L
Q
T
H
G
KR
G
-------------
I
I
S
I
A
D
-----
G
T
K
A
E
R
A
R
N
T
E
I
G
F
N
Y
N
------
D
--------
G
T
F
A
A
N
G
S
Y
F
W
Q
T
I
K
D
A
L
A
N
P
Q
--
N
RSVA
V
-------------------
R
E
A
V
N
A
G
Y
I
K
N
H
G
Y
E
L
G
A
S
Y
R
T
G
-------
G
L
T
A
K
V
G
V
S
H
S
K
-
P
R
F
Y
D
T
H
K
----------------
D
K
----------------------
L
L
S
A
--
N
P
E
F
G
A
Q
---
V
G
R
T
W
T
A
S
L
A
Y
R
F
Q
N
---
P
--
N
L
E
I
G
W
R
G
R
Y
V
Q
K
A
T
G
S
I
L
A
A
G
---
Q
--
K
--
D
--
R
K
G
N
L
E
N
V
V
R
K
G
F
G
V
N
D
V
F
A
N
W
K
P
--
L
GK----
D
T
L
N
V
N
L
S
V
N
N
V
F
N
K
F
Y
Y
P
H
S
Q
RW---------------
T
-
N
T
L
P
G
V
G
R
D
V
R
L
G
V
N
Y
K
F
--
32
HHSearch
47.72
14%
30
* C3 *
-
2W16
2
FPVA_PSEAE
A:
[2-772]
----------------------------------------------
E
V
E
F
D
I
P
P
Q
A
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
V
A
E
A
A
D
S
S
V
-
D
L
G
A
-
T
M
I
T
S
NQ
L
G
T
I
T
E
D
S
G
S
Y
T
P
G
T
I
A
T
A
T
R
L
V
---------------------
L
T
P
R
E
T
P
Q
S
I
T
V
V
T
R
Q
N
M
D
D
F
G
L
-
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
S
A
Y
D
--
T
---------
D
R
N
N
Y
Y
A
R
G
F
S
I
-----
N
N
F
Q
Y
D
G
I
P
S
T
A
R
N
--------
V
G
-
Y
----------
S
A
G
N
T
L
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
A
G
S
L
G
A
T
I
N
L
I
R
K
K
P
T
H
-------
E
F
K
G
H
V
E
L
G
A
G
S
W
D
N
Y
-------------------------------------------------
R
S
E
L
D
V
S
G
P
LTE
S
G
N
V
R
G
R
A
V
A
A
Y
Q
D
K
H
---
S
F
M
D
-----------------------------------------------------------------------
H
Y
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
P
-
D
T
M
L
T
V
G
A
D
Y
Q
D
N
D
P
K
G
--
S
G
W
S
G
SFPL
F
D
--------
S
---
Q
---
G
N
----
R
----
N
D
V
S
R------------------------------
S
-
F
N----
N
G
--
A
--
K
W
S
-----------------------
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
A
N
-
G
W
-
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
A
-
I
-
M
G
D
W
---------
P
A
P
D
N
-
S
A
K
-
I
V
A
Q
K
Y
T
G
E
T
K
--
S
N
S
L
D
I
Y
L
T
--
G
----
P
--
F
Q
F
L
G
-
R
E
H
E
L
V
V
--
G
T
S
A
S
F
S
H
W
E
G
K
S
Y
W
-
N
L
RNYDNTTDDFIN
W
--
D
-------------------
G
------------------------
D
I
G
------
K
-------------
P
DW-
G
------------------
T
-----
P
S
Q
Y
I
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
L
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
G
L
N
---------------------------------------------------------------------------------------------------------------------------------
P
T
I
R
E
S
G
R
F
I
P
Y
---------------
V
G
A
V
Y
D
L
N
-
D
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
Q
D
S
W
Y
R
----------------------
D
S
S
N
K
-----
L
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
------
Y
L
D
------
G
R
L
N
T
S
L
A
Y
F
E
I
H
E
E
N
R
A
E
E
D
A
--
L
Y
N
S
KPTNPAI--------------
T
Y
A
Y
K
G
I
K
A
K
T
K
G
Y
E
A
E
I
S
G
E
L
A
P------
G
W
Q
V
Q
A
G
Y
T
H
K
I
-
I
R
D
D
S
----------------------------------------------
G
-
K
K
V
-
S
T
W
E
---
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
AL-
D
--
K
L
T
V
G
G
G
A
R
W
Q
G
K
S
W
Q
M
V
Y
N
N
P
-------------
R
S
R
W
E
K
F
S
Q
E
D
Y
W
L
V
D
L
M
A
R
Y
Q
I
--
T
------
D
K
L
S
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
FY---------------
T
-
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
R
W
D
F
--
31
HHSearch
47.68
14%
31
- C3 -
-
2W75
2
FPVA_PSEAE
A:
[2-772]
----------------------------------------------
E
V
E
F
D
I
P
P
Q
A
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
V
A
E
A
A
D
S
S
V
-
D
L
G
A
-
T
M
I
T
S
NQ
L
G
T
I
T
E
D
S
G
S
Y
T
P
G
T
I
A
T
A
T
R
L
V
---------------------
L
T
P
R
E
T
P
Q
S
I
T
V
V
T
R
Q
N
M
D
D
F
G
L
-
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
S
A
Y
D
--
T
---------
D
R
N
N
Y
Y
A
R
G
F
S
I
-----
N
N
F
Q
Y
D
G
I
P
S
T
A
R
N
--------
V
G
-
Y
----------
S
A
G
N
T
L
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
A
G
S
L
G
A
T
I
N
L
I
R
K
K
P
T
H
-------
E
F
K
G
H
V
E
L
G
A
G
S
W
D
N
Y
-------------------------------------------------
R
S
E
L
D
V
S
G
P
LTE
S
G
N
V
R
G
R
A
V
A
A
Y
Q
D
K
H
---
S
F
M
D
-----------------------------------------------------------------------
H
Y
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
P
-
D
T
M
L
T
V
G
A
D
Y
Q
D
N
D
P
K
G
--
S
G
W
S
G
SFPL
F
D
--------
S
---
Q
---
G
N
----
R
----
N
D
V
S
R------------------------------
S
-
F
N----
N
G
--
A
--
K
W
S
-----------------------
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
A
N
-
G
W
-
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
A
-
I
-
M
G
D
W
---------
P
A
P
D
N
-
S
A
K
-
I
V
A
Q
K
Y
T
G
E
T
K
--
S
N
S
L
D
I
Y
L
T
--
G
----
P
--
F
Q
F
L
G
-
R
E
H
E
L
V
V
--
G
T
S
A
S
F
S
H
W
E
G
K
S
Y
W
-
N
L
RNYDNTTDDFIN
W
--
D
-------------------
G
------------------------
D
I
G
------
K
-------------
P
DW-
G
------------------
T
-----
P
S
Q
Y
I
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
L
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
G
L
N
---------------------------------------------------------------------------------------------------------------------------------
P
T
I
R
E
S
G
R
F
I
P
Y
---------------
V
G
A
V
Y
D
L
N
-
D
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
Q
D
S
W
Y
R
----------------------
D
S
S
N
K
-----
L
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
------
Y
L
D
------
G
R
L
N
T
S
L
A
Y
F
E
I
H
E
E
N
R
A
E
E
D
A
--
L
Y
N
S
KPTNPAI--------------
T
Y
A
Y
K
G
I
K
A
K
T
K
G
Y
E
A
E
I
S
G
E
L
A
P------
G
W
Q
V
Q
A
G
Y
T
H
K
I
-
I
R
D
D
S
----------------------------------------------
G
-
K
K
V
-
S
T
W
E
---
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
AL-
D
--
K
L
T
V
G
G
G
A
R
W
Q
G
K
S
W
Q
M
V
Y
N
N
P
-------------
R
S
R
W
E
K
F
S
Q
E
D
Y
W
L
V
D
L
M
A
R
Y
Q
I
--
T
------
D
K
L
S
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
FY---------------
T
-
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
R
W
D
F
--
35
HHSearch
47.61
19%
26
- C3 -
-
3FHH
1
?
A:
[2-640]
--------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
M
T
V
T
A
T
G
N
A
---------------------
R
S
S
F
E
A
P
M
M
V
S
V
I
D
T
S
A
P
E
N
Q
T
A
-
T
S
A
T
D
L
L
R
H
V
P
G
I
T
L
D
G
T
G
--
R
----
T
----
N
G
Q
D
I
N
M
R
G
Y
D
H
---
R
G
V
L
V
L
V
D
G
I
R
Q
G
T
D
T
--------
G
--
H
-----------
L
N
G
T
F
L
D
P
A
L
I
K
R
V
E
I
V
R
G
P
S
A
L
L
Y
G
S
G
A
L
G
G
V
I
S
Y
D
T
V
D
A
K
D
L
L
Q
E
-
G
Q
S
S
G
F
R
V
F
G
T
G
G
T
G
D
H
------------------------------------------------
S
L
G
L
G
A
S
A
F
G
R
---
T
E
N
L
D
G
I
V
A
W
S
S
R
D
R
G
---
D
L
R
Q
S
-----
N
G
-----------------------------------------------------------
E
T
-
A
P
N
D
E
S
I
N
N
M
L
A
K
G
T
W
Q
I
D
S
-
A
Q
S
L
S
G
L
V
R
Y
Y
N
N
D
A
R
E
----
P
K
N
----
P
Q
--------
T
---
V
---
E
-----
A
----
S
----------------------------------
E
-
S
-----
S
N
--
P
--
M
V
------------------------
D
R
S
T
I
Q
R
D
A
Q
L
S
Y
K
L
A
P
Q
G
N
D
W
L
N
A
D
A
K
I
Y
W
S
E
V
R
I
N
A
Q
----------------------------------
E
Y
R
E
Q
I
--
T
K
G
A
R
L
E
N
R
--
S
T
L
FA
D
--
S
---
F
-
A
S
H
L
L
T
Y
--
G
G
E
Y
Y
R
Q
E
Q
G
S
H
----------------------------------------------------------------------------------------------------------------------
T
T
G
F
P
Q
A
K
I
D
F
S
S
G
W
L
Q
D
E
I
T
L
R
D
L
P
I
T
L
L
G
G
T
R
Y
D
S
Y
R
G
S
S
D
G
---------------------------------------------------------------------------------------------------------------------------------
Y
K
D
V
D
A
D
K
W
S
S
R
---------------
A
G
M
T
I
N
P
T
-
N
W
L
M
L
F
G
S
Y
A
Q
A
F
R
A
P
T
M
G
E
M
Y
N
D
S
K
HFSIGRF
Y
T
N
------
Y
W
V
P
N
P
-----
N
L
R
P
E
T
N
E
T
Q
E
Y
G
F
G
L
R
------
F
D
D
-
L
M
L
S
N
D
A
L
E
F
K
A
S
Y
F
D
T
K
A
K
D
Y
I
S
T
T
V
--
D
FAAA
T
-------------------
T
M
S
Y
N
V
P
N
A
K
I
W
G
W
D
V
M
T
K
Y
T
T
D
-------
L
F
S
L
D
V
A
Y
N
R
T
R
-
G
K
D
T
D
---------------------------------------------
T
G
-
E
Y
I
--
S
S
I
---
N
P
D
T
V
T
S
T
L
N
I
P
I
A
H
---
S
--
G
F
S
V
G
W
V
G
T
F
A
D
R
S
T
H
I
S
--------------------
S
---
K
Q
P
G
Y
G
V
N
D
F
Y
V
S
Y
Q
G
--
Q
Q
AL---
K
G
M
T
T
T
L
V
L
G
N
A
F
D
K
E
Y
W
S
P
---------------------
Q
G
I
P
Q
D
G
R
N
G
K
I
F
V
S
Y
Q
W
--
20
PsiBlast_PDB
44.24
23%
-150
- C2 -
-
2W6T
-
FPVA_PSEAE
A:
[5-73]
-------------------------------------------------
F
D
I
P
P
Q
A
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
43.72
23%
-154
- C2 -
-
2O5P
-
FPVA_PSEAE
A:
[5-73]
-------------------------------------------------
F
D
I
P
P
Q
A
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
43.64
14%
-
- C3 -
-
3V89
-
TBP1_NEIMB
A:
[51-915]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
N
E
----------------
V
T
G
L
G
K
L
V
K
S
--------
S
D
T
L
S
K
E
Q
V
-
L
N
I
R
D
L
T
R
Y
D
P
G
I
A
V
V
E
Q
G
--
R
----
G
----
A
S
S
G
Y
S
I
R
G
M
D
K
---
N
R
V
S
L
T
V
D
G
V
S
Q
I
Q
S
Y
T
A
Q
AALGG
T
R
T
A
--------
G
S
S
G
A
I
N
E
I
E
Y
E
N
V
K
A
V
E
I
S
K
G
S
N
S
V
E
Q
G
S
G
A
L
A
G
S
V
A
F
Q
T
K
T
A
D
D
V
I
G
E
-
G
R
Q
W
G
I
Q
S
K
T
A
Y
S
G
K
------------------------------------------
N
R
G
L
T
Q
S
I
A
L
A
G
R
I
---------
G
G
A
E
A
L
L
I
H
T
G
R
R
A
G
EIR
A
H
E
D
A
----
G
R
G
V
Q
S
-----------
F
N
R
L
V
P
V
E
D
S
--------
S
N
Y
A
-----------
Y
F
I
V
K
E
E
C
K
---
N
G
S
Y
E
T
C
K
A
N
P
K
K
D
V
V
G
K
D
E
R
Q
T
-
V
S
T
R
D
Y
T
G
P
N
R
F
L
--
A
D
--
P
L
S
Y
E
----
S
R
--------
S
---
W
---
L
-----
F
----
R
----------------------------------
P
-
G
-----
F
R
--
F
--
E
N
K
-----------------------
R
H
Y
I
G
G
I
L
E
H
T
Q
Q
T
F
D
T
R
D
M
T
V
P
A
F
L
T
K
A
V
F
D
A
N
K
K
Q
A
G
S
L
P
-
G
-
N
G
K
Y
---------
A
G
N
H
K
-
Y
G
G
-
L
--
F
T
N
G
E
N
G
A
--
L
V
G
A
E
Y
G
T
G
--
V
----
F
--
Y
---
D
-
E
T
H
T
K
S
R
--
Y
G
L
E
Y
V
Y
T
N
A
D
K
D
T
W
-
A
D
------------
Y
--
A
-------------------
R
------------------------
L
--------
S
-------------
Y
---
D
------------------
R
-----
Q
G
V
G
L
D
N
H
F
Q
Q
T
H
C
S
-
A
D
G
S
D
K
Y
C
-
R
P
S
A
D
K
P
F
---
S
Y
Y
K
S
D
R
V
I
Y
G
E
S
H
R
L
L
Q
A
A
F
K
K
S
F
D
R
H
N
L
S
V
N
L
G
F
D
R
F
G
S
N
L
R
H
Q
D
Y
Y
Y
Q
H
A
N
R
A
Y
S
S
N
T
P
P
Q
N
N
G
K
K
I
S
P
N
G
S
E
T
S
P
Y
W
V
T
I
G
R
G
N
V
V
T
G
Q
I
C
R
L
G
N
N
T
Y
T
D
C
----
T
P
R
S
I
N
G
K
S
Y
Y
A
A
V
R
D
N
V
R
L
G
R
W
A
D
V
G
A
G
L
R
Y
D
Y
R
S
T
H
S
D
DGSVSTGTHR
T
L
S
W
N
A
G
I
V
L
K
P
T
-
D
W
L
D
L
T
Y
R
T
S
T
G
F
R
L
P
S
F
A
E
M
Y
G
W
R
A
G---------------
V
Q
S
K
A
V
-----
K
I
D
P
E
K
S
F
N
K
E
A
G
I
V
F
K
GDF
G
N
L
E
A
S
-
W
F
N
N
A
Y
R
D
L
I
V
R
G
Y
E
A
Q
I
K
D
G
K
E
E
A
K
G
--
D
------------------------
P
A
Y
L
N
A
Q
S
A
R
I
T
G
I
N
I
L
G
K
I
D
W
N
-------
G
W
Y
S
T
F
A
Y
N
R
V
R
V
R
D
I
K
K
R
A
D
R
T
D
--------
I
Q
S
H
L
F
D
A
-----
I
Q
P
S
------
R
Y
V
V
G
L
G
Y
D
Q
P
E
G
K
W
G
V
N
G
---
M
L
T
Y
S
K
A
K
E
I
T
E
L
L
G
---
S
--
R
A
L
L
N
G
N
S
R
N
T
K
A
T
A
R
--
R
T
R
P
--
W
Y
--
I
V
D
V
--
S
G
Y
Y
T
V
K
K
H
F
T
L
R
A
G
V
Y
N
L
L
N
Y
R
Y
--
V
------
T
W
E
N
V
R
Q
T
A
G
G
A
V
N
Q
-
H
K
N
V
G
V
-----------------
Y
-
N
R
Y
A
A
P
G
R
N
Y
T
F
S
L
E
M
K
F
--
37
HHSearch
43.56
18%
39
- C3 -
-
3V8X
4
TBP1_NEIMB
A:
[43-904]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
T
G
L
G
K
L
V
K
S
S
D
T
L
S
K
E
Q
V
-
L
N
I
R
D
L
T
R
Y
D
P
G
I
A
V
V
E
Q
G
--
R
----
G
----
A
S
S
G
Y
S
I
R
G
M
D
K
---
N
R
V
S
L
T
V
D
G
V
S
Q
I
Q
S
Y
--------
T
A
Q
A
ALGG
T
R
T
A
G
S
S
G
A
I
N
E
I
E
Y
E
N
V
K
A
V
E
I
S
K
G
S
N
S
V
E
Q
G
S
G
A
L
A
G
S
V
A
F
Q
T
K
T
A
D
D
V
I
G
E
-
G
R
Q
W
G
I
Q
S
K
T
A
Y
S
G
K
N
R
G
------------------------------------------------
L
T
Q
S
I
A
L
A
G
R
---
I
G
G
A
E
A
L
L
I
H
T
G
R
R
A
G
---
E
I
R
A
H
EDAG
R
G
V
Q
S
F
N
R
L
V
P
V
E
D
SSN
Y
A
Y
F
I
V
K
E
E
C
KNGSYETC
K
A
N
P
K
K
D
V
V
G
K
D
E
R
Q
T
V
S
T
R
D
Y
T
G
PNR
F
L
A
D
P
L
S
Y
E
S
R
S
W
L
F
R
P
G
F
R
F
E
N
K
R
H
Y
I
G
G
I
L
E
H
T
Q
Q
T
F
D
T
--
R
D
M
T
V
----
P
A
--------
F
---
L
---
T
K
A
V
F
D
A
----
N
K
K
Q
AGSLPGNGKYAGNHKYGG
L
F
T
N
G
E
NG
A
L
V
G
A
E
-
Y
-----
G
T
--
G
--
V
F
Y
-----------------------
D
E
T
H
T
K
S
R
Y
G
L
E
Y
V
Y
T
N
A
D
K
D
T
W
A
D
Y
A
R
L
S
Y
D
R
Q
G
V
G
L
D
N
H
F
-
Q
Q
T
H
C
S
ADGSDKY
C
R
P
S
A
D
K
-
P
F
S
Y
Y
K
S
D
R
V
I
Y
G
E
S
--
H
R
L
L
Q
A
A
F
K
--
K
----
S
--
F
D---K
I
R
H
N
L
S
V
N
L
G
F
D
R
F
G
S
N
L
R
H
Q
D
Y
Y
Y
Q
H
------------
A
--
N
-------------------
R
A
Y
S
S
N
T
P
P
QNNG
K
K
I
S
P
NGSET
S
P
Y
--------
W
-------------
V
T
--
I
G
R
G
N
V
V
T
G
Q
ICRLGNNTY
T
-----
D
C
T
P
R
S
I
N
G
K
S
Y
Y
A
A
V
R
D
N
V
R
L
G
R
-
W
A
D
V
G
A
G
L
R
Y
D
Y
R
S
T
H
S
D
D
G
-------------------------------------------------------------------------------------------------------------------------------
S
V
S
T
G
T
H
R
T
L
S
W
N
---------------
A
G
I
V
L
K
P
T
-
D
W
L
D
L
T
Y
R
T
S
T
G
F
R
L
P
S
F
A
E
M
Y
G
W
R
A
G---------------
V
Q
S
K
A
V
-----
K
I
D
P
E
K
S
F
N
K
E
A
G
I
V
F
K
------
G
D
--------
F
G
N
L
E
A
S
W
F
N
N
A
Y
R
D
L
I
V
R
G
Y
--
E
A
Q
I
K
DG
K
E
E
A
K
G
D-----------
P
A
Y
L
N
A
Q
S
A
R
I
T
G
I
N
I
L
G
K
I
D
W
N
GVW------
Y
S
T
F
A
Y
N
R
V
R
-
V
R
D
I
K
K
R
-
A
--------------------------
D
--------
R
--
T
D
I
Q
S
-
H
L
F
--
D
A
I
---
Q
P
S
R
Y
V
V
G
L
G
Y
D
Q
P
E
---
G
--
K
W
G
V
N
G
M
L
T
Y
S
K
A
K
E
I
T
E
L
L
G
S
R
A
L
L
--
N
G
N
S
--
R
N
T
K
A
T
A
R
R
T
R
P
W
Y
I
V
D
V
S
G
Y
Y
T
V
--
K
------
K
H
F
T
L
R
A
G
V
Y
N
L
L
N
Y
R
Y
V
T
W
E
N
VRQTAGGAVNQHKNVGV
Y
-
N
R
Y
A
A
P
G
R
N
Y
T
F
S
L
E
Y
K
F
--
34
HHSearch
43.51
19%
33
- C3 -
-
1KMO
17
FECA_ECOLI
A:
[114-774]
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
T
V
V
G
D
W
L
G
D
-----------------
A
R
E
N
D
V
F
E
H
A
G
A
R
D
V
I
R
R
E
D
F
A
K
T
G
A
-
T
T
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
--
G
----
T
GSHD
L
A
M
N
F
G
I
R
G
L
N
P
R
LA
S
R
S
T
V
L
M
D
G
I
P
V
P
F
A
P
--------
Y
G
Q
P
----------
Q
L
S
L
A
P
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
P
Q
S
V
G
G
V
V
N
F
V
T
R
A
I
P
Q
-------
D
F
G
I
E
A
G
V
E
G
Q
L
S
P
T
S
---------
S
Q
N
---------------------------
N
------
P
K
E
T
H
N
L
M
V
G
G
T
A
--
D
N
G
F
G
T
A
L
L
Y
S
G
T
R
G
S
---
D
W
R
E
-----------------------------------------------------------------------
H
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
-
V
H
T
F
N
S
L
L
Q
Y
Y
D
G
E
A
D
M
--
P
G
G
L
S
----
R
A
--------
D
---
Y
---
D
-----
A
----
D
R---------------------------------
W
-
Q
-----
S
T
--
R
--
P
Y
D
-----------------------
R
F
W
G
R
R
K
L
A
S
L
G
Y
Q
F
Q
P
D
S
--
Q
H
K
F
N
I
Q
G
F
Y
T
Q
T
L
R
S
G
Y
L
E
Q
-
G
-
K
R
-------------------
I
--
T
--
L
S
P
R
N
Y
W
--
V
R
G
I
E
P
R
Y
S
Q
I
F
----
M
--
I
---
G
P
S
A
H
E
V
G
V
--
G
Y
R
Y
L
N
E
S
T
H
E
M
R
Y
Y
-
T
A
------------
T
--
S
-------------------
S
GQL---------------------
P
--------
S
-------------
G
---
S
S-----------------
P
-----
Y
D
R
D
T
R
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
I
G
--
N
W
T
I
T
P
G
M
R
F
E
H
I
E
S
Y
Q
N
N
A
I
----------------------------------------------------------------------------------------------------------------------------
T
G
T
H
E
E
V
S
Y
N
A
P
L
P
A
---------------
L
N
V
L
Y
H
L
T
-
D
S
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
I
G
K
A
--------------------
V
Q
S
G
-----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
------
D
--------
G
A
L
T
A
E
M
G
L
F
L
I
N
F
N
N
Q
Y
D
S
N
Q
--
T
N-----------------------
D
T
V
T
A
R
G
K
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
TLTPTLD
N
V
S
I
Y
A
S
Y
A
Y
V
N
-
A
E
I
R
E
K
G
-----------------------------------------
D
T
Y
G
-
N
L
V
--
P
F
S
---
P
K
H
K
G
T
L
G
V
D
Y
K
P
G
-------
N
W
T
F
N
L
N
S
D
F
Q
S
S
Q
F
A
D
N
A
N
T
V
--
K
---------
E
S
A
D
G
S
T
G
R
I
P
G
F
M
L
W
G
A
R
V
A
Y
D
F
--
G
PQM---
A
D
L
N
L
A
F
G
V
K
N
I
F
D
Q
D
Y
F
I
R
S
Y
DDNN-------------
K
-
G
I
Y
A
G
Q
P
R
T
L
Y
M
Q
G
S
L
K
F
--
19
PsiBlast_PDB
43.17
23%
-148
- C2 -
-
2W16
-
FPVA_PSEAE
A:
[5-73]
-------------------------------------------------
F
D
I
P
P
Q
A
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
R
G
T
G
A
S
V
D
F
Q
G
N
A
I
T
I
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
43.10
17%
53
- C3 -
-
5FP1
8
?
A:
[18-718]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
E
E
S
LKVDQSAN--------
S
K
F
V
A
P
L
L
D
T
P
K
S
V
S
V
I
S
K
Q
L
I
E
D
T
K
V
-
T
T
L
A
D
A
L
R
T
V
P
G
I
T
L
G
A
G
E
GG
N
----
P
----
N
G
D
R
P
F
I
R
G
Y
S
S
----
E
S
S
M
Y
I
D
G
I
R
N
S
T
S
---------------------------
Q
N
R
E
M
F
A
V
E
Q
V
E
V
T
K
G
S
A
S
A
M
G
G
A
G
S
V
G
G
S
I
N
M
I
S
K
V
A
K
K
-------
G
D
F
L
E
G
S
V
A
A
G
T
D
N
Y
Q
-------------------------------------------------
R
I
T
L
D
G
N
K
D
F--
G
N
G
I
A
A
R
V
A
V
L
G
H
Q
N
E
-----
K
A
G
-------------------------------------------------------------------
Q
S
N
G
A
E
Y
K
R
V
G
I
A
P
S
I
T
F
G
L
D
T
-
P
T
R
A
T
L
S
Y
Y
Y
L
Q
T
D
D
K
P
D
S
G
I
P
Y
W
----
D
S
SLGKAQGK
P
---
A
---
E
-----
V
----
K
QGT-------------------------------
Y
-
Y
-----
G
W
--
K
--
D
R
D
-----------------------
F
Q
K
Q
E
N
H
I
G
T
I
K
L
E
H
D
L
T
D
--
N
I
T
I
T
N
T
A
M
Y
A
K
S
K
N
D
Y
V
W
T
N
P
D
-
D
S
K
G
---------
N
V
G
K
G
-
L
V
W
-
H
R
L
N
S
A
I
T
D
S
E
--
T
F
T
D
Q
L
A
L
T
--
G
----
K
--
F
D
TG
F
-
L
K
H
R
F
N
V
--
G
A
E
Y
S
K
Q
K
T
D
K
G
G
Y
N
-
I
I
------------
D
AK
G
NVSSTGFYSDCSDLSTNWC
T
------------------------
S
LN------
G
-------------
P
T
Q
K
P
------------------
F
V
D
R
L
Q
A
R
P
D
F
D
A
T
V
E
S
T
S
V
Y
L
L
D
N
I
E
I
T
P
-
K
W
L
L
D
L
G
L
R
W
D
K
F
E
A
E
Q
N
F
L
A
T
S
------------------------------------------------------------------------------------------------------------------------
S
A
A
A
Y
T
A
K
N
N
S
D
F
V
T
Y
Q
---------------
A
G
I
T
F
K
P
T
-
E
N
G
S
I
Y
T
S
Y
A
T
S
A
S
P
V
G
L
N
A
G
W
G
D
N
S
ET--------------
I
N
A
N
N
Q
-----
M
I
D
P
E
E
A
Q
T
F
E
I
G
T
K
W
D
------
F
L
D
------
N
H
L
N
L
T
A
A
I
F
R
T
E
K
Q
N
T
R
V
Q
I
D
--
P
------------------------
T
T
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A
N
V
G
E
S
K
V
D
G
F
E
L
G
L
N
G
E
I
T
D------
K
W
N
I
S
A
G
Y
T
Y
L
D
-
S
E
L
T
K
N
G
K
S
C
R
------------
S
G
K
C
-----
T
--
D
------
Q
----
S
I
Y
N
G
-
N
Q
M
--
P
N
V
---
P
K
Q
A
A
T
L
W
T
T
Y
K
V
L
----
P
--
Q
L
T
V
G
A
G
A
V
Y
S
D
K
V
Y
G
D
V
--------------------
A
N
T
K
W
V
P
S
Y
V
R
Y
D
A
M
A
R
Y
N
V
--
N
------
K
N
V
D
L
Q
L
N
I
N
N
L
S
D
K
R
Y
F
T
K
A
Y
AS---------------
H
-
Y
A
T
E
A
E
G
R
S
A
V
L
A
V
N
F
K
Y
--
36
HHSearch
42.36
16%
37
- C3 -
-
4RDR
5
Y964_NEIMB
A:
[32-748]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
P
R
----------------
A
-
T
S
G
L
L
H
T
S
T
A
S
D
K
I
I
S
G
D
T
L
R
Q
-
K
A
-
V
N
L
G
D
A
L
D
G
V
P
G
I
H
A
S
Q
Y
G
--
G
---------
G
A
S
A
P
V
I
R
G
Q
T
G
---
R
R
I
K
V
L
N
H
H
G
E
T
G
D
M
A
--------
D
F
S
-----------
P
D
H
A
I
M
V
D
T
A
L
S
Q
Q
V
E
I
L
R
G
P
V
T
L
L
Y
S
S
G
N
V
A
G
L
V
D
V
A
D
G
K
I
P
E
K
M
-
P
-
E
N
G
V
S
G
E
L
G
L
R
L
S
S
G
N
L
E
------------------------------------------------
K
L
T
S
G
G
I
N
I
G
L--
G
K
N
F
V
L
H
T
E
G
L
Y
R
K
S
G
---
D
Y
A
V
P
----
R
Y
R
------------------------------------------------------
N
L
---
K
R
L
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S
H
A
D
S
Q
T
G
S
I
G
L
S
W
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G
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G
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S
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R
R
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P
A
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H
----
E
Y
--------
D
---
D
CHA
D
-----
I
IW
Q
K
S
L
I
--------------------------------
N
K
R
-----
Y
L
--
Q
--
L
Y
P
HLLTEEDIDYD
N
P
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L
S
C
GHS
G
R
P
W
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R
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--
A
-
G
-------------------------
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Q
N
A
R
I
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L
R
--
H
----
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---
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L
K
G
S
W
--
G
V
Q
Y
L
Q
Q
K
S
S
A
L
S
A
I
-
S
E
------------
A
--
V
------------------------------------------------------------------------------------------
K
-----
Q
P
M
L
L
D
N
K
V
Q
H
Y
S
F
F
G
V
E
Q
A
N
W
-
D
-
N
F
T
L
E
G
G
V
R
V
E
K
Q
K
A
S
I
Q
Y
D
K
A
L
I
------------------------------------------------------
D
R
-------
E
---
N
----------------------------------------
Y
----
Y
----
N
H
P
L
P
D
L
G
A
H
R
Q
T
A
R
S
F
A
---------------
L
S
G
N
W
Y
F
T
-
P
Q
H
K
L
S
L
T
A
S
H
Q
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R
L
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S
T
Q
E
L
Y
A
H
G
K
H
VATN
T
----------
F
E
V
G
N
K
-----
H
L
N
K
E
R
S
N
N
I
E
L
A
L
G
Y
E
------
G
--------
D
R
W
Q
Y
N
L
A
L
Y
R
N
R
F
G
N
Y
I
Y
A
Q
T
--
L
NDGRGPKSIEDDSEMK--------
L
V
R
Y
N
Q
S
G
A
D
F
Y
G
A
E
G
E
I
Y
F
K
P
T
P------
R
Y
R
I
G
V
S
G
D
Y
V
R
-
G
R
L
K
N
L
P
S
L
P
--------
G
R
E
D
A
Y
G
----------
N
------
R
P
F
--
I
A
Q
D
D
-
Q
N
A
--
P
R
V
---
P
A
A
R
L
G
F
H
L
K
A
S
L
T
----
D
--
R
I
D
A
N
L
D
Y
Y
R
V
F
A
Q
N
K
L
A
--------------------
R
Y
E
T
R
T
P
G
H
H
M
L
N
L
G
A
N
Y
R
R
--
N
T
R
Y---
G
E
W
N
W
Y
V
K
A
D
N
L
L
N
Q
S
V
Y
A
H
S
S
F----------------
L
-
S
D
T
P
Q
M
G
R
S
F
T
G
G
V
N
V
K
F
--
48
HHSearch
42.07
17%
40
- C3 -
-
3QLB
2
?
B:
[73-748]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
S
AT
G
P
Q
A
G
YVAKRSLSG
T
K
T
D
A
S
L
S
E
I
P
Q
S
I
S
V
I
T
R
D
Q
M
D
A
Q
Q
V
-
Q
S
V
N
E
A
L
R
Y
T
A
G
V
Q
A
N
T
T
A
--
A
S---
Q
----
R
F
D
T
L
S
I
R
G
F
D
V
---
T
-
T
G
M
L
R
D
G
L
K
G
N
T
A
Q
------------------------
A
W
P
K
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
Q
N
S
P
G
G
V
V
N
Q
I
S
K
R
P
L
D
-------
K
P
F
H
E
V
Q
I
Q
G
G
S
F
D
R
A
-----------------------------------------------
Q
G
Q
F
D
F
S
G
P
L
D
D--
E
G
Q
F
L
Y
R
L
V
G
L
E
R
D
S
G
---
T
Q
F
D
-----------------------------------------------------------------------
H
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
N
D
-
D
T
S
L
T
L
L
A
D
Y
T
Q
D
T
F
G
A
--
P
R
V
F
L
----
P
A
--------
Q
GTL
L
---
G
-----
N
----
P
----------------------------------
N
-
G
KVRHN
V
F
--
L
DE
P
G
L
-----------------------
D
N
D
R
T
Q
Y
S
L
G
Y
L
L
E
H
R
L
N
D
--
V
W
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L
N
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S
A
R
Y
G
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V
N
L
L
T
N
T
A
S
-
G
-
M
S
L
A
---------
P
D
L
R
T
L
N
R
A
-
A
Y
R
F
R
I
V
G
D
T
Y
--
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L
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N
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A
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--
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----
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--
L
---
G
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T
Q
M
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S
L
L
--
G
I
D
Y
R
R
T
R
E
D
Y
Y
L
R
G
-
G
S
------------
A
--
S
-------------------
P
I
D
IY
N
-------------------
P
V
H
HVF---
D
-------------
P
---
S
------------------
T
-----
P
F
T
N
T
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
W
V
L
T
V
G
G
R
Q
D
R
S
S
A
R
T
D
N
R
M
----------------------------------------------------------------------------------------------------------------------------
N
D
S
G
S
K
Q
D
D
E
K
F
T
Y
R
---------------
T
G
L
V
Y
L
A
D
-
N
G
L
A
P
Y
I
S
Y
S
T
S
F
D
P
V
L
G
T
N
F
------------------------
Y
G
T
-----
P
Y
K
P
T
S
A
K
Q
S
E
V
G
V
K
Y
Q
------
P
P
G
------
I
D
S
Y
I
T
L
S
L
F
D
L
T
Q
E
N
V
L
T
T
D
P
AQ
R
------------------------
L
N
K
I
Q
T
G
E
I
N
V
R
G
I
E
L
E
G
K
A
S
L
A
R------
G
L
D
L
L
A
A
L
T
Y
N
D
-
A
E
V
S
K
S
N
----------------------------
N
------
P
-----
L
E
K
G
-
K
R
P
--
T
D
T
---
P
E
K
M
A
S
L
W
A
D
Y
T
L
P
E
GPL
S
--
G
L
G
F
G
A
G
V
R
Y
I
G
S
T
E
A
D
A
A
--------------------
N
T
Q
R
V
P
S
Y
T
L
L
D
A
A
V
H
Y
D
F
--
D
KLIPAA
K
G
L
R
L
A
V
N
A
T
N
L
T
D
K
H
Y
Y
E
G
C
S
-----------------
L
T
N
C
S
A
G
Y
D
R
S
V
I
A
S
L
R
Y
R
W
--
49
HHSearch
41.69
17%
38
- C3 -
-
3QLB
2
?
A:
[73-748]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
S
AT
G
P
Q
A
G
YVAKRSLSG
T
K
T
D
A
S
L
S
E
I
P
Q
S
I
S
V
I
T
R
D
Q
M
D
A
Q
Q
V
-
Q
S
V
N
E
A
L
R
Y
T
A
G
V
Q
A
N
T
T
A
--
A
S---
Q
----
R
F
D
T
L
S
I
R
G
F
D
V
---
T
-
T
G
M
L
R
D
G
L
K
G
N
T
A
Q
------------------------
A
W
P
K
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
Q
N
S
P
G
G
V
V
N
Q
I
S
K
R
P
L
D
-------
K
P
F
H
E
V
Q
I
Q
G
G
S
F
D
R
A
-----------------------------------------------
Q
G
Q
F
D
F
S
G
P
L
D
D--
E
G
Q
F
L
Y
R
L
V
G
L
E
R
D
S
G
---
T
Q
F
D
-----------------------------------------------------------------------
H
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
N
D
-
D
T
S
L
T
L
L
A
D
Y
T
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D
T
F
G
A
--
P
R
V
F
L
----
P
A
--------
Q
GTL
L
---
G
-----
N
----
P
----------------------------------
N
-
G
KVRHN
V
F
--
L
DE
P
G
L
-----------------------
D
N
D
R
T
Q
Y
S
L
G
Y
L
L
E
H
R
L
N
D
--
V
W
S
L
N
S
S
A
R
Y
G
H
V
N
L
L
T
N
T
A
S
-
G
-
M
S
L
A
---------
P
D
L
R
T
L
N
R
A
-
A
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R
F
R
I
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D
T
Y
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L
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N
N
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A
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--
W
----
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--
L
---
G
S
T
Q
M
V
S
L
L
--
G
I
D
Y
R
R
T
R
E
D
Y
Y
L
R
G
-
G
S
------------
A
--
S
-------------------
P
IDIY
N
-------------------
P
V
H
H
H
HGVF
D
-------------
P
---
S
------------------
T
-----
P
F
T
N
T
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
W
V
L
T
V
G
G
R
Q
D
R
S
S
A
R
T
D
N
R
M
----------------------------------------------------------------------------------------------------------------------------
N
D
S
G
S
K
Q
D
D
E
K
F
T
Y
R
---------------
T
G
L
V
Y
L
A
D
-
N
G
L
A
P
Y
I
S
Y
S
T
S
F
D
P
V
L
G
T
N
F
------------------------
Y
G
T
-----
P
Y
K
P
T
S
A
K
Q
S
E
V
G
V
K
Y
Q
------
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P
G
------
I
D
S
Y
I
T
L
S
L
F
D
L
T
Q
E
N
V
L
T
T
D
P
AQ
R
------------------------
L
N
K
I
Q
T
G
E
I
N
V
R
G
I
E
L
E
G
K
A
S
L
A
R------
G
L
D
L
L
A
A
L
T
Y
N
D
-
A
E
V
S
K
S
N
----------------------------
N
------
P
-----
L
E
K
G
-
K
R
P
--
T
D
T
---
P
E
K
M
A
S
L
W
A
D
Y
T
L
P
E
GPL
S
--
G
L
G
F
G
A
G
V
R
Y
I
G
S
T
E
A
D
A
A
--------------------
N
T
Q
R
V
P
S
Y
T
L
L
D
A
A
V
H
Y
D
F
--
D
KLIPAA
K
G
L
R
L
A
V
N
A
T
N
L
T
D
K
H
Y
Y
E
G
C
S
-----------------
L
T
N
C
S
A
G
Y
D
R
S
V
I
A
S
L
R
Y
R
W
--
46
HHSearch
40.26
15%
53
- C3 -
-
5FR8
1
?
B:
[27-733]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
V
T
A
E
E
Q
-------------------------
V
K
Q
S
L
G
V
S
V
I
T
K
E
D
L
E
K
L
P
V
R
N
D
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S
D
Y
V
R
R
M
P
G
V
N
L
T
G
N
S
--
A
TGQR
G
----
N
N
R
Q
I
D
I
R
G
M
G
P
---
E
N
T
L
I
L
V
D
G
K
P
I
N
S
R
N
--------
S
V
R
Y
GWKGER--
D
T
R
G
D
S
N
W
V
P
A
E
A
I
E
S
I
E
V
L
R
G
P
A
A
A
R
Y
G
S
G
A
A
G
G
V
V
N
I
I
T
K
K
V
T
N
-------
E
T
H
G
S
V
E
F
Y
T
S
Q
P
E
D
S
-------
K
E
G
S
------------------------------------
S
N
R
V
G
F
N
V
S
G
P
LI-
K
D
V
L
S
Y
R
L
Y
G
N
Y
N
K
T
E
---
A
D
D
V
D
----
I
N
K
--------------------
S
--
I
------------------------------
G
S
---
T
A
A
G
R
E
G
V
K
N
K
D
I
S
G
R
L
A
W
Q
A
T
D
-
Q
Q
T
V
L
L
D
I
S
S
S
K
Q
G
N
I
Y
--
S
G
D
S
Q
----
L
N
--------
A
---
N
---
A
-----
E
----
A
----------------------------------
D
-
A
-----
I
L
--
S
Q-
L
I
G
KE---------------------
T
N
T
M
Y
R
D
S
Y
A
L
T
H
E
G
D
W
---
S
W
G
K
S
K
L
V
A
Q
Y
D
K
T
H
N
K
R
L
P
E
G
-
L
-
A
G
S
V
---------
E
G
K
----
I
N
-
N
L
D
D
K
A
T
S
R
L
E
TL
R
F
N
G
E
A
N
I
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--
F
----
E
--
Y
---
Y
-
L
P
Q
V
L
T
V
--
G
T
E
W
V
E
D
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F
K
D
N
V
S
T
-
T
Q
------------
G
K-
D
SSG----------------
S
------------------------
G
--------
Y
-------------
G
---
D
QL----------------
A
-----
K
G
D
R
S
K
M
E
S
R
I
A
S
A
Y
I
E
D
N
L
K
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T
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-
S
T
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V
V
L
G
L
R
F
D
D
H
S
K
-----------------------------------------------------------------------------------------------------------------------------------------
S
G
S
N
W
S
P
S
---------------
L
N
I
T
Q
K
L
N
-
D
Y
F
T
L
K
G
G
V
A
K
A
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K
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M
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Q
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A
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L
LSTNGNGCPANIESRC
L
L
Q
G
N
G
-----
D
L
K
P
E
T
S
V
N
K
E
L
G
I
Q
F
Q
------
K
D
--------
I
V
N
A
S
L
T
W
F
R
N
D
Y
K
D
K
I
V
A
G
T
--
H
VVGTVDGSSTNANTGAVTNTKWNI
L
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W
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N
T
P
K
A
L
I
Q
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F
E
G
S
L
G
L
D
F
G
-------
D
I
R
W
T
N
N
F
T
Y
M
M
D
-
S
K
D
K
--------------------------------------------
Q
T
G
-
N
P
L
--
S
L
V
---
P
I
Y
T
I
N
S
I
F
D
Y
D
I
T
----
D
--
Q
L
D
V
N
F
V
F
T
Q
Y
G
R
Q
K
S
R
Q
F
A
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N
--
R
L
ES
G
I
G
S
GG
A
N
S
A
L
K
P
S
T
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K
S
Y
S
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A
G
I
N
V
G
Y
K
F
--
S
------
D
Q
I
S
T
R
V
G
V
S
N
L
F
D
K
Q
I
L
R
D
S
N
SI---------------
S
-
Q
T
Y
N
E
P
G
R
A
Y
Y
A
S
L
K
Y
S
F
--
23
Fugue
40.19
21%
-105
* C2 *
-
2A02
-
PUPA_PSEPU
A:
[1-82]
--------------------------------------------
S
Q
E
W
T
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D
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A
Q
S
M
N
S
A
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N
T
V
T
V
T
A
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A
A
A
K
D
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------