@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRV5: (2017-12-04 )
MSLLRLDRLHYCILMSMGCISSPLVWAEDLNSDVAKLPTLHVEATRTDTGYLQTPASVFRIEAPQVDSSSQVNLTEVVKGIPSLQIRNRENYAQDLQLSMRGFGARSTFGVRGIRLYVDGIPATMPDGQGQTSNIDLSSLDHVEVLTGPFSSLYGNSSGGTILTSTKEGQGKDSIELSYSGGSHDKSRAGLVLQGGAKGANEPSYIISSSYFDTDGYREHSGAEKVLNNAKLSWNLDDGSKINWVTNYVKINADDPGGLTRADWQNNPKQVVQNVLDYNARKEIEQTQTGLTWSKPINDQHELYAMTYMGQRQVTQYQSIPDTVQKNPNTPYQAGGVIDFKRNYYGADFRWTGKELLPNTTLSIGVALDAMKEDRQGYQNFNDTGDKGVKGALRRDEDNTLWNIDPYVQASWQFLPTWRLDTGVRYSNVHYKSKDYYIVGLNGDNSGKTSYEEVLPSVALSWQITPEVLAYASYAKGFETPTFTEMAYPAQGGASTLDLKPSTSDTYETGLKSQNQLGDFTLAVFQTKTKNDIVSAESFGGRSTFRNADKTLREGVEFAWNKKLWRDLIAIASYTYLDATFDSTVPAAGKISEIPEGNAIPGIAKNQAYVSLAWQPSHGLYGGVDVQYMDKVYVNDTNSDAAPSYSVTSANVGYAWVMGDWKVNSFARVDNLFDRNYAGSVIVNDSTQPVGRYFEPADGRNWSAGLRVIKQF
Atome Classification :
(20 SA)
-------------.......-----..10........20........30......------------..40-..------------------.------------.-------------.---------------------..----.50........60.......-.70........80.....-...90-...---.---....100.......110...--------....120...-.---..-.--130-..--.-----.....140.......150...-.-..-.160.......170.------...------...180-----.-----...--.----..190.......200.......210..--.------....---220.......230.......240.......250.-..---.-..---.260.------..-----....-270-..-....---.---.---.280.......290.....--..300.......310.......--320----------------.-----.-.-..------.-.-.---330---.--.---.-.-....340..--.--....350...--.-...-360.......370.......380----------.-.--.---------.---------------------.-----------------------.----.----.-----.-------390.---.------..---------------.....400.......410....-...420.......430.......440--........450.......460.......470.......480....---...490---------.--.....-..500.......510..--.------.-..--.520..---.....530......---.------540----...---......550.......560...------.-----...570........580.......----590....-----...600.......610.....---.----.620----.......630.-------....---------..640---------.......650.....-.---.660..----.....670.......680.......690.......700.......710
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------MS
L
L
R
L
D
-----
R
L
H
Y
C
I
L
M
S
M
GCISSP
L
V
W
A
E
D
LN
S
D
V
A
KL------------
P
T
L
H
-
V
E
------------------
A
------------T-------------R---------------------TD----TGYLQTP
A
S
V
F
R
I
EAPQVDS-SSQV
N
L
T
E
V
VKGIPS
L
Q
I
-R
N
R
E
N
-
Y
A
Q
---
D
---
L
Q
L
S
M
R
GFGARSTFGV
R
G
I
R
--------
L
Y
VDGIPATM-P---DG-Q--GQ--TS--N-----IDLSSLD
H
V
E
V
LTG
P
F
S
S
LYG-N-SS-G
G
T
I
L
T
STKEGQGK
D
------
S
I
E
------
L
S
YSGG-----S-----HDK--S----RA
G
L
V
L
QGGAKGANEP
S
Y
I
I
S
S
S
YFDT--D------GYRE---HS
G
A
E
K
V
L
NNA
K
L
S
W
NLDDG
S
K
I
N
W
V
T
N
Y
V
K
I
NA-DD---P-GG---LT
R
A
D
------WQ-----N
N
P
K
-
Q
---
V
V
-
Q
N
V
L
---
D
---
Y
---
N
A
R
K
E
I
E
Q
T
QTGLTWSKPI--ND
Q
H
E
L
Y
A
M
T
YMGQ
R
Q
V
T
Q
Y
QS--I
P
-----------------
D
-----
T
-
V
-QK------N-P-N---TP----Y--Q---A-G-
G
V
I
D
FKRNY--Y--GAD
F
R
WTGKE--L-LPN-T
T
L
S
I
G
V
A
L
D
A
M
K
E
D
R
Q
GYQN------------F-N--D---------T---------------------G-----------------------D----K----
G
-----
V
-------
K
--G---A------LR---------------RDEDNTLWNIDP
Y
V
Q
A
S
W
Q
F
L
P
-
T
W
RLDTG
V
R
Y
S
N
V
H
Y
KSK
D
Y
Y
I
V
G
L---NGDNSGKT
S
Y
E
E
V
L
P
S
V
A
L
S
W
QI
T
P
E
V
L
A
Y
A
S
Y
AKGFETPTFTEM---AYPAQ----------G--GA
S
T
L
-DLKPSTS
D
T
Y
E
TGLKSQ--N------Q-LG--
D
F
T
L
A
V
---
F
QTKTKNDIVSAES---F------G------GRS---TF
R
N
A
D
K
T
L
R
E
G
V
E
F
A
W
N
K
K
L
W
------
R
-----
D
L
I
A
I
-
A
S
Y
T
Y
L
DATFDSTVPAAG----KISEIPE-----GNAIPGIAKN
Q
A
Y
V
S
L
A
WQPS---H----GLYG----GV
D
V
Q
Y
M
D
K
V
Y
-------
V
NDT---------NSDAA---------PS
Y
S
VTSANV
G
Y
A
W
V
-
M
---GD
W
K
V
N
----
S
F
A
R
V
D
N
L
FDRNYA
G
S
V
I
VNDSTQPVGRYFEPADGR
N
W
S
A
G
L
R
V
I
KQF
30
HHSearch
60.18
16%
35
- C4 -
-
1XKW
7
FPTA_PSEAE
A:
[3-665]
--------------------------------------------------
T
S
A
T
Q
------------
P
P
G
V
-
T
T
------------------
L
------------
G
-------------
K
---------------------
V
P
----
L
K
P
R
E
L
P
Q
S
A
S
V
I
D
H
E
R
L
E
Q
-
Q
N
L
F
S
L
D
E
A
M
Q
Q
A
T
G
V
T
V
-
Q
P
F
Q
L
---
L
---
T
---
T
A
Y
Y
V
R
G
F
K
V
--------
D
S
--------
F
E
L
D
G
V
P
A
L
L
-
G
---
N
-----
T
A
--
S
S
--
P
-----
Q
D
M
A
I
Y
E
R
V
E
I
L
R
G
S
N
G
L
L
H
G
T
G
-
N
P
-
A
A
T
V
N
L
V
R
K
R
P
Q
R
E
F
------
A
A
S
------
T
T
L
S
A
G
-----
R
-----
W
D
R
--
Y
----
R
A
E
V
D
V
G
G
P
L
S
A
S
G
N
V
R
G
R
A
V
A
A
Y
E
D
R
--
D
------
Y
F
Y
D
---
V
A
D
Q
G
T
R
L
L
Y
G
V
T
E
F
D
L
S
P
D
T
L
L
T
V
G
A
Q
Y
Q
H
I
D
S
-
I
T
---
N
M
A
G
---
V
P
M
A
K
------
D
G
-----
S
N
L
G
-
L
---
S
R
-
D
T
Y
L
D--
V
---
D
---
W
D
R
F
K
W
D
T
Y
R
A
F
G
S
L
E
Q
Q
L
--
G
G
G
W
K
G
K
V
S
A
E
Y
Q
E
A
D
S
R
L
R
Y
A
--
G
S
-----------------
F
-----
G
A
I
-
D
P
------
Q
T
G
-
D
---
G
G
----
Q
--
L
---
M
-
G
-
A
A
Y
K
F
K
S
I
Q
--
R
--
S
L
D
A
N
L
N
G
P
V
--
R
L
F
G
L
T
H
E
L
L
G
G
V
T
Y
A
Q
G
E
T
R
Q
D
T
A
R
F
------------
L
-
N
--
L
---------
P
N
T
-------------------
P
-----------------------
V
N
VYR
W
----
D
-----
P
HGV
P
R
P
Q
I
--
G
---
Q
------
Y
T
---------------
S
P
G
T
T
T
T
T
Q
K
G
L
Y
A
L
G
R
I
K
L
A
E
-
P
L
T
L
V
V
G
G
R
E
S
W
W
D
Q
D
T
P
A
T
-------------
R
F
K
P
G
R
Q
F
T
P
Y
G
G
L
I
W
D
F
A
R
D
W
S
W
Y
V
S
Y
A
E
V
Y
Q
P
---------------------------------
P
L
S
P
V
E
G
K
T
Y
E
T
G
I
K
G
E
L
-
A
D-----
G
-
R
L
--
N
L
S
L
A
A
---
F
R
I
D
L
E
N
N
P
Q
E
D
P
D
---
H
------
P
GPP---
N
N
P
---
F
Y
I
S
G
G
K
V
R
S
Q
G
F
E
L
E
G
T
G
Y
L
T
------
P
-----
Y
W
S
L
S
-
A
G
Y
T
Y
T
S
T
E
Y
L
K
D
S
Q
----------
N
D
S
G
-----
T
R
Y
S
T
F
T
P
R
H
L
L
R
L
W
S
N
Y
D
L
P
WQD
R
----
R
W
S
V
----
G
G
G
L
Q
A
Q
S
D
Y
S
-------
V
D
Y
R
G--------
V
S
M
R
Q
---------
G
G
Y
A
L
V
N
M
R
L
G
Y
K
I
D
-------
E
H
W
T
----
A
A
V
N
V
N
N
L
F
D
R
T
Y
Y
Q
S
L
S
N
P
------
N
W
N
N
R
Y
G
E
P
R
S
F
N
V
S
L
R
G
A
F
--
32
HHSearch
59.95
20%
56
- C4 -
-
5FP1
8
?
A:
[18-718]
---------------------------------------------------------------------------------------------------------
T
QEESLKVDQSANS
K
---------------------
F
V
----
A
P
L
L
D
T
P
K
S
V
S
V
I
S
K
Q
L
I
E
D
-
T
K
V
T
T
L
A
D
A
L
R
T
V
P
G
I
T
L
-
G
A
G
E
G
G
N
P
N
---
G
---
D
R
P
F
I
R
G
Y
S
S
-------
E
S
S
--------
M
Y
I
D
G
I
R
N
S
T
-
S
--------------
Q
--
N
-----
R
E
M
F
A
V
E
Q
V
E
V
T
K
G
S
A
S
A
M
G
G
A
G
-
S
V
-
G
G
S
I
N
M
I
S
K
V
A
K
K
G
D
------
F
L
E
------
G
S
V
A
A
G
-----
T
-----
D
N
Y
--
Q
----
R
I
T
L
D
G
N
K
D
F
--
G
N
G
I
A
A
R
V
A
V
L
G
H
Q
N
E
K
A
------
G
Q
S
N
---
G
A
E
Y
K
R
V
G
I
A
P
S
I
T
F
G
L
D
T
P
T
R
A
T
L
S
Y
Y
Y
L
Q
T
D
D
-
K
P
---
D
-
S
G
---
I
P
Y
W
D
------
S
S
LGKAQ
G
K
P
A
-
E
---
V
K
Q
G
T
Y
Y
GW-
K
---
D
---
R
D
F
Q
K
Q
E
N
H
I
G
T
I
K
L
E
H
D
L
--
T
D
N
I
T
I
T
N
T
A
M
Y
A
K
S
K
N
D
Y
V
W
T
--
N
P
-----------------
D
-----
D
-
S
K
G
N
------
V
-
G
-
K
G--
L
V
----
W
--
H
---
R
-
L
-
N
S
A
I
T
D
S
E
T
--
F
--
T
D
Q
L
A
L
T
G
K
F
--
D
T
G
F
L
K
H
R
F
N
V
G
A
E
Y
S
K
Q
K
T
D
K
G
G
Y
N
I
------------
I
-
D
AK
G
---------
N
---------------------
V
SSTGFYSDCSDLST---------
N
----
W
CTSL
N
-----
G
-------
P
--
T
Q
K
-
P
F
V
D
R
L
Q
A
R
---------------
P
D
F
D
A
T
V
E
S
T
S
V
Y
L
L
D
N
I
E
I
T
P
-
K
W
L
L
D
L
G
L
R
W
D
K
F
E
A
E
Q
N
F
L
A
T
S
S
----
A
A
A
Y
T
A
K
N
N
S
D
F
V
T
Y
Q
A
G
I
T
F
K
P
T
E
N
G
S
I
Y
T
S
Y
A
T
S
A
S
P
V
G
L
N
A
G
---
W
G
D
N
S
----------
E
TI
N
A
N
N
Q
-
M
I
D
P
E
E
A
Q
T
F
E
I
G
T
K
W
D
F
-
L
D-----
N
-
H
L
--
N
L
T
A
A
I
---
F
R
T
E
K
Q
N
T
R
V
Q
I
D
-------------------
P
T
---
T
Y
A
N
V
G
E
S
K
V
D
G
F
E
L
G
L
N
G
E
I
T
------
D
-----
K
W
N
I
S
-
A
G
Y
T
Y
L
D
S
E
L
T
K
N
G
K
S
C
R
SG
K
C
T
D
Q
S
I
Y
N
-----
G
N
Q
M
P
N
V
P
K
Q
A
A
T
L
W
T
T
Y
K
V
L
---
P
----
Q
L
T
V
----
G
A
G
A
V
Y
S
D
K
V
Y
-------
G
D
V
A
---------
N
T
K
W
V
---------
P
S
Y
V
R
Y
D
A
M
A
R
Y
N
V
N
-------
K
N
V
D
----
L
Q
L
N
I
N
N
L
S
D
K
R
Y
F
T
K
A
Y
A
-------
S
H
Y
A
T
E
A
E
G
R
S
A
V
L
A
V
N
F
K
Y
--
26
HHSearch
59.92
20%
35
- C4 -
-
1FI1
8
FHUA_ECOLI
A:
[7-707]
--------------------------------------------------
A
A
T
I
A
------------
A
R
Q
S
-
A
T
------------------
G
------------
T
-------------
K
---------------------
T
D
----
T
P
I
Q
K
V
P
Q
S
I
S
V
V
T
A
E
E
M
A
L
-
H
Q
P
K
S
V
K
E
A
L
S
Y
T
P
G
V
S
V
-
G
T
R
G
A
-
S
N
T
---
Y
---
D
H
L
I
I
R
G
F
A
A
E
G
----
Q
S
Q
N
--------
N
Y
L
N
G
L
K
L
Q
G
-
N
---
F
-----
Y
N
--
D
A
--
V
-----
I
D
P
Y
M
L
E
R
A
E
I
M
R
G
P
V
S
V
L
Y
G
K
S
-
S
P
-
G
G
L
L
N
M
V
S
K
R
P
T
T
E
P
------
L
K
E
------
V
Q
F
K
A
G
-----
T
-----
D
S
L
--
F
----
Q
T
G
F
D
F
S
D
S
L
D
D
D
G
V
Y
S
Y
R
L
T
G
L
A
R
S
A
--
N
------
A
Q
Q
K
---
G
S
E
E
Q
R
Y
A
I
A
P
A
F
T
W
R
P
D
D
K
T
N
F
T
F
L
S
Y
F
Q
N
E
P
E
T
G
Y
---
Y
-
G
W
---
L
P
K
E
G
TVEP--
L
P
-----
N
G
K
R
-
L
---
P
T
-
D
F
N
E
G--
A
---
K
---
N
N
T
Y
S
R
N
E
K
M
V
G
Y
S
F
D
H
E
F
--
N
D
T
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
N
S
V
Y
G
Y
G
-----------------
V
CSDP-
A
N
A
-
Y
S
------
K
-
Q
-
C
AAL
A
P
ADKG
H
--
Y
L
A
R
K
-
Y
-
V
V
D
D
E
K
L
Q
N
--
F
--
S
V
D
T
Q
L
Q
S
K
F
--
A
T
G
D
I
D
H
T
L
L
T
G
V
D
F
M
R
M
R
N
D
I
N
A
W
F
G
------------
Y
D
D
--
S
---------
V
---------------------
P
L
L
NLYNPSSHHHHHHG
S
S
V
N
T
D
F
D
----
F
----
N
AK---
D
-------
P
--
A
N--
S
------
G
P
---------------
Y
R
I
L
N
K
Q
K
Q
T
G
V
Y
V
Q
D
Q
A
Q
W
-
D
-
K
V
L
V
T
L
G
G
R
Y
D
W
A
D
Q
E
S
L
N
R
V
A
--------
G
T
T
D
K
R
D
D
K
Q
F
T
W
R
G
G
V
N
Y
L
F
D
N
G
V
T
P
Y
F
S
Y
S
E
S
F
E
P
S
S
Q
V
G
K
----------------------
D
G
N
I
--
F
A
P
S
K
G
K
Q
Y
E
V
G
V
K
Y
V
P
-
E
------
D
R
P
I
--
V
V
T
G
A
V
---
Y
N
L
T
K
T
N
N
L
M
A
D
P
E
-----------------
G
S
F
---
F
S
V
E
G
G
E
I
R
A
R
G
V
E
I
E
A
K
A
A
L
S
------
A
-----
S
V
N
V
V
-
G
S
Y
T
Y
T
D
A
E
Y
T
T
D
T
------------
T
Y
K
-----
G
N
T
P
A
Q
V
P
K
H
M
A
S
L
W
A
D
Y
T
F
F
---
D
GPLS
G
L
T
L
----
G
T
G
G
R
Y
T
G
S
S
Y
-------
G
D
P
A
---------
N
S
F
K
V
---------
G
S
Y
T
V
V
D
A
L
V
R
Y
D
L
A
-
R
V--
G
M
A
G
S
N
----
V
A
L
H
V
N
N
L
F
D
R
E
Y
V
A
S
C
F
N
-------
T
Y
G
C
F
W
G
A
E
R
Q
V
V
A
T
A
T
F
R
F
--
23
HHSearch
58.35
20%
34
- C4 -
-
4CU4
22
FHUA_ECOLI (first)
A:
[5-706]
-------------------------------------------------
P
A
A
T
I
A
------------
A
R
Q
S
-
A
T
------------------
G
------------
T
-------------
K
---------------------
T
D
----
T
P
I
Q
K
V
P
Q
S
I
S
V
V
T
A
E
E
M
A
L
-
H
Q
P
K
S
V
K
E
A
L
S
Y
T
P
G
V
S
V
-
G
T
R
G
A
-
S
N
T
---
Y
---
D
H
L
I
I
R
G
F
A
A
E
G
----
Q
S
Q
N
--------
N
Y
L
N
G
L
K
L
Q
G
-
N
---
F
-----
Y
N
--
D
A
--
V
-----
I
D
P
Y
M
L
E
R
A
E
I
M
R
G
P
V
S
V
L
Y
G
K
S
-
S
P
-
G
G
L
L
N
M
V
S
K
R
P
T
T
E
P
------
L
K
E
------
V
Q
F
K
A
G
-----
T
-----
D
S
L
--
F
----
Q
T
G
F
D
F
S
D
S
L
D
D
D
G
V
Y
S
Y
R
L
T
G
L
A
R
S
A
--
N
------
A
Q
Q
K
---
G
S
E
E
Q
R
Y
A
I
A
P
A
F
T
W
R
P
D
D
K
T
N
F
T
F
L
S
Y
F
Q
N
E
P
E
T
G
Y
---
Y
-
G
W
---
L
P
K
E
G
------
T
V
E----
P
L
P
N
G
K
---
R
L
-
P
T
D
F
---
N
---
E
GAK
N
N
T
Y
S
R
N
E
K
M
V
G
Y
S
F
D
H
E
F
--
N
D
T
F
T
V
R
Q
N
L
R
F
A
E
N
K
T
S
Q
N
S
V
--
Y
G
Y----------------
G
VCSDP
A
N
A
-
Y
S
K
Q
C
A
A
L
A
-
P
-
A
DK-
G
H
----
Y
L
A
R
---
K
-
Y
-
V
V
D
D
E
K
L
Q
N
--
F
--
S
V
D
T
Q
L
Q
S
K
F
--
A
T
G
D
I
D
H
T
L
L
T
G
V
D
F
M
R
M
R
N
D
I
N
A
W
F
G
------------
Y
-
D
--
D
---------
S
V
--------------------
P
L
L
N
LYNN
T
D
F
-------------
D
----
F
----
N
AK---
D
-------
P
--
A
N--
S
------
G
P
---------------
Y
R
I
L
N
K
Q
K
Q
T
G
V
Y
V
Q
D
Q
A
Q
W
-
D
-
K
V
L
V
T
L
G
G
R
Y
D
W
A
D
Q
E
S
L
N
R
V
A
--------
G
T
T
D
K
R
D
D
K
Q
F
T
W
R
G
G
V
N
Y
L
F
D
N
G
V
T
P
Y
F
S
Y
S
E
S
F
E
P
S
S
Q
V
G
K
----------------------
D
G
N
I
--
F
A
P
S
K
G
K
Q
Y
E
V
G
V
K
Y
V
P
-
E
------
D
R
P
I
--
V
V
T
G
A
V
---
Y
N
L
T
K
T
N
N
L
M
A
D
P
E
-----------------
G
S
F
---
F
S
V
E
G
G
E
I
R
A
R
G
V
E
I
E
A
K
A
A
L
S
------
A
-----
S
V
N
V
V
-
G
S
Y
T
Y
T
D
A
E
Y
T
T
D
T
------------
T
Y
K
-----
G
N
T
P
A
Q
V
P
K
H
M
A
S
L
W
A
D
Y
T
F
F
---
D
GPLS
G
L
T
L
----
G
T
G
G
R
Y
T
G
S
S
Y
-------
G
D
P
A
---------
N
S
F
K
V
---------
G
S
Y
T
V
V
D
A
L
V
R
Y
D
L
A
-
R
V--
G
M
A
G
S
N
----
V
A
L
H
V
N
N
L
F
D
R
E
Y
V
A
S
C
F
N
T
-------
Y
G
C
F
W
G
A
E
R
Q
V
V
A
T
A
T
F
R
F
--
24
HHSearch
58.16
18%
53
- C4 -
-
2W16
2
FPVA_PSEAE
A:
[101-772]
--------------------------------------------------
S
G
S
Y
T
------------
P
G
T
I
-
A
T
------------------
A
------------
T
-------------
R
---------------------
L
V
----
L
T
P
R
E
T
P
Q
S
I
T
V
V
T
R
Q
N
M
D
D
-
F
G
L
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
-
S
A
Y
D
T
---
D
---
R
---
N
N
Y
Y
A
R
G
F
S
I
--------
N
N
--------
F
Q
Y
D
G
I
P
S
T
A
-
R
N--
V
G
Y
S
--
A
G
--
N
T
--
L
-----
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
-
A
G
S
L
-
G
A
T
I
N
L
I
R
K
K
P
T
H
E
F
------
K
G
H
------
V
E
L
G
A
G
-----
S
-----
W
D
N
--
Y
----
R
S
E
L
D
V
S
G
P
L
T
E
S
G
N
V
R
G
R
A
V
A
A
Y
Q
D
K
--
H
------
S
F
M
D
---
H
Y
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
P
D
T
M
L
T
V
G
A
D
Y
Q
D
N
D
P
-
K
G
---
S
-
G
W
SGS
F
P
L
F
D
------
S
Q
-----
G
N
R
N
-
D
V
S
R
S
F
-
N
N
G
A
---
K
---
W
----
S
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
--
A
N
G
W
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
--
A
I
-----------------
M
-----
G
-
D
-
W
P
------
A
-
P
D
N
---
S
A
----
K
--
I
---
V
-
A
-
Q
K
Y
T
G
E
T
K
S
--
N
--
S
L
D
I
Y
L
T
G
P
F
--
Q
F
L
G
R
E
H
E
L
V
V
G
T
S
A
S
F
S
H
W
E
G
K
S
Y
W
N
------------
L
-
R
NY
D
NTTDDFINW
D
---------------------
G
-----------------------
D
----
I
----
G
-----
K
-------
P
DW
G
---
T
------
P
S
---------------
Q
Y
I
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
L
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
G
L
N
-------------
P
T
I
R
E
S
G
R
F
I
P
Y
V
G
A
V
Y
D
L
N
D
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
Q
D
S
W
Y
R
---
D
------------------
S
S
N
K
-
L
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
Y
-
L
D-----
G
-
R
L
--
N
T
S
L
A
Y
---
F
E
I
H
E
E
N
R
A
E
E
D
A
L
---
Y
------
N
S
KPTNP
A
I
T
---
Y
A
Y
K
G
I
K
A
K
T
K
G
Y
E
A
E
I
S
G
E
L
A
------
P
-----
G
W
Q
V
Q
-
A
G
Y
T
H
K
I
I
R
D
D
S
----------------
G
-----
K
K
V
S
T
W
E
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
AL
D
----
K
L
T
V
----
G
G
G
A
R
W
Q
G
K
S
W
-------
Q
M
V
Y
NNPRS
R
W
--
E
K
F
S
Q
---------
E
D
Y
W
L
V
D
L
M
A
R
Y
Q
I
T
-------
D
K
L
S
----
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
F
Y
-------
T
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
R
W
D
F
--
34
HHSearch
57.14
18%
39
* C4 *
-
1KMO
17
FECA_ECOLI
A:
[114-774]
--------------------------------------------------------------------
A
L
T
-
V
V
------------------
G
------------
D
-------------
W
---------------------
L
G
DAR
E
N
D
V
F
E
H
A
G
A
R
D
V
I
R
R
E
D
F
A
K
-
T
G
A
T
T
M
R
E
V
L
N
R
I
P
G
V
S
A
-
P
E
N
N
G
-
T
G
S
HDL
A
---
M
N
F
G
I
R
G
L
N
P
R
L
---
A
S
R
S
T
--------
V
L
M
D
G
I
P
V
P
F
-
A
P--
Y
G
-
Q
PQ
L
S
--
L
A
--
P
-----
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
P
Q
-
S
V
-
G
G
V
V
N
F
V
T
R
A
I
P
Q
D
F
------
G
I
E
------
A
G
V
E
G
Q
-----
L
S
PTSS
Q
N
N
P
K
E
----
T
H
N
L
M
V
G
G
T
A
--
D
N
G
F
G
T
A
L
L
Y
S
G
T
R
G
--
S
------
D
W
R
E
---
H
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
V
H
T
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
M
---
P
-
G
G
---
L
S
R
A
D
------
Y
D
-----
A
D
R
W
-
Q
-------
S
T
R
---
P
---
Y
---
D
-
R
F
W
G
R
R
K
L
A
S
L
G
Y
Q
F
Q
P
--
D
S
Q
H
K
F
N
I
Q
G
F
Y
T
Q
T
L
R
S
G
Y
L
E
--
Q
G
-----------------
K
-------------------------------
R
--
I
-------
T
L
S
P
R
N
Y
W
V
--
R
--
G
I
E
P
R
Y
S
Q
I
F
--
M
I
G
P
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
E
M
R
Y
Y
T
------------
A
-
T
--
S
---------
S
---------------------
G
-----------------------
Q
----
L
P---
S
-----
G
-------
S
--
S
---
P
------
Y
D
---------------
R
D
T
R
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
I
G
--
N
W
T
I
T
P
G
M
R
F
E
H
I
E
S
Y
Q
N
N
A
I
T
--------
G
T
H
E
E
V
S
Y
N
A
P
L
P
A
L
N
V
L
Y
H
L
T
D
S
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
I
---
G
K
A
----------------
V
Q
S
G
-
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
--
D
------
G
-
A
L
--
T
A
E
M
G
L
---
F
L
I
N
F
N
N
Q
Y
D
S
N
Q
T
------------------
N
D
---
T
V
T
A
R
G
K
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
TLTPTL
D
-----
N
V
S
I
Y
-
A
S
Y
A
Y
V
N
A
E
I
R
E
K
G
------------
D
T
Y
-----
G
N
L
V
P
F
S
P
K
H
K
G
T
L
G
V
D
Y
K
P
G
--------
N
W
T
F
----
N
L
N
S
D
F
Q
S
S
Q
F
-------
A
D
N
A
NTVKESADG
S
T
G
R
I
---------
P
G
F
M
L
W
G
A
R
V
A
Y
D
F
G
-
P
---
Q
M
A
D
L
N
----
L
A
F
G
V
K
N
I
F
D
Q
D
Y
F
I
R
S
Y
D
D
N
-----
N
K
G
I
Y
A
G
Q
P
R
T
L
Y
M
Q
G
S
L
K
F
--
4
PsiBlast_PDB
56.81
20%
45
- C4 -
-
1PO3
-
FECA_ECOLI
A:
[130-723]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
G
T
-
G
S
H
---
D
---
L
A
M
N
---------
F
G
I
R
G
L
N
PRLASR
S
T
V
L
M
D
G
I
P
V
P
F
A
P
---
Y
G
-
Q
--
P
Q
--
L
S
LA
P
-----
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
-
P
-
Q
S
-
V
G
G
V
V
N
F
V
T
R
A
I
P
Q
D
F
-----
G
I
E
A
G
V
E
G
Q
L
S
P
T
S
S
-----
Q
-----
N
N
P
--
K
----
E
T
H
N
L
M
V
G
G
T
A
D
N
G
F
G
T
A
L
L
Y
S
G
T
R
G
S
--
D
-------
W
R
E
---
H
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
V
H
T
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
M
---
P
-
G
G
---
L
S
R
A
D
------
Y
D
-----
A
D
R
W
-
Q
---
S
T
-
R
P
Y
D
---
R
---
F
---
W
G
R
R
K
L
----
A
S
L
G
Y
Q
F
Q
P
--
D
S
Q
H
K
F
N
I
Q
G
F
Y
T
Q
T
L
R
S
G
Y
L
E
--
Q
G
-----------------
K
-----
R
-
I
-
T
L
------
S
-
P
----------------------------
R
N
Y
--
W
V
R
G
I
E
P
R
Y
S
Q
I
F
--
M
-
I
G
P
-
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
E
M
R
Y
------------
Y
-
T
--
A
---------
T
SSG
Q
L
P
S
--------------
G
-----------------------
S
----
S
----
P
-----
Y
-------
D
--
R
---
D
------
T
R
---------------
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
-----
I
G
-
N
W
T
I
T
P
G
M
R
F
E
H
I
----
E
S
Y
Q
N
N
A
I
---
T
G
T
H
E
-
E
V
S
Y
N
A
P
L
P
A
L
N
V
L
Y
H
L
T
D
S
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
I
---
G
K
A
V
Q
----------
S
--
G
-----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
--
D
GA
L
T
A
-
E
-
M
G
--
L
F
L
I
N
F
N
N
Q
Y
D
S
N
Q
T
N
D
T
V
T
A
R
G
-----------------------------
K
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
------
T
LTPTL
D
N
V
S
I
Y
A
S
Y
A
Y
V
N
A
--------------
E
I
R
E
K
G
D
TY---
G
N
L
V
P
F
S
P
K
H
K
G
T
L
G
V
D
Y
K
P
G
---
N
----
W
T
F
N
L
N
S
D
F
Q
S
S
Q
F
A
D
N
A
N
-------
T
V
K
E
---------
S
A
D
G
S
T
G
R
I
-----
P
G
F
M
L
W
G
A
R
V
A
Y
D
F
G
-
P
---
Q
M
A
D
L
N
----
L
A
F
G
V
K
N
I
F
D
Q
D
Y
-----------------------------------
25
HHSearch
56.67
18%
51
- C4 -
-
2W75
2
FPVA_PSEAE
A:
[101-772]
--------------------------------------------------
S
G
S
Y
T
------------
P
G
T
I
-
A
T
------------------
A
------------
T
-------------
R
---------------------
L
V
----
L
T
P
R
E
T
P
Q
S
I
T
V
V
T
R
Q
N
M
D
D
-
F
G
L
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
-
S
A
Y
D
T
---
D
---
R
---
N
N
Y
Y
A
R
G
F
S
I
--------
N
N
--------
F
Q
Y
D
G
I
P
S
T
A
-
R
N--
V
G
Y
S
--
A
G
--
N
T
--
L
-----
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
-
A
G
S
L
-
G
A
T
I
N
L
I
R
K
K
P
T
H
E
F
------
K
G
H
------
V
E
L
G
A
G
-----
S
-----
W
D
N
--
Y
----
R
S
E
L
D
V
S
G
P
L
T
E
S
G
N
V
R
G
R
A
V
A
A
Y
Q
D
K
--
H
------
S
F
M
D
---
H
Y
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
P
D
T
M
L
T
V
G
A
D
Y
Q
D
N
D
P
-
K
G
---
S
-
G
W
SGS
F
P
L
F
D
------
S
Q
-----
G
N
R
N
-
D
V
S
R
S
F
-
N
N
G
A
---
K
---
W
----
S
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
--
A
N
G
W
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
--
A
I
-----------------
M
-----
G
-
D
-
W
P
------
A
-
P
D
N
---
S
A
----
K
--
I
---
V
-
A
-
Q
K
Y
T
G
E
T
K
S
--
N
--
S
L
D
I
Y
L
T
G
P
F
--
Q
F
L
G
R
E
H
E
L
V
V
G
T
S
A
S
F
S
H
W
E
G
K
S
Y
W
N
------------
L
-
R
NY
D
NTTDDFINW
D
---------------------
G
-----------------------
D
----
I
----
G
-----
K
-------
P
DW
G
---
T
------
P
S
---------------
Q
Y
I
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
L
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
G
L
N
-------------
P
T
I
R
E
S
G
R
F
I
P
Y
V
G
A
V
Y
D
L
N
D
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
Q
D
S
W
Y
R
---
D
------------------
S
S
N
K
-
L
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
Y
-
L
D-----
G
-
R
L
--
N
T
S
L
A
Y
---
F
E
I
H
E
E
N
R
A
E
E
D
A
L
---
Y
------
N
S
KPTNP
A
I
T
---
Y
A
Y
K
G
I
K
A
K
T
K
G
Y
E
A
E
I
S
G
E
L
A
------
P
-----
G
W
Q
V
Q
-
A
G
Y
T
H
K
I
I
R
D
D
S
----------------
G
-----
K
K
V
S
T
W
E
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
AL
D
----
K
L
T
V
----
G
G
G
A
R
W
Q
G
K
S
W
-------
Q
M
V
Y
NNPRS
R
W
--
E
K
F
S
Q
---------
E
D
Y
W
L
V
D
L
M
A
R
Y
Q
I
T
-------
D
K
L
S
----
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
F
Y
-------
T
S
A
S
Y
G
D
P
R
N
L
M
F
S
T
R
W
D
F
--
2
PsiBlast_PDB
55.54
20%
44
- C4 -
-
1PNZ
-
FECA_ECOLI
A:
[120-713]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
G
T
-
G
S
H
---
D
---
L
A
M
N
---------
F
G
I
R
G
L
N
PRLASRST
V
L
M
D
G
I
P
V
P
F
A
P
---
Y
G
-
Q
--
P
Q
--
L
S
LA
P
-----
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
-
P
-
Q
S
-
V
G
G
V
V
N
F
V
T
R
A
I
P
Q
D
F
-----
G
I
E
A
G
V
E
G
Q
L
S
P
T
S
S
-----
Q
-----
N
N
P
--
K
----
E
T
H
N
L
M
V
G
G
T
A
D
N
G
F
G
T
A
L
L
Y
S
G
T
R
G
S
--
D
-------
W
R
E
---
H
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
V
H
T
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
M
---
P
-
G
G
---
L
S
R
A
D
------
Y
D
-----
A
D
R
W
-
Q
---
S
T
-
R
P
Y
D
---
R
---
F
---
W
G
R
R
K
L
----
A
S
L
G
Y
Q
F
Q
P
--
D
S
Q
H
K
F
N
I
Q
G
F
Y
T
Q
T
L
R
S
G
Y
L
E
--
Q
G
-----------------
K
-----
R
-
I
-
T
L
------
S
-
P
----------------------------
R
N
Y
--
W
V
R
G
I
E
P
R
Y
S
Q
I
F
--
M
-
I
G
P
-
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
E
M
R
Y
------------
Y
-
T
--
A
---------
T
SSG
Q
L
P
S
--------------
G
-----------------------
S
----
S
----
P
-----
Y
-------
D
--
R
---
D
------
T
R
---------------
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
-----
I
G
-
N
W
T
I
T
P
G
M
R
F
E
H
I
----
E
S
Y
Q
N
N
A
I
---
T
G
T
H
E
-
E
V
S
Y
N
A
P
L
P
A
L
N
V
L
Y
H
L
T
D
S
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
I
---
G
K
A
V
Q
----------
S
--
G
-----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
--
D
GA
L
T
A
-
E
-
M
G
--
L
F
L
I
N
F
N
NQ
Y
D
S
N
Q
T
N
D
T
V
T
A
R
G
-----------------------------
K
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
------
T
LTPTL
D
N
V
S
I
Y
A
S
Y
A
Y
V
N
A
--------------
E
I
R
E
K
G
D
TY---
G
N
L
V
P
F
S
P
K
H
K
G
T
L
G
V
D
Y
K
P
G
---
N
----
W
T
F
N
L
N
S
D
F
Q
S
S
Q
F
A
D
N
A
N
-------
T
V
K
E
---------
S
A
D
G
S
T
G
R
I
-----
P
G
F
M
L
W
G
A
R
V
A
Y
D
F
G
-
P
---
Q
M
A
D
L
N
----
L
A
F
G
V
K
N
I
F
D
Q
D
Y
-----------------------------------
22
HHSearch
55.47
19%
37
- C4 -
-
3FHH
1
?
A:
[2-640]
-------------------------------------------------------------------
E
T
M
T
-
V
T
------------------
A
------------
T
-------------
G
---------------------
N
A
----
R
S
S
F
E
A
P
M
M
V
S
V
I
D
T
S
A
P
E
N
-
Q
T
A
T
S
A
T
D
L
L
R
H
V
P
G
I
T
L
-
D
G
T
G
R
--
T
N
---
G
---
Q
D
I
N
M
R
G
Y
D
H
R
------
G
V
L
--------
V
L
V
D
G
I
R
Q
G
T
-
D
---
T
G
-
H
--
L
N
--
G
T
--
F
-----
L
D
P
A
L
I
K
R
V
E
I
V
R
G
P
S
A
L
L
Y
G
S
G
-
A
L
-
G
G
V
I
S
Y
D
T
V
D
A
K
D
L
L
QEGQS
S
G
F
R
------
V
F
G
T
G
G
-----
T
-----
G
D
H
S
-
L
----
G
L
G
A
S
A
F
G
R
---
T
E
N
L
D
G
I
V
A
W
S
S
R
D
R
--
G
D
LRQSN
G
E
T
A
---
P
N
D
E
S
I
N
N
M
L
A
K
G
T
W
Q
I
D
S
A
Q
S
L
S
G
L
V
R
Y
Y
N
N
D
A
-
R
E
---
P
-
K
N
---
P
Q
T
--------
V
E
-----
A
S
E
--
S
---
S
N
-
P
--------------
M
V
D
R
S
T
I
Q
R
D
A
Q
L
S
Y
K
L
A
P
QG
N
D
W
L
N
A
D
A
K
I
Y
W
S
E
V
R
I
N
A
Q
------------------------------------------------------------------
E
Y
R
--
E
Q
I
T
--
K
--
G
A
R
L
E
N
R
S
T
L
FA
D
-
S
F
A
S
H
L
L
T
Y
G
G
E
Y
Y
R
Q
E
Q
G
S
H
-------------------------------------------------------------------------------------------------------------------
T
T
---------------
G
F
P
Q
A
K
I
D
F
S
S
G
W
L
Q
D
E
I
T
L
R
D
L
P
I
T
L
L
G
G
T
R
Y
D
S
Y
R
G
S
S
D
G
-------------
Y
K
D
V
D
A
D
K
W
S
S
R
A
G
M
T
I
N
P
T
N
W
L
M
L
F
G
S
Y
A
Q
A
F
R
A
P
T
M
G
E
M
---
Y
N
D
S
K
HFSIGRF
Y
T
N
Y
--
W
V
P
N
P
-
N
L
R
P
E
T
N
E
T
Q
E
Y
G
F
G
L
R
F
-
D
DLMLSN
D
-
A
L
--
E
F
K
A
S
Y
---
F
D
T
K
A
K
D
Y
I
S
T
T
V
D
---
F
------
A
A-----
A
T
T
---
M
S
Y
N
V
P
N
A
K
I
W
G
W
D
V
M
T
K
Y
T
T
-------
D
-----
L
F
S
L
D
-
V
A
Y
N
R
T
R
G
K
D
T
D
----------------
T
-----
G
E
Y
I
S
S
I
N
P
D
T
V
T
S
T
L
N
I
P
I
A
H--
S
----
G
F
S
V
----
G
W
V
G
T
F
A
D
R
S
T
-------
H
I
S
S
------------
K
Q
---------
P
G
Y
G
V
N
D
F
Y
V
S
Y
Q
G
Q
-
Q
---
A
L
K
G
M
T
----
T
T
L
V
L
G
N
A
F
D
K
E
Y
W
S
P
------------
Q
G
I
P
Q
D
G
R
N
G
K
I
F
V
S
Y
Q
W
--
1
PsiBlast_PDB
55.44
20%
42
- C4 -
-
1KMO
17
FECA_ECOLI
A:
[153-746]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
G
T
-
G
S
H
---
D
---
L
A
M
N
---------
F
G
I
R
G
L
N
PRLASRST
V
L
M
D
G
I
P
V
P
F
A
P
---
Y
G
-
Q
--
P
Q
--
L
S
LA
P
-----
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
-
P
-
Q
S
-
V
G
G
V
V
N
F
V
T
R
A
I
P
Q
D
F
-----
G
I
E
A
G
V
E
G
Q
L
S
P
T
S
S
-----
Q
-----
N
N
P
--
K
----
E
T
H
N
L
M
V
G
G
T
A
D
N
G
F
G
T
A
L
L
Y
S
G
T
R
G
S
--
D
-------
W
R
E
---
H
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
V
H
T
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
M
---
P
-
G
G
---
L
S
R
A
D
------
Y
D
-----
A
D
R
W
-
Q
---
S
T
-
R
P
Y
D
---
R
---
F
---
W
G
R
R
K
L
----
A
S
L
G
Y
Q
F
Q
P
--
D
S
Q
H
K
F
N
I
Q
G
F
Y
T
Q
T
L
R
S
G
Y
L
E
--
Q
G
-----------------
K
-----
R
-
I
-
T
L
------
S
-
P
----------------------------
R
N
Y
--
W
V
R
G
I
E
P
R
Y
S
Q
I
F
--
M
-
I
G
P
-
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
E
M
R
Y
------------
Y
-
T
--
A
---------
T
SSGQLPS--------------
G
-----------------------
S
----
S
----
P
-----
Y
-------
D
--
R
---
D
------
T
R
---------------
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
-----
I
G
-
N
W
T
I
T
P
G
M
R
F
E
H
I
----
E
S
Y
Q
N
N
A
I
---
T
G
T
H
E
-
E
V
S
Y
N
A
P
L
P
A
L
N
V
L
Y
H
L
T
D
S
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
I
---
G
K
A
V
Q
----------
S
--
G
-----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
--
D
GA
L
T
A
-
E
-
M
G
--
L
F
L
I
N
F
N
NQ
Y
D
S
N
Q
T
N
D
T
V
T
A
R
G
-----------------------------
K
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
------
T
LTPTL
D
N
V
S
I
Y
A
S
Y
A
Y
V
N
A
-----------------
E
I
R
E
KGDTY
G
N
L
V
P
F
S
P
K
H
K
G
T
L
G
V
D
Y
K
P
G
---
N
----
W
T
F
N
L
N
S
D
F
Q
S
S
Q
F
A
D
N
A
N
-------
T
V
K
E
---------
S
A
D
G
S
T
G
R
I
-----
P
G
F
M
L
W
G
A
R
V
A
Y
D
F
G
-
P
---
Q
M
A
D
L
N
----
L
A
F
G
V
K
N
I
F
D
Q
D
Y
-----------------------------------
3
PsiBlast_PDB
55.18
20%
45
- C4 -
-
1PO0
-
FECA_ECOLI
A:
[130-723]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
V
L
N
R
I
P
G
V
S
A
P
E
N
N
G
T
-
G
S
H
---
D
---
L
A
M
N
---------
F
G
I
R
G
L
N
PRLASR
S
T
V
L
M
D
G
I
P
V
P
F
A
P
---
Y
G
-
Q
--
P
Q
--
L
S
LA
P
-----
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
-
P
-
Q
S
-
V
G
G
V
V
N
F
V
T
R
A
I
P
Q
D
F
-----
G
I
E
A
G
V
E
G
Q
L
S
P
T
S
S
-----
Q
-----
N
N
P
--
K
----
E
T
H
N
L
M
V
G
G
T
A
D
N
G
F
G
T
A
L
L
Y
S
G
T
R
G
S
--
D
-------
W
R
E
---
H
S
A
T
R
I
D
D
L
M
L
K
S
K
Y
A
P
D
E
V
H
T
F
N
S
L
L
Q
Y
Y
D
G
E
A
-
D
M
---
P
-
G
G
---
L
S
R
A
D
------
Y
D
-----
A
D
R
W
-
Q
---
S
T
-
R
P
Y
D
---
R
---
F
---
W
G
R
R
K
L
----
A
S
L
G
Y
Q
F
Q
P
--
D
S
Q
H
K
F
N
I
Q
G
F
Y
T
Q
T
L
R
S
G
Y
L
E
--
Q
G
-----------------
K
-----
R
-
I
-
T
L
------
S
-
P
----------------------------
R
N
Y
--
W
V
R
G
I
E
P
R
Y
S
Q
I
F
--
M
-
I
G
P
-
S
A
H
E
V
G
V
G
Y
R
Y
L
N
E
S
T
H
E
M
R
Y
------------
Y
-
T
--
A
---------
T
SSGQLPS--------------
G
-----------------------
S
----
S
----
P
-----
Y
-------
D
--
R
---
D
------
T
R
---------------
S
G
T
E
A
H
A
W
Y
L
D
D
K
I
D
-----
I
G
-
N
W
T
I
T
P
G
M
R
F
E
H
I
----
E
S
Y
Q
N
N
A
I
---
T
G
T
H
E
-
E
V
S
Y
N
A
P
L
P
A
L
N
V
L
Y
H
L
T
D
S
W
N
L
Y
A
N
T
E
G
S
F
G
T
V
Q
Y
S
Q
I
---
G
K
A
V
Q
----------
S
--
G
-----
N
V
E
P
E
K
A
R
T
W
E
L
G
T
R
Y
D
--
D
GA
L
T
A
-
E
-
M
G
--
L
F
L
I
N
F
N
NQ
Y
D
S
N
Q
T
N
D
T
V
T
A
R
G
-----------------------------
K
T
R
H
T
G
L
E
T
Q
A
R
Y
D
L
G
------
T
LTPTL
D
N
V
S
I
Y
A
S
Y
A
Y
V
N
A
--------------
E
I
R
E
K
G
D
TY---
G
N
L
V
P
F
S
P
K
H
K
G
T
L
G
V
D
Y
K
P
G
---
N
----
W
T
F
N
L
N
S
D
F
Q
S
S
Q
F
A
D
N
A
N
-------
T
V
K
E
---------
S
A
D
G
S
T
G
R
I
-----
P
G
F
M
L
W
G
A
R
V
A
Y
D
F
G
-
P
---
Q
M
A
D
L
N
----
L
A
F
G
V
K
N
I
F
D
Q
D
Y
-----------------------------------
36
HHSearch
54.86
19%
55
- C4 -
-
5FOK
5
?
A:
[28-721]
---------------------------------------------------------------------------------------------DETTYNVDRSAS
K
-------------
K
---------------------
Y
T
----
A
P
L
L
D
T
P
K
T
V
T
V
I
P
Q
Q
V
I
K
D
-
T
G
A
L
T
L
A
D
A
L
R
T
T
P
G
I
T
F
-
G
A
--------------
D
R
P
F
I
R
G
F
N
A
E
-------
S
D
--------
T
F
L
D
G
M
R
D
V
A
-
S
--------------
Q
--
T
-----
R
E
V
F
N
V
E
Q
I
E
V
S
K
G
P
G
S
A
Y
T
G
A
G
-
S
T
-
G
G
S
L
N
L
I
S
K
T
A
K
Q
D
N
------
F
T
D
------
A
G
F
T
W
G
-----
S
-----
D
Q
T
--
R
----
R
T
T
L
D
V
N
R
M
I
--
G
D
N
A
A
F
R
L
N
L
M
K
H
----
D
------
A
H
V
A
GRD
E
V
S
V
S
R
W
G
V
A
P
T
V
T
F
G
F
D
T
P
T
R
A
T
L
S
Y
Y
H
L
S
T
D
D
-
M
P
---
D
-
Y
G
---
L
P
L
T
N
------
V
N
RSK--
A
N
P
S
-
K
P
AS
V
D
R
D
N
F
Y
---
G
---
L
KD-
R
D
Y
R
K
S
T
T
D
S
G
T
F
R
I
E
H
D
L
--
N
D
N
L
T
L
S
N
S
T
R
L
V
R
T
T
L
D
Y
I
V
S
--
N
P
-----------------
D
-----
D
-
S
-
R
G
NV----
A
-
N
-
G
---
Y
V
----
Y
--
R
---
S
A
K
S
R
N
S
T
S
K
G
W
V
--
N
--
Q
T
D
L
K
A
N
F
E
T
--
G
-
F
I
K
-
H
T
L
V
T
G
L
E
F
S
Y
E
D
V
H
N
R
P
Y
A
I
------------
T
-
S
--
G
---------
G
GAGNTCN
A
R
L
L
A
S
GDCTSLNR
P
-----------------------
T
----
P
----
G
-----
D
NW-----
T
--
G
S
I
T
D
------
G
L
---------------
A
Y
T
D
T
D
T
K
T
S
A
A
Y
V
F
D
T
L
K
L
S
E
-
Q
W
E
L
N
L
G
L
R
Y
D
D
F
D
T
K
S
S
G
Y
Q
T
A
G
R
NG
P
A
G
Y
F
K
R
E
N
N
S
H
F
W
N
Y
Q
T
G
L
V
Y
K
P
A
P
N
G
S
I
Y
L
A
W
S
T
S
S
N
-
P
-------------------------------------
R
N
R
N
L
E
L
G
T
K
W
A
F
-
F
D-----
D
-
A
L
--
S
L
N
A
A
L
---
F
R
T
D
K
T
N
A
R
----------------------------
L
Q
V
L
D
G
E
Q
R
V
Q
G
V
E
L
G
F
N
G
K
L
T
------
E
-----
K
W
K
V
F
-
G
G
Y
T
Y
L
D
S
E
I
R
K
S
T
----------
V
K
S
D
E
-----
G
N
K
M
P
Q
T
A
Q
N
N
F
T
L
W
T
T
Y
D
L
L
---
Q
----
N
F
T
I
----
G
G
G
T
T
Y
V
D
K
Q
Y
-------
G
N
T
A
---------
N
S
T
Y
I
---------
P
S
Y
W
R
Y
D
A
M
A
S
Y
K
V
S
-------
K
N
V
D
----
L
Q
L
N
V
Q
N
L
T
D
K
R
Y
F
D
Q
V
Y
S
-------
T
H
M
A
H
V
A
P
G
R
T
A
L
L
G
V
N
F
H
F
S
A
29
HHSearch
54.74
19%
55
- C4 -
-
3QLB
2
?
A:
[73-748]
------------------------------------------------------------------------------------------------------------------------PDSAT
G
P
Q
A
G
YVAKRSLSGTK
T
D
----
A
S
L
S
E
I
P
Q
S
I
S
V
I
T
R
D
Q
M
D
A
-
Q
Q
V
Q
S
V
N
E
A
L
R
Y
T
A
G
V
Q
A
-
N
T
T
A
A
-
S
Q
R
---
F
---
D
T
L
S
I
R
G
F
D
V
-------
T
T
G
--------
M
L
R
D
G
L
K
G
N
T
-
A
---
Q
------
A
--
W
P
--
K
-----
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
Q
N
-
S
P
-
G
G
V
V
N
Q
I
S
K
R
P
L
D
K
P
------
F
H
E
------
V
Q
I
Q
G
G
-----
S
-----
F
D
R
--
A
----
Q
G
Q
F
D
F
S
G
P
L
D
D
E
G
Q
F
L
Y
R
L
V
G
L
E
R
D
S
--
G
------
T
Q
F
D
---
H
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
N
D
D
T
S
L
T
L
L
A
D
Y
T
Q
D
T
F
-
G
A
---
P
-
R
V
---
F
L
P
A
Q
GT----
L
L
-----
G
N
P
N
-
G
---
K
V
-
R
H
N
V
---
F
LDE
P
---
G
L
D
N
D
R
T
Q
Y
S
L
G
Y
L
L
E
H
R
L
--
N
D
V
W
S
L
N
S
S
A
R
Y
G
H
V
N
L
L
T
N
T
A
--
S
G
-----------------
M
-----
S
-
L
-
A
P
------
D
-
L
-
R
---
T
L
----
N
--
R
---
A
-
A
-
Y
R
F
R
I
V
G
D
T
Y
S
L
--
D
N
N
A
Q
A
R
W
N
L
--
G
--
S
T
Q
M
V
S
L
L
G
I
D
Y
R
R
T
R
E
D
Y
Y
L
R
G
G
------------
S
-
A
--
S
---------
P
I--------------------
D
IY
N
--------------------
P
----
V
H
---
H
H
HGVF
D
-------
P
--
S
---
T
------
P
F
---------------
T
N
T
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
W
V
L
T
V
G
G
R
Q
D
R
S
S
A
R
T
D
N
R
M
N
--------
D
S
G
S
K
Q
D
D
E
K
F
T
Y
R
T
G
L
V
Y
L
A
D
N
G
L
A
P
Y
I
S
Y
S
T
S
F
D
P
V
L
G
T
N
F
-----------------------
Y
G
T
-
P
Y
K
P
T
S
A
K
Q
S
E
V
G
V
K
Y
Q
P
-
P
------
G
I
D
S
--
Y
I
T
L
S
L
---
F
D
L
T
Q
E
N
V
L
T
T
D
P
A
-----------------
Q
R
L
---
N
K
I
Q
T
G
E
I
N
V
R
G
I
E
L
E
G
K
A
S
L
A
------
R
-----
G
L
D
L
L
-
A
A
L
T
Y
N
D
A
E
V
S
K
S
N
----------
N
P
L
E
K
-----
G
K
R
P
T
D
T
P
E
K
M
A
S
L
W
A
D
Y
T
L
P
---
E
GPLS
G
L
G
F
----
G
A
G
V
R
Y
I
G
S
T
E
-------
A
D
A
A
---------
N
T
Q
R
V
---------
P
S
Y
T
L
L
D
A
A
V
H
Y
D
F
D
-
K
LIP
A
A
K
G
L
R
----
L
A
V
N
A
T
N
L
T
D
K
H
Y
Y
E
G
C
S
L
--------
T
N
C
S
A
G
Y
D
R
S
V
I
A
S
L
R
Y
R
W
--
28
HHSearch
54.63
19%
57
- C4 -
-
3QLB
2
?
B:
[73-748]
------------------------------------------------------------------------------------------------------------------------PDSAT
G
P
Q
A
G
YVAKRSLSGTK
T
D
----
A
S
L
S
E
I
P
Q
S
I
S
V
I
T
R
D
Q
M
D
A
-
Q
Q
V
Q
S
V
N
E
A
L
R
Y
T
A
G
V
Q
A
-
N
T
T
A
A
-
S
Q
R
---
F
---
D
T
L
S
I
R
G
F
D
V
-------
T
T
G
--------
M
L
R
D
G
L
K
G
N
T
-
A
---
Q
------
A
--
W
P
--
K
-----
V
E
A
Y
G
L
E
R
I
D
V
L
K
G
P
A
S
V
L
F
G
Q
N
-
S
P
-
G
G
V
V
N
Q
I
S
K
R
P
L
D
K
P
------
F
H
E
------
V
Q
I
Q
G
G
-----
S
-----
F
D
R
--
A
----
Q
G
Q
F
D
F
S
G
P
L
D
D
E
G
Q
F
L
Y
R
L
V
G
L
E
R
D
S
--
G
------
T
Q
F
D
---
H
I
K
D
D
K
Q
Y
F
A
P
S
F
T
W
K
P
N
D
D
T
S
L
T
L
L
A
D
Y
T
Q
D
T
F
-
G
A
---
P
-
R
V
---
F
L
P
A
Q
GT----
L
L
-----
G
N
P
N
-
G
---
K
V
-
R
H
N
V
---
F
LDE
P
---
G
L
D
N
D
R
T
Q
Y
S
L
G
Y
L
L
E
H
R
L
--
N
D
V
W
S
L
N
S
S
A
R
Y
G
H
V
N
L
L
T
N
T
A
--
S
G
-----------------
M
-----
S
-
L
-
A
P
------
D
-
L
-
R
---
T
L
----
N
--
R
---
A
-
A
-
Y
R
F
R
I
V
G
D
T
Y
S
L
--
D
N
N
A
Q
A
R
W
N
L
--
G
--
S
T
Q
M
V
S
L
L
G
I
D
Y
R
R
T
R
E
D
Y
Y
L
R
G
G
------------
S
-
A
--
S
---------
P
I
--------------------
D
IY
N
--------------------
P
----
V
H
---
H
VF---
D
-------
P
--
S
---
T
------
P
F
---------------
T
N
T
V
Q
R
A
D
Q
V
G
V
Y
A
Q
Q
Q
F
T
F
D
E
-
H
W
V
L
T
V
G
G
R
Q
D
R
S
S
A
R
T
D
N
R
M
N
--------
D
S
G
S
K
Q
D
D
E
K
F
T
Y
R
T
G
L
V
Y
L
A
D
N
G
L
A
P
Y
I
S
Y
S
T
S
F
D
P
V
L
G
T
N
F
-----------------------
Y
G
T
-
P
Y
K
P
T
S
A
K
Q
S
E
V
G
V
K
Y
Q
P
-
P
------
G
I
D
S
--
Y
I
T
L
S
L
---
F
D
L
T
Q
E
N
V
L
T
T
D
P
A
-----------------
Q
R
L
---
N
K
I
Q
T
G
E
I
N
V
R
G
I
E
L
E
G
K
A
S
L
A
------
R
-----
G
L
D
L
L
-
A
A
L
T
Y
N
D
A
E
V
S
K
S
N
----------
N
P
L
E
K
-----
G
K
R
P
T
D
T
P
E
K
M
A
S
L
W
A
D
Y
T
L
P
---
E
GPLS
G
L
G
F
----
G
A
G
V
R
Y
I
G
S
T
E
-------
A
D
A
A
---------
N
T
Q
R
V
---------
P
S
Y
T
L
L
D
A
A
V
H
Y
D
F
D
-
K
LIP
A
A
K
G
L
R
----
L
A
V
N
A
T
N
L
T
D
K
H
Y
Y
E
G
C
S
L
--------
T
N
C
S
A
G
Y
D
R
S
V
I
A
S
L
R
Y
R
W
--
35
HHSearch
53.82
19%
51
- C4 -
-
5FOK
3
?
B:
[28-721]
---------------------------------------------------------------------------------------------DETTYNVDRSAS
K
-------------
K
---------------------
Y
T
----
A
P
L
L
D
T
P
K
T
V
T
V
I
P
Q
Q
V
I
K
D
-
T
G
A
L
T
L
A
D
A
L
R
T
T
P
G
I
T
F
-
G
A
G
-------------
D
R
P
F
I
R
G
F
N
A
E
-------
S
D
--------
T
F
L
D
G
M
R
D
V
A
-
S
--------------
Q
--
T
-----
R
E
V
F
N
V
E
Q
I
E
V
S
K
G
P
G
S
A
Y
T
G
A
G
-
S
T
-
G
G
S
L
N
L
I
S
K
T
A
K
Q
D
N
------
F
T
D
------
A
G
F
T
W
G
-----
S
-----
D
Q
T
--
R
----
R
T
T
L
D
V
N
R
M
I
--
G
D
N
A
A
F
R
L
N
L
M
K
H
----
D
------
A
H
V
A
GRD
E
V
S
V
S
R
W
G
V
A
P
T
V
T
F
G
F
D
T
P
T
R
A
T
L
S
Y
Y
H
L
S
T
D
D
-
M
P
---
D
-
Y
G
---
L
P
L
T
N
------
V
N
RSK--
A
N
P
S
-
K
P
AS
V
D
R
D
N
F
Y
---
G
---
L
KD-
R
D
Y
R
K
S
T
T
D
S
G
T
F
R
I
E
H
D
L
--
N
D
N
L
T
L
S
N
S
T
R
L
V
R
T
T
L
D
Y
I
V
S
--
N
P
-----------------
D
-----
D
-
S
-
R
G
NV----
A
-
N
-
G
---
Y
V
----
Y
--
R
---
S
A
K
S
R
N
S
T
S
K
G
W
V
--
N
--
Q
T
D
L
K
A
N
F
E
T
--
G
-
F
I
K
-
H
T
L
V
T
G
L
E
F
S
Y
E
D
V
H
N
R
P
Y
A
I
------------
T
-
S
--
G
---------
G
GAGNTCN
A
R
L
L
A
S
GDCTSLNR
P
-----------------------
T
----
P
----
G
-----
D
NW-----
T
--
G
S
I
T
D
------
G
L
---------------
A
Y
T
D
T
D
T
K
T
S
A
A
Y
V
F
D
T
L
K
L
S
E
-
Q
W
E
L
N
L
G
L
R
Y
D
D
F
D
T
K
S
S
G
Y
Q
T
A
G
R
NG
P
A
G
Y
F
K
R
E
N
N
S
H
F
W
N
Y
Q
T
G
L
V
Y
K
P
A
P
N
G
S
I
Y
L
A
W
S
T
S
S
N
-
P
-------------------------------------
R
N
R
N
L
E
L
G
T
K
W
A
F
-
F
D-----
D
-
A
L
--
S
L
N
A
A
L
---
F
R
T
D
K
T
N
A
----------------------------------
G
E
Q
R
V
Q
G
V
E
L
G
F
N
G
K
L
T
------
E
-----
K
W
K
V
F
-
G
G
Y
T
Y
L
D
S
E
I
R
K
S
T
----------
V
K
S
D
E
-----
G
N
K
M
P
Q
T
A
Q
N
N
F
T
L
W
T
T
Y
D
L
L
---
Q
----
N
F
T
I
----
G
G
G
T
T
Y
V
D
K
Q
Y
-------
G
N
T
A
---------
N
S
T
Y
I
---------
P
S
Y
W
R
Y
D
A
M
A
S
Y
K
V
S
-------
K
N
V
D
----
L
Q
L
N
V
Q
N
L
T
D
K
R
Y
F
D
Q
V
Y
S
-------
T
H
M
A
H
V
A
P
G
R
T
A
L
L
G
V
N
F
H
F
S
A
44
Fugue
52.49
17%
63
- C4 -
-
2IAH
1
FPVA_PSEAE
A:
[1-772]
Q
E
V
E
F
D
I
P
P
QA
L
G
S
A
L
Q
E
F
G
R
Q
A
D
I
Q
V
L
Y
R
P
E
E
V
R
N
K
R
S
S
A
I
K
G
K
L
E
P
N
Q
A
I
T
E
L
L
RGTG
A
S
V
D
F
Q
G
N
A
I
T
-
I
S
VATITEDSGSYTPGTIAT
A
------------
T
-------------
R
---------------------
L
V
----
L
T
P
R
E
T
P
Q
S
I
T
V
V
T
R
Q
N
M
D
D
-
F
G
L
N
N
I
D
D
V
M
R
H
T
P
G
I
T
V
-
S
A
Y
D
T
-
D
R
N
---
N
---
Y
Y
A
--
R
G
F
S
I
N
N
----------------
F
Q
Y
D
G
I
P
S
T
A
-
R
---
N
V
-
G
--
Y
S
AG
N
T
--
L
-----
S
D
M
A
I
Y
D
R
V
E
V
L
K
G
A
T
G
L
L
T
G
-
A
-
G
S
L
G
A
T
I
N
L
I
R
K
K
P
T
H
E
F
------
K
G
H
------
V
E
L
G
A
G
-----
S
-----
W
D
N
--
Y
----
R
S
E
L
D
V
S
G
P
L
T
E
S
G
N
V
R
G
R
A
V
A
A
Y
Q
D
K
--
H
------
S
F
M
D
---
H
Y
E
R
K
T
S
V
Y
Y
G
I
L
E
F
D
L
N
P
D
T
M
L
T
V
G
A
D
Y
Q
D
N
D
P
-
K
G
SGW
S
-
G
S
---
F
P
L
F
D
------
S
Q
-----
G
N
R
N
-
D
---
V
S
-
R
S
F
N
NGA
K
---
W
---
S
S
W
E
Q
Y
T
R
T
V
F
A
N
L
E
H
N
F
A
--
N
G
W
V
G
K
V
Q
L
D
H
K
I
N
G
Y
H
A
P
L
G
A
--
I
M
-----------------
G
-----
D
-
W
-
P
A
------
P
-
D
-
N
---
S
A
----
K
--
I
---
V
-
A
-
Q
K
Y
T
G
E
T
K
S
--
N
--
S
L
D
I
Y
L
T
G
P
F
--
Q
-
F
L
G
-
R
E
H
E
L
V
V
G
T
S
A
S
F
S
H
W
E
G
K
S
Y
------------
W
-
N
--
L
---------
R
---------------------
N
-----------------------
Y
----
D
----
N
-----
T
-------
T
--
D
---
D
------
F
I
NWDG
D
I
G
K
P
DWGTPS
Q
Y
I
D
D
K
T
R
Q
L
G
S
Y
M
T
A
R
F
N
V
T
D
-
D
L
N
L
F
L
G
G
R
V
V
D
Y
R
V
T
-------------
G
L
N
P
T
I
R
E
S
G
R
F
I
P
Y
V
G
A
V
Y
D
L
N
D
T
Y
S
V
Y
A
S
Y
T
D
I
F
M
P
Q
D
--
S
W
---
Y
R
D
S
S
----------
N
--
K
L
-----
L
E
P
D
E
G
Q
N
Y
E
I
G
I
K
G
E
Y
L
D
------
G
-
R
L
--
N
T
S
L
A
Y
---
F
E
I
H
E
E
N
R
A
E
E
D
A
L
---
Y
NSKPTN
P
------
A
I
T
---
Y
A
Y
K
G
I
K
A
K
T
K
G
Y
E
A
E
I
S
G
E
L
A
------
P
-----
G
W
Q
V
Q
-
A
G
Y
T
H
K
I
I
R
D
D
S
G
K
K
-------------
V
-----
S
T
W
E
P
Q
D
Q
L
S
L
Y
T
S
Y
K
F
K
G
A
L
---
D
----
K
L
T
V
----
G
G
G
A
R
W
Q
G
K
S
W
-------
Q
M
V
Y
---------
N
N
P
R
S
---------
R
W
E
K
F
S
Q
E
D
Y
W
L
V
D
L
-
M
---
A
R
Y
Q
I
T
DK
L
S
A
S
V
N
V
N
N
V
F
D
K
T
Y
Y
T
N
I
G
F
Y
T
S
A
S
Y
---------
G
D
P
R
N
L
M
F
S
T
R
W
D
F
6
PsiBlast_PDB
51.22
20%
53
- C4 -
-
1KMP
18
FECA_ECOLI
A:
[180-746]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
I
R
G
L
N
PRLASRST
V
L
M
D
G
I
P
V
P
F
A
P
---
Y
G
-
Q
--
P
Q
--
L
S
LA
P
-----
V
S
L
G
N
M
D
A
I
D
V
V
R
G
G
G
A
V
R
Y
G
-
P
-
Q
S
-
V
G
G
V
V
N
F
V
T
R
A
I
P
Q
D
F
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-----------------------------------
42
Fugue
51.04
16%
51
- C4 -
-
1KMO
17
FECA_ECOLI
A:
[114-774]
----------------------------------------------------
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43
Fugue
50.46
18%
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- C4 -
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1BY5
8
FHUA_ECOLI
A:
[18-714]
--------------------------------------------
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