@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VRW9: (2017-12-05 )
MRTSRFLFATLRETPNDAEVISHQLMLRAGMIRKLASGLYTWLPMGTRVLKKVDAIVREEMNRSGAMEVFMPVTQPASLWEESGRYEQYGPGLLRFKDRHDNPFVLGPTHEEVITDLARNELKSYKQLPVNFYQIQTKFRDEIRPRFGVMRSREFIMKDAYSFHATQESLQETYNVMYDTYSRIFTRLGLDFRPVQADTGSIGGSASHEFHVLAASGEDDIAFSTESDYAANVEMAEAVLVGERAAPTQEFKLVETPNQKTIADVCQFLNADPKQSVKALLVQGVADEKGNVPVVALFLRGDHELNEIKAEKHPLVAAPLAFATEEQLQAFGLTAGFTGPQGLVEKGITVIVDRAASVLSDFVAGANEADKHAVGVNWERDAQITEVFDLRNVVEGDPSPDGKGTLQIKCGIEVGHIFQLGTKYSEALGCKVLGEDGKPFTVTMGCYGIGVTRVVAAAIEQNYDDKGIIWPQAIAPFEIAIVPMNAHKSPRTLEAAEALYAELQAQGFDVLLDDRNERPGVKFSDLELMGIPHRIVIGEKGLDAGTFEYKGRRDAEASNLTKEELLAKLAR
Atome Classification :
(20 SA)
-.........10........20........30--------------..--.-.....40........50........60........70........80.-.......90......----..----100.......110.......120.......130.......140.......150...-..-..160.......170.......180.......190.......200.......210.......220.......230.......-240-.-......-250.......260.......270.......280.......290.......300.......310.......320......-.-330........340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480......-.-490.......500.......510.....--.--.520.......530.......540.......550.......560.....----..570---------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MRTS
R
F
L
F
A
T
L
RETP
N
D
A
E
V
I
S
H
Q
L
M
L
R
A
G
M
--------------
I
R
--
K
-
L
A
S
G
L
Y
T
W
L
P
M
G
T
R
V
L
K
K
V
D
A
I
V
R
E
E
MNRSGA
M
E
V
F
M
PVTQ
P
A
S
L
W
E
E-SGRYEQYGPGL
L
R
FK----DR----HDN
P
F
V
LGP
T
H
E
E
V
I
T
D
L
A
R
N
E
L
K
S
Y
K
QLP
V
N
F
Y
Q
I
Q
T
K
F
R
D
E
I
R
P
R
FG
V
M
R
S
R
E
F
-
I
M
-
K
D
A
Y
SF
H
A
T
Q
E
S
L
Q
E
T
Y
N
V
M
Y
D
T
Y
S
R
I
F
T
R
LGL
D
F
RPVQADTGSIGGSAS
H
E
F
H
V
L
AASGED
D
I
A
FSTESDYAA
N
V
E
M
A
E
A
V
-
L
VG-E-RAAPTQ-
E
F
K
L
VETPNQ
K
T
I
A
D
V
C
Q
F
LNA
D
P
K
Q
S
V
K
A
L
L
V
QGVADEKGNV
P
V
V
A
L
F
LRGDH
E
L
N
E
IKAEKHP
L
V
AA
P
L
A
FA
T
E
E
Q
L
-
Q
-
A
F-GLTAGFTG
P
Q
G
L
V
EKG
I
T
V
I
V
D
R
A
A
S
V
L
S
D
F
V
AGANEADK
H
A
VGVNWERDA
Q
I
T
E
V
F
D
L
R
N
V
VEGDPSPDGK
G
T
L
Q
I
K
CGIEV
G
H
I
F
Q
LGT
K
Y
S
EALG
C
K
V
LGEDGK
P
F
T
V
T
M
G
C
YGI
G
V
T
R
V
V
A
A
A
I
EQNYDDKGIIWPQAIA
P
F
E
I
A
I
V
PMNAHK-S-PR
T
L
E
A
A
E
A
L
Y
A
E
L
Q
AQG
F
D
V
L
LDDRNE--R--PGVKFSD
L
E
L
MGIP
H
R
I
V
I
GEKGLDAGT
F
E
YKGRRDAEASNL
T
K
E
E
L
L
A
----
K
LAR----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.61
65%
-32
- C1 -
-
5UCM
-
SYP_PSEAE
A:
[10-578]
--
R
T
S
Q
Y
L
L
S
-----
P
A
D
A
V
V
I
S
H
Q
L
L
L
R
A
G
M
--------------
I
R
--
R
-
L
A
S
G
L
Y
T
W
L
P
M
G
L
R
V
L
R
K
V
E
T
I
V
R
E
E
M
N
A
A
G
A
L
E
V
L
M
P
A
V
Q
P
A
E
L
W
Q
E
-
S
G
R
W
E
Q
Y
G
P
E
L
L
R
L
K
----
D
R
----
H
E
R
E
F
C
V
G
P
T
H
E
E
V
I
T
D
L
A
R
N
E
L
N
S
Y
K
Q
L
P
I
N
F
Y
Q
I
Q
T
K
F
R
D
E
I
R
P
R
F
G
L
M
R
G
R
E
F
-
I
M
-
K
D
A
Y
S
F
H
L
S
Q
D
S
L
Q
Q
T
Y
D
G
M
Y
Q
A
Y
S
K
I
F
S
R
L
G
L
D
F
R
P
V
Q
A
D
N
G
S
I
G
G
S
G
S
H
E
F
H
V
L
A
N
S
G
E
D
D
I
V
F
S
D
S
S
D
Y
A
A
N
I
E
K
A
E
A
V
P
R
E
S
-
A
-
R
G
S
A
T
E
-
D
M
R
L
V
D
T
P
N
T
K
T
I
A
A
L
V
D
G
F
Q
L
P
I
E
K
T
I
K
T
L
V
V
H
G
A
--
E
E
G
T
--
L
V
A
L
I
V
R
G
D
H
E
L
N
E
I
K
A
A
N
Q
P
L
V
A
S
P
L
V
F
A
S
E
A
E
I
-
R
A
A
I
-
G
A
G
P
G
S
L
G
P
V
N
L
---
P
I
A
C
I
V
D
R
S
V
A
L
M
S
D
F
A
A
G
A
N
I
E
D
K
H
Y
F
G
V
N
W
E
R
D
L
P
L
P
E
V
A
D
L
R
N
V
V
E
G
D
P
S
P
D
G
K
G
T
L
V
I
K
R
G
I
E
V
G
H
I
F
Q
L
G
T
K
Y
S
E
A
M
K
L
S
V
L
S
E
Q
G
K
P
V
N
L
I
M
G
C
Y
G
I
G
V
S
R
V
V
A
A
A
I
E
Q
N
H
D
E
R
G
I
L
W
P
S
A
L
A
P
F
Q
I
A
L
V
P
L
K
-
Y
E
-
T
-
E
S
V
K
Q
A
T
D
K
L
Y
A
E
L
T
A
A
G
F
E
V
L
L
D
D
R
D
K
--
K
TS
P
G
V
K
F
A
D
M
E
L
I
G
I
P
H
R
I
V
I
S
D
R
G
L
S
E
G
V
L
E
Y
K
G
R
R
D
S
E
S
Q
N
L
P
I
G
E
L
M
S
F
I
T
E
K
L
S
-----------------------------------------------------------------------------------------------
61
HHSearch
85.54
67%
-31
- C1 -
-
5UCM
-
SYP_PSEAE
B:
[9-574]
-
M
R
T
S
Q
Y
L
L
S
-----
P
A
D
A
V
V
I
S
H
Q
L
L
L
R
A
G
M
--------------
I
R
--
R
-
L
A
S
G
L
Y
T
W
L
P
M
G
L
R
V
L
R
K
V
E
T
I
V
R
E
E
M
N
A
A
G
A
L
E
V
L
M
P
A
V
Q
P
A
E
L
W
Q
E
-
S
G
R
W
E
Q
Y
G
P
E
L
L
R
L
K
----
D
R
----
H
E
R
E
F
C
V
G
P
T
H
E
E
V
I
T
D
L
A
R
N
E
L
N
S
Y
K
Q
L
P
I
N
F
Y
Q
I
Q
T
K
F
R
D
E
I
R
P
R
F
G
L
M
R
G
R
E
F
-
I
M
-
K
D
A
Y
S
F
H
L
S
Q
D
S
L
Q
Q
T
Y
D
G
M
Y
Q
A
Y
S
K
I
F
S
R
L
G
L
D
F
R
P
V
Q
A
D
N
G
S
I
G
G
S
G
S
H
E
F
H
V
L
A
N
S
G
E
D
D
I
V
F
S
D
S
S
D
Y
A
A
N
I
E
K
A
E
A
V
-
P
R
E
-
S
A
R
G
S
A
T
E
-
D
M
R
L
V
D
T
P
N
T
K
T
I
A
A
L
V
D
G
F
Q
L
P
I
E
K
T
I
K
T
L
V
V
H
G
A
----
E
E
G
T
L
V
A
L
I
V
R
G
D
H
E
L
N
E
I
K
A
A
N
Q
P
L
V
A
S
P
L
V
F
A
S
E
A
E
I
R
A
-
A
I
-
G
A
G
P
G
S
L
G
P
V
N
L
---
P
I
A
C
I
V
D
R
S
V
A
L
M
S
D
F
A
A
G
A
N
I
E
D
K
H
Y
F
G
V
N
W
E
R
D
L
P
L
P
E
V
A
D
L
R
N
V
V
E
G
D
P
S
P
D
G
K
G
T
L
V
I
K
R
G
I
E
V
G
H
I
F
Q
L
G
T
K
Y
S
E
A
M
K
L
S
V
L
S
E
Q
G
K
P
V
N
L
I
M
G
C
Y
G
I
G
V
S
R
V
V
A
A
A
I
E
Q
N
H
D
E
R
G
I
L
W
P
S
A
L
A
P
F
Q
I
A
L
V
P
L
K
Y
E
T
-
E
--
S
V
K
Q
A
T
D
K
L
Y
A
E
L
T
A
A
G
F
E
V
L
L
D
D
R
D
K
KT
S
--
P
G
V
K
F
A
D
M
E
L
I
G
I
P
H
R
I
V
I
S
D
R
G
L
S
E
G
V
L
E
Y
K
G
R
R
D
S
E
S
Q
N
L
P
I
G
E
L
M
S
----
F
I
T
-----------------------------------------------------------------------------------------------
51
Fugue
77.33
47%
-21
- C1 -
-
2J3L
1
SYP_ENTFA
A:
[1-565]
-
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
K
K
-
S
H
E
T
Q
L
-
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
------
D
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
L
G
-
A
D
F
L
D
E
A
T
E
E
D
A
-
R
-
R
V
L
G
A
G
F
G
S
I
G
P
V
N
V
-
S
E
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
-
V
K
-
D
-
E
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
D
-
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
I
L
M--------------------------------------------------------------------------------------------
23
PsiBlast_CBE
76.60
48%
-20
- C1 -
-
2J3L
1
SYP_ENTFA
B:
[1-562]
-
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
-
K
-
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
--
I
A
D
E
E
---
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
-
K
N
F
L
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
-
V
L
-
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
-
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
-
E
-
Y
Q
T
-
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
D
-
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
-----------------------------------------------------------------------------------------------
22
PsiBlast_CBE
76.55
48%
-18
- C1 -
-
2J3M
2
SYP_ENTFA
B:
[1-562]
-
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
-
K
-
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
--
I
A
D
E
E
---
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
-
K
N
F
L
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
-
V
L
-
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
-
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
-
E
-
Y
Q
T
-
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
D
-
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
-----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.39
48%
-19
- C1 -
-
2J3L
1
SYP_ENTFA
A:
[1-562]
-
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
-
K
-
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
--
I
A
D
E
E
---
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
-
K
N
F
L
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
-
V
L
-
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
-
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
-
E
-
Y
Q
T
-
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
D
-
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
-----------------------------------------------------------------------------------------------
63
HHSearch
76.23
48%
-22
- C1 -
-
2J3L
1
SYP_ENTFA
B:
[1-562]
-
M
K
Q
S
K
M
L
I
P
T
L
R
E
V
P
N
D
A
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
G
A
M
G
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
-
K
K
S
H
E
T
Q
L
-
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
D
------
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
L
G
A
D
-
F
L
D
E
A
T
E
E
D
A
R
R
-
V
L
-
G
A
G
F
G
S
I
G
P
V
N
V
S
E
-
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
-
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
-----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.55
48%
-18
- C1 -
-
2J3M
2
SYP_ENTFA
A:
[1-562]
-
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
----
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
-
K
-
K
S
H
E
T
Q
L
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
--
I
A
D
E
E
---
P
V
M
V
L
-
V
R
G
D
H
D
V
N
D
V
K
L
-
K
N
F
L
G
A
D
F
L
D
E
A
T
E
E
D
A
R
R
-
V
L
-
G
A
G
F
G
S
I
G
P
V
N
V
S
E
D
-
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
-
E
-
Y
Q
T
-
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
D
-
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
-----------------------------------------------------------------------------------------------
62
HHSearch
75.28
48%
-20
- C1 -
-
2J3M
2
SYP_ENTFA
A:
[1-562]
-
M
K
Q
S
K
M
L
I
P
T
L
-------
E
V
L
S
H
Q
I
L
L
R
A
G
Y
--------------
I
R
--
Q
-
V
A
A
G
I
Y
S
Y
L
P
L
A
N
R
V
L
E
K
L
K
T
I
M
R
E
E
F
E
K
I
D
A
V
E
M
L
M
P
A
L
L
P
A
E
L
W
K
E
-
S
G
R
Y
E
T
Y
G
P
N
L
Y
R
L
K
----
D
R
----
N
D
R
D
Y
I
L
G
P
T
H
E
E
T
F
T
E
L
I
R
D
E
I
N
S
Y
K
R
L
P
L
N
L
Y
Q
I
Q
T
K
Y
R
D
E
K
R
S
R
S
G
L
L
R
G
R
E
F
-
I
M
-
K
D
G
Y
S
F
H
A
D
E
A
S
L
D
Q
S
Y
R
D
Y
E
K
A
Y
S
R
I
F
E
R
C
G
L
E
F
R
A
I
I
G
D
G
----
G
K
D
S
K
E
F
M
A
I
S
E
I
G
E
D
T
I
C
Y
S
T
E
S
D
Y
A
A
N
L
E
M
A
T
S
L
-
Y
T
P
-
K
K
S
H
E
T
Q
L
-
D
L
E
K
I
A
T
P
E
V
G
T
I
A
E
V
A
N
F
F
E
V
E
P
Q
R
I
I
K
S
V
L
F
I
A
D
------
E
E
P
V
M
V
L
V
R
G
D
H
D
V
N
D
V
K
L
K
N
F
L
G
A
D
-
F
L
D
E
A
T
E
E
D
A
R
R
-
V
L
-
G
A
G
F
G
S
I
G
P
V
N
V
S
E
-
D
V
K
I
Y
A
D
L
A
V
Q
D
L
A
N
A
I
V
G
A
N
E
D
G
Y
H
L
T
N
V
N
P
D
R
D
F
Q
P
I
S
Y
E
D
L
R
F
V
Q
E
G
D
P
S
P
D
G
N
G
V
L
A
F
T
K
G
I
E
I
G
H
I
F
K
L
G
T
R
Y
S
D
A
M
G
A
T
V
L
D
E
N
G
R
E
K
S
V
I
M
G
C
Y
G
I
G
V
S
R
L
L
S
A
I
V
E
Q
N
A
D
E
R
G
I
N
W
P
T
G
I
A
P
F
D
L
H
V
V
Q
M
N
V
K
D
-
E
--
Y
Q
T
K
L
S
Q
E
V
E
A
M
M
T
E
A
G
Y
E
V
L
V
D
D
R
N
E
--
R
--
A
G
V
K
F
A
D
A
D
L
I
G
C
P
I
R
I
T
V
G
K
K
A
V
-
D
G
V
V
E
V
K
I
K
R
T
G
E
M
L
E
V
R
K
E
E
L
E
S
----
T
L
S
-----------------------------------------------------------------------------------------------
65
HHSearch
73.99
46%
-95
- C1 -
-
2I4L
-
SYP_RHOPA
C:
[1-438]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
Y
I
D
R
D
V
L
N
L
P
V
---------------------------------
P
D
E
N
V
D
Y
D
G
D
----
L
T
---------------------------
P
I
I
K
Q
W
T
S
V
Y
A
A
T
------------------------------------------------------
E
D
V
H
E
P
------------------
A
R
Y
E
S
E
V
P
E
A
--
N
R
L
N
T
R
G
I
E
V
G
Q
I
F
Y
F
G
T
K
Y
S
D
S
M
K
A
N
V
T
G
P
D
G
T
D
A
P
I
H
G
G
S
Y
G
V
G
V
S
R
L
L
G
A
I
I
E
A
C
H
D
D
N
G
I
I
W
P
E
A
V
A
P
F
R
V
T
I
L
N
L
K
Q
G
D
-
A
--
A
T
D
A
A
C
D
Q
L
Y
R
E
L
S
A
K
G
V
D
V
L
Y
D
D
T
D
Q
--
R
--
A
G
A
K
F
A
T
A
D
L
I
G
I
P
W
Q
I
H
V
G
P
R
G
L
A
E
G
K
V
E
L
K
R
R
S
D
G
A
R
E
N
L
A
L
A
D
V
V
A
----
R
L
T
-----------------------------------------------------------------------------------------------
64
HHSearch
72.70
46%
-95
- C1 -
-
2I4N
1
SYP_RHOPA
C:
[21-458]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
Y
I
D
R
D
V
L
N
L
P
V
---------------------------------
P
D
E
N
V
D
Y
D
G
D
----
L
T
---------------------------
P
I
I
K
Q
W
T
S
V
Y
A
A
T
------------------------------------------------------
E
D
V
H
E
P
------------------
A
R
Y
E
S
E
V
P
E
A
--
N
R
L
N
T
R
G
I
E
V
G
Q
I
F
Y
F
G
T
K
Y
S
D
S
M
K
A
N
V
T
G
P
D
G
T
D
A
P
I
H
G
G
S
Y
G
V
G
V
S
R
L
L
G
A
I
I
E
A
C
H
D
D
N
G
I
I
W
P
E
A
V
A
P
F
R
V
T
I
L
N
L
K
Q
G
D
-
A
--
A
T
D
A
A
C
D
Q
L
Y
R
E
L
S
A
K
G
V
D
V
L
Y
D
D
T
D
Q
--
R
--
A
G
A
K
F
A
T
A
D
L
I
G
I
P
W
Q
I
H
V
G
P
R
G
L
A
E
G
K
V
E
L
K
R
R
S
D
G
A
R
E
N
L
A
L
A
D
V
V
A
----
R
L
T
-----------------------------------------------------------------------------------------------
53
Fugue
53.88
26%
-8
- C1 -
-
1HC7
-
SYP_THET8
A:
[5-477]
---------
K
G
L
T
P
Q
S
Q
D
F
S
E
W
Y
L
E
V
I
Q
K
A
E
L
--------------
A
D
--
Y
G
P
V
R
G
T
I
V
V
R
P
Y
G
Y
A
I
W
E
N
I
Q
Q
V
L
D
R
M
F
K
E
T
G
H
Q
N
A
Y
F
P
L
F
I
P
M
S
F
L
F
S
-
P
E
L
A
V
V
T
H
A
G
----
G
----
E
E
----
L
E
E
P
L
A
V
R
P
T
S
E
T
V
I
G
Y
M
W
S
K
W
I
R
S
W
R
D
L
P
Q
L
L
N
Q
W
G
N
V
V
R
W
E
M
R
T
R
-
P
F
L
R
T
S
E
F
-
L
W
-
Q
E
G
H
T
A
H
A
T
R
E
E
A
E
E
E
V
R
R
M
L
S
I
Y
A
R
L
A
R
E
Y
A
----------------------------------------------
A
I
P
V
-
I
E
G
-
L
-
K
T
E
K
E
K
-------------------
F
A
G
A
V
Y
T
T
T
I
E
A
L
M
-------------------------------------------------------------------------------------------------------------------------
K
D
G
K
-------
A
L
Q
A
G
T
S
H
Y
L
G
E
N
F
A
R
A
F
D
I
K
F
Q
D
R
D
L
Q
V
K
Y
V
H
T
T
S
W
G
L
S
-
W
R
F
I
G
A
I
I
M
T
H
G
D
D
R
G
L
V
L
P
P
R
L
A
P
I
Q
V
V
I
V
P
I
Y
K
D
E
S
R
-
E
R
V
L
E
A
A
Q
G
L
R
Q
A
L
L
A
Q
G
L
R
V
H
L
D
D
R
D
Q
--
H
T-
P
G
Y
K
F
H
E
W
E
L
K
G
V
P
F
R
V
E
L
G
P
K
D
L
E
G
G
Q
A
V
L
A
S
R
L
G
-
G
K
E
T
L
P
L
A
A
L
P
E
----
A
L
P
G
K
L
D
A
F
H
E
E
L
Y
R
R
A
L
A
F
R
E
D
H
T
R
K
V
DT
Y
E
A
F
K
E
A
V
Q
E
G
F
A
L
A
F
H
CGD
K
A
C
E
R
L
I
Q
E
E
TTATTRCVPFEAE
P
E
E
G
F
CVRCGRPSAYG
K
R
V
V
F
A
KAY
52
Fugue
51.23
26%
29
* C1 *
-
1NJ8
-
SYP_METJA
A:
[0-455]
M
L
E
F
S
E
W
Y
S
D
I
L
E
K
----
A
E
I
Y
D
V
-----------------------
R
--
Y
-
P
I
K
G
C
G
V
Y
L
P
Y
G
F
K
I
R
R
Y
T
F
E
I
I
R
N
L
L
D
E
S
G
H
D
E
A
L
F
P
M
L
I
P
E
D
L
L
A
K
E
A
E
H
I
K
G
F
E
D
E
V
Y
W
V
T
HGGK
T
Q
----
L
D
V
K
L
A
L
R
P
T
S
E
T
P
I
Y
Y
M
M
K
L
W
V
K
V
H
T
D
L
P
I
K
I
Y
Q
I
V
N
T
F
R
Y
E
T
K
H
T
R
P
L
I
R
L
R
E
I
M
T
F
-
K
E
A
H
T
A
H
S
T
K
E
E
A
E
N
Q
V
K
E
A
I
S
I
Y
K
K
F
F
D
T
L
G
I
-----------------------------------------------
P
Y
-
L
I
S
-
K
-
R
P
E
W
D
K
-
F
------------------------------------------------------------------------------------------------------------------------------------
P
G
A
E
Y
T
M
A
F
D
T
I
-------
F
P
D
G
R
-------
T
M
Q
I
A
T
V
H
N
L
G
Q
N
F
S
K
T
F
E
I
I
F
E
T
P
T
G
D
K
D
Y
A
Y
Q
T
C
Y
G
I
S
-
D
R
V
I
A
S
I
I
A
I
H
G
D
E
K
G
L
I
L
P
P
I
V
A
P
I
Q
V
V
I
V
P
L
I
F
K
G
-
K
-
E
D
I
V
M
E
K
A
K
E
I
Y
E
K
L
K
G
K
F
R
V
H
I
D
D
R
D
I
--
R
--
P
G
R
K
F
N
D
W
E
I
K
G
V
P
L
R
I
E
V
G
P
K
D
I
E
N
K
K
I
T
L
F
R
R
D
T
M
E
K
F
Q
V
D
E
T
Q
L
M
E
----
V
V
E
K
T
L
N
N
I
M
E
N
I
K
N
R
A
W
E
K
F
E
N
F
I
T
I
L
EDIN
P
D
E
I
K
N
I
L
S
E
KRG
V
I
L
V
PFKEEIYN
E
E
L
E
E
K
VEATIL
G
E
T
E
Y
K
G
N
K
Y
I
A
I
A
K
T
Y------------
67
HHSearch
51.17
25%
-7
- C1 -
-
1NJ1
1
SYP_METTH
A:
[39-409]
-------------------------------
E
F
S
E
W
F
H
N
I
L
E
E
A
EI
I
D
QR
Y
-
P
V
K
G
M
H
V
W
M
P
H
G
F
M
I
R
K
N
T
L
K
I
L
R
R
I
L
-
D
R
D
H
E
E
V
L
F
P
L
L
V
P
E
D
E
L
A
K
E
A
I
H
V
K
G
F
E
D
E
V
Y
W
V
T
----
H
G
GLSK
L
Q
R
K
L
A
L
R
P
T
S
E
T
V
M
Y
P
M
F
A
L
W
V
R
S
H
T
D
L
P
M
R
F
Y
Q
V
V
N
T
F
R
Y
E
T
K
H
T
R
P
L
I
R
V
R
E
I
-
T
T
F
K
E
A
H
T
I
H
A
T
A
S
E
A
E
E
Q
V
E
R
A
V
E
I
Y
K
E
F
F
N
S
L
G
I
P
Y
L
I
T
R
R
---
P
------------------------------
P
W
D
K
------------------------------------
F
P
G
S
-----------------------------------------------
E
Y
T
-------------------------------
V
-------------------
A
-----------
F
D
---
T
----------
L
M
P
-------
D
G
K
T
L
Q
I
G
T
V
H
N
L
G
Q
T
F
A
R
T
F
E
I
K
F
E
T
P
E
G
D
H
E
Y
V
H
Q
T
C
Y
G
L
S
-
D
R
V
I
A
S
V
I
A
I
H
G
D
E
S
G
L
C
L
P
P
D
V
A
A
H
Q
V
V
I
V
P
I
I
F
K
K
-
A
A
E
E
V
M
E
A
C
R
E
L
R
S
R
L
E
A
A
G
F
R
V
H
L
D
D
R
D
I
--
R
--
A
G
R
K
Y
Y
E
W
E
M
R
G
V
P
L
R
V
E
I
G
P
R
D
L
E
K
G
A
A
V
I
S
R
R
D
T
G
E
K
V
T
A
D
L
Q
G
I
E
E
----
T
L
R
-----------------------------------------------------------------------------------------------
28
PsiBlast_CBE
51.09
57%
-81
- C2 -
-
2I4M
1
SYP_RHOPA
C:
[21-241]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
51.06
25%
-7
- C1 -
-
1NJ5
1
SYP_METTH
A:
[39-409]
-------------------------------
E
F
S
E
W
F
H
N
I
L
E
E
A
EI
I
D
QR
Y
-
P
V
K
G
M
H
V
W
M
P
H
G
F
M
I
R
K
N
T
L
K
I
L
R
R
I
L
-
D
R
D
H
E
E
V
L
F
P
L
L
V
P
E
D
E
L
A
K
E
A
I
H
V
K
G
F
E
D
E
V
Y
W
V
T
----
H
G
GLSK
L
Q
R
K
L
A
L
R
P
T
S
E
T
V
M
Y
P
M
F
A
L
W
V
R
S
H
T
D
L
P
M
R
F
Y
Q
V
V
N
T
F
R
Y
E
T
K
H
T
R
P
L
I
R
V
R
E
I
-
T
T
F
K
E
A
H
T
I
H
A
T
A
S
E
A
E
E
Q
V
E
R
A
V
E
I
Y
K
E
F
F
N
S
L
G
I
P
Y
L
I
T
R
R
---
P
------------------------------
P
W
D
K
------------------------------------
F
P
G
S
-----------------------------------------------
E
Y
T
-------------------------------
V
-------------------
A
-----------
F
D
---
T
----------
L
M
P
-------
D
G
K
T
L
Q
I
G
T
V
H
N
L
G
Q
T
F
A
R
T
F
E
I
K
F
E
T
P
E
G
D
H
E
Y
V
H
Q
T
C
Y
G
L
S
-
D
R
V
I
A
S
V
I
A
I
H
G
D
E
S
G
L
C
L
P
P
D
V
A
A
H
Q
V
V
I
V
P
I
I
F
K
K
-
A
A
E
E
V
M
E
A
C
R
E
L
R
S
R
L
E
A
A
G
F
R
V
H
L
D
D
R
D
I
--
R
--
A
G
R
K
Y
Y
E
W
E
M
R
G
V
P
L
R
V
E
I
G
P
R
D
L
E
K
G
A
A
V
I
S
R
R
D
T
G
E
K
V
T
A
D
L
Q
G
I
E
E
----
T
L
R
-----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
50.70
57%
-86
- C2 -
-
2I4O
2
SYP_RHOPA
C:
[21-241]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.37
57%
-87
- C2 -
-
2I4O
1
SYP_RHOPA
A:
[21-241]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.32
57%
-88
- C2 -
-
2I4M
-
SYP_RHOPA
A:
[21-241]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
50.23
57%
-88
- C2 -
-
2I4L
-
SYP_RHOPA
A:
[1-221]
-
M
R
L
S
R
F
F
L
P
I
L
K
E
N
P
K
E
A
E
I
V
S
H
R
L
M
L
R
A
G
M
--------------
L
R
--
Q
-
E
A
A
G
I
Y
A
W
L
P
L
G
H
R
V
L
K
K
I
E
Q
I
V
R
E
E
Q
N
R
A
G
A
I
E
L
L
M
P
T
L
Q
L
A
D
L
W
R
E
-
S
G
R
Y
D
A
Y
G
P
E
M
L
R
I
A
----
D
R
----
H
K
R
E
L
L
Y
G
P
T
N
E
E
M
I
T
E
I
F
R
A
Y
I
K
S
Y
K
S
L
P
L
N
L
Y
H
I
Q
W
K
F
R
D
E
Q
R
P
R
F
G
V
M
R
G
R
E
F
-
L
M
-
K
D
A
Y
S
F
D
V
D
E
A
G
A
R
K
S
Y
N
K
M
F
V
A
Y
L
R
T
F
A
R
M
G
L
K
A
I
P
M
R
A
E
T
G
P
I
G
G
D
L
S
H
E
F
I
V
L
A
E
T
G
E
S
G
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------