@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS33: (2017-12-05 )
MPHSLVESLSGCLEFHLNYQQTKVNQHVLNINQTWSISMNLPTTMKIVEITVPGGPEVLKLQDSNVPVPQADEALIEVKAAGINRPDVLQRMGLYPMPKGVTQIPGLEVAGVVVAVGEQVQQFKVGDKVCALTNGGGYAEYCAVTATQVLPIPENLSFTQAAAIPETFFTVWANLFDIGRLKKDETALIHGGASGIGTTALAICHALGIKTFATVGSEDKVEALSDLTTAINYKTQDFEQEILNHTQEQGVDVILDIVGGSYFQKNLNLLKRDGRLVIIGFMGGRIGKEFDLQKLILKCATITGSTMRARNSQEKAQIAQSLHEHVWPLLAQGKCLPQIYKTYAFSDVQSAHACMEQGDHIGKIVLEMNA
Atome Classification :
(20 SA)
.........10........20........30........40........50..-----------......60-.-.......70........80........90..----------------....-.---------------.100.......110.......120........-130-...----------------------------..------------------------....140.....-..150.......160.......170....---.--..180.......190.......200.......210.......--220......--.--230.........------------------240.......250.......260.......270.......280.......290.......300.......310------------........320.......330--..--......340.......350.......-360.......370
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
P
H
S
L
V
E
S
L
S
G
C
L
E
F
HLN
Y
Q
QTKVN
Q
H
V
L
NIN
Q
T
W
S
I
S
MNLP
T
T
M
K
I
V
E
I
TVP-----------GG
P
E
V
L
K
L-Q-DSNVPVPQADE
A
L
I
E
V
K
AAGIN
R
P
D
V
L
Q
R
MG----------------LYPM-P---------------KGVTQIPGL
E
V
A
G
V
V
V
A
V
G
E
Q
V
Q
-
Q
FKVGD
K
V
-
C
---
A
L
T----------------------------NG------------------------GG
Y
A
E
Y
C
A
V
T
A
T
-
Q
V
LPIPENLSF
T
Q
AAAI
P
E
T
F
F
T
V
W
A
N
L
F
---
D
--
I
GRLKKDE
T
A
L
I
HGGASG
I
G
T
T
A
L
A
I
C
H
A
LGIK
T
F
ATVGS
E
D
--
K
V
E
A
L
S
D
L
T
--
T
--
A
--INYKT
Q
D
F
E
------------------
Q
E
I
L
N
H
T
Q
EQG
V
D
V
I
L
D
I
VG
G
S
Y
F
Q
K
N
L
N
L
L
KRDG
R
L
V
I
I
G
FMGGRIGKEF
D
L
Q
K
L
I
L
K
C
ATITGSTMRARN-------------
S
Q
E
K
A
Q
I
A
Q
S
L
H
E
H
V
W
P
L
L
A---QG--
K
C
L
P
Q
I
Y
K
T
Y
AF
S
D
V
Q
S
A
H
A
C
M
E
QGD-H
I
G
K
I
V
L
E
MNA
42
HHSearch
82.81
48%
-84
- C1 -
-
4DUP
-
?
B:
[3-331]
----------------------------------------
L
P
Q
E
M
R
F
V
D
L
K
S
F
-----------
G
G
P
D
V
M
V
I
-
G
-
K
R
P
L
P
V
A
G
E
G
E
V
L
V
R
A
E
A
I
G
V
N
R
P
D
I
A
Q
R
Q
G
----------------
S
Y
P
P
-
P
---------------
K
D
A
S
P
I
L
G
L
E
L
S
G
E
I
V
G
V
G
P
-----
Y
A
V
G
D
K
V
-
C
---
G
L
A
----------------------------
N
G
------------------------
G
A
Y
A
E
Y
C
L
L
P
A
G
-
Q
I
L
P
F
P
K
G
Y
D
A
V
K
A
A
A
L
P
E
T
F
F
T
V
W
A
N
L
F
---
Q
--
M
A
G
L
T
E
G
E
S
V
L
I
H
G
G
T
S
G
I
G
T
T
A
I
Q
L
A
R
A
F
G
A
E
V
Y
A
T
A
---------
A
C
E
R
L
G
AK
R
--
G
--
I
N
Y
R
S
E
D
F
A
------------------
A
V
I
K
A
E
T
-
G
Q
G
V
D
I
I
L
D
M
I
G
A
A
Y
F
E
R
N
I
A
S
L
A
K
D
G
C
L
S
I
I
A
F
L
G
G
A
V
A
E
K
V
N
L
S
P
I
M
V
K
R
L
T
V
T
G
S
T
M
R
P
R
T
-------------
A
E
E
K
R
A
I
R
D
D
L
L
S
E
V
W
P
L
L
E
---
A
G
--
T
V
A
P
V
I
H
K
V
F
A
F
E
D
V
A
D
A
H
R
L
L
E
-------
K
V
M
L
T
V
--
55
HHSearch
75.49
37%
-58
- C1 -
-
2J8Z
1
QORX_HUMAN
A:
[21-354]
------------------------------------------
Q
S
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
-
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
AA
A
--
G
--
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T----Q-
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
P
Q
2
PsiBlast_PDB
74.93
38%
-62
- C1 -
-
2J8Z
1
QORX_HUMAN
A:
[22-352]
-------------------------------------------
S
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
-
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
--
A
--
A
A
G
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T----Q-
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
--
22
PsiBlast_CBE
72.98
38%
-43
- C1 -
-
2OBY
1
QORX_HUMAN
D:
[7-336]
--------------------------------------------
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
--
A
--
A
AG
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T--
E
G
PQ
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
--
3
PsiBlast_PDB
72.60
38%
-42
- C1 -
-
2OBY
1
QORX_HUMAN
A:
[7-336]
--------------------------------------------
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
--
A
--
A
AG
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T--
E
G
PQ
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
--
21
PsiBlast_CBE
72.41
38%
-40
- C1 -
-
2OBY
1
QORX_HUMAN
E:
[7-336]
--------------------------------------------
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
--
A
--
A
AG
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T--
E
G
PQ
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
--
24
PsiBlast_CBE
72.33
38%
-46
- C1 -
-
2OBY
1
QORX_HUMAN
B:
[7-336]
--------------------------------------------
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
--
A
--
A
AG
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T--
E
G
PQ
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
--
47
HHSearch
71.37
25%
-30
- C1 -
-
4A0S
4
?
C:
[19-414]
--------------------------------------
A
P
V
P
D
T
Y
L
A
L
H
L
R
A
E
DADMFKGVADK
D
V
R
K
S
L
R
L
-
G
-
E
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
F
EPIPTFHFLKQNARQG
G
W
A
T
R
H
---------------
D
Q
P
Y
H
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
G
V
R
-
R
W
K
P
G
D
H
V
-
I
---
V
H
P
AHVDEQEPATHGDGMLGTEQRAWGFET-
N
F
------------------------
G
G
L
A
E
Y
G
V
V
R
A
S
-
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
---
S
DR
G
A
Q
M
K
Q
G
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
I
P
V
A
V
V
S
S
A
Q
--
K
E
A
A
V
R
A
L
G
CD
L
--
V
--
I
N
R
A
E
L
G
I
T
DDIADDPRRVVETGRKLA
K
L
V
V
-
E
K
A
G
R
E
P
D
I
V
F
E
H
T
G
R
V
T
F
G
L
S
V
I
V
A
R
R
G
G
T
V
V
T
C
G
S
S
S
G
Y
L
H
-
T
F
D
N
R
Y
L
W
M
K
L
K
K
I
V
G
S
H
G
A
N
-----------------------
H
E
E
Q
Q
A
T
N
R
L
F
E
---
S
G
--
A
V
V
P
A
M
S
A
V
Y
P
L
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
V
G
K
V
A
V
L
C
M
-
23
PsiBlast_CBE
71.05
38%
-43
- C1 -
-
2OBY
1
QORX_HUMAN
C:
[7-336]
--------------------------------------------
M
L
A
V
H
F
D
K
P
-----------
G
G
P
E
N
L
Y
V
-
K
-
E
V
A
K
P
S
P
G
E
G
E
V
L
L
K
V
A
A
S
A
L
N
R
A
D
L
M
Q
R
Q
G
----------------
Q
Y
D
P
-
P
---------------
P
G
A
S
N
I
L
G
L
E
A
S
G
H
V
A
E
L
G
P
G
C
Q
G
H
W
K
I
G
D
T
A
-
M
---
A
L
L
----------------------------
P
G
------------------------
G
G
Q
A
Q
Y
V
T
V
P
E
G
-
L
L
M
P
I
P
E
G
L
T
L
T
Q
A
A
A
I
P
E
A
W
L
T
A
F
Q
L
L
H
---
L
--
V
G
N
V
Q
A
G
D
Y
V
L
I
H
A
G
L
S
G
V
G
T
A
A
I
Q
L
T
R
M
A
G
A
I
P
L
V
T
A
G
S
Q
K
--
K
L
Q
M
A
E
K
L
G
--
A
--
A
AG
F
N
Y
K
K
E
D
F
S
------------------
E
A
T
L
K
F
T
K
G
A
G
V
N
L
I
L
D
C
I
G
G
S
Y
W
E
K
N
V
N
C
L
A
L
D
G
R
W
V
L
Y
G
L
M
G
G
G
D
I
N
G
P
L
F
S
K
L
L
F
K
R
G
S
L
I
T
S
L
L
R
S
R
D
-------------
N
K
Y
K
Q
M
L
V
N
A
F
T
E
Q
I
L
P
H
F
S
T--
E
G
PQ
R
L
L
P
V
L
D
R
I
Y
P
V
T
E
I
Q
E
A
H
K
Y
M
E
A
N
K
-
N
I
G
K
I
V
L
E
L
--
48
HHSearch
70.33
25%
-32
- C1 -
-
4A0S
4
?
B:
[19-414]
--------------------------------------
A
P
V
P
D
T
Y
L
A
L
H
L
R
A
E
DADMFKGVADK
D
V
R
K
S
L
R
L
-
G
-
E
V
P
M
P
E
L
A
P
D
E
V
L
V
A
V
M
A
S
S
I
N
Y
N
T
V
W
S
A
M
F
EPIPTFHFLKQNARQG
G
W
A
T
R
H
---------------
D
Q
P
Y
H
V
L
G
S
D
C
S
G
V
V
V
R
T
G
I
G
V
R
-
R
W
K
P
G
D
H
V
-
I
---
V
H
P
AHVDEQEPATHGDGMLGTEQRAWGFET-
N
F
------------------------
G
G
L
A
E
Y
G
V
V
R
A
S
-
Q
L
L
P
K
P
A
H
L
T
W
E
E
A
A
V
S
P
L
C
A
G
T
A
Y
R
M
L
V
---
S
DR
G
A
Q
M
K
Q
G
D
I
V
L
I
W
G
A
S
G
G
L
G
S
Y
A
I
Q
F
V
K
N
G
G
G
I
P
V
A
V
V
S
S
A
Q
--
K
E
A
A
V
R
A
L
G
CD
L
--
V
--
I
N
R
A
E
L
G
I
T
DDIADDPRRVVETGRKLA
K
L
V
V
-
E
K
A
G
R
E
P
D
I
V
F
E
H
T
G
R
V
T
F
G
L
S
V
I
V
A
R
R
G
G
T
V
V
T
C
G
S
S
S
G
Y
L
H
-
T
F
D
N
R
Y
L
W
M
K
L
K
K
I
V
G
S
H
G
A
N
-----------------------
H
E
E
Q
Q
A
T
N
R
L
F
E
---
S
G
--
A
V
V
P
A
M
S
A
V
Y
P
L
A
E
A
A
E
A
C
R
V
V
Q
T
S
R
-
Q
V
G
K
V
A
V
L
C
M
-
53
HHSearch
69.94
29%
-11
- C1 -
-
4J6F
2
?
B:
[26-382]
------------------------------------
M
M
H
S
V
P
K
T
M
T
A
V
L
L
T
G
H
-----------
G
G
L
E
K
L
V
Y
S
R
-
D
V
P
V
P
A
P
A
A
G
E
V
L
I
K
V
T
A
C
G
M
N
N
T
D
V
W
V
R
E
G
----------------
A
Y
G
T
-
E
DDPSAVSTWRRHGNT
L
T
F
P
R
I
Q
G
T
D
T
V
G
H
I
V
A
V
G
E
G
V
D
-
R
A
R
I
G
E
R
V
-
M
---
V
D
F
SIYNRDDDSLAD
I
D
Y
M
GHG---------
R
D
------------------------
G
G
Y
A
E
Y
M
A
L
P
A
E
-
N
A
H
V
V
A
T
D
L
T
D
I
E
L
A
T
F
C
C
A
Y
L
T
G
E
R
M
L
E
------
R
A
R
L
A
A
G
E
T
V
L
V
T
G
A
S
G
G
V
G
S
A
I
I
Q
L
A
R
A
R
G
A
V
P
I
A
V
A
G
P
G
---
K
E
A
A
M
L
D
I
G
AQ
A
--
V
--
V
T
R
G
Q
G
D
L
A
------------------
E
A
V
E
A
A
S
G
G
R
P
I
D
V
V
A
D
L
V
G
G
P
L
F
N
D
L
L
K
I
L
R
P
E
G
R
Y
T
T
A
G
A
I
A
G
P
V
V
-
Q
L
D
L
R
T
M
Y
L
K
Q
L
E
L
H
G
S
S
Q
G
S
-----------------------
R
A
D
F
R
R
L
V
R
Y
I
E
---
E
K
--
K
I
R
P
L
V
G
G
V
Y
P
L
S
E
F
H
R
A
Q
T
D
F
M
A
K
N
-
F
V
G
K
L
V
V
V
P
D
-
6
PsiBlast_PDB
69.47
28%
-20
- C1 -
-
2EIH
-
?
A:
[1-343]
--------------------------------------------
M
R
A
V
V
M
R
A
R
-----------
G
G
P
E
V
L
E
V
-
A
-
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
----------------
V
A
S
P
-
K
---------------
L
P
L
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
-
G
F
A
P
G
D
E
V
-
V
I
NP
G
L
S
----------------------------
C
G
RC
E
R
C
L
A
GEDNLCPRYQILGEHRH
G
T
Y
A
E
Y
V
V
L
P
E
A
-
N
L
A
P
K
P
K
N
L
S
F
E
E
A
A
A
I
P
L
T
F
L
T
A
W
Q
M
V
V
---
D
--
K
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
R
V
I
A
T
A
G
S
E
D
--
K
L
R
R
A
K
A
L
G
--
A
D
E
T
--
V
N
Y
T
H
P
D
W
P
------------------
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
Y
F
E
G
V
I
K
A
T
A
N
G
G
R
I
A
I
A
G
A
S
S
G
Y
E
G
T
-
L
P
F
A
H
V
F
Y
R
Q
L
S
I
L
G
S
T
M
A
S
K
S
--------------------------
R
L
F
P
I
L
R
F
V
E
E
G
--
K
L
K
P
V
V
G
Q
V
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
R
-
V
F
G
K
V
V
L
Q
V
G
-
54
HHSearch
68.95
29%
-11
- C1 -
-
4J6F
2
?
A:
[26-382]
------------------------------------
M
M
H
S
V
P
K
T
M
T
A
V
L
L
T
G
H
-----------
G
G
L
E
K
L
V
Y
S
R
-
D
V
P
V
P
A
P
A
A
G
E
V
L
I
K
V
T
A
C
G
M
N
N
T
D
V
W
V
R
E
G
----------------
A
Y
G
T
-
E
DDPSAVSTWRRHGNT
L
T
F
P
R
I
Q
G
T
D
T
V
G
H
I
V
A
V
G
E
G
V
D
-
R
A
R
I
G
E
R
V
-
M
---
V
D
F
SIYNRDDDSLAD
I
D
Y
M
GHG---------
R
D
------------------------
G
G
Y
A
E
Y
M
A
L
P
A
E
-
N
A
H
V
V
A
T
D
L
T
D
I
E
L
A
T
F
C
C
A
Y
L
T
G
E
R
M
L
E
------
R
A
R
L
A
A
G
E
T
V
L
V
T
G
A
S
G
G
V
G
S
A
I
I
Q
L
A
R
A
R
G
A
V
P
I
A
V
A
G
P
G
---
K
E
A
A
M
L
D
I
G
AQ
A
--
V
--
V
T
R
G
Q
G
D
L
A
------------------
E
A
V
E
A
A
S
G
G
R
P
I
D
V
V
A
D
L
V
G
G
P
L
F
N
D
L
L
K
I
L
R
P
E
G
R
Y
T
T
A
G
A
I
A
G
P
V
V
-
Q
L
D
L
R
T
M
Y
L
K
Q
L
E
L
H
G
S
S
Q
G
S
-----------------------
R
A
D
F
R
R
L
V
R
Y
I
E
---
E
K
--
K
I
R
P
L
V
G
G
V
Y
P
L
S
E
F
H
R
A
Q
T
D
F
M
A
K
N
-
F
V
G
K
L
V
V
V
P
D
-
51
HHSearch
67.46
29%
-69
- C1 -
-
4EYE
1
?
A:
[18-342]
----------------------------------------
G
P
G
S
M
K
A
I
Q
A
Q
S
L
-----------
S
G
P
E
G
L
V
Y
-
T
-
D
V
E
T
P
G
A
G
P
N
V
V
V
V
D
V
K
A
A
G
V
C
F
P
D
Y
L
M
T
K
G
----------------
E
Y
Q
L
-
K
---------------
M
E
P
P
F
V
P
G
I
E
T
A
G
V
V
R
S
A
P
E
G
-
S
-
G
I
K
P
G
D
R
V
-
M
---
A
F
N
----------------------------
F
I
------------------------
G
G
Y
A
E
R
V
A
V
A
P
S
-
N
I
L
P
T
P
P
Q
L
D
D
A
E
A
V
A
L
I
A
N
Y
H
T
M
Y
F
A
Y
A
---
R
--
R
G
Q
L
R
A
G
E
T
V
L
V
L
G
A
A
G
G
I
G
T
A
A
I
Q
I
A
K
G
M
G
A
K
V
I
A
V
V
N
R
T
A
--
A
T
E
F
V
K
S
V
G
AD
I
--
V
--
L
P
L
E
-
E
G
W
A
------------------
K
A
V
R
E
A
T
G
G
A
G
V
D
M
V
V
D
P
I
G
--
A
F
D
D
A
V
R
T
L
A
S
E
G
R
L
L
V
V
-----------
K
V
N
R
L
L
L
R
N
A
S
L
I
G
V
A
W
G
E
F
L
-------------
R
T
H
A
-
D
Y
L
Y
E
T
Q
A
G
L
E
K
L
V
A
---
E
G
---
M
R
P
P
V
S
A
R
I
P
L
S
E
G
R
Q
A
L
Q
D
F
A
D
G
K
-
V
Y
G
K
M
V
L
V
P
--
49
HHSearch
67.10
31%
-36
- C1 -
-
1YB5
5
QOR_HUMAN
A:
[28-351]
------------------------------------------
K
L
M
R
A
V
R
V
F
E
F
-----------
G
G
P
E
V
L
K
L
-
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
----------------
T
Y
S
R
-
K
---------------
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
V
G
D
N
A
S
-
A
F
K
K
G
D
R
V
-
F
---
T
S
S
T---------------------------
I
S
------------------------
G
G
Y
A
E
Y
A
L
A
A
D
H
-
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
---
H
--
S
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
K
I
L
G
T
A
G
T
E
E
--
G
Q
K
I
V
L
Q
N
G
AH
E
--
V
--
F
N
H
R
E
V
N
Y
I
------------------
D
K
I
K
K
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
G
T
I
E
---
I
N
P
R
D
T
M
A
K
E
S
S
I
I
G
V
T
L
F
S
S
T
-------------
K
----
E
E
F
Q
Q
Y
A
A
A
L
Q
A
G
M
E
---
I
G
--
W
L
K
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
A
T
G
K
M
I
L
L
L
--
4
PsiBlast_PDB
66.74
32%
-29
- C1 -
-
1YB5
5
QOR_HUMAN
A:
[30-349]
--------------------------------------------
M
R
A
V
R
V
F
E
F
-----------
G
G
P
E
V
L
K
L
-
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
----------------
T
Y
S
R
-
K
---------------
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
V
G
D
N
A
S
-
A
F
K
K
G
D
R
V
F
T
---
S
S
T
----------------------------
I
S
------------------------
G
G
Y
A
E
Y
A
L
A
A
D
H
-
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
---
H
--
S
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
K
I
L
G
T
A
G
T
E
E
G
Q
K
I
V
L
Q
N
G
A
H
--
E
--
V
--
F
N
H
R
E
V
N
Y
I
------------------
D
K
I
K
K
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
G
---
T
I
E
I
N
P
R
D
T
M
A
K
E
S
S
I
I
G
V
T
L
F
S
S
T
-------------
K
E
E
F
Q
Q
Y
A
A
A
L
Q
A
G
----
M
E
---
I
G
--
W
L
K
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
A
T
G
K
M
I
L
----
5
PsiBlast_PDB
66.56
27%
-116
- C1 -
-
4A27
4
VAT1L_HUMAN
A:
[4-342]
--------------------------------------------
M
R
A
V
V
L
A
G
F
-----------
G
G
L
N
K
L
R
L
-
F
-
R
K
A
M
P
E
P
Q
D
G
E
L
K
I
R
V
K
A
C
G
L
N
F
I
D
L
M
V
R
Q
G
----------------
N
I
D
N
-
P
---------------
P
K
T
P
L
V
P
G
F
E
C
S
G
I
V
E
A
L
G
D
S
V
K
-
G
Y
E
I
G
D
R
V
-
M
---
A
F
V
----------------------------
N
Y
------------------------
N
A
W
A
E
V
V
C
T
P
V
E
-
F
V
Y
K
I
P
D
D
M
S
F
S
E
A
A
A
F
P
M
N
F
V
T
A
Y
V
M
L
F
---
E
--
V
A
N
L
R
E
G
M
S
V
L
V
H
S
A
G
G
G
V
G
Q
A
V
A
Q
L
C
S
T
V
P
N
V
T
V
F
G
T
A
S
T
F
--
K
H
E
A
I
K
D
S
V
--
T
--
H
--
L
F
D
R
N
A
D
Y
V
------------------
Q
E
V
-
K
R
I
S
A
E
G
V
D
I
V
L
D
C
L
C
-------
L
S
L
L
K
P
L
G
T
Y
I
L
Y
G
----------------------
N
P
I
K
L
Y
E
E
N
K
V
I
A
G
F
S
L
L
N
L
L
F
K
Q
G
R
A
G
L
I
R
G
V
V
E
K
L
I
G
L
Y
N
---
Q
K
--
K
I
K
P
V
V
D
S
L
W
A
L
E
E
V
K
E
A
M
Q
R
I
H
D
R
G
-
N
I
G
K
L
I
L
D
V
--
25
PsiBlast_CBE
65.84
32%
-30
- C1 -
-
1YB5
3
QOR_HUMAN
B:
[30-349]
--------------------------------------------
M
R
A
V
R
V
F
E
F
-----------
G
G
P
E
V
L
K
L
-
R
S
D
I
A
V
P
I
P
K
D
H
Q
V
L
I
K
V
H
A
C
G
V
N
P
V
E
T
Y
I
R
S
G
----------------
T
Y
S
R
-
K
---------------
P
L
L
P
Y
T
P
G
S
D
V
A
G
V
I
E
A
V
G
D
N
A
S
-
A
F
K
K
G
D
R
V
F
T
---
S
S
T
----------------------------
I
S
------------------------
G
G
Y
A
E
Y
A
L
A
A
D
H
-
T
V
Y
K
L
P
E
K
L
D
F
K
Q
G
A
A
I
G
I
P
Y
F
T
A
Y
R
A
L
I
---
H
--
S
A
C
V
K
A
G
E
S
V
L
V
H
G
A
S
G
G
V
G
L
A
A
C
Q
I
A
R
A
Y
G
L
K
I
L
G
T
A
G
T
E
E
GQ
K
I
V
L
Q
N
G
A
H
--
E
--
V
--
F
N
H
R
E
V
N
Y
I
------------------
D
K
I
K
K
Y
V
G
E
K
G
I
D
I
I
I
E
M
L
A
N
V
N
L
S
K
D
L
S
L
L
S
H
G
G
R
V
I
V
V
G
S
R
G
---
T
I
E
I
N
P
R
D
T
M
A
K
E
S
S
I
I
G
V
T
L
F
S
S
T
-------------
K
E
E
F
Q
Q
Y
A
A
A
L
Q
A
G
----
M
E
---
I
G
--
W
L
K
P
V
I
G
S
Q
Y
P
L
E
K
V
A
E
A
H
E
N
I
I
H
G
S
G
A
T
G
K
M
I
L
----
16
PsiBlast_PDB
63.69
27%
-11
- C1 -
-
3QWB
3
QOR_YEAST
A:
[5-332]
----------------------------------------
I
P
E
Q
Q
K
V
I
L
I
D
E
I
-----------
G
G
Y
D
V
I
K
Y
-
E
-
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
----------------
I
Y
P
C
-
E
---------------
K
--
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
-
N
F
E
V
G
D
Q
V
-
A
---
Y
I
S
----------------------------
N
-------------------------
S
T
F
A
Q
Y
S
K
I
S
S
Q
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
--
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
--
K
L
K
I
A
K
E
Y
G
--
A
--
E
YL
I
N
A
S
K
E
D
I
L
------------------
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
L
I
-
P
P
F
S
I
T
R
L
S
P
K
N
I
T
L
V
R
P
Q
L
Y
G
Y
I
-------------
A
D
P
E
E
W
--
K
Y
Y
S
D
E
F
F
G
L
V
N
---
S
K
--
K
L
N
I
K
I
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
-
T
V
G
K
L
V
L
E
I
--
56
HHSearch
62.21
28%
-14
- C1 -
-
5K1S
-
?
C:
[12-361]
--------------------------------------
L
Y
F
Q
G
H
M
K
A
V
V
L
R
S
F
-----------
G
E
A
G
N
L
K
M
-
E
-
T
M
P
M
P
R
P
G
R
G
E
V
L
L
R
V
H
A
C
G
V
C
Y
H
D
V
I
N
R
R
G
----------------
N
L
P
R
-----------------
T
S
V
P
A
I
L
G
H
E
A
A
G
E
V
I
E
V
G
P
D
T
P
-
G
W
K
T
G
D
R
A
-
A
---
T
L
Q
RMSCGDCALCRSGRNSLCKTDNRFFGEE
L
P
------------------------
G
G
Y
A
Q
F
M
V
A
P
V
G
-
G
L
G
R
V
P
A
S
L
P
W
N
E
A
A
T
V
C
C
T
T
G
T
A
V
H
T
V
R
---
T
--
R
G
K
V
R
A
G
E
T
V
L
I
T
G
A
S
G
G
V
G
L
S
S
V
Q
L
A
R
L
D
G
A
R
V
I
A
V
T
S
S
E
A
--
K
V
Q
A
L
K
E
A
G
AD
E
--
V
--
I
V
S
R
G
L
D
F
A
------------------
S
D
V
R
K
R
T
Q
G
A
G
V
D
V
A
V
E
I
V
G
S
A
T
F
D
Q
T
L
K
S
M
A
P
G
G
R
V
V
V
V
G
N
L
E
S
G
M
V
-
Q
L
N
P
G
L
V
I
V
K
E
L
E
I
L
G
A
Y
A
T
-----------------------
T
Q
A
E
L
D
E
A
L
R
L
T
A
---
T
G
--
G
V
R
Q
F
V
T
D
A
V
P
L
A
E
A
A
K
A
H
F
R
L
E
N
R
E
-
V
A
G
R
L
V
L
V
P
P
E