@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSH9: (2017-12-08 )
MIMIDPKLLRNNIEVVNAALAKRGVQLDVQEWASLETRRKDLQSKTEKLQAERNAGAKQVGQIKKSGGDASEIMARMQAIGDEIKAAEVALSELQNEIEQKALSIPNLPDESVPAGKDENDNVEISKWGTPRQFDFEIKDHTDLGEWMGGLEFETATKLTGSRFSVLKGPLARLQRALTQFMLDTHTLKNGYTEAYVPYLVNADSLRGTGQLPKFEEDLFKLQGEKEYYLIPTAEVPVTNFVRDEIIDADRLPLKYAAHTPCFRSEAGSYGRDTRGLIRQHQFDKVEMVQIVKPETSMQALEELTAHAEGILQALGLPYRKILLCGGDMGFGATKTYDLEVWVPSQNTYREISSCSNMGDFQARRMKARYRMDQKKTELVHTLNGSGLAVGRTLLAVMENYQREDGSIEIPEVLRPYMGGATFID
Atome Classification :
(23 SA)
---------------------------------------------------------------------------------------------.........10----...--.....20.....-.---.--.30.----------.----......------40.....--...50........60.......-----------------------------.70------------------..----......-.80........90........100.......110.......120........130---------------.--------------------.....-----.---140.......150.....-..160.......170.......180.......190.......200.......210.......220..-.----------....230.......240.......250.......260.......270.......280.......290..--.--....300.......310.......320.......330.......340.......350.......360.......370....-------....380.......390.......400.......410.......420...-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------MIMI
D
P
K
L
L
RN----
N
I
E
--
V
V
N
A
A
L
A
KRG
V
Q
-L---
D
--
V
Q
E
W
----------
A
----
S
L
E
T
R
R
------
K
D
L
Q
S
K
T
--
E
K
L
Q
A
ERNA
G
A
K
Q
V
G
Q
I
K
KSGG-----------------------------
D
A
-------------------
S
E
----
I
M
A
R
M
Q
-
A
IG
D
E
I
K
A
A
E
V
A
L
S
E
L
Q
N
E
I
E
Q
K
A
LSIPNLPDESVPAGKDEN-D
N
V
E
I
SKWGTP
R
---------------
Q
--------------------
F
D
F
EI-----K---DHT
D
L
G
E
W
MGGL
E
F
E
T
AT-KLTGS
R
F
S
V
L
K
G
P
L
A
R
L
Q
R
A
L
T
Q
F
M
L
DTHTLKNGYTEA
Y
V
P
Y
L
V
N
A
D
SLRGTGQLP
K
F
E
E
D
L
F
K
LQG-E----------K
E
Y
Y
L
I
PTAEV
P
V
T
N
F
V
R
D
EIIDADRL
P
L
KYAAHTPCFRSEAGSYGR
D
T
R
G
L
I
R
Q
HQFDK
V
E
M
V
Q
I
VKP--
E
--
T
S
M
Q
A
L
E
E
L
T
A
H
A
E
G
I
L
Q
A
LGL
P
Y
R
K
I
L
L
CGGDMGFGA
T
K
T
Y
D
L
E
V
W
VPSQ
N
T
Y
R
E
I
S
S
CSNM
G
D
F
Q
A
R
R
M
K
A
R
YR-M
D
Q
K
-------
K
T
E
L
V
H
TLNGS
G
L
A
V
G
R
T
L
L
A
V
M
E
N
YQREDGSIE
I
P
E
V
L
R
P
YMGGATFID-
48
HHSearch
72.07
38%
-24
- C2 -
-
1SRY
-
SYS_THET2
B:
[1-418]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
--
E
-----------------------------
E
K
-------------------
E
A
----
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
A
--
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
LE
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
--
R
D
P
E
G------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
V
L
E
--
7
PsiBlast_PDB
72.02
38%
-31
- C2 -
-
1SES
1
SYS_THET2
A:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
K
-----------------------------
E
A
-------------------------
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
8
PsiBlast_PDB
71.70
38%
-26
- C2 -
-
1SET
1
SYS_THET2
A:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
K
-----------------------------
E
A
-------------------------
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
44
HHSearch
71.44
55%
55
- C2 -
-
2DQ3
1
SYS_AQUAE
A:
[1-422]
-----------------------------------------------------------------------------------------------
M
I
D
I
N
L
I
R
E
----
K
P
D
--
Y
V
K
E
R
L
A
T
R
D
K
E
L
V
S
--
L
--
V
D
K
V
----------
L
----
E
L
D
K
R
R
------
R
E
I
I
K
R
L
--
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
K
L
K
R
E
G
K
-----------------------------
D
T
-------------------
T
E
----
I
Q
N
R
V
K
-
E
L
K
E
E
I
D
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
K
-
D
N
V
E
V
R
R
W
G
E
P
R
---------------
K
--------------------
F
D
F
E
P
-----
K
---
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
-
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
E
R
------------
D
N
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
K
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
--
K
D
S
K
TG-----
K
N
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
T
D
V
I
---
23
PsiBlast_CBE
71.41
38%
-26
- C2 -
-
1SET
1
SYS_THET2
B:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
K
-----------------------------
E
A
-------------------------
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
24
PsiBlast_CBE
71.32
38%
-28
- C2 -
-
1SES
1
SYS_THET2
B:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
K
-----------------------------
E
A
-------------------------
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
1
PsiBlast_PDB
70.78
54%
58
- C2 -
-
2DQ3
1
SYS_AQUAE
A:
[2-418]
------------------------------------------------------------------------------------------------
I
D
I
N
L
I
R
E
----
K
P
D
--
Y
V
K
E
R
L
A
T
R
D
K
E
-
L
---
V
S
L
V
D
K
V
----------
L
----
E
L
D
K
R
R
------
R
E
I
I
K
R
L
--
E
A
L
R
S
E
R
N
K
L
S
K
E
I
G
K
L
K
R
E
G
K
-----------------------------
D
T
-------------------
T
E
----
I
Q
N
R
V
K
-
E
L
K
E
E
I
D
R
L
E
E
E
L
R
K
V
E
E
E
L
K
N
T
L
L
W
I
P
N
L
P
H
P
S
V
P
V
G
E
D
E
K
-
D
N
V
E
V
R
R
W
G
E
P
R
---------------
K
--------------------
F
D
F
E
P
-----
K
---
P
H
W
E
I
G
E
R
L
G
I
L
D
F
K
R
G
A
-
K
L
S
G
S
R
F
T
V
I
A
G
W
G
A
R
L
E
R
A
L
I
N
F
M
L
D
L
H
T
-
K
K
G
Y
K
E
I
C
P
P
H
L
V
K
P
E
I
L
I
G
T
G
Q
L
P
K
F
E
E
D
L
Y
K
C
E
R
-
D
----------
N
-
L
Y
L
I
P
T
A
E
V
P
L
T
N
L
Y
R
E
E
I
L
K
E
E
N
L
P
I
Y
L
T
A
Y
T
P
C
Y
R
R
E
A
G
A
Y
G
K
D
I
R
G
I
I
R
Q
H
Q
F
D
K
V
E
L
V
K
I
V
H
P
--
D
--
T
S
Y
D
E
L
E
K
L
V
K
D
A
E
E
V
L
Q
L
L
G
L
P
Y
R
V
V
E
L
C
T
G
D
L
G
F
S
A
A
K
T
Y
D
I
E
V
W
F
P
S
Q
N
K
Y
R
E
I
S
S
C
S
N
C
E
D
F
Q
A
R
R
M
N
T
R
F
K
--
D
S
K
TG-----
K
N
R
F
V
H
T
L
N
G
S
G
L
A
V
G
R
T
L
A
A
I
L
E
N
Y
Q
Q
E
D
G
S
V
V
V
P
E
V
L
R
D
Y
V
G
-------
5
PsiBlast_PDB
70.51
38%
-27
- C2 -
-
1SRY
-
SYS_THET2
A:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
E
E
K
-----------------------------
E
A
-------------------------
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
49
HHSearch
70.45
38%
-24
- C2 -
-
1SER
-
B:
[501-918]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
E
L
K
K
R
L
--
Q
E
V
Q
T
E
R
N
Q
V
A
K
R
V
P
K
A
P
P
--
E
-----------------------------
E
K
-------------------
E
A
----
L
I
A
R
G
K
-
A
L
G
E
E
A
K
R
L
E
E
A
L
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
--
A
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
P
-
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
A
--
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
--
S
L
E
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
--
R
D
P
E
G------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
V
L
E
--
50
HHSearch
67.06
40%
18
- C2 -
-
2ZR3
-
SYS_PYRHO
B:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
E
L
-
E
KVK
W
--
V
D
E
I
----------
L
----
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
---------------
V
WKGHLERFLEQSQGKMEYEI
L
E
W
K
P
-----
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
------------
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
--
R
D
R
T
DE-----
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
--
51
HHSearch
67.03
40%
22
- C2 -
-
2DQ0
1
SYS_PYRHO
A:
[1-444]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
E
L
-
E
K
V
K
W
--
V
D
E
I
----------
L
----
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
---------------
V
WKGH
L
E
R
F
L
E
Q
S
QGK
M
E
Y
E
I
L
E
W
K
P
-----
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
R
L
I
-
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
------------
E
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
--
R
D
R
T
D
E
-----
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
F
K
E
I
V
--
3
PsiBlast_PDB
66.62
38%
29
- C2 -
-
2ZR2
1
SYS_PYRHO
A:
[1-439]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
-
E
-
L
---
E
--
K
V
K
W
----------
V
D
E
I
L
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
V
W
KGH
L
E
R
F
L
E
Q
S
QG
K
--------------------
M
E
Y
E
I
L
E
W
K
P
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
-
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
-
E
-----------
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
E
-------
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
-------
2
PsiBlast_PDB
66.58
38%
28
- C2 -
-
2DQ0
1
SYS_PYRHO
A:
[1-439]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
-
E
-
L
---
E
--
K
V
K
W
----------
V
D
E
I
L
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
VWKGH
L
E
R
F
L
E
Q
S
QG
K
--------------------
M
E
Y
E
I
L
E
W
K
P
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
-
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
-
E
-----------
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
E
-------
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
-------
22
PsiBlast_CBE
66.07
38%
29
- C2 -
-
2DQ0
1
SYS_PYRHO
B:
[1-439]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
-
E
-
L
---
E
--
K
V
K
W
----------
V
DEIL
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
VWKGHLERFLEQSQG
K
--------------------
M
E
Y
E
I
LEWKP
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
-
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
-
E
-----------
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
E
-------
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
-------
21
PsiBlast_CBE
66.06
38%
28
- C2 -
-
2ZR2
1
SYS_PYRHO
B:
[1-439]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
-
E
-
L
---
E
--
K
V
K
W
----------
V
DEIL
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
VWKGHLERFLEQSQG
K
--------------------
M
E
Y
E
I
LEWKP
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
-
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
-
E
-----------
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
E
-------
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
-------
4
PsiBlast_PDB
65.84
38%
27
- C2 -
-
2ZR3
-
SYS_PYRHO
A:
[1-439]
-----------------------------------------------------------------------------------------------
M
L
D
I
K
L
I
R
E
----
N
P
E
--
L
V
K
N
D
L
I
K
R
G
-
E
-
L
---
E
--
K
V
K
W
----------
V
D
E
I
L
K
L
D
T
E
W
------
R
T
K
L
K
E
I
--
N
R
L
R
H
E
R
N
K
I
A
V
E
I
G
K
R
R
K
K
G
E
-----------------------------
P
V
-------------------
D
E
----
L
L
A
K
S
R
-
E
I
V
K
R
I
G
E
L
E
N
E
V
E
E
L
K
K
K
I
D
Y
Y
L
W
R
L
P
N
I
T
H
P
S
V
P
V
G
K
D
E
N
-
D
N
V
P
I
R
F
W
G
K
A
R
VWKGH
L
E
R
F
L
E
Q
S
QG
K
--------------------
M
E
Y
E
I
L
E
W
K
P
K
---
L
H
V
D
L
L
E
I
L
G
G
A
D
F
A
R
A
A
-
K
V
S
G
S
R
F
Y
Y
L
L
N
E
I
V
I
L
D
L
A
L
I
R
F
A
L
D
-
R
L
I
E
K
G
F
T
P
V
I
P
P
Y
M
V
R
R
F
V
E
E
G
S
T
S
F
E
D
F
E
D
V
I
Y
K
V
E
D
-
E
-----------
D
L
Y
L
I
P
T
A
E
H
P
L
A
G
M
H
A
N
E
I
L
D
G
K
D
L
P
L
L
Y
V
G
V
S
P
C
F
R
K
E
A
G
T
A
G
K
D
T
K
G
I
F
R
V
H
Q
F
H
K
V
E
Q
F
V
Y
S
R
P
--
E
--
E
S
W
E
W
H
E
K
I
I
R
N
A
E
E
L
F
Q
E
L
E
I
P
Y
R
V
V
N
I
C
T
G
D
L
G
Y
V
A
A
K
K
Y
D
I
E
A
W
M
P
G
Q
G
K
F
R
E
V
V
S
A
S
N
C
T
D
W
Q
A
R
R
L
N
I
R
F
R
D
R
T
D
E
-------
K
P
R
Y
V
H
T
L
N
S
T
A
I
A
T
S
R
A
I
V
A
I
L
E
N
H
Q
E
E
D
G
T
V
R
I
P
K
V
L
W
K
Y
T
G
-------
47
HHSearch
65.14
34%
21
- C2 -
-
3LSS
1
?
B:
[5-468]
---------------------------------------------------------------------------------------------
M
M
V
L
D
I
Q
L
F
R
D
E
T
--
G
A
N
--
I
I
R
E
S
Q
R
R
R
F
A
D
-
P
D
--
I
--
V
D
A
I
----------
I
----
E
A
D
K
K
W
------
R
R
T
Q
F
L
T
--
E
A
S
K
K
L
I
N
I
C
S
K
A
V
G
A
K
K
K
A
K
E
ADGDTSEIP
P
Q
V
K
E
A
Y
E
N
GTLK
G
E
Q
V
E
Q
L
C
V
-------------------
L
Q
----
L
K
Q
L
S
K
-
D
L
S
D
Q
V
A
G
L
A
K
E
A
Q
Q
L
E
E
E
R
D
K
L
M
L
N
V
G
N
I
L
H
E
S
V
P
I
A
Q
D
E
E
T
G
N
T
V
V
R
T
F
G
N
T
T
---------------
K
----------------------
R
A
K
-----
L
---
N
H
V
S
I
M
E
R
L
G
M
M
D
T
S
K
A
V
T
S
M
A
G
G
R
S
Y
V
L
K
G
G
L
V
Q
L
Q
V
A
L
V
S
Y
S
L
D
F
L
V
-
K
R
G
Y
T
P
F
Y
P
P
F
F
L
N
R
D
V
M
G
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
Q
V
S
G
D
G
----------
D
K
K
Y
L
I
A
T
S
E
M
P
I
A
A
Y
H
R
G
R
W
F
T
E
L
K
E
P
L
K
Y
A
G
M
S
T
C
F
R
K
E
A
G
A
H
G
R
D
T
L
G
I
F
R
V
H
Q
F
D
K
I
E
Q
F
V
V
C
S
P
--
R
QE
E
S
W
R
H
L
E
D
M
I
T
T
S
E
E
F
N
K
S
L
G
L
P
Y
R
V
V
N
I
C
S
G
A
L
N
N
A
A
A
K
K
Y
D
L
E
A
W
F
P
A
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
S
Q
S
V
N
C
R
Y
--
G
P
N
L
R
GTAAQN
V
K
E
Y
C
H
M
L
N
G
T
L
C
A
I
T
R
T
M
C
C
I
C
E
N
Y
Q
T
E
E
G
-
V
V
I
P
D
V
L
R
P
Y
M
M
G
I
E
M
I
R
-
6
PsiBlast_PDB
63.58
38%
-24
- C2 -
-
1SER
-
SYS_THET2
A:
[1-413]
-----------------------------------------------------------------------------------------------
M
V
D
L
K
R
L
R
Q
----
E
P
E
--
V
F
H
R
A
I
R
E
K
G
V
A
-
L
---
D
--
L
E
A
L
----------
L
----
A
L
D
R
E
V
------
Q
----------------------------------------------------------------------------------------------------------
R
E
K
E
A
R
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
27
PsiBlast_CBE
62.90
35%
28
- C2 -
-
4RQE
2
SYSC_HUMAN
C:
[15-460]
-------------------------------------------------------------------------------------------------
D
P
A
L
I
R
E
----
T
Q
E
KR
F
K
D
P
G
L
V
D
Q
L
V
K
-
A
---
D
---
S
E
W
----------
R
----
R
C
R
F
R
A
DNLNKL
K
N
L
C
S
K
T
IG
E
K
M
K
-------
E
N
V
L
S
F
D
---
A
-----------------------------
D
A
LANLKV-------------
S
Q
----
I
K
K
V
R
L
-
L
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
V
D
N
K
V
T
S
I
W
G
----------------------------------------
D
C
T
V
-----
R
KKY
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
S
R
-
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
G
-
K
GSEKSDDNSY
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
R
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
R
D
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
DN
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
------MD-----
K
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
--------
52
HHSearch
62.87
35%
20
- C2 -
-
3VBB
-
SYSC_HUMAN
B:
[2-463]
-----------------------------------------------------------------------------------------------
V
L
D
L
D
L
F
R
V
DKGG
D
P
A
--
L
I
R
E
T
Q
E
K
R
F
K
D
-
P
---
G
L
-
V
D
Q
L
----------
V
----
K
A
D
S
E
W
------
R
R
C
R
F
R
A
--
D
N
L
N
K
L
K
N
L
C
S
K
T
I
G
E
K
M
K
K
---------------------------------DESVPENVLSFDDLT
A
D
A
L
A
N
LK
V
S
Q
I
K
K
V
R
L
L
I
D
E
A
I
L
K
C
D
A
E
R
I
K
L
E
A
E
R
F
E
N
L
R
E
I
G
N
L
L
H
P
S
V
P
I
S
N
D
E
D
V
D
N
K
V
E
R
I
W
G
D
C
T
---------------
V
----------------------
R
K
K
-----
Y
---
S
H
V
D
L
V
V
M
V
D
G
F
E
G
E
K
G
A
-
V
V
A
G
S
R
G
Y
F
L
K
G
V
L
V
F
L
E
Q
A
L
I
Q
Y
A
L
R
T
L
G
-
S
R
G
Y
I
P
I
Y
T
P
F
F
M
R
K
E
V
M
Q
E
V
A
Q
L
S
Q
F
D
E
E
L
Y
K
V
I
-------------
D
E
K
Y
L
I
A
T
S
E
Q
P
I
A
A
L
H
R
D
E
W
L
R
P
E
D
L
P
I
K
Y
A
G
L
S
T
C
F
R
Q
E
V
G
S
H
G
--
T
R
G
I
F
R
V
H
Q
F
E
K
I
E
Q
F
V
Y
S
S
P
--
H
DN
K
S
W
E
M
F
E
E
M
I
T
T
A
E
E
F
Y
Q
S
L
G
I
P
Y
H
I
V
N
I
V
S
G
S
L
N
H
A
A
S
K
K
L
D
L
E
A
W
F
P
G
S
G
A
F
R
E
L
V
S
C
S
N
C
T
D
Y
Q
A
R
R
L
R
I
R
Y
--
G
Q
T
K
KMMD---
K
V
E
F
V
H
M
L
N
A
T
M
C
A
T
T
R
T
I
C
A
I
L
E
N
Y
Q
T
E
K
G
-
I
T
V
P
E
K
L
K
E
F
M
P
P
G
-----
26
PsiBlast_CBE
59.15
37%
-18
- C2 -
-
3ERR
1
SYS_THET2
B:
[176-522]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
----
M
L
K
R
V
E
-
P
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
SL
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
11
PsiBlast_PDB
58.59
37%
-13
- C2 -
-
3ERR
1
DYHC1_MOUSE (first)
A:
[176-522]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
----
M
L
K
R
V
E
-
P
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
W
W
E
-
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
-
R
R
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
-
A
-
E
----------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
-------
35
Fugue
57.09
31%
21
- C2 -
-
3ERR
1
DYHC1_MOUSE (first)
A:
[3-529]
D
L
K
R
L
R
Q
E
P
E
V
F
H
R
A
I
R
E
K
GVALD
L
E
A
L
L
A
V
D
E
Q
L
H
K
Q
Q
E
V
I
A
D
K
Q
M
S
V
K
E
D
L
D
K
V
E
P
A
V
I
E
A
Q
N
A
V
K
S
IK
K
Q
H
L
V
E
V
R
S
MANPP
A
A
V
K
L
A
L
E
S
I
A
L
L
L
G
E
S
T
T
----
D
W
K
--
Q
I
R
S
I
I
M
R
E
N
F
I
-
P
---
T
--
I
V
N
F
SAEEIS
D
A
I
R
E
----
K
M
K
K
N
Y
------
M
S
N
P
S
Y
N
--
Y
E
I
V
N
R
A
S
L
A
A
G
P
M
V
K
W
A
I
A
Q
L
-----------------------------
N
Y
-------------------
A
D
----
M
L
K
R
V
E
-
P
L
R
N
E
L
Q
K
L
E
D
D
A
K
D
N
Q
Q
K
L
E
A
L
L
L
Q
V
P
L
P
P
W
P
G
A
P
V
G
G
E
E
A
--
N
R
E
I
K
R
V
G
G
P
P
---------------
E
--------------------
F
S
F
P
P
-----
L
---
D
H
V
A
L
M
E
K
N
G
-
W
W
E
P
R
I
S
-
Q
V
S
G
S
R
S
Y
A
L
K
G
D
L
A
L
Y
E
L
A
L
L
R
F
A
M
D
F
M
A
R
R
-
G
F
L
P
M
T
L
P
S
Y
A
R
E
K
A
F
L
G
T
G
H
F
P
A
Y
R
D
Q
V
W
A
I
A
E
------------
T
D
L
Y
L
T
G
T
A
E
V
V
L
N
A
L
H
S
G
E
I
L
P
Y
E
A
L
P
L
R
Y
A
G
Y
A
P
A
F
R
S
E
A
G
S
F
G
K
D
V
R
G
L
M
R
V
H
Q
F
H
K
V
E
Q
Y
V
L
T
E
A
S
L
E
--
A
S
D
R
A
F
Q
E
L
L
E
N
A
E
E
I
L
R
L
L
E
L
P
Y
R
L
V
E
V
A
T
G
D
M
G
P
G
K
W
R
Q
V
D
I
E
V
Y
L
P
S
E
G
R
Y
R
E
T
H
S
C
S
A
L
L
D
W
Q
A
R
R
A
N
L
R
Y
R
-
D
P
E
G
-------
R
V
R
Y
A
Y
T
L
N
N
T
A
L
A
T
P
R
I
L
A
M
L
L
E
N
H
Q
L
Q
D
G
R
V
R
V
P
Q
A
L
I
P
Y
M
G
K
E
V
L
E
P
G