@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSI0: (2017-12-08 )
MDIFPISLKLQQQRCLIVGGGHIALRKATLLAKAGAIIDVVAPAIEDQLLQLITTTGGVSFIEAFAEKFLSTPYRLVIAATNDAEVNKTVFEQCEARNLLVNSIDDIPHCRFMVPAIIDRSPLIVSVASNGTSPVLSRQIRTQLETSIPHGMGKLAEFSGKWRNQVKEKISNPDERRIFWENLYASPLKEQVFNDNLDVADSMLEQALQEWEAPKGEVYLVGAGPGDPELITLKALRLMQQADVVIYDRLVSAPILELCRRDATKIYVGKERSNHSVPQEGINALLVDYAKKGKRVCRLKGGDPFIFGRGGEEIQELFQAGVPFQIVPGITAASGCSAYAGIPLTHRDYALSVRFLTGHLKEGSPELPWNELVYENQTLVLYMGLVGLERICEQLIAHGQRPDMPVALISKGTTPEQKVVVGSLADIASKVTEHQIHAPTLTIIGEVVRLREQLQWN
Atome Classification :
(20 SA)
.........10........20........30........40........50........60..-.-.....70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.....-..190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360..-.-.....370.......380.......390.......400.......410.......420.......430.......440.......450.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDI
F
P
I
S
L
K
L
QQQ
R
C
L
I
VGG
G
H
I
A
L
R
K
A
T
L
L
AKAG
A
I
I
D
V
V
A
P
A
I
E
D
Q
L
L
Q
L
I
TTTG
G
V
S
F
I
E
-
A
-
F
A
E
K
F
LSTP
Y
R
L
V
I
A
ATNDAE
V
N
K
T
V
F
E
Q
C
E
A
R
N
L
L
V
NSIDDIPHCR
F
M
V
P
A
IIDRS
P
L
I
V
S
VASNGT
S
P
V
L
S
R
Q
I
R
T
Q
L
E
TSIPH
G
M
G
K
L
A
E
F
S
G
K
W
R
N
Q
V
K
E
KISN
P
D
E
R
R
I
F
W
E
N
L
Y
AS
P
-
L
K
E
Q
V
FNDNL
D
V
A
D
S
M
L
E
Q
A
L
Q
E
WEAPKG
E
V
Y
L
V
GAGPGDP
E
L
I
T
L
K
A
L
R
L
M
Q
QA
D
V
V
I
Y
D
R
L
VS
A
P
I
L
E
L
C
RRDA
T
K
I
Y
V
GKERSNHSV
P
Q
E
G
I
N
A
L
L
V
D
Y
A
K
KG
K
R
V
C
RLKGGD
P
F
I
FGR
G
G
E
E
I
Q
E
L
F
QAGV
P
F
Q
IVPGITAASGCSAYAGIPLTHR
D
Y
A
L
S
V
R
F
LTGHLK-EG-S-PELP
W
N
E
LVYEN
Q
T
L
V
L
Y
M
G
L
V
G
L
E
R
I
C
E
Q
L
I
AHGQRPDM
P
V
A
L
ISKGTTPE
Q
K
V
V
V
G
S
L
A
D
I
A
S
K
V
T
EHQIHA
P
T
L
T
I
I
G
E
V
V
R
L
R
E
Q
LQWN
2
HHSearch
79.85
50%
-21
- C1 -
-
1PJT
1
CYSG_SALTY
B:
[1-454]
M
D
H
L
P
I
F
C
Q
L
R
D
R
D
C
L
I
V
G
G
G
D
V
A
E
R
K
A
R
L
L
L
E
A
G
A
R
L
T
V
N
A
L
T
F
I
P
Q
F
T
V
-
W
A
N
E
G
M
L
T
L
V
E
G
P
-
F
D
E
T
L
L
D
-
S
C
W
L
A
I
A
A
T
D
D
D
T
V
N
Q
R
V
S
D
A
A
E
S
R
R
I
F
C
N
V
V
D
A
P
K
A
A
S
F
I
M
P
S
I
I
D
R
S
P
L
M
V
A
V
S
A
G
G
T
S
P
V
L
A
R
L
L
R
E
K
L
E
S
L
L
P
Q
H
L
G
Q
V
A
R
Y
A
G
Q
L
R
A
R
V
K
K
Q
F
A
T
M
G
E
R
R
R
F
W
E
K
F
F
V
N
D
R
L
A
Q
S
L
A
N
A
D
E
K
A
V
N
A
T
T
E
R
L
F
S
E
P
L
D
H
R
G
E
V
V
L
V
G
A
G
P
G
D
A
G
L
L
T
L
K
G
L
Q
Q
I
Q
Q
A
D
I
V
V
Y
D
R
L
V
S
D
D
I
M
N
L
V
R
R
D
A
D
R
V
F
V
G
K
R
A
--
H
C
V
P
Q
E
E
I
N
Q
I
L
L
R
E
A
Q
K
G
K
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
G
E
E
L
E
T
L
C
H
A
G
I
P
F
S
V
V
P
G
I
T
A
A
S
G
C
S
A
Y
S
G
I
P
L
T
H
R
D
Y
A
Q
S
V
R
L
V
T
G
H
L
K
-
T
G
-
G
--
E
L
D
W
E
N
L
A
A
E
K
Q
T
L
V
F
Y
M
G
L
N
Q
A
A
T
I
Q
E
K
L
I
A
F
G
M
Q
A
D
M
P
V
A
L
V
E
N
G
T
S
V
K
Q
R
V
V
H
G
V
L
T
Q
L
G
E
L
A
--
Q
Q
V
E
S
P
A
L
I
I
V
G
R
V
V
A
L
R
D
K
L
N
W
F
1
HHSearch
79.72
50%
-18
- C1 -
-
1PJQ
1
CYSG_SALTY
A:
[1-454]
M
D
H
L
P
I
F
C
Q
L
R
D
R
D
C
L
I
V
G
G
G
D
V
A
E
R
K
A
R
L
L
L
E
A
G
A
R
L
T
V
N
A
L
T
F
I
P
Q
F
T
V
-
W
A
N
E
G
M
L
T
L
V
E
G
P
-
F
D
E
T
L
L
D
-
S
C
W
L
A
I
A
A
T
D
D
D
T
V
N
Q
R
V
S
D
A
A
E
S
R
R
I
F
C
N
V
V
D
A
P
K
A
A
S
F
I
M
P
S
I
I
D
R
S
P
L
M
V
A
V
S
S
G
G
T
S
P
V
L
A
R
L
L
R
E
K
L
E
S
L
L
P
Q
H
L
G
Q
V
A
R
Y
A
G
Q
L
R
A
R
V
K
K
Q
F
A
T
M
G
E
R
R
R
F
W
E
K
F
F
V
N
D
R
L
A
Q
S
L
A
N
A
D
E
K
A
V
N
A
T
T
E
R
L
F
S
E
P
L
D
H
R
G
E
V
V
L
V
G
A
G
P
G
D
A
G
L
L
T
L
K
G
L
Q
Q
I
Q
Q
A
D
I
V
V
Y
D
R
L
V
S
D
D
I
M
N
L
V
R
R
D
A
D
R
V
F
V
G
K
R
---
H
C
V
P
Q
E
E
I
N
Q
I
L
L
R
E
A
Q
K
G
K
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
G
E
E
L
E
T
L
C
H
A
G
I
P
F
S
V
V
P
G
I
T
A
A
S
G
C
S
A
Y
S
G
I
P
L
T
H
R
D
Y
A
Q
S
V
R
L
V
T
--------
G
--
E
L
D
W
E
N
L
A
A
E
K
Q
T
L
V
F
Y
M
G
L
N
Q
A
A
T
I
Q
E
K
L
I
A
F
G
M
Q
A
D
M
P
V
A
L
V
E
N
G
T
S
V
K
Q
R
V
V
H
G
V
L
T
Q
L
G
E
L
A
--
Q
Q
V
E
S
P
A
L
I
I
V
G
R
V
V
A
L
R
D
K
L
N
W
F
53
PsiBlast_CBE
79.66
49%
-21
* C1 *
-
1PJT
1
CYSG_SALTY
B:
[1-453]
M
D
H
L
P
I
F
C
Q
L
R
D
R
D
C
L
I
V
G
G
G
D
V
A
E
R
K
A
R
L
L
L
E
A
G
A
R
L
T
V
N
A
L
T
F
I
P
Q
F
-
T
V
W
A
N
E
G
M
L
T
L
V
E
-
G
P
F
D
E
T
L
L
D
S
C
W
-
L
A
I
A
A
T
D
D
D
T
V
N
Q
R
V
S
D
A
A
E
S
R
R
I
F
C
N
V
V
D
A
P
K
A
A
S
F
I
M
P
S
I
I
D
R
S
P
L
M
V
A
V
S
A
G
G
T
S
P
V
L
A
R
L
L
R
E
K
L
E
S
L
L
P
Q
H
L
G
Q
V
A
R
Y
A
G
Q
L
R
A
R
V
K
K
Q
F
A
T
M
G
E
R
R
R
F
W
E
K
F
F
V
N
D
R
L
A
Q
S
L
A
N
A
D
E
K
A
V
N
A
T
T
E
R
L
F
S
E
P
L
D
H
R
G
E
V
V
L
V
G
A
G
P
G
D
A
G
L
L
T
L
K
G
L
Q
Q
I
Q
Q
A
D
I
V
V
Y
D
R
L
V
S
D
D
I
M
N
L
V
R
R
D
A
D
R
V
F
V
G
K
R
A
--
H
C
V
P
Q
E
E
I
N
Q
I
L
L
R
E
A
Q
K
G
K
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
G
E
E
L
E
T
L
C
H
A
G
I
P
F
S
V
V
P
G
I
T
A
A
S
G
C
S
A
Y
S
G
I
P
L
T
H
R
D
Y
A
Q
S
V
R
L
V
T
G
H
L
K
-
T
G
-
G
--
E
L
D
W
E
N
L
A
A
E
K
Q
T
L
V
F
Y
M
G
L
N
Q
A
A
T
I
Q
E
K
L
I
A
F
G
M
Q
A
D
M
P
V
A
L
V
E
N
G
T
S
V
K
Q
R
V
V
H
G
V
L
T
Q
L
G
E
--
L
A
Q
Q
V
E
S
P
A
L
I
I
V
G
R
V
V
A
L
R
D
K
L
N
W
-
34
PsiBlast_PDB
79.48
49%
-18
- C1 -
-
1PJQ
1
CYSG_SALTY
A:
[1-453]
M
D
H
L
P
I
F
C
Q
L
R
D
R
D
C
L
I
V
G
G
G
D
V
A
E
R
K
A
R
L
L
L
E
A
G
A
R
L
T
V
N
A
L
T
F
I
P
Q
F
-
T
V
W
A
N
E
G
M
L
T
L
V
E
-
G
P
F
D
E
T
L
L
D
S
C
W
-
L
A
I
A
A
T
D
D
D
T
V
N
Q
R
V
S
D
A
A
E
S
R
R
I
F
C
N
V
V
D
A
P
K
A
A
S
F
I
M
P
S
I
I
D
R
S
P
L
M
V
A
V
S
S
G
G
T
S
P
V
L
A
R
L
L
R
E
K
L
E
S
L
L
P
Q
H
L
G
Q
V
A
R
Y
A
G
Q
L
R
A
R
V
K
K
Q
F
A
T
M
G
E
R
R
R
F
W
E
K
F
F
V
N
D
R
L
A
Q
S
L
A
N
A
D
E
K
A
V
N
A
T
T
E
R
L
F
S
E
P
L
D
H
R
G
E
V
V
L
V
G
A
G
P
G
D
A
G
L
L
T
L
K
G
L
Q
Q
I
Q
Q
A
D
I
V
V
Y
D
R
L
V
S
D
D
I
M
N
L
V
R
R
D
A
D
R
V
F
V
G
K
R
---
H
C
V
P
Q
E
E
I
N
Q
I
L
L
R
E
A
Q
K
G
K
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
G
E
E
L
E
T
L
C
H
A
G
I
P
F
S
V
V
P
G
I
T
A
A
S
G
C
S
A
Y
S
G
I
P
L
T
H
R
D
Y
A
Q
S
V
R
L
V
T
--------
G
--
E
L
D
W
E
N
L
A
A
E
K
Q
T
L
V
F
Y
M
G
L
N
Q
A
A
T
I
Q
E
K
L
I
A
F
G
M
Q
A
D
M
P
V
A
L
V
E
N
G
T
S
V
K
Q
R
V
V
H
G
V
L
T
Q
L
G
E
--
L
A
Q
Q
V
E
S
P
A
L
I
I
V
G
R
V
V
A
L
R
D
K
L
N
W
-
33
PsiBlast_PDB
78.58
49%
-17
- C1 -
-
1PJT
1
CYSG_SALTY
A:
[1-453]
M
D
H
L
P
I
F
C
Q
L
R
D
R
D
C
L
I
V
G
G
G
D
V
A
E
R
K
A
R
L
L
L
E
A
G
A
R
L
T
V
N
A
L
T
F
I
P
Q
F
-
T
V
W
A
N
E
G
M
L
T
L
V
E
-
G
P
F
D
E
T
L
L
D
S
C
W
-
L
A
I
A
A
T
D
D
D
T
V
N
Q
R
V
S
D
A
A
E
S
R
R
I
F
C
N
V
V
D
A
P
K
A
A
S
F
I
M
P
S
I
I
D
R
S
P
L
M
V
A
V
S
A
G
G
T
S
P
V
L
A
R
L
L
R
E
K
L
E
S
L
L
P
Q
H
L
G
Q
V
A
R
Y
A
G
Q
L
R
A
R
V
K
K
Q
F
A
T
M
G
E
R
R
R
F
W
E
K
F
F
V
N
D
R
L
A
Q
S
L
A
N
A
D
E
K
A
V
N
A
T
T
E
R
L
F
S
E
P
L
D
H
R
G
E
V
V
L
V
G
A
G
P
G
D
A
G
L
L
T
L
K
G
L
Q
Q
I
Q
Q
A
D
I
V
V
Y
D
R
L
V
S
D
D
I
M
N
L
V
R
R
D
A
D
R
V
F
V
G
K
R
---
H
C
V
P
Q
E
E
I
N
Q
I
L
L
R
E
A
Q
K
G
K
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
G
E
E
L
E
T
L
C
H
A
G
I
P
F
S
V
V
P
G
I
T
A
A
S
G
C
S
A
Y
S
G
I
P
L
T
H
R
D
Y
A
Q
S
V
R
L
V
T
--------
G
--
E
L
D
W
E
N
L
A
A
E
K
Q
T
L
V
F
Y
M
G
L
N
Q
A
A
T
I
Q
E
K
L
I
A
F
G
M
Q
A
D
M
P
V
A
L
V
E
N
G
T
S
V
K
Q
R
V
V
H
G
V
L
T
Q
L
G
E
--
L
A
Q
Q
V
E
S
P
A
L
I
I
V
G
R
V
V
A
L
R
D
K
L
N
W
-
35
PsiBlast_PDB
77.66
49%
-17
- C1 -
-
1PJS
5
CYSG_SALTY
A:
[1-453]
M
D
H
L
P
I
F
C
Q
L
R
D
R
D
C
L
I
V
G
G
G
D
V
A
E
R
K
A
R
L
L
L
E
A
G
A
R
L
T
V
N
A
L
T
F
I
P
Q
F
-
T
V
W
A
N
E
G
M
L
T
L
V
E
-
G
P
F
D
E
T
L
L
D
S
C
W
-
L
A
I
A
A
T
D
D
D
T
V
N
Q
R
V
S
D
A
A
E
S
R
R
I
F
C
N
V
V
D
A
P
K
A
A
S
F
I
M
P
S
I
I
D
R
S
P
L
M
V
A
V
S
S
G
G
T
S
P
V
L
A
R
L
L
R
E
K
L
E
S
L
L
P
Q
H
L
G
Q
V
A
R
Y
A
G
Q
L
R
A
R
V
K
K
Q
F
A
T
M
G
E
R
R
R
F
W
E
K
F
F
V
N
D
R
L
A
Q
S
L
A
N
A
D
E
K
A
V
N
A
T
T
E
R
L
F
S
E
P
L
D
H
R
G
E
V
V
L
V
G
A
G
P
G
D
A
G
L
L
T
L
K
G
L
Q
Q
I
Q
Q
A
D
I
V
V
Y
D
R
L
V
S
D
D
I
M
N
L
V
R
R
D
A
D
R
V
F
V
--------
V
P
Q
E
E
I
N
Q
I
L
L
R
E
A
Q
K
G
K
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
G
E
E
L
E
T
L
C
H
A
G
I
P
F
S
V
V
P
G
I
T
A
A
S
G
C
S
A
Y
S
G
I
P
L
T
H
R
D
Y
A
Q
S
V
R
L
V
T
--------
G
--
E
L
D
W
E
N
L
A
A
E
K
Q
T
L
V
F
Y
M
G
L
N
Q
A
A
T
I
Q
E
K
L
I
A
F
G
M
Q
A
D
M
P
V
A
L
V
E
N
G
T
S
V
K
Q
R
V
V
H
G
V
L
T
Q
L
G
E
--
L
A
Q
Q
V
E
S
P
A
L
I
I
V
G
R
V
V
A
L
R
D
K
L
N
W
-
37
PsiBlast_PDB
71.60
52%
-153
- C1 -
-
2YBQ
2
?
A:
[18-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
A
G
S
V
A
L
V
G
A
G
P
G
D
P
G
L
L
T
L
R
A
W
A
L
L
Q
Q
A
E
V
V
V
Y
D
R
L
V
A
R
E
L
I
A
L
L
P
E
S
C
Q
R
I
Y
V
G
--------
P
Q
E
E
I
N
E
L
L
V
R
L
A
R
Q
Q
R
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
A
E
E
L
E
R
L
L
E
A
G
V
D
C
Q
V
V
P
G
V
T
A
A
S
G
C
S
T
Y
A
G
I
P
L
T
H
R
D
L
A
Q
S
C
T
F
V
T
G
H
L
Q
------
L
D
L
D
W
A
G
L
A
R
G
K
Q
T
L
V
F
Y
M
G
L
G
N
L
A
E
I
A
A
R
L
V
E
H
G
L
A
S
D
T
P
A
A
L
V
S
Q
G
T
Q
A
G
Q
Q
V
T
R
G
A
L
A
E
L
P
A
L
A
R
R
Y
Q
L
K
P
P
T
L
I
V
V
G
Q
V
V
A
L
-------
10
HHSearch
71.05
54%
-152
- C1 -
-
2YBQ
2
?
A:
[18-257]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
A
G
S
V
A
L
V
G
A
G
P
G
D
P
G
L
L
T
L
R
A
W
A
L
L
Q
Q
A
E
V
V
V
Y
D
R
L
V
A
R
E
L
I
A
L
L
P
E
S
C
Q
R
I
Y
V
G
--------
P
Q
E
E
I
N
E
L
L
V
R
L
A
R
Q
Q
R
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
A
E
E
L
E
R
L
L
E
A
G
V
D
C
Q
V
V
P
G
V
T
A
A
S
G
C
S
T
Y
A
G
I
P
L
T
H
R
D
L
A
Q
S
C
T
F
V
T
G
H
L
Q
------
L
D
L
D
W
A
G
L
A
R
G
K
Q
T
L
V
F
Y
M
G
L
G
N
L
A
E
I
A
A
R
L
V
E
H
G
L
A
S
D
T
P
A
A
L
V
S
Q
G
T
Q
A
G
Q
Q
V
T
R
G
A
L
A
E
L
P
A
L
A
R
R
Y
Q
L
K
P
P
T
L
I
V
V
G
Q
V
V
A
--------
60
PsiBlast_CBE
68.13
45%
-135
- C1 -
-
1S4D
1
SUMT_PSEDE
G:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
K
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
S
-
S
G
-
P
-
D
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
62
PsiBlast_CBE
68.09
45%
-137
- C1 -
-
1S4D
1
SUMT_PSEDE
E:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
K
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
S
-
S
G
-
P
-
D
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
59
PsiBlast_CBE
67.83
45%
-147
- C1 -
-
1S4D
1
SUMT_PSEDE
H:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
K
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
--------
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
38
PsiBlast_PDB
67.64
45%
-142
- C1 -
-
1S4D
3
SUMT_PSEDE
A:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
--
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
--------
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
57
PsiBlast_CBE
67.48
45%
-148
- C1 -
-
1S4D
1
SUMT_PSEDE
J:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
----
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
--------
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
54
PsiBlast_CBE
67.17
45%
-145
- C1 -
-
1S4D
13
SUMT_PSEDE
M:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
-
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
--------
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
6
HHSearch
67.06
45%
-133
- C1 -
-
1S4D
1
SUMT_PSEDE
E:
[10-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
L
E
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
K
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
S
-
S
G
-
P
-
D
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
I
63
PsiBlast_CBE
66.04
45%
-141
- C1 -
-
1S4D
1
SUMT_PSEDE
D:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
-----
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
S
-
S
G
----
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
36
PsiBlast_PDB
65.75
52%
-104
- C1 -
-
2YBO
1
?
A:
[18-260]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
V
D
F
P
A
G
S
V
A
L
V
G
A
G
P
G
D
P
G
L
L
T
L
R
A
W
A
L
L
Q
Q
A
E
V
V
V
Y
D
R
L
V
A
R
E
L
I
A
L
L
P
E
S
C
Q
R
I
Y
V
G
--------
P
Q
E
E
I
N
E
L
L
V
R
L
A
R
Q
Q
R
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
A
E
E
L
E
R
L
L
E
A
G
V
D
C
Q
V
V
P
G
V
T
A
A
S
G
C
S
T
Y
A
G
I
P
L
T
H
R
D
L
A
Q
S
C
T
F
V
T
G
H
L
Q
N
D
G
-
R
-
L
D
L
D
W
A
G
L
A
R
G
K
Q
T
L
V
F
Y
M
G
L
G
N
L
A
E
I
A
A
R
L
V
E
H
G
L
A
S
D
T
P
A
A
L
V
S
Q
G
T
Q
A
G
Q
Q
V
T
R
G
A
L
A
E
L
P
A
L
A
R
R
Y
Q
L
K
P
P
T
L
I
V
V
G
Q
V
V
A
L
-------
8
HHSearch
65.59
54%
-104
- C1 -
-
2YBO
1
?
A:
[20-259]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
A
G
S
V
A
L
V
G
A
G
P
G
D
P
G
L
L
T
L
R
A
W
A
L
L
Q
Q
A
E
V
V
V
Y
D
R
L
V
A
R
E
L
I
A
L
L
P
E
S
C
Q
R
I
Y
V
G
--------
P
Q
E
E
I
N
E
L
L
V
R
L
A
R
Q
Q
R
R
V
V
R
L
K
G
G
D
P
F
I
F
G
R
G
A
E
E
L
E
R
L
L
E
A
G
V
D
C
Q
V
V
P
G
V
T
A
A
S
G
C
S
T
Y
A
G
I
P
L
T
H
R
D
L
A
Q
S
C
T
F
V
T
G
H
L
Q
-
N
D
-
G
R
L
D
L
D
W
A
G
L
A
R
G
K
Q
T
L
V
F
Y
M
G
L
G
N
L
A
E
I
A
A
R
L
V
E
H
G
L
A
S
D
T
P
A
A
L
V
S
Q
G
T
Q
A
G
Q
Q
V
T
R
G
A
L
A
E
L
P
A
L
A
R
R
Y
Q
L
K
P
P
T
L
I
V
V
G
Q
V
V
A
--------
64
PsiBlast_CBE
65.36
45%
-106
- C1 -
-
1S4D
2
SUMT_PSEDE
B:
[14-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
K
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
S
-
S
G
V
P
-
D
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
-
7
HHSearch
64.77
45%
-103
- C1 -
-
1S4D
2
SUMT_PSEDE
B:
[10-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
L
E
K
G
S
V
W
L
V
G
A
G
P
G
D
P
G
L
L
T
L
H
A
A
N
A
L
R
Q
A
D
V
I
V
H
D
A
L
V
N
E
D
C
L
K
L
A
R
P
G
A
V
L
E
F
A
G
K
R
G
G
K
P
S
P
K
Q
R
D
I
S
L
R
L
V
E
L
A
R
A
G
N
R
V
L
R
L
K
G
G
D
P
F
V
F
G
R
G
G
E
E
A
L
T
L
V
E
H
Q
V
P
F
R
I
V
P
G
I
T
A
G
I
G
G
L
A
Y
A
G
I
P
V
T
H
R
E
V
N
H
A
V
T
F
L
T
G
H
D
S
-
S
G
V
P
-
D
R
I
N
W
Q
G
I
A
S
G
S
P
V
I
V
M
Y
M
A
M
K
H
I
G
A
I
T
A
N
L
I
A
G
G
R
S
P
D
E
P
V
A
F
V
C
N
A
A
T
P
Q
Q
A
V
L
E
T
T
L
A
R
A
E
A
D
V
A
A
A
G
L
E
P
P
A
I
V
V
V
G
E
V
V
R
L
R
A
A
L
D
W
I