@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSI8: (2017-12-08 )
MAKPYYEFFCPVKVIAGNAALEHIPFELATLGAKRPLIITDKGVRANGLLNPIEAAFSTTDAVIGHVFDDVPPDSSLEVVRLAAEAYRTNKCDAIIAVGGGSVIDTSKATNILVSEGGDDLLQYSGAHNLPKPLKPFFVIPTTSGTGSEVTMVAVVSDTQKNVKLAFASYYLMPHAAILDPRMTLTLPPHLTAMTGMDALTHCVEAYTCMAANPLSDAYASAGIKKISENLFNVLENPNDSQGRLELAQASTMAGIAFSNSMVGLVHSLGHALGAVAHLPHGLCMNLFLPYVLEYNKQINGQKIGELLLPLAGADIYAQTPATQRADRAIATILAMRDRLFSLTKLPRTLRETGKVTEAQLDEVAEKALNDGSIIYNPKEASLKDLREILQKAW
Atome Classification :
(20 SA)
.........10........20........30........40..-..--.-...50......--..60........70........80........90........100.......110......-.120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320......--.330....-...340.......350.......360.......370.......380.......390..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAK
P
Y
Y
E
F
FC
P
V
K
V
I
AGN
A
A
L
EHI
P
F
E
L
A
TLGAKR
P
L
I
I
TDKG-VR--A-NGLL
N
P
I
E
A
A
F--S
T
T
D
A
V
I
G
H
V
FDDVPPDS
S
L
E
V
V
R
L
A
A
E
A
YRTNKC
D
A
I
I
A
VGGG
S
V
I
DTSKA
T
N
I
L
V
SEGG-D
D
L
L
QYSGAHNLPKPLK
P
F
F
V
I
PTTSGTGS
E
V
T
M
V
A
V
VSDTQK
N
V
K
L
A
F
A
S
Y
YLMP
H
A
AILDP
R
M
T
L
TLPP
H
L
T
A
M
T
G
M
D
A
L
T
H
C
V
E
A
Y
T
CMAANP
L
S
D
A
Y
A
S
A
G
I
K
K
I
S
E
N
L
F
N
V
LENPNDSQG
R
L
E
L
AQAS
T
M
A
G
I
AFS
N
S
M
V
G
L
V
H
S
L
G
H
A
L
G
A
V
A
HLP
H
G
L
C
M
N
L
F
L
P
Y
V
L
E
Y
NKQIN
G
Q
K
I
G
E
L
L
LPLAGA
D
I
Y
AQTPA
T
Q
R
A
D
R
--
A
I
A
T
I
L
A
M
-
R
D
R
L
F
S
L
T
K
L
P
R
T
L
R
ETGK
V
T
E
A
Q
L
D
E
V
A
E
K
ALNDG
S
I
I
YNPKEA
S
L
K
D
L
R
E
I
L
Q
KAW
61
HHSearch
93.85
35%
-102
- C5 -
-
3BFJ
-
DHAT_KLEPN
J:
[4-387]
---
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
K
G
-
L
R
--
K
-
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
-
G
I
E
V
A
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
--
G
D
L
Y
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
-
I
A
E
L
M
G
E
N
I
T
G
-
L
S
T
L
D
A
A
E
K
--
A
I
A
A
I
T
R
L
-
S
M
---
D
I
G
-
I
P
Q
H
L
R
D
L
G
V
-
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
60
HHSearch
90.17
31%
-99
- C5 -
-
3OX4
1
ADH2_ZYMMO
B:
[2-383]
---
A
S
S
T
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
-
M
N
--
K
-
S
G
V
V
K
Q
V
A
D
L
L
--
K
A
Q
-
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
--
G
E
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
-
V
G
V
A
M
G
L
D
I
A
N
-
L
G
D
K
E
G
A
E
A
--
T
I
Q
A
V
R
D
L
-
A
A
---
S
I
G
-
I
P
A
N
L
T
E
L
G
A
-
K
K
E
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
4
PsiBlast_PDB
86.55
32%
-73
- C5 -
-
3OX4
1
ADH2_ZYMMO
A:
[6-383]
-------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
-
M
N
--
K
-
S
G
V
V
K
Q
V
-
A
D
L
--
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
-
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
-
G
L
D
I
------
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
-
R
D
L
A
A
S
I
-
G
I
P
A
N
L
T
E
L
G
A
K
K
E
-
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
41
PsiBlast_CBE
86.43
32%
-71
- C5 -
-
3OX4
1
ADH2_ZYMMO
C:
[6-383]
-------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
-
M
N
--
K
-
S
G
V
V
K
Q
V
-
A
D
L
--
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
-
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
-
G
L
D
I
------
A
N
L
G
D
K
EG
A
E
A
T
I
Q
A
V
-
R
D
L
A
A
S
I
-
G
I
P
A
N
L
T
E
L
G
A
K
K
E
-
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
3
PsiBlast_PDB
85.98
32%
-74
- C5 -
-
3OWO
-
ADH2_ZYMMO
A:
[6-383]
-------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
-
M
N
--
K
-
S
G
V
V
K
Q
V
-
A
D
L
--
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
-
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
-
G
L
D
I
------
A
N
L
G
D
K
E
G
A
E
A
T
I
Q
A
V
-
R
D
L
A
A
S
I
-
G
I
P
A
N
L
T
E
L
G
A
K
K
E
-
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
40
PsiBlast_CBE
85.35
32%
-71
- C5 -
-
3OX4
1
ADH2_ZYMMO
D:
[6-383]
-------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
-
M
N
--
K
-
S
G
V
V
K
Q
V
-
A
D
L
--
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
-
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
-
G
L
D
I
------
A
N
L
G
D
K
EG
A
E
A
T
I
Q
A
V
-
R
D
L
A
A
S
I
-
G
I
P
A
N
L
T
E
L
G
A
K
K
E
-
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
42
PsiBlast_CBE
85.26
32%
-72
- C5 -
-
3OX4
1
ADH2_ZYMMO
B:
[6-383]
-------
F
Y
I
P
F
V
N
E
M
G
E
G
S
L
E
K
A
I
K
D
L
N
G
S
G
F
K
N
A
L
I
V
S
D
A
F
-
M
N
--
K
-
S
G
V
V
K
Q
V
-
A
D
L
--
L
K
A
Q
G
I
N
S
A
V
Y
D
G
V
M
P
N
P
T
V
T
A
V
L
E
G
L
K
I
L
K
D
N
N
S
D
F
V
I
S
L
G
G
G
S
P
H
D
C
A
K
A
I
A
L
V
A
T
N
G
G
-
E
-
V
K
D
Y
E
G
I
D
K
S
K
K
P
A
L
P
L
M
S
I
N
T
T
A
G
T
A
S
E
M
T
R
F
C
I
I
T
D
E
V
R
H
V
K
M
A
I
V
D
R
H
V
T
P
M
V
S
V
N
D
P
L
L
M
V
G
M
P
K
G
L
T
A
A
T
G
M
D
A
L
T
H
A
F
E
A
Y
S
S
T
A
A
T
P
I
T
D
A
C
A
L
K
A
A
S
M
I
A
K
N
L
K
T
A
C
D
N
G
K
D
M
P
A
R
E
A
M
A
Y
A
Q
F
L
A
G
M
A
F
N
N
A
S
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Y
Y
N
L
P
H
G
V
C
N
A
V
L
L
P
H
V
L
A
Y
N
A
S
V
V
A
G
R
L
K
D
V
G
V
A
M
-
G
L
D
I
------
A
N
L
G
D
K
EG
A
E
A
T
I
Q
A
V
-
R
D
L
A
A
S
I
-
G
I
P
A
N
L
T
E
L
G
A
K
K
E
-
D
V
P
L
L
A
D
H
A
L
K
D
A
C
A
L
T
N
P
R
Q
G
D
Q
K
E
V
E
E
L
F
L
S
A
F
1
PsiBlast_PDB
84.44
34%
-35
- C5 -
-
3BFJ
-
DHAT_KLEPN
A:
[4-387]
---
R
M
F
D
Y
L
V
P
N
V
N
F
F
G
P
N
A
I
S
V
V
G
E
R
C
Q
L
L
G
G
K
K
A
L
L
V
T
D
K
G
-
L
R
---K
D
G
A
V
D
K
T
L
H
Y
L
--
R
E
A
G
I
E
V
A
-
I
F
D
G
V
E
P
N
P
K
D
T
N
V
R
D
G
L
A
V
F
R
R
E
Q
C
D
I
I
V
T
V
G
G
G
S
P
H
D
C
G
K
G
I
G
I
A
A
T
H
E
G
-
D
-
L
Y
Q
Y
A
G
I
E
T
L
T
N
P
L
P
P
I
V
A
V
N
T
T
A
G
T
A
S
E
V
T
R
H
C
V
L
T
N
T
E
T
K
V
K
F
V
I
V
S
W
R
N
L
P
S
V
S
I
N
D
P
L
L
M
I
G
K
P
A
A
L
T
A
A
T
G
M
D
A
L
T
H
A
V
E
A
Y
I
S
K
D
A
N
P
V
T
D
A
A
A
M
Q
A
I
R
L
I
A
R
N
L
R
Q
A
V
A
L
G
S
N
L
Q
A
R
E
Y
M
A
Y
A
S
L
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
L
Y
D
M
P
H
G
V
A
N
A
V
L
L
P
H
V
A
R
Y
N
L
I
A
N
P
E
K
F
A
D
-
I
A
E
L
M
G
E
N
I
T
G
L
S
-
T
L
D
A
A
E
K
--
A
I
A
A
I
-----
T
R
L
S
M
D
I
G
I
P
Q
H
L
R
D
L
G
-
V
K
E
T
D
F
P
Y
M
A
E
M
A
L
K
D
G
N
A
F
S
N
P
R
K
G
N
E
Q
E
I
A
A
I
F
R
Q
A
F
16
PsiBlast_PDB
79.34
25%
-113
- C5 -
-
3HL0
2
?
A:
[4-347]
--
Q
P
F
V
Y
M
A
A
P
A
R
I
V
F
S
A
G
S
S
A
D
V
A
E
E
I
R
R
L
G
L
S
R
A
L
V
L
S
T
P
Q
-
Q
K
--
G
-
D
A
-----
E
A
L
A
--
S
R
L
G
R
L
A
A
G
V
F
S
E
A
A
M
H
T
P
V
E
V
T
K
T
A
V
E
A
Y
R
A
A
G
A
D
C
V
V
S
L
G
G
G
S
T
T
G
L
G
K
A
I
A
L
R
T
------
D
A
A
Q
--------------
I
V
I
P
T
T
Y
-
A
G
S
E
V
T
--
P
I
L
G
Q
T
E
N
G
V
K
T
T
M
R
G
P
E
I
L
P
E
V
V
I
Y
D
A
E
L
T
L
G
L
P
V
A
I
S
M
T
S
G
L
N
A
M
A
H
A
A
E
A
L
Y
A
R
D
R
N
P
I
A
S
M
M
A
V
E
G
L
R
A
M
I
E
A
L
P
V
V
R
Q
A
P
H
D
I
G
A
R
E
T
A
L
Y
G
A
W
L
C
G
T
V
L
G
A
V
G
M
S
L
H
H
K
L
C
H
T
L
G
G
S
L
D
L
P
H
A
E
T
H
A
V
L
L
P
H
T
I
A
Y
V
E
----
E
A
A
P
N
L
L
A
P
L
----------
A
A
L
V
G
G
R
--
A
G
A
G
L
F
D
F
-
A
A
R
L
G
A
----
P
S
S
L
A
A
L
G
-
V
G
A
D
D
L
D
P
M
A
E
--
L
A
T
A
N
P
Y
W
C
P
R
P
I
E
K
T
A
I
R
D
L
L
Q
R
A
F
62
HHSearch
78.70
30%
-51
- C5 -
-
1RRM
2
FUCO_ECOLI
A:
[2-383]
---
M
A
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
-
I
A
R
V
M
G
V
K
V
E
G
-
M
S
L
E
E
A
R
N
A
--
A
V
E
A
V
F
A
L
-
N
R
---
D
V
G
-
I
P
P
H
L
R
D
V
G
V
-
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
63
HHSearch
78.41
30%
-53
- C5 -
-
5BR4
3
FUCO_ECOLI
B:
[2-383]
---
M
A
N
R
M
I
L
N
E
T
A
W
F
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
--
D
K
D
A
G
E
E
M
A
L
G
Q
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
-
I
A
R
V
M
G
V
K
V
E
G
-
M
S
L
E
E
A
R
N
A
--
A
V
E
A
V
F
A
L
-
N
R
---
D
V
G
-
I
P
P
H
L
R
D
V
G
V
-
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
2
PsiBlast_PDB
77.86
32%
-19
- C5 -
-
4FR2
-
?
A:
[16-398]
----
A
Y
D
F
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
M
K
K
P
V
I
V
T
D
K
F
-
L
E
N
L
K
-
N
G
A
V
A
Q
T
L
A
S
L
K
K
S
G
V
D
Y
V
---
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
G
--
D
D
I
T
K
L
A
G
I
E
T
L
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
A
V
A
N
G
H
N
L
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
L
A
R
I
M
G
-----
E
N
T
D
G
L
S
T
R
D
A
--
A
E
L
S
I
K
A
M
-
K
-
Q
L
S
E
D
V
G
I
P
H
S
I
K
D
I
G
A
K
P
E
-
D
F
D
L
M
A
E
N
A
L
K
D
G
N
A
F
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
Y
8
PsiBlast_PDB
75.28
31%
-40
- C5 -
-
1RRM
2
FUCO_ECOLI
A:
[15-383]
----------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
-
V
M
G
V
K
V
E
G
M
S
L
E
E
A
R
-
N
A
--
A
V
E
A
V
F
A
L
N
R
D
-----
V
G
I
P
P
H
L
R
D
V
G
-
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
7
PsiBlast_PDB
75.19
31%
-42
- C5 -
-
5BR4
3
FUCO_ECOLI
A:
[15-383]
----------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
-
G
V
K
V
E
G
M
S
L
E
E
A
R
-
N
A
--
A
V
E
A
V
F
A
L
N
R
D
-----
V
G
I
P
P
H
L
R
D
V
G
-
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
46
PsiBlast_CBE
74.70
31%
-40
- C5 -
-
2BL4
1
FUCO_ECOLI
B:
[24-392]
----------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
-
G
V
K
V
E
G
M
S
L
E
E
A
R
-
N
A
--
A
V
E
A
V
F
A
L
N
R
D
-----
V
G
I
P
P
H
L
R
D
V
G
-
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
48
PsiBlast_CBE
74.57
31%
-39
- C5 -
-
5BR4
3
FUCO_ECOLI
B:
[15-383]
----------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
C
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
-
G
V
K
V
E
G
M
S
L
E
E
A
R
-
N
A
--
A
V
E
A
V
F
A
L
N
R
D
-----
V
G
I
P
P
H
L
R
D
V
G
-
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
6
PsiBlast_PDB
74.44
31%
-36
- C5 -
-
2BL4
1
FUCO_ECOLI
A:
[24-392]
----------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
-
G
V
K
V
E
G
M
S
L
E
E
A
R
-
N
A
--
A
V
E
A
V
F
A
L
N
R
D
-----
V
G
I
P
P
H
L
R
D
V
G
-
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
64
HHSearch
74.30
32%
1
- C5 -
-
4FR2
-
?
A:
[16-398]
----
A
Y
D
F
L
M
P
S
V
N
F
F
G
P
G
V
I
S
K
I
G
E
R
A
K
M
L
G
M
K
K
P
V
I
V
T
D
K
F
-
L
E
N
L
K
-
N
G
A
V
A
Q
T
L
A
S
L
--
K
K
S
-
G
V
D
Y
V
V
Y
N
G
V
E
P
N
P
K
I
H
N
I
K
E
V
K
T
L
Y
E
K
E
D
A
D
S
I
I
T
V
G
G
G
S
A
H
D
T
G
K
G
A
G
I
I
M
T
N
G
--
D
D
I
T
K
L
A
G
I
E
T
L
K
N
P
L
P
P
L
I
A
V
N
T
T
A
G
T
G
S
E
L
T
R
H
A
V
I
T
N
E
E
T
H
L
K
F
V
V
V
S
W
R
N
I
P
L
V
S
F
N
D
P
T
L
M
L
D
I
P
K
G
L
T
A
A
T
G
M
D
A
F
V
Q
A
V
E
P
Y
V
S
V
D
H
N
P
I
T
D
S
Q
C
I
Q
A
I
K
L
I
E
S
S
L
R
E
A
V
A
N
G
H
N
L
Q
A
R
T
K
M
V
E
A
E
M
L
A
G
M
A
F
N
N
A
N
L
G
Y
V
H
A
M
A
H
Q
L
G
G
Q
Y
D
A
P
H
G
V
C
C
A
L
L
L
P
Y
A
E
E
Y
N
L
I
A
D
P
E
R
F
A
E
-
L
A
R
I
M
G
E
N
T
D
G
-
L
S
T
R
D
A
A
E
L
--
S
I
K
A
M
K
Q
L
-
S
E
---
D
V
G
-
I
P
H
S
I
K
D
I
G
A
-
K
P
E
D
F
D
L
M
A
E
N
A
L
K
D
G
N
A
F
S
N
P
R
K
G
T
K
E
D
I
V
K
I
F
Q
E
A
Y
5
PsiBlast_PDB
73.36
31%
-36
- C5 -
-
2BI4
1
FUCO_ECOLI
A:
[24-392]
----------------
G
R
G
A
V
G
A
L
T
D
E
V
K
R
R
G
Y
Q
K
A
L
I
V
T
D
K
T
-
L
V
--
Q
-
C
G
V
V
A
K
V
T
D
K
M
--
D
A
A
-
G
L
A
W
A
I
Y
D
G
V
V
P
N
P
T
I
T
V
V
K
E
G
L
G
V
F
Q
N
S
G
A
D
Y
L
I
A
I
G
G
G
S
P
Q
D
T
C
K
A
I
G
I
I
S
N
N
P
E
F
A
D
V
R
S
L
E
G
L
S
P
T
N
K
P
S
V
P
I
L
A
I
P
T
T
A
G
T
A
A
E
V
T
I
N
Y
V
I
T
D
E
E
K
R
R
K
F
V
C
V
D
P
H
D
I
P
Q
V
A
F
I
D
A
D
M
M
D
G
M
P
P
A
L
K
A
A
T
G
V
D
A
L
T
H
A
I
E
G
Y
I
T
R
G
A
W
A
L
T
D
A
L
H
I
K
A
I
E
I
I
A
G
A
L
R
G
S
V
A
G
D
K
D
A
G
E
E
M
A
L
G
Q
--
Y
V
A
G
M
G
F
S
N
V
G
L
G
L
V
H
G
M
A
H
P
L
G
A
F
Y
N
T
P
H
G
V
A
N
A
I
L
L
P
H
V
M
R
Y
N
A
D
F
T
G
E
K
Y
R
D
I
A
R
V
M
-
G
V
K
V
E
G
M
S
L
E
E
A
R
-
N
A
--
A
V
E
A
V
F
A
L
N
R
D
-----
V
G
I
P
P
H
L
R
D
V
G
-
V
R
K
E
D
I
P
A
L
A
Q
A
A
L
D
D
V
C
T
G
G
N
P
R
E
A
T
L
E
D
I
V
E
L
Y
H
T
A
W
69
HHSearch
73.34
30%
-34
- C5 -
-
1O2D
2
?
A:
[14-369]
-----
W
E
F
Y
M
P
T
D
V
F
F
G
E
K
I
L
E
K
R
G
N
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I
D
L
L
-
G
K
R
A
L
V
V
T
G
K
S
S
S
K
--
K
-
N
G
S
L
D
D
L
K
K
L
L
--
D
E
T
-
E
I
S
Y
E
I
F
D
E
V
E
E
N
P
S
F
D
N
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A
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Y
R
N
D
S
F
D
F
V
V
G
L
G
G
G
S
P
M
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A
K
A
V
A
V
L
L
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-
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L
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D
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-
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Y
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I
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-
G
N
K
R
G
C
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--
L
M
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P
V
Y
A
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D
P
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Y
T
Y
S
M
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D
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L
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L
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T
G
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A
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H
A
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D
A
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A
I
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A
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K
I
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N
L
P
K
A
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--
N
R
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A
R
K
K
M
F
V
A
S
C
L
A
G
M
V
I
A
Q
T
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T
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A
H
A
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G
Y
P
L
T
T
E
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G
I
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H
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A
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L
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F
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V
M
K
E
E
I
P
E
K
V
D
T
-
V
N
H
I
F
G
G
S
-------------------
L
L
K
F
-
L
K
---
E
L
G
-
L
Y
E
K
---
V
A
V
-
S
S
E
E
L
E
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W
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L