@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSK7: (2017-12-08 )
MQEVADALRLDTELSADSAAYIEELYEQYLTSPTSVAEDWRQYFDKYPKGDQPHSAVREQFLLLGRNANRVQPVVQSTVSTEHERRQIGVLQLIAAYRNRGHQKAKLDPLGLAKREDIPDLDLSAHGLTKSDLDTVFNTGNLEIGKSEATLAEMIEAMEAIYCGSIGVEYMHIVDTKEKRWIQQRLESARGKFNFSNEQKKGFLERLTAAEGLEKYLGNKYVGAKRFGVEGGESFIPMVNEIIQRAGAVGCKEVVIGMPHRGRLNLLVNIMGKNPADLFGEFEGKALHKKGSGDVKYHQGFSSNVMTPGGEVHLALAFNPSHLEIVGPVVEGSVRARQVRRRDIGGDDVLPVIVHGDAAFAGQGVNMETFQMSQTRGYTVGGTVHIIVNNQVGFTTSDPRDARSTEYCTDVAKMIQAPIFHVNGDDPEAVIFATQLAHDFRHEFRKDVVIDLFCYRRRGHNEADEPSGTQPLMYQVIAKKATTRTLYADQLVQEKVLDRAEADQMVEDYRADLEAGNHVANALILEPNTKMFVDWTPYLGHEYTDDWDTSFDINRLKELGEGMSKLPEGFVMQRQVQKVIEDRVKMQTGETPLNWGAAETLAYATLLDEDYLVRITGEDVGRGTFSHRHAKLHNQVDGSTYIPLCHVKENQPRFAIYDSLLSEEAVLAFEYGYATTIPKSLIIWEAQFGDFVNCAQVVIDQFIASGETKWERVCGLTMLLPHGFEGQGPEHSSARLERFLQLCAEDNMQVITPTTPAQIFHALRRQAVRPIRKPLIVMSPKSLLRHKLATSTLEELAHGSFQTVIDEIDQINKSDVTRLVLCGGKVYYDLLEKRREQNLTNVAIVRIEQLYPYPEQRLAEILAAYPNVKELVWAQEEPKNQGAWLFIAPHLYDDILKSGKQIRISFAGREASAAPACGSPYLHAKQQAQLINDALAIEAEQSGDSQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110--.....--..120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280...--....--290.......300......--.310.--........320.......330......--.340---....-----....---.350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......-520--..---.....530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......------650------.......660.......670.......680.......690.......700.......710-.........720...-....730.......740.......750.......760.......770.......780.......790.......800...----...----.810--.........820.......830.....--..840.......850.......860.......870.......880...---....890.......900.......910.......920.......930.......940....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
Q
E
V
A
D
A
L
RLDTELSA
D
S
A
A
Y
I
E
E
L
Y
E
Q
YLTSP
T
S
V
A
E
D
W
R
Q
Y
F
D
KYPKGDQ
P
H
S
A
V
R
E
Q
F
L
L
LGRNA
N
R
V
Q
P
V
V
Q
S
T
VS
T
E
H
E
R
R
Q
I
G
V
L
Q
L
I
A
A
Y
R
NRGHQKAKLDPLGL--AKRED--IPDLDLSAHGL
T
K
S
D
L
D
T
V
FNTGN
L
E
IGKSE
A
T
L
A
E
M
I
E
A
M
E
A
I
Y
CGSIG
V
E
Y
M
H
IVDT
K
E
K
R
W
I
Q
Q
R
L
E
SARGKFNFS
N
E
Q
K
K
G
F
L
E
R
L
T
A
A
E
G
L
E
K
Y
LGNKYVG
A
K
RFGVEG
G
E
S
F
I
P
M
V
N
E
I
I
Q
R
AGAV
G
C
K
E
V
VIGMPHRGR
L
N
L
L
V
NIMGK
N
P
A
D
L
F
G
EFEG
K
--
A
LHK--KGSGD
V
K
Y
HQGFSSNVMTP--GG--
E
--
V
H
L
A
L
A
FNPS
H
L
E
I
V
G
PVVEG
S
V
R
A
R
Q
--
V
R
-----
R
RDI-----GGDD---
V
L
P
V
I
V
HGDAAFAGQGV
N
M
E
T
F
Q
MSQTR
G
Y
T
VG
G
T
V
H
I
I
VNNQVGFTTSDPRDAR
S
T
E
Y
C
T
D
V
A
K
M
IQA
P
I
F
H
VNGDDP
E
A
V
I
F
A
T
Q
L
A
H
D
F
R
H
E
F
R
K
D
V
V
I
D
L
F
C
Y
R
RRGHNEADEPSGT
Q
P
L
M
Y
Q
V
I
A
KKATT
R
T
L
Y
A
D
Q
L
V
Q
E
K
V
L
D
R
A
E
A
D
Q
M
V
E
D
Y
R
A
D
L
EAGNHV-
A
N
A
--
L
I
---LEPN
T
K
M
F
V
DWTPYLGHEYTDDWDTSF
D
I
N
R
L
K
E
L
G
E
G
M
S
KLP
E
G
F
V
M
Q
R
Q
V
Q
K
V
I
E
D
R
V
KMQTGETPLNWG
A
A
E
T
L
A
Y
A
T
LLDE
D
Y
L
V
R
I
TGEDVGRGTFS
H
R
H
A
K
L
HNQVDG
S
T
Y
I
P
L
C
HVKE------NQP------
R
F
A
I
Y
D
S
L
LSEE
A
V
L
A
F
EYGYATTIP
K
S
L
I
I
W
EAQFG
D
F
V
N
C
A
Q
V
V
I
D
Q
F
I
ASGE
T
K
W
---
E
R
VCG
L
T
M
LLPHGFE-GQGPEH
S
S
A
R
L
E
R
F
L
Q
L
C
A
EDN
M
Q
V
ITPT
T
P
A
Q
I
F
H
A
L
R
R
Q
A
V
R
P
IRK
P
L
I
V
M
S
P
K
S
L
L
R
H
K
L
A
T
S
T
L
E
E
L
AHG
S
F
Q
T
V
I
----
D
E
I
----
D
Q----I
N
K
S
D
V
T
R
L
V
LCG
G
K
V
Y
Y
D
L
L
E
K
R
R
EQ--NLT
N
V
A
I
V
R
I
E
Q
LYPY
P
E
Q
R
L
A
E
I
L
A
AYP
N
V
K
E
L
V
WAQEEPKNQG
A
W
L
---
F
I
A
P
H
L
Y
D
D
I
L
KSG
K
Q
I
R
I
S
FAGREASAAPACGSP
Y
L
H
A
K
Q
Q
A
Q
L
IND
A
L
A
I
E
AEQSGDSQ
29
Fugue
92.68
59%
-81
- C2 -
-
2JGD
1
ODO1_ECOLI
A:
[84-933]
---------------------------------------------------------------------------------
D
T
N
V
K
Q
V
K
V
L
Q
L
I
N
A
Y
R
F
R
G
H
Q
H
A
N
L
D
P
L
G
L
--
W
Q
Q
D
D
-----
L
D
P
S
F
H
D
L
T
E
-
D
F
Q
E
T
F
N
V
G
S
F
A
---
E
T
M
K
L
G
E
L
L
E
A
L
K
Q
T
Y
C
G
P
I
G
A
E
Y
M
H
I
T
S
T
E
E
K
R
W
I
Q
Q
R
I
E
S
---
R
A
T
F
N
S
E
E
K
K
R
F
L
S
E
L
T
A
A
E
G
L
E
R
Y
L
G
A
K
F
P
G
--
R
F
S
L
E
G
G
D
A
L
I
P
M
L
K
E
M
I
R
H
A
G
N
S
G
T
R
E
V
V
L
G
M
A
H
R
G
R
L
N
V
L
V
N
V
L
G
K
K
P
Q
D
L
F
D
E
F
A
G
K
----
H
H
--
L
G
T
G
D
V
K
Y
H
M
G
F
S
S
D
F
Q
T
D
--
G
G
--
L
--
V
H
L
A
L
A
F
N
P
S
H
L
E
I
V
S
P
V
V
I
G
S
V
R
A
R
L
--
D
R
-----
L
D
E
P
-----
S
S
N
K
---
V
L
P
I
T
I
H
G
D
A
A
V
T
G
Q
G
V
V
Q
E
T
L
N
M
S
K
A
R
G
Y
E
V
G
G
T
V
R
I
V
I
N
N
Q
---------------
Y
C
T
D
I
G
K
M
V
Q
A
P
I
F
H
V
N
A
D
D
P
E
A
V
A
F
V
T
R
L
A
L
D
F
R
N
T
F
K
R
D
V
F
I
D
L
V
C
Y
R
R
H
-----------
Q
P
L
M
Y
Q
K
I
K
K
H
P
T
P
R
K
I
Y
A
D
K
L
E
Q
E
K
V
A
T
L
E
D
A
T
E
M
V
N
L
Y
R
D
A
L
D
A
G
D
C
V
-
V
A
E
-------
W
R
P
M
N
M
H
S
F
T
W
S
P
Y
L
N
H
E
W
D
E
E
Y
P
N
K
V
E
M
K
R
L
Q
E
L
A
K
R
I
S
T
V
P
E
A
V
E
M
Q
S
R
V
A
K
I
Y
G
D
R
Q
A
M
A
A
G
E
K
L
F
D
W
G
G
A
E
N
L
A
Y
A
T
L
V
D
E
G
I
P
V
R
L
S
G
E
D
S
G
R
G
T
F
F
H
R
H
A
V
I
H
N
Q
S
N
G
S
T
Y
T
P
L
Q
H
I
H
N
------
G
Q
G
------
A
F
R
V
W
D
S
V
L
S
E
E
A
V
L
A
F
E
Y
G
Y
A
T
A
E
P
R
T
L
T
I
W
E
A
Q
F
G
D
F
A
N
G
A
Q
V
V
I
D
Q
F
I
S
S
G
E
Q
K
W
---
G
R
M
C
G
L
V
M
L
L
P
H
G
Y
E
-
G
Q
G
P
E
H
S
S
A
R
L
E
R
Y
L
Q
L
C
A
E
Q
N
M
Q
V
C
V
P
S
T
P
A
Q
V
Y
H
M
L
R
R
Q
A
L
R
G
M
R
R
P
L
V
V
M
S
P
K
S
L
L
R
H
P
L
A
V
S
S
L
E
E
L
A
N
G
T
F
L
P
A
I
----
G
E
I
----
D
E
----
L
D
P
K
G
V
K
R
V
V
M
C
S
G
K
V
Y
Y
D
L
L
E
Q
R
R
K
N
--
N
Q
H
D
V
A
I
V
R
I
E
Q
L
Y
P
F
P
H
K
A
M
Q
E
V
L
Q
Q
F
A
H
V
K
D
F
V
W
C
Q
E
E
P
L
N
Q
G
A
W
Y
---
C
S
Q
H
H
F
R
E
V
I
P
F
G
A
---
S
L
R
Y
A
G
R
P
A
S
A
S
P
A
V
G
H
M
S
V
H
Q
K
Q
Q
Q
D
L
V
N
D
A
L
N
V
E
--------
30
Fugue
78.16
47%
5
- C2 -
-
2YIC
2
KGD_MYCS2
A:
[7-868]
-------------------------------------------------------------------------------------
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
-------------
R
L
D
N
T
R
F
R
S
T
L
W
D
L
D
R
E
F
Q
R
---------
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
--
T
V
A
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
--------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
D
N
D
--
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
--
D
L
L
DTGE
E
G
S
D
-----
N
R
F
S
---
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
---
K
H
L
--------------------
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
E
G
-
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
EEPM
Y
T
D
----
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
---
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
--
G
L
K
R
I
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
1
PsiBlast_PDB
76.40
45%
16
- C2 -
-
2Y0P
3
KGD_MYCS2
A:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
D------------------
L
T
L
W
D
L
D
R
E
F
K
V
D
-----
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN
P
S
Q
A
--
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
P
S
K
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
41
HHSearch
76.13
46%
6
- C2 -
-
2Y0P
3
KGD_MYCS2
C:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
--
D
N
T
R
F
--------
N
S
H
G
L
T
L
W
D
L
D
R
E
F
K
V
D
G
F
A
-
G
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
-
D
-
K
P
T
V
A
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
--
L
N
P
S
QA
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
FG
D
N
--
D
--
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
--
D
L
-----
L
D
T
G
EEGSD
N
R
F
S
---
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
V
R
E
L
EK
H
E
---
I
E
P
S
E
S
V
E
A
D
Q
-
Q
I
P
-----
S
K
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
-
Y
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
NPDGTP
T
G
G
------
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
----
M
Y
TDGE
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
-
Y
Y
E
-
L
A
A
R
K
A
K
E
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
---
S
F
G
L
T
L
P
E
-
I
L
P
D
H
-
F
T
G
L
K
R
I
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
25
PsiBlast_CBE
75.95
45%
17
- C2 -
-
2Y0P
3
KGD_MYCS2
D:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
D-------------------
T
L
W
D
L
D
R
E
F
K
---------
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN------
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
P
S
K
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
M
Y
T
D
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
24
PsiBlast_CBE
75.50
45%
22
- C2 -
-
2YID
2
KGD_MYCS2
D:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
R
-------------
L
T
L
W
D
L
D
R
E
F
K
V
D
G
---
G
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN
P
S
Q
A
--
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
P
--
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
27
PsiBlast_CBE
75.32
45%
21
- C2 -
-
2XTA
2
KGD_MYCS2
B:
[6-868]
------------------------------------------------------------------------------------
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
R
--------------
T
L
W
D
L
D
R
E
F
K
V
------
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
----------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K------------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
26
PsiBlast_CBE
75.27
45%
22
- C2 -
-
2Y0P
3
KGD_MYCS2
C:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
----------
N
S
H
G
L
T
L
W
D
L
D
R
E
F
K
V
D
G
F
-
A
G
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN
P
S
Q
A
--
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
P
S
K
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
21
PsiBlast_CBE
75.23
45%
22
- C2 -
-
3ZHU
2
KGD_MYCS2
D:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
R
-------------
L
T
L
W
D
L
D
R
E
F
K
V
D
G
---
G
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN
P
S
Q
A
--
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
P
--
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
40
HHSearch
74.90
46%
17
- C2 -
-
2YIC
2
KGD_MYCS2
A:
[7-868]
-------------------------------------------------------------------------------------
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
--
D
N
T
R
F
RS-----------
T
L
W
D
L
D
R
E
F
---------
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
-
D
-
K
P
T
V
A
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
--------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
FG
D
N
--
D
--
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
--
D
L
-----
L
D
T
G
EEGSD
N
R
F
S
---
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
V
R
E
L
E
K
H
--------------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
-
Y
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
NPDGTP
T
G
G
------
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
----
M
Y
TDGE
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
-
Y
Y
E
-
L
A
A
R
K
A
K
E
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
---
S
F
G
L
T
L
P
E
-
I
L
P
D
H
-
F
T
G
L
K
R
I
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
22
PsiBlast_CBE
74.78
45%
19
- C2 -
-
3ZHT
2
KGD_MYCS2
D:
[8-868]
--------------------------------------------------------------------------------------
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
-----------------
W
D
L
D
R
E
F
-----------
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
----------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
---------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
3
PsiBlast_PDB
74.75
45%
26
- C2 -
-
2YID
2
KGD_MYCS2
A:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
---------------
L
T
L
W
D
L
D
R
E
F
K
V
D
-----
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN
P
S
Q
A
--
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
---
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
---
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
2
PsiBlast_PDB
74.62
45%
25
- C2 -
-
2YIC
2
KGD_MYCS2
A:
[7-868]
-------------------------------------------------------------------------------------
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
R
S
-------------
T
L
W
D
L
D
R
E
F
---------
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
--------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H-----------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
4
PsiBlast_PDB
74.50
45%
25
- C2 -
-
3ZHT
2
KGD_MYCS2
A:
[7-868]
-------------------------------------------------------------------------------------
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
R
S
-------------
T
L
W
D
L
D
R
E
F
---------
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
--------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H-----------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
5
PsiBlast_PDB
74.48
45%
21
- C2 -
-
3ZHU
2
KGD_MYCS2
A:
[5-868]
-----------------------------------------------------------------------------------
E
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
---------------
L
T
L
W
D
L
D
R
E
F
K
V
D
-----
V
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
E
G
N
LN
P
S
Q
A
--
H
G
S
G
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H
E
I
E
P
S
E
S
V
E
A
D
------
Q
Q
I
---
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
23
PsiBlast_CBE
74.25
45%
24
- C2 -
-
3ZHT
2
KGD_MYCS2
B:
[6-868]
------------------------------------------------------------------------------------
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
-----------------
W
D
L
D
R
E
F
K
---------
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
----------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
H
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H-----------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
28
PsiBlast_CBE
73.65
45%
23
- C2 -
-
3ZHQ
2
KGD_MYCS2
B:
[6-868]
------------------------------------------------------------------------------------
D
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
-----------------
W
D
L
D
R
E
F
----------
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
----------------
D
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
A
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H-----------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
6
PsiBlast_PDB
73.54
45%
26
- C2 -
-
3ZHQ
2
KGD_MYCS2
A:
[7-868]
-------------------------------------------------------------------------------------
K
N
A
R
V
I
E
L
I
A
A
Y
R
N
R
G
H
L
M
A
D
I
D
P
L
R
L
DN
T
R
F
R
---------------
L
W
D
L
D
R
E
F
K
--------
Q
R
K
K
L
R
D
I
L
S
V
L
R
D
A
Y
C
R
H
V
G
V
E
Y
T
H
I
L
E
P
E
Q
Q
R
W
I
Q
E
R
V
E
T
K
H
D
K
P
T
V
A
--
E
Q
K
Y
I
L
S
K
L
N
A
A
E
A
F
E
T
F
L
Q
T
K
Y
V
G
Q
K
R
F
S
L
E
G
A
E
T
V
I
P
M
M
D
A
V
I
D
Q
C
A
E
H
G
L
D
E
V
V
I
A
M
P
H
R
G
R
L
N
V
L
A
N
I
V
G
K
P
Y
S
Q
I
F
S
E
F
----------------
V
K
Y
H
L
G
A
T
G
T
Y
I
Q
M
--
F
G
--
D
N
D
I
E
V
S
L
T
A
N
P
S
H
L
E
A
V
D
P
V
L
E
G
L
V
R
A
K
Q
D
L
L
D
-----
T
G
E
E
-----
G
S
D
N
RFS
V
V
P
L
M
L
H
G
D
A
A
F
A
G
Q
G
V
V
A
E
T
L
N
L
A
L
L
R
G
Y
R
T
G
G
T
I
H
I
V
V
N
N
Q
I
G
F
T
T
A
-
P
T
D
S
R
S
S
E
Y
C
T
D
V
A
K
M
I
G
A
P
I
F
H
V
N
G
D
D
P
E
A
C
A
W
V
A
R
L
A
V
D
F
R
Q
A
F
K
K
D
V
V
I
D
M
L
C
Y
R
R
R
G
A
N
E
G
D
D
P
S
M
T
Q
P
Y
M
Y
D
V
I
D
T
K
R
G
S
R
K
A
Y
T
E
A
L
I
G
R
G
D
I
S
M
K
E
A
E
D
A
L
R
D
Y
Q
G
Q
L
E
R
V
F
N
E
-
V
R
E
--
L
E
K
H-----------------------
L
A
T
A
V
D
K
A
M
L
Q
R
I
G
D
A
H
L
A
L
P
E
G
F
T
V
H
P
R
V
R
P
V
L
E
K
R
R
E
M
A
Y
-
E
G
R
I
D
W
A
F
A
E
L
L
A
L
G
S
L
I
A
E
G
K
L
V
R
L
S
G
Q
D
T
Q
R
G
T
F
T
Q
R
H
A
V
I
V
D
R
K
T
G
E
E
F
T
P
L
Q
L
L
A
T
------
N
P
D
GTPTG
G
K
F
L
V
Y
N
S
A
L
S
E
F
A
A
V
G
F
E
Y
G
Y
S
V
G
N
P
D
A
M
V
L
W
E
A
Q
F
G
D
F
V
N
G
A
Q
S
I
I
D
E
F
I
S
S
G
E
A
K
W
---
G
Q
L
S
D
V
V
L
L
L
P
H
G
H
E
-
G
Q
G
P
D
H
T
S
G
R
I
E
R
F
L
Q
L
W
A
E
G
S
M
T
I
A
M
P
S
T
P
A
N
Y
F
H
L
L
R
R
H
G
K
D
G
I
Q
R
P
L
I
V
F
T
P
K
S
M
L
R
N
K
A
A
V
S
D
I
R
D
F
T
E
S
K
F
R
S
V
L
----
E
E
P
MYTD
G
E
----
G
D
R
N
K
V
T
R
L
L
L
T
S
G
K
I
Y
Y
E
L
A
A
R
K
A
K
E
--
N
R
E
D
V
A
I
V
R
I
E
Q
L
A
P
L
P
R
R
R
L
A
E
T
L
D
R
Y
P
N
V
K
E
K
F
W
V
Q
E
E
P
A
N
Q
G
A
W
P
S
F
G
L
T
L
P
E
I
L
P
D
H
F
T
G
L
K
R
I
-----
S
R
R
A
M
S
A
P
S
S
G
S
S
K
V
H
A
V
E
Q
Q
E
I
L
D
T
A
F
G
----------
7
PsiBlast_PDB
39.84
25%
-132
- C2 -
-
3EXI
-
ODPA_HUMAN
A:
[177-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
K
D
---
E
V
C
L
T
L
Y
G
D
G
A
-
A
N
Q
G
Q
I
F
E
A
Y
N
M
A
A
L
W
K
L
P
C
---
I
F
I
C
E
N
N
R
-------------
T
D
Y
---
Y
K
R
G
D
F
I
P
G
L
R
V
D
G
M
D
I
L
C
V
R
E
A
T
R
F
A
A
A
Y
C
R
S
G
K
G
P
I
L
M
E
L
Q
T
Y
-------------------------
S
D
P
I
M
L
L
K
D
R
M
V
N
S
N
L
A
S
V
E
E
L
K
E
I
D
V
E
V
R
K
E
I
E
D
A
A
Q
F
-
A
T
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
38.98
26%
-89
- C2 -
-
1DTW
-
ODBB_HUMAN
B:
[17-204]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
T
Q
K
M
N
L
F
Q
S
V
T
S
A
L
D
N
S
L
A
K
D
P
T
A
V
I
F
G
E
D
V
A
-
F
G
G
V
F
R
C
T
V
G
L
R
D
K
Y
G
K
------------------
D
------
R
--
V
F
N
T
P
L
C
E
Q
G
I
V
G
F
G
I
G
I
A
V
T
--
G
A
T
A
I
A
E
I
Q
F
A
D
Y
I
F
P
A
F
D
Q
I
V
N
E
A
A
K
Y
R
Y
R
S
G
DL
F
N
C
G
S
L
T
I
R
S
P
W
G
C
V
G
H
G
A
L
Y
H
S
Q
S
-
P
E
A
F
F
A
--
H
C
P
G
I
K
V
V
I
P
R
S
P
F
Q
A
K
G
L
L
L
-
S
C
I
E
D
K
-
N
P
C
I
F
F
E
P
K
I
L
Y
R
A
A
-------------
A
E
E
V
P
----
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------