@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSK9: (2017-12-09 )
MSQQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLDSSHRYEDTVHHLADHGITTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKGTGKLLAGKKVEFVPHEGETQILEPKYVILASGSVPVNIPVAPVDQDIIVDSTGALNFPEVPKRLGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMADKALSKEYQKILTKQGLDIRIGAKVSGTEVNGREVTVKYTQGGEDKEQTFDKLIVCVGRKAYAEGLLAEDSGIKLTERGLVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERIHGHAAQINYDTIISVIYTHPEAAWVGLTEEQAKEKGHEVKTGQFGFAVNGRALAAGEGAGFVKFVADEKTDRLLGMHVIGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSEVVHEAALAVDGRAIHAIQRKRK
Atome Classification :
(41 SA)
.........10........20........30....-..-.-.40........50........60........70.--.--.....-.80..-.......90........100.......110.......120.......130....------...140.......150.......160-.--.......170.....-.-.180.......190.......200.......210.......220.......230-.-......240.....--..--250----.......--260....---.....270.......280.......290.......300.......310.......320-........330.......340-.........350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSQ
Q
F
D
L
V
V
IGGGP
G
G
Y
E
A
A
I
R
A
A
Q
LGF
K
V
A
C
I
E
K
-
R
I-H-NGKPSLG
G
T
C
L
NVGCI
P
S
K
A
LLDSSHR
Y
E
D
T
V
H
H
--
L
--
A
DHGI-TT-GE-
V
N
F
D
L
A
K
L
L
A
R
K
D
K
I
V
D
Q
L
T
G
G
I
D
Q
L
L
KGNGIEWLKGTGKLLAG
K
K
V
E
F
VPHEG------E
T
Q
I
LE
P
K
Y
V
I
L
ASGS
V
P
V
NIPVAP--V--DQ
D
I
I
VDSTGALNFP-
E
-
V
P
K
R
LGVIGA
G
V
I
G
L
E
L
G
S
V
W
R
R
LGA
E
V
V
V
F
E
A
M
D
A
F
L
P
M
A
D
K
A
L
S
K
E
Y
Q
K
I
L
T
-K-QGL
D
I
R
IG
A
K
V
SGT--EV--NG
R
----
E
V
T
V
K
YT--Q--GGE
D
---
K
E
Q
T
F
D
K
L
I
V
C
VG
R
K
A
Y
AEGLLAEDSG
I
K
L
TERG
L
V
EVNDHC
A
T
S
V
E
G
V
Y
A
I
G
D
L
V-R-
G
P
M
L
A
H
K
A
M
E
E
G
V
M
A
V
E
R
I---HGH
A
A
Q
I
N
Y
D
T
I
I
S
V
I
YTHPE
A
A
W
VGL
T
E
E
Q
A
K
EKGHEVKTG
Q
F
G
F
A
VN
G
R
A
L
AAGEGA
G
F
V
K
F
VADEKTD
R
L
L
G
M
H
VIGP
A
A
S
D
I
V
H
Q
G
M
I
A
L
E
F
V
S
SVED
L
Q
L
M
TFGHP
T
F
S
E
V
V
H
E
A
A
LAVDG
R
A
I
H
A
I
Q
RKRK
1
PsiBlast_PDB
86.40
63%
-21
- C1 -
-
5TR3
3
?
A:
[4-477]
M
T
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
T
-
D
A
E
G
K
L
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
W
K
Y
K
E
A
K
E
S
--
F
--
N
V
H
G
I
-
S
T
-
G
E
-
V
K
M
D
V
A
A
M
V
G
R
K
A
G
I
V
K
N
L
T
G
G
V
A
T
L
F
K
A
N
G
V
T
S
I
Q
G
H
G
K
L
L
A
G
K
K
V
E
V
T
K
A
D
G
------
T
T
E
V
I
E
A
E
N
V
I
L
A
S
G
S
R
P
I
D
I
P
P
A
P
--
V
--
D
Q
N
V
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
R
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
T
F
L
M
A
A
D
T
A
V
S
K
E
A
Q
K
T
L
T
-
K
-
Q
G
L
D
I
K
L
G
A
R
V
T
G
S
--
K
V
--
N
G
N
----
E
V
E
V
T
Y
T
--
N
--
A
E
G
E
---
Q
K
I
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
S
D
S
G
V
T
I
D
E
R
G
Y
I
F
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
M
M
L
A
H
K
A
S
E
E
G
I
M
V
V
E
R
I
---
K
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
A
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
G
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
G
A
I
H
V
A
N
----
21
PsiBlast_CBE
85.73
63%
-21
- C1 -
-
5TR3
4
?
B:
[4-477]
M
T
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
T
-
D
A
E
G
K
L
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
W
K
Y
K
E
A
K
E
S
--
F
--
N
V
H
G
I
-
S
T
-
G
E
-
V
K
M
D
V
A
A
M
V
G
R
K
A
G
I
V
K
N
L
T
G
G
V
A
T
L
F
K
A
N
G
V
T
S
I
Q
G
H
G
K
L
L
A
G
K
K
V
E
V
T
K
A
D
G
------
T
T
E
V
I
E
A
E
N
V
I
L
A
S
G
S
R
P
I
D
I
P
P
A
P
--
V
--
D
Q
N
V
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
R
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
T
F
L
M
A
A
D
T
A
V
S
K
E
A
Q
K
T
L
T
-
K
-
Q
G
L
D
I
K
L
G
A
R
V
T
G
S
--
K
V
--
N
G
N
----
E
V
E
V
T
Y
T
--
N
--
A
E
G
E
---
Q
K
I
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
S
D
S
G
V
T
I
D
E
R
G
Y
I
F
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
M
M
L
A
H
K
A
S
E
E
G
I
M
V
V
E
R
I
---
K
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
A
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
G
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
G
A
I
H
V
A
N
----
32
PsiBlast_CBE
84.80
61%
-19
- C1 -
-
1LPF
2
DLDH_PSEFL
B:
[1-472]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
-----
4
PsiBlast_PDB
84.04
61%
-19
- C1 -
-
5U8V
13
?
A:
[6-477]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
6
PsiBlast_PDB
83.99
61%
-20
- C1 -
-
1LPF
2
DLDH_PSEFL
A:
[1-472]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
S
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
-----
23
PsiBlast_CBE
83.83
61%
-20
- C1 -
-
5U8W
8
?
D:
[6-477]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
86
PsiBlast_CBE
83.09
43%
-120
- C1 -
-
1EBD
2
DLDH1_GEOSE
B:
[3-451]
---
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
--------
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
H
--
S
--
E
E
M
G
I
-
K
A
-
E
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
D
-------
S
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
R
I
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
-
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
--
E
E
--
R
E
D
----
G
V
T
V
T
Y
E
--
A
--
N
G
E
T
---
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
-
P
-
G
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
---
A
G
H
P
S
A
V
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------------
3
PsiBlast_PDB
82.85
61%
-16
- C1 -
-
5U8U
12
DLDH2_PSEAE
A:
[6-477]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
5
PsiBlast_PDB
82.60
61%
-17
- C1 -
-
5U8W
11
?
A:
[5-477]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
28
PsiBlast_CBE
82.26
61%
-17
- C1 -
-
5U8V
14
?
B:
[5-477]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
27
PsiBlast_CBE
82.25
61%
-18
- C1 -
-
5U8V
2
?
C:
[5-478]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
R
---
26
PsiBlast_CBE
82.25
61%
-14
- C1 -
-
5U8V
5
?
D:
[4-477]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
87
PsiBlast_CBE
82.09
43%
-123
- C1 -
-
1EBD
2
DLDH1_GEOSE
A:
[3-451]
---
E
T
E
T
L
V
V
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
Q
K
V
T
I
V
E
K
-
G
--------
N
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
I
S
A
S
H
R
Y
E
Q
A
-
K
H
--
S
--
E
E
M
G
I
-
K
A
-
E
N
-
V
T
I
D
F
A
K
V
Q
E
W
K
A
S
V
V
K
K
L
T
G
G
V
E
G
L
L
K
G
N
K
V
E
I
V
K
G
E
A
Y
F
V
D
A
N
T
V
R
V
V
N
G
D
-------
S
A
Q
T
Y
T
F
K
N
A
I
I
A
T
G
S
R
P
I
E
L
P
N
F
K
--
F
--
S
N
R
I
L
-
D
S
T
G
A
L
N
L
G
-
E
-
V
P
K
S
L
V
V
I
G
G
G
Y
I
G
I
E
L
G
T
A
Y
A
N
F
G
T
K
V
T
I
L
E
G
A
G
E
I
L
S
G
F
E
K
Q
M
A
A
I
I
K
K
R
L
K
-
K
-
K
G
V
E
V
V
T
N
A
L
A
K
G
A
--
E
E
--
R
E
D
----
G
V
T
V
T
Y
E
--
A
--
N
G
E
T
---
K
T
I
D
A
D
Y
V
L
V
T
V
G
R
R
P
N
T
D
E
L
G
L
E
Q
I
G
I
K
M
T
N
R
G
L
I
E
V
D
Q
Q
C
R
T
S
V
P
N
I
F
A
I
G
D
I
V
-
P
-
G
P
A
L
A
H
K
A
S
Y
E
G
K
V
A
A
E
A
I
---
A
G
H
P
S
A
V
D
Y
V
A
I
P
A
V
V
F
S
D
P
E
C
A
S
V
G
Y
F
E
Q
Q
A
K
D
E
G
I
D
V
I
A
A
K
F
P
F
A
A
N
G
R
A
L
A
L
N
D
T
D
G
F
L
K
L
V
V
R
K
E
D
G
V
I
I
G
A
Q
I
I
G
P
N
A
S
D
M
I
A
E
L
G
L
A
I
E
A
G
M
T
A
E
D
I
A
L
T
I
H
A
H
P
T
L
G
E
I
A
M
E
A
A
----------------
31
PsiBlast_CBE
82.02
61%
-16
- C1 -
-
5U8U
17
DLDH2_PSEAE
B:
[4-477]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
118
HHSearch
81.76
62%
-15
- C1 -
-
5U8U
4
DLDH2_PSEAE
D:
[4-478]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
-
G
K
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
R
---
22
PsiBlast_CBE
81.72
62%
-18
- C1 -
-
3LAD
2
DLDH_AZOVI
B:
[1-472]
-
S
Q
K
F
D
V
I
V
I
G
A
G
P
G
G
Y
V
A
A
I
K
S
A
Q
L
G
L
K
T
A
L
I
E
K
Y
K
G
-
K
-
E
G
K
T
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
F
H
E
A
H
E
S
--
F
--
K
L
H
G
I
-
S
T
-
G
E
-
V
A
I
D
V
P
T
M
I
A
R
K
D
Q
I
V
R
N
L
T
G
G
V
A
S
L
I
K
A
N
G
V
T
L
F
E
G
H
G
K
L
L
A
G
K
K
V
E
V
T
A
A
D
G
------
S
S
Q
V
L
D
T
E
N
V
I
L
A
S
G
S
K
P
V
E
I
P
P
A
P
--
V
--
D
Q
D
V
I
V
D
S
T
G
A
L
D
F
Q
-
N
-
V
P
G
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
M
D
K
F
L
P
A
V
D
E
Q
V
A
K
E
A
Q
K
I
L
T
-
K
-
Q
G
L
K
I
L
L
G
A
R
V
T
G
T
--
E
V
--
K
N
K
----
Q
V
T
V
K
F
V
--
D
--
A
E
G
E
---
K
S
Q
A
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
Y
C
A
T
S
V
P
G
V
Y
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
V
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
A
V
I
Y
T
H
P
E
I
A
G
V
G
K
T
E
Q
A
L
K
A
E
G
V
A
I
N
V
G
V
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
A
G
F
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
A
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
A
H
P
A
L
S
E
A
L
H
E
A
A
L
A
V
S
G
H
A
I
H
V
A
-----
24
PsiBlast_CBE
81.67
61%
-15
- C1 -
-
5U8W
7
?
C:
[5-477]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
25
PsiBlast_CBE
81.52
61%
-14
- C1 -
-
5U8W
11
?
B:
[5-477]
-
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
----
29
PsiBlast_CBE
81.28
61%
-14
- C1 -
-
5U8U
4
DLDH2_PSEAE
D:
[4-478]
M
S
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
R
---
30
PsiBlast_CBE
81.08
61%
-18
- C1 -
-
5U8U
4
DLDH2_PSEAE
C:
[6-478]
--
Q
K
F
D
V
V
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
L
K
T
A
C
I
E
K
-
Y
I
G
K
-
E
G
K
V
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
D
S
S
Y
K
Y
H
E
A
K
E
A
--
F
--
K
V
H
G
I
-
E
A
-
K
G
-
V
T
I
D
V
P
A
M
V
A
R
K
A
N
I
V
K
N
L
T
G
G
I
A
T
L
F
K
A
N
G
V
T
S
F
E
G
H
G
K
L
L
A
N
K
Q
V
E
V
T
G
L
D
G
------
K
T
Q
V
L
E
A
E
N
V
I
I
A
S
G
S
R
P
V
E
I
P
P
A
P
--
L
--
T
D
D
I
I
V
D
S
T
G
A
L
E
F
Q
-
A
-
V
P
K
K
L
G
V
I
G
A
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
L
E
A
L
D
K
F
L
P
A
A
D
E
Q
I
A
K
E
A
L
K
V
L
T
-
K
-
Q
G
L
N
I
R
L
G
A
R
V
T
A
S
--
E
V
--
K
K
K
----
Q
V
T
V
T
F
T
--
D
--
A
N
G
E
---
Q
K
E
T
F
D
K
L
I
V
A
V
G
R
R
P
V
T
T
D
L
L
A
A
D
S
G
V
T
L
D
E
R
G
F
I
Y
V
D
D
H
C
K
T
S
V
P
G
V
F
A
I
G
D
V
V
-
R
-
G
A
M
L
A
H
K
A
S
E
E
G
V
M
V
A
E
R
I
---
A
G
H
K
A
Q
M
N
Y
D
L
I
P
S
V
I
Y
T
H
P
E
I
A
W
V
G
K
T
E
Q
T
L
K
A
E
G
V
E
V
N
V
G
T
F
P
F
A
A
S
G
R
A
M
A
A
N
D
T
T
G
L
V
K
V
I
A
D
A
K
T
D
R
V
L
G
V
H
V
I
G
P
S
A
A
E
L
V
Q
Q
G
A
I
G
M
E
F
G
T
S
A
E
D
L
G
M
M
V
F
S
H
P
T
L
S
E
A
L
H
E
A
A
L
A
V
N
G
H
A
I
H
I
A
N
R
---
8
PsiBlast_PDB
79.22
48%
-77
- C1 -
-
2YQU
2
?
A:
[2-454]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
--------
E
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
K
K
G
--
L
--
L
--
G
A
-
K
V
-
K
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
------
E
E
--
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
-
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
--
K
G
A
----
R
V
E
L
-----
E
--
G
G
E
V
---
L
E
A
--
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
---
V
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
-------
107
HHSearch
78.75
47%
-40
- C1 -
-
3URH
3
?
B:
[26-490]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
--------
R
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
Q
H
G
--
L
--
E
A
L
G
V
-
E
V
-
A
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
K
G
------
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
VA
F
--
D
E
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
-
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
--
V
K
--
S
G
D
----
G
A
K
V
T
F
E
PV
K
--
G
G
E
A
---
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
---
A
G
Q
A
G
H
V
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
K
P
I
H
-------
33
PsiBlast_CBE
78.55
48%
-75
- C1 -
-
2YQU
2
?
B:
[2-454]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
--------
E
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
K
K
G
--
L
--
L
--
G
A
-
K
V
-
K
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
------
E
E
--
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
-
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
VP
E
A
--
K
G
A
----
R
V
E
L
-----
E
--
G
G
E
V
---
L
E
A
--
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
---
V
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
I
H
-------
7
PsiBlast_PDB
77.43
48%
-73
- C1 -
-
2EQ7
3
?
A:
[2-452]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
--------
E
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
K
K
G
--
L
--
L
--
G
A
-
K
V
-
K
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
------
E
E
--
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
-
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
V
P
E
A
--
K
G
A
----
R
V
E
L
-----
E
--
G
G
E
V
---
L
E
A
--
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
---
V
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---------
108
HHSearch
76.94
47%
-35
- C1 -
-
3URH
2
?
A:
[26-486]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
--------
R
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
Q
H
G
--
L
--
E
A
L
G
V
-
E
V
-
A
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
K
G
------
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
V
A
F
--
D
E
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
-
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
--
V
K
--
S
G
D
----
G
A
K
V
T
F
E
PV
K
--
G
G
E
A
---
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
---
A
G
Q
A
G
H
V
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----------
34
PsiBlast_CBE
76.72
48%
-74
- C1 -
-
2EQ7
3
?
B:
[2-452]
----
Y
D
L
L
V
I
G
A
G
P
G
G
Y
V
A
A
I
R
A
A
Q
L
G
M
K
V
G
V
V
E
K
--------
E
K
A
L
G
G
T
C
L
R
V
G
C
I
P
S
K
A
L
L
E
T
T
E
R
I
Y
E
A
K
K
G
--
L
--
L
--
G
A
-
K
V
-
K
G
-
V
E
L
D
L
P
A
L
M
A
H
K
D
K
V
V
Q
A
N
T
Q
G
V
E
F
L
F
K
K
N
G
I
A
R
H
Q
G
T
A
R
F
L
S
E
R
K
V
-
L
V
E
E
T
G
------
E
E
--
L
E
A
R
Y
I
L
I
A
T
G
S
A
P
L
I
P
P
W
A
Q
--
V
--
D
Y
E
R
V
V
T
S
T
E
A
L
S
F
P
-
E
-
V
P
K
R
L
I
V
V
G
G
G
V
I
G
L
E
L
G
V
V
W
H
R
L
G
A
E
V
I
V
L
E
Y
M
D
R
I
L
P
T
M
D
L
E
V
S
R
A
A
E
R
V
F
K
-
K
-
Q
G
L
T
I
R
T
G
V
R
V
T
A
V
VP
E
A
--
K
G
A
----
R
V
E
L
-----
E
--
G
G
E
V
---
L
E
A
--
D
R
V
L
V
A
V
G
R
R
P
Y
T
E
G
L
S
L
E
N
A
G
L
S
T
D
E
R
G
R
I
P
V
D
E
H
L
R
T
R
V
P
H
I
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
S
E
E
G
I
A
A
V
E
H
M
---
V
R
G
F
G
H
V
D
Y
Q
A
I
P
S
V
V
Y
T
H
P
E
I
A
A
V
G
Y
T
E
E
E
L
K
A
Q
G
I
P
Y
K
V
G
K
F
P
Y
S
A
S
G
R
A
R
A
M
G
E
T
E
G
F
I
K
V
L
A
H
A
K
T
D
R
I
L
G
V
H
G
I
G
A
R
V
G
D
V
L
A
E
A
A
L
A
L
F
F
K
A
S
A
E
D
L
G
R
A
P
H
A
H
P
S
L
S
E
I
L
K
E
A
A
L
A
A
W
E
R
P
---------
15
PsiBlast_PDB
76.53
47%
-35
- C1 -
-
3URH
2
?
A:
[26-486]
----
Y
D
L
I
V
I
G
S
G
P
G
G
Y
V
C
A
I
K
A
A
Q
L
G
M
K
V
A
V
V
E
K
-
R
-------
S
T
Y
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
S
E
M
F
H
Q
A
Q
H
G
--
L
--
E
A
L
G
V
-
E
V
-
A
N
-
P
K
L
N
L
Q
K
M
M
A
H
K
D
A
T
V
K
S
N
V
D
G
V
S
F
L
F
K
K
N
K
I
D
G
F
Q
G
T
G
K
V
L
G
Q
G
K
V
S
V
T
N
E
K
G
------
E
E
Q
V
L
E
A
K
N
V
V
I
A
T
G
S
D
V
A
G
I
P
G
V
E
--
V
A
F
D
E
K
T
I
V
S
S
T
G
A
L
A
L
E
-
K
-
V
P
A
S
M
I
V
V
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
K
V
T
V
V
E
F
L
D
T
I
L
G
G
M
D
G
E
V
A
K
Q
L
Q
R
M
L
T
-
K
-
Q
G
I
D
F
K
L
G
A
K
V
T
G
A
V
K
S
G
--
D
G
A
----
K
V
T
F
E
P
V
--
K
--
G
G
E
A
---
T
T
L
D
A
E
V
V
L
I
A
T
G
R
K
P
S
T
D
G
L
G
L
A
K
A
G
V
V
L
D
S
R
G
R
V
E
I
D
R
H
F
Q
T
S
I
A
G
V
Y
A
I
G
D
V
V
-
R
-
G
P
M
L
A
H
K
A
E
D
E
G
V
A
V
A
E
I
I
---
A
G
Q
A
G
H
V
N
Y
D
V
I
P
G
V
V
Y
T
Q
P
E
V
A
S
V
G
K
T
E
E
E
L
K
A
A
G
V
A
Y
K
I
G
K
F
P
F
T
A
N
G
R
A
R
A
M
L
Q
T
D
G
F
V
K
I
L
A
D
K
E
T
D
R
V
L
G
G
H
I
I
G
F
G
A
G
E
M
I
H
E
I
A
V
L
M
E
F
G
G
S
S
E
D
L
G
R
T
C
H
A
H
P
T
M
S
E
A
V
K
E
A
A
L
S
T
F
F
-----------
16
PsiBlast_PDB
71.02
43%
7
- C1 -
-
1JEH
2
DLDH_YEAST
A:
[2-478]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
-----
G
K
--
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
H
T
E
--
A
--
Q
K
R
G
I
D
V
N
-
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
D
G
LEGTVK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
-
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
--
K
R
--
N
D
D
KNVV
E
I
V
V
E
D
T
--
K
--
T
N
K
Q
---
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
-
F
-
G
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
TG
H
G
H
---
V
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
------
17
PsiBlast_PDB
70.32
43%
9
- C1 -
-
1V59
3
DLDH_YEAST
A:
[2-478]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
-----
G
K
--
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
H
T
E
--
A
--
Q
K
R
G
I
D
V
N
-
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
D
G
LEGTVK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
-
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
--
K
R
--
N
D
D
KN
V
V
E
I
V
V
E
D
T
--
K
--
T
N
K
Q
---
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
-
F
-
G
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
K
TG
H
G
H
---
V
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
------
71
PsiBlast_CBE
69.88
43%
8
- C1 -
-
1V59
3
DLDH_YEAST
B:
[2-478]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
-----
G
K
--
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
H
T
E
--
A
--
Q
K
R
G
I
D
V
N
-
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
D
G
LEGTVK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
-
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
--
K
R
--
N
D
D
KNVV
E
I
V
V
E
D
T
--
K
--
T
N
K
Q
---
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
-
F
-
G
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
KTG
H
G
H
---
V
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
------
72
PsiBlast_CBE
69.66
43%
6
- C1 -
-
1JEH
2
DLDH_YEAST
B:
[2-478]
I
N
K
S
H
D
V
V
I
I
G
G
G
P
A
G
Y
V
A
A
I
K
A
A
Q
L
G
F
N
T
A
C
V
E
K
-
R
-----
G
K
--
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
N
N
S
H
L
F
H
Q
M
H
T
E
--
A
--
Q
K
R
G
I
D
V
N
-
G
D
-
I
K
I
N
V
A
N
F
Q
K
A
K
D
D
A
V
K
Q
L
T
G
G
I
E
L
L
F
K
K
N
K
V
T
Y
Y
K
G
N
G
S
F
E
D
E
T
K
I
R
V
T
P
V
D
G
LEGTVK
E
D
H
I
L
D
V
K
N
I
I
V
A
T
G
S
E
V
T
P
F
P
G
I
E
--
I
--
D
E
E
K
I
V
S
S
T
G
A
L
S
L
K
-
E
-
I
P
K
R
L
T
I
I
G
G
G
I
I
G
L
E
M
G
S
V
Y
S
R
L
G
S
K
V
T
V
V
E
F
Q
P
Q
I
G
A
S
M
D
G
E
V
A
K
A
T
Q
K
F
L
K
-
K
-
Q
G
L
D
F
K
L
S
T
K
V
I
S
A
--
K
R
--
N
D
D
KNVV
E
I
V
V
E
D
T
--
K
--
T
N
K
Q
---
E
N
L
E
A
E
V
L
L
V
A
V
G
R
R
P
Y
I
A
G
L
G
A
E
K
I
G
L
E
V
D
K
R
G
R
L
V
I
D
D
Q
F
N
S
K
F
P
H
I
K
V
V
G
D
V
T
-
F
-
G
P
M
L
A
H
K
A
E
E
E
G
I
A
A
V
E
M
L
KTG
H
G
H
---
V
N
Y
N
N
I
P
S
V
M
Y
S
H
P
E
V
A
W
V
G
K
T
E
E
Q
L
K
E
A
G
I
D
Y
K
I
G
K
F
P
F
A
A
N
S
R
A
K
T
N
Q
D
T
E
G
F
V
K
I
L
I
D
S
K
T
E
R
I
L
G
A
H
I
I
G
P
N
A
G
E
M
I
A
E
A
G
L
A
L
E
Y
G
A
S
A
E
D
V
A
R
V
C
H
A
H
P
T
L
S
E
A
F
K
E
A
N
M
A
A
Y
D
K
A
I
H
C
------
113
HHSearch
69.29
46%
-22
- C1 -
-
2EQ6
2
?
B:
[4-463]
-
M
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
--------
G
-
E
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
E
T
L
H
H
L
K
-
V
--
A
--
E
G
F
G
L
-
K
A
--
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
---
G
--------
G
E
R
Y
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
---
G
E
D
V
W
D
S
T
R
A
L
K
V
E
E
G
-
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
-
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
--
E
K
--
K
K
D
----
G
L
H
V
R
L
E
--
P
AE
G
G
E
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
---
A
G
K
D
S
A
F
D
Y
-
Q
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
N
----
95
PsiBlast_CBE
67.50
38%
-61
- C1 -
-
4JDR
4
DLDH_ECOLI
A:
[9-461]
------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
----
Y
-
N
---
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
E
E
A
-
K
A
--
L
--
A
E
H
G
I
-
V
F
-
G
E
-
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
T
L
E
V
E
G
E
N
G
------
K
T
-
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
-
K
-
K
-
F
N
L
M
L
E
T
K
V
--
T
--
A
V
--
E
A
K
----
E
D
G
I
Y
V
T
--
M
--
E
G
K
K
APA
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
-
G
-
Q
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
---
A
G
K
K
H
Y
F
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
-----------
94
PsiBlast_CBE
67.43
38%
-63
- C1 -
-
4JDR
3
DLDH_ECOLI
B:
[9-461]
------
V
V
V
L
G
A
G
P
A
G
Y
S
A
A
F
R
C
A
D
L
G
L
E
T
V
I
V
E
R
----
Y
-
N
---
T
L
G
G
V
C
L
N
V
G
C
I
P
S
K
A
L
L
H
V
A
K
V
I
E
E
A
-
K
A
--
L
--
A
E
H
G
I
-
V
F
-
G
E
-
P
K
T
D
I
D
K
I
R
T
W
K
E
K
V
I
N
Q
L
T
G
G
L
A
G
M
A
K
G
R
K
V
K
V
V
N
G
L
G
K
F
T
G
A
N
T
L
E
V
E
G
E
N
G
------
K
T
-
V
I
N
F
D
N
A
I
I
A
A
G
S
R
P
I
Q
L
P
F
I
P
--
H
--
E
D
P
R
I
W
D
S
T
D
A
L
E
L
K
-
E
-
V
P
E
R
L
L
V
M
G
G
G
I
I
G
L
E
M
G
T
V
Y
H
A
L
G
S
Q
I
D
V
V
E
M
F
D
Q
V
I
P
A
A
D
K
D
I
V
K
V
F
T
K
R
I
S
-
K
-
K
-
F
N
L
M
L
E
T
K
V
--
T
--
A
V
--
E
A
K
----
E
D
G
I
Y
V
T
--
M
--
E
G
K
K
APA
E
P
Q
R
Y
D
A
V
L
V
A
I
G
R
V
P
N
G
K
N
L
D
A
G
K
A
G
V
E
V
D
D
R
G
F
I
R
V
D
K
Q
L
R
T
N
V
P
H
I
F
A
I
G
D
I
V
-
G
-
Q
P
M
L
A
H
K
G
V
H
E
G
H
V
A
A
E
V
I
---
A
G
K
K
H
Y
F
D
P
K
V
I
P
S
I
A
Y
T
E
P
E
V
A
W
V
G
L
T
E
K
E
A
K
E
K
G
I
S
Y
E
T
A
T
F
P
W
A
A
S
G
R
A
I
A
S
D
C
A
D
G
M
T
K
L
I
F
D
K
E
S
H
R
V
I
G
G
A
I
V
G
T
N
G
G
E
L
L
G
E
I
G
L
A
I
E
M
G
C
D
A
E
D
I
A
L
T
I
H
A
H
P
T
L
H
E
S
V
G
L
A
A
E
V
F
E
G
-----------
110
HHSearch
66.95
43%
12
- C1 -
-
2QAE
2
DLDH_TRYCR
A:
[1-467]
--
N
P
Y
D
V
V
V
I
G
G
G
P
G
G
Y
V
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
--------
R
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
H
A
N
--
F
--
A
R
Y
G
L
-
M
G
G
E
G
-
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
D
G
------
K
Q
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
-
F
L
P-
F
--
D
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
K
N
-
E
K
M
K
F
M
T
S
T
K
V
V
G
G
--
T
N
--
N
G
D
----
S
V
S
L
E
V
E
G------
K
R
---
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
-
D
K
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
---
A
G
K
P
G
H
V
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
-------
83
PsiBlast_CBE
66.59
46%
5
- C1 -
-
2EQ6
2
?
B:
[5-463]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
--------
E
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
----
E
T
L
H
H
--
L
KV
A
E
G
F
G
-
L
K
-
A
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
---
G
G
------
E
R
Y
--
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
V
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
-
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
--
E
K
KK
D
G
L
----
H
V
R
L
E
P
A
--
E
--
G
G
E
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
---
A
G
K
D
S
A
F
D
Y
Q
-
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
N
----
18
PsiBlast_PDB
65.55
46%
3
- C1 -
-
2EQ6
2
?
A:
[5-463]
--
K
T
Y
D
L
I
V
I
G
T
G
P
G
G
Y
H
A
A
I
R
A
A
Q
L
G
L
K
V
L
A
V
E
A
-
G
--------
E
V
G
G
V
C
L
N
V
G
C
I
P
T
K
A
L
L
H
A
A
----
E
T
L
H
H
--
L
K
V
A
E
G
F
G
-
L
K
-
A
K
-
P
E
L
D
L
K
K
L
G
G
W
R
D
Q
V
V
K
K
L
T
G
G
V
G
T
L
L
K
G
N
G
V
E
L
L
R
G
F
A
R
L
V
G
P
K
E
V
E
V
---
G
G
------
E
R
Y
--
G
A
K
S
L
I
L
A
T
G
S
E
P
L
E
L
K
G
F
P
--
F
--
G
E
D
V
W
-
D
S
T
R
A
L
K
V
E
-
E
G
L
P
K
R
L
L
V
I
G
G
G
A
V
G
L
E
L
G
Q
V
Y
R
R
L
G
A
E
V
T
L
I
E
Y
M
P
E
I
L
P
Q
G
D
P
E
T
A
A
L
L
R
R
A
L
E
-
K
-
E
G
I
R
V
R
T
K
T
K
A
V
G
Y
--
E
K
K
K
D
G
L
----
H
V
R
L
E
P
A
--
E
--
G
G
E
G
---
E
E
V
V
V
D
K
V
L
V
A
V
G
R
K
P
R
T
E
G
L
G
L
E
K
A
G
V
K
V
D
E
R
G
F
I
R
V
N
A
R
M
E
T
S
V
P
G
V
Y
A
I
G
D
A
A
-
R
-
P
P
L
L
A
H
K
A
M
R
E
G
L
I
A
A
E
N
A
---
A
G
K
D
S
A
F
D
Y
Q
-
V
P
S
V
V
Y
T
S
P
E
W
A
G
V
G
L
T
E
E
E
A
K
R
A
G
Y
K
V
K
V
G
K
F
P
L
A
A
S
G
R
A
L
T
L
G
G
A
E
G
M
V
K
V
V
G
D
E
E
T
D
L
L
L
G
V
F
I
V
G
P
Q
A
G
E
L
I
A
E
A
A
L
A
L
E
M
G
A
T
L
T
D
L
A
L
T
V
H
P
H
P
T
L
S
E
S
L
M
E
A
A
E
A
F
H
K
Q
A
I
H
I
L
N
----
96
PsiBlast_CBE
65.09
38%
-24
- C1 -
-
1LVL
2
DLDH1_PSEPU
A:
[5-457]
---
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
-
Q
--------
A
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
Q
F
H
Q
A
S
R
F
--
T
E
P
S
P
L
G
I
-
S
V
-
A
S
-
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
Q
V
E
V
-----------
D
G
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
M
L
P
--
L
--
G
G
P
V
I
-
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
-
K
-
L
G
I
A
L
H
L
G
H
S
V
E
G
Y
--
E
---
N
G
C
-----
L
L
A
N
D
G
--
K
--
G
G
Q
L
---
R
L
E
A
-
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
G
A
A
-
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
-
G
-
E
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
---
A
G
K
A
R
R
F
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
-------
84
PsiBlast_CBE
64.94
42%
0
- C1 -
-
2QAE
2
DLDH_TRYCR
B:
[17-467]
------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-
R
-------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
H
A
N
--
F
--
A
R
Y
G
L
-
M
G
-
G
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
D
G
------
K
Q
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
-
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
--
T
N
--
N
G
D
----
S
V
S
L
E
V
E
G------
K
R
---
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
-
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
---
A
G
K
P
G
H
V
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
-------
85
PsiBlast_CBE
63.85
42%
0
- C1 -
-
2QAE
2
DLDH_TRYCR
A:
[17-467]
------------------
A
S
I
K
A
A
Q
L
G
M
K
T
A
C
V
E
K
-
R
-------
G
A
L
G
G
T
C
L
N
V
G
C
I
P
S
K
A
L
L
H
A
T
H
L
Y
H
D
A
H
A
N
--
F
--
A
R
Y
G
L
-
M
G
-
G
E
G
V
T
M
D
S
A
K
M
Q
Q
Q
K
E
R
A
V
K
G
L
T
G
G
V
E
Y
L
F
K
K
N
K
V
T
Y
Y
K
G
E
G
S
F
E
T
A
H
S
I
R
V
N
G
L
D
G
------
K
Q
E
M
L
E
T
K
K
T
I
I
A
T
G
S
E
P
T
E
L
P
F
L
P
--
F
--
D
E
K
V
V
L
S
S
T
G
A
L
A
L
P
-
R
-
V
P
K
T
M
V
V
I
G
G
G
V
I
G
L
E
L
G
S
V
W
A
R
L
G
A
E
V
T
V
V
E
F
A
P
R
C
A
P
T
L
D
E
D
V
T
N
A
L
V
G
A
L
A
-
K
N
E
K
M
K
F
M
T
S
T
K
V
V
G
G
--
T
N
--
N
G
D
----
S
V
S
L
E
V
E
G------
K
R
---
E
T
V
T
C
E
A
L
L
V
S
V
G
R
R
P
F
T
G
G
L
G
L
D
K
I
N
V
A
K
N
E
R
G
F
V
K
I
G
D
H
F
E
T
S
I
P
D
V
Y
A
I
G
D
V
V
D
K
-
G
P
M
L
A
H
K
A
E
D
E
G
V
A
C
A
E
I
L
---
A
G
K
P
G
H
V
N
Y
G
V
I
P
A
V
I
Y
T
M
P
E
V
A
S
V
G
K
S
E
D
E
L
K
K
E
G
V
A
Y
K
V
G
K
F
P
F
N
A
N
S
R
A
K
A
V
S
T
E
D
G
F
V
K
V
L
V
D
K
A
T
D
R
I
L
G
V
H
I
V
C
T
T
A
G
E
L
I
G
E
A
C
L
A
M
E
Y
G
A
S
S
E
D
V
G
R
T
C
H
A
H
P
T
M
S
E
A
L
K
E
A
C
M
A
L
F
A
K
T
I
N
-------
109
HHSearch
63.72
38%
-25
- C1 -
-
1LVL
2
DLDH1_PSEPU
A:
[2-458]
Q
T
I
Q
T
T
L
L
I
I
G
G
G
P
G
G
Y
V
A
A
I
R
A
G
Q
L
G
I
P
T
V
L
V
E
G
--------
Q
-
A
L
G
G
T
C
L
N
I
G
C
I
P
S
K
A
L
I
H
V
A
E
Q
F
H
Q
A
S
R
F
T
E
P
--
S
P
L
G
I
-
S
V
-
A
S
-
P
R
L
D
I
G
Q
S
V
A
W
K
D
G
I
V
D
R
L
T
T
G
V
A
A
L
L
K
K
H
G
V
K
V
V
H
G
W
A
K
V
L
D
G
K
Q
V
E
V
---
D
G
--------
Q
R
I
Q
C
E
H
L
L
L
A
T
G
S
S
S
V
E
L
P
-
M
L
--
P
--
L
G
G
P
V
I
S
S
T
E
A
L
A
P
K
-
A
-
L
P
Q
H
L
V
V
V
G
G
G
Y
I
G
L
E
L
G
I
A
Y
R
K
L
G
A
Q
V
S
V
V
E
A
R
E
R
I
L
P
T
Y
D
S
E
L
T
A
P
V
A
E
S
L
K
-
K
-
L
G
I
A
L
H
L
G
H
S
V
E
G
Y
--
E
N
--
G
------
C
L
L
A
N
-
D
--
G
--
K
G
G
Q
---
L
R
L
E
A
D
R
V
L
V
A
V
G
R
R
P
R
T
K
G
F
N
L
E
C
L
D
L
K
M
N
-
G
A
A
I
A
I
D
E
R
C
Q
T
S
M
H
N
V
W
A
I
G
D
V
A
-
G
-
E
P
M
L
A
H
R
A
M
A
Q
G
E
M
V
A
E
I
I
---
A
G
K
A
R
R
F
E
P
A
A
I
A
A
V
C
F
T
D
P
E
V
V
V
V
G
K
T
P
E
Q
A
S
Q
Q
G
L
D
C
I
V
A
Q
F
P
F
A
A
N
G
R
A
M
S
L
E
S
K
S
G
F
V
R
V
V
A
R
R
D
N
H
L
I
L
G
W
Q
A
V
G
V
A
V
S
E
L
S
T
A
F
A
Q
S
L
E
M
G
A
C
L
E
D
V
A
G
T
I
H
A
H
P
T
L
G
E
A
V
Q
E
A
A
L
R
A
L
G
H
A
L
H
I
------