@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSL4: (2017-12-09 )
MSNVDQRPIILTGDRPTGQLHLGHFVGSLRSRVGLQDSHHQHLLLADAQALTDNADNPDKVRRNILEVALDYLAVGIDPTKTTICVQSCLPALNELTMLYLNFVTVARLERNPTIKSEIQMRGFERDIPAGFLCYPVAQAADITAFKATVVPVGEDQIPMIEQTNEIVRRVNRQIGQDLLPECKALLSNMARLPGFDGKAKMSKSLGNTIVLNASDKDIKKAVNAMYTDPNHLRIEDPGQVEGNIVFTYLDAFDPNKEEVEELKAHYRRGGLGDGTVKKRLEGVLKELITPMRERREELAKDPDYIMDVLRQGTDKCRIITQQTLDEVKDGLGLFKF
Atome Classification :
(20 SA)
.........10........20........30.....-.-.--.40-........50...-.-....60........70........80........90........100.......110..---.....120.......130.......140.......150.......160.......170.......-180.....-.-.-190.....-...200......---.210.......220.......230---....-....240.......250.......260.......270.......280.......290.......300.......310.......320.......330.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSNVDQR
P
I
I
L
TGDRPTG
Q
L
H
L
G
H
F
V
G
S
L
R
S
RVGLQ-D-S--HH
Q
-
H
L
L
L
A
D
A
Q
A
LTDN-A-D
N
P
D
K
V
R
R
N
I
L
E
V
A
L
D
Y
L
AVGIDPT
K
T
T
I
C
V
Q
S
C
L
P
A
L
N
E
L
T
M
L
Y
L
N
F
V
T
V
A
R
LERNPT---
I
K
S
E
I
Q
MRGFERDIPA
G
F
L
CYPVAQAAD
I
T
A
F
K
A
T
V
V
PVGEDQIP
M
I
E
Q
T
N
E
I
V
R
R
V
N
R
Q
I
G
Q
D
L
-
L
P
E
C
K
A
L
L
-
S
-
N
-
M
A
-RLPGF-D
G
K
A
K
M
S
K
SLG
N
---
T
I
V
L
NAS
D
K
D
I
K
K
A
V
N
A
MYTDP
N
----
H
L
R
I-EDPGQVEG
N
I
V
F
T
Y
LDAFDP
N
K
E
E
V
E
E
L
K
A
H
Y
RRGGLG
D
G
T
V
K
K
R
L
E
G
V
L
K
E
L
I
T
P
M
R
E
R
R
E
E
LAKD
P
D
Y
I
M
D
V
L
RQGTDK
C
R
I
I
T
Q
Q
T
L
D
E
V
K
D
G
LGLFKF
24
HHSearch
98.26
57%
-106
- C4 -
-
2A4M
-
SYW2_DEIRA
A:
[22-350]
------
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
A
-
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
G
-
1
PsiBlast_PDB
97.72
56%
-106
- C4 -
-
2A4M
-
SYW2_DEIRA
A:
[22-349]
------
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
-
A
L
Y
A
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
--
21
PsiBlast_CBE
97.52
56%
-106
- C4 -
-
2A4M
1
SYW2_DEIRA
C:
[22-349]
------
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
-
A
L
Y
A
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
--
23
HHSearch
97.45
56%
-104
- C4 -
-
1YI8
-
SYW2_DEIRA
B:
[21-350]
-----
A
R
P
R
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
A
L
Y
A
-
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
G
-
2
PsiBlast_PDB
96.55
56%
-107
- C4 -
-
1YI8
-
SYW2_DEIRA
B:
[25-349]
---------
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
-
A
L
Y
A
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
--
22
PsiBlast_CBE
96.35
56%
-110
- C4 -
-
1YI8
1
SYW2_DEIRA
C:
[25-349]
---------
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
-
A
L
Y
A
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
--
3
PsiBlast_PDB
96.29
56%
-108
- C4 -
-
1YIA
1
SYW2_DEIRA
B:
[25-349]
---------
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
-
A
L
Y
A
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
--
4
PsiBlast_PDB
96.27
56%
-105
- C4 -
-
1YID
1
SYW2_DEIRA
B:
[25-349]
---------
V
L
T
G
D
R
P
T
G
A
L
H
L
G
H
L
A
G
S
L
Q
N
R
V
R
L
Q
-
D
-
E
--
A
E
L
-
F
V
L
L
A
D
V
Q
A
L
T
D
H
-
F
-
D
R
P
E
Q
V
R
E
N
V
L
A
V
A
L
D
Y
L
A
A
G
L
D
P
Q
K
T
T
C
V
V
Q
S
A
V
P
E
L
A
E
L
T
V
Y
F
L
N
L
V
T
V
S
H
L
R
Q
N
P
T
---
V
K
A
E
I
A
Q
K
G
Y
G
E
R
V
P
A
G
F
F
V
Y
P
V
S
Q
A
A
D
I
A
A
F
G
A
T
L
V
P
V
G
D
D
Q
L
P
M
L
E
Q
T
R
E
I
V
R
R
F
N
-
A
L
Y
A
P
V
-
L
A
E
P
Q
A
Q
L
-
S
-
R
-
V
P
-
R
L
P
G
L
-
D
G
Q
A
K
M
S
K
S
L
G
N
---
A
I
A
L
G
D
S
A
D
E
V
A
R
K
V
M
G
M
Y
T
D
P
G
----
H
L
R
A
-
S
D
P
G
R
V
E
G
N
P
V
F
T
F
L
D
A
F
D
P
D
P
A
R
V
Q
A
L
K
D
Q
Y
R
A
G
G
L
G
D
V
K
V
K
K
H
L
I
D
V
L
N
G
V
L
A
P
I
R
T
R
R
A
E
Y
E
R
D
P
D
A
V
L
R
F
V
T
E
G
T
A
R
G
R
E
V
A
A
Q
T
L
G
Q
V
R
R
A
M
R
L
F
--
26
HHSearch
81.81
41%
-11
- C4 -
-
2G36
2
SYW_THEMA
A:
[12-339]
------
H
M
R
I
L
S
G
M
R
P
T
G
K
L
H
I
G
H
L
V
G
A
L
E
N
W
V
K
L
Q
-
E
E
G
--
N
E
C
-
F
Y
F
V
A
D
W
H
A
L
T
T
H
-
Y
-
D
D
V
S
K
L
K
E
Y
T
R
D
L
V
R
G
F
L
A
C
G
I
D
P
E
K
S
V
I
F
V
Q
S
G
V
K
E
H
A
E
L
A
L
L
F
S
M
I
V
S
V
S
R
L
E
R
V
P
T
---
Y
K
E
I
-------
D
L
S
T
A
G
F
L
I
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
E
G
V
P
V
G
E
D
Q
V
Y
H
I
E
L
T
R
E
I
A
R
R
F
N
Y
L
Y
D
-
E
V
-
F
P
E
P
E
A
I
L
-
S
-
R
-
V
P
-
K
L
P
G
T
-
D
G
-
R
K
M
S
K
S
Y
G
N
---
I
I
N
L
E
I
S
E
K
E
L
E
Q
T
I
L
R
M
M
T
D
P
A
----
R
V
R
R
-
S
D
P
G
N
P
E
N
C
P
V
W
K
Y
H
Q
A
F
D
I
S
E
E
E
S
K
W
V
W
E
G
C
T
T
A
S
I
G
C
V
D
C
K
K
L
L
L
K
N
M
K
R
K
L
A
P
I
W
E
N
F
R
K
I
D
E
D
P
H
Y
V
D
D
V
I
M
E
G
T
K
K
A
R
E
V
A
A
K
T
M
E
E
V
R
R
A
M
N
L
M
--
6
PsiBlast_PDB
81.26
41%
-18
- C4 -
-
2G36
2
SYW_THEMA
A:
[15-338]
---------
I
L
S
G
M
R
P
T
G
K
L
H
I
G
H
L
V
G
A
L
E
N
W
V
K
L
Q
-
E
-
E
--
G
N
E
C
F
Y
F
V
A
D
W
H
A
L
T
T
H
-
Y
-
D
D
V
S
K
L
K
E
Y
T
R
D
L
V
R
G
F
L
A
C
G
I
D
P
E
K
S
V
I
F
V
Q
S
G
V
K
E
H
A
E
L
A
L
L
F
S
M
I
V
S
V
S
R
L
E
R
V
P
T
YKE
I
-------
D
L
S
---
T
A
G
F
L
I
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
E
G
V
P
V
G
E
D
Q
V
Y
H
I
E
L
T
R
E
I
A
R
R
F
N
-
Y
L
Y
D
E
V
-
F
P
E
P
E
A
I
L
-
S
-
R
-
V
P
-
K
L
P
G
T
-
D
G
R
-
K
M
S
K
S
Y
G
N
---
I
I
N
L
E
I
S
E
K
E
L
E
Q
T
I
L
R
M
M
T
D
P
A
----
R
V
R
R
-
S
D
P
G
N
P
E
N
C
P
V
W
K
Y
H
Q
A
F
D
I
S
E
E
E
S
K
W
V
W
E
G
C
T
T
A
S
I
G
C
V
D
C
K
K
L
L
L
K
N
M
K
R
K
L
A
P
I
W
E
N
F
R
K
I
D
E
D
P
H
Y
V
D
D
V
I
M
E
G
T
K
K
A
R
E
V
A
A
K
T
M
E
E
V
R
R
A
M
N
L
---
25
HHSearch
79.42
41%
-26
- C4 -
-
2EL7
-
?
A:
[2-329]
-------
K
R
V
L
S
G
I
Q
P
S
G
E
I
H
I
G
N
Y
L
G
A
I
K
Q
W
V
A
I
G
E
K
L
G
--
R
D
A
-
F
F
C
I
V
D
Y
H
A
L
T
N
P
-
L
A
Y
D
P
S
T
L
A
Q
R
T
F
E
A
A
L
V
N
I
A
A
G
L
D
P
E
K
V
T
L
F
V
Q
S
H
V
P
E
H
T
E
L
S
W
V
F
T
T
L
T
P
L
G
D
L
T
R
M
T
Q
---
F
K
D
K
A
S
---
K
Q
E
T
V
W
S
G
L
L
M
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
D
T
V
P
V
G
E
D
Q
V
Q
H
I
E
L
T
R
E
I
A
R
R
F
N
H
L
F
G
-
E
T
-
F
P
E
P
Q
A
L
L
-
N
-
P
E
A
P
-
R
V
P
G
I
-
D
G
K
A
K
M
S
K
S
L
G
N
---
T
I
G
L
L
E
P
E
E
S
I
W
Q
K
I
Q
H
L
P
D
D
P
------------------
T
I
L
F
T
Y
L
S
Y
F
A
P
K
-
D
L
V
E
A
L
K
E
E
Y
R
K
A
G
V
G
T
Y
V
V
K
R
I
L
F
D
H
L
M
E
A
L
R
P
I
R
E
R
A
E
A
L
K
K
D
P
D
Y
V
M
D
A
L
L
E
G
A
K
R
A
R
A
V
A
Q
A
T
M
E
E
V
R
E
K
V
G
L
L
L
-
5
PsiBlast_PDB
79.37
40%
-25
- C4 -
-
2EL7
-
?
A:
[4-328]
---------
V
L
S
G
I
Q
P
S
G
E
I
H
I
G
N
Y
L
G
A
I
K
Q
W
V
A
I
G
-
E
-
K
LG
R
D
A
-
F
F
C
I
V
D
Y
H
A
L
T
N
P
L
A
-
Y
D
P
S
T
L
A
Q
R
T
F
E
A
A
L
V
N
I
A
A
G
L
D
P
E
K
V
T
L
F
V
Q
S
H
V
P
E
H
T
E
L
S
W
V
F
T
T
L
T
P
L
G
D
L
T
R
M
T
Q
---
F
K
D
K
A
S
K
---
Q
E
T
V
W
S
G
L
L
M
Y
P
V
L
Q
A
A
D
I
L
I
Y
K
A
D
T
V
P
V
G
E
D
Q
V
Q
H
I
E
L
T
R
E
I
A
R
R
F
N
H
L
F
G
E
T
F
--
P
E
P
Q
A
L
L
-
N
-
P
-
E
A
P
R
V
P
G
I
-
D
G
K
A
K
M
S
K
S
L
G
N
---
T
I
G
L
L
E
P
E
E
S
I
W
Q
K
I
Q
H
L
P
D
D
P
------------------
T
I
L
F
T
Y
L
S
Y
F
A
P
-
K
D
L
V
E
A
L
K
E
E
Y
R
K
A
G
V
G
T
Y
V
V
K
R
I
L
F
D
H
L
M
E
A
L
R
P
I
R
E
R
A
E
A
L
K
K
D
P
D
Y
V
M
D
A
L
L
E
G
A
K
R
A
R
A
V
A
Q
A
T
M
E
E
V
R
E
K
V
G
L
L
--
36
HHSearch
78.39
32%
-59
- C4 -
-
3TZL
2
SYW_CAMJE
B:
[3-322]
------
A
M
R
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
-
E
-
K
--
S
Q
M
-
F
M
F
I
A
N
Y
H
A
M
T
S
S
-
Q
--
D
G
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
---
Y
K
D
K
V
A
K
---
G
L
S
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
E
-
I
-
F
T
L
P
E
A
R
V
-
N
E
E
-
V
A
-
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
Y
Q
N
---
T
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
T
----
A
--
L
-
E
D
P
K
D
H
E
N
C
N
I
F
K
I
A
K
L
F
L
D
E
-
S
G
Q
K
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
---
7
PsiBlast_PDB
77.20
32%
-52
- C4 -
-
3M5W
1
SYW_CAMJE
A:
[6-322]
---------
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
-
E
-
K
--
S
Q
M
-
F
M
F
I
A
N
Y
H
A
M
T
S
S
-
Q
-
D
G
-
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
---
Y
K
D
----------
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
E
I
F
T
L
P
E
A
R
-
V
-------
A
-
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
Y
Q
N
---
T
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
T
----
A
L
---
E
D
P
K
D
H
E
N
C
N
I
F
K
I
A
K
L
F
-
L
D
E
S
G
Q
K
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
---
8
PsiBlast_PDB
76.81
32%
-47
- C4 -
-
3TZL
2
SYW_CAMJE
A:
[6-322]
---------
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
-
E
-
K
--
S
Q
M
-
F
M
F
I
A
N
Y
H
A
M
T
S
S
-
Q
-
D
G
-
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
---
Y
K
D
K
V
-
A
K
G
L
--
S
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
E
I
F
T
L
P
E
A
R
-
V
N
-
E
-
E
-
V
A
-
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
Y
Q
N
---
T
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
T
----
A
L
---
E
D
P
K
D
H
E
N
C
N
I
F
K
I
A
K
L
F
-
L
D
E
S
G
Q
K
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
---
37
HHSearch
76.77
32%
-55
- C4 -
-
3TZL
2
SYW_CAMJE
A:
[4-322]
-------
M
R
V
L
T
G
L
Q
P
S
G
D
L
H
I
G
N
Y
F
G
A
I
K
Q
M
V
D
A
Q
-
E
-
K
--
S
Q
M
-
F
M
F
I
A
N
Y
H
A
M
T
S
S
-
Q
--
D
G
E
K
L
K
Q
N
S
L
K
A
A
A
A
F
L
S
L
G
I
D
P
Q
K
S
V
F
W
L
Q
S
D
V
K
E
V
M
E
L
Y
W
I
L
S
Q
F
T
P
M
G
L
L
E
R
A
H
S
---
Y
K
D
K
V
A
K
---
G
L
S
A
S
H
G
L
F
S
Y
P
V
L
M
A
A
D
I
L
L
F
D
T
R
I
V
P
V
G
K
D
Q
I
Q
H
V
E
I
A
R
D
I
A
L
K
V
N
N
E
W
G
E
-
I
-
F
T
L
P
E
A
R
V
-
N
E
E
-
V
A
-
V
V
V
G
T
-
D
G
-
A
K
M
S
K
S
Y
Q
N
---
T
I
D
I
F
S
S
E
K
T
L
K
K
Q
I
S
S
I
V
T
D
S
T
----
A
--
L
-
E
D
P
K
D
H
E
N
C
N
I
F
K
I
A
K
L
F
L
D
E
-
S
G
Q
K
E
L
Q
I
R
Y
E
K
G
G
E
G
Y
G
H
F
K
I
Y
L
N
E
L
V
N
A
Y
F
K
E
A
R
E
K
Y
N
E
L
L
E
K
P
S
H
L
K
E
I
L
D
F
G
A
T
K
A
R
K
I
A
Q
E
K
M
Q
K
I
Y
E
K
I
G
L
---
15
PsiBlast_PDB
76.48
30%
-44
- C4 -
-
1MB2
1
SYW_GEOSE
A:
[4-324]
---------
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
-
H
-
E
--
Y
N
C
-
Y
F
C
I
V
D
Q
H
A
I
T
V
W
-
Q
-
D
-
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
M
T
Q
---
F
K
E
K
---
S
A
G
K
E
A
V
S
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
E
L
F
T
I
P
E
A
R
I
P
K
-
V
-
G
-
A
R
-
I
M
S
L
V
-
D
P
T
K
K
M
S
K
S
D
P
N
PKA
Y
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
GTIR
Y
D
K
E
-
A
K
P
G
I
S
N
L
L
N
I
Y
S
T
L
S
G
-----
Q
S
I
E
E
L
E
R
Q
Y
E
--
G
K
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
E
E
-
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
---
13
PsiBlast_PDB
75.75
30%
-42
- C4 -
-
1MAU
6
SYW_GEOSE
A:
[4-324]
---------
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
-
H
-
E
--
Y
N
C
-
Y
F
C
I
V
D
Q
H
A
I
T
V
W
-
Q
-
D
-
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
M
T
Q
---
F
K
E
K
---
S
A
G
K
E
A
V
S
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
E
L
F
T
I
P
E
A
R
I
P
K
-
V
-
G
-
A
R
-
I
M
S
L
V
-
D
P
T
K
K
M
S
K
S
D
P
N
PKA
Y
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
GTIR
Y
D
K
E
-
A
K
P
G
I
S
N
L
L
N
I
Y
S
T
L
S
G
-----
Q
S
I
E
E
L
E
R
Q
Y
E
--
G
K
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
E
E
-
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
---
16
PsiBlast_PDB
75.49
30%
-37
- C4 -
-
2OV4
4
SYW_GEOSE
A:
[4-324]
---------
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
-
H
-
E
--
Y
N
C
-
Y
F
C
I
V
D
Q
H
A
I
T
V
W
-
Q
-
D
-
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
M
T
Q
---
F
K
E
K
---
S
A
G
K
E
A
V
S
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
E
L
F
T
I
P
E
A
R
I
P
K
-
V
-
G
-
A
R
-
I
M
S
L
V
-
D
P
T
K
K
M
S
K
S
D
P
N
PKA
Y
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
GTIR
Y
D
K
E
-
A
K
P
G
I
S
N
L
L
N
I
Y
S
T
L
S
G
-----
Q
S
I
E
E
L
E
R
Q
Y
E
--
G
K
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
E
E
-
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
---
35
HHSearch
75.40
30%
-12
* C4 *
-
1I6L
7
SYW_GEOSE
A:
[1-326]
------
M
K
T
I
F
S
G
I
Q
P
S
G
V
I
T
I
G
N
Y
I
G
A
L
R
Q
F
V
E
L
Q
-
H
-
E
--
Y
N
C
-
Y
F
C
I
V
D
Q
H
A
I
T
V
W
---
Q
D
P
H
E
L
R
Q
N
I
R
R
L
A
A
L
Y
L
A
V
G
I
D
P
T
Q
A
T
L
F
I
Q
S
E
V
P
A
H
A
Q
A
A
W
M
L
Q
C
I
V
Y
I
G
E
L
E
R
M
T
Q
---
F
K
E
K
S
A
G
---
K
E
A
V
S
A
G
L
L
T
Y
P
P
L
M
A
A
D
I
L
L
Y
N
T
D
I
V
P
V
G
E
D
Q
K
Q
H
I
E
L
T
R
D
L
A
E
R
F
N
K
R
Y
G
E
-
L
-
F
T
I
P
E
A
R
I
P
K
-
V
-
G
A
-
R
I
M
S
L
V
D
P
T
K
K
M
S
K
S
D
P
N
PKA
Y
I
T
L
L
D
D
A
K
T
I
E
K
K
I
K
S
A
V
T
D
S
E
----
G
T
I
R
Y
D
K
E
A
K
P
G
I
S
N
L
L
N
I
Y
S
T
L
S
G
--
Q
S
I
E
E
L
E
R
Q
Y
E
G
K
--
G
Y
G
V
F
K
A
D
L
A
Q
V
V
I
E
T
L
R
P
I
Q
E
R
Y
H
H
W
M
E
S
-
E
E
L
D
R
V
L
D
E
G
A
E
K
A
N
R
V
A
S
E
M
V
R
K
M
E
Q
A
M
G
L
G
R
-