@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSM5: (2017-12-09 )
MSDYFKNAVLWLIILGVLILIFSNISDRNKPTAMKYSDFIAAVNAGQIKQVTIDGLNISGEKTNGSQFETVRPQVEDTELMPSLNKQNVVVEGTAPQRQGILMQLLIASFPVLLIILLFMFFMRNMGGGAGGKNGPMSFGKSKAKMLSEDQIKVTFADVAGCDEAKQEVVEIVDFLKDPAKFKRLGATIPRGVLMVGPPGTGKTLLAKAIAGEAKVPFFSISGSDFVEMFVGVGASRVRDMFEQAKRHAPCIIFIDEIDAVGRHRGSGTGGGHDEREQTLNQMLVEMDGFEGNEGVIVIAATNRVDVLDKALLRPGRFDRQVMVGLPDIRGREQILNVHLKKLPSVTGIDVKVLSRGTPGFSGAQLANLVNEAALFAARRNKNTVDMHDFEDAKDKIYMGPERKSMVLREEERRATAYHEAGHAIVAEILPGTDPVHKVTIMPRGWALGVTWQLPEQDQISHYKDKMLNEIAILFGGRIAEEVFIQQQSTGASNDFERATKMARAMVTKYGMSDKMGVMVYEDENQNGFFGNVGSRTISEATQQQVDQEVRRILDEQYKVARDILENNKDIALAMVKALMEWETIDRDQIRDIMEGREPQPPKVYIAENPVSAFEPPKDGPSTPPPLPAMN
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170...-....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.-.......300.......310.......320.......330.......340-....-....350.......360.......370.......380----------.......390.......400.......410.......420.......430.......440....-...450.......460.-......470.......480......--.490.......500.......510.......520.......530.....-..540.......550.......560.......570.......580.......590.......600.......610.......620.......630
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
D
Y
F
K
N
A
V
L
W
L
I
I
L
G
V
L
I
L
I
FSNISDRNKPTA
M
K
Y
S
D
F
I
A
AVNAG
Q
I
K
Q
V
T
ID
G
L
NISGEKTNGSQFETVRPQVE
D
T
E
LMPSLNKQ
N
V
V
V
EGTAP
Q
R
Q
G
I
L
M
Q
L
L
I
A
S
F
P
V
L
L
I
I
L
L
F
M
F
F
M
R
NMGGGAGGKNG
P
M
SF
G
K
S
K
A
K
MLSED
Q
I
K
V
T
F
ADVAG
C
D
E
A
K
Q
E
V
V
E
I
V
D
F
-LK
D
P
A
K
F
K
R
L
GATIPR
G
V
L
M
VGPPGT
G
K
T
L
L
A
K
A
IAGEAKV
P
F
F
SIS
G
S
D
F
V
E
M
F
V
GV
G
A
S
R
V
R
D
M
F
E
Q
A
KRHA
P
C
I
I
F
I
DEI
D
A
V
GRHRGSGTGGG
H
D
E
R
E
Q
T
L
N
Q
M
L
V
EMDGF-EG-NE
G
V
I
V
I
A
ATN
R
V
D
V
L
D
K
A
LLRPGRFD
R
Q
V
M
VGLPDIR
G
R
E
Q
I
L
N
V
H
L
K
--KLPS-VTG
I
D
V
K
V
L
SRGTPGF
S
G
A
Q
L
A
N
L
V
N
E
A
A
L
F
A
ARRNK----------NTVDMHDFEDAKD
K
I
Y
MGP
E
R
K
S
M
V
L
R
E
E
E
R
R
A
T
A
Y
H
EA
G
H
A
I
V
A
E
ILPGTDP
V
H
K
V
T
I
MPR
G
W
-
A
L
G
V
T
WQLP
E
Q
D
Q
I
S
H
Y
-
K
D
K
M
L
N
E
I
A
I
L
FGG
R
I
A
E
E
V
F
I
Q
QQ--STGAS
N
D
F
E
R
A
T
K
M
A
R
A
M
V
T
KYGMSDK
M
G
V
M
V
Y
EDENQNGFFGNVGS
R
T
-
I
S
E
A
T
Q
Q
Q
V
D
Q
E
V
R
R
I
L
D
E
Q
Y
K
V
A
R
D
I
L
ENNK
D
I
A
L
A
M
V
K
A
L
M
E
WETI
D
R
D
Q
I
R
D
I
M
EGREPQP
P
K
V
Y
IAENPVSAFEPPKDGPSTPPPLPAMN
153
Fugue
90.03
52%
-111
- C3 -
-
2CE7
-
FTSH_THEMA
A:
[5-457]
-------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
S
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
-
A
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
----------
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
--------
I
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
-----------------
V
S
-
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
L
-----------
R
N
-
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
------------------------------------
121
HHSearch
87.33
53%
-103
- C3 -
-
2DHR
1
FTSH_THET8
E:
[18-475]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
-
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
-
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
A
P
E
----------------------------
4
PsiBlast_PDB
86.57
54%
-82
- C3 -
-
4WW0
1
FTSH_AQUAE
A:
[4-459]
----------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
-
A
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
----------
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-----------------
H
I
Y
D
-
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
-
R
-------------D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
------------------------------------
33
PsiBlast_CBE
85.93
52%
-68
- C3 -
-
4EIW
1
FTSH_THET8
E:
[27-477]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
3
PsiBlast_PDB
85.73
52%
-68
- C3 -
-
4EIW
1
FTSH_THET8
A:
[27-477]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
35
PsiBlast_CBE
85.37
52%
-66
- C3 -
-
4EIW
1
FTSH_THET8
C:
[27-477]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
37
PsiBlast_CBE
85.12
54%
-75
- C3 -
-
4Z8X
1
FTSH_AQUAE
C:
[5-459]
-----------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
-
A
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
----------
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
-
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
-
R
-------------D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
------------------------------------
120
HHSearch
85.09
53%
-67
- C3 -
-
3KDS
1
FTSH_THEMA
E:
[11-458]
-------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
-
A
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
----------
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
-
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
----------
R
L
R
N
-
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
-----------------------------------
1
PsiBlast_PDB
84.74
53%
-70
- C3 -
-
3KDS
1
FTSH_THEMA
E:
[12-456]
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
-
A
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
----------
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
-
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
----------
R
L
R
N
-
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
-------------------------------------
5
PsiBlast_PDB
84.44
54%
-74
- C3 -
-
4Z8X
1
FTSH_AQUAE
A:
[5-459]
-----------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
-
A
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
----------
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
-
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
-
R
-------------D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
------------------------------------
122
HHSearch
84.41
53%
-71
- C3 -
-
2CE7
-
FTSH_THEMA
C:
[9-461]
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
--
N
K
P
L
-
A
E
D
V
N
L
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
----------
D
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
-
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
-------------
R
N
-
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
E
F
E
--------------------------------
28
PsiBlast_CBE
84.19
52%
-71
- C3 -
-
2DHR
1
FTSH_THET8
E:
[18-468]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
2
PsiBlast_PDB
84.11
52%
-69
- C3 -
-
2DHR
1
FTSH_THET8
A:
[18-468]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
30
PsiBlast_CBE
84.10
52%
-71
- C3 -
-
2DHR
1
FTSH_THET8
C:
[18-468]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
39
PsiBlast_CBE
83.92
54%
-81
- C3 -
-
4WW0
2
FTSH_AQUAE
C:
[9-459]
---------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
----
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
-
A
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
----------
E
E
I
T
M
E
E
I
E
E
A
L
D
R
---------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
---------------
D
K
H
I
Y
D
-
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
-------------
A
V
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
------------------------------------
40
PsiBlast_CBE
82.65
54%
-77
- C3 -
-
4WW0
1
FTSH_AQUAE
B:
[3-459]
---------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
K
V
Y
I
E
--
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
D
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
--
N
K
K
L
-
A
K
D
V
D
L
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
----------
E
E
I
T
M
E
E
I
E
E
A
L
D
R
I
--------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
R
G
M
-
A
L
--------
E
D
K
H
I
Y
D
-
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
---------------D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
------------------------------------
31
PsiBlast_CBE
80.67
52%
-62
- C3 -
-
2DHR
1
FTSH_THET8
B:
[22-468]
--------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
27
PsiBlast_CBE
80.56
52%
-60
- C3 -
-
2DHR
1
FTSH_THET8
F:
[18-468]
----------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
29
PsiBlast_CBE
80.46
52%
-61
- C3 -
-
2DHR
1
FTSH_THET8
D:
[23-468]
---------------------------------------------------------------------------------------------------------------------------------------------------
T
E
A
P
-
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
R
-
A
L
G
--
F
M
M
P
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
-
V
R
E
D
T
Y
L
G
G
Y
D
V
R
Q
-
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
-----------------------------------
6
PsiBlast_PDB
77.75
80%
-119
- C3 -
-
1LV7
-
FTSH_ECOLI
A:
[1-256]
-------------------------------------------------------------------------------------------------------------------------------------------------
M
L
T
E
D
Q
I
K
T
T
F
A
D
V
A
G
C
D
E
A
K
E
E
V
A
E
L
V
E
Y
-
L
R
E
P
S
R
F
-----
K
I
P
K
G
V
L
M
V
G
P
P
G
T
G
K
T
L
L
A
K
A
I
A
G
E
A
K
V
P
F
F
T
I
S
G
S
D
F
V
E
M
F
V
G
V
G
A
S
R
V
R
D
M
F
E
Q
A
K
K
A
A
P
C
I
I
F
I
D
E
I
D
A
V
G
R
Q
R
G
A
G
L
G
G
G
H
D
E
R
E
Q
T
L
N
Q
M
L
V
E
M
D
G
F
-
E
G
-
N
E
G
I
I
V
I
A
A
T
N
R
P
D
V
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
V
V
V
G
L
P
D
V
R
G
R
E
Q
I
L
K
V
H
M
R
--
R
V
P
L
-
A
P
D
I
D
A
A
I
I
A
R
G
T
P
G
F
S
G
A
D
L
A
N
L
V
N
E
A
A
L
F
A
A
R
G
N
K
----------
R
V
V
S
M
V
E
F
E
K
A
K
D
K
I
M
M
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
72.19
66%
-121
- C3 -
-
1IY1
1
FTSH_THET8
A:
[12-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.84
66%
-123
- C3 -
-
1IY0
1
FTSH_THET8
A:
[12-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
-------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
-
E
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
--
G
K
P
L
-
A
E
D
V
D
L
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
----------
R
K
I
T
M
K
D
L
E
E
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.61
52%
-113
- C3 -
-
2QZ4
1
A:
[3-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
-
G
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
Q
-
S
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
------------------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
60.57
58%
-65
- C3 -
-
2R65
1
FTSH_HELPY
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
-
A
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
----------
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
59.37
58%
-55
- C3 -
-
2R65
1
FTSH_HELPY
E:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
-
A
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
----------
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
59.33
58%
-62
- C3 -
-
2R65
1
FTSH_HELPY
D:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
-
A
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
----------
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
59.11
58%
-58
- C3 -
-
2R65
1
FTSH_HELPY
B:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
-
A
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
----------
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
57.99
58%
-48
- C3 -
-
2R65
1
FTSH_HELPY
C:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
--
G
V
K
L
-
A
N
D
V
N
L
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
----------
K
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
53.80
47%
14
- C3 -
-
5EQT
1
PAN_PYRHO
A:
[2-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
Y
N
D
I
G
G
L
K
K
Q
L
Q
E
L
R
E
A
I
E
L
P
L
K
H
P
E
L
F
E
E
V
G
I
D
P
P
K
G
V
L
L
Y
G
P
P
G
C
G
K
T
L
M
A
K
A
L
A
H
E
V
N
A
T
F
I
R
V
V
G
S
E
L
V
R
K
Y
I
G
E
G
A
R
L
V
H
E
L
F
E
L
A
K
E
K
A
P
T
I
I
F
I
D
E
I
D
A
I
G
A
K
--------
E
R
E
V
N
R
T
L
M
Q
L
L
A
E
M
D
G
F
-
D
P
-
R
G
N
V
K
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
L
I
E
V
P
L
P
D
F
E
G
R
L
E
I
L
K
V
H
T
R
--
R
M
-
K
-
L
K
G
V
D
L
R
A
I
A
E
M
T
E
G
A
S
G
A
D
L
K
A
I
A
T
E
A
G
M
F
A
I
R
E
R
R
----------
T
Y
V
T
Q
E
D
F
L
K
A
V
D
K
V
-
L
G
N
E
R
K
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.42
44%
-0
- C3 -
-
3H4M
1
PAN_METJA
A:
[5-258]
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
-
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
-
A
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
----------
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
52.94
44%
-1
- C3 -
-
3H4M
1
PAN_METJA
B:
[5-258]
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
-
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
-
A
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
----------
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
HHSearch
50.34
34%
-23
- C3 -
-
3D8B
2
FIGL1_HUMAN
A:
[78-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
P
V
N
W
E
D
I
A
G
V
E
F
A
K
A
T
I
K
E
I
V
V
W
P
M
L
R
P
D
I
F
T
G
L
R
-
G
P
P
K
G
I
L
L
F
G
P
P
G
T
G
K
T
L
I
G
K
C
I
A
S
Q
S
G
A
T
F
F
S
I
S
A
S
S
L
T
S
K
W
V
G
E
G
E
K
M
V
R
A
L
F
A
V
A
R
C
Q
Q
P
A
V
I
F
I
D
E
I
D
S
L
L
S
Q
---------
E
S
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
----S
E
D
R
I
L
V
V
G
A
T
N
R
P
Q
E
I
D
E
A
A
R
R
--
R
L
V
K
R
L
Y
I
P
L
P
E
A
S
A
R
K
Q
I
V
I
N
L
M
S
--
K
E
Q
C
C
L
S
E
E
E
I
E
Q
I
V
Q
Q
S
D
A
F
S
G
A
D
M
T
Q
L
C
R
E
A
S
L
G
P
I
R
S
L
Q
TV--------
R
P
I
A
Y
I
D
F
E
N
A
F
R
T
V
R
P
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
49.99
44%
10
- C3 -
-
3H4M
1
PAN_METJA
C:
[5-258]
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
-
D
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
--
K
M
N
L
-
A
E
D
V
N
L
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
----------
D
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
HHSearch
49.37
34%
-14
- C3 -
-
3D8B
2
B:
[78-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
P
V
N
W
E
D
I
A
G
V
E
F
A
K
A
T
I
K
E
I
V
V
W
P
M
L
R
P
D
I
F
T
G
L
R
-
G
P
P
K
G
I
L
L
F
G
P
P
G
T
G
K
T
L
I
G
K
C
I
A
S
Q
S
G
A
T
F
F
S
I
S
A
S
S
L
T
-----
E
G
E
K
M
V
R
A
L
F
A
V
A
R
C
Q
Q
P
A
V
I
F
I
D
E
I
D
S
L
L
S
------------
S
R
R
I
K
T
E
F
L
V
Q
L
D
G
A
----
E
D
R
I
L
V
V
G
A
T
N
R
P
Q
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