@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSM9: (2017-12-09 )
MSEKISRRELIQKSLLGFGALSIPVAFTGCNDGSDDESPEIQADFLHGVASGDPLQDKVILWTRVTPTVSGVRLKVVWEISTDNQFKQNLKTGMVETSKTDDFTVKVDAAGLQADTVYYYRFKFGNKVSPVGQTKTLPTSTNKVSFAVCSCSNYPAGYFYVYREMAKQNVDVIIHLGDYIYEYGADGYATEDAIKLGRNLPADNNKEIIKLNDYRKRYALYRQDKDLKAAHQRHPFIVIWDDHELANDAWREGAENHQSNEGVFSDRKLAALQAYFEWMPIRPVSSTDHLNIYRQFNFGSLVQLTMLDTRIIARDKQLAYADYMTTTGLDIAKFQADLTNPVRTLMGYTQRDWLVDKLKQSTATWNVVGQQVLMSKMWIPAELLASLGQITSGGTSPDALAKMNAQITELVALKLRLQQNDPTLTAQEKARIMTVAPYNLDAWDGYYAEREFVYDKLAEFNKKIIVLAGDTHNAWASYLYSQKGKYVGVELATSSVSSPGLEKYLSIPLAQLQQFEFAFTTLIDELVYCNLNQRGYLLVTLDQVQVHSEWRFVDSIKNTEYQIDSSRQNDIVLDLNLMPLKQGQKTA
Atome Classification :
(20 SA)
------------.........10---.........20........30..--...----...40...-...--..50........60......------..70-----.--....-....80-........90----.....----...100.......110.........120...-----....130......---.---140-.........150..--------------...-------------.-------.160----..----.-------..--..170.......180.......190.....-------..200..----.....210.......220.......230.......240......-.250.......260....-----...270.......280....--..--.---290.....-.------.300.......310.......320.----......-330.......-340....-...350.------......360-.---.--.--......370......-.380.......390.......400.....--..410.......420.......430.........440.......450.......460.-.......470.......480--...----..----....490.......500.......510.-....---------..520.-......---530..-------....-----------.540.------......550.......560.......570......--------.580.....-------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------MSE
K
I
S
R
R
E
L
----
I
Q
K
S
L
LGFGALS
I
P
V
A
F
TGCNDG--SDD----ESP
E
I
Q
A
D
-
F
L
H--GVASGDPLQ
D
K
V
I
L
W
T
RVTP------TVS------
G
--
V
R
L
K
-
V
V
W
E
IS-T
D
N
Q
F
K
Q
N
L
K
----TGMVE----TSKTD
D
F
T
V
K
V
DAA--GLQA
D
T
V
Y
Y
Y
R
F
K
FG-----NKVSPVGQTKTLP---T---S---TN
K
V
S
F
A
V
C
SCSNY--------------P
A
G
-------------
Y
-------
F
Y
V
Y
----
R
E
----
M
-------
A
K--QN
V
D
V
I
I
HL
G
D
Y
I
Y
E
YGADGYA
T
E
D
A
I
K
LG-------RNLPADN----NK
E
I
I
K
L
N
D
Y
R
K
R
Y
A
L
Y
RQD
K
D
L
K
A
A
HQRH
P
F
I
V
I
WDD
H
E
L
A
N
D
-
A
W
R
EGAENHQSNEGVFS
D
-----
R
K
L
A
A
L
Q
A
Y
F
EWMPIRPVSS--TD--
H
---
L
N
I
Y
R
QFN-F------G
S
L
V
Q
L
T
MLD
T
R
I
I
ARDK
Q
L
A
Y
A
D
Y----MTTTGL-
D
I
A
K
F
Q
A
DL
T
-
N
P
V
R
T
L
M-GY
T
Q
R
D
W
------
L
V
D
K
L
K
Q---S---T--A--
T
W
N
V
V
G
Q
Q
V
L
M
S
KMW-I
P
A
E
L
L
A
S
L
G
Q
ITSGGT
S
P
D
A
L
A
K
M
N
A
Q
I
--
T
E
L
V
A
L
K
L
R
LQQNDPTL
T
A
Q
EK
A
--
R
I
M
T
VAPYNLDAWD
G
Y
Y
A
E
R
E
F
V
Y
D
K
L
A
EFN-K-
K
I
I
V
L
AGDT
H
N
A
W
A
S
Y
L
Y
----SQK----G
K
----
Y
V
G
V
E
L
ATSSVSSP
G
L
E
K
Y
L
SI
P
L
A
Q
L
Q
-
Q
F
E
F
---------
A
F
T
T
L
I
-
D
E
L
V
YC---NLNQR-------
G
Y
L
L
-----------
V
T
L
D
Q
------
V
Q
VHSE
W
R
F
V
D
SIKN
T
E
Y
Q
IDSSRQN
D
I
V
L
D
L
NLM--------PLKQGQKTA-------------------------------
33
Fugue
74.84
37%
34
- C3 -
-
2YEQ
23
PPBD_BACSU
A:
[1-522]
-----------------------------------------------------------
A
P
N
F
S
S
Y
P
F
T
L
--
G
V
A
S
G
D
P
L
S
D
S
V
V
L
W
T
R
L
A
P
------
D
P
L
NGGGMP
K
--
Q
A
V
P
-
V
K
W
E
V
A
-
K
D
E
H
F
R
K
I
V
R
----
K
G
T
E
M
----
A
K
P
S
L
A
H
S
V
H
V
E
A
D
--
G
L
E
P
N
K
V
Y
Y
Y
R
F
K
T
G
-----
H
E
L
S
P
V
G
K
T
K
T
L
P
APG
A
---
N
---
V
P
Q
M
T
F
A
F
A
S
C
Q
Q
Y
--------------
E
H
G
-------------
Y
-------
Y
T
A
Y
----
K
H
----
M
-------
A
K
--
E
K
L
D
L
V
F
H
L
G
D
Y
I
Y
E
Y
G
P
N
E
Y
V
S
K
T
------------
G
N
V
R
T
H
N
----
S
A
E
I
I
T
L
Q
D
Y
R
N
R
H
A
Q
Y
R
S
D
A
N
L
K
A
A
H
A
A
F
P
W
V
V
T
W
D
D
H
E
V
E
N
N
-
Y
A
N
K
I
P
E
K
G
Q
S
-
V
E
A
F
V
L
-----
R
R
A
A
A
Y
Q
A
Y
Y
E
H
M
P
L
R
I
S
S
L
--
P
N
GP
D
---
M
Q
L
Y
R
H
F
T
-
Y
------
G
N
L
A
S
F
N
V
L
D
T
R
Q
-
Y
R
D
D
Q
A
N
------------
N
D
-
G
N
K
P
P
S
D
E
S
R
-
N
P
N
R
T
L
L
-
G
K
E
Q
E
Q
W
------
L
F
N
N
L
G
S
---
S
---
T
--
A
--
H
W
N
V
L
A
Q
Q
I
F
F
A
K
W
N
-
F
G
T
S
-------------------------------------------------------
A
S
P
I
Y
S
M
D
S
W
D
G
Y
P
A
Q
R
E
R
V
I
N
F
I
K
S
K
N
L
N
-
N
V
V
V
L
T
G
D
V
H
A
S
W
A
S
N
L
H
----
V
D
F
----
E
K
TSSK
I
F
G
A
E
F
V
G
T
S
I
T
S
G
G
N
G
A
D
K
R
A
D
T
D
Q
I
L
-
K
E
------------------
N
P
H
I
Q
F
---
F
N
D
Y
R
-------
G
Y
V
R
-----------
C
T
V
T
P
------
H
Q
W
K
A
D
Y
R
V
M
P
F
V
T
E
P
G
A
A
I
--
S
T
R
A
S
F
V
Y
Q
K
D
Q
T
--------
G
L
R
K
V
S
S
T
T
I
Q
GGVKQSDEVEE
D
R
F
F
S
H
N
K
A
H
E
K
Q
M
I
K
K
R
13
HHSearch
71.46
37%
32
- C3 -
-
2YEQ
23
PPBD_BACSU
A:
[3-480]
------------------------------------------------------------
N
F
S
S
Y
P
-
F
T
L
--
G
V
A
S
G
D
P
L
S
D
S
V
V
L
W
T
R
L
A
P
------
D
P
L
NGGGMP
K
--
Q
A
V
P
-
V
K
W
E
V
A
-
K
D
E
H
F
R
K
I
V
R
----
K
G
T
E
M
----
A
K
P
S
L
A
H
S
V
H
V
E
A
D
--
G
L
E
P
N
K
V
Y
Y
Y
R
F
K
T
G
-----
H
E
L
S
P
V
G
K
T
K
T
L
P
---
A
---
P
GAN
V
P
Q
M
T
F
A
F
A
S
C
Q
Q
Y
--------------
E
H
G
-------------
Y
-------
Y
T
A
Y
----
K
H
----
M
-------
A
K
--
E
K
L
D
L
V
F
H
L
G
D
Y
I
Y
E
Y
G
P
N
E
Y
V
S
K
T
--
G
N
V
-------
R
T
H
--
N
S
-----
A
E
I
I
T
L
Q
D
Y
R
N
R
H
A
Q
Y
R
S
D
A
N
L
K
A
A
H
A
A
F
P
W
V
V
T
W
D
D
H
E
V
E
N
N
-
Y
A
N
K
I
P
E
K
G
Q
-
S
V
E
A
F
V
L
-----
R
R
A
A
A
Y
Q
A
Y
Y
E
H
M
P
L
R
I
S
S
L
PN
G
P
--
D
---
M
Q
L
Y
R
H
F
T
-
Y
------
G
N
L
A
S
F
N
V
L
D
T
R
Q
Y
R
-
D
D
Q
A
N
N
D
G
N
-------
K
------
P
P
S
D
E
S
R
-
N
P
N
R
T
L
L
-
G
K
E
Q
E
Q
W
------
L
F
N
N
L
G
S
---
S
---
T
--
A
--
H
W
N
V
L
A
Q
Q
I
F
F
A
K
W
N
-
F
G
T
S
-------------------------------------------------------
A
S
P
I
Y
S
M
D
S
W
D
G
Y
P
A
Q
R
E
R
V
I
N
F
I
K
S
K
N
L
N
-
N
V
V
V
L
T
G
D
V
H
A
S
W
A
S
N
L
H
----
V
D
F
EKTS
S
K
----
I
F
G
A
E
F
V
G
T
S
I
T
S
G
G
N
G
A
D
K
R
A
--
D
-----
T
D
Q
----------
I
L
K
E
N
-
P
H
I
Q
F
F
---
N
-
D
Y
R
-------
G
Y
V
R
-----------
C
T
V
T
P
------
H
Q
W
K
A
D
Y
R
V
M
P
F
V
T
E
P
G
A
A
I
S
T
R
A
S
F
V
Y
Q
K
D
----------------------------------------------------
12
PsiBlast_CBE
64.03
36%
56
- C3 -
-
2YEQ
2
PPBD_BACSU
B:
[9-414]
-------------------------------------------------------------------
F
T
L
--
G
V
A
S
G
D
P
L
S
D
S
V
V
L
W
T
R
L
A
P
DPLNGG
G
M
P
------
K
--
Q
A
V
P
-
V
K
W
E
V
A
-
K
D
E
H
F
R
K
I
V
R
----
K
G
T
E
M
----
A
K
P
S
L
A
H
S
V
H
V
E
A
D
--
G
L
E
P
N
K
V
Y
Y
Y
R
F
K
T
G
-----
H
E
L
S
P
V
G
K
T
K
T
L
P
---
A
PGA
N
---
V
P
Q
M
T
F
A
F
A
S
C
Q
Q
Y
--------------
E
H
G
-------------
Y
-------
Y
T
A
Y
----
K
H
----
M
-------
A
K
--
E
K
L
D
L
V
F
H
L
G
D
Y
I
Y
E
Y
G
P
N
E
Y
V
S
K
T
G
------------
N
V
R
T
H
N
----
S
A
E
I
I
T
L
Q
D
Y
R
N
R
H
A
Q
Y
R
S
D
A
N
L
K
A
A
H
A
A
F
P
W
V
V
T
W
D
D
H
E
V
E
N
N
-
Y
A
N
K
I
P
E
K
G
Q
S
V
E
-
A
F
V
L
-----
R
R
A
A
A
Y
Q
A
Y
Y
E
H
M
P
L
R
-
I
S
S
--
L
P
--
N
GPD
M
Q
L
Y
R
H
F
T
-
Y
------
G
N
L
A
S
F
N
V
L
D
T
R
Q
Y
-
R
D
D
Q
-------------
A
N
N
-
D
G
N
K
P
P
S
D
E
S
R
N
P
N
R
T
L
L
-
G
K
E
Q
E
Q
W
------
L
F
N
N
L
G
S
---
S
---
T
--
A
--
H
W
N
V
L
A
Q
Q
I
F
F
A
K
-
W
--------------
N
F
G
T
S
A
S
P
I
-----------------------------------------
Y
S
M
D
S
W
D
G
Y
P
A
Q
R
E
R
V
I
N
F
I
K
S
K
N
L
N
-
N
V
V
V
L
T
G
D
V
H
A
S
W
A
S
N
L
H
VDFE
K
T
S
----
S
K
----
I
F
G
A
E
F
V
G
T
S
I
T
S
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
63.66
36%
56
- C3 -
-
2YEQ
21
PPBD_BACSU
A:
[9-414]
-------------------------------------------------------------------
F
T
L
--
G
V
A
S
G
D
P
L
S
D
S
V
V
L
W
T
R
L
A
P
DPLNGG
G
M
P
------
K
--
Q
A
V
P
-
V
K
W
E
V
A
-
K
D
E
H
F
R
K
I
V
R
----
K
G
T
E
M
----
A
K
P
S
L
A
H
S
V
H
V
E
A
D
--
G
L
E
P
N
K
V
Y
Y
Y
R
F
K
T
G
-----
H
E
L
S
P
V
G
K
T
K
T
L
P
---
A
PGA
N
---
V
P
Q
M
T
F
A
F
A
S
C
Q
Q
Y
--------------
E
H
G
-------------
Y
-------
Y
T
A
Y
----
K
H
----
M
-------
A
K
--
E
K
L
D
L
V
F
H
L
G
D
Y
I
Y
E
Y
G
P
N
E
Y
V
S
K
T
G
------------
N
V
R
T
H
N
----
S
A
E
I
I
T
L
Q
D
Y
R
N
R
H
A
Q
Y
R
S
D
A
N
L
K
A
A
H
A
A
F
P
W
V
V
T
W
D
D
H
E
V
E
N
N
-
Y
A
N
K
I
P
E
K
G
Q
S
V
E
-
A
F
V
L
-----
R
R
A
A
A
Y
Q
A
Y
Y
E
H
M
P
L
R
-
I
S
S
--
L
P
--
N
GPD
M
Q
L
Y
R
H
F
T
-
Y
------
G
N
L
A
S
F
N
V
L
D
T
R
Q
Y
-
R
D
D
Q
-------------
A
N
N
-
D
G
N
K
P
P
S
D
E
S
R
N
P
N
R
T
L
L
-
G
K
E
Q
E
Q
W
------
L
F
N
N
L
G
S
---
S
---
T
--
A
--
H
W
N
V
L
A
Q
Q
I
F
F
A
K
-
W
--------------
N
F
G
T
S
A
S
P
I
-----------------------------------------
Y
S
M
D
S
W
D
G
Y
P
A
Q
R
E
R
V
I
N
F
I
K
S
K
N
L
N
-
N
V
V
V
L
T
G
D
V
H
A
S
W
A
S
N
L
H
VDFE
K
T
S
----
S
K
----
I
F
G
A
E
F
V
G
T
S
I
T
S
G
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
42.89
23%
-188
- C3 -
-
1G6U
1
?
A:
[1-47]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
A
L
K
S
E
L
Q
A
L
K
K
E
G
F
S
P
E
E
L
A
A
L
E
S
E
L
--
Q
A
L
E
K
K
L
A
A
L
K
S
K
L
Q
A
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
34.60
15%
-10
- C3 -
-
5UQ6
1
?
A:
[4-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
I
L
R
F
V
A
V
G
D
W
G
G
--------------
V
P
N
-------------
A
PFHT
A
R
E
M
A
N
A
----
K
A
I
A
T
T
V
-------
K
T
--
L
G
A
D
F
I
L
S
L
G
D
N
F
Y
F
T
G
V
H
D
--------------------------------
A
K
D
K
R
F
Q
E
T
F
E
D
V
F
S
D
----
P
S
L
R
N
V
P
W
H
V
L
A
G
N
H
D
H
L
G
N
-
V
S
A
Q
-----------
I
-----------
A
Y
S
K
I
S
K
R
W
N
------------
F
---
P
S
P
Y
Y
R
L
R
-
F
K
IPRSN
V
S
-
V
A
I
F
M
L
D
T
V
T
L
C
G
N
S
D
D
----
F
----
V
-----------
S
Q
Q
P
E
-
R
P
R
N
L
A
L
-
A
R
T
Q
L
A
W
------
I
K
K
Q
L
A
A
---
A
---
K
--
E
--
D
Y
V
L
V
A
G
H
Y
P
V
W
S
I
A
--------------------------------------------------------------------
E
H
G
P
T
H
C
L
V
K
Q
L
L
P
L
L
T
T
H
--
K
-
V
T
A
Y
L
C
G
H
D
H
N
L
Q
Y
L
Q
D
E
----
N
--------------
G
L
G
F
V
L
S
G
A
G
N
F
M
D
P
S
K
K
-----
H
-----------------
L
R
K
V
P
N
G
Y
L
R
F
H
F
G
A
E
N
S
L
G
-------
G
F
A
Y
-----------
V
E
I
T
P
------
K
E
M
S
V
T
Y
I
E
A
S
G
-----------------------------------------------------------------------
14
HHSearch
33.82
13%
-8
- C3 -
-
4KKZ
8
PPAF_PHAVU
A:
[19-326]
--------------------------------------------------------------
N
A
P
Q
-
Q
V
H
--
I
T
Q
G
D
L
V
G
R
A
M
I
I
S
W
V
T
M
D
E
------
P
G
S
-----------
S
A
-
V
R
Y
W
S
E
-
K
N
G
R
--
K
R
I
A
----
K
G
K
M
S
T
Y
R
F
F
N
Y
S
S
G
F
I
H
H
T
T
I
R
--
K
L
K
Y
N
T
K
Y
Y
Y
E
V
G
L
R
------
N
T
T
R
R
F
S
F
I
T
P
P
---
Q
---
T
GL-
D
V
P
Y
T
F
G
L
I
G
D
L
G
Q
--------------
S
F
D
-------------
S
-------
N
T
T
L
----
S
H
Y
E
--
L
-------
S
P
--
K
K
G
Q
T
V
L
F
V
G
D
L
S
Y
A
D
R
Y
P
N
------------------------------------
H
D
N
V
R
W
D
T
W
G
--
R
F
T
E
R
S
V
A
Y
Q
P
W
I
W
T
A
G
N
H
E
I
E
F
A
-
P
E
I
N
E
T
--------------------
E
P
F
K
P
F
S
Y
R
Y
H
V
P
Y
E
A
S
--
Q
S
--
T
---
S
P
F
W
Y
S
I
K
-
R
------
A
S
-
A
H
I
I
V
L
S
S
Y
S
A
Y
-------------------------------------
G
R
-
G
T
P
Q
Y
T
W
------
L
K
K
E
L
R
K
---
V
KRS
E
--
T
--
P
W
L
I
V
L
M
H
S
P
L
Y
N
S
Y
------------------------------------------------------------------
N
H
H
F
M
E
G
E
A
M
R
T
K
F
E
A
W
F
V
K
Y
K
---
V
D
V
V
F
A
G
H
V
H
A
Y
E
R
S
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
33.64
13%
-6
- C3 -
-
4DT2
5
PPAF_PHAVU
A:
[19-326]
--------------------------------------------------------------
N
A
P
Q
-
Q
V
H
--
I
T
Q
G
D
L
V
G
R
A
M
I
I
S
W
V
T
M
D
E
------
P
G
S
-----------
S
A
-
V
R
Y
W
S
E
-
K
N
G
R
--
K
R
I
A
----
K
G
K
M
S
T
Y
R
F
F
N
Y
S
S
G
F
I
H
H
T
T
I
R
--
K
L
K
Y
N
T
K
Y
Y
Y
E
V
G
L
R
------
N
T
T
R
R
F
S
F
I
T
P
P
---
Q
---
T
GL-
D
V
P
Y
T
F
G
L
I
G
D
L
G
Q
--------------
S
F
D
-------------
S
-------
N
T
T
L
----
S
H
Y
E
--
L
-------
S
P
--
K
K
G
Q
T
V
L
F
V
G
D
L
S
Y
A
D
R
Y
P
N
------------------------------------
H
D
N
V
R
W
D
T
W
G
--
R
F
T
E
R
S
V
A
Y
Q
P
W
I
W
T
A
G
N
H
E
I
E
F
A
-
P
E
I
N
E
T
--------------------
E
P
F
K
P
F
S
Y
R
Y
H
V
P
Y
E
A
S
--
Q
S
--
T
---
S
P
F
W
Y
S
I
K
-
R
------
A
S
-
A
H
I
I
V
L
S
S
Y
S
A
Y
-------------------------------------
G
R
-
G
T
P
Q
Y
T
W
------
L
K
K
E
L
R
K
---
V
KRS
E
--
T
--
P
W
L
I
V
L
M
H
S
P
L
Y
N
S
Y
------------------------------------------------------------------
N
H
H
F
M
E
G
E
A
M
R
T
K
F
E
A
W
F
V
K
Y
K
---
V
D
V
V
F
A
G
H
V
H
A
Y
E
R
S
E
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Fugue
32.24
17%
32
- C3 -
-
3WOL
7
DAPB2_PSEMX
A:
[1-696]
GEGMWVPQQLPE
I
A
G
P
L
K
K
A
G
L
KLS
P
Q
Q
I
S
D
L
T
G
D
P
M
G
A
V
V
A
L
G
G
C
T
A
S
F
V
S
P
N
G
L
V
V
T
N
H
H
C
A
Y
G
-
A
I
Q
L
N
S
T
A
E
N
N
L
I
K
N
G
F
N
A
P
T
T
A
D
E
------
V
S
A
------
G
PN
A
R
V
F
-
V
L
D
E
I
T
D
V
T
K
D
A
K
A
A
I
A
A
A
GD
D
A
L
A
R
----
T
K
A
L
E
A
F
E
K
K
L
I
A
D
C
E
A
E
A
G
F
R
C
R
L
Y
S
F
S
G
G
-----
N
T
Y
R
L
F
K
N
L
E
I
--------------
K
D
V
R
L
A
Y
A
P
P
G
S
V
G
K
FGGDIDNWMWPR
H
T
G
-------------
D
-------
F
A
F
Y
----
R
A
----
Y
V
G
KDG
K
P
A
A
--
F
S
K
D
N
V
P
Y
Q
P
K
H
W
L
K
F
A
D
Q
P
L
G
A
G
D
F
V
M
V
A
G
Y
P
G
S
TN
R
Y
A
L
A
A
E
----
F
D
N
T
A
Q
W
T
Y
P
T
I
A
R
H
Y
K
N
Q
I
A
M
V
E
A
A
G
K
Q
N
A
D
I
Q
V
K
--
Y
A
A
T
M
A
-
G
W
N
N
T
S
K
N
Y
D
G
Q
L
E
G
F
K
R
I
D
A
A
G
Q
K
L
R
E
E
A
A
V
L
G
W
L
K
G
Q
G
A
K
G
--
Q
P
--
A
---
L
D
A
H
A
K
L
--------------
L
D
L
L
E
Q
S
K
A
T
R
D
R
D
L
T
L
A
L
F
N
N
TA
M
L
G
S
A
T
-
Q
L
Y
R
L
S
I
E
R
E
-
K
P
N
A
E
R
E
S
G
Y
Q
E
R
D
L
P
A
I
E
G
G
L
K
Q
L
E
R
R
---
Y
---
V
--
A
--
A
M
D
R
Q
L
Q
E
Y
W
L
N
E
Y
I
K
L
P
A
D
Q
R
V
A
A
V
D
A
W
L
G
G
N
D
A
A
A
V
K
R
A
L
D
R
L
A
G
T
K
L
G
S
T
E
E
R
L
K
W
F
A
A
D
R
K
A
F
E
A
S
ND
P
A
I
Q
Y
A
V
A
V
M
P
T
L
L
K
L
E
Q
E
R
K
T
R
A
G
E
N
L
A
A
R
-
P
-
V
Y
L
Q
A
L
A
D
Y
K
K
S
Q
G
E
F
V
Y
P
D--
A
N
L
----
S
L
----
R
I
T
F
G
N
V
M
G
Y
A
P
K
D
G
M
E
Y
T
P
F
T
T
L
E
G
V
V
-
A
K
E
T
GQDPFDSP
K
A
L
L
D
A
V
-
A
A
K
R
Y
G
---
G
L
E
D
K
RIGSVPV
N
Y
L
S
D
L
D
I
T
GGNSG
S
P
V
L
D
A
HGKLV
G
L
A
F
D
G
N
W
E
S
V
S
S
N
----
W
V
F
D
P
K
M
T
R
M
I
A
V
D
G
R
Y
L
R
W
I
M
Q
EVY
P
A
P
Q
L
L
K
E
M
NV-----------------------------
25
HHSearch
31.61
13%
-35
- C3 -
-
5FC1
10
ASM3A_MOUSE
A:
[85-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
A
S
F
M
I
W
T
G
D
S
P
P
H
V
P
V
P
E
L
--------------------------------
S
T
G
T
V
I
K
V
I
T
N
M
T
--
M
T
V
Q
N
L
F
P
N
L
Q
V
F
P
A
L
G
N
H
D
Y
W
P
Q
-
D
Q
L
P
I
V
------
T
-
S
K
-------
V
Y
S
A
V
A
D
L
W
K
P
W
L
G
E
E
A
I
S
---
T
L
--
K
---
K
G
G
F
Y
S
Q
K
-
V
ASN---
P
G
-
L
R
I
I
S
L
N
T
N
L
Y
Y
G
P
N
I
--------------------------
M
--
T
L
N
K
T
D
-
P
A
N
Q
F
E
W
------
L
E
N
T
L
N
S
---
S
---
L
W
N
K
--
E
K
V
Y
I
I
A
H
V
P
V
G
Y
L
P
-
Y
A
-------------------------------------------------------------
T
D
T
P
A
I
--
R
Q
Y
Y
N
E
K
L
L
D
I
F
R
R
Y
S
-
S
V
I
A
G
Q
F
Y
G
H
T
H
R
D
S
L
M
V
L
S
----
D
K
N
----
G
N
----
P
L
N
S
V
F
V
A
P
A
V
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
31.13
13%
10
- C3 -
-
5EBB
3
ASM3A_HUMAN
B:
[43-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
G
D
V
L
C
D
S
P
--------------
Y
Q
L
-------------
I
-------
L
S
A
F
----
D
F
----
I
-------
K
N
SG
Q
E
A
S
F
M
I
W
T
G
D
S
P
P
H
V
P
V
P
E
L
--------------------------------
S
T
D
T
V
I
N
V
I
T
N
M
T
--
T
T
I
Q
S
L
F
P
N
L
Q
V
F
P
A
L
G
N
H
D
Y
W
P
Q
-
D
Q
L
P
V
V
------
T
-
S
K
-------
V
Y
N
A
V
A
N
L
W
K
P
W
L
D
E
E
A
I
S
---
T
L
--
R
---
K
G
G
F
Y
S
Q
K
-
V
TTN---
P
N
-
L
R
I
I
S
L
N
T
N
L
Y
Y
G
P
N
I
--------------------------
M
--
T
L
N
K
T
D
-
P
A
N
Q
F
E
W
------
L
E
S
T
L
N
N
---
S
---
Q
QN
K
--
E
K
V
Y
I
I
A
H
V
P
V
G
Y
L
P
-
S
S
-------------------------------------------------------------
Q
N
I
T
A
M
--
R
E
Y
Y
N
E
K
L
I
D
I
F
Q
K
Y
S
-
D
V
I
A
G
Q
F
Y
G
H
T
H
R
D
S
I
M
V
L
S
----
D
K
K
----
G
S
----
P
V
N
S
L
F
V
A
P
A
V
T
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
31.07
18%
29
* C4 *
-
4BIJ
-
TERL_BPT7
A:
[1-476]
------------
M
S
T
Q
S
N
R
N
A
L
----
V
V
A
Q
L
K
G
D
F
V
A
F
L
F
V
L
W
K
A
L
N
L
-----
P
----
V
P
T
K
C
Q
I
D
-
M
A
K
--
V
L
A
N
G
D
--
N
K
K
F
I
L
Q
A
F
R
G
I
------
G
K
S
------
F
--
I
T
C
A
F
V
V
W
S
L
W
-
R
D
P
Q
----
L
K
----
I
L
I
V
S
----
A
S
K
E
-----
R
A
D
A
N
--
S
I
F
I
K
N
I
I
D
L
L
P
F
L
S
-----
E
L
K
P
R
P
G
Q
R
D
S
V
I
---
S
---
F
---
D
V
G
P
A
N
P
D
H
S
P
S
V
K
--------------
S
V
G
-----------------------
I
T
----
G
Q
----
L
-------
T
G
--
S
R
A
D
I
I
I
A
D
D
V
E
I
P
S
N
S
A
T
M
G
A
R
E
K
L
W
T
L
V
-------
Q
E
F
A
A
L
L
K
P
LP
S
S
R
V
I
Y
L
G
T
P
Q
T
E
M
T
L
Y
K
E
L
E
D
N
R
G
Y
T
T
-----
I
I
W
P
A
L
Y
------------
P
R
T
R
E
E
N
L
Y
Y
S
-----
Q
R
L
A
M
L
R
A
E
Y
D
E
N
P
E
A
L
A
G
T
--
P
T
--
D
---
P
V
R
F
D
R
D
D
----------------
L
R
E
R
E
L
E
Y
G
K
A
G
F
T
L
Q
F
----
M
L
N
P
N
L
S
D
A
E
K
Y
P
L
R
L
R
-
D
A
I
V
A
A
L
-
D
L
E
K
A
--------------------------------------
M
H
Y
Q
W
-
L
P
N
R
Q
-
N
I
I
E
D
L
P
N
V
G
L
K
G
D
D
L
H
T
Y
H
D
C
S
--
N
N
S
G
Q
Y
Q
Q
K
I
L
V
I
D
P
S
G
R
G
K
D
E
T
--
G
Y
A
V
L
Y
T
L
N
---
G
Y
I
Y
L
M
E
A
G
G
F
R
D
G
---
Y
S
-
D
-
K
T
L
E
L
L
A
K
K
A
K
Q
W
G
V
Q
T
V
----
V
Y
E
----
S
N
----
F
G
D
G
M
F
G
K
--
V
F
S
P
I
L
L
K
H
H
N
C
A
M
E
E
I
R
-
A
-------------------------------------------------------------------
R
G
M
K
E
M
R
I
C
D
T
L
E
P
V
M
Q
T
H
R
L
V
I
R
D
E
V
-------------------------------------------------------
17
HHSearch
30.90
12%
20
- C3 -
-
3ZK4
1
?
C:
[195-468]
----------------------------------------------------------------------------------------------------------------------------------------------------
D
P
G
Y
I
H
T
S
F
L
K
--
E
L
W
P
N
R
E
Y
T
Y
K
L
G
H
R
L
FNG
T
T
I
W
S
K
E
Y
H
F
K
A
S
P
---
Y
---
P
GQ-
S
S
V
Q
R
V
V
I
F
G
D
M
G
K
--------------
A
E
A
DGSNEYNNFQPG-
S
-------
L
N
T
T
----
K
Q
----
I
-------
I
Q
D
L
E
D
I
D
I
V
F
H
I
G
D
L
C
Y
A
N
G
Y
I
S
----------------------------------------
Q
W
D
Q
F
T
--
A
Q
I
E
P
I
A
S
T
V
P
Y
M
T
A
S
G
N
H
E
R
D
W
P
-
G
T
G
S
F
Y
G
N
L
--------
D
-----
S
G
G
E
C
G
V
P
A
Q
T
M
F
F
V
P
A
E
-----
N
--
R
---
E
K
F
W
Y
S
T
D
-
Y
------
G
M
-
F
R
F
C
I
A
H
T
E
L
D
W
-------------------------------------
R
K
-
G
T
E
Q
Y
E
F
------
I
E
K
C
L
A
S
VDR
Q
---
K
--
Q
--
P
W
L
I
F
L
A
H
R
V
L
G
Y
S
S
-
A
G
------------------------------------------------------------
F
Y
V
Q
E
G
S
F
E
E
P
M
G
R
E
D
L
Q
H
L
W
Q
K
Y
K
-
V
--
D
I
A
M
Y
G
H
V
H
N
Y
E
R
T
C
P
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
30.55
12%
20
- C3 -
-
3ZK4
2
?
B:
[195-468]
----------------------------------------------------------------------------------------------------------------------------------------------------
D
P
G
Y
I
H
T
S
F
L
K
--
E
L
W
P
N
R
E
Y
T
Y
K
L
G
H
R
L
FNG
T
T
I
W
S
K
E
Y
H
F
K
A
S
P
---
Y
---
P
GQ-
S
S
V
Q
R
V
V
I
F
G
D
M
G
K
--------------
A
E
A
DGSNEYNNFQPG-
S
-------
L
N
T
T
----
K
Q
----
I
-------
I
Q
D
L
E
D
I
D
I
V
F
H
I
G
D
L
C
Y
A
N
G
Y
I
S
----------------------------------------
Q
W
D
Q
F
T
--
A
Q
I
E
P
I
A
S
T
V
P
Y
M
T
A
S
G
N
H
E
R
D
W
P
-
G
T
G
S
F
Y
G
N
L
--------
D
-----
S
G
G
E
C
G
V
P
A
Q
T
M
F
F
V
P
A
E
-----
N
--
R
---
E
K
F
W
Y
S
T
D
-
Y
------
G
M
-
F
R
F
C
I
A
H
T
E
L
D
W
-------------------------------------
R
K
-
G
T
E
Q
Y
E
F
------
I
E
K
C
L
A
S
VDR
Q
---
K
--
Q
--
P
W
L
I
F
L
A
H
R
V
L
G
Y
S
S
-
A
G
------------------------------------------------------------
F
Y
V
Q
E
G
S
F
E
E
P
M
G
R
E
D
L
Q
H
L
W
Q
K
Y
K
-
V
--
D
I
A
M
Y
G
H
V
H
N
Y
E
R
T
C
P
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
29.80
12%
-89
- C3 -
-
5I81
4
ASM_HUMAN
A:
[222-382]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
F
D
M
V
Y
W
T
G
D
I
P
A
H
D
V
W
H
Q
T
-----------------------------
R
Q
D
Q
L
R
A
L
T
T
V
T
------
A
L
V
R
K
F
L
G
P
V
P
V
Y
P
A
V
G
N
H
E
S
T
P
V
-
N
S
F
P
P
P
F
I
E
G
N
H
S
S
R
W
-------
L
Y
E
A
M
A
K
A
W
E
P
W
L
P
A
E
A
L
R
T
---
L
--
R
---
I
G
G
F
Y
A
L
S
P
Y
------
P
G
-
L
R
L
I
S
L
N
M
N
F
C
S
R
E
N
F
-----
W
----
L
------------------
L
I
N
S
T
D
-
P
A
G
Q
L
Q
W
------
L
V
G
E
L
Q
A
---
A
---
E
--
D
R
G
D
K
V
H
I
I
G
H
I
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
29.46
11%
-51
- C3 -
-
5FIB
8
ASM_MOUSE
A:
[193-353]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
F
E
M
V
Y
W
T
G
D
I
P
A
H
D
V
W
Q
Q
---------------------------------
S
R
Q
D
Q
L
R
A
L
T
T
I
T
--
D
L
V
R
K
F
L
G
P
V
P
V
Y
P
A
V
G
N
H
E
S
T
P
V
N
G
F
P
P
P
F
I
K
G
-
N
Q
S
S
Q
W
-------
L
Y
E
A
M
A
K
A
W
E
P
W
L
P
A
D
A
L
H
T
---
L
--
R
---
I
G
G
F
Y
A
L
T
-
P
R-----
P
G
-
L
R
L
I
S
L
N
M
N
F
C
S
R
E
N
F
-----
W
----------------------
L
L
I
N
S
T
D
-
P
A
G
Q
L
Q
W
------
L
V
E
E
L
Q
A
---
A
---
E
--
N
R
G
D
K
V
H
I
I
G
H
I
P
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
29.02
13%
-9
- C3 -
-
3D03
-
?
A:
[1-160]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
L
A
H
I
S
D
T
H
F
--------------
R
S
R
GEKLYGFID
V
N
A
A
N
-------
A
D
V
V
----
S
Q
----
L
-------
N
A
LR
E
R
P
D
A
V
V
V
S
G
D
I
V
N
C
G
R
P
E
E
----------------------------------
Y
Q
V
A
R
----
Q
-----
I
L
G
S
--
L
N
Y
P
L
Y
L
I
P
G
N
H
D
D
K
A
L
-
F
L
E
---------------------------
Y
L
Q
P
L
C
P
Q
L
G
S
-----
D
--
A
---
N
N
M
R
C
A
V
D
-
D
------
F
A
-
T
R
L
L
F
I
D
S
S
R
A
G
-
T
--------------------------------
S
K
G
W
L
-
T
D
E
T
I
S
W
------
L
E
A
Q
L
F
E
---
G
---
G
--
D
--
K
P
A
T
I
F
M
H
H
P
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
28.85
13%
-16
- C3 -
-
3D03
-
?
C:
[1-160]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
L
A
H
I
S
D
T
H
F
--------------
R
S
R
GEKLYGFIDVNAA
N
-------
A
D
V
V
----
S
Q
----
L
-------
N
A
LR
E
R
P
D
A
V
V
V
S
G
D
I
V
N
C
G
R
P
E
E
----------------------------------
Y
Q
V
A
R
----
Q
-----
I
L
G
S
--
L
N
Y
P
L
Y
L
I
P
G
N
H
D
D
K
A
L
-
F
L
E
---------------------------
Y
L
Q
P
L
C
P
Q
L
G
S
-----
D
--
A
---
N
N
M
R
C
A
V
D
-
D
------
F
A
-
T
R
L
L
F
I
D
S
S
R
A
G
-
T
--------------------------------
S
K
G
W
L
-
T
D
E
T
I
S
W
------
L
E
A
Q
L
F
E
---
G
---
G
--
D
--
K
P
A
T
I
F
M
H
H
P
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
28.76
16%
13
- C3 -
-
2BQ8
-
PPA5_HUMAN
X:
[3-187]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
L
R
F
V
A
V
G
D
W
G
G
--------------
V
P
N
-------------
A
PFHTARE
M
A
N
A
KEIA
R
T
----
V
-------
Q
I
--
L
G
A
D
F
I
L
S
L
G
D
N
F
Y
F
T
G
V
Q
D
I
--------------------------------
N
D
K
R
F
Q
E
T
F
E
D
V
F
S
D
----
R
S
L
R
K
V
P
W
Y
V
L
A
G
N
H
D
H
L
G
N
-
V
S
A
Q
I
----------------------
A
Y
S
K
I
S
K
R
W
N
F
P
S
------
P
--
F
---
Y
R
L
H
F
K
I
P
-
Q
TN----
V
S
-
V
A
I
F
M
L
D
T
V
T
L
C
G
N
S
D
-
D
---
F
----
L
S
-----------
Q
Q
P
E
-
R
P
R
D
V
K
L
-
A
R
T
Q
L
S
W
------
L
K
K
Q
L
A
A
---
A
---
R
--
E
--
D
Y
V
L
V
A
G
H
Y
P
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
27.85
17%
-15
- C1 -
-
4UQU
10
?
A:
[1-462]
------------
A
E
K
E
K
N
A
A
E
I
----
R
Q
Q
F
A
M
T
A
G
S
P
I
I
V
-------
N
D
--
K
L
E
----
R
Y
A
E
V
R
T
A
-
F
T
H
--
P
T
S
F
F
K
P
N
Y
K
G
-----
E
V
K
P
-------------------------
W
F
L
S
-
A
Y
D
E
K
V
R
Q
I
E
----
N
G
E
N
G
----
P
K
M
K
A
K
N
V
G
E
A
R
A
G
--
R
A
L
E
A
A
G
W
T
L
D
I
N
Y
G
-----
N
I
-----------------------------------
Y
--------------
P
N
R
-------------
F
-------
F
M
L
W
----
S
G
----
E
-------
T
M
--
T
N
T
Q
L
W
A
P
V
G
------------------
L
D
-------
R
R
P
P
--
D
----
T
T
D
P
V
E
L
T
N
Y
V
K
F
A
A
R
M
A
G
A
D
L
V
G
V
A
R
L
N
R
N
W
V
-------------
Y
S
E
A
V
T
I
P
A
D
V
P
Y
E
Q
S
L
-----
H
K
E
I
E
K
P
I
V
F
K
D
V
P
L
-
P
I
E
T
--
D
D
--
E
---
L
I
I
P
N
T
C
E
-
N
------
V
I
V
A
G
I
A
M
N
R
E
M
M
Q
T
A
P
N
S
M
A
C
A
T
T
----
A
F
C
Y
S
--
R
M
C
M
F
D
M
W
L
C
-
Q
F
I
R
Y
M
G
-
Y
Y
---------------------
A
---
I
--
P
--
S
C
N
G
V
G
Q
S
V
A
F
A
V
E
--------
A
G
L
G
Q
A
S
R
M
G
A
C
I
T
P
E
F
G
P
N
V
R
L
--
T
K
V
F
T
-
N
M
P
L
V
P
D
K
P
-------------------
I
D
F
--
G
V
T
E
F
C
E
T
C
K
K
C
A
R
E
C
P
-
S
-
K
A
I
T
E
G
P
R
T
F
E
G
--
R
S
I
H
----
N
Q
S
----
G
K
----
L
------------------------
Q
W
Q
N
D
Y
N
K
---------
C
L
G
Y
W
P
-
E
S
G
G
Y
C
---
G
V
C
V
A
-------
V
C
P
F
-----------
T
K
-
G
N
------
I
W
I
H
D
G
V
E
W
L
I
D
N
T
R
N
I
T
E
V
W
D
G
K
I
N
T
Y
G
L
D
A
D
H
F
--------
R
D
T
V
S
F
R
K
D
RVK----------------------------