@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VST3: (2017-12-10 )
MNIKEYDYIIIGAGSAGNVLAARLTEDKDTTVLLLEAGGPDYRLDFRTQMPAALAYPLQGRRYNWAYLTDPEPHMNNRRMECGRGKGLGGSSLINGMCYIRGNAMDLEQWATHKGLENWTYADCLPYYKKAETRDIGGNDYHGDSGPVSVATPKNGNNVLFHAMVEAGVQAGYPRTDDLNGYQQEGFGPMDRTVTPKGRRSSTARGYLDMAKGRPNLTILTHATTNKILFNQKQAIGVEYIIGADQNNLQRALVKREVLLCAGAIASPQILQRSGVGQSTFLKSMDIDVVHDLPGVGENLQDHLEMYLQYKCKQPVSLYPALKWYNQPAIGAEWLFNGTGIGASNQFEAGGFIRSSDEFKWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRSPSRGRIKLKSKDPFAHPSILFNYMSTEQDWREFRDAIRITREIMHQPALDPYRGDEISPGKHLQTDAELDDFVRNHAETAYHPSCSCKMGEDEMAVVDGQGRVHGMNGLRVVDASIMPLIITGNLNATTIMIAEKIADQIRGREALPRSTAPFYVAS
Atome Classification :
(20 SA)
.........10........20........30.......--------.40........50.....-.-..60........----70........80........90........100.......110.......120.......130-------......--.140.-----........150.......--..--160-.......170...------....180.--......190.......-200.......210..-......220.......230..----......240..-.....250....-...260.......270.......280.......290.......300..----.....310.-------......320----....--------....-330.......-340--.......350..-.....360....-.--..--370.......---380-.........-390......-.400......----.410----........420--.--......430.......440.....-------..450...-----....460..---.---....470.......480...--...-.-490.......500.......510.......520.......530.......540.......550
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNI
K
E
Y
D
Y
I
I
I
GAGSAG
N
V
L
A
A
RLTEDKD
T
T
V
L
L
L
EAG--------GPD
Y
R
L
D
F
RTQMP
A
A
LAY-P-LQGR
R
Y
N
W
A
Y
LT----DPEPHMNNRRMECGRGKGLG
G
S
S
LI
N
G
M
C
Y
IRGNAM
D
L
E
Q
W
A
T
HKGLENW
T
Y
A
D
C
L
P
Y
Y
KKAE-------TRDIGG--ND--Y-----HGDSG
P
V
S
V
--ATPKNGN--
N
V
--
L
F
H
-
A
M
V
E
A
G
VQAGYPR------TDDLNGYQ--QEGFGPMDRTVTPKGR-RSSTARGY
L
D
MA-KG-RP
N
L
T
I
L
T
HATTN
K
I
L
FN-QK----QAI
G
V
E
Y
I
IGA-DQ
N
N
L
Q
R
A
L
V
K
R
-
E
V
L
L
CAGAIA
S
P
Q
I
L
Q
RSGVG
Q
S
T
F
LKSMD
I
D
VVHDLPGV
G
E
N
L
Q
D
H
L
----
E
M
Y
L
Q
Y
KCK-------QPVSLY
P
A
-----
L
K
WY--------NQPA-IGA
E
W
L
FNGT-GIG--ASNQFEAGG
F
I
R-SSDEFKWPN
I
Q
Y
-
H
--
F
L
--
P
V
A
I
NYNGS
N
---
A
---
V
K
EHGFQAH-VGSMRSPSR-
G
R
I
K
LKSKDP----FA
H
-----
P
S
I
L
F
N
YMS
T
E
--
Q
--
D
W
R
E
F
R
D
A
I
R
I
T
R
E
I
M
HQPALDPY-------RGDEISPG-----KHLQ
T
D
A
E
L
---
D
---
D
F
V
R
N
H
A
E
TAYHPSCSCKMG--ED
E
-
M
-
A
V
VDGQG
R
V
HGMN
G
L
R
V
VDAS
I
M
P
L
I
I
TGNLN
A
T
T
I
M
I
A
E
K
I
A
D
Q
IRGREALPRSTA
P
F
Y
VAS
25
PsiBlast_CBE
66.03
33%
10
- C1 -
-
3NNE
1
CHOX_ARTGO
E:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
22
PsiBlast_CBE
65.93
33%
11
- C1 -
-
3NNE
1
CHOX_ARTGO
H:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
1
PsiBlast_PDB
65.82
34%
10
- C1 -
-
3LJP
1
CHOX_ARTGO
A:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
M
N
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
A
K
F
NTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
H
GY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
A
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
21
PsiBlast_CBE
65.79
34%
11
- C1 -
-
3LJP
1
CHOX_ARTGO
B:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
A
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
2
PsiBlast_PDB
65.75
33%
10
- C1 -
-
3NNE
1
CHOX_ARTGO
A:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
M
N
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
A
K
F
NTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HG
Y
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
A
V
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
24
PsiBlast_CBE
65.64
33%
11
- C1 -
-
3NNE
1
CHOX_ARTGO
F:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
23
PsiBlast_CBE
65.55
33%
10
- C1 -
-
3NNE
1
CHOX_ARTGO
G:
[9-529]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
--------------
107
HHSearch
65.53
32%
-19
- C1 -
-
4HA6
9
?
A:
[1-508]
----
N
C
D
I
V
I
V
G
G
G
S
A
G
S
L
L
A
A
R
L
S
E
D
P
D
S
R
V
L
L
I
E
A
G
--------
E
E
P
T
D
P
D
I
W
--
N
P
A
A
W
-
P
-
A
-
L
Q
G
R
S
Y
D
W
D
Y
R
T
----
E
A
Q
A
G
T
A
G
R
A
H
H
W
A
R
G
R
L
I
G
G
S
S
C
L
H
A
M
G
Y
M
R
G
H
P
S
D
F
Q
A
W
V
D
A
S
G
D
R
R
W
G
W
D
E
L
L
P
V
F
Q
A
I
E
-------
D
H
P
L
G
G
--
D
G
--
I
-----
H
G
K
G
G
P
L
P
I
--
H
L
P
A
D
E
V
--
S
P
--
L
A
R
-
A
F
I
E
A
G
A
S
L
G
L
P
R
------
L
E
G
H
N
S
G
E
--
M
I
G
V
T
P
N
S
L
N
-
I
R
D
G
R
-
R
V
T
A
A
D
A
W
L
T
K
A
-
V
R
G
R
K
N
L
T
I
L
T
G
S
R
V
R
R
L
K
L
E
-
G
N
----
Q
V
R
S
L
E
V
V
G
R
--
Q
G
S
--
A
E
-
V
F
A
D
-
Q
I
V
L
C
A
G
A
L
E
S
P
A
L
L
M
R
S
G
I
G
P
H
D
V
L
D
A
A
G
V
G
C
L
I
D
M
P
D
I
G
R
N
L
Q
D
H
L
----
L
G
A
G
N
L
Y
A
A
-------
R
K
P
V
P
----------
P
S
--------
R
L
Q
H
S
E
S
M
A
Y
M
--
R
A
-
D
S
------------
F
T
A
-
A
----
G
Q
P
E
I
V
V
-
G
CG
V
A
--
P
I
V
S
E
S
F
P
A
P
-------
A
A
G
S
A
Y
S
L
L
-
F
G
I
T
H
P
T
S
R
-
G
S
V
R
I
S
G
P
E
L
----
G
D
R
-----
L
I
I
D
P
A
Y
L
Q
T
G
--
R
--
D
R
E
R
F
R
R
A
L
E
A
S
R
T
I
G
H
R
D
E
L
A
G
W
-------
R
E
R
E
L
L
P
G
-----
T
P
-
N
S
A
A
E
M
---
D
---
D
F
I
A
R
S
V
I
T
H
H
H
P
C
G
T
C
R
M
G
--
K
D
P
-
D
-
A
V
V
D
A
N
L
R
L
K
A
L
D
N
L
F
V
V
D
A
S
I
M
P
N
L
T
A
G
P
I
H
A
A
V
L
A
I
A
E
T
F
A
R
Q
Y
H
H
H
H
-------------
26
PsiBlast_CBE
65.52
33%
11
- C1 -
-
3NNE
1
CHOX_ARTGO
D:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
27
PsiBlast_CBE
65.49
33%
7
- C1 -
-
3NNE
1
CHOX_ARTGO
C:
[9-528]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
---------------
28
PsiBlast_CBE
65.19
33%
12
- C1 -
-
3NNE
1
CHOX_ARTGO
B:
[9-530]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
A
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
-------------
103
HHSearch
65.13
35%
16
* C1 *
-
4MJW
5
CHOX_ARTGO
A:
[10-532]
-
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
-
R
W
M
--
E
-
L
L
E
S
G
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
G
-
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
PD
A
P
--
H
-----
H
G
D
S
G
P
V
H
L
--
M
N
V
-
P
P
K
--
D
P
--
T
G
V
-
A
L
L
D
A
C
E
Q
A
G
I
P
R
------
A
K
-
F
N
T
G
T
TV
V
N
G
A
N
F
F
Q
I
N
R
R
A
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
I
V
D
S
A
F
G
H
T
--
H
R
L
-
T
A
R
N
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
V
A
E
S
T
-------------------------
Q
W
W
--
E
I
-
G
I
F
--
T
P
T
E
---
D
G
L
--------
D
R
P
D
L
M
M
-
H
--
Y
G
SV
P
F
D
M
N
T
L
R
H
G
---
Y
P
--
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
EG
H
--
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
--
A
V
E
D
E
M
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
A
G
-----------
29
PsiBlast_CBE
65.04
33%
12
- C1 -
-
4MJW
5
CHOX_ARTGO
B:
[9-531]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
MN
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
AKFNTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
GH
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
A
------------
3
PsiBlast_PDB
64.73
33%
9
- C1 -
-
2JBV
2
CHOX_ARTGO
A:
[9-527]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
M
N
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
A
K
F
NTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HGY
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
----------------
4
PsiBlast_PDB
64.62
33%
10
- C1 -
-
4MJW
5
CHOX_ARTGO
A:
[9-532]
L
S
D
R
E
F
D
Y
I
V
V
G
G
G
S
A
G
A
A
V
A
A
R
L
S
E
D
P
A
V
S
V
A
L
V
E
A
G
--------
P
D
D
R
G
V
P
E
V
L
Q
L
D
R
W
M
E
L
-
L
-
E
S
G
--
Y
D
W
D
Y
P
I
----
E
P
Q
E
N
-
G
N
S
F
M
R
H
A
R
A
K
V
M
G
G
C
S
S
H
N
S
C
I
A
F
W
A
P
R
E
D
L
D
E
W
E
A
K
Y
G
A
T
G
W
N
A
E
A
A
W
P
L
Y
K
R
L
E
-------
T
N
E
D
A
G
--
P
D
AP
H
-----
H
G
D
S
G
P
V
H
L
M
N
V
P
P
K
D
P
T
--
G
V
------
A
L
L
D
A
C
E
Q
A
G
I
P
R
A
K
F
NTG
T
T
V
V
N
G
A
N
-----
F
F
Q
I
N
R
R
A
--
D
G
T
-
R
S
S
S
S
V
S
Y
I
H
P
I
-
V
E
-
Q
E
N
F
T
L
L
T
G
L
R
A
R
Q
L
V
F
D
A
D
R
----
R
C
T
G
V
D
-
I
V
D
S
-
A
F
G
H
T
H
R
L
T
A
R
N
-
E
V
V
L
S
T
G
A
I
D
T
P
K
L
L
M
L
S
G
I
G
P
A
A
H
L
A
E
H
G
I
E
V
L
V
D
S
P
G
V
G
E
H
L
Q
D
H
P
----
E
G
V
V
Q
F
E
A
K
-------
Q
P
M
-
V
A
E
S
-----
T
Q
W
W
----------------------------------
E
I
G
I
F
T
P
-
T
E
D
G
L
D
R
P
D
L
M
M
-
H
--
Y
G
--
S
V
P
F
D
M
N
T
L
R
HG
Y
P
---
T
T
E
N
G
F
S
L
T
-
P
N
V
T
H
A
R
S
R
-
G
T
V
R
L
R
S
R
D
F
----
R
D
K
-----
P
M
V
D
P
R
Y
F
T
D
P
--
E
G
H
D
M
R
V
M
V
A
G
I
R
K
A
R
E
I
A
A
Q
P
A
M
A
E
W
-------
T
G
R
E
L
S
P
G
-----
V
E
A
Q
T
D
E
E
L
---
Q
---
D
Y
I
R
K
T
H
N
T
V
Y
H
P
V
G
T
V
R
M
G
AV
E
D
E
-
M
-
S
P
L
D
P
E
L
R
V
K
G
V
T
G
L
R
V
A
D
A
S
V
M
P
E
H
V
T
V
N
P
N
I
T
V
M
M
I
G
E
R
C
A
D
L
I
R
S
A
R
A
G
-----------
18
PsiBlast_PDB
63.92
28%
7
- C1 -
-
1GPE
6
GOX_PENAG
A:
[23-579]
---
K
T
Y
D
Y
I
I
A
G
G
G
L
T
G
L
T
V
A
A
K
L
T
E
N
P
K
I
K
V
L
V
I
E
K
G
--------
F
Y
E
S
N
D
G
A
I
I
E
D
P
N
A
Y
G
--
Q
-
I
F
G
T
T
V
D
Q
N
Y
L
T
------
V
P
L
I
N
N
R
T
N
N
I
K
A
G
K
G
L
G
G
S
T
L
I
N
G
D
S
W
T
R
P
D
K
V
Q
I
D
S
W
E
K
V
F
G
M
E
G
W
N
W
D
N
M
F
E
Y
M
K
K
A
E
A
A
R
T
P
T
A
A
Q
L
A
A
G
--
H
S
--
F
NATC-
H
G
T
N
G
T
V
Q
S
--
G
A
R
D
N
G
Q
PW
S
P
--
I
M
K
-
A
L
M
N
T
V
S
A
L
G
V
P
V
------
Q
Q
D
F
L
C
G
H
--
P
R
G
V
S
M
I
M
N
N
L
D
E
N
Q
V
-
R
V
D
A
A
R
A
W
L
L
P
N
-
Y
Q
-
R
S
N
L
E
I
L
T
G
Q
M
V
G
K
V
L
F
K
-
Q
T
ASGP
Q
A
V
G
V
N
F
--
G
T
-
N
K
A
V
N
F
D
V
F
A
K
H
-
E
V
L
L
A
A
G
S
A
I
S
P
L
I
L
E
Y
S
G
I
G
L
K
S
V
L
D
Q
A
N
V
T
Q
L
L
D
L
P
-
V
G
I
N
M
Q
D
Q
T
----
T
T
T
V
S
S
R
A
S
SAG
A
G
Q
G
Q
A
V
F
F
A
N
F
-----
T
E
T
F
--------
G
D
Y
A
-
P
Q
A
R
D
L
L
N
T
K
L
D
Q
W
--
A
E
E
T
V
A
R
G
G
F
H
N
V
T
A
L
K
V
Q
Y
E
N
Y
R
N
-
W
--
L
L
--
D
E
D
V
A
F
A
E
L
F
---
M
---
D
T
E
G
K
I
N
F
D
-
L
W
D
L
I
P
F
T
R
-
G
S
V
H
I
L
S
S
D
P
YLWQ
F
A
N
D----
P
K
F
F
L
N
----
E
--
F
--
D
L
L
G
Q
A
A
A
S
K
L
A
R
D
L
T
S
Q
G
A
M
K
E
Y
-------
F
A
G
E
T
L
P
G
-----
Y
N
L
V
Q
N
A
T
L
S
Q
W
S
---
D
Y
V
L
Q
N
F
R
P
N
W
H
A
V
S
S
C
S
M
M
--
S
R
E
-
L
G
G
V
V
D
A
T
A
K
V
Y
G
T
Q
G
L
R
V
I
D
G
S
I
P
P
T
Q
V
S
S
H
V
M
T
I
F
Y
G
M
A
L
K
V
A
D
A
I
-----------------
9
PsiBlast_PDB
63.14
31%
11
- C1 -
-
4UDR
2
HMFO_METS6
A:
[5-527]
----
I
F
D
Y
V
I
V
G
G
G
T
A
G
S
V
L
A
N
R
L
S
A
R
P
E
N
R
V
L
L
I
E
A
G
IDTPENNI
P
P
E
I
H
D
G
L
R
P
W
L
P
R
-------
L
S
G
D
K
F
F
W
P
N
L
T
I
H
R
A
A
E
H
P
G
I
T
R
E
P
Q
F
Y
E
Q
G
R
L
L
G
G
G
S
S
V
N
M
V
V
S
N
R
G
L
P
R
D
Y
D
E
W
Q
A
-
L
G
A
D
G
W
D
W
Q
G
V
L
P
Y
F
I
K
T
E
R------
D
A
D
Y
G
D
--
D
P
--
L
-----
H
G
N
A
G
P
I
P
I
--
G
R
V
D
S
R
H
--
W
S
--
D
F
T
V
A
A
T
Q
A
L
E
A
A
G
L
P
N
------
I
H
D
Q
N
A
R
F
--
D
D
G
Y
F
P
P
A
F
T
L
--
K
G
E
E
R
F
S
A
A
R
G
Y
L
D
A
S
V
R
V
-
R
P
N
L
S
L
W
T
E
S
R
V
L
K
L
L
T
T
-
G
N
----
A
I
T
G
V
S
V
L
R
G
R
-
E
T
L
Q
V
Q
----
A
R
-
E
V
I
L
T
A
G
A
L
Q
S
P
A
I
L
L
R
T
G
I
G
P
A
A
D
L
H
A
L
G
I
P
V
L
A
D
R
P
G
V
G
R
N
L
W
E
H
S
----
S
I
G
V
V
A
P
L
T
-------
E
-------------
Q
A
R
--------
A
D
A
S
-
T
G
K
A
G
S
R
H
Q
L
-
G
I
R
--
A
S
S
G
V
D
P
A
---
T
-
P
S
D
L
F
------
L
-
H
--
I
----------
G
A
D
---
P
---
V
S
--
G
L
A
S
A
-
V
F
W
V
N
K
P
S
S
T
G
W
L
K
L
K
D
A
D
P
----
F
S
Y
-----
P
D
V
D
F
N
L
L
S
D
P
--
R
--
D
L
G
R
L
K
A
G
L
R
L
I
T
H
Y
F
A
A
P
S
L
A
K
Y
GLA
L
A
L
S
R
F
A
A
P
Q
P
G
GPL
L
N
D
L
L
Q
D
E
A
A
L
---
E
---
R
Y
L
R
T
N
V
G
G
V
W
A
A
S
G
T
A
R
I
G
R
A
D
D
S
-
Q
-
A
V
V
D
K
A
G
R
V
Y
G
V
T
G
L
R
V
A
D
A
S
I
M
P
T
V
P
T
A
N
T
N
L
P
T
L
M
L
A
E
K
I
A
D
A
I
-----------------
6
PsiBlast_PDB
63.00
32%
8
- C1 -
-
4HA6
9
?
A:
[3-503]
------
D
I
V
I
V
G
G
G
S
A
G
S
L
L
A
A
R
L
S
E
D
P
D
S
R
V
L
L
I
E
A
G
----------
E
E
P
T
D
P
D
I
W
N
P
A
A
--
W
-
P
A
L
Q
G
R
S
Y
D
W
D
Y
R
T
----
E
A
Q
A
G
T
A
G
R
A
H
H
W
A
R
G
R
L
I
G
G
S
S
C
L
H
A
M
G
Y
M
R
G
H
P
S
D
F
Q
A
W
V
D
A
S
G
D
R
R
W
G
W
D
E
L
L
P
V
F
Q
A
I
E
-------
D
H
P
L
G
G
--
D
G
--
I
-----
H
G
K
G
G
P
L
P
I
--
H
L
P
A
D
E
V
--
S
P
--
L
A
R
-
A
F
I
E
A
G
A
S
L
G
L
P
R
------
L
E
G
H
N
S
G
E
--
M
I
G
V
T
P
N
S
L
N
I
R
-
D
G
R
-
R
V
T
A
A
D
A
W
L
T
K
A
V
R
G
-
R
K
N
L
T
I
L
T
G
S
R
V
R
R
L
K
L
E
-
G
N
----
Q
V
R
S
L
E
V
V
--
G
-
R
Q
G
S
A
E
--
V
F
A
D
-
Q
I
V
L
C
A
G
A
L
E
S
P
A
L
L
M
R
S
G
I
G
P
H
D
V
L
D
A
A
G
V
G
C
L
I
D
M
P
D
I
G
R
N
L
Q
D
H
L
LGA
G
N
L
Y
A
A
R
K
P
V
-------
P
P
S
R
L
Q
H
S
E
S
M
A
Y
M
R
A
D
--------
S
F
T
A
-
A
G
Q
P
E
I
V
V
G
C
-
G
V
A
PI
V
S
E
S
F
P
A
--------------------------
P
A
A
----
G
S
------------
A
Y
S
L
L
-
F
G
I
T
H
P
T
S
R
-
G
S
V
R
I
S
G
P
E
L
----
G
D
R
-----
L
I
I
D
P
A
Y
L
Q
T
G
--
R
--
D
R
E
R
F
R
R
A
L
E
A
S
R
T
I
G
H
R
D
E
L
A
G
W
-------
R
E
R
E
L
L
P
G
-----
T
P
-
N
S
A
A
E
M
---
D
---
D
F
I
A
R
S
V
I
T
H
H
H
P
C
G
T
C
R
M
G
--
K
D
P
-
D
-
A
V
V
D
A
N
L
R
L
K
A
L
D
N
L
F
V
V
D
A
S
I
M
P
N
L
T
A
G
P
I
H
A
A
V
L
A
I
A
E
T
F
A
R
Q
------------------
31
PsiBlast_CBE
62.97
31%
7
- C1 -
-
4UDR
2
HMFO_METS6
B:
[5-527]
----
I
F
D
Y
V
I
V
G
G
G
T
A
G
S
V
L
A
N
R
L
S
A
R
P
E
N
R
V
L
L
I
E
A
G
IDTPENNI
P
P
E
I
H
D
G
L
R
P
W
L
P
R
-------
L
S
G
D
K
F
F
W
P
N
L
T
IHRA
A
E
H
P
G
I
T
R
E
P
Q
F
Y
E
Q
G
R
L
L
G
G
G
S
S
V
N
M
V
V
S
N
R
G
L
P
R
D
Y
D
E
W
Q
A
-
L
G
A
D
G
W
D
W
Q
G
V
L
P
Y
F
I
K
T
E
R------
D
A
D
Y
G
D
--
D
P
--
L
-----
H
G
N
A
G
P
I
P
I
--
G
R
V
D
S
R
H
--
W
S
--
D
F
T
V
A
A
T
Q
A
L
E
A
A
G
L
P
N
------
I
H
D
Q
N
A
R
F
--
D
D
G
Y
F
P
P
A
F
T
L
--
K
G
E
E
R
F
S
A
A
R
G
Y
L
D
A
S
V
R
V
-
R
P
N
L
S
L
W
T
E
S
R
V
L
K
L
L
T
T
-
G
N
----
A
I
T
G
V
S
V
L
R
G
R
-
E
T
L
Q
V
Q
----
A
R
-
E
V
I
L
T
A
G
A
L
Q
S
P
A
I
L
L
R
T
G
I
G
P
A
A
D
L
H
A
L
G
I
P
V
L
A
D
R
P
G
V
G
R
N
L
W
E
H
S
----
S
I
G
V
V
A
P
L
T
-------
E
-------------
Q
A
R
--------
A
D
A
S
-
T
G
K
A
G
S
R
H
Q
L
-
G
I
R
--
A
S
S
G
V
D
P
A
---
T
-
P
S
D
L
F
------
L
-
H
--
I
----------
G
A
D
---
P
---
V
S
--
G
L
A
S
A
-
V
F
W
V
N
K
P
S
S
T
G
W
L
K
L
K
D
A
D
P
----
F
S
Y
-----
P
D
V
D
F
N
L
L
S
D
P
--
R
--
D
L
G
R
L
K
A
G
L
R
L
I
T
H
Y
F
A
A
P
S
L
A
K
Y
GLALALS
R
F
A
A
P
Q
P
G
GPLLN
D
L
L
Q
D
E
A
A
L
---
E
---
R
Y
L
R
T
N
V
G
G
V
W
A
A
S
G
T
A
R
I
G
RA
D
D
S
-
Q
-
A
V
V
D
K
A
G
R
V
Y
G
V
T
G
L
R
V
A
D
A
S
I
M
P
T
V
P
T
A
N
T
N
L
P
T
L
M
L
A
E
K
I
A
D
A
I
-----------------
13
PsiBlast_PDB
62.77
29%
16
- C1 -
-
1CF3
5
GOX_ASPNG
A:
[18-575]
---
R
T
V
D
Y
I
I
A
G
G
G
L
T
G
L
T
T
A
A
R
L
T
E
N
P
N
I
S
V
L
V
I
E
S
G
----------
S
Y
E
S
D
R
G
P
I
I
E
D
L
N
A
Y
G
D
-
I
F
G
S
S
V
D
H
A
Y
E
T
-----
V
E
L
A
T
N
N
Q
T
A
L
I
R
S
G
N
G
L
G
G
S
T
L
V
N
G
G
T
W
T
R
P
H
K
A
Q
V
D
S
W
E
T
V
F
G
N
E
G
W
N
W
D
N
V
A
A
Y
S
L
Q
A
E
R
A
R
A
P
N
-
A
K
Q
I
A
A
--
G
H
--
Y
F
N
ASC
H
G
V
N
G
T
V
H
A
--
G
P
R
D
T
G
D
--
D
Y
SP
I
V
K
-
A
L
M
S
A
V
E
D
R
G
V
P
T
------
K
K
D
F
G
C
G
D
--
P
H
G
V
S
M
F
P
N
T
L
H
E
D
Q
V
-
R
S
D
A
A
R
E
W
L
L
P
N
-
Y
Q
-
R
P
N
L
Q
V
L
T
G
Q
Y
V
G
K
V
L
L
S
-
Q
N
GT
T
P
R
A
V
G
V
E
F
--
G
T
-
H
K
G
N
T
H
N
V
Y
A
K
H
-
E
V
L
L
A
A
G
S
A
V
S
P
T
I
L
E
Y
S
G
I
G
M
K
S
I
L
E
P
L
G
I
D
T
V
V
D
L
P
-
V
G
L
N
L
Q
D
Q
T
----
T
A
T
V
R
S
R
I
T
-------
S
A
G
A
G
Q
G
Q
-----
A
A
W
F
AT
F
N
E
T
F
G
D
Y
S
E
-
K
A
H
E
L
L
N
T
K
L
-
E
Q
W
--
A
E
E
A
V
A
R
G
G
F
H
N
-
T
T
A
L
L
----
I
Q
Y
E
N
--
Y
R
--
D
W
I
V
N
H
N
V
A
Y
---
S
E
L
F
L
D
T
A
G
V
A
S
F
D
V
W
D
L
L
P
F
T
R
-
G
Y
V
H
I
L
D
K
D
P
----
Y
L
H
H
F
A
Y
D
P
Q
Y
F
L
N
----
E
--
L
--
D
L
L
G
Q
A
A
A
T
Q
L
A
R
N
I
S
N
S
G
A
M
Q
T
Y
-------
F
A
G
E
T
I
P
G
-----
D
N
L
A
Y
D
A
D
L
---
S
A
W
T
E
Y
I
P
Y
H
F
R
P
N
Y
H
G
V
G
T
C
S
M
M
--
P
K
E
-
M
G
G
V
V
D
N
A
A
R
V
Y
G
V
Q
G
L
R
V
I
D
G
S
I
P
P
T
Q
M
S
S
H
V
M
T
V
F
Y
A
M
A
L
K
I
S
D
A
I
-----------------