@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSW0: (2017-12-10 )
MCRQITSFYSNDITNKTKVELDMSDTVIRDFFVSLGFSTDNEGARKMVDTLKGVELKAALLHKTLLLLATGAVVAVTKTASELDKLYYSSQRIGASASNIRAYGDAISQMGGNAQNALQSLENVAQKMRNSPGYEGMLTGMGVATRDGNGQLRDRVEVMKDLSKTMKGMDYYQANAYASSLGIDENTLMAMRDDKFIDNMEKYQKLRQSVGLTDELTKSGTDFMVEFRDITMTTKAITEVVVMTAGQVLIPVLKVINNFLRSAIAWFAELDPRFKAILATGLKFALLAIIFGGFIGTIAKLASVLPMLKSLLFLIKSLRLAFLASPIGIVLALAAAIAALWDDYQTWKNGGESLIDWSKWENGIETAISRIKQLAELIKSLKDKTVEFVTKAIDDPAGTAKETVAAVTEAAKTGTAAVVSATKSTVSTIKNNIASSTGFSQKYKSKNFTSDKAKTIEAVAKRIGVDPNDLAAVISFETSGTFSPSAKNPKSSATGLIQFMAGSGGTKGKYYGMSRKKFASLSFDEQMVYVEKYFKERGFKSSKKRDVADLYTAVTGYGYKKGSEAYELNKVWDSNKDGYIAKGEMVQNTSFKKHQRNYFTPNITSAPKVNISNTKNLANVGNPHKEQVNKSNASSANITIYQSHNTEMTINGADNPKETAQVVQRHNENTMIQMARNVKPLIG
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------------------------------------.........10........20------........30...-.....40-------........50...----------.-----------....60........70..----...---...--80........90.--.......100.......110........120.......130.......140....-----...150.......160...----....170.......180.......190.......200..------.....210.......-220---.....--.-.---.230----........240------........250------.--......--260.......270-.........280..--.....290.--....--..300--------..------......310......------.320.......330------.......340.......-350.......360-..----.......370....-...380.--------......390...-----....400.......410...----....420----........430--........440...--....450.......460.--......470...-------....480....--------------------------------------------...----------490.......500.....-------------..510..-----------.....520-------........------530-.........540.-------......550......--.-560--------......--..570..--.--....580.----------.----...---------------..590.......600.....-..610.......620.......630.......640.......650.......660.......670.......680.-----------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------------------------------------MC
R
Q
I
T
S
F
YSNDITN
K
T
K
V
E
L
------DM
S
D
T
V
I
R
D
F
F
V
S
-LGFSTD
N
-------
E
G
A
R
K
M
V
D
T
LKG
V
----------
E
-----------
L
K
A
A
L
L
H
K
T
L
L
L
LATG
A
V
----
V
A
V
---
T
K
T
--
A
S
E
L
D
K
L
Y
Y
SSQR--IGASAS
N
I
R
A
Y
G
D
A
I
S
QMG-G
N
A
Q
N
A
L
Q
S
L
E
N
V
A
Q
K
M
RNSPGYEGMLTGMGVATR-----DGN
G
Q
L
R
D
R
V
E
V
M
K
D
L
S
K
T
----MKGM
D
Y
Y
QANAYASSLGIDEN
T
L
M
AMRD
D
K
F
I
D
N
M
E
K
Y
Q
------
K
L
R
Q
SVG
L
T
D
E
L
TKS-GT----
D
F
M
V
E
--
F
-
R
---
D
I
T
-----
M
T
T
K
A
I
T
E
V
V
-------
V
MTA
G
Q
V
L
I
P
V
------
L
--
K
V
I
N
N
F
--
L
R
S
A
I
A
W
F
A
EL---
D
P
R
F
K
A
I
L
A
T
G
L
K
F
--
A
L
L
A
I
I
F
G
G
--
F
I
G
T
--
I
A
K
L
---------
A
S
------
V
L
P
M
L
K
S
L
L
F
L
I
K
S
L
------
R
L
A
F
LAS
P
I
G
I
V
L
A
------
L
A
A
A
I
A
A
L
W
D
D
Y
Q
T
W
K
N-GGESLI
D
W
S
K
W---E
N
----
G
I
E
T
A
I
S
R
I
K
Q
L
A
E
-
L
I
K
S
L
K
D
--------
K
T
V
E
F
V
T
K
AIDD-----PAG
T
A
K
E
T
V
A
A
V
T
E
AAKTG
T
----
A
A
V
V
S
A
-----
T
K
S
T
V
S
T
I
K
N
---
N
IASSTGFS
Q
K
YKS--KNFTS
D
K
A
K
T
I
E
A
V
A
K
R
I--GV
D
P
N
D
L
A
A
V
I
S
-------FETSGTFSPSA--------------------------------------------KNP----------KSSAT
G
L
I
Q
F
M
AGSGGTK-------------GKYYGMS-----------
R
K
K
F
ASL--------SF
D
E
Q
M
V
Y
------
V
---
E
K
Y
F
K
ERGFKSSK-------K
R
D
V
A
D
L
Y
T
A
V
TGYG--Y-KK---------GSEA
Y
E
--
L
N
K
VWDS--N--KDG
Y
I
AKG----------
E
----
M
VQ---------------NTSF
K
K
H
Q
RNYFTPNITSA
P
-
K
V
NISNTKNLANVGN
P
H
K
E
Q
VNKSNASSA
N
I
T
I
Y
QSHN
T
E
M
T
INGAD
N
P
K
E
T
A
Q
V
V
Q
R
HNE
N
T
M
I
Q
M
A
RNVKPLIG-----------------------------------------------------
63
Fugue
63.83
16%
13
- C2 -
-
3UGM
-
PTHX1_XANOP
A:
[169-1048]
--------------------------------KPKVRELVAHIVALSQHPAALGTVAVTYQHIITALAT
H
E
D
I
V
G
V
G
KQWSG
A
R
A
L
E
A
L
L
T
D
A
G
E
L
RGPPLQLDT
G
Q
L
V
K
I
A
K
R
GG
V
T
A
M
E
A
V
H
A
SRNALTPLNL
T
P
A
Q
V
V
A
I
A
S
N
---
N
G
G
K
Q
A
L
------
E
T
V
Q
R
L
L
P
V
L
C
Q
A
-
H
G
L
T
P
A
Q
V
V
A
I
A
SH
D
G
G
K
Q
A
L
E
T
M
Q
R
L
----------
L
-----------
P
V
L
C
Q
A
H
G
----
L
P
P
D
Q
V
----
V
A
I
A
SN
I
G
G
--
K
Q
A
L
E
T
V
Q
R
L
L
P
V
--
L
C
Q
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
H
G
-
G
-
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
-
P
D
Q
V
V
A
I
A
S
H
-----
D
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
----
A
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
-------
T
P
D
Q
V
V
A
I
A
S
N
G
G
K
Q
-
A
L
----
E
T
V
Q
R
--
L
-
L
---
P
V
L
CQAHG
L
T
P
D
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
------
L
--
C
Q
T
H
G
L
--
T
P
A
Q
V
V
A
I
A
S
H
---
D
G
G
K
Q
A
L
E
T
V
Q
Q
L
L
--
P
V
L
C
Q
A
H
G
L
--
T
P
D
Q
--
V
V
A
I
---------
A
S
NIG
G
K
Q
A
L
A
T
V
Q
R
L
L
P
V
L
C
Q
A
HGLTPD
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
------
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
-
T
P
D
Q
V
V
A
I
A
S
N
---
G
G
----
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
-
L
C
Q
A
H
G
L
--------
T
Q
V
Q
V
V
A
I
A
S
N
I
-----
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
A
Q
V
V
A
I
A
SHDG
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
A
H
G
L
T
P
D
Q
V
V
--
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
L
LP
G
L
T
Q
E
Q
V
V
A
I
A
S
NNGG
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
--------------------------------------------
C
Q
A
----------
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
G
G
G
K
Q
A
L
E
T
V
Q
R
LLPVL
C
Q
A
H
G
L
T
-----------
P
A
Q
V
V
A
I
A
SNIG
G
K
Q
A
L
E
T
V
Q
R
L
------
L
---
P
V
L
C
Q
D
H
G
L
T
-------------
L
A
Q
V
V
A
I
A
S
N
I
G
--
G
-
K
Q
---------
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
G
--
L
--
T
Q
D
Q
V
V
A
I
A
SNIG
G
K
Q
A
L
E
----
T
V
Q
---------------
R
L
L
P
V
L
C
Q
D
H
G
L
T
P
D
Q
V
V
A
I
-
A
S
N
I
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
L
D
Q
V
V
A
I
A
S
N
G
G
K
Q
A
L
E
T
V
Q
R
L
L
P
V
L
C
Q
D
H
G
L
T
P
D
Q
V
V
A
I
A
S
N
S
G
---------------------------------------------------------
61
Fugue
54.81
13%
50
- C3 -
-
2IPC
-
SECA_THET8
A:
[1-939]
MLGL
L
R
R
L
F
DN
N
E
R
E
I
A
R
Y
Y
K
Q
V
V
E
P
V
N
R
L
E
A
E
V
E
K
LPD
L
A
A
A
Y
R
E
L
K
E
K
H
E
K
GASLDEL
L
P
M
A
F
A
L
T
R
E
S
A
K
R
YLGMRHF
D
V
Q
L
I
G
G
A
V
L
H
E
G
K
I
A
E
M
K
T
G
E
G
K
T
L
V
A
T
L
A
V
A
L
N
A
L
TGK
G
V
H
V
V
T
VN
D
Y
L
A
R
R
D
A
E
W
M
G
P
V
Y
R
G
L
G
L
S
V
G
V
I
Q
H
------
A
S
T
P
A
E
R
R
K
A
Y
L
A
D
V
T
Y
V
T
N
S
-------
E
L
G
F
D
Y
L
R
D
N
M
A
I
----------
S
PDQLVLRHDHP
L
H
Y
A
I
I
D
E
V
D
S
I
L
I
D
E
A
R
----
T
P
L
---
I
I
S
G
P
A
E
K
A
T
D
L
Y
Y
K
M
A
E
--
I
A
K
K
L
E
R
G
L
P
A
E
P
G
V
R
K
E
P
-
T
G
D
Y
T
V
E
E
K
N
R
S
V
H
L
T
L
Q
G
I
A
K
A
E
K
L
L
G
I
E
G
L
F
S
P
-----
E
N
M
E
L
A
H
M
L
I
Q
A
I
R
A
K
E
L
Y
----
H
R
D
R
D
Y
I
V
Q
D
G
Q
V
I
I
V
D
E
F
T
G
R
L
M
P
G
R
--
R
Y
G
E
G
L
H
Q
A
I
------
E
A
K
E
G
V
R
I
E
R
E
N
Q
T
L
-
A
T
I
T
YQ
N
F
F
R
L
--
Y
E
K
---
R
A
G
-----
M
T
G
T
A
K
T
E
E
K
-------
E
F
Q
E
I
Y
G
M
-
D
V
------
V
--
V
V
P
T
N
R
--
P
V
I
R
K
D
F
P
D
V
V
---
Y
R
T
E
K
G
K
F
Y
A
V
V
E
E
--
I
A
E
K
Y
E
R
G
Q
P
V
L
V
G
T
IS
I
E
K
S
---------
E
R
------
L
S
Q
M
L
K
E
P
R
L
Y
L
P
R
L
------
E
M
R
L
E
L
F
K
K
A
S
Q
K
Q
------
Q
G
P
E
W
E
R
L
R
K
L
L
E
R
P
A
Q
L
K
D
E
D
L
A
P
F
E
G
L
IPP
K
G
----
N
L
R
T
A
W
E
G
L
K
R
A
V
H
-
T
L
A
V
L
R
Q
G
I
P
H
Q
V
L
N
A
K
H
H
A
R
E
A
E
I
V
A
-----
Q
A
G
R
S
K
-
T
V
T
I
A
T
N
M
A
G
R
G
T
----
D
I
K
L
G
G
-----
N
P
E
Y
L
A
A
A
L
L
---
E
K
E
G
F
D
R
Y
E
W
K
V
E
L
F
I
K
K
M
V
A
G
K
E
E
E
A
R
A
L
A
Q
E
L
--
G
I
R
E
E
L
L
E
R
I
R
E
-------
I
R
E
E
C
K
Q
D
E
E
R
--------------------------------------------
V
R
A
L
GGL
F
I
I
G
TE
R
H
E
S
R
R
I
D
N
Q
L
R
G
R
A
G
R
Q
-------------
G
D
P
-
G
G
S
-----------
R
---
F
Y
V
--------
S
F
D
D
D
L
M
R
LFAS
D
R
V
---
I
A
M
L
D
R
M
G
F
D
D
S
E
P
I
E
H
P
M
V
T
R
S
I
E
R
A
Q
K
R
V
E
D
R
N
--
F
-
A
I
---------
R
K
Q
L
L
Q
--
F
D
D
V
L
S
R
--
Q
--
R
E
V
I
Y
A
Q
R
----------
R
----
L
I
L
L
GK
D
E
E
V
K
E
A
A
I
G
M
V
E
E
T
V
A
S
L
A
E
N
F
L
N
P
E
V
H
P
E
D
W
D
L
E
G
L
K
A
T
L
L
D
T
A
P
Q
L
Q
D
F
P
F
A
E
L
R
A
L
K
A
E
E
A
V
E
R
L
V
E
A
A
L
K
A
Y
E
A
R
E
A
E
L
S
P
P
L
M
R
A
V
E
R
F
V
I
L
N
V
V
D
N
A
W
K
E
H
L
H
N
L
D
V
L
R
Q
G
IFLRGYGQKD
P
F
Q
E
Y
K
I
E
A
T
R
L
F
N
E
M
V
A
F
I
K
S
E
V
A
K
F
L
F
R
LKVE
60
Fugue
52.89
18%
26
- C3 -
-
4GA6
1
AMPPA_THEKO
A:
[1-493]
-------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
A
K
I
------
R
I
L
D
M
F
S
G
R
Y
T
V
L
-
I
---
N
E
E
-------
D
A
K
E
A
K
L
H
P
D
D
L
V
----------
K
-----------
I
E
A
G
K
K
A
V
Y
G
S
V
A
L
S
N
L
V
GKG
E
V
G
I
---
S
R
D
--
V
L
D
L
H
N
F
-----
S
--
E
G
E
T
V
S
V
I
P
A
--------------
G
T
P
E
S
V
R
Y
I
K
K
K
M
H
G
E
--------------------------
K
L
R
K
V
E
I
E
A
I
V
R
D
----
I
V
D
R
K
L
R
D
I
E
I
S
S
F
V
T
A
L
E
I
N
G
L
----------
D
M
D
E
I
A
------
A
L
T
I
A
M
A
E
T
G
D
M
L
D
I
-
D
R
----
K
P
I
M
D
--
V
-
H
S
IG
G
V
P
-----
G
N
K
T
N
I
L
V
V
P
-------
I
V
A
A
A
G
L
T
I
P
K
------
T
S
S
R
A
I
T
S
A
AG
T
A
D
V
V
E
V
F
A
D
V
---
S
F
S
L
D
E
I
K
R
I
V
E
K
V
--
G
-
A
C
L
V
W
G
G
-----------------------------
A
L
N
L
A
P
A
D
D
I
T
I
K
A
E
------
R
A
L
S
I
D
P
T
G
L
M
L
A
S
------
I
M
S
K
K
Y
A
M
--------
G
-
S
Q
Y
V
L
I
D
I
P
T
G
---
K
G
VKVE
T
V
E
E
A
R
S
L
A
R
D
F
I
E
-
L
G
K
R
L
-
G
--------
Q
Y
V
E
V
A
I
T
Y
G
G
Q
-----
P
I
G
---
H
T
V
G
P
A
L
E
A
R
E
A
L
S
----
A
L
M
T
--------------------------------------------------------
G
K
G
P
----------------------------------------------------------------------
G
S
L
----------
I
E
K
A
T
G
L
A
G
I
L
L
E
M
G
G
V
----------------------------------------------------------------------------------------------
A
P
A
G
T
G
--
K
-
K
M
---------
A
K
E
I
L
E
--
S
G
K
A
W
E
K
--
M
--
K
E
I
I
E
A
Q
G
----------
G
DPNI
K
P
E
---------------
E
I
P
I
G
D
K
T
Y
T
F
T
A
A
T
S
G
Y
V
T
-
A
I
D
N
R
A
I
T
A
I
A
R
A
A
G
A
P
E
D
K
-------
G
A
G
I
E
L
Y
V
K
V
G
E
K
V
K
---
E
G
D
P
L
F
T
I
H
A
E
H
E
A
R
L
D
Q
A
I
V
L
A
R
R
T
E
P
I
R
I
E----------------------------------------------------
18
PsiBlast_PDB
52.40
23%
-34
- C4 -
-
1AU4
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
52.35
15%
-3
- C1 -
-
5IFE
-
SF3B1_HUMAN
C:
[463-1304]
----------NLPFLKPDDIQYFDKLL
V
D
V
D
ESE
E
Q
K
E
R
K
I
M
K
L
L
L
K
I
K
N
GT
P
P
M
R
K
A
A
L
R
Q
I
T
D
K
A
REFG
A
G
P
L
F
N
Q
I
L
P
L
L
M
SPTLE
D
Q
E
R
H
L
L
V
K
V
I
D
R
I
L
Y
K
L
DDLVRPY
V
H
K
I
L
V
V
I
EPLLIDED
Y
Y
A
R
V
E
G
R
E
I
I
S
N
L
A
K
A
A
G
L
A
T
M
I
S
T
M
RPDID
N
M
D
E
Y
V
R
N
T
T
A
R
A
-
F
A
V
V
A
S
A
-------
L
G
I
P
S
L
L
P
F
L
K
A
V
C
K
SKKS
W
Q
A
R
H
-----------
T
G
I
K
I
V
Q
Q
I
A
I
L
M
G
C
A
I
L
----
P
H
L
---
R
S
L
--
V
E
I
I
E
H
G
L
V
D
E
Q
Q
K
V
R
T
I
S
A
L
A
I
A
A
L
A
E
A
A
T
P
Y
G
I
E
S
F
D
S
V
L
K
P
L
W
K
G
I
R
Q
H
R
G
-
K
G
L
A
A
F
L
K
A
I
G
Y
L
I
P
LMD
A
E
Y
A
N
Y
Y
T
R
E
V
M
L
I
L
I
R
E
F
Q
S
PD
E
E
M
K
K
I
V
L
K
V
V
K
Q
C
C
G
T
D
G
V
E
A
N
Y
I
K
T
E
I
L
P
P
F
F
K
H
F
W
Q
H
R
M
A
L
D
R
R
N
Y
R
Q
L
V
D
T
T
V
E
L
A
N
K
V
G
A
----
A
E
I
I
S
R
I
V
-
D
---
D
L
K
-----
D
E
A
E
Q
Y
R
K
M
V
-------
M
E
T
I
E
K
I
M
G
N
L
GAADID
H
--
K
L
E
E
Q
L
--
I
D
G
I
L
Y
A
F
Q
E
Q
TTE
D
S
V
M
L
N
G
F
G
T
V
V
N
A
L
G
K
R
V
K
P
Y
L
P
Q
--
I
C
G
T
--
V
L
W
R
L
N
NKSAKV
R
Q
Q
------
A
A
D
L
I
S
R
T
A
V
V
M
K
T
C
------
Q
E
E
K
L
M
G
H
L
G
V
V
L
Y
E
Y
LGEE
Y
P
E
V
L
G
S
I
L
G
A
L
K
A
I
V
N
-----
V
I
G
M
H
K
M
---
T
P
----
P
I
K
D
L
L
P
R
L
T
P
I
L
K
N
R
H
E
K
V
Q
E
--------
N
C
I
D
L
V
G
R
I
A
D
R
GAEYV
S
A
R
E
W
M
R
I
C
F
E
L
L
E
L
L
K
A
H
K
----
K
A
I
R
R
A
-----
T
V
N
T
F
G
Y
I
A
K
---
A
I
----
G
P
H
D
V
L
A
T
--
L
Q
N
R
V
C
T
T
V
A
I
A
I
V
A
E
T
----
C
S
P
F
T
V
L
P
A
L
M
-------
N
E
----
Y
R
V
P
E
--------------------------------------------
L
N
V
----------
Q
N
G
V
L
K
S
L
S
F
L
F
E
Y
I
G
E
M
-------------
G
K
D
Y
I
Y
A
-----------
V
T
P
L
L
E
D
--------
A
L
M
D
------------------
R
D
L
V
H
R
Q
T
A
-------
S
A
V
V
Q
H
M
S
L
G
V
Y
G
F
G
--
C
-
E
D
---------
S
L
N
H
L
---
L
N
Y
V
W
P
N
VF
E
--
T
S
P
H
V
I
Q
A
----------
V
----
M
G
A
---------------
L
E
G
L
R
V
A
I
---------------
G
P
C
R
M
L
Q
Y
C
L
Q
G
L
F
H
P
A
R
K
V
R
D
V
Y
W
K
I
Y
N
S
I
Y
I
G
S
Q
D
A
L
I
A
H
Y
P
R
I
Y
N
D
D
K
N
T
Y
I
R
Y
E
L
D
Y
I
L
----------------------------------------------------------------
10
PsiBlast_PDB
52.12
23%
-32
- C4 -
-
2ATO
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
51.91
23%
-24
- C4 -
-
1AU2
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
51.57
23%
-26
- C4 -
-
2BDL
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
51.56
23%
-33
- C4 -
-
1AYV
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.92
23%
-27
- C4 -
-
1MEM
2
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
50.81
23%
-36
- C4 -
-
1YT7
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
50.64
23%
-27
- C4 -
-
1YK7
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
50.58
23%
-25
- C4 -
-
2FTD
1
CATK_MACMU
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
50.55
23%
-31
- C4 -
-
1YK8
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
50.52
23%
-21
- C4 -
-
1AU3
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
50.40
22%
-2
- C4 -
-
4ANR
-
?
A:
[95-227]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
A
R
A
E
K
E
Y
--
G
V
P
A
E
I
I
V
S
I
I
G
-------
V
E
T
F
--
F
G
R
N
T
GSYR
V
M
D
A
L
S
T
L
G
F
DYPPR
A
D
F
F
R
K
E
L
R
E
F
L
L
L
A
R
E
Q
QVDPLS
L
T
G
S
----------
Y
A
G
A
M
G
L
P
Q
F
M
P
S
S
F
R
A
Y
-------------
A
V
D
F
D
G
D
-----------
G
H
-
I
N
I
W
S-------
D
P
T
D
A
I
G
S
------
V
---
A
S
Y
F
K
Q
H
G
W
V
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.31
23%
-27
- C4 -
-
1AYU
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.29
23%
-33
- C4 -
-
1TU6
2
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
50.27
23%
-16
- C4 -
-
1AU0
1
CATK_HUMAN
A:
[73-194]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
V
Q
K
N
R
--
G
I
D
S
E
D
A
Y
P
Y
V
G
-------
Q
E
E
S
C
M
Y
N
P
T
G
--------------------------------------------
K
A
A
----------
K
C
R
G
Y
R
E
I
P
----
E
G
N
E
K
-------------
A
L
K
R
A
V
A
-----------
R
V
G
P
V
S
V
--------
A
I
D
A
S
L
T
S
------
F
---
Q
F
Y
S
K
G
V
Y
Y
D
E
S
C
-------
N
S
D
N
L
N
H
A
V
L
A
V
G
Y
G
--
I
-
Q
K
---------
G
N
K
H
W
I
--
I
K
N
S
W
G
E
--
N
WG
N
K
G
Y
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
50.20
26%
13
- C4 -
-
3BKH
-
?
A:
[104-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
E
N
A
T
--
G
V
R
S
Q
L
L
L
T
F
A
S
-------
I
E
S
--
A
F
D
Y
E
I
--------------------------------------------
K
A
K
----------
T
S
S
A
T
G
W
F
Q
F
L
T
G
T
W
K
T
M
-------------
I
E
N
Y
G
M
K
YGVLTDPTGAL
R
K
D
-
P
R
I
--------
S
A
L
M
G
A
E
L
------
I
K
E
N
M
N
I
L
R
P
V
L
K
R
E
P
T
-------
D
T
D
L
Y
L
A
H
F
F
G
P
G
A
A
R
R
F
L
T
T
GQNEL
A
A
T
H
F
P
K
E
A
Q
--
A
N
P
S
I
F
Y
--
N
--
K
D
G
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------