@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VT04: (2017-12-11 )
MPIDTQLTTLFCLIDDFCTDITQNVEQYMLTYGQTKRLRQSKIHASGVITLLLWFHLTGSRNFKAFYLYWAKPFLCSYFTNLPSYSRFIELKAKYAMYFVALIESLKVHSAGIAFIDSTKLAVCHNKRIHQHRVFADSASRGKTSVDWFYGFKIHLICDHIGRLVSYCITTGNVDDCKVLPNLIEHSKLKGKLFGDRGYVGKNWKSRLAEVGVQLITRVKRNMKPQVLAPFDHAVLRKRGIIEAPFKLMKSQFDLEHSRHRSKMGLLTTIFAALTLYALVLVNGYKSGIQQILKPIDLNSA
Atome Classification :
(20 SA)
------------------------...-----......10........20...----.-------..------..30.-.......40...---.-----------------....50..------.....-.-60..--------------------......70...----------..-------------------...80....----....90...-....------.100.......----110....--...120----.....--.------..-------------------.130.......140.......150......-.160.......170.....-..180...------....190---.--..-....200...---------------------------....210....------...220..--..--..--.230...--....----240--.........250------....---....-260...-..-----------.-------.270----------........280.-......290.......300-----------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------MPI-----DTQ
L
T
T
L
F
C
L
I
D
D
F
C
T
D
I
T
Q
N
----
V
-------
E
Q
------
Y
M
L
T
Y-G
Q
T
K
R
L
R
Q
SKIH---
A
-----------------
S
G
V
I
T
L
L
L
------
W
FHLT-G-SR
N
F
--------------------
K
A
F
Y
L
Y
WA
K
P
F
----------
L
C
-------------------
S
Y
F
TNLP
S
Y
----
S
R
F
I
E
L
K
A
K
-
Y
A
M
Y
------
F
V
A
L
I
E
S
L
KVH----SA
G
I
A
F
I--DS
T
K
------
L
A
V
C
H--N------KR-------------------I
H
Q
H
R
VFADSASRGK
T
S
V
D
W
F
Y
G
F
K
I
H
L
I
C
-
D
H
I
G
R
L
V
S
Y
C
ITTGNV
D
D
C
-
K
V
L
P
N
L
I
E
------
H
S
KLK
G
K
---
L
--FG-DRGYVG
K
N
W
K
---------------------------
S
R
L
A
E
V
G
V
Q
L
I
------
T
R
V
K
RNMK--P
Q
--
V
L--APF
D
H
A
V
--
L
R
KR----G----I
I
E
A
P
F
K
L
M
K
-
S
------
Q
FD
L
---
E
H
S
R
-
H
R
S
KM
G
-
L
L
-----------
T
-------
T
I
F
-----------
A
A
L
T
L
Y
A
L
V
L
V
N
-
G
Y
K
S
G
I
Q
Q
I
L
K
PIDLNSA------------------------
26
Fugue
75.26
16%
-
- C3 -
-
4N74
-
?
A:
[264-577]
TQ
N
T
I
E
T
G
V
G
Y
S
TDV
G
P
R
V
K
A
T
W
K
K
P
W
VNSYG
H
S
L
T
T
S
T
S
I
S
A
P
E
Q
T
L
D
F
S
Y
K
----
M
P
L
LKNPL
E
Q
------
Y
Y
L
V
Q
-
G
G
F
K
R
T
D
L
N
D
T
E
---
S
-----------------
D
S
T
T
L
V
A
S
------
R
Y
W
D
L
-
S
-
S
G
W
Q
--------------------
R
A
I
N
L
R
W
S
V
D
H
----------
F
T
-------------------
Q
G
---------------
E
I
T
N
T
-
T
M
L
F
------
Y
P
G
V
V
I
S
R
T
R
S
----
R
G
G
L
M
P
T
W
G
D
S
Q
R
------
Y
S
I
D
Y
--
S
------
N
T
-------------------
A
W
G
S
D
V
D
F
S
V
F
Q
A
Q
N
V
W
I
R
T
L
Y
D
R
H
R
F
V
T
R
-
G
T
L
G
W
I
E
T
-------
G
D
F
D
-
K
V
P
P
D
L
R
F
------
F
A
G
G
D
R
S
---
I
--
R
G
Y
K
Y
K
S
I
A
P
K
Y
A
---------------------------
N
G
D
L
K
G
A
S
K
L
I
------
T
G
S
L
E
Y
Q
Y
--
N
V
--
T
---
G
K
W
W
G
A
V
--
F
V
D
S
----
G
------
E
A
V
S
D
I
R
R
-
S
------
D
F
K
T
G
T
G
V
G
V
R
-
W
E
S
P
V
G
-
P
I
-----------
K
-------
L
D
F
-----------
A
V
P
V
A
------
D
-
K
D
E
H
G
L
Q
F
Y
I
G
L
G
P
E
L
--------------------------
29
Fugue
72.78
19%
-
- C2 -
-
3NUH
-
GYRB_ECOLI
B:
[402-784]
---------------GLPGK
L
A
D
C
Q
E
R
-----
D
P
A
L
S
E
L
Y
L
V
E
G
D
S
A
G
G
S
A
K
Q
G
RNR
K
-------
N
Q
------
A
I
L
P
L
K
G
L
S
S
Q
E
V
A
T
L
I
T
---
A
L
GRYH
S
I
I
I
M
T
D
ADVDG
S
H
I
R
T
L
L
L
------
T
F
F
Y
R
-
Q
M
P
E
I
V
--------------------
E
R
G
H
V
Y
I
A
Q
P
P
----------
L
---------------------
Y
K
V
K
K
G
K
Q
----
E
Q
Y
I
K
D
D
E
A
M
D
Q
Y
Q
------
I
S
I
A
L
D
G
A
T
L
H
T
NAS
A
P
A
L
A
G
E
--
A
L
E
K
------
L
V
S
E
Y
--
N
------
A
T
Q
K
M
I
N
R
M
ERRYP
K
A
M
L
K
E
L
I
Y
Q
P
T
L
T
E
A
D
L
S
D
E
Q
T
V
T
R
W
V
N
A
L
V
S
E
L
N
D
K
E
Q
H
G
S
Q
W
K
F
D
V
H
T
N
A
L
F
E
P
-
I
V
R
---
V
R
------
T
H
G
V
D
T
D
---
Y
--
P
L
-
D
H
E
F
I
T
G
G
E
Y
---------------------------
R
R
I
C
T
L
G
E
K
L
R
G
L
LEE
D
A
F
I
E
R
G
E
R
--
R
Q
--
P
V
--
A
S
F
E
Q
A
L
D
W
L
V
K
E
----
S
R
R
G
L
S
I
Q
R
Y
K
G
L
G
E
M
N
------
P
E
Q
L
---
W
E
T
T
M
D
P
E
S
R
R
M
L
R
-----------
V
-------
T
V
K
-----------
D
A
I
A
A
D
Q
L
F
T
T
L
M
G
D
A
---------------------------------------
30
Fugue
45.57
17%
-26
- C4 -
-
4D08
1
PDE2A_HUMAN
A:
[4-342]
--------------------D
D
E
Y
T
K
L
-----
L
H
D
G
I
Q
P
V
A
A
I
D
S
N
F
A
S
F
T
Y
T
----
P
-------
R
S
LPEDD
T
S
M
A
I
L
-
S
M
L
Q
D
M
N
F
I
N
N
Y
---
K
-----------------
I
D
C
P
T
L
A
R
------
F
C
L
M
V
-
K
-
K
G
Y
R
--------------------
D
P
P
Y
H
N
W
M
H
A
F
----------
S
V
-------------------
S
H
F
C
Y
L
L
Y
K
N
LEL
T
N
Y
L
E
D
I
E
I
-
F
A
L
F
------
I
S
C
M
C
H
D
L
D
H
R
----
G
T
N
N
S
F
Q
--
V
A
S
K
S
V
----
L
A
A
L
Y
--
S
SEGS
V
M
E
R
-------------------
H
H
F
A
Q
A
I
A
I
L
N
T
H
G
C
N
I
F
D
H
F
S
R
K
D
Y
Q
R
M
L
-
D
L
M
R
D
I
I
L
A
--------------
T
D
L
A
H
------
H
L
R
I
F
K
D
---
L
Q
K
M
A
-
E
V
G
Y
D
R
N
N
-
K
---------------------------
Q
H
H
R
L
L
L
C
L
L
M
------
T
S
C
D
-----------
L
--
S
D
Q
T
K
G
W
--
K
T
T
R
----
K
----
I
A
E
L
I
Y
K
E
F
F
-
S
------
Q
G
D
L
---
E
K
A
M
-
G
N
R
P
M
E
-
M
M
DREKAY
I
P
E
L
Q
I
-------
S
F
M
-----------
E
H
I
A
M
P
I
Y
K
L
L
Q
-
D
L
F
P
K
A
A
E
L
Y
E
R
V
A
S
N
R
E
H
W
T
K
V
SHKFTIRGLPSNNSLDFLD
24
Fugue
43.90
19%
-18
- C1 -
-
4UX8
-
RET_HUMAN
A:
[1-480]
---------LYFSRD
A
Y
W
E
K
L
Y
V
D
Q
A
A
-----
G
T
P
L
L
Y
V
H
A
L
R
D
A
P
E
E
V
P
S
F
R
----
L
-------
G
Q
------
H
L
Y
G
T
-
Y
R
T
R
L
H
E
N
N
W
I
R
IQE
D
-----------------
T
G
L
L
Y
L
Q
R
S
L
D
H
S
S
W
E
K
L
S
V
R
-
N
R
G
F
PLL
T
V
Y
L
K
V
F
LSPCQWPG
C
A
R
V
Y
F
S
F
F
N
T
S
F
PACSSLK
P
R
E
L
C
FPE
T
R
P
S
F
R
I
R
E
NRPPGTF
H
Q
F
R
L
L
P
V
Q
----
F
L
C
P
Q
I
S
V
A
-
Y
R
L
L
EGEGLP
F
R
S
A
P
D
S
L
E
V
S
----
T
R
W
A
--
L
--
D
R
E
Q
RE
K
Y
E
L
V
A
V
C
T
V
H
R
------
E
E
-------------------
V
V
M
V
P
F
P
V
T
V
Y
D
E
D
D
S
A
P
T
F
P
A
G
V
D
T
A
S
A
V
-
V
E
F
K
R
K
E
D
T
V
V
A
T
L
R
V
F
D
A
-
D
V
V
P
A
S
G
E
LV
R
R
Y
T
S
T
L
L
P
G
D
---
T
--
W
A
-
Q
Q
T
F
R
V
E
H
W
P
NET
S
V
Q
A
N
G
S
F
V
RAT
V
H
D
Y
R
L
V
LNRNL
S
I
S
E
N
R
T
M
Q
L
A
------
V
L
V
N
D
S
L
H
LP
S
T
--
Y
S
--
L
S
V
S
R
R
A
--
R
R
F
A
----
Q
----
I
G
K
V
C
V
E
N
C
Q
-
A
FSGIN
V
Q
Y
K
L
---
H
S
S
G
A
N
C
S
T
L
G
-
V
V
-----------
T
SAEDTSG
I
L
F
V
N
DTKALRRPK
C
A
E
L
H
Y
M
V
V
A
T
D
-
Q
Q
T
S
R
Q
A
Q
A
Q
L
L
V
T
V
E
G
S
Y-----------------------
20
HHSearch
39.08
16%
-317
- C5 -
-
3F42
2
Y035_HELPY
A:
[40-70]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
V
S
F
-
N
G
L
G
E
L
V
D
L
Q
I
D
D
S
L
L
E
D
K
-
E
A
M
Q
I
Y
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
38.07
25%
-126
- C5 -
-
1TL7
1
GNAS2_BOVIN
C:
[128-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
V
L
T
S
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
37.16
25%
-146
- C5 -
-
1CJV
1
GNAS2_BOVIN
C:
[128-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
V
L
T
S
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
37.15
25%
-140
- C5 -
-
1CUL
1
GNAS2_BOVIN
C:
[114-205]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
V
L
T
S
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
37.08
25%
-142
- C5 -
-
1CJT
1
GNAS2_BOVIN
C:
[128-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
V
L
T
S
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
36.39
25%
-109
- C5 -
-
3SN6
-
GNAS2_BOVIN
A:
[114-212]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
VS--
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
36.16
25%
-138
- C5 -
-
1CJK
1
GNAS2_BOVIN
C:
[128-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
V
L
T
S
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
21
Fugue
34.86
17%
-83
- C5 -
-
5LSJ
-
PMF1_HUMAN
B:
[2-174]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
S
R
V
K
L
L
----
D
T
M
V
D
T
F
--
L
Q
K
L
------
V
A
A
G
S
--
Y
------
Q
R
-------------------
F
T
D
C
--
Y
K
C
F
Y
Q
L
Q
P
A
M
T
Q
Q
I
Y
D
K
F
I
A
Q
L
Q
-
T
S
I
R
E
E
I
S
D
I
K
E
E
G
N
L
E
A
V
L
N
A
L
D
K
I
V
E
------
E
G
K
V
R
K
E
---
P
A-
W
R
-
P
S
G
I
P
E
K
D
L
H
---------------------------
S
V
M
A
P
Y
F
L
Q
Q
R
------
D
T
L
R
R
H
V
Q
--
K
Q
E
A
E
N
--
Q
Q
L
A
D
A
V
--
L
A
G
R
----
R
----
Q
V
E
E
L
Q
L
Q
V
Q
-
A
------
Q
Q
Q
A
---
W
Q
A
L
-
H
R
E
Q
R
E
-
L
V
-----------
A
-------
V
L
R
-----------
E
------------------------------------------------------
9
PsiBlast_PDB
34.21
25%
-117
- C5 -
-
1CJU
1
GNAS2_BOVIN
C:
[128-219]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
Y
I
L
S
V
M
N
V
P
D
F
-
D
F
P
P
E
F
Y
E
------
H
A
K
A
L
W
E
---
D
--
E
G
-
V
R
A
C
Y
E
R
S
N
E
---------------------------
Y
Q
L
I
D
C
A
Q
Y
F
L
------
D
K
I
D
V
-
I
K
--
Q
D
--
D
Y
--
V
P
S
D
Q
D
L
--
L
R
C
R
V
L
T
S
G
----
I
F
E
T
K
F
Q
V
D
K
-
V
------
N
F
-----------------------------------------------------------------------------------------------------------
23
Fugue
29.99
18%
-227
- C5 -
-
1G2C
-
?
B:
[480-519]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
--
V
F
P
S
D
E
F
D
A
S
I
--
S
Q
V
N
----
E
----
K
I
N
Q
S
L
A
F
I
R
-
K
------
S
D
E
L
---
L
H
N
V
-
N
A
G
----------------------------------------------------------------------------------------------
15
HHSearch
24.08
13%
-50
- C5 -
-
2EZI
-
TNPA_BPMU
A:
[217-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
P
S
R
----
A
T
A
F
R
R
I
Q
Q
-
L
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
21.37
29%
-69
- C5 -
-
2PZJ
1
?
A:
[28-99]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
L
A
N
T
N
V
M
V
--
V
G
-
G
A
G
F
V
G
S
N
L
V
---------------------------
K
R
L
L
E
L
G
V
N
Q
V
------
H
V
V
D
N
L
L
S
--
A
E
--
K
I
--
N
V
P
D
H
P
A
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
21.09
29%
-56
- C5 -
-
2Q1T
1
?
A:
[26-99]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------
A
S
K
L
A
N
T
N
V
M
V
--
V
G
-
G
A
G
F
V
G
S
N
L
V
---------------------------
K
R
L
L
E
L
G
V
N
Q
V
------
H
V
V
D
N
L
L
S
--
A
E
--
K
I
--
N
V
P
D
H
P
A
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
20.90
15%
-245
* C5 *
-
2E74
1
PETL_MASLA
E:
[1-32]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
-
G
A
V
F
------
Y
I
V
F
I
A
L
F
F
G
I
----
A
V
G
I
I
F
A
--
I
K
S
I
------
K
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
20.56
15%
-243
- C5 -
-
4H13
1
PETL_MASLA
E:
[1-32]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
-
G
A
V
F
------
Y
I
V
F
I
A
L
F
F
G
I
----
A
V
G
I
I
F
A
--
I
K
S
I
------
K
L
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
20.43
29%
-63
- C5 -
-
2Q1U
1
?
A:
[26-95]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
------
A
S
K
L
A
N
T
N
V
M
V
--
V
G
-
G
A
G
F
V
G
S
N
L
V
---------------------------
K
R
L
L
E
L
G
V
N
Q
V
------
H
V
V
D
N
L
L
S
--
A
E
--
K
I
--
N
V
P
D
H
P
A
--
V
R
------------------------------------------------------------------------------------------------------------------------------------------