@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VT24: (2017-12-11 )
MGSSRGATGMSLSYQPTCSIDALKARAKLYTQIRQFFAERGVMEVETPVVSQAGVTDVHLASVQALRHINGKLQTQYLQTSPEFAMKRLLASGSGPIYQICKVFRDDEHGRKHNSEFTMLEWYRPGLDLKALMHETADLLQTCLQHRFGEVRPFILSYKHAFQDRLDINPLQATLKQLKDTANRVGLNLDLGDDRLAYMDLLFSHFFEPSLGFDAPVFLTDFPPEMASLAKVKLDEDGEEVAARFEVYIEGLELANAYDELLDSDVLRSRFEADNAERAKQGLHVMPLDEHLLAALPHMPECSGIALGVDRLLMVATDQLKIEKVIAFPAEIA
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------------.........10.....-...20........30........40........50.-.......60.......---.70...--..--...80........90........100.......-110.......120..-.....130.......140.....----------------------..-----------150-----------.---------------..-.-------------------....160---........170.--------------.-----.-------....180....----.--------.--.--190.....--..200.......210.......220.......230.......240.......250.......260.......270.......280.......290.....-.-.300.......310.......320.......330.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------------MGSSRGATGM
S
L
SYQP-TC
S
I
D
A
L
K
A
R
A
K
L
Y
T
Q
I
R
Q
F
F
A
ERGVMEVETPVVSQ-AGVT
D
V
H
L
A
S
V
Q
A
L
R
H
---ING
K
L
Q
--
T
Q
--
Y
LQT
S
P
E
F
A
M
K
R
L
L
ASGS
G
P
I
Y
Q
I
C
K
V
F
RDDEH-GRKHNSEF
T
M
L
E
W
YR-PGL
D
L
K
A
L
M
H
E
T
A
D
L
L
Q
T
C
L
Q
H
R----------------------FG-----------EV------------
R
---------------
P
F
-
I
-------------------
L
S
Y
K
H
-
A
---
F
Q
DRLDI
N
P
L
Q
A
--------------
T
-----
L
-------
K
Q
L
K
D
T
A
N
RV
G
----
L
--------
N
--
L
--DLGD
D
R
L
A
--
Y
M
D
L
L
F
S
H
FFEPSLGFDA
P
V
F
L
TDF
P
P
E
M
A
S
L
A
K
V
KLDED
G
E
E
V
A
A
R
F
E
V
Y
I
E
G
L
E
L
A
N
A
Y
D
E
L
L
D
S
D
V
L
R
S
R
FEAD
N
A
E
R
A
KQG
L
H
V
MP
L
D
E
H
L
L
A
ALP-H-MPECS
G
I
A
L
G
V
D
R
L
L
M
VATDQ
L
K
I
E
K
V
IAFPAEIA
47
HHSearch
82.02
47%
1
- C8 -
-
3A5Z
1
EPMA_ECOLI
C:
[11-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
G
P
G
H
S
Q
G
-
M
--
N
L
--
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
-----------------------------------
A
A
------------
E
---------------
S
L
----------------------
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
--
N
VA
D
T
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
--
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
24
PsiBlast_CBE
81.42
46%
9
- C8 -
-
3A5Z
1
EPMA_ECOLI
G:
[9-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
G
--
Q
--
G
M
NL
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
NV
A
--
D
T
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
26
PsiBlast_CBE
81.30
46%
11
- C8 -
-
3A5Z
1
EPMA_ECOLI
C:
[9-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
G
H
S
Q
--
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
NV
A
--
D
T
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
55
HHSearch
81.20
47%
-3
- C8 -
-
3A5Y
1
EPMA_ECOLI
C:
[31-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
GP----
G
-
M
--
N
L
--
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
-----------------------------------
A
A
------------
E
---------------
S
L
----------------------
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
--------
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
--
T
E
D
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
25
PsiBlast_CBE
80.94
46%
9
- C8 -
-
3A5Z
1
EPMA_ECOLI
E:
[9-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
G
H
S
Q
--
G
M
NL
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
NV
A
--
D
T
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
3
PsiBlast_PDB
80.69
46%
9
- C8 -
-
3A5Z
1
EPMA_ECOLI
A:
[9-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
G
H
S
Q
--
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
NV
A
--
D
T
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
23
PsiBlast_CBE
80.44
46%
-5
- C8 -
-
3A5Y
1
EPMA_ECOLI
B:
[26-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
G
H
S
Q
--
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
---------------------------
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
22
PsiBlast_CBE
80.33
46%
-6
- C8 -
-
3A5Y
1
EPMA_ECOLI
C:
[26-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
------
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
V
A
A
K
L
D
----
L
--------
S
--------
E
D
R
D
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
21
PsiBlast_CBE
79.93
47%
-3
- C8 -
-
3G1Z
1
EPMA_SALTY
B:
[6-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
F
P
F
E
T
R
F
V
---
G
P
---
Q
G
I
N
L
--
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
Q
----------------------
P
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
Q
R
H
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
A
A
A
K
L
D
----
L
----------------
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
M
G
V
E
P
H
I
G
K
E
K
P
T
F
I
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
---
R
G
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
-
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
T
V
D
R
A
1
PsiBlast_PDB
79.18
47%
6
- C8 -
-
3G1Z
1
EPMA_SALTY
A:
[6-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
F
P
F
E
T
R
F
V
---
G
---
S
Q
G
I
N
L
--
Y
L
M
T
S
P
E
Y
H
M
K
R
L
L
A
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
H
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
Q
----------------------
P
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
Q
R
H
L
E
I
D
P
L
S
A
--------------
D
-----
K
-------
T
Q
L
R
E
A
A
A
K
L
D
----
L
--------
S
N
I
A
--
D
T
E
E
D
R
D
T
--
L
L
Q
L
L
F
T
M
G
V
E
P
H
I
G
K
E
K
P
T
F
I
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
-
L
P
Q
Q
P
I
D
Q
N
L
L
D
A
L
A
-
A
G
L
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
S
L
A
D
V
I
A
F
T
V
D
R
A
2
PsiBlast_PDB
76.34
46%
-7
- C8 -
-
3A5Y
1
EPMA_ECOLI
A:
[26-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
W
Q
P
-
S
A
S
I
P
N
L
L
K
R
A
A
I
M
A
E
I
R
R
F
F
A
D
R
G
V
L
E
V
E
T
P
C
M
S
Q
-
A
T
V
T
D
I
H
L
V
P
F
E
T
R
F
V
---
G
P
G
H
S
Q
--
G
M
N
L
W
L
M
T
S
P
E
Y
H
M
K
R
L
L
V
A
G
C
G
P
V
F
Q
L
C
R
S
F
R
N
E
E
M
-
G
R
Y
H
N
P
E
F
T
M
L
E
W
Y
R
-
P
H
Y
D
M
Y
R
L
M
N
E
V
D
D
L
L
Q
Q
V
L
D
C
P
----------------------
A
A
-----------
E
S
---------------------------------------------------
L
S
Y
Q
Q
-
A
---
F
L
R
Y
L
E
I
D
P
L
S
A
--------------
D
--------------------------------------------------
T
--
L
L
Q
L
L
F
T
F
G
V
E
P
N
I
G
K
E
K
P
T
F
V
Y
H
F
P
A
S
Q
A
S
L
A
Q
I
S
T
E
D
--
H
R
V
A
E
R
F
E
V
Y
Y
K
G
I
E
L
A
N
G
F
H
E
L
T
D
A
R
E
Q
Q
Q
R
F
E
Q
D
N
R
K
R
A
A
R
G
L
P
Q
H
P
I
D
Q
N
L
I
E
A
L
K
V
G
-
M
P
D
C
S
G
V
A
L
G
V
D
R
L
V
M
L
A
L
G
A
E
T
L
A
E
V
I
A
F
S
V
D
R
A
11
PsiBlast_PDB
69.56
29%
-3
- C8 -
-
5ELN
6
?
A:
[188-518]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
K
V
F
K
L
R
S
R
A
I
K
Y
I
R
N
Y
F
D
R
L
G
F
L
E
V
E
T
P
M
L
N
M
-
I
----
Y
G
G
A
A
A
R
P
F
I
T
---
Y
H
N
E
L
E
--
T
Q
L
-
Y
M
R
I
A
P
E
L
Y
L
K
Q
L
I
V
G
G
L
D
K
V
Y
E
I
G
K
N
F
R
N
E
G
I
-
D
L
T
H
N
P
E
F
T
A
M
E
F
Y
M
-
A
Y
A
D
Y
Y
D
L
M
D
L
T
E
E
L
I
S
G
L
V
L
E
I
----------------------
H
G
-----------
S
L
------------
K
I
P
Y
H
PDGPE
G
K
C
I
E
I
D
F
-
T
-------------------
T
P
W
K
R
F
S
---
F
V
E
E
I
E
-
S
G
L
G
E
--------------
K
-----
L
-------
K
R
P
L
D
S
Q
E
N
I
D
----
F
M
V
E
M
C
E
K
H
E
--
I
--
E
L
P
H
P
R
T
A
A
K
L
L
D
K
L
A
G
H
F
V
E
T
K
C
--
T
N
P
S
F
I
I
D
H
P
Q
T
M
S
P
L
A
K
--
W
H
R
E
K
P
E
M
T
E
R
F
E
L
F
V
L
G
K
E
L
C
N
A
Y
T
E
L
N
E
P
L
Q
Q
R
K
F
F
E
Q
Q
A
D
A
K
A
S
G
D
V
E
A
C
P
I
D
E
T
F
C
L
A
L
E
-
H
G
L
P
P
T
G
G
W
G
L
G
I
D
R
L
I
M
F
L
A
D
K
N
N
I
K
E
V
I
L
F
P
A
---
12
PsiBlast_PDB
69.41
29%
0
- C8 -
-
5ELO
2
?
A:
[188-518]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
K
V
F
K
L
R
S
R
A
I
K
Y
I
R
N
Y
F
D
R
L
G
F
L
E
V
E
T
P
M
L
N
M
-
I
----
Y
G
G
A
A
A
R
P
F
I
T
---
Y
H
N
E
L
E
--
T
Q
L
-
Y
M
R
I
A
P
E
L
Y
L
K
Q
L
I
V
G
G
L
D
K
V
Y
E
I
G
K
N
F
R
N
E
G
I
-
D
L
T
H
N
P
E
F
T
A
M
E
F
Y
M
-
A
Y
A
D
Y
Y
D
L
M
D
L
T
E
E
L
I
S
G
L
V
L
E
I
----------------------
H
G
-----------
S
L
------------
K
I
P
Y
H
PDGPE
G
K
C
I
E
I
D
F
-
T
-------------------
T
P
W
K
R
F
S
---
F
V
E
E
I
E
-
S
G
L
G
E
--------------
K
-----
L
-------
K
R
P
L
D
S
Q
E
N
I
D
----
F
M
V
E
M
C
E
K
H
E
--
I
--
E
L
P
H
P
R
T
A
A
K
L
L
D
K
L
A
G
H
F
V
E
T
K
C
--
T
N
P
S
F
I
I
D
H
P
Q
T
M
S
P
L
A
K
--
W
H
R
E
K
P
E
M
T
E
R
F
E
L
F
V
L
G
K
E
L
C
N
A
Y
T
E
L
N
E
P
L
Q
Q
R
K
F
F
E
Q
Q
A
D
A
K
A
S
G
D
V
E
A
C
P
I
D
E
T
F
C
L
A
L
E
-
H
G
L
P
P
T
G
G
W
G
L
G
I
D
R
L
I
M
F
L
A
D
K
N
N
I
K
E
V
I
L
F
P
A
---
58
Fugue
67.58
27%
22
- C8 -
-
1LYL
1
SYK2_ECOLI
A:
[14-502]
F
N
D
E
L
R
N
R
R
E
K
L
A
A
L
R
Q
Q
GVAFPNDFRRDHT
S
D
Q
L
H
E
E
FDAKD
N
Q
E
L
E
S
L
NI
E
V
S
V
A
G
R
MM
T
R
R
I
MGK
A
S
F
V
T
L
Q
D
VG
G
R
I
Q
L
Y
V
A
RDSLPEGVYNDQFKKWDLG
D
I
I
G
A
R
G
T
L
F
K
T
QTG
E
L
S
I
HCT
E
L
R
L
LTKALRPLP
D
Q
E
V
R
Y
R
Q
R
Y
L
D
L
I
A
N
-
D
K
S
R
Q
T
F
V
V
R
S
K
I
L
A
A
I
R
Q
F
M
V
A
R
G
F
M
E
V
E
T
P
M
M
Q
V
-
I
P
G
G
A
---
S
A
R
P
F
I
T
H
---
H
N
A
L
D
L
--
D
M
--
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
-I
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
A
Y
A
-
D
Y
H
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
E
V
----------------------
L
G
---------------------------------------------TT
K
V
T
Y
GE
H
V
F
D
FG
K
P
F
E
K
L
T
M
R
E
-
A
---
I
K
K
Y
R
P
E
T
D
M
A
D
--------------
L
D
N
---
F
-------
D
A
A
K
A
L
A
E
S
I
G
----
I
--------
T
--
V
--
E
K
S
W
G
L
G
R
--
I
V
T
E
I
F
D
E
V
A
E
A
H
L
I
--
Q
P
T
F
I
T
E
Y
P
A
E
V
S
-
P
L
-
A
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
E
R
F
Q
E
Q
V
N
A
K
A
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
-
Y
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
I
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
M
R
P
4
PsiBlast_PDB
67.42
29%
-3
- C8 -
-
1BBU
1
SYK1_ECOLI
A:
[179-499]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
N
T
F
K
V
R
S
Q
I
L
S
G
I
R
Q
F
M
V
N
R
G
F
M
E
V
E
T
P
M
M
Q
----
V
I
P
G
G
A
A
A
R
P
F
I
T
H
---
H
N
A
L
D
L
--
D
M
--
Y
L
R
I
A
P
E
L
Y
L
K
R
L
V
V
G
G
F
E
R
V
F
E
I
N
R
N
F
R
N
E
G
I
-
S
V
R
H
N
P
E
F
T
M
M
E
L
Y
M
-
A
Y
A
D
Y
K
D
L
I
E
L
T
E
S
L
F
R
T
L
A
Q
D
I
----------------------
L
G
-----------
K
T
EVTYGD
V
T
L
D
FG
K
---------------
P
F
E
K
-------------------
L
T
M
R
E
-
A
I
K
K
Y
R
P
E
T
D
M
A
D
L
D
---------------
N
-----
F
-------
D
S
A
K
A
I
A
E
S
I
G
----
I
--------
H
--
V
--
E
K
S
W
G
L
G
R
--
I
V
T
E
I
F
E
E
V
A
E
A
H
L
--
I
Q
P
T
F
I
T
E
Y
P
A
E
V
S
P
L
A
--
R
R
N
D
V
N
P
E
I
T
D
R
F
E
F
F
I
G
G
R
E
I
G
N
G
F
S
E
L
N
D
A
E
D
Q
A
Q
R
F
L
D
Q
V
A
A
K
D
A
G
D
D
E
A
M
F
Y
D
E
D
Y
V
T
A
L
E
-
H
G
L
P
P
T
A
G
L
G
I
G
I
D
R
M
V
M
L
F
T
N
S
H
T
I
R
D
V
I
L
F
P
A
---
37
HHSearch
67.33
28%
5
- C8 -
-
5ELN
4
?
D:
[177-520]
----------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Y
L
D
L
M
L
N
E
E
S
R
K
V
F
K
L
R
S
R
A
I
K
Y
I
R
N
Y
F
D
R
L
G
F
L
E
V
E
T
P
M
L
N
M
-
I
Y
-
G
G
A
A
A
R
P
F
I
T
Y
H
N
---
E
L
-
E
-
T
--
Q
L
--
Y
M
R
I
A
P
E
L
Y
L
K
Q
L
I
V
G
G
L
D
K
V
Y
E
I
G
K
N
F
R
N
E
G
I
-
D
L
T
H
N
P
E
F
T
A
M
E
F
Y
M
-
A
Y
A
D
Y
Y
D
L
M
D
L
T
E
E
L
I
S
G
L
V
L
E
I
HGSLKIPYHPDGPEGKCIEIDF
T
T
-----------
P
W
------------
K
---------------
R
F
----------------------
S
F
V
E
-
E
---
I
E
S
G
L
G
E
K
L
K
R
P
--------------
L
DSQEN
I
-------
D
F
M
V
E
M
C
E
K
H
E
----
I
--------
E
--
L
--
P
H
P
R
T
A
A
K
--
L
L
D
K
L
A
G
H
F
V
E
T
K
C
T
--
N
P
S
F
I
I
D
H
P
Q
T
M
S
P
L
A
K
W
H
--
R
E
K
P
E
M
T
E
R
F
E
L
F
V
L
G
K
E
L
C
N
A
Y
T
E
L
N
E
P
L
Q
Q
R
K
F
F
E
Q
Q
A
D
A
K
A
S
G
D
V
E
A
C
P
I
D
E
T
F
C
L
A
L
E
H
G
-
L
P
P
T
G
G
W
G
L
G
I
D
R
L
I
M
F
L
A
D
K
N
N
I
K
E
V
I
L
F
P
A
M
R
-
19
PsiBlast_PDB
66.95
27%
-17
- C8 -
-
4PG3
2
?
A:
[177-502]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
T
K
I
I
N
F
L
R
N
F
L
N
E
R
G
F
F
E
V
E
T
P
M
M
N
L
I
A
G
G
A
N
A
R
----
P
F
I
T
H
---
H
N
D
L
D
L
--
D
L
--
Y
L
R
I
A
T
E
L
P
L
K
M
L
I
V
G
G
I
D
K
V
Y
E
I
G
K
V
F
R
N
E
G
I
-
D
N
T
H
N
P
E
F
T
S
C
E
F
Y
W
-
A
Y
A
D
Y
N
D
L
I
K
W
S
E
D
F
F
S
Q
L
V
Y
H
L
----------------------
F
G
TY
K
I
S
Y
NKDGP
E
N
------------
Q
---------------
P
I
-
E
-------------------
I
D
F
T
P
-
P
---
Y
P
K
V
S
I
V
E
E
I
E
K
V
T
NTILEQPFDS
N
E
T
-----
I
-------
E
K
M
I
N
I
I
K
E
H
K
----
I
--------
E
--
L
--
P
N
P
P
T
A
A
K
--
L
L
D
Q
L
A
S
H
F
I
E
N
K
Y
N
-
D
K
P
F
F
I
V
E
H
P
Q
I
M
S
P
L
A
K
Y
H
R
T
K
P
G
--
L
T
E
R
L
E
M
F
I
C
G
K
E
V
L
N
A
Y
T
E
L
N
D
P
F
K
Q
K
E
C
F
----------------
L
D
S
A
F
C
T
S
L
E
-
Y
G
L
P
P
T
G
G
L
G
L
G
I
D
R
I
T
M
F
L
T
N
K
N
S
I
K
D
V
I
L
F
P
T
---
36
HHSearch
66.34
28%
6
- C8 -
-
5ELO
2
?
A:
[177-520]
----------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Y
L
D
L
M
L
N
E
E
S
R
K
V
F
K
L
R
S
R
A
I
K
Y
I
R
N
Y
F
D
R
L
G
F
L
E
V
E
T
P
M
L
N
M
-
I
Y
-
G
G
A
A
A
R
P
F
I
T
Y
H
N
---
E
L
-
E
-
T
--
Q
L
--
Y
M
R
I
A
P
E
L
Y
L
K
Q
L
I
V
G
G
L
D
K
V
Y
E
I
G
K
N
F
R
N
E
G
I
-
D
L
T
H
N
P
E
F
T
A
M
E
F
Y
M
-
A
Y
A
D
Y
Y
D
L
M
D
L
T
E
E
L
I
S
G
L
V
L
E
I
HGSL
K
I
P
Y
H
PDGPE
G
K
C
I
E
I
D
F
T
T
-----------
P
W
------------
K
---------------
R
F
----------------------
S
F
V
E
-
E
---
I
E
S
G
L
G
E
K
L
K
R
P
--------------
L
DS
Q
E
N
I
-------
D
F
M
V
E
M
C
E
K
H
E
----
I
--------
E
--
L
--
P
H
P
R
T
A
A
K
--
L
L
D
K
L
A
G
H
F
V
E
T
K
C
T
--
N
P
S
F
I
I
D
H
P
Q
T
M
S
P
L
A
K
W
H
--
R
E
K
P
E
M
T
E
R
F
E
L
F
V
L
G
K
E
L
C
N
A
Y
T
E
L
N
E
P
L
Q
Q
R
K
F
F
E
Q
Q
A
D
A
K
A
S
G
D
V
E
A
C
P
I
D
E
T
F
C
L
A
L
E
H
G
-
L
P
P
T
G
G
W
G
L
G
I
D
R
L
I
M
F
L
A
D
K
N
N
I
K
E
V
I
L
F
P
A
M
R
-
41
HHSearch
65.77
27%
8
- C8 -
-
4DPG
2
SYK_HUMAN
B:
[161-506]
----------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
Y
L
D
L
I
L
N
D
F
V
R
Q
K
F
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
L
G
F
L
E
I
E
T
P
M
M
N
I
-
I
P
-
G
G
A
V
A
K
P
F
I
T
Y
H
N
---
E
L
-
D
-
M
--
N
L
--
Y
M
R
I
A
P
E
L
Y
H
K
M
L
V
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
N
E
G
I
-
D
L
T
H
N
P
E
F
T
T
C
E
F
Y
M
-
A
Y
A
D
Y
H
D
L
M
E
I
T
E
K
M
V
S
G
M
V
K
H
I
TGSY
K
V
T
Y
H
PDGPE
G
Q
A
Y
D
V
D
F
T
P
-----------
P
F
------------
R
---------------
R
I
----------------------
N
M
V
E
-
E
---
L
E
K
A
L
G
M
K
L
P
E
T
--------------
N
-----
L
FET
E
E
T
R
K
I
L
D
D
I
C
V
A
K
A
----
V
--------
E
--
C
--
P
P
P
R
T
T
A
R
--
L
L
D
K
L
V
G
E
F
L
E
V
T
C
I
--
N
P
T
F
I
C
D
H
P
Q
I
M
S
P
L
A
K
W
H
--
R
S
K
E
G
L
T
E
R
F
E
L
F
V
M
K
K
E
I
C
N
A
Y
T
E
L
N
D
P
M
R
Q
R
Q
L
F
E
E
Q
A
K
A
K
A
A
G
D
D
E
A
M
F
I
D
E
N
F
C
T
A
L
E
Y
G
-
L
P
P
T
A
G
W
G
M
G
I
D
R
V
A
M
F
L
T
D
S
N
N
I
K
E
V
L
L
F
P
A
M
K
-
50
HHSearch
65.75
28%
20
- C8 -
-
4UP7
1
?
A:
[166-568]
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
L
D
L
I
V
N
P
E
S
V
K
N
F
V
L
R
T
K
V
V
K
A
V
R
K
Y
L
D
D
K
G
F
L
E
V
E
T
P
I
L
N
T
-
I
P
-
G
G
A
T
A
R
P
F
I
T
H
H
N
---
Q
L
-
D
-
I
--
Q
M
--
Y
M
R
I
A
P
E
L
Y
L
K
E
L
V
V
G
G
I
N
R
V
Y
E
I
G
R
L
F
R
N
E
G
I
-
D
Q
T
H
N
P
E
F
T
T
C
E
F
Y
M
-
A
Y
A
D
Y
N
D
I
M
K
M
T
E
E
L
L
G
N
M
V
K
D
I
TGGS
T
K
L
E
I
KFV
T
E
K
K
M
V
L
D
F-
T
A
-----------
P
F
------------
K
---------------
R
I
----------------------
S
Y
V
H
-
A
---
L
E
E
K
F
G
E
K
I
P
R
P
L-------------
D
-----
G
-------
P
E
A
L
T
F
L
K
K
Q
A
I
R
F
N
A
--------
I
--
C
--
A
E
P
Q
T
T
A
R
--
V
M
D
K
L
F
G
D
L
I
E
V
D
L
V
--
Q
P
T
F
V
C
D
Q
P
Q
L
M
S
P
L
A
K
Y
H
--
R
S
E
P
E
L
T
E
R
F
E
L
F
I
L
K
R
E
I
A
N
A
Y
T
E
L
N
N
P
I
V
Q
R
S
N
F
E
Q
Q
A
K
D
K
A
A
G
D
D
E
A
Q
L
V
D
E
V
F
L
D
A
I
E
H
A
-
F
P
P
T
G
G
W
G
L
G
I
D
R
L
A
M
L
L
A
D
V
D
N
I
K
E
V
I
L
F
P
T
M
R
-