@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VT65: (2017-12-11 )
MSDWPPKPQNEPITPKQNGPEWQILEKAVLASVEEQRRSRRWGIFFKTLTFIYLLFIIVLMGKGCSTTKDGSTASSSSAHLAVVDIIGTIDASSNQAVNSEDTNKALKRAFEASNSKAIALNINSPGGSPVQSDEIWQEIRYLKKEHPDKKVYAVIGDMGASGAYYIASAADEIIVNPSSLVGSIGVIMPNYGITGLAQKLGIEDRTLTAGTNKDILSMTKPINPVQRQHIQSVLDNVHTHFINAVKEGRGKRLKTNDPAIFSGLFWTGEQAIQLGVADRSGNITSLMRELKLDNKVDYTIERNPLQSILGRMGSEMGKGLSESVAERLQTSQDAKLQ
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------.........10---....-----....20........30.....-------...40...-.....50........60----------...--------.....70........80-----------------------------.........90--....--.....100.......110.......---------------120...-....----------130......-.140-----........150....--..---.160.......170-.--.--......180..----...--------------..190--........----200.......210--.......220-....--------....230.......240.....---..250....----...260-.-.-..--------...270.......280-.......290---.----..--....--------.300------------.........310.......320.......330......------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------MSDWPPKPQNE---PITP-----KQNGP
E
W
Q
I
L
E
K
A
V
L
A
S
V
E
E
Q
-------
R
R
SRRW
G
I
-
F
F
K
T
L
T
F
I
Y
L
L
F
I
I
V
L
M----------GKG--------CSTTKDGSTASSSS
A
H
------------------------------
L
A
V
V
D
I
I
G
TI---DASS--NQAVN
S
E
D
T
N
K
A
L
K
R
A
F
EASNS
K
A
I
---------------
A
L
N
INS-PGGS----------PV
Q
S
D
E
I
W
Q
-
E
I
R
------
Y
L
K
K
EHPDK
K
V
Y
A
V
I--GD---MGASG
A
Y
Y
I
ASAA--
D
--
E
--
I
I
V
N
P
S
S
L
VGS----
I
G
V
--------------IMPN---Y
G
I
T
G
L
A
Q
----
K
LGIED
R
T
LTAGT--NK
D
I
L
S
MTK--PI
N
P
--------
V
Q
R
Q
H
I
Q
S
V
L
D
N
V
H
T
H
F
I
N
A
V
K
---EGRGKRLKT----NDP
A
I
F
-
S
-
G
-
L
F--------WTGE
Q
A
I
Q
L
GVADRSG-
N
I
T
S
L
M
R
E
L----K----LD--NKV
D
--------
Y
T
--------------
I
ER
N
P
L
Q
S
I
L
G
R
M
G
S
E
M
G
K
G
L
S
E
S
V
A
E
R
L
QTSQDAKLQ------------
1
PsiBlast_PDB
99.43
35%
0
- C- -
-
4KWB
-
SPPA_BACSU
A:
[56-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
S
K
------------------------------
I
A
V
L
E
V
S
G
T
I
QDN-------
D
G
Y
N
H
R
T
F
L
K
N
L
E
R
A
K
D
D
K
T
V
K
G
I
---------------
V
L
K
V
N
S
-
P
G
G
G
----------
V
Y
E
S
A
E
I
H
K
-
K
L
E
------
E
I
K
K
E
-
T
K
K
P
I
Y
V
S
M
--
G
S
---
M
A
A
S
G
G
Y
Y
I
S
T
A
A
--
D
--
K
--
I
F
A
T
P
E
T
L
T
G
S
----
L
G
V
--------------
I
M
E
S
---
V
N
Y
S
K
L
A
D
----
K
L
G
I
S
F
E
T
I
K
S
G
A
--
H
A
D
I
M
S
P
S
R
--
E
M
T
K
--------
E
E
K
N
I
M
Q
S
M
V
D
N
S
Y
E
G
F
V
D
V
I
S
---
K
G
R
G
M
P
-
K
A
----
E
V
K
K
I
A
-
D
-
G
-
R
V
--------
Y
D
G
R
Q
A
K
K
L
N
L
V
D
E
L
G
-
F
Y
D
D
T
I
T
A
M
----
K
----
K
D
--
H
K
----------------------------------------------------------------------------
2
PsiBlast_PDB
87.05
35%
-
* C4 *
-
3RST
-
SPPA_BACSU
A:
[57-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
K
------------------------------
I
A
V
L
E
V
S
G
T
I
QDN-------
D
G
Y
N
H
R
T
F
L
K
N
L
E
R
A
K
D
D
K
T
V
K
G
I
---------------
V
L
K
V
N
S
-
P
G
G
G
----------
V
Y
E
S
A
E
I
H
K
-
K
L
E
------
E
I
K
K
E
-
T
K
K
P
I
Y
V
S
M
--
G
S
---
M
A
A
S
G
G
Y
Y
I
S
T
A
A
--
D
--
K
--
I
F
A
T
P
E
T
L
T
G
S
----
L
G
V
--------------
I
M
E
S
---
V
N
Y
S
K
L
A
D
----
K
L
G
I
S
F
E
T
I
K
S
G
A
--
H
A
D
I
M
S
P
S
R
--
E
M
T
K
--------
E
E
K
N
I
M
Q
S
M
V
D
N
S
Y
E
G
F
V
D
V
I
S
---
K
G
R
G
-
M
P
K
A
----
E
V
K
K
I
A
-
D
-
G
-
R
V
--------
Y
D
G
R
Q
A
K
K
L
N
L
V
D
E
L
G
-
F
Y
D
D
T
I
T
A
M
----
K
----
K
D
--
H
K
----------------------------------------------------------------------------
50
HHSearch
84.73
35%
-
- C4 -
-
3RST
-
SPPA_BACSU
C:
[57-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
K
------------------------------
I
A
V
L
E
V
S
G
T
I
---
Q
D
-----
D
G
Y
N
H
R
T
F
L
K
N
L
E
R
A
K
D
D
K
T
V
K
G
I
---------------
V
L
K
V
N
S
-
P
G
G
G
----------
V
Y
E
S
A
E
I
H
K
-
K
L
E
------
E
I
K
K
E
T
-
K
K
P
I
Y
V
S
M
--
G
S
---
M
A
A
S
G
G
Y
Y
I
S
T
A
A
--
D
--
K
--
I
F
A
T
P
E
T
L
T
G
S
----
L
G
V
--------------
I
M
E
S
---
V
N
Y
S
K
L
A
D
----
K
L
G
I
S
F
E
T
I
K
S
G
A
--
H
A
D
I
M
S
P
S
R
--
E
M
T
K
--------
E
E
K
N
I
M
Q
S
M
V
D
N
S
Y
E
G
F
V
D
V
I
S
---
K
G
R
G
M
P
K
A
E
----
V
-
K
K
I
A
-
D
-
G
-
R
V
--------
Y
D
G
R
Q
A
K
K
L
N
L
V
D
E
L
G
-
F
Y
D
D
T
I
T
A
M
-------------------------------------------------------------------------------------------
49
HHSearch
84.53
35%
-
- C4 -
-
3RST
-
SPPA_BACSU
B:
[57-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
K
------------------------------
I
A
V
L
E
V
S
G
T
I
---
Q
D
N
------
Y
N
H
R
T
F
L
K
N
L
E
R
A
K
D
D
K
T
V
K
G
I
---------------
V
L
K
V
N
S
-
P
G
G
G
----------
V
Y
E
S
A
E
I
H
K
-
K
L
E
------
E
I
K
K
E
T
-
K
K
P
I
Y
V
S
M
--
G
S
---
M
A
A
S
G
G
Y
Y
I
S
T
A
A
--
D
--
K
--
I
F
A
T
P
E
T
L
T
G
S
----
L
G
V
--------------
I
M
E
S
---
V
N
Y
S
K
L
A
D
----
K
L
G
I
S
F
E
T
I
K
S
G
A
--
H
A
D
I
M
S
P
S
R
--
E
M
T
K
--------
E
E
K
N
I
M
Q
S
M
V
D
N
S
Y
E
G
F
V
D
V
I
S
---
K
G
R
G
M
P
K
A
E
----
V
-
K
K
I
A
-
D
-
G
-
R
V
--------
Y
D
G
R
Q
A
K
K
L
N
L
V
D
E
L
G
-
F
Y
D
D
T
I
T
A
M
-------------------------------------------------------------------------------------------
69
Fugue
67.04
22%
28
- C4 -
-
3BF0
-
SPPA_ECOLI
A:
[56-549]
R
G
A
L
L
LDI
S
G
V
I
V
DKPLQENS
L
F
D
I
V
N
T
I
R
Q
A
K
D
DRNIT
G
I
V
M
DLKNFAGGD
Q
P
S
M
Q
Y
I
G
K
A
L
K
E
F
R
D
S
G
K
P
V
Y
A
V
G
ENYS
Q
G
Q
Y
Y
L
A
S
F
AN
K
I
W
L
S
PQGVV
D
L
H
G
F
A
T
N
G
L
Y
Y
K
S
L
L
D
K
L
K
V
S
T
H
V
F
R
V
G
TYKSAVEPFIRDDMS
P
A
A
R
E
A
D
S
R
W
I
G
E
L
W
Q
N
Y
L
N
---
T
V
A
A
-----
N
R
Q
I
P
A
E
Q
V
F
P
G
A
Q
G
L
L
E
G
L
T
K
T
G
GD
T
A
K
Y
A
L
E
N
K
L
-
V
D
A
L
A
S
S
A
E
I
E
K
A
L
T
K
E
FGWSKTDKN
Y
R
A
I
--------
S
Y
Y
D
Y
A
L
K
T
P
A
D
T
G
D
S
------------------------------
I
G
V
V
F
A
N
G
A
I
MD-
G
E
E
T
--
Q
G
N
V
G
G
D
T
T
A
A
Q
I
R
D
A
R
L
D
P
K
V
K
A
I
---------------
V
L
R
V
N
S
-
P
G
G
S
----------
V
T
A
S
E
V
I
R
A
-
E
L
A
------
A
A
R
A
--
A
G
K
P
V
V
V
S
M
--
G
G
---
M
A
A
S
G
G
Y
W
I
S
T
P
A
--
N
--
Y
--
I
V
A
N
P
S
T
L
T
G
S
----
I
G
I
--------------
F
G
V
I
---
T
T
V
E
N
S
L
D
----
S
I
G
V
H
T
D
G
V
S
T
S
P
--
L
A
D
-
V
S
I
T
R
--
A
L
P
P
--------
E
A
Q
L
M
M
Q
L
S
I
E
N
G
Y
K
R
F
I
T
L
V
A
---
D
A
R
H
S
T
P
E
Q
----
I
D
K
-
I
A
-
Q
-
G
-
H
V
--------
W
T
G
Q
D
A
K
A
N
G
L
V
D
S
L
G
-
D
F
D
D
A
V
A
K
A
----
A
----
E
L
--
A
K
V
K
--------
Q
W
--------------
H
L
E
Y
----------------------------------------------
48
HHSearch
62.62
26%
13
- C4 -
-
3BF0
-
SPPA_ECOLI
B:
[323-549]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
G
D
S
------------------------------
I
G
V
V
F
A
N
G
A
I
---
M
D
G
E
ET
Q
G
N
V
G
G
D
T
T
A
A
Q
I
R
D
A
R
L
D
P
K
V
K
A
I
---------------
V
L
R
V
N
S
-
P
G
G
S
----------
V
T
A
S
E
V
I
R
A
-
E
L
A
------
A
A
R
A
A
--
G
K
P
V
V
V
S
M
--
G
G
---
M
A
A
S
G
G
Y
W
I
S
T
P
A
--
N
--
Y
--
I
V
A
N
P
S
T
L
T
G
S
----
I
G
I
--------------
F
G
V
I
---
T
T
V
E
N
S
L
D
----
S
I
G
V
H
T
D
G
V
S
T
S
P
--
L
A
D
V
-
S
I
T
R
--
A
L
P
P
--------
E
A
Q
L
M
M
Q
L
S
I
E
N
G
Y
K
R
F
I
T
L
V
A
---
D
A
R
H
S
T
P
E
Q
----
I
-
D
K
I
A
-
Q
-
G
-
H
V
--------
W
T
G
Q
D
A
K
A
N
G
L
V
D
S
L
G
-
D
F
D
D
A
V
A
K
A
----
A
E
L
AK
V
K
Q
W
H
L
E
Y
--------------------------------------------------------------------------
3
PsiBlast_PDB
61.25
30%
-91
- C4 -
-
3BF0
-
SPPA_ECOLI
A:
[366-529]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
---------------
V
L
R
V
N
S
-
P
G
G
S
----------
V
T
A
S
E
V
I
---
R
A
E
------
L
A
A
A
R
A
A
G
K
P
V
V
V
S
M
--
G
G
---
M
A
A
S
G
G
Y
W
I
S
T
P
A
--
N
--
Y
--
I
V
A
N
P
S
T
L
T
G
S
----
I
G
I
--------------
F
G
V
I
---
T
T
V
E
N
S
L
D
----
S
I
G
V
H
T
D
G
V
S
T
S
P
--
L
A
D
V
-
S
I
T
R
--
A
L
P
P
--------
E
A
Q
L
M
M
Q
L
S
I
E
N
G
Y
K
R
F
I
T
L
V
A
---
D
A
R
H
S
T
P
E
Q
----
I
D
-
K
I
A
-
Q
-
G
-
H
V
--------
W
T
G
Q
D
A
K
A
N
G
L
V
D
S
L
G
-
D
F
--------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
60.73
30%
-86
- C4 -
-
3BEZ
-
SPPA_ECOLI
A:
[366-529]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
I
---------------
V
L
R
V
N
S
-
P
G
G
S
----------
V
T
A
S
E
V
I
---
R
A
E
------
L
A
A
A
R
A
A
G
K
P
V
V
V
S
M
--
G
G
---
M
A
A
S
G
G
Y
W
I
S
T
P
A
--
N
--
Y
--
I
V
A
N
P
S
T
L
T
G
S
----
I
G
I
--------------
F
G
V
I
---
T
T
V
E
N
S
L
D
----
S
I
G
V
H
T
D
G
V
S
T
S
P
--
L
A
D
V
-
S
I
T
R
--
A
L
P
P
--------
E
A
Q
L
M
M
Q
L
S
I
E
N
G
Y
K
R
F
I
T
L
V
A
---
D
A
R
H
S
T
P
E
Q
----
I
D
-
K
I
A
-
Q
-
G
-
H
V
--------
W
T
G
Q
D
A
K
A
N
G
L
V
D
S
L
G
-
D
F
--------------------------------------------------------------------------------------------------
54
HHSearch
54.99
21%
-81
- C4 -
-
3WG5
2
STOPP_PYRHO
B:
[6-181]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
N
I
------------------------------
V
Y
V
A
Q
I
K
G
Q
I
---
T
S
Y
T
-------
Y
D
Q
F
D
R
Y
I
T
I
A
E
-
Q
D
N
A
E
A
I
---------------
I
I
E
L
D
T
-
P
G
G
R
----------
A
D
A
M
M
N
I
V
Q
-
R
I
Q
------
Q
S
-----
K
I
P
V
I
I
Y
V
--
Y
P
PGA
S
A
A
S
A
G
T
Y
I
A
L
G
S
--
H
--
L
--
I
A
M
A
P
G
T
S
I
G
A
----
C
R
P
--------------
I
L
G
Y
---
S
Q
N
G
S
I
-----------------------------------------------
I
E
A
P
P
A
I
T
N
Y
F
I
A
Y
I
K
S
L
A
---
Q
E
S
G
R
N
A
T
I
----
A
E
E
F
I
T
-
K
-
D
-
L
S
--------
L
T
P
E
E
A
L
K
Y
G
V
I
E
V
V
A
R
D
I
N
E
L
L
K
K
--------------------------------------------------------------------------------------------
53
HHSearch
53.05
21%
-83
- C4 -
-
3VIV
2
STOPP_PYRHO
B:
[6-181]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
N
I
------------------------------
V
Y
V
A
Q
I
K
G
Q
I
---
T
S
Y
T
-------
Y
D
Q
F
D
R
Y
I
T
I
A
E
-
Q
D
N
A
E
A
I
---------------
I
I
E
L
D
T
-
P
G
G
R
----------
A
D
A
M
M
N
I
V
Q
-
R
I
Q
------
Q
S
-----
K
I
P
V
I
I
Y
V
--
Y
P
PGA
S
A
A
S
A
G
T
Y
I
A
L
G
S
--
H
--
L
--
I
A
M
A
P
G
T
S
I
G
A
----
C
R
P
--------------
I
L
G
Y
---
S
Q
N
G
S
I
-----------------------------------------------
I
E
A
P
P
A
I
T
N
Y
F
I
A
Y
I
K
S
L
A
---
Q
E
S
G
R
N
A
T
I
----
A
E
E
F
I
T
-
K
-
D
-
L
S
--------
L
T
P
E
E
A
L
K
Y
G
V
I
E
V
V
A
R
D
I
N
E
L
L
K
K
--------------------------------------------------------------------------------------------
51
HHSearch
51.71
21%
-12
- C4 -
-
3BF0
-
SPPA_ECOLI
B:
[56-294]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
G
------------------------------
A
L
L
L
D
I
S
G
V
I
---
V
D
K
P
--
D
Q
E
N
S
L
F
D
I
V
N
T
I
R
Q
A
K
D
D
R
N
I
T
G
I
---------------
V
M
D
L
K
N
F
A
G
G
D
----------
Q
P
S
M
Q
Y
I
G
K
-
A
L
K
------
E
F
R
D
S
--
G
K
P
V
Y
A
V
G
--
E
N
----
Y
S
Q
G
Q
Y
Y
L
A
S
F
A
--
N
--
K
--
I
W
L
S
P
Q
G
V
V
D
L
----
H
G
F
--------------
A
T
N
G
---
L
Y
Y
K
S
L
L
D
----
K
L
K
V
S
T
H
V
F
R
V
G
T
--
Y
K
S
A
V
E
P
F
I
RD
D
M
S
P
--------
A
A
R
E
A
D
S
R
W
I
G
E
L
W
Q
N
Y
L
N
T
V
A
---
A
N
R
Q
I
P
A
E
Q
----
V
-
F
P
G
A
-
Q
-
G
-
L
L
E
G
L
T
K
T
G
G
D
T
A
K
Y
A
L
E
N
K
L
V
D
A
L
A
-
S
S
A
E
I
E
K
A
--------------------------------------------------------------------------------------------
70
Fugue
45.49
18%
-84
- C4 -
-
1TYF
-
CLPP_ECOLI
A:
[11-193]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
G
E
R
S
F
D
I
Y
S
R
L
L
K
------------------------------
E
R
V
I
F
L
T
G
Q
V
---
E
-------
D
H
M
A
N
L
I
V
A
Q
M
L
F
L
E
A
E
N
P
E
K
D
I
---------------
Y
L
Y
I
N
S
-
P
G
G
V
----------
I
T
A
G
M
S
I
Y
D
-
T
M
Q
------
F
I
K
P
D
-----
V
S
T
I
C
--
M
G
---
Q
A
A
S
M
G
A
F
L
L
T
A
G
--
A
--
K
GK
R
F
C
L
P
N
S
---
R
----
V
M
I
--------------
H
Q
P
L
---
G
G
Y
Q
G
Q
A
T
----
D
I
E
I
H
A
R
E
I
L
K
V
K
--
G
R
M
N
E
L
M
A
L
--
H
T
G
Q
S
L
E
Q
I
E
R
D
T
E
R
D
R
F
L
S
A
P
E
A
V
E
Y
G
L
V
D
S
I
L
---
T
H
R
N
---------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
45.40
17%
-62
- C4 -
-
1Y7O
-
CLPP_STRR6
B:
[46-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
M
L
T
G
P
V
---
E
D
N
M
-------
A
N
S
V
I
A
Q
L
L
F
L
D
A
Q
D
S
T
K
D
I
---------------
Y
L
Y
V
N
T
-
P
G
G
S
----------
V
S
A
G
L
A
I
V
D
-
T
M
N
------
F
I
-----
K
A
D
V
Q
T
I
V
--
M
G
---
M
A
A
S
M
G
T
V
I
A
S
S
G
--
A
KG
K
--
R
F
M
L
P
N
A
E
Y
M
I
----
H
Q
P
--------------
M
------------------------------------------------------------
I
A
P
E
H
L
L
K
T
R
N
T
L
E
K
I
L
A
---
E
N
S
G
Q
S
M
E
K
----
V
-
H
A
D
A
-
E
-
R
D
N
W
--------
M
S
A
Q
E
T
L
E
Y
G
F
I
D
E
I
M
-
A
N
N
S
------------------------------------------------------------------------------------------------
60
HHSearch
45.29
17%
-59
- C4 -
-
1Y7O
-
CLPP_STRR6
G:
[46-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
I
M
L
T
G
P
V
---
E
D
N
M
-------
A
N
S
V
I
A
Q
L
L
F
L
D
A
Q
D
S
T
K
D
I
---------------
Y
L
Y
V
N
T
-
P
G
G
S
----------
V
S
A
G
L
A
I
V
D
-
T
M
N
------
F
I
-----
K
A
D
V
Q
T
I
V
--
M
G
---
M
A
A
S
M
G
T
V
I
A
S
S
G
--
A
KG
K
--
R
F
M
L
P
N
A
E
Y
M
I
----
H
Q
P
--------------
M
------------------------------------------------------------
I
A
P
E
H
L
L
K
T
R
N
T
L
E
K
I
L
A
---
E
N
S
G
Q
S
M
E
K
----
V
-
H
A
D
A
-
E
-
R
D
N
W
--------
M
S
A
Q
E
T
L
E
Y
G
F
I
D
E
I
M
-
A
N
N
S
------------------------------------------------------------------------------------------------
55
HHSearch
44.27
16%
-62
- C4 -
-
5G1S
-
CLPP_FRATT
Q:
[30-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
I
V
F
L
N
G
E
V
---
N
D
H
S
-------
A
N
L
V
I
A
Q
L
L
F
L
E
S
E
D
P
D
K
D
I
---------------
Y
F
Y
I
N
S
-
P
G
G
M
----------
V
T
A
G
M
G
V
Y
D
-
T
M
Q
------
F
I
-----
K
P
D
V
S
T
I
C
--
I
G
---
L
A
A
S
M
G
S
L
L
L
A
G
G
--
A
KG
K
--
R
Y
S
L
P
S
S
Q
I
M
I
----
H
Q
P
--------------
L
G
G
F
---
R
----------------------
G
Q
----------------
A
--------
S
D
I
E
I
H
A
K
N
I
L
R
I
K
D
R
L
N
K
V
L
A
---
H
H
T
G
Q
D
L
E
T
----
I
-
V
K
D
T
-
D
R
D
-
N
F
--------
M
M
A
D
E
A
K
A
Y
G
L
I
D
H
V
I
-
E
S
R
E
A
-----------------------------------------------------------------------------------------------
62
HHSearch
43.03
16%
-
- C4 -
-
4GM2
-
?
A:
[67-243]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
I
I
F
L
S
S
P
I
---
Y
P
H
I
-------
S
E
Q
I
I
S
Q
L
L
Y
L
E
Y
E
S
K
R
K
P
I
---------------
H
L
Y
I
N
S
-
T
G
D
I
DNNKIINLN
G
I
T
D
V
I
S
I
V
D
-
V
I
N
------
Y
I
-----
S
S
D
V
Y
T
Y
C
--
L
G
---
K
A
Y
G
I
A
C
I
L
A
S
S
G
--
K
KG
Y
--
R
F
S
L
K
N
S
S
F
C
L
----
N
Q
S
--------------
Y
S
I
I
---
P
---------------------
F
N
Q
----------------
A
--------
T
N
I
E
I
Q
N
K
E
I
M
N
T
K
K
K
V
I
E
I
I
S
---
K
N
T
E
K
D
T
N
V
----
I
-
S
N
V
L
E
R
-
D
-
K
Y
--------
F
N
A
D
E
A
V
D
F
K
L
I
D
H
I
L
-
E
K
--------------------------------------------------------------------------------------------------
58
HHSearch
42.63
18%
-
- C4 -
-
5E0S
-
CLPP2_MYCTU
e:
[38-209]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------
E
R
I
I
F
L
G
V
Q
V
---
D
D
A
S
-------
A
N
D
I
M
A
Q
L
L
V
L
E
S
L
D
P
D
R
D
I
---------------
T
M
Y
I
N
S
-
P
G
G
G
----------
F
T
S
L
M
A
I
Y
D
-
T
M
Q
------
Y
V
-----
R
A
D
I
Q
T
V
C
--
L
G
---
Q
A
A
S
A
A
A
V
L
L
A
A
G
--
T
PG
K
--
R
M
A
L
P
N
A
R
V
L
I
----
H
Q
P
--------------
S
L
S
G
---
V
I
--------------------
Q
G
Q
----------------
F
--------
S
D
L
E
I
Q
A
A
E
I
E
R
M
R
T
L
M
E
T
T
L
A
---
R
H
T
G
K
D
A
G
V
----
I
-
R
K
D
T
D
R
-
D
-
K
I
--------
L
T
A
E
E
A
K
D
Y
G
I
I
D
T
V
L
-
E
Y
R
K
L
-----------------------------------------------------------------------------------------------
77
Fugue
42.51
21%
44
- C1 -
-
4EWV
2
GH312_ARATH
A:
[14-581]
---------------------------------------------------------------------------------------------------------------------------------------------N
E
T
F
E
K
Q
L
K
D
L
TSN
V
K
S
I
Q
D
N
L
L
E
E
---
I
I
T
P
D
K
E
L
F
K
K
N
V
S
Y
E
D
I
K
P
Y
L
D
R
V
V
N
G
E
S
-------
Q
K
M
M
P
W
N
N
K
Y
L
D
N
L
T
F
I
Y
D
L
R
M
Q
V
I
T
----------
K
H
V
KGVEM
M
F
L
F
T
K
Q
E
P
A
R
V
A
T
S
S
Y
F
K
S
D
Y
F
K
N
RPSNWYYSYTSP
D
E
V
I
L
CPN
N
T
E
S
L
Y
C
H
L
L
C
G
L
V
---
Q
R
G
S
--
I
F
A
S
V
M
V
R
A
I
E
V
L
K
N
S
W
E
E
L
C
S
N
I
R
S
GHLSNWVTD
L
G
C
Q
N
S
V
S
L
V
L
-
G
G
P
R
----------
P
E
L
A
D
T
I
E
E
-
I
C
N
QNSWKG
I
V
K
R
L
W
P
N
T
K
Y
I
E
T
V
VT
G
S
---
M
G
Q
Y
V
P
M
L
N
Y
Y
C
N
--
D
--
L
--
P
L
V
--
S
T
T
Y
G
S
SETT
F
G
I
NLDPLCKPED
V
S
Y
T
F
M
P
N
MSY
F
E
F
I
G
C
T
Y
AGLY
R
M
R
V
G
D
I
V
L
V
T
G
F
YN
N
A
P
Q
F
K
F
V
R
--
R
E
N
V
--------
V
L
S
I
D
S
D
K
T
N
E
E
D
L
F
K
A
V
S
Q
A
K
L
V
L
E
S
S
G
L
D
L
K
D
F
T
S
Y
A
D
T
S
T
F
-
P
-
G
-
H
Y
V
V
------
Y
L
E
V
D
T
K
Q
F
E
L
D
E
E
A
L
-
S
T
C
C
L
V
M
E
E
----
S
----
L
D
--
N
V
Y
K
--------
R
C
R
FKDGSIG
P
L
E
I
R
V
V
R
Q
G
T
F
D
S
L
M
D
F
F
I
S
Q
-
G
A
S
T
G
Q
Y
K
T
P
R
C
I
K
S
G
K
A
L
Q
V
L
E
T
C
VV
A
K
F
F
S
I
71
Fugue
42.49
21%
41
- C2 -
-
4QTZ
-
?
A:
[6-326]
----------------------------------------------------------------------------------------------------------------------------------------------LG
N
V
V
C
V
T
GASG
Y
I
A
S
W
L
V
R
L
L
L
H
R
GY
T
V
K
A
-----
T
V
R
D
P
N
---
D
P
K
K
V
D
H
L
V
K
L
D
-------
G
A
K
E
R
L
Q
L
-
F
K
A
N
L
L
E
E
G
A
F
D
S
V
V
Q
G
----------
C
H
G
--------
V
F
H
T
A
S
P
F
Y
H
D
V
K
D
P
Q
------------------------------
A
E
---
L
I
D
P
A
---
L
K
G
T
--
L
N
V
L
N
S
C
A
K
S
P
S
L
K
R
V
V
L
T
S
S
I
A
A
V
---------------
A
Y
N
-
G
K
-
P
R
T
P
----------
D
V
V
V
D
E
T
W
F
T
D
A
D
------
F
C
A
K
S
N
L
---
W
Y
V
V
S
--
K
T
---
L
A
E
E
A
A
W
K
F
V
K
E
N
N
I
D
--
M
--
V
T
I
N
P
A
M
V
I
G
P
----
L
-------------------------------------------
L
Q
P
V
L
--
N
T
S
A
A
A
I
L
N
--
L
I
N
G
--------------
A
Q
T
F
P
N
A
S
F
G
W
V
N
-
V
K
---
D
V
A
N
A
H
I
L
A
----
Y
E
N
A
S
A
-
S
-
G
--------------
R
H
C
L
V
E
R
V
A
H
Y
S
--
E
V
V
R
I
L
R
E
L
Y
P
S
L
Q
----
L
P
--
E
K
C
A
DDKPYV
P
I
Y
Q
--------------
V
S
K
E
K
A
K
S
-
L
G
L
E
Y
T
P
L
E
V
S
I
K
E
T
V
-
E
S
L
K
E
K
K
F
A
N
L
-------------
65
HHSearch
41.44
18%
-50
- C4 -
-
4RYF
-
?
A:
[18-188]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
I
D
------------------------------
T
R
T
V
L
I
Y
G
E
I
---
N
Q
E
L
-------
A
E
D
V
S
K
Q
L
L
L
L
E
S
I
S
-
N
D
P
I
---------------
T
I
F
I
N
S
-
Q
G
G
H
----------
V
E
A
G
D
T
I
H
D
-
M
I
K
------
F
I
-----
K
P
T
V
K
V
V
G
--
T
G
---
W
V
A
S
A
G
I
T
I
Y
L
A
A
--
E
--
K
EN
R
F
S
L
P
N
T
R
Y
M
I
----
H
Q
P
--------------
A
G
G
V
---
Q
G
Q
--------------------------------------
S
--------
T
E
I
E
I
E
A
K
E
I
I
R
M
R
E
R
I
N
R
L
I
A
---
E
A
T
G
Q
S
Y
E
Q
----
I
-
S
K
D
T
D
R
-
N
-
F
W
--------
L
S
V
N
E
A
K
D
Y
G
I
V
N
E
I
I
-
E
N
R
D
G
-----------------------------------------------------------------------------------------------