@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VT92: (2017-12-12 )
MFIVAGAAAHSSFKKAQLLTRLSSISSVQSFDSQWVYLFDQALNEQQHQSALQLLNDGESFELRQPASDEIQILVTPRVGTISPWSSKATDIFKNCNTPVHRLERGLLFTLKGVSEITNEVKQVLHDRMTETVFAQIEDAKALFSETAPKPLNSIDILGQGKEALVKANNEFGFALSEQEIDYLTEAFTRLGRNPNDIELMMFAQANSEHCRHKIFGSEWTIDGEKQPLSLFQMIKNTYKESPTDVLSAYKDNASVIVGYDTMRFYPKADENGHFVYKYKSQAAHILMKVETHNHPTAISPFAGAATGSGGEIRDEGATGRGGKPKAGLTGFTVSNLNIPGFEQPWEENYGKPSRMASPLQIMIEGPLGGAAFNNEFGRPALNGYFRTFEQNVNGEVKGFHKPIMIAGGYGNIRPDHVEKDAIQPGDLLIVLGGPAMLIGLGGGAASSVDSGTMGESLDFASVQRENPEMERRCQEVIDTCWRLEDFNPIVSIHDVGAGGLSNAMPELVNDHELGAVLNLRKIPSLEPGMSPMEIWSNEAQERYVLAIRPESLEQFESICARERCPFAVLGEATEARHLTVEDPLFQNNAVDIPMQVMLGGTPRMQCSYETIERKGNEFDASKVDLKDAIFRVLKNPTVASKSFLITIGDRSITGMVARDQMVGRWQIPVADAAVTTTSLQGFTGEAMAMGERPPVALLNPAASARLAVAEAITNIACANIEQISDIKLSANWMAAAGQKGEDQALFEGVKAIGMEMCPALGIAIPVGKDSLSMRTTWNDNGEDKAVTSPMTGVITAFAPVADVRKTLTPELKNLEDSVLVRIDLSKGQFRLGGSILAQVYKAIGSVTPDVDSFDDFKAFFALIQDWNNRGLIQAYHDIGDGGLLATVAEMMFASRLGVALEDQTTAGLFAEEIGAVVQIKAADWEALQAEVAASSLKDAIAVVGRVNNTDQLSVNGLTLERAELQQAWSEVSHQIQRLRDNVETADQEFALITDKSHQGLIAKPTFDLNEPIEAPFINSRRPNMAILREQGVNGHIEMAAAFDKVGFNTIDVHMSDLLAGRVSLSDFEGLVTCGGFSYGDVMGAGGGWAKSVLFNAKLRDQFEQFFHREGTFSLGICNGCQMLSQLAPLIPGAEHWPRFHRNMSEVFEARSVNVRVEKSVSVLLDGMEGSILPIAVAHGEGRAVASEADIASLNAANQVALRYVDSHGNPTQHYPLNPNGSPEAITGVTSKDGRATIMMPHPERTFRAIQHSWKPEEWTEDGAWLRMFRNARKFIG
Atome Classification :
(20 SA)
.........10........20.....-...30........40-.........50........60........70........80........90......-..100.......110.......120..---.....130.......140.......150.......160.......170.......180.......-190...-....200.......210.......220.......230.......240...--....--250.....-..260----.......270.......280.......290...-....--300.......310.......320.....-..330.......340.......350.......360.......370-.-......380..--.....390...----....400-.......410....-.-..420.......430.......440.......450.....-....460.------.-..----..--.470.......480.........490.......500.......510.......520......---------------------------.------530-----.....---.-------------.-..-540.......550.......560--.-.....-.570.....--..580.......590........600.......610.-.....--.620.......630.......640.......650.......660.......670...---....680.......690---....--...700.......710.......720......-.730......-.-740........750.......760.......770.......780.......790.......800.......810.......820.......830.....-..840..------..-..-..--850..--....---.860.......-870........880.......890.......-----900--.---------.------------.-------------.-.---..910-..-.....920.......930..--.--....940.......950.....--.-----..960.......970.......980.......990.......1000......1010......1020.......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180.-.....1190......1200......1210......1220......1230......1240......1250......1260......1270....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
F
I
VAGAAAHS
S
F
K
K
A
Q
L
L
T
R
L
S
S
I
S
-
S
V
Q
S
FD
S
Q
W
V
Y
L
F
D
--
Q
A
L
N
E
Q
Q
H
Q
S
A
L
Q
L
LNDGES
F
E
LRQPASD
E
I
Q
I
L
V
TPRVGTISPWS
S
K
A
T
D
I
F
K
NCN-T
P
V
H
R
L
ERG
L
L
F
T
L
K
G
V
S
E
I
T
N
E
V
K
Q
V
---
L
H
D
R
M
T
E
T
V
F
A
Q
I
E
D
A
K
A
L
F
S
ETAPKPLNS
I
D
ILGQG
K
E
A
L
V
KANNEFGFAL
S
E
Q
E
I
D
Y
L
T
E
A
F
T
-RLGRNP-ND
I
E
L
M
M
F
A
QAN
S
E
H
C
R
HKIFGSEWTIDGEKQ
P
L
S
L
F
Q
M
I
K
N
T
YKES
P
T
D
--
V
L
S
A
--YKDN
A
S
V
I
-
V
G
YDT----
M
R
FYPKADENG
H
F
V
Y
K
YKSQ
A
A
H
I
L
M
K
V
ETHNH-PTAI--SPFAGAATGSGGEIRDEGATGRGGKPKA-G
L
T
G
F
T
V
SNLNIPGFEQ
P
W
E
ENYG
K
P
S
RMAS
P
L
Q
I
M
I
EGPLGGAA-F-NNEFGR
P
A
L
N
G
--
Y
F
R
T
F
E
QNVNG----EVKGFHK-
P
I
M
I
AGGYGNI
R
P
D
-
H
-VEKDAIQPG
D
L
L
I
V
LGG
P
A
M
L
I
G
LGGGAASSVD--SGTMG-ESL
D
F
A
S
V------Q-RE----N
P
--
E
M
E
R
R
C
Q
E
V
I
D
T
--
C
WRLEDFNP
I
V
S
I
H
DVGAG
G
L
S
N
A
M
P
E
L
V
N
D
HE
L
G
A
V
L
NLRKIPSLEP---------------------------G------M-------
S
P
M
E
I
---
W
-------------S-NE-AQ
E
R
Y
V
L
A
IR
P
E
S
L
E
Q
F
E
S
I
C
A
R--E-RC
P
F
A
-VLGEATE
A
R
--
H
L
TVEDPLFQNNAV-DI
P
M
Q
VMLGGTP
R
M
Q
C
S
Y
E
T
I
E
-RKGNE--FDASKV
D
L
K
D
A
I
F
R
V
LKNPTVAS
K
S
F
L
I
T
IGDRSI
T
G
M
V
A
R
D
QMVGRWQIPVADA
A
V
---
T
T
T
SLQGFTG
E
A
MAMGE---RP
P
V
--
A
L
LNP
A
A
S
A
R
L
A
V
A
E
A
I
T
N
I
ACA
N
I
E
Q
I
S
D
I
K
-
L
SA
N
W
MAAAG-Q-KG-
E
D
Q
A
L
F
E
G
V
K
A
I
G
M
E
MCPAL
G
I
A
I
PVGKDS
L
S
M
R
TTWNDNGEDKAVTSP
M
T
G
V
I
T
AFA
P
V
A
D
V
R
K
TL
T
P
E
L
KNLED
S
V
L
V
R
I
DLSKG
Q
F
RL
G
G
S
I
L
-
A
Q
V
-
Y
K
A
------
I
G-SV-TP--DVD
S
F
--
D
D
F
K
---
A
F
F
A
L
I
Q
DWNN-R
G
-
L
I
Q
A
Y
H
DIGDG
G
L
L
A
T
V
A
E
M
M
F
A
S
RLG
V
-----
A
LE--D---------Q------------T-------------T-A---
G
L
F
A
E
-EI-
G
A
V
V
Q
I
KAA
D
W
E
A
L
Q
A
E
V
A
A
--
S
--
S
L
K
D
A
I
A
V
VGRVNNT
D
-
Q
L
S
VN--
G
-----
L
T
L
E
R
A
E
L
Q
Q
A
W
S
E
V
S
H
Q
I
Q
R
L
R
DNVETADQ
E
F
A
L
I
TDKSHQGLIAKPTFDLNEPIEAPFINS-RRP
N
M
A
I
L
R
EQGVNG
H
I
E
M
A
A
A
F
D
KVGF
N
T
I
D
V
H
M
S
D
L
L
AGRVSLSDFE
G
L
V
TCGGFSYGDVMGAGG
G
W
A
K
S
V
L
F
N
A
K
L
R
D
Q
F
E
Q
F
F
HREG
T
F
S
LGI
C
N
G
C
Q
M
L
S
Q
L
A
PLIPG
A
E
H
W
P
R
F
H
R
N
M
S
E
V
F
E
ARS
V
N
V
R
V
E
K
S
V
S
V
L
LDGMEG
S
I
L
P
I
A
V
AHGEGRA-VASEADIASLNAAN
Q
V
A
L
R
Y
VDSHGNPTQHYPLNPNGSPE
A
I
T
G
VTSKDG
R
A
T
I
MMPH
P
E
R
T
F
R
A
I
Q
HSWK
P
E
EWTED
G
A
W
L
R
M
F
R
N
A
R
K
FIG
1
PsiBlast_PDB
70.86
56%
23
- C4 -
-
3UGJ
1
PUR4_SALTY
A:
[10-1303]
M
E
I
L
R
G
S
P
A
L
S
A
F
R
I
N
K
L
L
A
R
F
Q
A
A
N
L
Q
V
H
N
I
Y
A
E
Y
V
H
F
A
D
L
N
A
P
L
N
D
S
E
Q
A
Q
L
T
R
L
L
Q
Y
G
P
A
L
S
S
H
T
P
A
G
K
--
L
L
L
V
T
P
R
P
G
T
I
S
P
W
S
S
K
A
T
D
I
A
H
N
C
G
L
Q
Q
V
D
R
L
E
R
G
V
A
Y
Y
I
E
A
S
T
L
T
A
E
Q
W
R
Q
V
A
A
E
L
H
D
R
M
M
E
T
V
F
S
S
L
T
D
A
E
K
L
F
I
H
H
Q
P
A
P
V
S
S
V
D
L
L
G
E
G
R
Q
A
L
I
D
A
N
L
R
L
G
L
A
L
A
E
D
E
I
D
Y
L
Q
E
A
F
T
-
K
L
G
R
N
P
-
N
D
I
E
L
Y
M
F
A
Q
A
N
S
E
H
C
R
H
K
I
F
N
A
D
W
I
I
D
G
K
P
Q
P
K
S
L
F
K
M
I
K
N
T
F
E
T
T
P
D
Y
--
V
L
S
A
--
Y
K
D
N
A
A
V
M
-
E
G
S
A
V
----
G
R
Y
F
--
A
D
H
N
T
G
-
R
Y
D
F
H
Q
E
P
A
H
I
L
M
K
V
E
T
H
N
H
-
P
T
A
I
--
S
P
W
P
G
A
A
T
G
S
G
G
E
I
R
D
E
G
A
T
G
R
G
A
K
P
K
A
-
G
L
V
G
F
S
V
S
N
L
R
I
P
G
F
E
Q
P
W
E
E
D
F
G
K
P
E
R
I
V
T
A
L
D
I
M
T
E
G
P
L
G
G
A
A
-
F
-
N
N
E
F
G
R
P
A
L
T
G
--
Y
F
R
T
Y
E
E
K
V
N
S
HN
G
E
E
L
R
G
Y
H
K
-
P
I
M
L
A
G
G
I
G
N
I
R
A
D
-
H
-
V
Q
K
G
E
I
V
V
G
A
K
L
I
V
L
G
G
P
A
M
N
I
G
L
--------------------
D
F
A
S
V
------
Q
-
R
D
----
N
P
--
E
M
E
R
R
C
Q
E
V
I
D
R
--
C
W
Q
L
G
D
A
N
P
I
L
F
I
H
D
V
G
A
G
G
L
S
N
A
M
P
E
L
V
S
D
G
G
R
G
G
K
F
E
L
R
D
I
L
S
D
E
P
---------------------------
G
------
M
-------
S
P
L
E
I
---
W
-------------
C
-
N
E
-
S
Q
E
R
Y
V
L
A
V
A
A
D
Q
L
P
L
F
D
E
L
C
K
R
--
E
-
R
A
P
Y
A
-
V
I
G
D
A
T
E
E
Q
--
H
L
S
L
H
D
N
H
F
D
N
Q
P
I
-
D
L
P
L
D
V
L
L
G
K
T
P
K
M
T
R
D
V
Q
T
L
K
-
A
K
G
D
A
--
L
N
R
A
D
I
T
I
A
D
A
V
K
R
V
L
H
L
P
T
V
A
E
K
T
F
L
V
T
I
G
D
R
T
V
T
G
M
V
A
R
D
Q
M
V
G
P
W
Q
V
P
V
A
D
C
A
V
---
T
T
A
S
L
D
S
Y
Y
G
E
A
M
S
I
G
E
---
R
A
P
V
--
A
L
L
D
F
A
A
S
A
R
L
A
V
G
E
A
L
T
N
I
A
A
T
Q
I
G
D
I
K
R
I
K
-
L
S
A
N
W
M
A
A
A
G
-
H
-
P
G
-
E
D
A
G
L
Y
D
A
V
K
A
V
G
E
E
L
C
P
Q
L
G
L
T
I
P
V
G
K
D
S
M
S
M
K
T
R
W
Q
E
G
--
Q
R
E
M
T
S
P
L
S
L
V
I
S
A
F
A
R
V
E
D
V
R
H
T
L
T
P
Q
L
S
T
-
E
D
N
A
L
L
L
I
D
L
G
K
G
H
N
A
L
G
A
T
A
L
-
A
Q
V
-
Y
R
Q
------
L
G
-
D
K
-
P
A
--
D
V
R
D
V
--
A
Q
L
K
---
G
F
Y
D
A
M
Q
A
L
V
A
-
A
R
-
K
L
L
A
W
H
D
R
S
D
G
G
L
L
V
T
L
A
E
M
A
F
A
G
H
C
G
V
Q
V
D
IA
A
L
G
--
D
---------
D
------------
H
-------------
L
-
A
---
A
L
F
N
E
-
E
L
-
G
G
V
I
Q
V
R
A
E
D
R
D
A
V
E
A
L
L
A
Q
--
Y
--
G
L
A
D
C
V
H
Y
L
G
Q
A
L
A
G
D
-
R
F
V
I
T
--
A
NDQTV
F
S
E
S
R
T
T
L
R
V
W
W
A
E
T
T
W
Q
M
Q
R
L
R
D
N
P
Q
C
A
D
Q
E
H
E
A
K
A
N
D
T
D
P
G
L
N
V
K
L
S
F
D
I
N
E
D
I
A
A
P
Y
I
A
T
G
A
R
P
K
V
A
V
L
R
E
Q
G
V
N
S
H
V
E
M
A
A
A
F
H
R
A
G
F
D
A
I
D
V
H
M
S
D
L
L
G
G
R
I
G
L
G
N
F
H
A
L
V
A
C
G
G
F
S
Y
G
D
V
L
G
A
G
E
G
W
A
K
S
I
L
F
N
H
R
V
R
D
E
F
E
T
F
F
H
R
P
Q
T
L
A
L
G
V
C
N
G
C
Q
M
M
S
N
L
R
E
L
I
P
G
S
E
L
W
P
R
F
V
R
N
H
S
D
R
F
E
A
R
F
S
L
V
E
V
T
Q
S
P
S
L
L
L
Q
G
M
V
G
S
Q
M
P
I
A
V
S
H
G
E
G
R
V
E
V
R
D
D
A
H
L
A
A
L
E
S
K
G
L
V
A
L
R
Y
V
D
N
F
G
K
V
T
E
T
Y
P
A
N
P
N
G
S
P
N
G
I
T
A
V
T
T
E
N
G
R
V
T
I
M
M
P
H
P
E
R
V
F
R
T
V
A
N
S
W
H
P
E
N
W
G
E
D
S
P
W
M
R
I
F
R
N
A
R
K
Q
L
G
14
HHSearch
48.35
24%
1
- C4 -
-
2HS3
1
PURL_THEMA
A:
[5-601]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
L
N
I
L
K
E
K
L
G
R
E
P
-
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
Y
S
H
T
K
K
Y
I
R
--------
R
---
L
-------------
P
K
T
G
--
F
E
G
N
A
G
V
V
-
N
L
D
-------------------------
D
Y
Y
S
V
A
F
K
I
E
S
H
N
H
-
P
S
A
I
--
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
V
L
A
M
--
G
A
R
P
T
A
-
I
F
D
S
L
H
M
S
R
I
-------------------------
I
D
G
I
I
E
G
I
A
D
-
Y
-
G
N
S
I
G
V
P
T
V
G
G
--
E
L
R
I
S
S
L
Y
A
-----------
H
N
-
P
L
V
N
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
--
L
T
G
D
---
K
A
T
K
L
S
I
------
Q
-
V
G
----
D
P
--
F
A
E
K
M
L
I
E
A
F
L
E
--
M
V
E
---
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
---------------------------
D
------
M
-------
E
P
W
E
I
---
L
-------------
I
-
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
--
H
-
L
L
F
G
D
-
V
V
A
E
V
I
E
E
P
--
V
Y
R
V
M
Y
R
--
N
D
L
V
M
-
E
V
P
V
Q
L
L
A
-
N
A
P
E
E
D
I
V
E
Y
T
P
G
-
K
-
I
----
P
E
F
K
R
V
-----------
E
F
E
E
V
N
A
R
E
V
F
E
Q
Y
D
H
M
V
G
T
D
T
V
V
P
P
--------
G
F
G
A
A
V
---
M
R
I
K
R
--
D
G
G
Y
S
L
V
T
H
S
---
R
A
D
L
--
A
L
Q
D
T
Y
W
G
T
L
I
A
V
L
E
S
V
R
K
T
L
S
V
G
A
E
P
---
L
A
-
I
T
N
C
V
N
Y
G
D
P
D
V
-
D
---
P
V
G
L
S
A
M
M
T
A
L
K
-
N
A
C
E
F
S
G
V
P
V
A
S
G
N
A
S
L
Y
N
T
Y
Q
--------
G
K
P
I
P
P
T
L
V
V
G
M
L
G
K
V
N
P
-
Q
K
V
A
K
----
P
K
-
P
S
K
V
F
A
V
G
W
N
------
D
-------------------------
F
-----
E
L
--
E
R
E
K
---
E
L
W
R
A
I
R
K
L
S
E
-
E
G
A
F
I
L
S
S
S
Q
L
----
L
T
R
T
H
V
E
T
F
R
--
E
Y
G
L
-----
K
I
E
V
-
K
L
P
EVRPA--
H
------------
Q
-------------
M
-
V
---
L
V
F
S
E
-
R
T
-
P
-
V
V
D
V
P
V
K
E
I
G
T
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
46.97
25%
16
- C4 -
-
3VIU
2
PURL_THET8
A:
[17-656]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
V
Q
-
R
L
G
R
E
P
-
N
R
V
E
L
L
L
F
K
V
M
W
S
E
H
C
A
Y
K
----------
N
S
R
P
L
-----
L
K
A
L
P
K
E
G
E
A
---
V
L
Q
G
--
P
G
E
N
A
G
V
V
R
V
G
--------------------------
E
G
W
A
V
A
F
K
I
E
S
H
N
H
-
P
S
A
V
--
E
P
F
Q
G
A
A
T
G
V
G
G
I
L
R
D
--
I
M
S
M
G
A
R
P
I
A
-
L
L
D
S
L
----------------
R
F
G
P
P
E
E
A
R
S
--
R
Y
L
L
K
G
V
V
S
G
I
A
-
F
Y
G
N
A
I
G
V
P
T
V
G
G
D
L
Y
F
H
--------------
E
G
Y
R
E
N
P
L
V
N
A
M
C
L
G
L
L
R
E
E
-
H
-
L
K
R
S
R
A
S
L
G
R
P
I
Y
Y
A
G
A
K
T
G
R
D
G
I
---------------------------------
V
G
----
D
P
--
F
L
G
K
L
L
M
E
A
T
L
E
--
A
I
E
L
---
D
L
V
E
G
V
Q
D
M
G
A
A
G
L
T
S
S
L
S
E
L
A
H
K
S
G
L
G
V
E
L
H
L
D
L
V
P
T
R
E
E
---------------------------
G
------
M
-------
T
P
E
E
L
---
L
-------------
L
-
S
E
-
S
Q
E
R
M
V
L
V
P
K
E
G
K
E
K
A
L
E
E
V
F
G
R
--
W
-
G
L
D
C
V
-
P
V
A
R
T
I
P
E
R
--
V
F
R
V
---
L
F
R
G
E
V
V
A
E
V
P
T
E
A
L
A
E
A
P
T
Y
V
R
V
G
R
E
D
P
E
V
R
R
L
R
E
TP
I
P
P
L
E
A
D
P
Q
E
V
L
R
R
L
L
A
S
P
N
L
A
S
R
E
A
V
Y
E
R
Y
D
H
Q
V
G
T
R
T
A
--
L
L
P
G
K
-----
G
D
A
A
V
L
W
I
K
G
T
R
L
----
G
V
A
A
K
V
D
Q
---
N
P
R
Y
--
S
R
L
H
P
R
L
G
A
M
H
A
L
A
E
A
C
R
N
V
S
V
V
G
A
K
P
L
A
Y
T
D
--
G
L
N
L
G
S
P
E
T
-
P
-
E
G
-
Y
H
E
-
L
A
E
T
I
A
G
L
-
K
E
A
S
E
A
L
G
V
P
V
V
S
G
N
V
S
L
-----
Y
N
E
S
G
G
K
R
I
---
P
P
T
A
M
V
G
V
V
G
V
L
-
E
V
D
K
R
A
E
M
G
F
R
R
-
P
G
E
V
L
L
L
I
G
E
E
R
G
E
L
G
A
S
E
V
L
Y
-
L
L
T
-
G
K
E
------
F
G
-
H
--
P
P
--
R
L
D
-
L
--
G
R
E
K
---
A
V
Q
E
A
I
R
D
L
I
Q
-
R
G
-
L
T
R
T
A
H
D
V
A
E
G
G
L
L
L
A
L
A
E
M
T
F
P
Y
G
V
G
A
-----
T
V
E
V
R
E
---------
E
------------
G
-------------
L
-
E
---
A
L
F
G
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
41.47
15%
-41
- C4 -
-
2HS3
1
PURL_THEMA
A:
[49-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
F
E
G
N
A
G
V
---
V
N
L
D
D
--
Y
Y
S
V
A
F
K
I
E
S
---
H
N
H
P
--
S
A
I
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
V
L
A
M
G
A
R
P
---
T
A
-
I
F
D
S
L
H
M
S
R
----------
I
I
D
G
I
I
E
G
I
A
-
D
Y
G
N
S
I
G
V
P
T
V
G
G
E
L
R
I
S
S
L
Y
A
-----------
H
N
P
L
V
N
V
L
A
A
G
V
V
R
N
-
D
M
L
V
D
S
K
A
S
R
P
-
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
-
A
S
E
D
L
T
G
D-----
K
A
-
T
K
L
S
I
--
Q
V
G
D
P
--
F
A
E
K
---
M
L
I
E
A
F
L
E
M
V
E
-
E
G
-
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
-----
I
V
H
L-
D
RVPLREPDM
E
------------
P
-------------
W
-
E
---
I
L
I
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
A
R
K
--
H
--
L
L
F
-
G
D
-
V
V
A
E
V
I
E
E
P
-
V
Y
R
V
M
Y
R
N
DLV--
M
E
V
P
V
Q
L
L
A
N
A
P
E
E
D
I
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
40.20
26%
10
- C4 -
-
2HS4
2
PURL_THEMA
A:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
Y
L
N
I
L
K
E
-
K
L
G
R
E
P
-
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
-------------------
Y
S
H
T
K
K
Y
I
R
R
L
P
K
-----
T
G
--
F
E
G
N
A
G
V
V
-
N
L
D
D
---------------------
Y
Y
S
V
A
----
F
K
I
E
S
H
N
H
-
P
S
A
I
--
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
G
A
R
P
T
A
-
I
F
D
S
L
H
M
S
R
I
--------------------------
I
D
G
I
I
E
G
I
A
D
Y
-
G
N
S
I
G
V
P
T
V
G
G
--
E
L
R
I
S
S
L
Y
A
-----------
H
N
-
P
L
V
N
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
----
L
T
G
-
D
K
A
T
K
L
S
I
------
Q
-
V
G
----
D
P
--
F
A
E
K
M
---
L
I
E
A
--
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
---------------------------
D
------
M
-------
E
P
W
E
I
---
L
-------------
I
-
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
-
A
R
--
K
-
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
--
V
Y
R
V
---
M
Y
R
N
D
L
V
M
E
V
P
V
Q
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
40.01
26%
12
- C4 -
-
2HS3
1
PURL_THEMA
A:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
Y
L
N
I
L
K
E
-
K
L
G
R
E
P
-
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
-------------------
Y
S
H
T
K
K
Y
I
R
R
L
P
K
-----
T
G
--
F
E
G
N
A
G
V
V
-
N
L
D
D
---------------------
Y
Y
S
V
A
----
F
K
I
E
S
H
N
H
-
P
S
A
I
--
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
G
A
R
P
T
A
-
I
F
D
S
L
H
M
S
R
I
--------------------------
I
D
G
I
I
E
G
I
A
D
Y
-
G
N
S
I
G
V
P
T
V
G
G
--
E
L
R
I
S
S
L
Y
A
-----------
H
N
-
P
L
V
N
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
H
G
A
S
F
A
S
E
D
----
L
T
G
-
D
K
A
T
K
L
S
I
------
Q
-
V
G
----
D
P
--
F
A
E
K
M
---
L
I
E
A
--
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
---------------------------
D
------
M
-------
E
P
W
E
I
---
L
-------------
I
-
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
-
A
R
--
K
-
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
--
V
Y
R
V
---
M
Y
R
N
D
L
V
M
E
V
P
V
Q
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
39.85
26%
0
- C4 -
-
2HS0
2
PURL_THEMA
A:
[2-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
Y
L
N
I
L
K
E
-
K
L
G
R
E
P
-
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
-------------------
Y
S
H
T
K
K
Y
I
R
R
L
P
K
-----
T
G
--
F
E
G
N
A
G
V
V
-
N
L
D
D
---------------------
Y
Y
S
V
A
----
F
K
I
E
S
H
N
H
-
P
S
A
I
--
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
G
A
R
P
T
A
-
I
F
D
S
L
H
M
S
R
I
--------------------------
I
D
G
I
I
E
G
I
A
D
Y
-
G
N
S
I
G
V
P
T
V
G
G
--
E
L
R
I
S
S
L
Y
A
-----------
H
N
-
P
L
V
N
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
------------------------
I
------
Q
-
V
G
----
D
P
--
F
A
E
K
M
---
L
I
E
A
--
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
---------------------------
D
------
M
-------
E
P
W
E
I
---
L
-------------
I
-
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
-
A
R
--
K
-
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
--
V
Y
R
V
---
M
Y
R
N
D
L
V
M
E
V
P
V
Q
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
39.47
26%
-2
- C4 -
-
2HRY
1
PURL_THEMA
A:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
Y
L
N
I
L
K
E
-
K
L
G
R
E
P
-
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
-------------------
Y
S
H
T
K
K
Y
I
R
R
L
P
K
-----
T
--------
G
V
V
-
N
L
D
D
---------------------
Y
Y
S
V
A
----
F
K
I
E
S
A
N
H
-
P
S
A
I
--
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
G
A
R
P
T
A
-
I
F
D
S
L
H
M
S
R
I
--------------------------
I
D
G
I
I
E
G
I
A
D
Y
-
G
N
S
I
G
V
P
T
V
G
G
--
E
L
R
I
S
S
L
Y
A
-----------
H
N
-
P
L
V
N
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
---------------------------------
V
G
----
D
P
--
F
A
E
K
M
---
L
I
E
A
--
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
---------------------------
D
------
M
-------
E
P
W
E
I
---
L
-------------
I
-
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
-
A
R
--
K
-
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
--
V
Y
R
V
---
M
Y
R
N
D
L
V
M
E
V
P
V
Q
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
38.26
17%
-32
- C4 -
-
3MCQ
8
?
A:
[18-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
--
A
V
L
G
--
V
G
D
D
A
A
L
I
-
Q
P
S
P
G
----
M
E
L
A
V
S
A
D
-------------
M
---
L
V
A
N
T
H
F
Y
-
P
N
I
---
D
P
W
L
I
G
W
K
S
L
A
V
N
I
S
D
M
A
A
M
--
G
A
Q
P
R
W
-
A
T
L
T
I
A
L
P
E
A
--
D
-------------------
E
D
W
I
S
K
F
A
A
G
F
F
A
-
C
-
A
A
Q
F
D
I
A
L
I
G
G
--
D
T
T
R
--------------
G
--
P
-
L
T
I
S
V
Q
I
M
G
E
T
P
P
G
-
A
S
L
L
R
S
T
A
R
A
D
D
D
I
W
V
S
G
P
L
----
G
D
A
A
L
A
L
A
A
I
Q
--
G
R
Y
----
P
L
S
D
T
E
L
------
A
-
A
C
----------
G
K
A
L
H
Q
P
Q
P
R
V
V
L
G
Q
A
L
-
R
G
L
A
H
S
A
L
D
I
S
D
-
G
L
L
A
D
L
G
H
I
L
E
H
S
Q
V
G
A
E
V
W
L
K
A
I
P
K
S
E
V
---------------------------
V
S
A
H
SQE
V
-------
A
I
Q
K
M
---
I
L
------------
S
G
G
D
-
D
Y
E
-
L
C
F
T
A
S
T
Q
H
R
Q
Q
I
A
D
I
G
R
Q
--
L
-
S
L
D
M
A
-
V
I
G
R
I
T
D
T
Q
--
Q
L
V
I
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
37.46
16%
-26
- C4 -
-
5CM7
4
?
A:
[9-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
E
F
S
I
I
D
Q
Y
F
N
R
Q
S
H
P
D
V
A
L
--------
G
I
G
D
D
S
A
L
---
I
T
P
P
P
--
N
Q
Q
L
V
I
C
A
D
T
L
V
-
A
G
R
H
FP
L
E
T
S
P
H
A
I
G
W
K
S
V
A
V
N
L
S
D
I
A
A
M
G
A
K
P
---
H
S
-
I
L
L
A
I
S
L
P
Q
V
------
D
H
E
W
L
E
G
F
S
Q
G
I
Y
-
D
C
C
N
Q
F
G
V
A
L
I
G
G
D
T
T
Q
G
P
---------------
H
L
T
I
T
V
T
A
M
G
W
I
E
T
G
-
K
A
V
L
R
S
G
A
K
V
-
G
D
Y
V
C
V
S
G
Q
I
----
G
D
A
A
Y
G
L
-
Q
H
L
-
G
H
S
------
L
Q
-
Q
R
-
L
D
--
Y
---
P
--
T
------
P
R
C
K
L
G
E
E
L
---
K
G
-
L
A
S
S
M
I
D
V
S
D
-
G
L
A
Q
D
L
G
H
I
L
K
A
S
K
V
G
A
-----
R
L
I
L-
E
KLPV-----
D
P
V
L
Q
Q
IE
E
Q
Q
--
R
-------------
W
Q
Y
---
A
L
A
G
G
D
D
Y
-
E
L
C
F
T
I
T
P
Q
N
Y
E
K
L
L
Q
K
--
Q
--
L
--
D
V
K
-
I
T
-
M
I
G
Q
I
V
E
Q
T
-
K
L
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
37.13
26%
2
- C4 -
-
2HRU
1
PURL_THEMA
A:
[2-337]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
R
Y
L
N
I
L
K
E
-
K
L
G
R
E
P
-
T
F
V
E
L
Q
A
F
S
V
M
W
S
E
H
C
G
-------------------
Y
S
H
T
K
K
Y
I
R
R
L
P
K
-----
T
G
--
F
E
G
N
A
G
V
V
-
N
L
D
D
---------------------
Y
Y
S
V
A
----
F
K
I
E
S
A
N
H
-
P
S
A
I
--
E
P
Y
N
G
A
A
T
G
V
G
G
I
I
R
D
--
V
L
A
M
G
A
R
P
T
A
-
I
F
D
S
L
H
M
S
R
I
--------------------------
I
D
G
I
I
E
G
I
A
D
Y
-
G
N
S
I
G
V
P
T
V
G
G
--
E
L
R
I
S
S
L
Y
A
-----------
H
N
-
P
L
V
N
V
L
A
A
G
V
V
R
N
D
-
M
L
V
D
S
K
A
S
R
P
G
Q
V
I
V
I
F
G
G
A
T
G
R
D
G
I
---------------------------------
V
G
----
D
P
--
F
A
E
K
M
---
L
I
E
A
--
F
L
E
M
V
E
E
G
L
V
E
G
A
Q
D
L
G
A
G
G
V
L
S
A
T
S
E
L
V
A
K
G
N
L
G
A
I
V
H
L
D
R
V
P
L
R
E
P
---------------------------
D
------
M
-------
E
P
W
E
I
---
L
-------------
I
-
S
E
-
S
Q
E
R
M
A
V
V
T
S
P
Q
K
A
S
R
I
L
E
I
-
A
R
--
K
-
H
L
L
F
G
D
V
V
A
E
V
I
E
E
P
--
V
Y
R
V
---
M
Y
R
N
D
L
V
M
E
V
P
V
Q
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
36.67
18%
-10
- C4 -
-
3U0O
-
SELD_ECOLI
B:
[13-338]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
G
A
G
C
G
C
K
I
S
P
K
V
L
E
-------
T
I
L
H
S
E
Q
A
K
---
F
V
D
P
N
--
L
L
V
G
NE
T
R
D
D
A
A
V
Y
-
D
L
G
N
-------------------------
G
T
S
V
I
S
T
T
D
F
F
-
M
-
P
I
V
D
--
N
P
F
D
F
G
R
I
A
A
T
N
A
I
S
D
I
F
A
M
--
G
G
K
P
I
M
-
A
I
A
I
L
G
W
P
I
N
K
L
-------------------
S
P
E
I
A
R
E
V
T
E
G
G
R
Y
-
A
-
C
R
Q
A
G
I
A
L
A
G
G
--
H
S
I
D
--------------
A
-
P
E
-
P
I
F
G
L
A
V
T
G
I
V
P
T
E
-
R
V
K
K
N
S
T
A
Q
A
G
C
K
L
F
L
T
K
P
L
----
G
I
G
V
L
T
T
A
E
K
K
---
S
-----
L
L
K
P
E
H
Q
------
G
-
L
A
----
T
E
--
V
M
-
C
R
M
N
I
A
-----
G
A
S
F
A
N
I
E
G
V
K
A
M
T
D
V
T
G
F
G
L
L
G
H
L
S
E
M
C
Q
G
A
G
V
Q
A
R
V
D
Y
E
A
I
P
K
L
P
G
V
E
E
Y
I
K
L
GAVPG
G
T
E
R
-----------
N
------
F
-------
A
S
Y
G
H
---
L
MGEMP
R
E
V
R
D
L
L
C
D
-
P
Q
-
T
S
G
G
L
L
L
A
V
M
P
E
A
E
N
E
V
K
A
T
A
A
E
--
F
-
G
I
E
L
T
-
A
I
G
E
L
V
P
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
35.38
13%
-40
- C4 -
-
3FD5
2
SPS1_HUMAN
B:
[67-379]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
G
M
D
T
C
V
---
I
P
L
R
H
G
-
G
L
S
L
V
Q
T
T
D
Y
---
I
Y
P
I
---
V
D
D
P
Y
M
M
G
R
I
A
C
A
N
V
L
S
D
L
Y
A
M
G
V
T
E
---
C
D
N
M
L
M
L
L
G
V
S
N
K
-
M
T
D
R
E
R
D
K
V
M
P
L
I
I
Q
G
F
K
-
D
A
A
E
E
A
G
T
S
V
T
G
G
Q
T
V
L
N
P
---------------
W
I
V
L
G
G
V
A
T
T
V
C
Q
P
-
N
E
F
I
M
P
D
N
A
V
P
-
G
D
V
L
V
L
T
K
P
L
----
G
T
Q
V
A
V
A
V
H
Q
W
-
L
D
I
P
E
K
W
N
K
I
K
-
L
V
-
V
T
Q
E
D
V
E
L
A
Y
Q
E
A
M
M
N
M
A
R
L
N
R
T
A
A
G
L
M
H
-
T
F
-
N
A
H
A
A
T
D
I
T
G
F
G
I
L
G
H
A
Q
N
L
A
K
Q
Q
R
N
E
V
-----
S
F
V
I
-
H
N
L
P
V
-----
L
AK
M
A
A
V
S
K
A
C
GN
M
-------------
F
-
G
LMH
G
T
C
P
E
-
T
S
G
G
L
L
I
C
L
P
R
E
Q
A
A
R
F
C
A
E
I
K
S
--
P
E-
G
H
Q
-
A
W
-
I
I
G
I
V
E
K
G
N
R
T
A
R
I
I
D-
K
P
R
I
--
I
E
V
A
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
34.88
17%
-6
- C4 -
-
2Z1U
1
?
A:
[38-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
N
D
A
A
R
---
L
D
L
T
----
G
P
L
A
M
S
T
D
S
Y
TV
D
P
I
F
----
F
P
G
G
D
I
G
T
L
A
V
H
G
T
V
N
D
V
S
M
L
G
A
R
P
---
R
Y
-
L
S
C
G
F
I
L
E
E
G
-
L
----
D
M
D
I
L
E
R
V
V
A
S
M
G
-
K
A
A
R
E
A
G
V
F
I
V
T
G
D
T
K
V
V
P
R
G
A
----------
C
D
K
M
F
I
N
T
T
G
I
G
E
I
L
V
-
D
P
A
P
S
G
D
R
A
R
P
-
G
D
A
I
L
I
S
G
S
------
M
G
D
H
G
L
-
T
I
L
-
S
Q
R
------
Q
G
-
L
N
-
F
A
--
A
D
-
V
C
--
S
D
S
A
---
S
L
N
R
V
V
E
K
L
V
L
E
V
G
-
D
I
H
V
L
R
D
P
T
R
G
G
L
A
T
T
L
N
E
I
A
G
Q
S
Q
A
V
C
-----
H
V
L
E-
T
A
V
P
V
-----
R
------------
E
S
V
R
N
G
C
S
F
L
G---
L
-
D
PL-
Y
L
A
N
E
--
G
-
K
L
I
C
I
L
P
E
E
R
A
E
A
A
L
A
V
L
R
E
--
G
PH
G
E
H
-
A
A
-
R
I
G
S
V
K
S
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
34.87
18%
-4
- C4 -
-
2YYE
2
SELD_AQUAE
B:
[3-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
I
E
-
G
R
H
M
V
E
L
L
K
L
V
R
S
S
G
C
A
A
K
V
G
P
G
D
L
Q
E
-------
I
L
K
G
F
N
I
Y
T
----
D
E
S
--
T
L
V
S
--
I
G
D
D
A
G
V
Y
-
E
H
N
-
G
----
I
---------------------
I
W
V
Y
T
V
D
I
I
T
--
P
V
V
N
--
D
P
Y
L
W
G
A
I
S
T
A
N
A
L
S
D
V
Y
A
M
--
G
G
I
P
V
N
-
A
L
A
I
S
C
F
N
N
C
E
L
-------------------
D
I
E
I
F
R
E
V
I
R
G
A
L
D
-
K
-
L
R
E
A
K
T
V
L
L
G
G
--
H
T
I
D
--------------
D
-
K
E
-
P
K
F
G
L
S
V
A
G
I
C
P
E
G
-
K
Y
I
T
Q
S
G
A
Q
V
G
Q
L
L
I
L
T
K
P
I
----
G
--
T
G
I
L
I
K
G
L
--
K
E
G
----
I
L
K
E
E
D
I
------
N
-
E
----------
A
I
E
N
M
L
A
L
N
D
K
--
A
R
N
L
M
L
S
L
D
A
T
A
C
T
D
V
T
G
F
G
L
L
G
H
A
W
N
I
C
K
N
S
N
I
G
A
R
I
F
F
E
K
V
P
Y
Y
Q
L
S
E
N
L
V
K
K
KIYPK
G
A
I
E
N
L
N
F
V
KNYLKS
N
------
L
-------
D
N
W
K
L
I
L
-
L
-------------
S
-
D
P
V
T
S
G
G
L
L
F
T
I
N
K
E
K
L
E
K
I
D
E
T
A
K
E
--
L
-
E
V
N
Y
W
-
I
I
G
E
T
I
A
E
N
--
V
L
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
33.48
18%
-1
- C4 -
-
3U0O
-
SELD_ECOLI
A:
[29-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
H
S
E
Q
A
K
---
F
V
D
P
N
--
L
L
V
G
NE
T
R
D
D
A
A
V
Y
-
D
L
G
N
-------------------------
G
T
S
V
I
S
T
T
D
F
F
-
M
-
P
I
V
D
--
N
P
F
D
F
G
R
I
A
A
T
N
A
I
S
D
I
F
A
M
--
G
G
K
P
I
M
-
A
I
A
I
L
G
W
P
I
N
K
L
-------------------
S
P
E
I
A
R
E
V
T
E
G
G
R
Y
-
A
-
C
R
Q
A
G
I
A
L
A
G
G
--
H
S
I
D
--------------
A
-
P
E
-
P
I
F
G
L
A
V
T
G
I
V
P
T
E
-
R
V
K
K
N
S
T
A
Q
A
G
C
K
L
F
L
T
K
P
L
----
G
I
G
V
L
T
T
A
E
K
K
---
S
-----
L
L
K
P
E
H
Q
------
G
-
L
A
----
T
E
--
V
M
-
C
R
M
N
I
A
-----
G
A
S
F
A
N
I
E
G
V
K
A
M
T
D
V
T
G
F
G
L
L
G
H
L
S
E
M
C
Q
G
A
G
V
Q
A
R
V
D
Y
E
A
I
P
K
L
P
G
V
E
E
Y
I
KLGAVP
G
G
T
E
R
-----------
N
------
F
-------
A
S
Y
G
H
---
L
MGEMP
R
E
V
R
D
L
L
C
D
-
P
Q
-
T
S
G
G
L
L
L
A
V
M
P
E
A
E
N
E
V
K
A
T
A
A
E
--
F
-
G
I
E
L
T
-
A
I
G
E
L
V
P
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
33.45
17%
14
- C4 -
-
2Z01
-
PUR5_GEOKA
A:
[32-342]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
--
V
L
G
-------
G
G
L
F
-
D
L
S
A
L
GYR
Q
P
V
L
I
S
G
T
D
-------------
G
-----
V
G
T
K
L
K
-
L
A
F
L
L
D
R
H
D
T
I
G
I
D
C
V
A
M
C
V
N
D
I
I
V
Q
--
G
A
E
P
L
F
-
F
L
D
Y
I
A
C
G
K
A
V
---------------------
P
E
K
I
A
A
I
V
K
G
V
A
D
-
G
-
C
V
E
A
G
C
A
L
I
G
G
--
E
T
A
E
-----------------
E
-
Y
D
L
A
G
F
A
V
G
V
A
E
K
E
R
L
-
I
T
G
E
T
I
Q
A
G
D
A
L
V
G
L
P
S
S
----
G
L
H
S
N
G
Y
S
L
V
R
R
I
V
F
E
Q
--
A
K
L
S
L
D
E
I
YEPLDV
P
-
L
G
E
E
L
L
K
P
--
T
--
R
I
Y
A
K
L
L
R
S
--
V
R
---
E
R
F
T
I
K
G
M
A
H
I
T
G
G
G
L
I
E
N
I
P
R
M
L
P
-
P
G
I
G
A
R
I
Q
L
G
S
W
P
I
L
P
I
F
D
F
L
R
E
K
G
-------------------
S
------
L
-------
E
E
E
E
M
---
F
S
V-----------
F
-
N
M
-
G
I
-
G
L
V
L
A
V
S
P
E
T
A
A
P
L
V
E
W
L
S
E
--
R
-
G
E
P
A
Y
-
I
I
G
E
V
A
K
G
A
--
G
V
S
F
A
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
HHSearch
31.83
14%
-6
- C4 -
-
3FD5
2
SPS1_HUMAN
B:
[8-379]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
F
N
-
P
E
S
Y
E
L
D
K
S
F
R
L
T
R
F
--
T
E
L
K
G
T
G
C
K
V
P
Q
D
V
L
Q
-------
K
L
L
E
S
L
-----------V
M
P
R
L
G
--
I
G
M
D
T
C
V
I
-
P
L
R
H
------------------------
G
G
L
S
L
V
Q
T
T
D
Y
I
-
Y
-
P
I
V
D
--
D
P
Y
M
M
G
R
I
A
C
A
N
V
L
S
D
L
Y
A
M
--
G
V
T
E
C
D
N
M
L
M
L
L
G
V
S
N
K
M
T
D
R
----------------
E
R
D
K
V
M
P
L
I
I
Q
G
F
K
D
-
A
-
A
E
E
A
G
T
S
V
T
G
G
--
Q
T
V
L
--------------
N
-
P
W
-
I
V
L
G
G
V
A
T
T
V
C
Q
P
N
-
E
F
I
M
P
D
N
A
V
P
G
D
V
L
V
L
T
K
P
L
----
G
T
Q
V
A
V
A
V
H
Q
W
--
L
D
I
P
E
K
W
N
K
I
K
L
V
V
------
T
-
Q
E
D
V
E
-
L
A
Y
Q
E
A
M
M
N
M
A
R
L
N
R
T
--
A
A
G
L
M
H
T
F
N
A
H
A
A
T
D
I
T
G
F
G
I
L
G
H
A
Q
N
L
A
K
Q
Q
R
N
E
V
S
F
V
I
H
N
L
P
V
L
A
K
---------------------------
M
------
A
A
V
S
K
A
C
G
N
M
F
G
L
MHG
T
-------------
C
-
P
E
-
T
S
G
G
L
L
I
C
L
P
R
E
Q
A
A
R
F
C
A
E
I
K
S
--
P
E
G
H
Q
A
W
-
I
I
G
I
V
E
K
G
N
R-
T
A
R
I
-
I
D
--
K
P
R
I
I
-
E
V
A
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
31.05
13%
-2
- C4 -
-
3VTI
-
?
D:
[18-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
M
E
D
A
A
L
---
L
F
------
G
N
I
T
L
T
T
D
S
---
F
T
V
K
P-
L
F
F
P
G
G
D
I
G
K
L
A
V
C
G
T
V
N
D
A
S
M
R
G
A
K
P
---
L
F
-
L
T
A
A
F
I
I
E
E
G
-
F
----
P
V
E
D
L
K
K
I
V
K
S
M
A
-
E
A
A
K
E
A
G
V
K
I
V
A
G
D
T
K
V
V
E
K
G
S
V
----------
D
R
I
F
I
N
T
S
G
I
G
V
L
Y
E
G
-
A
N
V
S
I
K
N
A
K
P
-
G
D
I
V
L
I
S
G
T
I
----
G
D
H
G
M
A
V
-
M
S
A
-
R
E
E
------
L
Q
F
D
T
-
P
I
--
F
-
S
D
V
--
A
P
L
N
---
G
L
I
E
K
L
M
T
L
---
G
E
-
A
I
K
V
L
R
D
P
T
R
G
G
V
A
E
V
L
Y
E
I
S
K
M
S
G
V
G
I
-----
K
I
Y
E-
E
K--------
L
------------
P
VKESVKSACEFMG
I
-
D
---
F
L
H
L
A
-
N
E
G
K
V
V
V
V
V
E
R
D
Y
A
E
K
A
L
E
I
M
K
S
HE
Y
--
G
K
D
-
A
E
-
I
I
G
E
V
N
D
S
K
-
L
V
T
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
30.28
19%
18
- C4 -
-
3VYT
-
?
C:
[35-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
I
G
L
D
--
A
L
D
D
G
A
T
I
-
P
F
G
--------------------------
D
K
H
I
V
F
T
I
D
G
H
T
V
K
P
L
F
F
--
P
G
G
D
I
G
R
L
A
V
S
G
T
V
N
D
L
A
V
M
--
G
A
E
P
I
A
-
L
A
N
S
M
I
I
G
E
G
L
--------------------
D
M
E
V
L
K
R
V
L
K
S
M
D
E
-
T
-
A
R
E
V
P
V
P
I
V
T
G
--
D
T
K
V
V
E
D
------------
K
I
E
-
M
F
V
I
T
A
G
I
G
I
A
E
-
H
-
P
-
V
S
D
A
G
A
K
V
G
D
A
V
L
V
S
G
T
I
----
G
D
H
G
I
A
L
M
S
H
R
--
E
G
------
I
A
F
E
T
E
L-----
K
S
D
V
----
A
P
--
I
--
W
D
---
V
V
K
A
--
V
A
E
T
I
G
W
E
N
I
H
A
M
K
D
P
T
R
A
G
L
S
N
A
L
N
E
I
A
R
K
S
N
V
G
I
L
V
R
E
A
D
I
P
I
R
P
E
V
R
A
A
S
E
M
L
-------------------
G
------
I
-------
S
P
Y
D
V
---
A
------------------
N
E
G
K
V
V
M
V
V
A
R
E
Y
A
E
E
A
L
E
A
M
R
K
TE
K
-
G
R
N
A
A
-
I
I
G
E
V
I
A
D
Y
RG
K
V
L
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------