@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTC6: (2017-12-12 )
MSVHFLHTSDWHLGQFFYNHSRHYEHQQFLSWLLTQIQEKQPHALLIAGDIFDVINPGSQAQKQLYQFLADAHRIAPHMQTLMIAGNHDSGYRIEQVEPLLEKYNAKTVGVVRWNEDKTLDLDRLLLPIYNQNQDIVAWCLALPFLRSAEITGFNEHTTNSKNAIAYLHQQLIAEAKRRKTPDQALILMSHAHMQGGETSDSERPIIIGNEEALSTTLFEDAVDYVALGHLHKPQKVGQPHIRYSGSPIPLSFSEINYKHQVVEVKIDPSQDIDSRLQFEAVEIPRCIQLHRIRGELNEVLQQLKALPHGVIENIDHREYVDIEYYSLTPPQPNLRQQFEAALPPDRYRLVRISRQYVNKDTTNSNTTQHIALEPPTPEKLFQNIWEKQGYSADDAVLKDFLSLVQEAQKHLENDASH
Atome Classification :
(20 SA)
.........10...-.....----20........30........40........50...-.....60........70------------...-------------------------.....80........90.....--...100...-.-....110.......120.......130.......140.......150---....--....160--.--........170.....-.-.180.......190....--....200.......210.......220.......230.....-.------.-----240.......250...--....260.......270.......280.......290..---.....300.......310.......320.......330........340.......350.......360.---......370.......380.......390.......400.......410......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
V
H
F
L
HTSDW
H
L
G
-
Q
F
F
Y
N----HSR
H
Y
E
H
Q
Q
F
L
S
W
L
L
T
Q
I
QEKQP
H
A
L
L
I
A
G
D
I
F
D
V-INP
G
S
Q
A
Q
K
Q
L
Y
Q
F
L
A
D
------------
A
H
R
-------------------------
I
A
P
H
M
Q
T
L
M
I
AGNHDSGY
R
I
E
Q
--
V
E
P
L
L
-
E
KY-N-A
K
T
V
G
V
V
R
WNEDKTL
D
L
D
R
L
L
L
P
IYNQN
Q
D
I
V
A
W
C
L
A
L
P
F
LRSAEI----TGFN--EHTTN----S--
K
N
A
I
A
Y
L
H
Q
Q
L
I
A
E
A
K
-R-RKTPD
Q
A
L
I
L
M
S
H-AHMQ--GGETSDSER
P
I
I
IG
N
E
E
A
L
S
T
T
L
F
E
D
A
V
D
Y
V
A
LGHLHKPQKV-G------Q-----P
H
I
R
YSGSPI
P
L
S
F
SE--IN
Y
K
H
Q
V
V
E
V
K
IDPSQ
D
I
D
S
R
L
Q
F
EAVEI
P
R
C
I
Q
L
H
R
I
R
---
G
E
L
N
E
V
L
Q
Q
L
K
ALP
H
G
V
I
ENIDHR
E
Y
V
D
I
E
Y
Y
SLTP-PQ
P
N
L
R
Q
Q
F
E
AALPP
D
R
Y
R
L
V
R
I
S
R
Q
Y
VNKDTT---NSNT
T
Q
H
I
A
LEPP
T
P
E
K
L
F
Q
N
I
W
E
KQGYSA
D
D
A
V
L
K
D
F
L
S
L
V
Q
E
A
Q
K
H
L
ENDASH
3
PsiBlast_PDB
99.07
33%
0
- C- -
-
4LU9
2
?
C:
[15-314]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
I
TS
Q
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
95.95
33%
0
- C- -
-
4M0V
1
?
A:
[15-313]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ------
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
95.46
33%
-37
- C1 -
-
4M0V
1
?
B:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
I
TSQ
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
95.31
33%
-40
- C1 -
-
4LTY
1
?
B:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.87
33%
-48
- C1 -
-
4LTY
1
?
C:
[15-315]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ------
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
94.09
33%
-35
- C1 -
-
4LTY
1
?
A:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
G
I
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
93.97
33%
-34
- C1 -
-
4M0V
1
?
C:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
G
I
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
93.87
33%
-33
- C1 -
-
4LU9
1
?
D:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
TV
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
93.58
33%
-36
- C1 -
-
4LTY
1
?
D:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
TV
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
93.57
33%
-41
- C1 -
-
4LU9
1
?
B:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
I
TSQ
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
93.41
33%
-31
- C1 -
-
4LU9
2
?
A:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
G
I
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
T
V
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
92.99
33%
-37
- C1 -
-
4M0V
1
?
D:
[15-308]
--
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
Q
-------------------------
T
G
C
H
L
--
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
D
G
T
P
G
A
V
--
L
C
P
I
P
F
L
R
P
R
D
I
ITSQ
A
G
L
N
GI
E
K
Q
Q
H
----
L
--
L
A
A
I
T
D
Y
Y
Q
Q
H
Y
A
D
A
C
-
K
-
L
R
G
-
D
Q
P
L
P
I
I
A
T
-
G
H
L
T
TV
G
A
S
K
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
P
P
A
-
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
G
G
------
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
-
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
E
S
---
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
---------------------------------------------------------------------------------------------------------------------
30
HHSearch
90.29
31%
-38
- C1 -
-
4LTY
1
?
B:
[13-330]
E
F
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
--------------------------
Q
T
-
G
C
H
L
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
--
D
G
T
P
G
A
V
L
C
P
I
P
F
L
R
P
R
D
I
----
I
T
S
Q
--
A
G
L
N
G
IEKQ
Q
H
L
L
A
A
I
T
D
Y
Y
Q
Q
H
-
Y
A
D
A
C
K
L
R
G
D
Q
P
L
P
I
I
A
T
G
H
L
T
T
V
G
--
A
S
K
-
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
-
P
P
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
-
G
G-----
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
----
E
S
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
Q
W
R
D
V
---
S
Q
E
P
P
V
W
L
D
I
E
I
T
T
D
E
Y
--------------------------------------------------------------------------------------------
31
HHSearch
89.36
31%
-33
- C1 -
-
4LTY
1
?
A:
[13-330]
E
F
M
R
I
L
H
T
S
D
W
H
L
G
-
Q
N
F
Y
S
----
K
S
R
E
A
E
H
Q
A
F
L
D
W
L
L
E
T
A
Q
T
H
Q
V
D
A
I
I
V
A
G
D
V
F
D
T
-
G
S
P
P
S
Y
A
R
T
L
Y
N
R
F
V
V
N
------------
L
Q
--------------------------
Q
T
-
G
C
H
L
V
V
L
A
G
N
H
D
S
V
A
T
L
N
E
--
S
R
D
I
M
-
A
F
L
-
N
-
T
T
V
V
A
S
A
G
H
A
P
Q
--------
I
L
P
R
R
--
D
G
T
P
G
A
V
L
C
P
I
P
F
L
R
P
R
D
I
----
I
T
S
Q
--
A
G
L
N
G
I
E
K
Q
Q
H
L
L
A
A
I
T
D
Y
Y
Q
Q
H
-
Y
A
D
A
C
K
L
R
G
D
Q
P
L
P
I
I
A
T
G
H
L
T
T
V
G
--
A
S
K
-
S
D
A
V
R
D
I
Y
I
G
T
L
D
A
F
P
A
Q
N
F
-
P
P
A
D
Y
I
A
L
G
H
I
H
R
A
Q
I
I
-
G
G-----
M
-----
E
H
V
R
Y
C
G
S
P
I
P
L
S
F
D
E
--
C
G
K
S
K
Y
V
H
L
V
T
F
S
N
G
K
L
----
E
S
V
E
N
L
N
V
P
V
T
Q
P
M
A
V
L
K
---
G
D
L
A
S
I
T
A
Q
L
E
Q
W
R
D
V
---
S
Q
E
P
P
V
W
L
D
I
E
I
T
T
D
E
Y
--------------------------------------------------------------------------------------------
43
HHSearch
70.88
19%
-46
- C1 -
-
4FBW
-
RAD32_SCHPO
B:
[13-316]
-
T
I
R
I
L
I
S
S
D
P
H
V
G
-
Y
G
E
K
D
----
P
V
R
G
N
D
S
F
V
S
F
N
E
I
L
E
I
A
R
E
R
D
V
D
M
I
L
L
G
G
D
I
F
H
D
-
N
K
P
S
R
K
A
L
Y
Q
A
L
R
S
L
R
L
N
C
LGDKPCELEL
L
S
D
AVCNINYLDPNI-------------
N
V
-
A
I
P
V
F
S
I
H
G
N
H
D
D
-----
R
YS
A
L
D
I
L
-
Q
V
T
-
G
L
V
N
Y
F
G
R
V
P
E
N
D
N
--
I
V
V
S
P
I
L
L
----
Q
K
G
F
T
K
L
A
L
Y
G
I
S
N
V
R
D
E
R
L
----
Y
H
S
F
--
R
E
------------
N
K
V
K
F
L
R
P
-
D
L
Y
-------
R
D
E
W
F
N
L
L
T
V
H
Q
N
H
S
A
--
H
T
P
-----
T
-------
S
Y
L
P
E
S
F
I
Q
D
F
Y
D
F
V
L
W
G
H
E
H
E
C
L
I
D
-
G
S
Y
N
PTQ
K
-----
F
T
V
V
Q
P
G
S
T
I
A
T
S
L
S
P
GE
T
A
P
-
K
H
C
G
I
L
N
I
T
G
K
D
-----
F
H
L
E
K
I
R
L
R
T
V
R
P
F
I
M
K
D
---
I
I
L
S
----------------------------------------------------------------------------------------------------------------------------
40
HHSearch
70.73
17%
-50
- C1 -
-
3T1I
2
MRE11_HUMAN
D:
[32-335]
-
T
F
K
I
L
V
A
T
D
I
H
L
G
-
F
M
E
K
D
----
A
V
R
G
N
D
T
F
V
T
L
D
E
I
L
R
L
A
Q
E
N
E
V
D
F
I
L
L
G
G
D
L
F
H
E
-
N
K
P
S
R
K
T
L
H
T
C
L
E
L
L
R
K
------------
Y
C
M
GDRPVQFEILSDQSVNFGFSKFPNL
N
I
-
S
I
P
V
F
S
I
H
G
N
H
D
D
P
T
G
A
D
A
LC
A
L
D
I
L
-
S
C
A
G
F
-
V
N
H
F
G
R
S
M
S
V
E
--
K
I
D
I
S
P
V
L
L
--
Q
--
K
G
S
T
K
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
----
Y
R
M
F
--
V
N
------------
K
K
V
T
M
L
R
P
-
K
E
D
-------
E
N
S
W
F
N
L
F
V
I
H
Q
N
R
S
K
--
H
G
---
S
T
---------
N
F
I
P
E
Q
F
L
D
D
F
I
D
L
V
I
W
G
H
E
H
E
C
K
I
A
-
P
T-----
K
NEQQL
F
Y
I
S
Q
P
G
S
S
V
V
T
S
L
S
P
GE
A
V
K
-
K
H
V
G
L
L
R
I
K
G
R
K
-----
M
N
M
H
K
I
P
L
H
T
V
R
Q
F
F
M
E
D
---
I
V
L
A
----------------------------------------------------------------------------------------------------------------------------
42
HHSearch
70.22
19%
-37
- C1 -
-
4FBW
-
RAD32_SCHPO
A:
[13-316]
-
T
I
R
I
L
I
S
S
D
P
H
V
G
-
Y
G
E
K
D
----
P
V
R
G
N
D
S
F
V
S
F
N
E
I
L
E
I
A
R
E
R
D
V
D
M
I
L
L
G
G
D
I
F
H
D
-
N
K
P
S
R
K
A
L
Y
Q
A
L
R
S
L
R
L
N
C
LGDKPCELEL
L
S
-NINYLDPNI----------------
N
V
-
A
I
P
V
F
S
I
H
G
N
H
D
D
-----
R
YS
A
L
D
I
L
-
Q
V
T
-
G
L
V
N
Y
F
G
R
V
P
---
N
--
I
V
V
S
P
I
L
L
----
Q
K
G
F
T
K
L
A
L
Y
G
I
S
N
V
R
D
E
R
L
----
Y
H
S
F
--
R
E
------------
N
K
V
K
F
L
R
P
-
D
L
Y
-------
R
D
E
W
F
N
L
L
T
V
H
Q
N
H
S
A
--
H
T
P
-----
T
-------
S
Y
L
P
E
S
F
I
Q
D
F
Y
D
F
V
L
W
G
H
E
H
E
C
L
I
D
-
G
S
Y
N
PTQ
K
-----
F
T
V
V
Q
P
G
S
T
I
A
T
S
L
S
P
GE
T
A
P
-
K
H
C
G
I
L
N
I
T
G
K
D
-----
F
H
L
E
K
I
R
L
R
T
V
R
P
F
I
M
K
D
---
I
I
L
S
----------------------------------------------------------------------------------------------------------------------------
51
Fugue
67.80
20%
-17
- C1 -
-
1II7
1
MRE11_PYRFU
A:
[1-333]
--
M
K
F
A
H
L
A
D
I
H
L
G
Y
E
Q
F
H
K
----
P
Q
R
E
E
E
F
A
E
A
F
K
N
A
L
E
I
A
V
Q
E
N
V
D
F
I
L
I
A
G
D
L
F
H
S
-
S
R
P
S
P
G
T
L
K
K
A
I
A
L
L
Q
I
------------
P
K
E
---------------------------
H
S
I
P
V
F
A
I
E
G
N
H
D
R
T
Q
R
G
P
S
--
V
L
N
L
L
-
E
D
F
-
G
-
L
V
Y
V
I
G
M
R
---
K
E
K
V
E
N
E
Y
L
T
S
E
R
L
G
N
G
E
Y
L
V
K
G
V
Y
-----
K
D
L
E
I
----
H
G
M
K
--
Y
M
S
-------------
S
A
W
F
E
A
N
K
E
I
L
K
-
R
-
L
F
R
P
T
D
N
A
I
L
M
L
H
-
Q
G
V
R
--
E
V
S
E
A
R
G
E
D
Y
F
E
I
G
L
G
D
------
L
P
E
G
Y
L
Y
Y
A
L
G
H
I
H
K
R
Y
E
T
-
S
------
Y
SG---
S
P
V
V
Y
P
G
S
L
E
R
W
D
F
G
D
--
Y
E
V
R
Y
E
W
D
G
I
K
F
K
E
R
Y
G
V
N
K
G
F
Y
I
V
E
D
F
K
P
R
F
V
E
I
----------------------------
K
V
R
P
F
I
D
V
K
I
K
G
S
E
E
-
E
I
R
K
A
I
K
R
L
I
P
L
I
P
K
N
A
Y
V
R
L
N
I
G
W
R
-----------
K
P
F
D
L
T
E
I
K
E
L
L
N
V
E
Y
L
K
I
D
T
W
R
I
------------------------------
41
HHSearch
67.79
17%
-35
- C1 -
-
3T1I
8
MRE11_HUMAN
A:
[32-335]
-
T
F
K
I
L
V
A
T
D
I
H
L
G
-
F
M
E
K
D
----
A
V
R
G
N
D
T
F
V
T
L
D
E
I
L
R
L
A
Q
E
N
E
V
D
F
I
L
L
G
G
D
L
F
H
E
-
N
K
P
S
R
K
T
L
H
T
C
L
E
L
L
R
K
------------
Y
C
M
GDRPVQFEILSDQL-----------
N
I
-
S
I
P
V
F
S
I
H
G
N
H
D
D
P
T
G
A
D
A
LC
A
L
D
I
L
-
S
C
A
G
F
-
V
N
H
F
G
R
S
M
S
V
E
--
K
I
D
I
S
P
V
L
L
--
Q
--
K
G
S
T
K
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
----
Y
R
M
F
--
V
N
------------
K
K
V
T
M
L
R
P
-
K
E
D
-------
E
N
S
W
F
N
L
F
V
I
H
Q
N
R
S
K
--
H
G
---
S
T
---------
N
F
I
P
E
Q
F
L
D
D
F
I
D
L
V
I
W
G
H
E
H
E
C
K
I
A
-
P
T
-----
K
N
EQQL
F
Y
I
S
Q
P
G
S
S
V
V
T
S
L
S
P
GE
A
V
K
-
K
H
V
G
L
L
R
I
K
G
R
K
-----
M
N
M
H
K
I
P
L
H
T
V
R
Q
F
F
M
E
D
---
I
V
L
A
----------------------------------------------------------------------------------------------------------------------------
33
HHSearch
67.64
20%
32
- C1 -
-
3THO
-
RAD50_THEMA
B:
[1-377]
--
M
K
I
L
H
T
S
D
W
H
L
G
-
V
T
S
W
T
SSRP
V
D
R
R
E
E
L
K
K
A
L
D
K
V
V
E
E
A
E
K
R
E
V
D
L
I
L
L
T
G
D
L
L
H
S
R
N
N
P
S
V
V
A
L
H
D
L
L
D
Y
L
K
R
------------
M
M
--------------------------
R
--
T
A
P
V
V
V
L
P
G
N
Q
D
W
K
G
L
K
L
F
--
G
N
F
V
T
S
I
S
S
-
D
-
I
T
F
V
M
S
F
E
P
V
D
----------
V
E
A
K
--
R
G
-
Q
K
V
R
I
L
P
F
P
Y
P
D
E
S
--------
K
N
--
E
G
D
------
F
--
R
F
F
L
E
S
R
L
N
K
L
-
Y
E
E
----
A
L
K
K
E
D
F
A
I
F
M
G
H
F
T
V
E
G
--
L
A
G
-----------
R
E
I
I
I
N
R
A
L
I
P
S
V
V
D
Y
A
A
L
G
H
I
H
S
F
R
E
I
-
Q
K-----
Q
-----
P
L
T
I
Y
P
G
S
L
I
R
I
D
F
G
E
--
E
A
D
E
K
G
A
V
F
V
E
L
K
R
G
E
P
----
P
R
Y
E
R
I
D
A
S
P
-
L
P
L
K
T
L
Y
Y
KK
I
D
T
S
A
L
K
S
-
I
R
D
S
C
------
R
N
F
P
G
Y
V
R
V
V
Y
E
E
D
S
G
I
L
P
D
L
M
G
-
E
I
D
N
L
V
--------
K
I
E
R
K
S
R
R
E
I
E
E
V
LR
E
S
P
E
E
F
K
E
E
L
D
K
L
D
Y
F
E
L
F
K
E
Y
L
K
K
R
E
-
E
N
H
E
K
L
L
K
I
L
D
E
L
L
D
E
V
K
K
S
-------