@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTC7: (2017-12-12 )
MKILSIRIKNLASLADEHFIDFESAPLAHAGLIAIVGKTGAGKSTILDAMCLALFNRVPRLKDSDGKLKDVDGSELLTNSPLTVLRRGTGHGFAELCFIAQDQKRYLARWEIKRARENPNGKLQSVQRHLKCLTDGVVLADKAKAVDEKVKQITQLSFEQFTRAVLLAQSEVTAFLKARNSERGELLEYLTNSSIFAKIGELAFRKTADIAKQRKQLEEFLGHIEILSDEEIAAFTEQYQQAEQNYQQLEQQKHVLDKQQQWFERKAKLEQEVQAKQQLFQTQQNHHQQLASEREQLKRLEVFSEIRPQVFQQAQNLQTLQQLEPQIQQAQTKFNELVQIFETGQKQYQLAEQQLKQTIDFEQQHQHTLNQVRQSIQERAFIADEYKKCKEKRHVLEQKLSPLQQQQNAVQQQIAQLEQNKIHLQQQLIQTQQYAVLDKGLSAHLHQLGQFIQNYQAIEEQLGNPTFARQKLSEAKSELEQLTASLGTVEQIELKLEQQRKDKDQKLAQVTQLDLIQQKIKIYHELYAELQQFTEKHTQASAQEEQLKTVCQLAEQDYQTAKNEREKLQHILQQQRLLHTENIEQLRANLKEGEACLVCGSTHHPYRIDDSAVSKALFDLQQQQEQQAVALEQTKFNVWQTQQHALTQCRAELEQVQKYLAQLQAKQTNLQQELEQAFNLNQLHIELNQAPEQILQTLNELRQATQTAISLFDSENLRLTQAIKQHNQLIQTIQRNESLLNTAQQWQQQVQHIVECLSETEQHAWQQASSQTAKQTWAILDARAKQLEQQEQLSQRFEQQQQELKMLTASLEQMTKQIDEIDQNLQEITLKGQQNNEKAVSLIQQMTGRSDIKPHEWLIEHDAKRQHQQTAYHEAKQRFEQTRQHFEQQKQALDQLKHQHQHTEQHQQQIDGQIQNWLKAHTDFQASDLTALIQINSAQEQDIRNRLNHAERLLSEVSSALKTMQEQLSEHLQTQPDIEYEKLFTLIQDNIAKLKAQLEVRDGLKLKLELHQQNLAKQQKYAEQIQNIQQEEHRWSRISGLIGDAKGKEFRDYAQQYHLDILVEHANQQLAMLSQRYTLKRLDQSLSLAIIDHDMDGETRSVASLSGGESFLTALALSLAIANMASGSMKIESLFIDEGFGTLDASSLHMVMNALDQLQNQGRQVILISHIQEMHERIPVQIQVKPLGAGASTIEIVG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100......---.110.......120----..---.--.....130...------.-.-.--.--140.......150.......160.-----......170.......180.......190.......200.......210.-......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020.......1030......1040...-.--------..1050......1060......1070..-...---.1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190.....-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
I
L
S
I
R
I
K
N
L
A
S
L
A
D
E
HFIDFESAPLAHA
G
L
I
A
I
VGKTGA
G
K
S
T
I
L
D
A
M
C
L
A
L
F
NRVPRLKDSDGKLKDVDGSELLTNS
P
L
T
V
L
RRGTGH
G
F
A
E
L
C
F
I
AQ
D
Q
K
R
Y
L
A
---
R
W
E
I
K
R
ARENPNG-----
K
L
---
Q
--
S
V
Q
R
H
L
K
C
L
TD------
G
-
V
-
V
--L--A
D
K
A
K
A
V
D
E
K
V
K
Q
I
T
Q
L
S
F
E
Q
F
T
R
-----
A
V
L
L
A
Q
S
E
V
T
A
F
L
K
ARNS
E
R
G
E
L
L
E
Y
L
TN
S
S
I
F
A
K
I
G
E
L
A
F
R
K
T
A
D
I
A
K
Q
-
R
K
Q
L
E
E
F
L
G
H
I
EILS
D
E
E
I
A
A
F
T
E
Q
Y
Q
Q
A
E
Q
N
Y
Q
Q
L
E
Q
Q
K
H
V
L
D
K
Q
Q
Q
W
F
E
R
K
A
K
L
E
Q
E
V
Q
A
K
Q
Q
L
F
Q
T
Q
Q
N
H
H
Q
Q
L
A
S
E
R
E
Q
L
K
R
L
E
V
F
S
E
I
R
P
Q
V
F
Q
Q
A
Q
N
L
Q
T
L
Q
Q
L
E
P
Q
I
Q
Q
A
Q
T
K
F
N
E
L
V
Q
I
F
E
TG
Q
K
Q
Y
Q
L
A
E
Q
Q
L
K
Q
TI
D
F
E
Q
Q
H
Q
H
T
L
N
Q
V
R
Q
S
I
Q
E
R
A
F
I
A
D
E
Y
K
K
C
K
E
K
R
H
V
L
E
Q
K
L
S
P
L
Q
Q
Q
Q
N
A
V
Q
Q
Q
I
A
Q
L
E
Q
N
K
I
H
L
Q
Q
Q
L
I
Q
T
Q
Q
Y
A
V
L
D
K
G
L
S
A
H
L
H
Q
L
G
Q
F
I
Q
N
Y
Q
A
I
E
E
QLGN
P
T
F
A
R
Q
K
L
S
E
A
K
S
E
L
E
Q
L
T
A
S
LG
T
V
E
Q
I
E
L
K
L
E
Q
QRK
D
K
D
Q
K
L
A
Q
V
T
Q
L
D
L
I
Q
Q
K
I
K
I
Y
H
E
L
Y
A
E
L
Q
Q
F
T
E
K
HTQAS
A
Q
E
E
Q
L
K
T
V
C
Q
L
A
E
Q
D
Y
Q
T
A
K
N
E
R
E
K
L
Q
H
I
L
Q
Q
Q
RLL
H
T
E
N
I
E
Q
L
R
A
N
L
KEG
E
A
C
L
V
CGSTHH
P
Y
RI
D
D
S
A
V
S
K
A
L
F
D
L
Q
Q
Q
Q
E
Q
Q
A
V
A
L
E
QTKF
N
V
W
Q
T
Q
Q
H
A
L
T
Q
C
R
A
E
L
E
Q
V
Q
K
Y
L
A
Q
L
Q
A
K
Q
T
N
L
Q
Q
E
L
E
Q
AFNL
N
Q
L
H
I
ELNQ
A
P
E
Q
I
L
Q
T
L
N
E
L
R
Q
A
T
Q
T
A
I
S
LFDSEN
L
R
L
T
Q
A
I
K
Q
H
N
Q
L
I
Q
T
I
Q
R
N
E
S
L
L
N
T
A
Q
Q
W
Q
Q
Q
V
Q
H
I
V
E
C
L
S
E
T
E
Q
H
A
W
Q
Q
A
SS
Q
T
A
K
Q
T
W
A
I
L
D
A
R
A
K
Q
L
E
Q
Q
E
Q
L
S
Q
R
F
E
Q
Q
Q
Q
E
L
K
M
L
T
A
S
L
E
Q
M
T
K
Q
I
D
E
I
D
Q
N
L
Q
E
I
T
LKGQQN
N
E
K
A
V
S
L
I
Q
Q
M
TGRSDIK
P
H
E
W
L
I
E
H
D
A
K
R
Q
H
Q
Q
T
A
Y
H
E
A
K
Q
R
F
E
Q
T
R
Q
H
F
E
Q
Q
K
Q
A
L
D
Q
L
K
H
Q
H
Q
H
T
E
Q
H
Q
Q
Q
I
D
G
Q
I
Q
N
W
L
K
AHTDFQASD
L
T
A
L
I
Q
INS
A
Q
E
Q
D
I
R
N
R
L
N
H
A
E
R
L
L
S
E
V
S
S
A
L
K
T
M
Q
E
Q
L
S
E
H
LQTQPDI
E
Y
E
K
L
F
T
L
I
Q
D
N
I
A
K
L
K
A
Q
L
E
VRDG
L
K
L
K
L
E
L
H
Q
Q
N
L
A
K
Q
Q
K
Y
-
A
E
Q
I
Q
N
I
Q
Q
E
E
H
R
W
S
R
I
S
G
L
IGDAK-
G
--------
K
E
F
R
D
Y
A
Q
Q
Y
H
L
D
I
L
V
E
HA
N
Q
Q
L
A
M
L
S
Q
-
R
Y
T
---
L
K
R
L
D
QSL
S
L
A
I
I
DHDMDGET
R
S
V
A
SLSG
G
E
S
F
L
T
A
L
A
L
S
L
A
I
A
NMASG
S
M
K
I
E
S
L
F
IDEGFGTL
D
A
S
S
L
H
M
V
M
N
A
L
D
Q
L
Q
NQG
R
Q
V
I
L
I
S
H
I
Q
E
M
H
ERI
P
V
Q
I
Q
V
K
PLGAGA
S
T
I
E
IVG-
4
PsiBlast_PDB
65.66
24%
-79
- C1 -
-
3AUY
1
?
A:
[3-226]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
S
R
-
I
K
F
E
K
------
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
---------------
G
-
N
F
N
Y
D
---
T
I
I
T
K
G
K
K
S
V
Y
V
E
L
D
F
E
V
N
G
N
N
----------
Y
K
I
I
R
E
Y
D
S
G
-----
R
G
---
G
--
A
-----
K
L
Y
K
N
------
G
-
K
-
P
--
Y
--
A
T
T
I
S
A
V
N
K
A
V
N
E
I
L
G
V
D
R
N
M
F
L
N
-----
S
I
Y
I
K
Q
G
E
I
A
K
F
L
S
L
K
P
S
E
K
L
E
T
V
A
K
L
L
G
I
D
E
F
E
K
----
C
Y
Q
K
M
G
E
I
V
K
E
Y
E
K
R
L
E
R
I
E
G
E
L
N
-----
S
L
K
A
R
L
K
E
M
S
N
L
E
K
E
K
E
K
L
T
K
F
V
E
Y
L
D
K
V
R
R
I
F
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
62.44
24%
-78
- C1 -
-
5DNY
1
?
B:
[3-226]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
S
R
-
I
K
F
E
K
------
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
---------------
G
S
N
F
N
Y
D
---
T
I
I
T
K
G
K
K
S
V
Y
V
E
L
D
F
E
V
N
G
N
N
----------
Y
K
I
I
R
E
Y
D
S
G
-----
R
G
---
G
--
A
-----
K
L
Y
K
N
------
G
-
K
-
P
--
Y
--
A
T
T
I
S
A
V
N
K
A
V
N
E
I
L
G
V
D
R
N
M
F
L
N
-----
S
I
Y
I
K
Q
G
E
I
A
K
F
L
S
L
K
P
S
E
K
L
E
T
V
A
K
L
L
G
I
D
E
F
E
K
----
C
Y
Q
K
M
G
E
I
V
K
E
Y
E
K
R
L
E
R
I
E
G
E
-------------
K
E
M
S
N
L
E
K
E
K
E
K
L
T
K
F
V
E
Y
L
D
K
V
R
R
I
F
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
61.85
24%
-73
- C1 -
-
3AV0
3
RAD50_METJA
B:
[3-226]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
S
R
-
I
K
F
E
K
------
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
---------------
G
S
N
F
N
Y
D
---
T
I
I
T
K
G
K
K
S
V
Y
V
E
L
D
F
E
V
N
G
N
N
----------
Y
K
I
I
R
E
Y
D
S
G
-----
R
G
---
G
--
A
-----
K
L
Y
K
N
------
G
-
K
-
P
--
Y
--
A
T
T
I
S
A
V
N
K
A
V
N
E
I
L
G
V
D
R
N
M
F
L
N
-----
S
I
Y
I
K
Q
G
E
I
A
K
F
L
S
L
K
P
S
E
K
L
E
T
V
A
K
L
L
G
I
D
E
F
E
K
----
C
Y
Q
K
M
G
E
I
V
K
E
Y
E
K
R
L
E
R
I
E
G
E
L
N
-
Y
K
------
R
L
K
E
M
S
N
L
E
K
E
K
E
K
L
T
K
F
V
E
Y
L
D
K
V
R
R
I
F
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.30
24%
-76
- C1 -
-
5F3W
1
RAD50_METJA
B:
[3-227]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
S
R
-
I
K
F
E
K
------
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
---------------
G
S
N
F
N
Y
D
---
T
I
I
T
K
G
K
K
S
V
Y
V
E
L
D
F
E
V
N
G
N
N
----------
Y
K
I
I
R
E
Y
D
S
G
-----
R
G
---
G
--
A
-----
K
L
Y
K
N
------
G
-
K
-
P
--
Y
--
A
T
T
I
S
A
V
N
K
A
V
N
E
I
L
G
V
D
R
N
M
F
L
N
-----
S
I
Y
I
K
Q
G
E
I
A
K
F
L
S
L
K
P
S
E
K
L
E
T
V
A
K
L
L
G
I
D
E
F
E
K
----
C
Y
Q
K
M
G
E
I
V
K
E
Y
E
K
R
L
E
R
I
E
G
E
-------------
K
E
M
S
N
L
E
K
E
K
E
K
L
T
K
F
V
E
Y
L
D
K
V
R
R
I
F
G
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
59.68
28%
-133
- C1 -
-
3AUY
1
?
B:
[3-180]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
-
S
R
I
K
F
E
------
K
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
G
S
-
F
N
Y
D
--
T
------------
I
----
I
T
K
G
K
K
S
V
Y
V
E
L
D
F
E
V
N
G
-
N
N
Y
K
I
---
I
R
E
Y
D
S
G
R
----
G
-----
G
A
------------
K
L
Y
K
N
------
G
-
K
-
P
--
Y
--
A
T
T
I
S
A
V
N
K
A
V
N
E
I
L
G
V
D
R
N
M
F
L
N
-----
S
I
Y
I
K
Q
G
E
I
A
K
F
L
S
L
K
P
S
E
K
L
E
T
V
A
K
L
L
G
I
D
E
F
E
K
C
Y
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
59.16
28%
-134
- C1 -
-
3AUY
1
?
A:
[3-171]
M
I
L
K
E
I
R
M
N
N
F
K
S
H
V
N
-
S
R
I
K
F
E
------
K
G
I
V
A
I
I
G
E
N
G
S
G
K
S
S
I
F
E
A
V
F
F
A
L
F
G
A
G
-
N
F
N
Y
D
--
T
------------
I
----
I
T
K
G
K
K
S
V
Y
V
E
L
D
F
E
V
N
G
-
N
N
Y
K
I
---
I
R
E
Y
D
S
G
R
----
G
-----
G
A
------------
K
L
Y
K
N
------
G
-
K
-
P
--
Y
--
A
T
T
I
S
A
V
N
K
A
V
N
E
I
L
G
V
D
R
N
M
F
L
N
-----
S
I
Y
I
K
Q
G
E
I
A
K
F
L
S
L
K
P
S
E
K
L
E
T
V
A
K
L
L
G
I
D
E
F
E
K
C
Y
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
58.23
28%
-60
- C1 -
-
3QF7
1
RAD50_THEMA
B:
[1-175]
M
R
P
E
R
L
T
V
R
N
F
L
G
L
K
N
-
V
D
I
E
F
Q
------
S
G
I
T
V
V
E
G
P
N
G
A
G
K
S
S
L
F
E
A
I
S
F
A
L
F
G
N
G
I
R
Y
P
N
S
---
Y
D
------
Y
V
N
R
N
----
A
--
V
D
G
T
A
R
L
V
F
Q
F
E
R
-
G
G
K
R
Y
E
I
---
I
R
E
I
N
A
L
Q
R
K
H
N
A
-----
K
L
-----------
S
E
I
L
E
N
------
G
-
K
-
K
--
A
A
I
A
A
K
P
T
S
V
K
Q
E
V
E
K
I
L
G
I
E
H
R
T
F
I
R
-----
T
V
F
L
P
Q
G
E
I
D
K
L
L
I
S
P
P
S
E
I
T
E
I
I
S
D
V
F
Q
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
53.44
28%
-54
- C1 -
-
3QF7
1
RAD50_THEMA
A:
[1-171]
M
R
P
E
R
L
T
V
R
N
F
L
G
L
K
N
-
V
D
I
E
F
Q
------
S
G
I
T
V
V
E
G
P
N
G
A
G
K
S
S
L
F
E
A
I
S
F
A
L
F
G
N
G
I
R
Y
P
N
S
---
Y
D
------
Y
V
N
------
R
N
A
V
D
G
T
A
R
L
V
F
Q
F
E
-
R
G
G
K
R
Y
E
I
---
I
R
E
I
N
A
L
Q
R
K
H
N
A
-----
K
L
--------
S
E
---
I
L
E
N
------
G
-
K
-
K
A
A
I
--
A
A
K
P
T
S
V
K
Q
E
V
E
K
I
L
G
I
E
H
R
T
F
I
R
-----
T
V
F
L
P
Q
G
E
I
D
K
L
L
I
S
P
P
S
E
I
T
E
I
I
S
D
V
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
52.49
23%
-52
- C1 -
-
3QKT
2
A:
[153-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
V
-
V
R
E
V
L
N
L
D
K
F
E
T
A
Y
K
K
L
S
E
L
K
G
G
S
G
-
G
T
E
E
L
I
E
K
V
K
K
Y
K
A
L
A
R
E
A
A
L
S
K
I
G
E
L
A
S
E
I
F
A
E
F
T
E
G
K
Y
S
E
V
V
V
R
A
E
E
N
K
V
R
L
F
V
V
---
W
E
G
K
E
R
P
L
T
F
L
S
G
G
E
R
I
A
L
G
L
A
F
R
L
A
M
S
L
Y
L
A
G
E
I
S
L
--
L
I
L
D
E
P
T
P
Y
L
D
E
E
R
R
R
K
L
I
T
I
M
E
R
Y
L
K
K
I
P
Q
V
I
L
V
S
H
D
E
E
L
K
D
A
A
D
H
V
I
R
I
S
-
L
E
N
G
S
S
K
V
E
V
V
--
2
PsiBlast_PDB
52.22
30%
-147
- C1 -
-
3QF7
2
RAD50_THEMA
A:
[272-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
E
R
P
A
R
G
L
S
G
G
E
R
A
L
I
S
I
S
L
A
M
S
L
A
E
V
A
S
G
--
R
L
D
A
F
F
I
D
E
G
F
S
S
L
D
T
E
N
K
E
K
I
A
S
V
L
K
E
L
E
R
L
N
K
V
I
V
F
I
T
H
D
R
E
F
S
E
A
F
D
R
K
L
R
I
---------------
29
Fugue
52.14
16%
-17
* C1 *
-
1E69
-
?
A:
[1-1164]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
L
K
K
L
Y
L
K
G
F
K
S
F
G
R
P
S
L
I
G
F
S
D
R
V
T
A
I
V
G
P
N
G
S
G
K
S
N
I
I
D
A
I
K
W
V
F
G
E
K
F
D
M
I
F
A
G
S
E
N
L
P
P
A
G
S
A
Y
V
E
L
V
F
E
E
N
G
E
E
I
T
V
A
R
E
L
K
R
T
G
E
N
T
Y
Y
L
N
G
S
P
V
R
L
K
D
I
R
D
R
F
A
G
T
G
L
G
--------
V
D
F
Y
S
I
V
G
Q
G
Q
I
D
R
I
V
N
A
Y
Q
R
V
N
E
S
F
N
R
-
F
I
S
---
L
L
F
F
G
G
E
G
R
L
E
I
S
I
R
K
P
G
R
R
D
Q
K
L
S
L
L
S
G
G
E
K
A
L
V
G
L
A
L
L
F
A
L
M
E
I
K
P
S
P
----
F
Y
V
L
D
E
V
D
S
P
L
D
D
Y
N
A
E
R
F
K
R
L
L
K
E
N
S
K
H
-
T
Q
F
I
V
I
T
H
N
K
I
V
M
E
A
A
D
L
L
H
G
V
T
M
-
V
N
G
V
S
A
I
V
P
V
E
V
3
PsiBlast_PDB
51.17
30%
-171
- C1 -
-
4W9M
1
?
C:
[272-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
E
R
P
A
R
G
L
S
G
G
E
R
A
L
I
S
I
S
L
A
M
S
L
A
E
V
A
S
G
--
R
L
D
A
F
F
I
D
E
G
F
S
S
L
D
T
E
N
K
E
K
I
A
S
V
L
K
E
L
E
R
L
N
K
V
I
V
F
I
T
H
D
R
E
F
S
E
A
F
D
R
K
L
R
I
---------------
41
HHSearch
49.99
22%
-35
- C1 -
-
5H67
1
SMC_BACSU
A:
[1-184]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
I
S
V
D
F
V
------
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
E
Q
S
A
R
S
L
R
G
-
G
K
M
E
D
I
----
I
F
A
G
S
D
---
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
-
H
F
L
P
I
DFH
E
V
S
V
T
R
R
V
Y
-
R
S
G
-----
E
----------
S
-
E
-
F
L
I
N
------
N
-
Q
-
P
--
C
--
R
L
K
--
D
I
I
D
L
F
-
M
D
S
G
L
G
K
E
A
F
--------
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
49.89
28%
-151
- C1 -
-
3THO
1
RAD50_THEMA
A:
[289-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
E
R
P
A
R
G
L
S
G
G
E
R
A
L
I
S
I
S
L
A
M
S
L
A
E
V
A
S
G
--
R
L
D
A
F
F
I
D
E
G
F
S
S
L
C
T
E
N
K
E
K
I
A
S
V
L
K
E
L
E
R
L
N
K
V
I
V
F
I
T
C
D
R
E
F
S
E
A
F
D
R
K
L
R
I
---------------
38
HHSearch
49.65
23%
-84
- C1 -
-
1II8
-
RAD50_PYRFU
A:
[1-187]
M
K
L
E
R
V
T
V
K
N
F
R
S
H
S
D
-
T
V
V
E
F
K
------
E
G
I
N
L
I
I
G
Q
N
G
S
G
K
S
S
L
L
D
A
I
L
V
G
L
Y
W
P
L
R
I
-
K
D
I
--
K
K
D
-----
E
F
--------
T
K
V
G
A
R
D
T
Y
I
D
L
I
F
E
K
-
D
G
T
K
Y
R
I
---
T
R
R
F
L
K
G
Y
S
S
--
G
-----
E
I
---
H
------
A
M
K
R
L
V
G
------
N
E
W
K
H
--
V
T-
E
P
S
S
K
A
I
S
A
F
M
E
K
L
--
I
P
Y
N
I
F
L
N
-----
A
I
Y
I
R
Q
G
Q
I
D
A
I
L
E
-
S
D
E
A
R
E
K
V
V
R
E
V
L
N
L
D
K
F
E
T
A
Y
K
K
L
S
E
L
K
K
T
I
N
N
R
-
I
K
E
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
48.39
17%
-35
- C1 -
-
1QHL
-
MUKB_ECOLI
A:
[5-215]
G
K
F
R
S
L
T
L
I
N
W
N
G
F
F
A
-
R
T
F
D
L
D
------
E
L
V
T
T
L
S
G
G
N
G
A
G
K
S
T
T
M
A
A
F
V
T
A
L
I
P
D
L
T
L
L
-------------------
L
H
--
G
K
L
K
A
G
V
C
Y
S
M
L
D
T
I
N
S
R
--
H
Q
R
V
---
V
V
G
V
R
L
Q
Q
V
A
G
R
D
R
K
V
D
I
K
P
F
A
I
Q
GL
P
M
S
V
Q
P
T
Q
L
V
T
ETLNER
Q
-
A
-
R
--
V
---
L
P
L
N
E
L
K
D
K
L
E
A
M
E
G
V
Q
F
K
Q
F
N
S
I
T
D
Y
H
S
L
M
F
D
L
G
I
I
A
R
R
L
R
S
A
-
S
D
R
S
K
F
Y
-
R
L
I
E
A
S
L
Y
G
G
I
S
S
A
I
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Fugue
48.10
20%
-125
- C1 -
-
1F2U
1
?
A:
[1-149]
M
K
L
E
R
V
T
V
K
N
F
R
S
H
S
D
T
V
V
E
-------
F
K
E
G
I
N
L
I
I
G
Q
N
G
S
G
K
S
S
L
L
D
A
I
L
V
G
L
Y
W
P
L
R
I
K
D
I
K
K
D
E
F
----------------
T
K
V
G
A
R
D
T
Y
I
D
L
I
F
E
K
D
G
T
K
Y
R
I
T
---
R
R
F
L
K
G
Y
S
S
G
E
I
H
-----
A
M
---
K
--
R
L
V
G
N
----
E
W
------
K
-
H
-
V
--
T
--
E
P
S
S
K
A
I
S
A
F
M
E
K
L
--
I
P
Y
N
I
F
L
N
-----
A
I
Y
I
R
Q
G
Q
I
D
A
I
L
E
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
46.21
28%
-145
- C1 -
-
4YMS
-
?
J:
[127-194]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
--------
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
-----------------------------
40
HHSearch
45.78
22%
-38
- C1 -
-
5H66
-
?
A:
[1-184]
M
F
L
K
R
L
D
V
I
G
F
K
S
F
A
E
R
I
S
V
D
F
V
------
K
G
V
T
A
V
V
G
P
N
G
S
G
K
S
N
I
T
D
A
I
R
W
V
L
G
-------------
E
D
I
----
I
F
A
G
S
D
---
S
R
K
R
L
N
L
A
E
V
T
L
T
L
D
N
D
D
-
H
F
L
P
I
DFH
E
V
S
V
T
R
R
V
Y
-
R
S
G
-----
E
----------
S
-
E
-
F
L
I
N
------
N
-
Q
-
P
--
C
--
R
L
K
--
D
I
I
D
L
F
-
M
D
S
G
L
G
K
E
A
F
--------
S
I
I
S
Q
G
K
V
E
E
I
L
S
S
K
A
E
D
R
R
S
I
F
E
E
A
A
G
V
L
K
Y
K
T
R
K
K
K
A
E
N
K
L
F
E
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
45.40
21%
-
- C1 -
-
3QKS
-
RAD50_PYRFU
A:
[1-185]
M
K
L
E
R
V
T
V
K
N
F
R
S
H
S
D
-
T
V
V
E
F
K
------
E
G
I
N
L
I
I
G
Q
N
G
S
G
K
S
S
L
L
D
A
I
L
V
G
L
Y
W
P
L
R
I
K
D
-
I
--
K
K
D
-------------
E
F
T
K
V
G
A
R
D
T
Y
I
D
L
I
F
E
K
-
D
G
T
K
Y
R
I
---
T
R
R
F
L
K
G
Y
S
S
--
G
-----
E
I
---
H
------
A
M
K
R
L
V
G
------
N
E
W
K
H
--
V
T-
E
P
S
S
K
A
I
S
A
F
M
E
K
L
--
I
P
Y
N
I
F
L
N
-----
A
I
Y
I
R
Q
G
Q
I
D
A
I
L
E
-
S
D
E
A
R
E
K
V
V
R
E
V
L
N
L
D
K
F
E
T
A
Y
K
K
L
S
E
L
K
K
T
I
N
N
R
-
I
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------