@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTD6: (2017-12-13 )
MQTLIFMHETGKISIDFFKECIMQDIPMSRWLSPLMAFCLSFVIMATLAPTMGIQIDRQIDFWLLWFGTMLLLALPVCYLEIALAKRSKTTALNALSSLTREADSSPKWRVVGCLAVVFIPFLAGNVLSTASNILVAQFAPSISSQIIFVGLAVAALVLSFIPRQILILLMTLGVIASIVLANMMGSTLQPWHWTSVEFKEWGNATVLALVASGLGLGLYWQNSVGAVQAQEGATKTVLPIWLAQLIAVVAFGFFSLQAQLPVLTWIFTGVMTSALFVQLAREQLAQRQLMPVLQWVIIVVAIAVWAVPEVHNLFTLILMQWGLLICLIYAVFAGWIMKISHLRKSMNFSNELFYNLWRIAVRIVLPLSIIVAMIAVIGQSI
Atome Classification :
(20 SA)
---.........10.----.......20........30........40........50......--..60...------...-----..70........80......--------..90........100-........--.110.......---120..------------------.--------------....---130-----------------------.------------------------------..--------.------------....----------.--------140-..--.------..-------.-----.-----.-------.150......----.----160--..-----.--.....170.......180...-.------.-----..190.....-.-.200.......210..--....---.220..----------......-230.......240......--------.--------250.-----------------.-...---------------------------------.-------.260....---------.---------..270......--------.280....----...290.---...--....300.......--310---------.----------------.------.....-320-----.--..----.-.....330.......340.......350.-...----....360....---..-----.370.......380-----------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---M
Q
T
L
I
F
M
HET
G
K
----
I
S
I
D
F
F
K
E
C
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M
QDI
P
M
S
R
W
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L
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LAPTM
G
I
Q
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D--RQI
D
F
W
L
------
L
W
F
-----
G
T
M
L
L
L
A
L
P
V
C
Y
L
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A
L
AKR--------S
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N
A
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L
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---
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A
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-
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P
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L
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---------
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----------------
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----
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V
A
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V
IGQSI-----------------
17
Fugue
85.23
20%
-141
* C6 *
-
4US3
11
?
A:
[10-450]
-------------
G
R
--------------
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L
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-
D
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---------------------------------
R
L
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R
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N
----------------
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------
F
D
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-------
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--
A
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F
L
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G
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R
F
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---
P
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-----
A
I
L
I
V
F
L
S
A
F
---------------------
22
Fugue
74.28
18%
-
- C- -
-
4W7G
-
?
A:
[44-394]
R
L
P
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K
N
I
I
L
L
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----
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-----
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--------------
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---
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------------------------------------------------------------------------------------------------------------------------------------------
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-------
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----
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------
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-----
P
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--------
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--
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---
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-
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----------
T
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-
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D
V
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L
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L
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G
A
--------
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--------
L
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Y
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-----------------
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-
P
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V
---------------------------------
P
-------
S
Q
L
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L
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---------
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---------
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Q
--------
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---
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--
W
--------------------------------------------------------------------------------------
D
S
W
G
K
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L
R
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--
G
F
D
V
-
E
-
R
V
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----
N
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D
L
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P
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---
P
L
PDPEG
S
T
V
V
L
Y
E
E
A
V
Q
D
P
T
-----------------
12
HHSearch
73.19
15%
-152
- C6 -
-
4US3
11
?
A:
[35-450]
-----------------------------------------------------
W
R
F
S
Y
V
-
T
G
E
N
--
G
G
A
A
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L
L
------
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Y
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-----
G
F
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---------
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A
---
G
F
L
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L
------------------
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F
Y
G
V
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G
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N
Y
I
T
GQL
W
-------------------------
S
APAEG
F
------------------------
G
G
--------
F
------------
F
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G
F
I
---------
A
--------
N
---
P
T
L
P
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------
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-------
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-----
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-----
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-------
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M
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A
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W
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A
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K
----
G
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---
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--
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G
------
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--------
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--------
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-----------------
I
-
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GLSPSGGPG
L
V
F
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V
L
P
D
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A
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L
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----
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----
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L
S
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I
------
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-------
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----
L
P
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G
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G
W
G
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---
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-----
A
I
L
I
V
F
L
S
A
F
---------------------
25
Fugue
69.20
18%
-205
- C2 -
-
4TQ3
1
?
A:
[15-301]
---
S
K
Y
L
R
L
L
R
-----------------------
P
V
A
W
L
C
F
L
L
P
Y
A
V
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F
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F
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A
L
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--------------------------
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---
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R
---------------------------
F
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A
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G
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P
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A
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P
A
A
F
--------
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L
A
A
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-
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P
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-------
A
V
S
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L
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----
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A
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F
A
V
I
S
V
------------------------
7
HHSearch
63.94
15%
-164
- C6 -
-
5I6X
4
SC6A4_HUMAN
A:
[30-484]
-----------------------------------------------------
W
R
F
P
Y
I
C
A
Q
-
N
--
G
G
G
A
F
L
L
------
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-----
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M
A
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G
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C
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---
A
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A
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A
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Y
Y
L
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F
T
--------------
D
Q
L
P
---
W
-------------------------
T
SCKNSWNTGN
C
T
N
Y
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I
T
W
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LHSTS
P
A
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--------
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------------
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T
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--------
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L
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A
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L
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L
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--------
F
V
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G
-----------------
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V
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G
L
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A
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L
--------
E
G
V
I
T
A
V
L
----
D
E
F
P
-
H
V
WAK
R
R
E
--
R
F
V
L
A
V
V
I
T
C
F
F
G
S
--
L
V
T
---------
L
----------------
T
FG
G
A
Y
V
V
K
L
L
E
E
Y
-------
A
TG
P
A
----
V
L
T
V
A
L
I
E
A
V
A
V
S
W
F
Y
G
I
T
Q
F
C
R
D
V
K
E
M
L
G
F
-
S
P
G
----
W
F
W
R
I
C
W
V
A
I
S
---
P
L
-----
F
L
L
F
I
I
A
S
F
L
---------------------
8
HHSearch
63.58
15%
-163
- C6 -
-
5I6Z
1
SC6A4_HUMAN
A:
[30-484]
-----------------------------------------------------
W
R
F
P
Y
I
C
Y
Q
-
N
--
G
G
G
A
F
L
L
------
P
Y
T
-----
I
M
A
I
F
G
G
I
P
L
F
Y
M
E
L
A
L
G
Q
Y
--------
H
R
N
G
C
I
S
I
W
R
K
I
---------
C
P
I
--
F
K
G
I
G
Y
A
I
C
I
I
---
A
F
Y
I
A
S
Y
Y
N
T
I
M
A
W
A
L
Y
Y
L
I
S
S
F
T
--------------
D
Q
L
P
---
W
-------------------------
T
SCKNSWNTGN
C
T
N
Y
FSEDN
I
T
W
T
LHSTS
P
A
E
E
--------
F
------------
Y
T
R
H
VLQIHRSKGL
Q
--------
D
---
L
G
G-
I
------
S
W
-------
Q
-----
L
A
L
C
I
M
L
-------
I
F
T
V
I
Y
F
S
I
W
----
K
----
G
V
---
K
T
S
G
---
K
V
V
W
V
T
A
T
F
P
Y
I
A
L
S
V
L
L
V
R
G
A
T
L
P
G
------
A
W
R
G
V
L
F
Y
L
K
P
N
W
Q
K
L
L
E
-
T
G
V
W
I
D
A
A
A
Q
I
F
F
S
L
G
--
P
G
F
G
---
V
L
L
A
F
A
----------
S
Y
N
--
K
-
F
N
N
N
C
Y
Q
D
A
L
V
T
S
V
V
N
C
M
T
--------
S
--------
F
V
S
G
-----------------
F
-
V
I
F
T
V
L
G
Y
M
A
E
M
R
NED
V
S
E
V
A
KDAGPSLLFI
T
Y
A
E
A
I
-------
A
N
M
P
A
S
T
F
---------
F
A
I
I
F
F
L
M
L
I
T
L
G
L
D
S
S
F
A
G
L
--------
E
G
V
I
T
A
V
L
----
D
E
F
P
-
H
V
WAK
R
R
E
--
R
F
V
L
A
V
V
I
T
C
F
F
G
S
--
L
V
T
---------
L
----------------
T
FG
G
A
Y
V
V
K
L
L
E
E
Y
-------
A
TG
P
A
----
V
L
T
V
A
L
I
E
A
V
A
V
S
W
F
Y
G
I
T
Q
F
C
R
D
V
K
E
M
L
G
F
-
S
P
G
----
W
F
W
R
I
C
W
V
A
I
S
---
P
L
-----
F
L
L
F
I
I
A
S
F
L
---------------------
10
HHSearch
60.84
15%
-144
- C6 -
-
4XP9
7
DAT_DROME
C:
[27-474]
-----------------------------------------------------
W
R
F
P
Y
L
C
Y
K
-
N
--
G
G
G
A
F
L
V
------
P
Y
G
-----
I
M
L
A
V
G
G
I
P
L
F
Y
M
E
L
A
L
G
Q
H
--------
N
R
K
G
A
I
T
C
W
G
R
L
---------
V
P
L
--
F
K
G
I
G
Y
A
V
V
L
I
---
A
F
Y
V
D
FYYNVIIAWSLRFFFASF
T
--------------
N
S
L
P
---
W
TSCNNIWNTPNCRPFEGHVEGFQSA
A
------------------------------
S
E
--------
Y
------------
F
N
R
Y
ILEL------
N
RSEGIH--
D
---
L
G
A-
I
------
K
W
-------
D
MALCL
L
-----
I
-------
V
Y
L
I
C
Y
F
S
L
W
----
K
----
G
I
---
S
T
SG---
K
VV
W
F
T
A
L
F
P
Y
A
V
L
L
I
L
L
I
R
G
L
T
L
P
G
------
S
FLGIQ
Y
Y
L
T
P
N
F
S
A
I
Y
K
-
A
E
V
W
V
D
A
A
T
Q
V
F
F
S
L
G
--
P
G
F
G
---
V
L
L
A
Y
A
----------
S
Y
N
--
K
-
Y
H
N
N
V
Y
K
D
A
L
L
T
S
F
I
N
S
A
T
--------
S
--------
F
I
A
G
-----------------
F
-
V
I
F
SVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA-
I
-------
A
T
M
P
A
S
T
F
---------
W
ALIFFMMLA
T
L
G
L
D
S
S
F
G
G
S
--------
E
A
I
I
T
A
L
S
----
D
E
F
P
-
K
I
---
K
R
N
RE
L
F
V
A
G
L
F
S
L
Y
F
V
V
G
--
L
A
S
---------
C
----------------
T
QGGFYF
F
H
L
L
D
R
Y
-------
A
AG
Y
S
----
I
L
V
A
V
F
F
E
A
I
A
V
S
W
I
Y
G
T
N
R
F
S
E
D
I
R
D
M
I
G
F
-
P
P
G
----
R
Y
W
Q
V
C
W
R
F
V
A
---
P
I
-----
F
L
L
F
I
T
V
Y
G
L
---------------------
9
HHSearch
60.41
15%
-144
- C6 -
-
4XP1
8
DAT_DROME
A:
[27-474]
-----------------------------------------------------
W
R
F
P
Y
L
C
Y
K
-
N
--
G
G
G
A
F
L
V
------
P
Y
G
-----
I
M
L
A
V
G
G
I
P
L
F
Y
M
E
L
A
L
G
Q
H
--------
N
R
K
G
A
I
T
C
W
G
R
L
---------
V
P
L
--
F
K
G
I
G
Y
A
V
V
L
I
---
A
F
Y
V
D
F
Y
Y
N
V
I
I
A
W
S
L
R
F
F
F
A
S
F
T
--------------
N
S
L
P
---
W
TSCNNIWNTPNCRPFEGHVEGFQS
A
A
------------------------------
S
E
--------
Y
------------
F
N
R
Y
IL--------
E
LNRSEGIH
D
---
L
G
A-
I
------
K
W
-------
D
M
A
L
C
L
L
-----
I
-------
V
Y
L
I
C
Y
F
S
L
W
----
K
----
G
I
---
S
T
S
G
---
K
V
V
W
F
T
A
L
F
P
Y
A
V
L
L
I
L
L
I
R
G
L
T
L
P
G
------
S
F
L
G
I
Q
Y
Y
L
T
P
N
F
S
A
I
Y
K
-
A
E
V
W
V
D
A
A
T
Q
V
F
F
S
L
G
--
P
G
F
G
---
V
L
L
A
Y
A
----------
S
Y
N
--
K
-
Y
H
N
N
V
Y
K
D
A
L
L
T
S
F
I
N
S
A
T
--------
S
--------
F
I
A
G
-----------------
F
-
V
I
F
S
V
L
G
Y
M
A
H
TLGVRIEDVATEGPGLVFV
V
Y
P
A
A
-
I
-------
A
T
M
P
A
S
T
F
W
A
L
I
F
F
M
M
L
A
---------
T
L
G
L
D
S
S
F
G
G
S
--------
E
A
I
I
T
A
L
S
----
D
E
F
P
-
K
I
---
K
R
N
R
E
L
F
V
A
G
L
F
S
L
Y
F
V
V
G
--
L
A
S
---------
C
----------------
T
QG
G
F
Y
F
F
H
L
L
D
R
Y
-------
A
AG
Y
S
----
I
L
V
A
V
F
F
E
A
I
A
V
S
W
I
Y
G
T
N
R
F
S
E
D
I
R
D
M
I
G
F
-
P
P
G
----
R
Y
W
Q
V
C
W
R
F
V
A
---
P
I
-----
F
L
L
F
I
T
V
Y
G
L
---------------------
18
Fugue
57.31
16%
-81
* C4 *
-
4UZ1
1
NOTUM_HUMAN
A:
[9-375]
-----------------------------
N
E
D
L
R
L
H
L
L
L
N
T
S
V
T
-
C
N
D
-------
G
S
P
A
G
Y
Y
L
K
E
S
R
G
S
R
R
W
L
------
L
F
L
E
----
G
G
W
Y
C
F
N
R
E
N
C
D
S
R
Y
D
T
M
R
R
LMSSRDWP
R
T
R
T
G
T
G
I
L
S
S
------
Q
P
E
E
N
P
Y
--
W
W
N
A
---
N
M
V
F
---
I
P
Y
C
S
------------------
S
--------------
D
V
W
S
---
G
-------------------------
A
------------------------------
S
S
K
S
EKNEYA
F
------------
M
G
A
L
----------
I
--------
I
---
Q
E
--
V
------
V
R
-------
E
-----
L
-----
L
-------
G
R
G
L
S
G
A
------------------------
K
--
V
L
L
L
A
G
S
S
A
G
G
T
G
V
L
L
N
V
D
R
V
-
A
------
E
-----
Q
L
E
K
L
G
Y
P
A
I
----------
Q
V
R
G
L
A
D
S
G
--
W
F
L
D
NKQ
Y
R
H
-
T
D
----------
C
V
D
T
I
T
C
A
P
T
E
A
I
R
R
G
I
R
Y
W
N
G
V
V
P
E
--------
R
--------
C
R
R
Q
-----------------
F
-
Q
E
G
---------------------------------
E
-------
E
W
N
C
F
F
G
Y
---------
K
---------
V
Y
P
T
L
R
S
P
V
F
V
V
Q
W
LFD
E
A
Q
L
T
V
D
N
V
H
----
L
P
V
Q
-
E
G
---
L
R
L
--
Y
I
Q
N
L
G
R
E
L
R
H
T
L
K
--
D
V
P
---------
A
----------------
S
------
F
A
P
A
C
-
L
-------
S
--
H
E
----
I
-
I
I
R
------
S
H
W
--------
T
D
V
Q
V
K
G
-
T
-
S
L
P
----
R
A
L
H
C
W
D
R
S
L
H
---
K
T
-----
P
L
K
G
C
P
V
H
L
V
D
S
C
P
WPHCNPSCPTG------
13
HHSearch
55.69
12%
-103
- C6 -
-
2A65
6
?
A:
[29-471]
-----------------------------------------------------
L
R
F
P
V
Q
A
-
A
E
N
--
G
G
G
A
F
M
I
------
P
Y
I
-----
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
--------
G
G
A
Q
G
H
G
T
T
P
A
I
F
---
Y
L
L
W
R
N
R
F
--
A
K
I
L
G
V
F
G
L
W
I
---
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
G
F
A
I
K
F
L
V
--------------
G
L
V
P
---
E
-------------------------
P
PPTD
P
D
S
I
L
R
P
F
------------------
K
E
--------
F
------------
L
Y
S
Y
I
GV-------
P
--------
K
GD-
E
P
I
-
L
------
K
P
-------
S
-----
L
-----
F
A
Y
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
----
R
GISK
G
I
---
E
R
F
----
A
--
K
I
A
M
P
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
PNGT--
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
K
D
-
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
--
L
G
F
G
---
A
I
I
T
Y
A
----------
S
Y
V
--
R
-
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
--------
E
VI
L
G
G
S
I
S
I
P
A
A
-----------------
V
-
A
F
F
G
V
A
N
A
V
A
I
A
K
AGAFNLGFI
T
L
P
A
I
---------
F
-------
S
Q
T
A
G
G
T
F
---------
L
G
F
L
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
--------
Q
P
M
I
A
F
L
E
----
D
E
L
K
-
L
S
---
R
K
H
--
A
V
L
W
T
A
A
I
V
F
F
S
A
H
--
L
V
M
---------
F
LNK-------------
S
------
L
D
E
M
D
F
W
-------
A
GT
I
G
----
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
R
G
G
I
I
-
K
V
P
----
R
I
Y
Y
Y
V
M
R
Y
I
T
---
P
A
-----
F
L
A
V
L
L
V
V
W
A
R
E
Y
------------------
11
HHSearch
55.31
13%
-109
- C6 -
-
2QJU
6
?
A:
[25-466]
-----------------------------------------------------
L
R
F
P
V
Q
A
A
-
E
N
--
G
G
G
A
F
M
I
------
P
Y
I
-----
I
A
F
L
L
V
G
I
P
L
M
W
I
E
W
A
M
G
R
Y
--------
G
G
A
Q
G
H
G
T
T
P
A
I
F
---
Y
L
L
W
R
N
R
F
--
A
K
I
L
G
V
F
G
L
W
I
---
P
L
V
V
A
I
Y
Y
V
Y
I
E
S
W
T
L
G
F
A
I
K
F
L
V
--------------
G
L
V
P
---
E
-------------------------
P
P
PTD
P
D
S
I
L
R
P
F
------------------
K
E
--------
F
------------
L
Y
S
Y
I
GV-------
P
--------
K
GDE
P
I
--
L
------
K
P
-------
S
-----
L
-----
F
A
Y
I
V
F
L
I
T
M
F
I
N
V
S
I
L
I
----
R
----
G
I
---
S
K
G
I
E
R
F
A
--
K
I
A
M
P
T
L
F
I
L
A
V
F
L
V
I
R
V
F
L
L
E
T
PNGT--
A
A
D
G
L
N
F
L
W
T
P
D
F
E
K
L
K
D
-
P
G
V
W
I
A
A
V
G
Q
I
F
F
T
L
S
--
L
G
F
G
---
A
I
I
T
Y
A
----------
S
Y
V
--
R
-
K
D
Q
D
I
V
L
S
G
L
T
A
A
T
L
N
E
K
A
E
VI
L
G
G
S
I
S
--------
I
P
A
A
-----------------
V
-
A
F
F
G
V
A
N
A
V
A
I
A
K
A
GAFNLGFI
T
L
P
A
I
---------
F
-------
S
Q
T
A
G
G
T
F
---------
L
G
F
L
W
F
F
L
L
F
F
A
G
L
T
S
S
I
A
I
M
--------
Q
P
M
I
A
F
L
E
----
D
E
L
K
-
L
S
---
R
K
H
--
A
V
L
W
T
A
A
I
V
F
F
S
A
H
--
L
V
M
---------
F
LNK-------------
S
------
L
D
E
M
D
F
W
-------
A
GT
I
G
----
V
V
F
F
G
L
T
E
L
I
I
F
F
W
I
F
G
A
D
K
A
W
E
E
I
N
R
G
G
-
I
I
K
V
P
----
R
I
Y
Y
Y
V
M
R
Y
I
T
---
P
A
-----
F
L
A
V
L
L
V
V
W
A
R
E
-------------------
2
PsiBlast_PDB
42.77
25%
-212
- C5 -
-
4US4
-
?
A:
[397-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
-
S
-
V
W
G
----
K
L
W
I
L
S
L
R
F
I
A
---
P
I
-----
A
I
L
I
V
F
L
S
-----------------------
3
PsiBlast_PDB
42.62
24%
-84
- C1 -
-
4KI5
-
?
F:
[27-150]
------------------------------------------------------------------
Q
E
I
S
G
Y
L
------
S
W
L
QQKPD
G
T
I
K
R
L
I
Y
A
A
S
T
L
D
S
S
V
P
K
R
--------
F
S
G
S
R
S
G
S
D
Y
S
L
T
---
I
S
-
L
D
S
E
D
--
F
A
V
Y
Y
C
L
Q
Y
A
S
---
Y
P
Y
T
F
------------------
G
--------------
G
--
G
---
T
-------------------------
K
------------------------------
V
E
--------
I
------------
K
R
A
D
----------
A
--------
A
---
P
T
--
V
SIFPPS
S
E
-------
Q
-----
L
-----
T
-------
S
G
G
A
S
V
V
C
F
L
----
N
----
N
F
---
Y
P
-----
K
--
D
I
N
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Fugue
41.74
10%
-127
- C3 -
-
2B78
-
?
A:
[1-385]
---
M
I
K
L
M
V
G
S
F
A
E
K
----
K
L
K
R
G
V
Q
L
L
S
S
R
D
Y
P
N
L
N
L
D
N
------
Q
V
V
Q
L
Y
S
D
A
D
I
F
L
G
T
A
Y
L
--
S
K
Q
N
K
G
V
------
G
W
L
-----
I
S
P
K
K
V
S
L
N
V
T
Y
F
I
K
L
F
Q
W
S
--------
K
D
------
K
R
K
N
F
---
A
H
S
K
L
T
T
A
--
Y
R
L
F
N
Q
D
G
D
-------
S
F
G
------------------
G
--------------
V
T
I
D
---
C
-------------------------
Y
------------------------------
G
D
--------
F
------------
V
L
F
S
----------
W
--------
Y
---
N
-------------------------------------------
S
F
V
Y
Q
I
----
R
----
D
E
---
I
V
-----
A
--
A
F
R
Q
V
Y
P
N
F
L
G
A
Y
E
K
I
R
F
N
V
S
-
A
------
H
-----
L
Y
G
Q
E
A
P
E
Q
F
-
L
-
I
L
E
-
N
G
I
S
Y
N
V
F
L
N
D
G
LM
T
G
I
F
---
L
D
Q
-
R
Q
----------
V
R
N
E
L
I
-
N
G
S
A
A
G
K
T
V
L
N
L
F
-----------------------
S
Y
T
A
-----------------
A
-
F
S
V
---------------------------------
A
-------
A
A
M
G
G
A
M
----------
A
---------
T
T
S
V
D
L
A
K
R
S
R
--------
A
L
S
L
A
H
F
E
----
A
N
H
L
D
M
A
---
N
H
Q
--
L
V
V
M
D
V
F
D
Y
F
K
Y
A
R
--
R
H
H
---------
L
----------------
T
------
Y
D
I
I
I
-
I
D
P
P
SFEV
F
--
S
V
----
S
-
K
D
Y
H
K
L
I
R
Q
G
L
E
I
L
S
E
N
G
L
I
I
A
S
T
N
A
A
-
N
-
M
T
V
----
S
Q
F
K
K
Q
I
E
K
G
F
GKQ
K
H
-----
T
Y
L
D
L
Q
Q
L
P
S
D
F
A
V
NVQDESSNY
L
K
V
F
T
I
K
V
1
PsiBlast_PDB
40.55
25%
-205
- C5 -
-
4US3
1
?
A:
[397-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
M
I
I
A
L
F
I
G
W
G
W
K
T
S
D
A
L
A
E
S
D
L
T
D
-
S
-
V
W
G
----
K
L
W
I
L
S
L
R
F
I
A
---
P
I
-----
A
I
L
I
V
F
L
S
-----------------------
5
PsiBlast_PDB
39.98
27%
-360
- C5 -
-
4EV6
1
CORA_METJA
A:
[248-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
I
D
M
S
A
---------
T
---------
Y
R
E
V
L
T
S
M
M
D
I
--------
T
L
S
L
E
N
I
K
----
M
N
Q
I
-
M
K
---
I
L
T
--
M
V
T
T
I
F
A
V
P
M
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------
21
Fugue
32.68
21%
-16
- C6 -
-
4HR6
-
?
A:
[1-41]
---------------------------------------------------------------------------------------------------
A
N
L
R
L
S
E
A
--------
N
S
G
T
Y
K
T
F
I
G
R
V
R
---
E
E
L
-
G
S
E
T
--
Y
R
L
Y
G
---------
I
P
V
L
K
------------------
H
--------------
S
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
Fugue
27.41
10%
-
- C4 -
-
3TW8
-
DEN1B_HUMAN
A:
[2-374]
---
M
D
C
R
T
K
A
N
P
D
R
T
FD
L
V
L
K
V
K
C
E
D
P
V
V
L
W
K
F
P
E
D
F
G
D
Q
E
I
L
Q
S
V
P
K
F
C
F
P
F
D
V
E
R
V
S
Q
N
Q
V
G
--
Q
H
F
T
F
V
L
T
D
IES
K
Q
R
F
-----
G
F
C
R
L
T
S
G
G
T
I
C
L
C
I
L
S
Y
L
P
--------
W
F
E
V
Y
Y
K
L
L
N
T
L
A
---
D
Y
L
A
K
E
L
E
--
N
D
L
N
E
T
L
R
S
L
Y
N
HP
V
P
K
A
N
------------------
T
--------------
G
L
P
T
---
I
-------------------------
P
------------------------------
E
S
--------
R
------------
N
L
T
E
----------
Y
--------
F
---
V
A
--
V
------
D
V
-------
N
-----
N
-----
M
-------
L
Q
L
Y
A
S
M
-------------
L
---
H
E
-----
R
--
R
I
V
I
I
S
S
K
L
S
T
L
T
A
C
I
H
G
S
A
A
--------------
L
L
Y
P
M
Y
W
Q
-----------------------------------------------------------
H
I
Y
I
P
V
L
P
P
H
L
L
D
--------
Y
--------
C
C
A
P
-----------------
M
P
Y
L
I
---------------------------------
G
-------
I
H
S
S
L
I
E
R
---------
V
---------
K
N
K
S
L
E
D
V
V
M
L
--------
N
V
D
T
N
T
L
E
----
S
P
F
-----------------
S
D
L
N
N
L
P
S
D
--
V
V
S
---------
A
----------------
L
------
K
N
K
L
K
-
K
-------
Q
--
S
T
----
A
-
T
G
D
G
V
A
R
A
F
L
R
A
Q
A
A
L
F
G
S
Y
R
D
I
T
F
C
E
-
E
-
S
F
V
KHRS
S
V
M
K
Q
F
L
E
T
A
I
---
N
L
-----
Q
L
F
K
Q
F
I
D
G
R
L
A
K
L
N----------------
4
PsiBlast_PDB
23.72
45%
-108
- C5 -
-
5GJ7
-
?
A:
[236-264]
-----------------------------------------------------------
G
V
Q
A
E
--
R
R
P
D
-----------------
G
S
G
W
L
L
H
I
P
A
C
Y
L
G
I
A
L
A
A
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
20.70
30%
122
* C5 *
-
2C5I
-
VPS51_YEAST
P:
[7-29]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
S
L
R
V
S
S
L
N
K
D
R
R
L
L
L
-
R
-
E
F
Y
----
N
L
--------------------------------------------------