@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTF5: (2017-12-13 )
MTAVSSVYAQRLLMTLFLASFGIYMFLATVTYTPFDPGWMHISSDTQQVSNASGIAGAWIADLLFGFLGWASLLIPIFLFVEAIQVWWPHSFLNRPFRYAAQFFLILVVSSLLYLHWNVPADTLDNAAGGIIGYELGQSLSQLLTIYGATLFLLVFGVVLFTLAFGVQWSKTWVTLKAMPGYLQDLFYKNVSPNESAYDLTTQPANKAATVKVAEMPKAEEVTDEVELNAQPEKAQSKASSTRHDEIAERLFADVLAKEQSQPETIEEKPTPQPENFERTLEQAQQLKKDSERLVATGEVWRALQRDDVSHKQEIDALLRAADDSSEQPSTHEQFQQTVYQAKQNQPSNTHQGLDWNDDEIFDELLAAVPNSRTATDVHTPFVQDHHVEPEVTPQAPQTLVESSVPVSNLNQSPKNLSNEEVFDDFDDLLIDEDIPPATQPIKASSYAQSSAFVKAPIQTSIGAEKLSKEEFIEAWQETAGKPQDDLEDEFDFDAPLTDASGRPMSRAMQVAKKRLDLPTLPGFELLDKVDPNKKVNFTEEQLSRLSELLEIKLQEFNVKAQVVEAQPGPVVTRFELDLAPGVKASKVTNISRDLARSMSMASVRVVEVIPGKPYIGIEVPNSAREMVRLIELLETPAYRDPSALISMAMGKDISGNPVLTDLAKAPHMLVAGTTGSGKSVAVNSMILSMLLKYTPDQLRLILIDPKQLELANYNDIPHLLTPVVTDMKDAVSALNWCVNEMERRYKLMSFLKIRKLSDYNRKVEEALANGEDLIDPTWKPSDSATQERAPRLMPLPSIVIVADEFADMIMQVGKKAEEMITRLAQKSRAAGIHLLLATQRPSVDVITGLIKANIPTRVALRVNSKIDSRTILDAGGAEDLLGHGDMLFLGPGKIEPERVHGAFISDDEVNRICDAWRERGEPDYVDEILTPFDEEPASRGFEEGDGGSDRDALYDQCVSFVLETRKASTSSLQRKFSLGYNRAARIIDQMEENGIVSAMGANGKRDILV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650....--...660.......670.......680.......690.......700.......710.......720..-.....730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840...-....850.......860.......870.....--..880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MT
A
V
S
S
V
Y
A
Q
R
L
L
M
T
L
F
L
A
S
F
G
I
Y
M
F
L
A
T
V
TYTPFDPG
W
M
H
ISS
D
T
Q
Q
VSNASG
I
A
G
A
W
I
A
D
L
L
F
G
F
L
G
W
A
S
L
L
I
P
I
F
L
F
V
E
A
I
Q
V
WW
P
H
S
F
LN
R
P
F
R
Y
A
A
Q
F
F
L
I
L
V
V
S
S
L
L
Y
LHWNV
P
A
D
T
LDNAAG
G
I
I
G
Y
E
L
G
Q
S
L
S
Q
L
L
T
I
Y
G
A
T
L
F
L
L
V
F
G
V
V
L
F
T
L
A
FGV
Q
W
S
K
T
W
V
T
L
KAM
P
G
Y
L
Q
D
L
F
YKNVSPNESAYDLTTQPANK
A
A
T
V
K
V
AEMP
K
A
E
E
VT
D
E
VELNAQ
P
E
K
A
Q
SKASST
R
H
D
E
I
A
E
R
L
F
A
D
V
L
A
KEQSQPETIEEKPTPQ
P
E
N
F
E
R
T
L
E
Q
A
Q
Q
L
K
K
D
S
E
R
L
V
A
T
G
E
V
W
R
A
L
Q
RDDV
S
H
K
Q
E
I
D
A
L
L
RAADDSSEQP
S
T
H
E
Q
F
Q
Q
T
V
Y
Q
A
KQNQPSNTHQGLDW
N
D
D
E
I
F
D
E
L
L
A
AVPNSRTATDVHTPFVQDHHVEPEVTPQA
P
Q
T
L
V
ESSVPVSNLNQSPKNLS
N
E
E
V
F
D
D
F
D
D
L
L
IDEDIPPATQPIKASSYAQSS
A
F
V
KAPIQTSI
G
A
E
KL
S
K
E
E
F
I
E
A
W
Q
E
TAGKPQDDLEDEFDFDAPLTDASGR
P
M
S
R
A
M
Q
V
A
K
K
RLDLPTLP
G
F
E
L
L
DKVDPNKKVNF
T
E
E
Q
L
S
R
L
S
E
L
L
E
I
K
L
Q
EF
N
V
K
A
Q
V
V
EAQPG
P
V
V
T
R
F
E
L
DLAPGV
K
A
S
K
V
T
N
I
S
R
D
L
A
R
SMSM
A
S
V
R
V
V
E
VIPGK
P
Y
I
G
I
EVP
N
S
A
R
E
M
V
R
L
I
E
L
L
ETPAYR
D
P
S
A
L
I
S
M
A
MGKDISG--N
P
V
L
T
D
L
AKAP
H
M
L
V
AGTTGSG
K
S
V
A
V
N
S
M
I
L
S
M
L
L
KYTPD
Q
L
R
L
I
L
IDPK
Q
L
ELANYND
I
P
H
L
L
T
P
V
-
V
T
D
M
K
D
A
V
S
A
L
N
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
F
L
K
I
R
KL
S
D
Y
N
R
K
V
E
E
A
LANGEDLIDPTWKPSDS
A
T
Q
ERAPRLMPL
P
S
I
V
I
V
A
D
E
F
A
D
M
I
M
Q
V
G
K
K
A
E
E
M
I
T
R
L
A
Q
KSRAA
G
I
H
L
L
L
ATQRP
S
V
D
-
V
I
T
G
L
I
KANIP
T
R
V
A
L
R
VNSKIDS
R
T
I
LDAGG--
A
E
D
LLGHG
D
M
L
F
LGPGKI
E
P
E
RV
H
G
A
FISD
D
E
V
N
R
I
C
D
A
W
R
ERGE
P
D
Y
V
D
E
I
LTPFDE
E
P
A
SRGFEEGDGGS
D
R
D
A
L
Y
D
Q
C
V
S
F
V
L
E
TRKA
S
T
S
S
L
Q
R
K
F
SLG
Y
N
R
A
A
R
I
I
D
Q
M
EENG
I
V
S
AMGANGKRDILV
79
Fugue
94.22
60%
-121
- C3 -
-
2IUT
2
FTSK_PSEAE
A:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
R
E
S
P
D
D
E
P
--
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
22
PsiBlast_CBE
93.94
59%
-117
- C3 -
-
2IUU
1
FTSK_PSEAE
F:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
3
PsiBlast_PDB
93.92
59%
-119
- C3 -
-
2IUU
1
FTSK_PSEAE
A:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
26
PsiBlast_CBE
93.44
59%
-118
- C3 -
-
2IUU
1
FTSK_PSEAE
B:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
25
PsiBlast_CBE
93.43
59%
-116
- C3 -
-
2IUU
1
FTSK_PSEAE
C:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
24
PsiBlast_CBE
93.40
59%
-116
- C3 -
-
2IUU
1
FTSK_PSEAE
D:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
23
PsiBlast_CBE
93.28
59%
-118
- C3 -
-
2IUU
1
FTSK_PSEAE
E:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
2
PsiBlast_PDB
92.92
57%
-121
- C3 -
-
2IUT
2
FTSK_PSEAE
A:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
21
PsiBlast_CBE
92.74
57%
-122
- C3 -
-
2IUT
2
FTSK_PSEAE
B:
[70-477]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
P
L
S
L
L
D
P
A
E
V
K
Q
K
-
S
Y
S
P
E
S
L
E
A
M
S
R
L
L
E
I
K
L
K
E
F
G
V
E
V
S
V
D
S
V
H
P
G
P
V
I
T
R
F
E
I
Q
P
A
A
G
V
K
V
S
R
I
S
N
L
A
K
D
L
A
R
S
L
A
V
I
S
V
R
V
V
E
V
I
P
G
K
T
T
V
G
I
E
I
P
N
E
D
R
Q
M
V
R
F
S
E
V
L
S
S
P
E
Y
D
E
H
K
S
T
V
P
L
A
L
G
H
D
I
G
G
--
R
P
I
I
T
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
K
S
V
G
V
N
A
M
L
L
S
I
L
F
K
S
T
P
S
E
A
R
L
I
M
I
D
P
K
M
L
E
L
S
I
Y
E
G
I
P
H
L
L
C
P
V
-
V
T
D
M
K
E
A
A
N
A
L
R
W
S
V
A
E
M
E
R
R
Y
R
L
M
A
A
M
G
V
R
N
L
A
G
F
N
R
K
V
K
D
A
E
E
A
G
T
P
L
T
D
P
L
F
R
--
R
E
S
P
D
D
E
P
P
Q
L
S
T
L
P
T
I
V
V
V
V
D
E
F
A
D
M
M
M
I
V
G
K
K
V
E
E
L
I
A
R
I
A
Q
K
A
R
A
A
G
I
H
L
I
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
Q
V
S
S
K
I
D
S
R
T
I
L
D
Q
G
G
--
A
E
Q
L
L
G
H
G
D
M
L
Y
L
P
P
G
T
G
L
P
I
R
V
H
G
A
F
V
S
D
D
E
V
H
R
V
V
E
A
W
K
L
R
G
A
P
D
Y
I
E
D
I
L
A
-------------------------------------------------------------------------------
58
HHSearch
90.50
58%
-126
* C3 *
-
2IUS
-
FTSK_ECOLI
A:
[840-1248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
L
D
L
L
T
P
P
---------
T
F
A
L
E
Q
M
A
R
L
V
E
A
R
L
A
D
F
R
I
K
A
D
V
V
N
Y
S
P
G
P
V
I
T
R
F
E
L
N
L
A
P
G
V
K
A
A
R
I
S
N
L
S
R
D
L
A
R
S
L
S
T
V
A
V
R
V
V
E
V
I
P
G
K
P
Y
V
G
L
E
L
P
N
K
K
R
Q
T
V
Y
L
R
E
V
L
D
N
A
K
F
R
D
N
P
S
P
L
T
V
V
L
G
K
D
I
A
G
--
E
P
V
V
A
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
L
L
T
E
V
-
V
T
D
M
K
D
A
A
N
A
L
R
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
A
L
G
V
R
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
M
R
P
I
P
D
P
Y
W
----------
H
P
V
L
K
K
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
Q
A
G
--
A
E
S
L
L
G
M
G
D
M
L
Y
S
G
P
N
S
T
L
P
V
R
V
H
G
A
F
V
R
D
Q
E
V
H
A
V
V
Q
D
W
K
A
R
G
R
P
Q
Y
V
D
G
I
T
S
-------------------------------------------------------------------------------
1
PsiBlast_PDB
89.67
59%
-125
- C3 -
-
2IUS
-
FTSK_ECOLI
A:
[843-1248]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
L
L
T
P
P
--------------
T
F
A
L
E
Q
M
A
R
L
---
V
E
A
R
L
A
D
F
R
I
K
A
D
V
V
N
Y
S
P
G
P
V
I
T
R
F
E
L
N
L
A
P
G
V
K
A
A
R
I
S
N
L
S
R
D
L
A
R
S
L
S
T
V
A
V
R
V
V
E
V
I
P
G
K
P
Y
V
G
L
E
L
P
N
K
K
R
Q
T
V
Y
L
R
E
V
L
D
N
A
K
F
R
D
N
P
S
P
L
T
V
V
L
G
K
D
I
A
G
--
E
P
V
V
A
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
L
L
T
E
V
-
V
T
D
M
K
D
A
A
N
A
L
R
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
A
L
G
V
R
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
M
R
P
I
P
D
P
Y
W
---------
H
-
P
V
L
K
K
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
Q
A
G
--
A
E
S
L
L
G
M
G
D
M
L
Y
S
G
P
N
S
T
L
P
V
R
V
H
G
A
F
V
R
D
Q
E
V
H
A
V
V
Q
D
W
K
A
R
G
R
P
Q
Y
V
D
G
I
T
S
-------------------------------------------------------------------------------
59
HHSearch
89.35
58%
-127
- C3 -
-
2IUS
-
FTSK_ECOLI
D:
[840-1248]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
S
L
D
L
L
T
P
P
P
--------
T
F
A
L
E
Q
M
A
R
L
V
E
A
R
L
A
D
F
R
I
K
A
D
V
V
N
Y
S
P
G
P
V
I
T
R
F
E
L
N
L
A
P
G
V
K
A
A
R
I
S
N
L
S
R
D
L
A
R
S
L
S
T
V
A
V
R
V
V
E
V
I
P
G
K
P
Y
V
G
L
E
L
P
N
K
K
R
Q
T
V
Y
L
R
E
V
L
D
N
A
K
F
R
D
N
P
S
P
L
T
V
V
L
G
K
D
I
A
G
--
E
P
V
V
A
D
L
A
K
M
P
H
L
L
V
A
G
T
T
G
S
G
A
S
V
G
V
N
A
M
I
L
S
M
L
Y
K
A
Q
P
E
D
V
R
F
I
M
I
D
P
K
M
L
E
L
S
V
Y
E
G
I
P
H
L
L
T
E
V
-
V
T
D
M
K
D
A
A
N
A
L
R
W
C
V
N
E
M
E
R
R
Y
K
L
M
S
A
L
G
V
R
N
L
A
G
Y
N
E
K
I
A
E
A
D
R
M
M
R
P
I
P
D
P
Y
W
----------
H
P
V
L
K
K
E
P
Y
I
V
V
L
V
D
E
F
A
D
L
M
M
T
V
G
K
K
V
E
E
L
I
A
R
L
A
Q
K
A
R
A
A
G
I
H
L
V
L
A
T
Q
R
P
S
V
D
-
V
I
T
G
L
I
K
A
N
I
P
T
R
I
A
F
T
V
S
S
K
I
D
S
R
T
I
L
D
Q
A
G
--
A
E
S
L
L
G
M
G
D
M
L
Y
S
G
P
N
S
T
L
P
V
R
V
H
G
A
F
V
R
D
Q
E
V
H
A
V
V
Q
D
W
K
A
R
G
R
P
Q
Y
V
D
G
I
T
S
-------------------------------------------------------------------------------
28
PsiBlast_CBE
46.72
53%
-181
- C5 -
-
2VE9
2
FTSK_PSEAE
E:
[9-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
-
8
PsiBlast_PDB
46.09
53%
-184
- C5 -
-
2VE9
2
FTSK_PSEAE
A:
[8-66]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
-
31
PsiBlast_CBE
45.78
53%
-185
- C5 -
-
2VE9
2
FTSK_PSEAE
B:
[9-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
-
30
PsiBlast_CBE
45.25
53%
-174
- C5 -
-
2VE9
2
FTSK_PSEAE
C:
[8-66]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
-
67
HHSearch
45.21
18%
-34
- C3 -
-
5FV0
1
ECCC_GEOTN
A:
[293-515]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
F
I
P
V
G
L
D
E
Q
T
V-
R
P
V
A
I
N
M
R
T
D
P
H
C
L
I
V
G
Q
S
R
K
G
K
T
N
V
V
K
V
I
L
E
S
L
L
V
Q
-
E
P
--
E
S
I
G
L
L
D
G
I
D
R
G
L
A
G
Y
A
N
R
D
D
I
--
T
Y
-
I
E
A
K
E
R
L
A
Q
W
L
N
E
A
D
A
V
L
Q
Q
R
E
R
E
Y
I
Q
A
----
V
N
E
N
R
A
T
-----------------------------
T
L
A
W
P
P
V
V
F
V
V
D
S
L
L
R
L
Q
Q
E
T
D
S
I
M
Q
G
R
I
A
N
M
M
K
Q
Y
S
H
L
G
F
H
V
F
V
A
G
N
A
N
E
F
V
K
G
F
D
A
L
T
A
E
L
K
Q
I
R
Q
A
I
L
V
T
K
K
S
-
E
Q
S
L
F
A
L
P
F
T
R
N
E
Q
E
I
E
P
G
F
G
Y
F
V
V
G
G
K
--
D
Q
K
I
Q
I
P
K
----------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
45.21
53%
-173
- C5 -
-
2VE9
2
F:
[7-66]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
-
66
HHSearch
44.94
19%
-32
- C3 -
-
5FV0
1
ECCC_GEOTN
A:
[6-212]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
F
P
I
G
L
K
D
E
-S
Q
S
D
Y
F
Y
Q
W
L
E
D
G
N
I
G
I
F
G
S
A
G
Y
G
K
S
T
T
M
M
T
L
L
L
S
F
A
G
A
Y
N
P
A
Q
L
H
Y
Y
I
F
D
F
G
N
S
A
L
L
P
L
R
Q
L
P
H
T
A
D
Y
F
R
L
D
D
E
K
K
I
E
K
F
I
K
F
M
K
E
E
M
E
Q
R
K
Q
R
F
M
E
K
E
V
S
T
I
K
L
Y
N
A
L
S
E
----------------------------
E
K
L
P
I
I
I
V
A
L
D
N
F
D
V
V
K
E
E
M
-
P
D
F
E
T
Q
L
I
Q
Y
A
R
D
G
Q
S
L
G
I
F
F
I
M
T
A
T
R
V
S
G
---
I
R
P
P
L
M
N
N
L
K
T
K
I
V
H
Y
F
I
D
S
S
E
K
F
S
L
I
G
R
T
----------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
44.58
53%
-178
- C5 -
-
2VE9
2
FTSK_PSEAE
D:
[9-66]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
L
Y
D
E
A
V
R
F
V
T
E
S
R
R
A
S
I
S
A
V
Q
R
K
L
K
I
G
Y
N
R
A
A
R
M
I
E
A
M
E
M
A
G
V
V
T
P
M
N
T
N
G
S
R
E
V
I
-