@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTG7: (2017-12-13 )
MKRVVITGMGINSCIGNSLEEVTHSLKNGISGTRFNPTYAELNFKSHVSAAAEQDFDNIDRKLKRFMGVCAMYAYNSAVAAVEHAGLKAEDLADNPRYGIAGGSGGGSTASVVEMTELLETKGARKVGPFFVPRNMTNTITANVGVAFKLQGIAHSIASACATSADAIGYAYNLIALGKQDLMLAGGGEEDHWSQSLLFDAMGALCSKYNDTPETASRPYSKDRDGFVIAGGGGFVVLESLEHAQARGANILAEVVAYAANSDGADMVAPSGEGATRCILMALEEAKQHGVDKIDYVNTHGTSTPAGDVTELKAMERAFGEGKVPPLSSTKSMTGHSLGAAGVHEAIYSVLMLQNDFIAPNINVTELDEGTEGFDIVLEKRDTKLNTVMSNSFGFGGVNACLIFKKWDA
Atome Classification :
(36 SA)
.........10........20........30.--.......40.--.......50.------...--.---..-.60........70-------.........80-------.........90..----......100.......110.......120.........130.......140.......150.......160.......170.......180.......190......-.200.......210.......220.......230.......240.......250.......260.......--270-...--.....280.......290-.--.......300.......310.......320.-..-.---..-..330.......340.......350.......360.......-370....------..-.380.-..-.....390.......400.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
K
R
V
V
I
TGMG
I
N
S
C
IG
N
S
L
E
E
V
T
H
S
L
KNGISG--TRFNP
T
Y
A
E
L
--N
F
K
S
H
V
S
A
A
A
------
E
Q
D
--
F
---
D
N
-
I
D
R
K
L
K
R
F
M
G
V
C
--------
A
M
Y
A
Y
N
S
A
V
A
--------
A
V
E
HAGL
K
A
E
DLA----DNPRYGIAGGSGGGS
T
A
S
V
V
E
M
T
E
L
L
E
--TKGARKVG
P
F
FVPRNMT
N
T
I
TANV
G
V
A
F
K
L
Q
G
I
A
H
S
I
A
S
A
C
ATS
A
D
A
I
G
Y
A
Y
N
L
IALGKQ
D
L
M
L
AGGGEE
D
H
W
S
Q
S
L
L
-
F
D
A
M
G
A
L
C
S
KYNDTPETASRPYSKDRD
G
F
V
I
AGGG
G
F
V
V
L
E
S
L
E
H
A
QAR
G
A
N
I
L
A
E
V
V
A
Y
AANSDGADMVA--PS--GEG--
A
T
R
C
I
L
M
A
L
E
E
A
K
QHGV--D--K
I
D
Y
VNTHGTSTPA
G
D
V
T
E
L
K
A
M
E
R
A
FGE-G-KV-P---PL-SSTKSMTGHSL
G
A
A
G
V
H
E
A
I
Y
S
V
L
M
LQNDFIAPNI
N
V
T
ELDE-GTEG
F
D
I
------
V
L
-EK-RD-T
K
-
L
N
T
VMSNSFGFGG
V
N
A
C
L
I
F
KKWDA
70
PsiBlast_CBE
94.68
55%
-17
- C1 -
-
1EK4
2
FABB_ECOLI
B:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
S
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
43
PsiBlast_CBE
94.18
55%
-21
- C1 -
-
2BYX
2
FABB_ECOLI
C:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
A
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
159
HHSearch
94.00
55%
-21
* C1 *
-
2VBA
1
FABB_ECOLI
A:
[1-404]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
T-
T
---
G
L
-
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
-
Q
V
F
G
A
D
A
M
R
G
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
H
G
V
---
D
---
T
--
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
L
--
69
PsiBlast_CBE
94.00
55%
-18
- C1 -
-
1EK4
2
FABB_ECOLI
C:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
S
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
68
PsiBlast_CBE
94.00
55%
-17
- C1 -
-
1EK4
2
FABB_ECOLI
D:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
S
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
19
PsiBlast_PDB
93.86
55%
-17
- C1 -
-
2BZ4
-
FABB_ECOLI
A:
[13-415]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
Q
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
15
PsiBlast_PDB
93.76
55%
-19
- C1 -
-
2BYW
-
FABB_ECOLI
A:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
A
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
10
PsiBlast_PDB
93.74
55%
-18
- C1 -
-
2AQB
1
FABB_ECOLI
A:
[1-403]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
42
PsiBlast_CBE
93.72
55%
-22
- C1 -
-
2BYX
2
FABB_ECOLI
D:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
A
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
35
PsiBlast_CBE
93.66
55%
-17
- C1 -
-
2AQ7
1
FABB_ECOLI
B:
[2-403]
-
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
16
PsiBlast_PDB
93.45
55%
-21
- C1 -
-
2BYX
2
FABB_ECOLI
A:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
A
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
74
PsiBlast_CBE
93.44
55%
-17
- C1 -
-
1F91
2
FABB_ECOLI
B:
[1-403]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
S
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
54
PsiBlast_CBE
93.40
55%
-18
- C1 -
-
2BYZ
2
FABB_ECOLI
D:
[13-415]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
Q
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
34
PsiBlast_CBE
93.33
55%
-19
- C1 -
-
2AQ7
1
FABB_ECOLI
D:
[2-403]
-
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
44
PsiBlast_CBE
93.26
55%
-21
- C1 -
-
2BYX
2
FABB_ECOLI
B:
[13-415]
M
K
R
V
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
A
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
14
PsiBlast_PDB
93.21
55%
-18
- C1 -
-
2VBA
1
FABB_ECOLI
A:
[1-403]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
8
PsiBlast_PDB
93.13
55%
-17
- C1 -
-
2BUI
2
FABB_ECOLI
A:
[1-403]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
57
PsiBlast_CBE
93.07
55%
-18
- C1 -
-
2BZ3
2
FABB_ECOLI
D:
[13-415]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
E
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
38
PsiBlast_CBE
92.90
55%
-21
- C1 -
-
1FJ8
2
FABB_ECOLI
B:
[2-403]
-
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
11
PsiBlast_PDB
92.86
55%
-16
- C1 -
-
2VB7
-
FABB_ECOLI
A:
[1-403]
M
K
R
A
V
I
T
G
L
G
I
V
S
S
I
G
N
N
Q
Q
E
V
L
A
S
L
R
E
G
R
S
G
--
I
T
F
S
Q
E
L
K
D
S
--
G
M
R
S
H
V
W
G
N
V
------
K
L
D
--
T
---
T
G
L
I
D
R
K
V
V
R
F
M
S
D
A
--------
S
I
Y
A
F
L
S
M
E
Q
--------
A
I
A
D
A
G
L
S
P
E
A
Y
Q
----
N
N
P
R
V
G
L
I
A
G
S
G
G
G
S
P
R
F
Q
V
F
G
A
D
A
M
R
G-
P
R
G
L
K
A
V
G
P
Y
V
V
T
K
A
M
A
S
G
V
S
A
C
L
A
T
P
F
K
I
H
G
V
N
Y
S
I
S
S
A
C
A
T
S
A
H
C
I
G
N
A
V
E
Q
I
Q
L
G
K
Q
D
I
V
F
A
G
G
G
E
E
L
C
W
E
M
A
C
E
-
F
D
A
M
G
A
L
S
T
K
Y
N
D
T
P
E
K
A
S
R
T
Y
D
A
H
R
D
G
F
V
I
A
G
G
G
G
M
V
V
V
E
E
L
E
H
A
L
A
R
G
A
H
I
Y
A
E
I
V
G
Y
G
A
T
S
D
G
A
D
M
V
A
--
P
S
--
G
E
G
--
A
V
R
C
M
K
M
A
M
-----
H
G
V
--
D
T-
P
I
D
Y
L
N
S
H
G
T
S
T
P
V
G
D
V
K
E
L
A
A
I
R
E
V
F
G
D
---
K
S
-
P
---
A
I
-
S
A
T
K
A
M
T
G
H
S
L
G
A
A
G
V
Q
E
A
I
Y
S
L
L
M
L
E
H
G
F
I
A
P
S
I
N
I
E
E
L
D
E
-
Q
A
A
G
L
N
I
------
V
T
-
E
T
-
T
D
-
R
E
-
L
T
T
V
M
S
N
S
F
G
F
G
G
T
N
A
T
L
V
M
R
K
---
65
PsiBlast_CBE
89.38
52%
-21
- C1 -
-
3MQD
1
?
A:
[22-426]
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
--
I
S
R
A
E
E
Y
A
E
L
--
G
F
R
C
Q
V
H
G
A
P
------
D
I
D
--
I
---
E
S
L
V
D
R
R
A
M
R
F
H
G
R
G
--------
T
A
W
N
H
I
A
M
D
Q
--------
A
I
A
D
A
G
L
T
E
E
E
V
S
-----
N
E
R
T
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
--
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
L
S
V
L
-
F
D
A
M
G
A
M
S
S
K
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
A
--
P
S
--
G
E
G
--
A
I
R
C
M
K
M
A
L
S
T
V
----
T
--
S
--
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
A
-
G
-
D
V
C
P
---
P
I
-
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
P
-
A
F
A
D
M
P
I
------
V
R
-
K
R
-
I
D
N
V
Q
-
L
N
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
--
67
PsiBlast_CBE
89.35
52%
-20
- C1 -
-
3U0F
3
?
A:
[5-409]
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
--
I
S
R
A
E
E
Y
A
E
L
--
G
F
R
C
Q
V
H
G
A
P
------
D
I
D
--
I
---
E
S
L
V
D
R
R
A
M
R
F
H
G
R
G
--------
T
A
W
N
H
I
A
M
D
Q
--------
A
I
A
D
A
G
L
T
E
E
E
V
S
-----
N
E
R
T
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
--
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
L
S
V
L
-
F
D
A
M
G
A
M
S
S
K
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
A
--
P
S
--
G
E
G
--
A
I
R
C
M
K
M
A
L
S
T
V
----
T
--
S
--
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
A
-
G
-
D
V
C
P
---
P
I
-
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
P
-
A
F
A
D
M
P
I
------
V
R
-
K
R
-
I
D
N
V
Q
-
L
N
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
--
151
HHSearch
85.65
53%
-6
- C1 -
-
3MQD
1
?
A:
[22-427]
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
--
I
S
R
A
E
E
Y
A
E
L
--
G
F
R
C
Q
V
H
G
-
A
------
P
D
I
DI
E
---
S
L
-
V
D
R
R
A
M
R
F
H
G
R
G
--------
T
A
W
N
H
I
A
M
D
Q
--------
A
I
A
D
A
G
L
T
E
E
E
V
-----
S
N
E
R
T
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
--
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
L
S
V
L
-
F
D
A
M
G
A
M
S
S
K
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
A
--
P
S
--
G
E
G
--
A
I
R
C
M
K
M
A
L
S
T
V
----
T
--
S
--
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
A
-
G
D
V
C
-
P
---
P
I
-
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
P
-
A
F
A
D
M
P
I
------
V
R
-
K
R
I
D
N
-
V
Q
-
L
N
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
Q
-
155
HHSearch
85.42
53%
-6
- C1 -
-
3U0F
3
?
A:
[5-410]
M
R
R
V
V
V
T
G
M
G
I
V
S
S
I
G
S
N
T
E
E
V
T
A
S
L
R
E
A
K
S
G
--
I
S
R
A
E
E
Y
A
E
L
--
G
F
R
C
Q
V
-
H
G
A
------
P
D
I
D
I
E
---
S
L
-
V
D
R
R
A
M
R
F
H
G
R
G
--------
T
A
W
N
H
I
A
M
D
Q
--------
A
I
A
D
A
G
L
T
E
E
E
V
-----
S
N
E
R
T
G
I
I
M
G
S
G
G
P
S
T
R
T
I
V
D
S
A
D
I
T
R
--
E
K
G
P
K
R
V
G
P
F
A
V
P
K
A
M
S
S
T
A
S
A
T
L
A
T
F
F
K
I
K
G
I
N
Y
S
I
S
S
A
C
A
T
S
N
H
C
I
G
N
A
Y
E
M
I
Q
Y
G
K
Q
D
R
M
F
A
G
G
C
E
D
L
D
W
T
L
S
V
L
-
F
D
A
M
G
A
M
S
S
K
Y
N
D
T
P
S
T
A
S
R
A
Y
D
K
N
R
D
G
F
V
I
A
G
G
A
G
V
L
V
L
E
D
L
E
T
A
L
A
R
G
A
K
I
Y
G
E
I
V
G
Y
G
A
T
S
D
G
Y
D
M
V
A
--
P
S
--
G
E
G
--
A
I
R
C
M
K
M
A
L
S
T
V
----
T
--
S
--
K
I
D
Y
I
N
P
H
A
T
S
T
P
A
G
D
A
P
E
I
E
A
I
R
Q
I
F
G
A
-
G
D
V
C
-
P
---
P
I
-
A
A
T
K
S
L
T
G
H
S
L
G
A
T
G
V
Q
E
A
I
Y
S
L
L
M
M
Q
N
N
F
I
C
E
S
A
H
I
E
E
L
D
P
-
A
F
A
D
M
P
I
------
V
R
-
K
R
I
D
N
-
V
Q
-
L
N
T
V
L
S
N
S
F
G
F
G
G
T
N
A
T
L
V
F
Q
R
Y
Q
-
112
PsiBlast_CBE
72.90
39%
-1
- C1 -
-
3HO9
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
114
PsiBlast_CBE
72.80
39%
-2
- C1 -
-
3HNZ
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
111
PsiBlast_CBE
72.58
39%
-2
- C1 -
-
3I8P
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
113
PsiBlast_CBE
72.26
39%
-3
- C1 -
-
3HO2
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
A
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
115
PsiBlast_CBE
72.24
39%
-0
- C1 -
-
3G11
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
117
PsiBlast_CBE
70.59
39%
0
- C1 -
-
2GFX
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
116
PsiBlast_CBE
69.60
39%
2
- C1 -
-
3G0Y
1
FABF_ECOLI
A:
[18-426]
-
R
R
V
V
V
T
G
L
G
M
L
S
P
V
G
N
T
V
E
S
T
W
K
A
L
L
A
G
Q
S
G
--
I
S
L
I
D
H
F
D
T
S
--
A
Y
A
T
K
F
-
A
G
L
------
V
K
D
--
F
NCE
D
I
-
I
S
R
K
E
Q
R
K
M
D
A
F
--------
I
Q
Y
G
I
V
A
G
V
Q
--------
A
M
Q
D
S
G
L
E
I
T
E
-
E
----
N
A
T
R
I
G
A
A
I
G
S
G
I
G
G
L
G
L
I
E
E
N
H
T
S
L
M
--
N
G
G
P
R
K
I
S
P
F
F
V
P
S
T
I
V
N
M
V
A
G
H
L
T
I
M
Y
G
L
R
G
P
S
I
S
I
A
T
A
Q
T
S
G
V
H
N
I
G
H
A
A
R
I
I
A
Y
G
D
A
D
V
M
V
A
G
G
A
E
K
A
S
T
P
L
G
V
G
G
F
G
A
A
R
A
L
S
T
R
-
N
D
N
P
Q
A
A
S
R
P
W
D
K
E
R
D
G
F
V
L
G
D
G
A
G
M
L
V
L
E
E
Y
E
H
A
K
K
R
G
A
K
I
Y
A
E
L
V
G
F
G
M
S
S
D
A
Y
H
M
T
S
--
P
P
---
E
N
--
G
A
G
A
A
L
A
M
A
N
A
L
R
D
A
G
I
--
E
AS
Q
I
G
Y
V
N
A
H
G
T
S
T
P
A
G
D
K
A
E
A
Q
A
V
K
T
I
F
G
E
-
A
-
A
S
-
R
---
V
L
V
S
S
T
K
S
M
T
G
H
L
L
G
A
A
G
A
V
E
S
I
Y
S
I
L
A
L
R
D
Q
A
V
P
P
T
I
N
L
D
N
P
D
E
-
G
C
D
L
D
F
V
------
P
H
-
E
A
-
R
Q
-
V
S
G
M
E
Y
T
L
C
N
S
F
G
F
G
G
T
N
G
S
L
I
F
K
K
---
128
PsiBlast_CBE
67.37
35%
5
- C1 -
-
2IWZ
2
OXSM_HUMAN
A:
[21-433]
-
R
R
V
V
I
T
G
I
G
L
V
T
P
L
G
V
G
T
H
L
V
W
D
R
L
I
G
G
E
S
G
IV
S
L
V
G
E
E
Y
K
S
I
PC
S
V
A
A
Y
V
P
R
G
S
DEGQFN
E
Q
N
--
F
------
V
S
K
S
D
I
K
S
M
S
S
P
--------
T
I
M
A
I
G
A
A
E
L
--------
A
M
K
D
S
G
W
H
P
Q
S
E
A
----
D
Q
V
A
T
G
V
A
I
G
M
G
M
I
P
L
E
V
V
S
E
T
A
L
N
F
Q
--
T
K
G
Y
N
K
V
S
P
F
F
V
P
K
I
L
V
N
M
A
A
G
Q
V
S
I
R
Y
K
L
K
G
P
N
H
A
V
S
T
A
C
T
T
G
A
H
A
V
G
D
S
F
R
F
I
A
H
G
D
A
D
V
M
V
A
G
G
T
D
S
C
I
S
P
L
S
L
A
G
F
S
R
A
R
A
L
S
T
--
N
S
D
P
K
L
A
C
R
P
F
H
P
K
R
D
G
F
V
M
G
E
G
A
A
V
L
V
L
E
E
Y
E
H
A
V
Q
R
R
A
R
I
Y
A
E
V
L
G
Y
G
L
S
G
D
A
G
H
I
T
A
PD
P
E
--
G
E
G
--
A
L
R
C
M
A
A
A
L
K
D
A
G
V
Q
-
P
--
E
--
E
I
S
Y
I
N
A
H
A
T
S
T
P
L
G
D
A
A
E
N
K
A
I
K
H
L
F
K
D
H
A
-
Y
A
-
L
---
A
V
-
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
A
F
T
T
L
A
C
Y
Y
Q
K
L
P
P
T
L
N
---
L
D
C
-
S
E
P
E
F
D
L
NYVPL
K
A
Q
-
E
W
-
K
T
-
E
K
-
R
F
I
G
L
T
N
S
F
G
F
G
G
T
N
A
T
L
-------
124
PsiBlast_CBE
60.48
36%
12
- C1 -
-
2IX4
2
KASM_ARATH
A:
[1-428]
-
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
--
I
R
-
G
L
T
L
D
D
L
--
K
M
K
S
F
D
E
E
T
K
------
L
Y
T
--
F
---
D
Q
-
L
S
S
K
V
A
A
F
V
P
Y
G
SNPGEFDE
A
L
W
L
N
S
K
A
V
A
N
F
I
G
Y
A
V
C
A
A
D
E
A
L
R
D
A
E
W
L
P
TE
E
E
E
K
E
R
T
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
--
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
K
F
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
--
P
P
ED
G
K
G
--
A
V
L
A
M
T
R
A
L
---
R
Q
S
G
L
CP
N
--
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
-
H
-
A
T
-
S
GT
L
A
F
-
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
K
R
F
M
P
------
L
T
-
T
S
-
K
K
-
M
L
-
V
R
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
-----
123
PsiBlast_CBE
60.34
36%
14
- C1 -
-
2IX4
2
KASM_ARATH
B:
[1-428]
-
R
R
V
V
V
T
G
L
G
M
V
T
P
L
G
R
G
V
E
T
T
W
R
R
L
I
D
G
E
C
G
--
I
R
-
G
L
T
L
D
D
L
--
K
M
K
S
F
D
E
E
T
K
------
L
Y
T
--
F
---
D
Q
-
L
S
S
K
V
A
A
F
V
P
Y
G
SNPGEFDE
A
L
W
L
N
S
K
A
V
A
NFIGYAVC
A
A
D
E
A
L
R
D
A
E
W
L
P
TEEE
E
K
E
R
T
G
V
S
I
G
G
G
I
G
S
I
C
D
I
V
E
A
A
Q
L
I
C
--
E
K
R
L
R
R
L
S
P
F
F
I
P
K
I
L
V
N
M
A
S
G
H
V
S
M
K
Y
G
F
Q
G
P
N
H
A
A
V
T
A
C
A
T
G
A
H
S
I
G
D
A
T
R
M
I
Q
F
G
D
A
D
V
M
V
A
G
G
T
E
S
S
I
D
A
L
S
V
A
G
F
S
R
S
R
A
L
S
T
K
F
N
S
S
P
Q
E
A
S
R
P
F
D
C
D
R
D
G
F
V
I
G
E
G
S
G
V
I
V
L
E
E
Y
E
H
A
K
R
R
G
A
K
I
Y
A
E
L
C
G
Y
G
M
S
G
D
A
H
H
I
T
Q
--
P
P
ED
G
K
G
--
A
V
L
A
M
T
R
A
L
---
R
Q
S
G
L
CP
N
--
Q
I
D
Y
V
N
A
H
A
T
S
T
P
I
G
D
A
V
E
A
R
A
I
K
T
V
F
S
E
-
H
-
A
T
-
S
GTL
A
F
-
S
S
T
K
G
A
T
G
H
L
L
G
A
A
G
A
V
E
A
I
F
S
I
L
A
I
H
H
G
V
A
P
M
T
L
N
V
K
N
P
D
P
I
F
D
K
R
F
M
P
------
L
T
-
T
S
-
K
K
-
M
L
-
V
R
T
A
M
S
N
S
F
G
F
G
G
T
N
A
S
L
L
F
-----
135
PsiBlast_CBE
53.37
36%
-26
- C1 -
-
2WGE
7
FAB1_MYCTU
A:
[104-416]
---------------------------------------------------------------------------------------------------------------------------------
D
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
--
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
-
A
F
S
M
M
R
A
M
S
T
R
N
D
E
P
E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
E
T
E
E
H
A
K
A
R
G
A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
--
P
A
--
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
--
D
---
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
-
Q
-
A
A
------
V
-
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
-
E
I
D
-
L
D
V
------
V
A
G
E
P
-
R
Y
-
G
D
-
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--
136
PsiBlast_CBE
51.82
36%
-26
- C1 -
-
2WGD
4
FAB1_MYCTU
A:
[104-416]
---------------------------------------------------------------------------------------------------------------------------------
D
P
D
R
F
A
V
V
V
G
T
G
L
G
G
A
E
R
I
V
E
S
Y
D
L
M
N
--
A
G
G
P
R
K
V
S
P
L
A
V
Q
M
I
M
P
N
G
A
A
A
V
I
G
L
Q
L
G
A
R
A
G
V
M
T
P
V
S
A
C
S
S
G
S
E
A
I
A
H
A
W
R
Q
I
V
M
G
D
A
D
V
A
V
C
G
G
V
E
G
P
I
E
A
L
P
I
A
-
A
F
S
M
M
R
A
M
S
T
R
N
D
E
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E
R
A
S
R
P
F
D
K
D
R
D
G
F
V
F
G
E
A
G
A
L
M
L
I
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T
E
E
H
A
K
A
R
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A
K
P
L
A
R
L
L
G
A
G
I
T
S
D
A
F
H
M
V
A
--
P
A
--
A
D
G
V
R
A
G
R
A
M
T
R
S
L
E
L
A
G
L
S
P
A
--
D
---
I
D
H
V
N
A
H
G
T
A
T
P
I
G
D
A
A
E
A
N
A
I
R
V
A
G
C
D
-
Q
-
A
A
------
V
-
Y
A
P
K
S
A
L
G
H
S
I
G
A
V
G
A
L
E
S
V
L
T
V
L
T
L
R
D
G
V
I
P
P
T
L
N
Y
E
T
P
D
P
-
E
I
D
-
L
D
V
------
V
A
G
E
P
-
R
Y
-
G
D
-
Y
R
Y
A
V
N
N
S
F
G
F
G
G
H
N
V
A
L
A
F
G
R
Y
--