@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VTQ6: (2017-12-14 )
MSLLQQLAIKHPIFLAPMAGVSTPELAAEVSNQGGLGSLGLGANTPQSAREQILKTQALTENPFQVNFFCHQSTELNVEKAKQWLEYLRPHFEKFGAQPPQELHCIYPSFLDNDDFLNVVLETKPKTVSFHFGIPHPHQIKALKEAGILTMVSATNLIEAQAIEAAGIDIIIAQGIEAGGHRGIFNQTFDGAIKTSDLVQLIVQHCTLPVVAAGGIMTGLQAKHMLGLGAAAVQLGTAFVQCQTSNASAEYRKALFSKPVTQISASLSGRPARGILNHWHIKIDSPTRPVQPEYPYAYDLAKQLNALATKHQDYGFGAFWAGSNVAQIRELEAPDLVNQLVVEMLDNE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90....----....100.......110.......120.......130.......140.......150.......160.......170.......180...-.-..-.190.......200.......210.......220.......230.......240.......250......--.260.........270.......280.......290....----....300........310.......320.......330..-.....340......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
S
L
L
Q
Q
L
A
IKH
P
I
F
L
APMAGVS
T
P
E
L
A
A
E
VSNQGGLGSLGLGANT
P
Q
S
A
R
E
Q
I
L
K
T
QALTENP
F
Q
V
N
F
F
CHQSTEL
N
V
E
K
A
K
Q
W
L
E
Y
L
R
P
H
F
E
K
F----GAQPPQ
E
L
H
C
IY
P
S
FLDN
D
D
F
L
N
V
V
LETKP
K
T
V
S
F
HFGIPH
P
H
Q
I
K
A
L
K
EAG
I
L
T
M
V
SATNL
I
E
A
Q
AIEAAG
I
D
I
I
I
AQGIEAGGHRGIF-N-QT-FDGAI
K
T
S
D
L
V
Q
L
I
V
Q
HCTL
P
V
VAA
G
G
I
M
T
G
L
Q
A
K
H
M
LG
L
G
A
A
A
V
Q
L
G
T
A
F
V
Q
C
QTSNA
S
A
E
Y
R
K
A
L
F
SK--
P
V
--
T
Q
I
S
A
SLSGRPARGI
L
N
H
W
H
I
K
IDSPTRPVQ-PEY
P
----
Y
A
Y
D
L
-
A
K
Q
L
N
A
L
A
T
KHQDYGF
G
A
F
WAGS
N
V
A
Q
I
RELE
A
P
-
D
L
V
N
Q
L
V
V
E
M
LDNE
59
HHSearch
85.58
46%
-67
- C3 -
-
4QIT
2
?
B:
[10-356]
-
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
-
E
-
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
RA
A
R
--
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
-
P
A
A
E
L
L
R
T
L
V
E
E
L
R
---
23
PsiBlast_CBE
84.47
46%
-61
- C3 -
-
4QIT
2
?
B:
[15-355]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
3
PsiBlast_PDB
84.12
46%
-62
- C3 -
-
4QIT
2
?
A:
[15-355]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
S
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
58
HHSearch
83.92
46%
-65
- C3 -
-
4Q4K
1
?
A:
[3-350]
D
R
F
T
R
L
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
-
E
-
P
E
R
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
RA
A
R
--
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
R
---
4
PsiBlast_PDB
83.10
46%
-65
- C3 -
-
4QIU
2
?
A:
[14-354]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
2
PsiBlast_PDB
82.98
46%
-61
- C3 -
-
4QIS
1
?
A:
[14-354]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
24
PsiBlast_CBE
82.84
46%
-64
- C3 -
-
4QIU
2
?
B:
[14-354]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
C
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
AR
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
22
PsiBlast_CBE
82.78
46%
-62
- C3 -
-
4QIS
1
?
B:
[14-354]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
21
PsiBlast_CBE
82.76
46%
-62
- C3 -
-
4Q4K
1
?
B:
[9-349]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
1
PsiBlast_PDB
82.19
46%
-63
* C3 *
-
4Q4K
1
?
A:
[9-349]
------
L
G
I
Q
Q
P
I
I
Q
A
P
M
L
G
V
S
T
P
A
L
A
A
A
V
S
N
A
G
G
L
G
S
I
A
I
T
G
S
A
A
E
K
G
R
A
L
I
R
E
V
R
G
L
T
D
K
P
F
N
V
N
L
F
C
H
R
P
G
Q
A
D
P
A
R
E
R
A
W
L
D
Y
L
K
P
L
F
A
E
F
----
G
A
E
P
P
V
R
L
K
N
I
Y
L
S
F
L
E
D
P
T
L
L
P
M
L
L
E
E
R
P
A
A
V
S
F
H
F
G
A
P
P
R
D
Q
V
R
A
L
Q
A
V
G
I
R
V
L
V
C
A
T
T
P
E
E
A
A
L
V
E
A
A
G
A
D
A
V
V
A
Q
G
I
E
A
G
G
H
R
G
V
F
-
E
P
E
R
-
G
D
A
A
I
G
T
L
A
L
V
R
L
L
A
A
R
G
S
L
P
V
V
A
A
G
G
I
M
D
G
R
G
I
R
A
A
L
E
L
G
A
S
A
V
Q
M
G
T
A
F
V
L
C
P
E
S
S
A
N
A
A
Y
R
E
A
L
K
G
P
--
R
A
A
R
T
A
L
T
V
T
M
S
G
R
S
A
R
G
L
P
N
R
M
F
F
D
A
A
A
P
G
V
P
P
L
-
P
D
Y
P
----
F
V
Y
D
A
-
T
K
A
L
Q
T
A
A
L
A
R
G
N
H
D
F
A
A
Q
W
A
G
Q
G
A
A
L
A
R
E
L
P
A
A
-
E
L
L
R
T
L
V
E
E
L
----
60
HHSearch
74.29
35%
-71
- C3 -
-
5LSM
2
?
A:
[3-348]
C
R
L
T
R
L
F
G
I
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
L
S
L
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
H
R
E
P
V
A
Q
A
A
K
Q
A
A
W
L
E
Q
L
A
P
Y
F
A
E
F
----
N
L
D
-
P
N
-------
R
T
P
Y
S
K
A
Q
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
H
F
-
L
-
S
E
D
L
T
E
Q
L
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
AA
Q
H
--
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
M
A
E
M
G
P
M
N
E
A
-
V
-
P
D
F
P
----
L
A
S
S
A
-
V
A
G
L
R
T
A
A
E
R
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
S
G
C
R
A
I
P
A
A
-
D
L
T
R
S
F
V
L
S
L
P
---
26
PsiBlast_CBE
70.93
35%
-45
- C3 -
-
5LSM
2
?
F:
[5-347]
--
L
T
R
L
F
G
I
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
L
S
L
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
H
R
E
P
V
A
Q
A
A
K
Q
A
A
W
L
E
Q
L
A
P
Y
F
A
E
F
NL----------
R
T
P
Y
-----
S
K
A
Q
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
H
F
L
S
-
E
D
-
L
T
E
Q
L
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
--
A
A
Q
H
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
M
A
E
M
-
G
P
M
N
E
A
V
-
P
D
F
P
----
L
A
S
S
A
-
V
A
G
L
R
T
A
A
E
R
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
S
G
C
R
A
I
P
A
A
-
D
L
T
R
S
F
V
L
S
L
----
5
PsiBlast_PDB
70.34
35%
-37
- C3 -
-
5LSM
2
?
A:
[5-347]
--
L
T
R
L
F
G
I
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
L
S
L
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
H
R
E
P
V
A
Q
A
A
K
Q
A
A
W
L
E
Q
L
A
P
Y
F
A
E
F
NLDP
N
-------
R
T
P
Y
-----
S
K
A
Q
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
H
F
L
S
-
E
D
-
L
T
E
Q
L
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
--
A
A
Q
H
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
M
A
E
M
-
G
P
M
N
E
A
V
-
P
D
F
P
----
L
A
S
S
A
-
V
A
G
L
R
T
A
A
E
R
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
S
G
C
R
A
I
P
A
A
-
D
L
T
R
S
F
V
L
S
L
----
25
PsiBlast_CBE
69.29
35%
-35
- C3 -
-
5LSM
1
?
H:
[5-343]
--
L
T
R
L
F
G
I
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
L
S
L
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
H
R
E
P
V
A
Q
A
A
K
Q
A
A
W
L
E
Q
L
A
P
Y
F
A
E
F
LD-----------
T
P
Y
-----
S
K
A
Q
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
H
F
L
S
-
E
D
-
L
T
E
Q
L
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
--
A
A
Q
H
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
M
A
E
M
-
G
P
M
N
E
A
V
-
P
D
F
P
----
L
A
S
S
A
-
V
A
G
L
R
T
A
A
E
R
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
S
G
C
R
A
I
P
A
A
-
D
L
T
R
S
F
--------
27
PsiBlast_CBE
68.16
35%
-30
- C3 -
-
5LSM
2
?
E:
[5-347]
--
L
T
R
L
F
--
E
F
P
I
I
Q
A
P
M
A
G
V
Q
G
S
A
L
A
I
A
V
S
E
A
G
G
L
G
S
L
P
C
A
M
L
S
L
E
A
L
E
A
E
L
T
A
I
R
S
Q
T
A
K
P
I
N
V
N
F
F
C
H
R
E
P
-
A
Q
A
A
K
Q
A
A
W
L
E
Q
L
A
P
Y
F
A
E
F
NLDP
N
-----
A
Q
R
T
P
Y
-----
S
K
A
Q
A
E
V
L
A
K
F
K
P
E
V
V
S
F
H
F
G
L
P
D
E
E
L
L
L
E
I
K
S
W
G
S
K
V
I
S
T
A
T
T
V
E
E
A
L
W
L
E
A
R
G
A
D
A
I
I
A
Q
G
L
E
A
G
G
H
R
G
H
F
L
S
-
E
D
-
L
T
E
Q
L
G
T
F
S
L
L
P
Q
I
I
A
A
V
E
I
P
V
I
A
A
G
G
I
V
D
A
T
T
V
R
A
A
M
T
M
G
A
S
A
V
Q
V
G
T
A
Y
L
L
C
P
E
C
N
T
S
A
I
H
R
E
A
L
Q
S
D
--
A
A
Q
H
T
A
L
T
N
L
F
S
G
R
P
A
R
G
I
V
N
R
F
M
A
E
M
-
G
P
M
N
E
A
V
-
P
D
F
P
----
L
A
S
S
A
-
V
A
G
L
R
T
A
A
E
R
L
G
F
W
D
F
S
P
L
W
C
G
Q
N
A
S
G
C
R
A
I
P
A
A
-
D
L
T
R
S
F
V
L
S
L
----
68
HHSearch
64.95
32%
-74
- C3 -
-
5GVH
1
?
A:
[5-304]
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
M
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
W
------------------------------------------
A
D
D
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
-----------
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
SI
R
D
--
T
V
V
T
G
A
K
L
G
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
E
M
E
F
E
---
N
P
M
Q
----
A
E
E
M
L
-
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
M
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
T
-
67
HHSearch
64.50
32%
-83
- C3 -
-
5GVJ
-
?
B:
[5-303]
T
R
V
T
D
L
L
E
I
E
H
P
I
L
M
G
G
M
A
W
A
G
T
P
T
L
A
A
A
V
S
E
A
G
G
L
G
I
I
G
S
G
A
M
K
P
D
D
L
R
K
A
I
S
E
L
R
Q
K
T
D
K
P
F
G
V
N
I
I
L
V
S
P
W
------------------------------------------
A
D
D
L
V
K
V
C
I
E
E
K
V
P
V
V
T
F
G
A
G
N
P
-
T
K
Y
I
R
E
L
K
E
N
G
T
K
V
I
P
V
V
A
S
D
S
L
A
R
M
V
E
R
A
G
A
D
A
V
I
A
E
G
M
E
S
G
G
H
I
G
E
-----------
V
T
T
F
V
L
V
N
K
V
S
R
S
V
N
I
P
V
I
A
A
G
G
I
A
D
G
R
G
M
A
A
A
F
A
L
G
A
E
A
V
Q
M
G
T
R
F
V
A
S
V
E
S
D
V
H
P
V
Y
K
E
K
I
V
K
A
SI
R
D
--
T
V
V
T
G
A
---
H
P
A
R
V
L
R
T
P
F
A
R
K
I
Q
-----------------
E
E
M
L
-
V
G
S
L
R
R
A
V
V
-
E
G
D
L
E
R
G
S
F
A
V
G
Q
S
A
G
L
I
D
E
I
K
P
V
K
Q
I
I
E
D
I
L
K
E
F
K
E
--
64
HHSearch
64.46
32%
-76
- C3 -
-
2Z6I
2
?
A:
[3-308]
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
A
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
F
------------------------------------------
V
E
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
-----------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
RD
I
D
--
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
K
Q
---DL
E
I
F
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
--
61
HHSearch
63.62
30%
-77
- C3 -
-
4IQL
4
?
A:
[22-324]
N
R
I
C
E
L
L
G
I
E
H
P
I
I
S
G
G
M
V
W
C
S
G
W
K
L
A
S
A
V
S
N
C
G
G
L
G
L
I
G
A
G
S
M
H
P
D
N
L
E
H
H
I
R
S
C
K
A
A
T
D
K
P
F
G
V
N
V
P
L
L
Y
P
E
------------------------------------------
M
D
K
I
M
E
I
I
M
R
E
H
V
P
V
V
V
T
S
A
G
S
P
-
K
V
W
T
A
K
L
K
A
A
G
S
K
V
I
H
V
V
S
S
A
T
F
A
R
K
S
E
A
A
G
V
D
A
I
V
A
E
G
F
E
A
G
G
H
N
G
R
E
---------
E
T
T
T
L
C
L
I
P
E
V
V
D
A
V
N
I
P
V
V
A
A
G
G
I
A
S
G
R
A
V
A
A
A
L
A
L
G
A
D
A
V
Q
V
G
T
R
F
A
L
S
E
E
S
S
A
H
E
D
F
K
A
H
C
R
R
S
VE
G
D
--
T
M
L
S
L
K
-
A
V
S
P
T
R
L
L
K
N
K
F
Y
Q
D
V
F
A
A
E
Q
R
---
G
A
S
V
E
E
--
L
R
E
L
L
G
R
G
R
A
K
Q
G
I
F
-
E
G
D
L
H
E
G
E
L
E
I
G
Q
A
V
S
Q
I
S
H
A
E
T
V
A
E
I
M
V
D
L
V
D
G
Y
K
R
--
65
HHSearch
63.30
32%
-78
- C3 -
-
2Z6I
1
?
B:
[3-308]
T
R
I
T
E
L
L
K
I
D
Y
P
I
F
Q
G
G
M
A
W
V
A
D
G
D
L
A
G
A
V
S
K
A
G
G
L
G
I
I
G
G
G
N
A
P
K
E
V
V
K
A
N
I
D
K
I
K
S
L
T
D
K
P
F
G
V
N
I
M
L
L
S
P
F
------------------------------------------
V
E
D
I
V
D
L
V
I
E
E
G
V
K
V
V
T
T
G
A
G
N
P
-
S
K
Y
M
E
R
F
H
E
A
G
I
I
V
I
P
V
V
P
S
V
A
L
A
K
R
M
E
K
I
G
A
D
A
V
I
A
E
G
M
E
A
G
G
H
I
G
K
-----------
L
T
T
M
T
L
V
R
Q
V
A
T
A
I
S
I
P
V
I
A
A
G
G
I
A
D
G
E
G
A
A
A
G
F
M
L
G
A
E
A
V
Q
V
G
T
R
F
V
V
A
K
E
S
N
A
H
P
N
Y
K
E
K
I
L
K
A
RD
I
D
--
T
T
I
S
A
Q
H
F
G
H
A
V
R
A
I
K
N
Q
L
T
R
D
F
E
L
A
E
K
D
A
F
K
Q
E
D
P
DL
E
I
F
E
Q
M
G
-
A
G
A
L
A
K
A
V
V
-
H
G
D
V
D
G
G
S
V
M
A
G
Q
I
A
G
L
V
S
K
E
E
T
A
E
E
I
L
K
D
L
Y
Y
G
A
A
K
--